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https://www.readbyqxmd.com/read/28645207/development-and-validation-of-an-electronic-medical-record-emr-based-computed-phenotype-of-hiv-1-infection
#1
Devon W Paul, Nigel B Neely, Meredith Clement, Isaretta Riley, Mashael Al-Hegelan, Matthew Phelan, Monica Kraft, David M Murdoch, Joseph Lucas, John Bartlett, Mehri McKellar, Loretta G Que
Background: Electronic medical record (EMR) computed algorithms allow investigators to screen thousands of patient records to identify specific disease cases. No computed algorithms have been developed to detect all cases of human immunodeficiency virus (HIV) infection using administrative, laboratory, and clinical documentation data outside of the Veterans Health Administration. We developed novel EMR-based algorithms for HIV detection and validated them in a cohort of subjects in the Duke University Health System (DUHS)...
June 22, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28645142/polyphyly-of-arundinoideae-poaceae-and-evolution-of-the-twisted-geniculate-lemma-awn
#2
J K Teisher, M R McKain, B A Schaal, E A Kellogg
Background and Aims: Subfamily Arundinoideae represents one of the last unsolved taxonomic mysteries in the grass family (Poaceae) due to the narrow and remote distributions of many of its 19 morphologically and ecologically heterogeneous genera. Resolving the phylogenetic relationships of these genera could have substantial implications for understanding character evolution in the grasses, for example the twisted geniculate awn - a hygroscopic awn that has been shown to be important in seed germination for some grass species...
June 21, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28645101/co-localization-of-endogenous-arf6-and-its-activator-efa6d-in-the-granular-convoluted-tubule-cells-of-mouse-submandibular-glands-under-normal-conditions-and-when-stimulated-by-isoproterenol-noradrenaline-and-carbachol
#3
Apussara Tachow, Wipawee Thoungseabyoun, Laorrat Phuapittayalert, Kanoktip Petcharat, Hiroyuki Sakagami, Hisatake Kondo, Wiphawi Hipkaeo
OBJECTIVE: This study proposed to investigate the localization at light and electron microscopic levels of Arf6 and its activator EFA6D in the mouse submandibular gland (SMG) under normal conditions and when stimulated by adrenergic or cholinergic agonists. MATERIALS AND METHODS: SMGs of male adult mice were utilized for immunoblotting and immuno-light and -electron microscopic analyses. Isoproterenol and noradrenalin were used as adrenergics, while carbachol was used for the cholinergic stimulant...
June 13, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28645068/fracture-roughness-and-phase-transformation-in-cad-cam-milling-and-subsequent-surface-treatments-of-lithium-metasilicate-disilicate-glass-ceramics
#4
Abdur-Rasheed Alao, Richard Stoll, Xiao-Fei Song, John R Abbott, Yu Zhang, Jaafar Abduo, Ling Yin
This paper studied surface fracture, roughness and morphology, phase transformations, and material removal mechanisms of lithium metasilicate/disilicate glass ceramics (LMGC/LDGC) in CAD/CAM-milling and subsequent surface treatments. LMGC (IPS e.max CAD) blocks were milled using a chairside dental CAD/CAM milling unit and then treated in sintering, polishing and glazing processes. X-ray diffraction was performed on all processed surfaces. Scanning electron microscopy (SEM) was applied to analyse surface fracture and morphology...
June 15, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28645057/effects-of-salinity-and-short-term-elevated-atmospheric-co2-on-the-chemical-equilibrium-between-co2-fixation-and-photosynthetic-electron-transport-of-stevia-rebaudiana-bertoni
#5
Sayed Hussin, Nicole Geissler, Mervat M M El-Far, Hans-Werner Koyro
The effect of water salinity on plant growth and photosynthetic traits of Stevia rebaudiana was investigated to determine its level and mechanisms of salinity tolerance. It was also attempted to assess how short-term elevated CO2 concentration would influence the boundaries and mechanisms of its photosynthetic capacity. The plants were grown in gravel/hydroponic system under controlled greenhouse conditions and irrigated with four different salinity levels (0, 25, 50 and 100 mol m(-3)NaCl). Low salinity did not significantly alter the plant fresh weight, which was substantially decreased by 67% at high salinity treatment...
June 15, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28645037/slip-additive-migration-surface-morphology-and-performance-on-injection-moulded-high-density-polyethylene-closures
#6
Nabeen Dulal, Robert Shanks, Thomas Gengenbach, Harsharn Gill, David Chalmers, Benu Adhikari, Isaac Pardo Martinez
HYPOTHESIS: The amount and distribution of slip agents, erucamide, and behenamide, on the surface of high-density polyethene, is determined by integral characteristics of slip agent structure and polymer morphology. A suite of surface analysis techniques was applied to correlate physicochemical properties with slip-additive migration behaviour and their surface morphology. The migration, surface morphology and physicochemical properties of the slip additives, crystallinity and orientation of polyethene spherulites and interaction between slip additives and high-density polyethene influence the surface characteristics...
June 13, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28645036/influence-of-surface-states-on-blinking-characteristics-of-single-colloidal-cdse-cds-zns-core-multishell-quantum-dot
#7
Hao Xu, Hjalmar Brismar, Ying Fu
We carefully characterized the fluorescence blinking of single colloidal CdSe-CdS/ZnS core-multishell quantum dots (QDs) with different surface modifications, including octadecylamine (ODA) coated QDs dispersed in chloroform, aqueous 3-mercaptopropionic acids (3MPA) coated QDs in HEPES solution treated by Ca(2+) ions and ethylene glycol tetraacetic acid (EGTA, Ca(2+) chelator), and aqueous 3MPA-QDs treated by glycerol. It was found that the on- and off-state probability density distributions displayed different rules...
June 16, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28644912/biofilm-formation-and-disinfectant-resistance-of-salmonella-spp-in-mono-and-dual-species-with-pseudomonas-aeruginosa
#8
Xinyi Pang, Yishan Yang, Hyun-Gyun Yuk
AIMS: This study aimed to evaluate the biofilm formation and disinfectant resistance of Salmonella cells in mono- and dual-species biofilms with Pseudomonas aeruginosa, and to investigate the role of extracellular polymeric substances (EPS) in protection of biofilms against disinfection treatment. METHODS AND RESULTS: The populations of Salmonella in mono- or dual-species biofilms with P. aeruginosa on stainless steel (SS) coupons were determined before and after exposure to commercial disinfectant, 50 μg ml(-1) chlorine or 200 μg ml(-1) Ecolab(®) Whisper(™) V (a blend of four effective quaternary ammonium compounds)...
June 23, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28644837/real-world-first-line-treatment-and-overall-survival-in-non-small-cell-lung-cancer-without-known-egfr-mutations-or-alk-rearrangements-in-us-community-oncology-setting
#9
Amy P Abernethy, Ashwini Arunachalam, Thomas Burke, Caroline McKay, Xiting Cao, Rachael Sorg, David P Carbone
PURPOSE: To establish a baseline for care and overall survival (OS) based upon contemporary first-line treatments prescribed in the era before the introduction of immune checkpoint inhibitors, for people with metastatic non-small cell lung cancer (NSCLC) without common actionable mutations. METHODS: Using a nationally representative electronic health record data from the Flatiron dataset which included 162 practices from different regions in US, we identified patients (≥18 years old) newly diagnosed with stage IV NSCLC initiating first-line anticancer therapy (November 2012- January 2015, with follow-up through July 2015)...
2017: PloS One
https://www.readbyqxmd.com/read/28644811/applying-pattern-recognition-to-high-resolution-images-to-determine-cellular-signaling-status
#10
Michael F Lohrer, Darrin M Hanna, Yang Liu, Kang-Hsin Wang, Fu-Tong Liu, Ted A Laurence, Gang-Yu Liu
Two frequently used tools to acquire high-resolution images of cells are scanning electron microscopy (SEM) and atomic force microscopy (AFM). The former provides a nanometer resolution view of cellular features rapidly and with high throughput, while the latter enables visualizing hydrated and living cells. In current practice, these images are viewed by eye to determine cellular status, e.g. activated versus resting. Automatic and quantitative data analysis is lacking. This work develops an algorithm of pattern recognition that works very effectively for AFM and SEM images...
June 21, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28644800/online-combination-of-epid-cherenkov-imaging-for-3d-dosimetry-in-a-liquid-phantom
#11
Petr Bruza, Jacqueline M Andreozzi, David J Gladstone, Lesley A Jarvis, Joerg Rottmann, Brian W Pogue
Online acquisition of Cherenkov and portal imaging data was combined with a reconstruction scheme called EC3D, providing a full 3D dosimetry of megavoltage X-ray beams in a water tank. The methodology was demonstrated and quantified in a single static beam. Furthermore, the dynamics and visualization of the 3D dose reconstruction were demonstrated with a volumetric modulated arc therapy (VMAT) plan for TG-119 C-Shape geometry. The developed algorithm combines depth dose information, provided by Cherenkov images, with the lateral dose distribution, provided by the electronic portal imaging device (EPID)...
June 20, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28644743/sarcocystis-jamaicensis-n-sp-from-red-tailed-hawks-buteo-jamaicensis-definitive-host-and-ifn-%C3%AE-gene-knockout-mice-as-experimental-intermediate-host
#12
Shiv Verma, Alexa Rosypal Von Dohlen, J Mowery, D Scott, B Rosenthal, J P Dubey, David Lindsay
Here, we report a new species of Sarcocystis with red-tailed hawk (RTH) as the natural definitive host and IFN-γ gene knockout (KO) mice as an experimental intermediate host in which sarcocysts form in muscle. Two RTHs submitted to the Carolina Raptor Center, Huntersville, North Carolina, were euthanized because they could not be rehabilitated and released. Fully sporulated 12.5 x 9.9 m sized sporocysts were found in intestinal scrapings of both hawks. Sporocysts were orally fed to laboratory-reared outbred Swiss Webster mice (SW) (Mus musculus) and also to KO mice...
June 23, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28644742/new-legal-requirements-for-submission-of-product-information-to-poisons-centres-in-eu-member-states
#13
Ronald de Groot, Pieter Brekelmans, Herbert Desel, Irma de Vries
In the past eight years, the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) has been intensively involved in a European Commission led process to develop EU legislation on the information of hazardous products that companies have to notify to EU Poisons Centres (or equivalent "appointed bodies"). As a result of this process, the Commission adopted Regulation (EU) No 2017/542, amending the CLP Regulation by adding an Annex on harmonised product submission requirements. Harmonised mixture information requirements: Detailed and consistent information on the composition of the hazardous product will become available to EU Poisons Centres (PC)...
June 23, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28644706/advance-care-planning-and-palliative-care-integration-for-patients-undergoing-hematopoietic-stem-cell-transplantation
#14
Winnie S Wang, Joseph D Ma, Sandahl H Nelson, Carolyn Revta, Gary T Buckholz, Carolyn M Mulroney, Eric J Roeland
PURPOSE: Advance care planning (ACP) in hematopoietic stem-cell transplantation (HSCT) is challenging, given the potential for cure despite increased morbidity and mortality risk.The aim of this study was to evaluate ACP and palliative care (PC) integration for patients who underwent HSCT. METHODS: A retrospective analysis was conducted and data were extracted from electronic medical records of patients who underwent HSCT between January 2011 and December 2015. Patients who received more than one transplant and who were younger than 18 years of age were excluded...
June 23, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28644701/comparison-between-briganti-partin-and-mskcc-tools-in-predicting-positive-lymph-nodes-in-prostate-cancer-a-systematic-review-and-meta-analysis
#15
Sebastiano Cimino, Giulio Reale, Tommaso Castelli, Vincenzo Favilla, Raimondo Giardina, Giorgio Ivan Russo, Salvatore Privitera, Giuseppe Morgia
OBJECTIVE: The aim of this study was to analyze the discriminative capabilities of Briganti, Partin and Memorial Sloan Kettering Cancer Center (MSKCC) nomograms in predicting lymph-node invasion (LNI) and to perform a meta-analysis to yield pooled area under the receiver operating characteristics curves (AUCs) for model comparison. MATERIALS AND METHODS: An electronic search of the MEDLINE and Embase databases up to October 2016 was undertaken. The AUC value, total number of patients and rate of LNI were extracted from the included references...
June 23, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28644682/management-of-severe-bupropion-poisoning-with-intravenous-lipid-emulsion
#16
Neeraj Chhabra, Carol DesLauriers, Michael Wahl, Sean M Bryant
BACKGROUND: Bupropion toxicity is characterized by central nervous system and cardiovascular toxicity. Intravenous lipid emulsion (ILE) has been suggested as a treatment by some for the treatment of refractory bupropion toxicity. This recommendation is based largely on published case reports and cases presented at scientific meetings. The objective of this study is to characterize the outcomes of patients with suspected bupropion toxicity in which ILE was administered and the indications for its use...
June 23, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28644667/nuclear-resonant-surface-diffraction-of-synchrotron-radiation
#17
Kai Schlage, Liudmila Dzemiantsova, Lars Bocklage, Hans-Christian Wille, Matthias Pues, Guido Meier, Ralf Röhlsberger
Nuclear resonant x-ray diffraction in grazing incidence geometry is used to determine the lateral magnetic configuration in a one-dimensional lattice of ferromagnetic nanostripes. During magnetic reversal, strong nuclear superstructure diffraction peaks appear in addition to the electronic ones due to an antiferromagnetic order in the nanostripe lattice. We show that the analysis of the angular distribution together with the time dependence of the resonantly diffracted x rays reveals surface spin structures with very high sensitivity...
June 9, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28644665/giant-paramagnetism-induced-valley-polarization-of-electrons-in-charge-tunable-monolayer-mose_-2
#18
Patrick Back, Meinrad Sidler, Ovidiu Cotlet, Ajit Srivastava, Naotomo Takemura, Martin Kroner, Atac Imamoğlu
For applications exploiting the valley pseudospin degree of freedom in transition metal dichalcogenide monolayers, efficient preparation of electrons or holes in a single valley is essential. Here, we show that a magnetic field of 7 T leads to a near-complete valley polarization of electrons in a MoSe_{2} monolayer with a density 1.6×10^{12}  cm^{-2}; in the absence of exchange interactions favoring single-valley occupancy, a similar degree of valley polarization would have required a pseudospin g factor of 38...
June 9, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28644662/novel-metal-insulator-transition-at-the-smtio_-3-srtio_-3-interface
#19
Kaveh Ahadi, Susanne Stemmer
We report on a metal-insulator transition (MIT) that is observed in an electron system at the SmTiO_{3}/SrTiO_{3} interface. This MIT is characterized by an abrupt transition at a critical temperature, below which the resistance changes by more than an order of magnitude. The temperature of the transition systematically depends on the carrier density, which is tuned from ∼1×10^{14} to 3×10^{14}  cm^{-2} by changing the SmTiO_{3} thickness. An analysis of the transport properties shows non-Fermi-liquid behavior and mass enhancement as the carrier density is lowered...
June 9, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28644655/formation-of-vacancies-in-si-and-ge-based-clathrates-role-of-electron-localization-and-symmetry-breaking
#20
Amrita Bhattacharya, Christian Carbogno, Bodo Böhme, Michael Baitinger, Yuri Grin, Matthias Scheffler
The formation of framework vacancies in Si- and Ge-based type-I clathrates is studied using density-functional theory as a function of filling the cages with K and Ba atoms. Our analysis reveals the relevance of structural disorder, geometric relaxation, and electronic saturation as well as vibrational and configurational entropy. In the Si clathrates, we find that vacancies are unstable, but very differently, in Ge clathrates, up to three vacancies per unit cell can be stabilized. This contrasting behavior is largely driven by the different energy gain on populating the electronic vacancy states, which originates from the different degree of localization of the valence orbitals of Si and Ge...
June 9, 2017: Physical Review Letters
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