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https://www.readbyqxmd.com/read/29783000/controlling-nutritional-status-score-a-promising-prognostic-marker-in-patients-with-gastrointestinal-cancers-after-surgery-a-systematic-review-and-meta-analysis
#1
REVIEW
Yi Zhang, Xu Zhang
BACKGROUND: Controlling nutritional status (CONUT) score has been reported to correlate with gastrointestinal (GI) cancer prognosis, but the results remain inconsistent. This study was to synthetically determine the associations between CONUT score and prognosis in GI cancers. METHODS: Online databases PubMed, Web of Science, Cochrane library, Embase, Google scholar, Wanfang and National Knowledge Infrastructure (CNKI) were searched for eligible articles published prior to March 10, 2018...
May 18, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29782526/decreased-risk-of-pneumonia-in-stroke-patients-receiving-acupuncture-a-nationwide-matched-pair-retrospective-cohort-study
#2
Chuen-Chau Chang, Ta-Liang Chen, Chao-Shun Lin, Chi-Li Chung, Chun-Chieh Yeh, Chaur-Jong Hu, Hsin-Long Lane, Chien-Chang Liao, Chun-Chuan Shih
BACKGROUND: Acupuncture treatment is common among stroke patients, but there is limited information available on whether acupuncture effectively prevents post-stroke pneumonia. The aim of this study was to analyze the differential risk of pneumonia after stroke between patients who did and did not receive acupuncture after discharge. METHODS: We used the Taiwan National Health Insurance Research Database to conduct a retrospective cohort study using propensity score matched-pairs of new stroke patients in 2000-2004 who did and did not receive acupuncture post-stroke...
2018: PloS One
https://www.readbyqxmd.com/read/29781326/progression-free-survival-with-endocrine-based-therapies-following-progression-on-non-steroidal-aromatase-inhibitor-among-postmenopausal-women-with-hr-her2-metastatic-breast-cancer-a-network-meta-analysis
#3
Rajeev Ayyagari, Derek Tang, Oscar Patterson-Lomba, Zhou Zhou, Jipan Xie, David Chandiwana, Anand A Dalal, Polly Ann Niravath
OBJECTIVE: To quantify the comparative efficacy of currently available endocrine-based therapies (ETs) for postmenopausal women with HR+/HER2- mBC after NSAI progression. DESIGN: network meta-analysis (NMA) Methods: Randomized clinical trials of ETs for HR+/HER2- mBC were identified via a systematic literature review using Medline, EMBASE, Cochrane Library, and key conference proceedings. All trials met the following inclusion criteria: 1) included women with HR+/HER2- mBC, 2) previous treatment with ETs or chemotherapy as first-line therapy, 3) treatment with ET as monotherapy or in combination with targeted therapy, 4) PFS was reported, and 5) published in 2007 (when HER2 testing became standardized) or later...
May 21, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29780162/dietary-antioxidant-intake-and-the-risk-of-developing-barrett-s-oesophagus-and-oesophageal-adenocarcinoma
#4
James H-E Kang, Robert Luben, Leo Alexandre, Andrew R Hart
BACKGROUND: We investigated in a cohort study, for the first time using 7-day food diaries (7-DFDs), for age-dependent inverse associations with antioxidants, which have anti-carcinogenic properties, and development of Barrett's oesophagus (BO) and oesophageal adenocarcinoma (OAC). METHODS: A total of 24,068 well individuals completed 7-DFDs and donated blood. Vitamins C and E, carotenes, zinc and selenium intakes, and plasma vitamin C were measured. Participants were monitored for 15 years for BO and OAC...
May 21, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29780025/neighbourhood-socioeconomic-position-and-risks-of-major-chronic-diseases-and-all-cause-mortality-a-quasi-experimental-study
#5
Daniel Kim, Richard H Glazier, Brandon Zagorski, Ichiro Kawachi, Philip Oreopoulos
OBJECTIVES: This study estimated the health impacts of neighbourhood socioeconomic position (SEP) among public housing residents. Because applicants to public housing were assigned to housing projects primarily based on factors other than personal choice, we capitalised on a quasirandom source of variation in neighbourhood of residence to obtain more valid estimates of the health impacts of neighbourhood SEP. DESIGN: Quasiexperimental study. SETTING: Greater Metropolitan Toronto area, Canada...
May 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29779216/glutamate-metabolism-in-cerebral-mitochondria-after-ischemia-and-post-ischemic-recovery-during-aging-relationships-with-brain-energy-metabolism
#6
Federica Ferrari, Antonella Gorini, Siegfried Hoyer, Roberto Federico Villa
Glutamate is involved in cerebral ischemic injury, but its role has not been completely clarified and studies are required to understand how minimize its detrimental effects, contemporarily boosting the positive ones. In fact, glutamate is not only a neurotransmitter, but primarily a key metabolite for brain bioenergetics. Thus, we investigated the relationships between glutamate and brain energy metabolism in an in vivo model of complete cerebral ischemia of 15 min and during post-ischemic recovery after 1, 24, 48, 72 and 96 hrs in 1 year- adult and 2 year-old aged rats...
May 20, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29779202/tumour-stage-and-gender-predict-recurrence-and-second-primary-malignancies-in-head-and-neck-cancer-a-multicentre-study-within-the-inhance-consortium
#7
Emanuele Leoncini, Vladimir Vukovic, Gabriella Cadoni, Luca Giraldi, Roberta Pastorino, Dario Arzani, Livia Petrelli, Victor Wünsch-Filho, Tatiana Natasha Toporcov, Raquel Ayub Moyses, Keitaro Matsuo, Cristina Bosetti, Carlo La Vecchia, Diego Serraino, Lorenzo Simonato, Franco Merletti, Paolo Boffetta, Mia Hashibe, Yuan-Chin Amy Lee, Stefania Boccia
Recurrence and second primary cancer (SPC) continue to represent major obstacles to long-term survival in head and neck cancer (HNC). Our aim was to evaluate whether established demographics, lifestyle-related risk factors for HNC and clinical data are associated with recurrence and SPC in HNC. We conducted a multicentre study by using data from five studies members of the International Head and Neck Cancer Epidemiology consortium-Milan, Rome, Western Europe, Sao Paulo, and Japan, totalling 4005 HNC cases with a median age of 59 (interquartile range 52-67)...
May 19, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29779200/impact-of-antithrombotic-regimen-on-mortality-ischemic-and-bleeding-outcomes-after-transcatheter-aortic-valve-replacement
#8
Anubodh Varshney, Ryan A Watson, Andrew Noll, KyungAh Im, Jeffrey Rossi, Pinak Shah, Robert P Giugliano
INTRODUCTION: Optimal antithrombotic therapy after transcatheter aortic valve replacement (TAVR) remains unclear. We evaluated the association between antithrombotic regimens and outcomes in TAVR patients. METHODS: We retrospectively analyzed consecutive patients who underwent TAVR at a single academic center from April 2009 to March 2014. Antithrombotic regimens were classified as single or dual antiplatelet therapy (AP), single antiplatelet plus anticoagulant (SAC), or triple therapy (TT)...
May 19, 2018: Cardiology and Therapy
https://www.readbyqxmd.com/read/29778737/cancer-immunotherapy-efficacy-and-patients-sex-a-systematic-review-and-meta-analysis
#9
Fabio Conforti, Laura Pala, Vincenzo Bagnardi, Tommaso De Pas, Marco Martinetti, Giuseppe Viale, Richard D Gelber, Aron Goldhirsch
BACKGROUND: Despite the acknowledged sex-related dimorphism in immune system response, little is known about the effect of patients' sex on the efficacy of immune checkpoint inhibitors as cancer treatments. We did a systematic review and meta-analysis to assess the heterogeneity of immune checkpoint inhibitor efficacy between men and women. METHODS: We systematically searched PubMed, MEDLINE, Embase, and Scopus, from database inception to Nov 30, 2017, for randomised controlled trials of immune checkpoint inhibitors (inhibitors of PD-1, CTLA-4, or both) that had available hazard ratios (HRs) for death according to patients' sex...
May 16, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29778540/the-clinicopathological-and-prognostic-value-of-long-non-coding-rna-zeb1-as1-in-solid-tumors-a-meta-analysis
#10
REVIEW
Chaojie Liang, Jing Liu, Hua Ge, Yingchen Xu, Guangming Li, Jixiang Wu
BACKGROUND AND AIM: Studies have reported that Zinc finger E-box binding homeobox 1 antisense 1 (ZEB1-AS1) is overexpressed in many malignant tumors. However, the sample size in those studies was limited, so the clinicopathological and prognostic value of ZEB1-AS1 in solid tumors remains undetermined, Accordingly, the aim of this meta-analysis was to evaluate the relationship between the expression of lncRNA ZEB1-AS1 and clinicopathological characteristics and prognosis in patients with solid tumors...
May 17, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29778463/urinary-8-isoprostane-levels-and-occurrence-of-lung-colorectal-prostate-breast-and-overall-cancer-results-from-a-large-population-based-cohort-study-with-14-years-of-follow-up
#11
Xīn Gào, Hermann Brenner, Bernd Holleczek, Katarina Cuk, Yan Zhang, Ankita Anusruti, Yang Xuan, Yiwei Xu, Ben Schöttker
BACKGROUND: Urinary 8-isoprostane is an established biomarker for lipid peroxidation. However, the association between its pre-diagnostic levels and cancer incidence has rarely been evaluated. METHODS: 8,793 older adults from the German ESTHER cohort were followed up for cancer incidence by cancer registry data. A directed acyclic graph was utilized to identify potential confounders. Multivariate Cox regression models were applied to estimate hazard ratios (HRs) and 95% confidence intervals (95% CI)...
May 17, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29777909/lncrnas-as-potential-molecular-biomarkers-for-the-clinicopathology-and-prognosis-of-glioma-a-systematic-review-and-meta-analysis
#12
REVIEW
Qian Zhou, Jing Liu, Jing Quan, Wenlan Liu, Hui Tan, Weiping Li
BACKGROUND: An increasing number of studies have shown that long noncoding RNAs (lncRNAs) play important roles in the development of glioma. However, a systematic review and meta-analysis to evaluate the clinical value of lncRNA expression in glioma patients is lacking. We performed this study to assess the relationship between the expression of various lncRNAs and the clinicopathological features, diagnosis and prognosis of glioma. MATERIALS AND METHODS: Eligible studies were identified through a comprehensive literature search...
May 16, 2018: Gene
https://www.readbyqxmd.com/read/29777264/empagliflozin-reduces-cardiovascular-events-mortality-and-renal-events-in-participants-with-type-2-diabetes-after-coronary-artery-bypass-graft-surgery-subanalysis-of-the-empa-reg-outcome%C3%A2-randomised-trial
#13
Subodh Verma, C David Mazer, David Fitchett, Silvio E Inzucchi, Egon Pfarr, Jyothis T George, Bernard Zinman
AIMS/HYPOTHESIS: After coronary artery bypass graft (CABG) surgery in individuals with type 2 diabetes, there remains a considerable residual cardiovascular risk. In the EMPA-REG OUTCOME® trial in participants with type 2 diabetes and established cardiovascular disease, empagliflozin reduced the risk of cardiovascular death by 38%, all-cause mortality by 32%, hospitalisation for heart failure by 35% and incident or worsening nephropathy by 39% vs placebo when given in addition to standard of care...
May 19, 2018: Diabetologia
https://www.readbyqxmd.com/read/29777049/prospective-study-of-coffee-consumption-and-cancer-incidence-in-non-white-populations
#14
Song-Yi Park, Neal D Freedman, Christopher A Haiman, Loic Le Marchand, Lynne R Wilkens, Veronica Wendy Setiawan
BACKGROUND: Coffee intake has been associated with risk of cancers, but the findings, mostly from studies in white populations, are inconsistent. We examined the association of coffee consumption with overall cancer incidence and specific cancer sites in a prospective study of African Americans, Native Hawaiians, Japanese Americans, Latinos and whites. METHODS: 167,720 participants of the Multiethnic Cohort in Hawaii and Los Angeles were included. Baseline coffee intake was assessed by a validated food-frequency questionnaire...
May 18, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29775617/preoperative-lymphocyte-to-monocyte-ratio-predicts-breast-cancer-outcome-a-meta-analysis
#15
REVIEW
Ru-Jin Hu, Qin Liu, Jian-Ying Ma, Jing Zhou, Gang Liu
AIM: To assess the prognostic value of the preoperative lymphocyte-to-monocyte ratio (LMR) in patients with breast cancer (BC). METHODS: Relevant studies were systematically retrieved from the online Cochrane, MEDLINE, EMBASE and CNKI databases published until February 2018. The end points were overall survival (OS), disease-free survival (DFS), and clinicopathological parameters. Meta-analysis was performed using hazard ratios (HRs) or odds ratios (ORs) and their 95% confidence intervals (CIs) as effect measures...
May 17, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29774403/anti-osteoporosis-drug-use-too-little-too-much-or-just-right-the-hunt-study-norway
#16
M Hoff, S Skurtveit, H E Meyer, A Langhammer, A J Søgaard, U Syversen, E Skovlund, B Abrahamsen, S Forsmo, B Schei
Use of anti-osteoporotic drugs (AODs) was examined in a Norwegian population 50-85 years. Among them with Fracture Risk Assessment Tool (FRAX) score for major osteoporotic fracture ≥ 20, 25% of the women and 17% of the men received AODs. The strongest predictors for AODs were high age in women and use of glucocorticoids among men. INTRODUCTION: To examine the use of anti-osteoporotic drugs (AODs) and to identify predictors for prescriptions. METHODS: Data were obtained from the Nord-Trøndelag Health Study (HUNT3) performed in 2006-2008 and the Norwegian Prescription Database, including 15,075 women and 13,386 men aged 50-85 years...
May 17, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29773991/first-biologic-drug-in-the-treatment-of-ras-wild-type-metastatic-colorectal-cancer-anti-egfr-or-bevacizumab-results-from-a-meta-analysis
#17
REVIEW
Alessandro Ottaiano, Alfonso De Stefano, Monica Capozzi, Anna Nappi, Chiara De Divitiis, Carmela Romano, Lucrezia Silvestro, Antonino Cassata, Rossana Casaretti, Salvatore Tafuto, Michele Caraglia, Massimiliano Berretta, Guglielmo Nasti, Antonio Avallone
Introduction: We performed a meta-analysis in order to analyze and quantify the effect on survival of starting therapy in RAS wild-type (wt) metastatic colorectal cancer (mCRC) patients with anti-EGFR agents or bevacizumab. Patients and Methods: Randomized, phase II or III, clinical trials reporting overall survival (OS) in RAS wt mCRC patients treated with first-line chemotherapy (CT) associated with bevacizumab or anti-EGFR agents were selected. The primary end-point of this meta-analysis was OS; findings were depicted in classical Forest plots...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29773578/relationship-between-glycated-hemoglobin-and-stroke-risk-a-systematic-review-and-meta-analysis
#18
REVIEW
John Peter Mitsios, Elif Ilhan Ekinci, Gregory Peter Mitsios, Leonid Churilov, Vincent Thijs
BACKGROUND: Diabetes mellitus is a major risk factor for ischemic stroke. Rising hemoglobin A1c (HbA1c ) levels are associated with microvascular diabetes mellitus complication development; however, this relationship has not been established for stroke risk, a macrovascular complication. METHODS AND RESULTS: We conducted a systematic review and meta-analysis of observational cohort and nested case-control cohort studies assessing the association between rising HbA1c levels and stroke risk in adults (≥18 years old) with and without type 1 or type 2 diabetes mellitus...
May 17, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29773576/joint-effect-of-carotid-plaque-and-c-reactive-protein-on-first-ever-ischemic-stroke-and-myocardial-infarction
#19
Agnethe Eltoft, Kjell Arne Arntzen, Tom Wilsgaard, John-Bjarne Hansen, Ellisiv B Mathiesen, Stein Harald Johnsen
BACKGROUND: The joint effect of atherosclerosis and CRP (C-reactive protein) on risk of ischemic stroke (IS) and myocardial infarction (MI) has been sparsely studied. The aim of this study was to explore whether CRP mediates the risk of events in subjects with prevalent carotid plaque, examine synergism, and test whether CRP and carotid plaque add to risk prediction beyond traditional risk factors. METHODS AND RESULTS: CRP and carotid total plaque area (TPA) were measured in 10 109 participants in the Tromsø Study from 1994 to 2008...
May 17, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29773120/age-specific-association-between-blood-pressure-and-vascular-and-non-vascular-chronic-diseases-in-0%C3%A2-5-million-adults-in-china-a-prospective-cohort-study
#20
Ben Lacey, Sarah Lewington, Robert Clarke, Xiang Ling Kong, Yiping Chen, Yu Guo, Ling Yang, Derrick Bennett, Fiona Bragg, Zheng Bian, Shaojie Wang, Hua Zhang, Junshi Chen, Robin G Walters, Rory Collins, Richard Peto, Liming Li, Zhengming Chen
BACKGROUND: The age-specific association between blood pressure and vascular disease has been studied mostly in high-income countries, and before the widespread use of brain imaging for diagnosis of the main stroke types (ischaemic stroke and intracerebral haemorrhage). We aimed to investigate this relationship among adults in China. METHODS: 512 891 adults (59% women) aged 30-79 years were recruited into a prospective study from ten areas of China between June 25, 2004, and July 15, 2008...
June 2018: Lancet Global Health
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