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https://www.readbyqxmd.com/read/28089185/joint-replacement-volume-positively-correlates-with-improved-hospital-performance-on-centers-for-medicare-and-medicaid-services-quality-metrics
#1
Rachel A Sibley, Vanessa Charubhumi, Lorraine H Hutzler, Albit R Paoli, Joseph A Bosco
BACKGROUND: The Center for Medicare and Medicaid Services (CMS) is transitioning Medicare from a fee-for-service program into a value-based pay-for-performance program. In order to accomplish this goal, CMS initiated 3 programs that attempt to define quality and seek to reward high-performing hospitals and penalize poor-performing hospitals. These programs include (1) penalties for hospital-acquired conditions (HACs), (2) penalties for excess readmissions for certain conditions, and (3) performance on value-based purchasing (VBP)...
December 21, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28088189/mars-improving-multiple-circular-sequence-alignment-using-refined-sequences
#2
Lorraine A K Ayad, Solon P Pissis
BACKGROUND: A fundamental assumption of all widely-used multiple sequence alignment techniques is that the left- and right-most positions of the input sequences are relevant to the alignment. However, the position where a sequence starts or ends can be totally arbitrary due to a number of reasons: arbitrariness in the linearisation (sequencing) of a circular molecular structure; or inconsistencies introduced into sequence databases due to different linearisation standards. These scenarios are relevant, for instance, in the process of multiple sequence alignment of mitochondrial DNA, viroid, viral or other genomes, which have a circular molecular structure...
January 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28080092/brief-online-interventions-targeting-risk-and-protective-factors-for-increased-and-problematic-alcohol-use-among-american-college-students-studying-abroad
#3
Eric R Pedersen, Clayton Neighbors, David C Atkins, Christine M Lee, Mary E Larimer
Research documents increased and problematic alcohol use during study abroad experiences for college students yet no research documents effective preventive programs with these students. The present randomized controlled trial was designed to prevent increased and problematic alcohol use abroad by correcting misperceptions of peer drinking norms abroad and by promoting positive and healthy adjustment into the host culture (i.e., sojourner adjustment) through brief online personalized feedback interventions...
January 12, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/28080076/adverse-childhood-experiences-and-risk-for-suicidal-behavior-in-male-iraq-and-afghanistan-veterans-seeking-ptsd-treatment
#4
Timothy D Carroll, Joseph M Currier, Wesley H McCormick, Kent D Drescher
OBJECTIVE: Adverse childhood experiences (ACEs) are associated with increased risk for suicide and appear to occur in disproportionately high rates among men who served in the U.S. military. However, research has yet to examine a comprehensive range of ACEs among Iraq/Afghanistan veterans with combat-related posttraumatic stress disorder (PTSD) or whether these premilitary stressors may contribute to suicidal behavior in this highly vulnerable population. METHOD: A sample of 217 men entering a residential program for combat-related PTSD completed measures for ACEs, combat exposure, and lifetime suicidal ideation and attempts...
January 12, 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/28077053/patient-empowerment-a-systematic-review-of-questionnaires-measuring-empowerment-in-cancer-patients
#5
Nanna Bjerg Eskildsen, Clara Ruebner Joergensen, Thora Grothe Thomsen, Lone Ross, Susanne Malchau Dietz, Mogens Groenvold, Anna Thit Johnsen
BACKGROUND: There is an increased attention to and demand for patient empowerment in cancer treatment and follow-up programs. Patient empowerment has been defined as feeling in control of or having mastery in relation to cancer and cancer care. This calls for properly developed questionnaires assessing empowerment from the user perspective. The aim of this review was to identify questionnaires and subscales measuring empowerment and manifestations of empowerment among cancer patients...
January 12, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28075655/experiences-and-preferences-for-end-of-life-care-for-young-adults-with-cancer-and-their-informal-carers-a-narrative-synthesis
#6
Nothando Ngwenya, Charlotte Kenten, Louise Jones, Faith Gibson, Susie Pearce, Mary Flatley, Rachael Hough, L Caroline Stirling, Rachel M Taylor, Geoff Wong, Jeremy Whelan
To review the qualitative literature on experiences of and preferences for end-of-life care of people with cancer aged 16-40 years (young adults) and their informal carers. A systematic review using narrative synthesis of qualitative studies using the 2006 UK Economic and Social Research Council research methods program guidance. Seven electronic bibliographic databases, two clinical trials databases, and three relevant theses databases were searched from January 2004 to October 2015. Eighteen articles were included from twelve countries...
January 11, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28074288/clinical-research-participation-among-adolescent-and-young-adults-at-an-nci-designated-comprehensive-cancer-center-and-affiliated-pediatric-hospital
#7
Stacy D Sanford, Jennifer L Beaumont, Mallory A Snyder, Jennifer Reichek, John M Salsman
PURPOSE: Minimal clinical trial participation among adolescents and young adults (AYAs) with cancer limits scientific progress and ultimately their clinical care and outcomes. These analyses examine the current state of AYA clinical research participation at a Midwestern comprehensive cancer center and affiliated pediatric hospital to advise program development and increase availability of trials and AYA participation. Enrollment is examined across all diagnoses, the entire AYA age spectrum (15-39), and both cancer therapeutic and supportive care protocols...
January 10, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28073797/physical-and-cultural-determinants-of-postpartum-pelvic-floor-support-and-symptoms-following-vaginal-delivery-a-protocol-for-a-mixed-methods-prospective-cohort-study
#8
Ingrid E Nygaard, Erin Clark, Lauren Clark, Marlene J Egger, Robert Hitchcock, Yvonne Hsu, Peggy Norton, Ana Sanchez-Birkhead, Janet Shaw, Xiaoming Sheng, Michael Varner
INTRODUCTION: Pelvic floor disorders (PFDs), including pelvic organ prolapse (POP), stress and urgency urinary incontinence, and faecal incontinence, are common and arise from loss of pelvic support. Although severe disease often does not occur until women become older, pregnancy and childbirth are major risk factors for PFDs, especially POP. We understand little about modifiable factors that impact pelvic floor function recovery after vaginal birth. This National Institutes of Health (NIH)-funded Program Project, 'Bridging physical and cultural determinants of postpartum pelvic floor support and symptoms following vaginal delivery', uses mixed-methods research to study the influences of intra-abdominal pressure, physical activity, body habitus and muscle fitness on pelvic floor support and symptoms as well as the cultural context in which women experience those changes...
January 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28068515/comparative-analysis-of-amino-acid-composition-in-the-active-site-of-nirk-gene-encoding-copper-containing-nitrite-reductase-cunir-in-bacterial-spp
#9
Utpal Kumar Adhikari, M Mizanur Rahman
The nirk gene encoding the copper-containing nitrite reductase (CuNiR), a key catalytic enzyme in the environmental denitrification process that helps to produce nitric oxide from nitrite. The molecular mechanism of denitrification process is definitely complex and in this case a theoretical investigation has been conducted to know the sequence information and amino acid composition of the active site of CuNiR enzyme using various Bioinformatics tools. 10 Fasta formatted sequences were retrieved from the NCBI database and the domain and disordered regions identification and phylogenetic analyses were done on these sequences...
December 31, 2016: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28068167/vehicle-exposure-and-spinal-musculature-fatigue-in-military-warfighters-a-meta-analysis
#10
Roger O Kollock, Kenneth E Games, Alan E Wilson, JoEllen M Sefton
CONTEXT:  Spinal musculature fatigue from vehicle exposure may place warfighters at risk for spinal injuries and pain. Research on the relationship between vehicle exposure and spinal musculature fatigue is conflicting. A better understanding of the effect of military duty on musculoskeletal function is needed before sports medicine teams can develop injury-prevention programs. OBJECTIVE:  To determine if the literature supports a definite effect of vehicle exposure on spinal musculature fatigue...
November 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/28066599/clinicopathological-and-prognostic-significance-of-programmed-cell-death-ligand-1-pd-l1-expression-in-patients-with-esophageal-squamous-cell-carcinoma-a-meta-analysis
#11
Hai-Xia Qu, Li-Ping Zhao, Shu-Hui Zhan, Chang-Xin Geng, Lin Xu, Yong-Ning Xin, Xiang-Jun Jiang
BACKGROUND: The clinicopathological and prognostic significance of programmed cell death ligand 1 (PD-L1) expression in patients with esophageal squamous cell carcinoma (ESCC) remains controversial. To investigate this question, we conducted a meta-analysis. METHODS: A comprehensive literature search of electronic databases (up to July 10, 2016) was performed for relevant studies using multiple search strategies. Correlation between PD-L1 expression and clinicopathological features/overall survival (OS) was analyzed...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28064385/review-of-yoga-therapy-during-cancer-treatment
#12
REVIEW
Suzanne C Danhauer, Elizabeth L Addington, Stephanie J Sohl, Alejandro Chaoul, Lorenzo Cohen
PURPOSE: Reviews of yoga research that distinguish results of trials conducted during (versus after) cancer treatment are needed to guide future research and clinical practice. We therefore conducted a review of non-randomized studies and randomized controlled trials of yoga interventions for children and adults undergoing treatment for any cancer type. METHODS: Studies were identified via research databases and reference lists. Inclusion criteria were the following: (1) children or adults undergoing cancer treatment, (2) intervention stated as yoga or component of yoga, and (3) publication in English in peer-reviewed journals through October 2015...
January 7, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28062517/firebrowser-an-r-client-to-the-broad-institute-s-firehose-pipeline
#13
Mario Deng, Johannes Brägelmann, Ivan Kryukov, Nuno Saraiva-Agostinho, Sven Perner
With its Firebrowse service (http://firebrowse.org/) the Broad Institute is making large-scale multi-platform omics data analysis results publicly available through a Representational State Transfer (REST) Application Programmable Interface (API). Querying this database through an API client from an arbitrary programming environment is an essential task, allowing other developers and researchers to focus on their analysis and avoid data wrangling. Hence, as a first result, we developed a workflow to automatically generate, test and deploy such clients for rapid response to API changes...
2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/28061750/genomecat-a-versatile-tool-for-the-analysis-and-integrative-visualization-of-dna-copy-number-variants
#14
Katrin Tebel, Vivien Boldt, Anne Steininger, Matthias Port, Grit Ebert, Reinhard Ullmann
BACKGROUND: The analysis of DNA copy number variants (CNV) has increasing impact in the field of genetic diagnostics and research. However, the interpretation of CNV data derived from high resolution array CGH or NGS platforms is complicated by the considerable variability of the human genome. Therefore, tools for multidimensional data analysis and comparison of patient cohorts are needed to assist in the discrimination of clinically relevant CNVs from others. RESULTS: We developed GenomeCAT, a standalone Java application for the analysis and integrative visualization of CNVs...
January 6, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28057335/big-data-science-a-literature-review-of-nursing-research-exemplars
#15
Bonnie L Westra, Martha Sylvia, Elizabeth F Weinfurter, Lisiane Pruinelli, Jung In Park, Dianna Dodd, Gail M Keenan, Patricia Senk, Rachel L Richesson, Vicki Baukner, Christopher Cruz, Grace Gao, Luann Whittenburg, Connie W Delaney
BACKGROUND: Big data and cutting-edge analytic methods in nursing research challenge nurse scientists to extend the data sources and analytic methods used for discovering and translating knowledge. PURPOSE: The purpose of this study was to identify, analyze, and synthesize exemplars of big data nursing research applied to practice and disseminated in key nursing informatics, general biomedical informatics, and nursing research journals. METHODS: A literature review of studies published between 2009 and 2015...
December 8, 2016: Nursing Outlook
https://www.readbyqxmd.com/read/28057171/predicting-high-impact-pharmacological-targets-by-integrating-transcriptome-and-text-mining-features
#16
Anatoly Mayburd, Ancha Baranova
PURPOSE: Novel, "outside of the box" approaches are needed for evaluating candidate molecules, especially in oncology. Throughout the years of 2000-2010, the efficiency of drug development fell to barely acceptable levels, and in the second decade of this century, levels have improved only marginally. This dismal condition continues despite unprecedented progress in the development of a variety of high-throughput tools, computational methods, aggregated databases, drug repurposing programs and innovative chemistries...
October 2016: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28054326/what-is-the-timing-of-general-health-adverse-events-that-occur-after-total-joint-arthroplasty
#17
Daniel D Bohl, Nathaniel T Ondeck, Bryce A Basques, Brett R Levine, Jonathan N Grauer
BACKGROUND: Despite extensive research regarding risk factors for adverse events after total joint arthroplasty (TJA), there are few publications describing the timing at which such adverse events occur. QUESTIONS/PURPOSES: (1) On which postoperative day do certain adverse events occur? (2) What adverse events occur earlier after TKA than after THA? (3) For each adverse event, what proportion occurred after hospital discharge? METHODS: We screened the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) to identify all patients undergoing primary THA and primary TKA between 2005 and 2013, resulting in a study population of 124,657 patients evaluated as part of this retrospective database analysis...
January 4, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28052133/pulmonary-hypertension-scientometric-analysis-and-density-equalizing-mapping
#18
Michael Götting, Mario Schwarzer, Alexander Gerber, Doris Klingelhöfer, David A Groneberg
Pulmonary hypertension (PH) is characterized by the increase of the mean pulmonary arterial pressure in the lung circulation. Despite the large number of experimental and clinical studies conducted on pulmonary hypertension, there is no comprehensive work that analyzed the global research activity on PH so far. We retrieved the bibliometric data of the publications on pulmonary hypertension for two periods from the Web of science database. Here, we set the first investigation period from 1900 to 2007 (t1) due to the cited half life of articles and the relating difficulties to interpret the citation parameters...
2017: PloS One
https://www.readbyqxmd.com/read/28048659/tu-fg-201-03-automatic-pre-delivery-verification-using-statistical-analysis-of-consistencies-in-treatment-plan-parameters-by-the-treatment-site-and-modality
#19
S Liu, Y Wu, X Chang, H Li, D Yang
PURPOSE: A novel computer software system, namely APDV (Automatic Pre-Delivery Verification), has been developed for verifying patient treatment plan parameters right prior to treatment deliveries in order to automatically detect and prevent catastrophic errors. METHODS: APDV is designed to continuously monitor new DICOM plan files on the TMS computer at the treatment console. When new plans to be delivered are detected, APDV checks the consistencies of plan parameters and high-level plan statistics using underlying rules and statistical properties based on given treatment site, technique and modality...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048641/tu-fg-207b-01-report-on-development-of-a-database-of-nih-funding-of-medical-physicists
#20
B Whelan
: Up-to-date knowledge about federal funding opportunities related to medical physics research, as well as obtaining skills for writing effective grant proposals are critical for academic and entrepreneurial medical physicists. In this symposium, program directors from key federal research funding agencies, including the National Cancer Institute, the National Institute of Biomedical Imaging and Bioengineering, and the National Science Foundation, will present information about current funding opportunities relevant to the field of medical physics...
June 2016: Medical Physics
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