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https://www.readbyqxmd.com/read/28346964/lipoprotein-a-as-a-risk-factor-for-venous-thromboembolism-a-systematic-review-and-meta-analysis-of-the-literature
#1
Francesco Dentali, Vera Gessi, Rossella Marcucci, Monica Gianni, Anna Maria Grandi, Massimo Franchini
Elevated plasma levels of lipoprotein(a) (Lp(a)) are associated with increased cardiovascular risk in several clinical studies. However, there is a lack of data supporting a positive association between elevated Lp(a) levels and venous thromboembolism (VTE). Thus, we conducted a systematic review of the literature to better clarify its role as a risk factor for VTE. Medline and the Embase (up to May 2015) electronic databases were used to identify potentially eligible studies. Studies measuring Lp(a) values in adult patients with deep vein thrombosis and/or pulmonary embolism and in a population of patients without a VTE were selected...
March 27, 2017: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/28346946/association-between-a-virtual-glucose-management-service-and-glycemic-control-in-hospitalized-adult-patients-an-observational-study
#2
Robert J Rushakoff, Mary M Sullivan, Heidemarie Windham MacMaster, Arti D Shah, Alvin Rajkomar, David V Glidden, Michael A Kohn
Background: Inpatient hyperglycemia is common and is linked to adverse patient outcomes. New methods to improve glycemic control are needed. Objective: To determine whether a virtual glucose management service (vGMS) is associated with improved inpatient glycemic control. Design: Cross-sectional analyses of three 12-month periods (pre-vGMS, transition, and vGMS) between 1 June 2012 and 31 May 2015. Setting: 3 University of California, San Francisco, hospitals...
March 28, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28346937/in-crystal-reaction-cycle-of-a-toluene-bound-diiron-hydroxylase
#3
Justin F Acheson, Lucas J Bailey, Thomas C Brunold, Brian G Fox
Electrophilic aromatic substitution is one of the most important and recognizable classes of organic chemical transformation. Enzymes create the strong electrophiles that are needed for these highly energetic reactions by using O2, electrons, and metals or other cofactors. Although the nature of the oxidants that carry out electrophilic aromatic substitution has been deduced from many approaches, it has been difficult to determine their structures. Here we show the structure of a diiron hydroxylase intermediate formed during a reaction with toluene...
March 27, 2017: Nature
https://www.readbyqxmd.com/read/28346903/the-oceanus-statue-of-the-fontana-di-trevi-rome-the-analysis-of-black-crust-as-a-tool-to-investigate-the-urban-air-pollution-and-its-impact-on-the-stone-degradation
#4
Mauro F La Russa, Paola Fermo, Valeria Comite, Cristina M Belfiore, Donatella Barca, Annamaria Cerioni, Marina De Santis, Lorena Francesca Barbagallo, Michela Ricca, Silvestro A Ruffolo
This paper deals with the analysis of black crust coming from the statue of Oceanus belonging to the Fontana di Trevi (Rome). This monument is undoubtedly one of the main touristic attractions of Rome. During the restoration held between 2014 and 2015, some diagnostic analyses had been carried out. It has been highlighted that the sheltered surfaces suffer the formation of black crust, especially on the marble statues. The possibility to sample those degradation products, together with the unaltered substrate, represented an excellent opportunity to characterize the marble itself, to assess the impact of the urban air pollution on the stone material, and to detect the pollutant on a precise timescale...
March 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28346862/communication-about-dying-death-and-bereavement-a-systematic-review-of-children-s-literature
#5
Marina N F Arruda-Colli, Meaghann S Weaver, Lori Wiener
BACKGROUND: Children's books have the potential to facilitate communication about death for children living with a serious illness and for children coping with the death of a loved one. OBJECTIVES: This study examines the content of children's literature relevant to the topic of dying and death and identifies books providers can share with children and their families. DESIGN: A search of children's literature was conducted using four electronic databases and one additional search engine using the word "Death" or "Dying...
March 27, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28346851/aquatic-therapy-for-people-with-lymphedema-a-systematic-review-and-meta-analysis
#6
Wai Yeung, Adam I Semciw
BACKGROUND: Aquatic therapy has several proposed benefits for people with lymphedema. A systematic review of the evidence for aquatic therapy in lymphedema management has not been conducted. METHOD AND RESULTS: Systematic review and meta-analysis were conducted. Five electronic databases were searched to identify randomized controlled trials (RCTs) of people with lymphedema, which compared aquatic therapy with other lymphedema interventions. Qualitative analysis was undertaken where quantitative analysis was not possible...
March 27, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28346840/fabrication-and-evaluation-of-phytomenadione-as-a-nanostructure-lipid-carrier-for-enhancement-of-bioavailability
#7
Bader Mubarak Aljaeid, Khaled Mohamed Hosny
Owing to its limited aqueous solubility, Phytomenadione (vitamin K) undergoes a low bioavailability (50%) with a large inter-individual variability after oral administration. Therefore, the aim of this work was to incorporate vitamine K into nanostructure lipid carrier systems to improve its aqueous solubility and bioavailability. Phytomenadione was used as a liquid lipid, Precirol ATO5, and Compritol ATO were used as solid lipids, Labrasol and Cremophore EL as water soluble surfactants, Capryol 90 and Lauroglycol as lipid soluble surfactants...
March 27, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28346773/noninterventional-naturalistic-retrospective-study-to-describe-prescription-patterns-of-long-acting-injectable-antipsychotics-and-the-impact-of-introducing-a-new-atypical-antipsychotic-in-the-spanish-province-of-tarragona-catchment-area
#8
Ana M Gaviria, José Franco, Guillem Rico, Gerard Muntané, Cristina Sáez, Vanessa Sánchez-Gistau, Joan de Pablo, Elisabet Vilella
Background: We studied the patterns and predictors of long-acting injectable (LAI) antipsychotic (AP) use in the treatment of schizophrenia and the effect of introducing a new LAI (paliperidone palmitate [paliperidone-LAI]) in the Spanish province of Tarragona. Methods: This noninterventional, naturalistic, retrospective study included electronic medical record data from a large population-based database of 1,646 patients who were diagnosed with schizophrenia according to ICD-10 criteria and treated between January 2011 and December 2013...
March 23, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/28346753/association-between-diabetes-mellitus-hyperglycemia-and-peri-implant-diseases-systematic-review-and-meta-analysis
#9
REVIEW
Alberto Monje, Andres Catena, Wenche S Borgnakke
AIM: This systematic review investigates whether hyperglycemia/diabetes mellitus is associated with peri-implant diseases (peri-implant mucositis and peri-implantitis). MATERIALS AND METHODS: Electronic and manual literature searching was conducted. An a priori case definition for peri-implantitis was used as an inclusion criterion to minimize risk of bias. The Newcastle Ottawa Scale was used for quality assessment; random effect models were applied; and results were reported according to the PRISMA Statement...
March 27, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28346750/intuitive-understanding-of-%C3%AF-delocalization-in-loose-and-%C3%AF-localization-in-tight-helical-conformations-of-an-oligosilane-chain
#10
Milena Jovanovic, Dean Antic, David Rooklin, Annika Bande, Josef Michl
Conformational effects on σ-electron delocalization in oligosilanes are addressed by Hartree-Fock and time-dependent density functional theory (B3LYP, 6-311G**) at MP2 optimized geometries of permethylated uniformly helical linear oligosilanes (all-ω-SinR2n+2) up to n = 16 and for backbone dihedral angles ω = 55 - 180̊. The extent of σ delocalization is judged by the partition ratio of the highest occupied molecular orbital and is reflected in the dependence of its shape and energy and of UV absorption spectra on n...
March 27, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28346735/carbenes-as-electron-pair-donors-for-p%C3%A2-c-pnicogen-bonds
#11
Janet E Del Bene, Ibon Alkorta, Jose Elguero
Ab initio MP2/aug'-cc-pVTZ calculations have been performed on the P…C pnicogen-bonded complexes of the singlet carbene molecules C(NH2)2, C(OH)2, and cyclic C(OCH)2 [OHC] with the molecules H2XP for X = F, Cl, NC, OH, CH3, CN, CCH, and H. H2XP:C(NH2)2 and H2XP:C(OH)2 complexes have Cs symmetry and two different structures: one in which the symmetry plane of the complex and the local symmetry plane of the carbene are non-coplanar, and the other in which they are coplanar. The non-coplanar H2XP:C(NH2)2 and H2XP:C(OH)2 complexes arise only when X is one of the more electronegative substituents...
March 27, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28346729/comparison-of-the-safety-of-electrotome-harmonic-scalpel-and-ligasure-for-management-of-thyroid-surgery
#12
Xiaodong Yang, Jian Cao, Yichao Yan, Fangfang Liu, Tao Li, Long Han, Chunxiang Ye, Shuying Zheng, Shan Wang, Yingjiang Ye, Kewei Jiang
BACKGROUND: Energy-based surgical devices, including electrotome, the Harmonic scalpel, and LigaSure, have been widely applied in thyroid surgery, although a comparison of their safety and efficacy has not been reported yet. In this study, we investigated the feasibility of using hemostatic energy-based surgical devices during thyroid surgery in a canine model. METHODS: Twenty-four beagle dogs were randomly divided into the following groups: electrotome (30 kW), electrotome (15 kW), the Harmonic scalpel (output level 3), and LigaSure (middle gear)...
March 27, 2017: Head & Neck
https://www.readbyqxmd.com/read/28346645/facial-trauma-caused-by-electronic-cigarette-explosion
#13
Brian Vaught, Joseph Spellman, Anil Shah, Alexander Stewart, David Mullin
Electronic cigarettes are increasingly popular as a supposed safer alternative to tobacco cigarettes or a smoking cessation tool. Research and debate have focused primarily on possible adverse effects caused by the inhaled aerosol produced by electronic cigarettes and on smoking cessation efficacy. Few reports in the medical literature describe injuries secondary to device malfunction. We present a case of electronic cigarette explosion, with a projectile fracturing the patient's right naso-orbital-ethmoid complex and anterior and posterior frontal sinus tables, with frontal sinus outflow tract involvement...
March 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28346620/varied-rates-of-implementation-of-patient-centered-medical-home-features-and-residents-perceptions-of-their-importance-based-on-practice-experience
#14
M Patrice Eiff, Larry A Green, Geoff Jones, Alex Verdieck Devlaeminck, Elaine Waller, Eve Dexter, Miguel Marino, Patricia A Carney
BACKGROUND AND OBJECTIVES: Little is known about how the patient-centered medical home (PCMH) is being implemented in residency practices. We describe both the trends in implementation of PCMH features and the influence that working with PCMH features has on resident attitudes toward their importance in 14 family medicine residencies associated with the P4 Project. METHODS: We assessed 24 residency continuity clinics annually between 2007-2011 on presence or absence of PCMH features...
March 2017: Family Medicine
https://www.readbyqxmd.com/read/28346551/infrared-spectra-of-hscs-c-hscs-and-hcs2-produced-on-electron-bombardment-of-cs2-in-solid-para-hydrogen
#15
Masashi Tsuge, Yuan-Pern Lee
We report infrared (IR) spectra of HSCS(+), c-HSCS, HCS2(-), and other species produced on electron bombardment of a mixture of CS2 and para-hydrogen (p-H2) during deposition at 3.2 K. After maintenance of the deposited matrix in darkness for 12 h, the intensities of the absorption lines of HSCS(+) at 2477.2 (ν1), 1525.6 (ν2), and 919.6 cm(-1) (ν3) decreased through neutralization of HSCS(+) with trapped electrons. During this period, the intensities of the lines of HCS2(-) at 2875.7 (ν1), 1249.9 (ν5), 1003...
March 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28346458/revealing-the-reaction-mechanisms-of-li-o2-batteries-using-environmental-transmission-electron-microscopy
#16
Langli Luo, Bin Liu, Shidong Song, Wu Xu, Ji-Guang Zhang, Chongmin Wang
The performances of a Li-O2 battery depend on a complex interplay between the reaction mechanism at the cathode, the chemical structure and the morphology of the reaction products, and their spatial and temporal evolution; all parameters that, in turn, are dependent on the choice of the electrolyte. In an aprotic cell, for example, the discharge product, Li2O2, forms through a combination of solution and surface chemistries that results in the formation of a baffling toroidal morphology. In a solid electrolyte, neither the reaction mechanism at the cathode nor the nature of the reaction product is known...
March 27, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28346440/endocytic-proteins-are-partitioned-at-the-edge-of-the-clathrin-lattice-in-mammalian-cells
#17
Kem A Sochacki, Andrea M Dickey, Marie-Paule Strub, Justin W Taraska
Dozens of proteins capture, polymerize and reshape the clathrin lattice during clathrin-mediated endocytosis (CME). How or if this ensemble of proteins is organized in relation to the clathrin coat is unknown. Here, we map key molecules involved in CME at the nanoscale using correlative super-resolution light and transmission electron microscopy. We localize 19 different endocytic proteins (amphiphysin1, AP2, β2-arrestin, CALM, clathrin, DAB2, dynamin2, EPS15, epsin1, epsin2, FCHO2, HIP1R, intersectin, NECAP, SNX9, stonin2, syndapin2, transferrin receptor, VAMP2) on thousands of individual clathrin structures, generating a comprehensive molecular architecture of endocytosis with nanoscale precision...
March 27, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28346432/nanoscale-capillary-freezing-of-ionic-liquids-confined-between-metallic-interfaces-and-the-role-of-electronic-screening
#18
Jean Comtet, Antoine Niguès, Vojtech Kaiser, Benoit Coasne, Lydéric Bocquet, Alessandro Siria
Room-temperature ionic liquids (RTILs) are new materials with fundamental importance for energy storage and active lubrication. They are unusual liquids, which challenge the classical frameworks of electrolytes, whose behaviour at electrified interfaces remains elusive, with exotic responses relevant to their electrochemical activity. Using tuning-fork-based atomic force microscope nanorheological measurements, we explore here the properties of confined RTILs, unveiling a dramatic change of the RTIL towards a solid-like phase below a threshold thickness, pointing to capillary freezing in confinement...
March 27, 2017: Nature Materials
https://www.readbyqxmd.com/read/28346390/the-effect-and-mechanism-of-transdermal-penetration-enhancement-of-fu-s-cupping-therapy-new-physical-penetration-technology-for-transdermal-administration-with-traditional-chinese-medicine-tcm-characteristics
#19
Wei-Jie Xie, Yong-Ping Zhang, Jian Xu, Xiao-Bo Sun, Fang-Fang Yang
BACKGROUND: In this paper, a new type of physical penetration technology for transdermal administration with traditional Chinese medicine (TCM) characteristics is presented. Fu's cupping therapy (FCT), was established and studied using in vitro and in vivo experiments and the penetration effect and mechanism of FCT physical penetration technology was preliminarily discussed. METHODS: With 1-(4-chlorobenzoyl)-5-methoxy-2-methylindole-3-ylacetic acid (indomethacin, IM) as a model drug, the establishment of high, medium, and low references was completed for the chemical permeation system via in vitro transdermal tests...
March 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28346376/blend-hydrogel-microspheres-of-carboxymethyl-chitosan-and-gelatin-for-the-controlled-release-of-5-fluorouracil
#20
Vanarchi Rajini Kanth, Praveen B Kajjari, Priya M Madalageri, Sakey Ravindra, Lata S Manjeshwar, Tejraj M Aminabhavi
Carboxymethyl chitosan (CMCS) was synthesized and blended with gelatin (GE) to prepare hydrogel microspheres by w/o emulsion cross-linking in the presence of glutaraldehyde (GA), which acted as a cross-linker. 5-Fluorouracil (5-FU) was encapsulated to investigate its controlled release (CR) characteristics in acidic (pH 1.2) and alkaline (pH 7.4) buffer media. The microspheres which formed were spherical in nature, with smooth surfaces, as judged by the scanning electron microscopy (SEM). Fourier transform infrared spectroscopy (FTIR) confirmed the carboxymethylation of CS and the chemical stability of 5-FU in the formulations...
March 27, 2017: Pharmaceutics
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