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https://www.readbyqxmd.com/read/28803562/dopamine-receptor-d2-drd2-dopamine-transporter-solute-carrier-family-c6-member-4-slc6a3-and-catechol-o-methyltransferase-comt-genes-as-moderators-of-the-relation-between-maternal-history-of-maltreatment-and-infant-emotion-regulation
#1
Vanessa Villani, Jaclyn Ludmer, Andrea Gonzalez, Robert Levitan, James Kennedy, Mario Masellis, Vincenzo S Basile, Christine Wekerle, Leslie Atkinson
Although infants less than 18 months old are capable of engaging in self-regulatory behavior (e.g., avoidance, withdrawal, and orienting to other aspects of their environment), the use of self-regulatory strategies at this age (as opposed to relying on caregivers) is associated with elevated behavioral and physiological distress. This study investigated infant dopamine-related genotypes (dopamine receptor D2 [DRD2], dopamine transporter solute carrier family C6, member 4 [SLC6A3], and catechol-O-methyltransferase [COMT]) as they interact with maternal self-reported history of maltreatment to predict observed infant independent emotion regulation behavior...
August 14, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28802459/head-trunk-and-arm-posture-amplitude-and-variation-muscle-activity-sedentariness-and-physical-activity-of-3-to-5-year-old-children-during-tablet-computer-use-compared-to-television-watching-and-toy-play
#2
Erin K Howie, Pieter Coenen, Amity C Campbell, Sonia Ranelli, Leon M Straker
Young children (ages 3 to 5) are using mobile touchscreen technology, including tablet computers, yet little is known on the potential musculoskeletal and physical activity implications of its use. This within-subject laboratory study (n = 10) examined head, trunk and arm postures, upper trapezius muscle activity, and total body and upper limb physical activity during playing with tablets compared to during TV watching and playing with non-screen toys. Overall, this study found that during tablet play children had greater mean head, trunk and upper arm angles compared to both TV watching and toy play...
November 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28796537/heterosexual-women-s-anal-sex-attitudes-and-motivations-a-focus-group-study
#3
Kimberly R McBride
Focus group methods were used to explore heterosexual women's receptive anal sex attitudes and motivations. Behaviors under investigation included penile-anal intercourse (PAI), manual-anal stimulation, oral-anal contact, and the use of sex toys. A total of 33 self-identified heterosexual women ages 18 to 30 recruited from two metropolitan areas in the Midwestern United States participated in one of six focus groups. The findings suggest that women viewed heterosexual anal sex as an emerging norm. Attitudes and motivations were complex and varied by behavior...
August 10, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/28794284/genomic-profiling-of-er-breast-cancers-after-short-term-estrogen-suppression-reveals-alterations-associated-with-endocrine-resistance
#4
Jennifer M Giltnane, Katherine E Hutchinson, Thomas P Stricker, Luigi Formisano, Christian D Young, Monica V Estrada, Mellissa J Nixon, Liping Du, Violeta Sanchez, Paula Gonzalez Ericsson, Maria G Kuba, Melinda E Sanders, Xinmeng J Mu, Eliezer M Van Allen, Nikhil Wagle, Ingrid A Mayer, Vandana Abramson, Henry Gόmez, Monica Rizzo, Weiyi Toy, Sarat Chandarlapaty, Erica L Mayer, Jason Christiansen, Danielle Murphy, Kerry Fitzgerald, Kai Wang, Jeffrey S Ross, Vincent A Miller, Phillip J Stephens, Roman Yelensky, Levi Garraway, Yu Shyr, Ingrid Meszoely, Justin M Balko, Carlos L Arteaga
Inhibition of proliferation in estrogen receptor-positive (ER(+)) breast cancers after short-term antiestrogen therapy correlates with long-term patient outcome. We profiled 155 ER(+)/human epidermal growth factor receptor 2-negative (HER2(-)) early breast cancers from 143 patients treated with the aromatase inhibitor letrozole for 10 to 21 days before surgery. Twenty-one percent of tumors remained highly proliferative, suggesting that these tumors harbor alterations associated with intrinsic endocrine therapy resistance...
August 9, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28793211/design-of-elastic-networks-with-evolutionary-optimized-long-range-communication-as-mechanical-models-of-allosteric-proteins
#5
Holger Flechsig
Allosteric effects often underlie the activity of proteins, and elucidating generic design aspects and functional principles unique to allosteric phenomena represent a major challenge. Here an approach consisting of the in silico design of synthetic structures, which, as the principal element of allostery, encode dynamical long-range coupling among two sites, is presented. The structures are represented by elastic networks, similar to coarse-grained models of real proteins. A strategy of evolutionary optimization was implemented to iteratively improve allosteric coupling...
August 8, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28791153/population-patterns-in-world-s-administrative-units
#6
Oscar Fontanelli, Pedro Miramontes, Germinal Cocho, Wentian Li
Whereas there has been an extended discussion concerning city population distribution, little has been said about that of administrative divisions. In this work, we investigate the population distribution of second-level administrative units of 150 countries and territories and propose the discrete generalized beta distribution (DGBD) rank-size function to describe the data. After testing the balance between the goodness of fit and number of parameters of this function compared with a power law, which is the most common model for city population, the DGBD is a good statistical model for 96% of our datasets and preferred over a power law in almost every case...
July 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28780395/use-of-a-robotic-seal-as-a-therapeutic-tool-to-improve-dementia-symptoms-a-cluster-randomized-controlled-trial
#7
Wendy Moyle, Cindy J Jones, Jenny E Murfield, Lukman Thalib, Elizabeth R A Beattie, David K H Shum, Siobhan T O'Dwyer, M Cindy Mervin, Brian M Draper
OBJECTIVES: To test the effects of individual, nonfacilitated sessions with PARO (version 9), when compared against a look-alike plush toy and usual care, on the emotional and behavioral symptoms of dementia for people living in long-term care facilities. DESIGN: Parallel, 3-group, cluster-randomized controlled trial conducted between June 14, 2014, and May 16, 2015. SETTING: Twenty-eight long-term care facilities operated by 20 care organizations located in South-East Queensland, Australia...
August 2, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28777611/self-organized-resonance-during-search-of-a-diverse-chemical-space
#8
Tal Kachman, Jeremy A Owen, Jeremy L England
Recent studies of active matter have stimulated interest in the driven self-assembly of complex structures. Phenomenological modeling of particular examples has yielded insight, but general thermodynamic principles unifying the rich diversity of behaviors observed have been elusive. Here, we study the stochastic search of a toy chemical space by a collection of reacting Brownian particles subject to periodic forcing. We observe the emergence of an adaptive resonance in the system matched to the drive frequency, and show that the increased work absorption by these resonant structures is key to their stabilization...
July 21, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28771868/aboriginal-parent-support-a-partnership-approach
#9
Ailsa Munns, Christine Toye, Desley Hegney, Marion Kickett, Rhonda Marriott, Roz Walker
AIMS AND OBJECTIVES: This study was positioned within a larger action research study relating to a peer-led Aboriginal home visiting parent support program in an urban Western Australian setting. The aims for this study component were to identify program elements, exploring participants' perceptions of the program's suitability, feasibility, acceptability and effectiveness to inform program model recommendations and add to the body of knowledge on effective Aboriginal peer-led program models...
August 3, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28766867/does-temperament-underlie-infant-novel-food-responses-continuity-of-approach-withdrawal-from-6-to-18%C3%A2-months
#10
Kameron J Moding, Cynthia A Stifter
This study investigated whether temperamental approach-withdrawal underlies infants' responses to novel foods. Data were drawn from a longitudinal study of mother-infant dyads (n = 136). Approach-withdrawal responses to novel foods and novel toys were coded when infants were 6 and 12 months of age. When infants were 18 months of age, approach-withdrawal behaviors, positive affect, and negative affect were used in a latent profile analysis to identify groups of toddlers who exhibited similar responses to novelty...
August 2, 2017: Child Development
https://www.readbyqxmd.com/read/28764666/a-mega-ethnography-of-eleven-qualitative-evidence-syntheses-exploring-the-experience-of-living-with-chronic-non-malignant-pain
#11
Fran Toye, Kate Seers, Erin Hannink, Karen Barker
BACKGROUND: Each year over five million people develop chronic non-malignant pain and can experience healthcare as an adversarial struggle. The aims of this study were: (1) to bring together qualitative evidence syntheses that explore patients' experience of living with chronic non-malignant pain and develop conceptual understanding of what it is like to live with chronic non-malignant pain for improved healthcare; (2) to undertake the first mega-ethnography of qualitative evidence syntheses using the methods of meta-ethnography...
August 1, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28761666/radial-and-ulnar-fracture-treatment-with-paraosseous-clamp-cerclage-stabilisation-technique-in-17-toy-breed-dogs
#12
George Manchi, Mathias M Brunnberg, Muhammad Shahid, Ahmad Al Aiyan, Eric Chow, Leo Brunnberg, Silke Stein
OBJECTIVE: Description of surgical technique, complications and outcome of radius/ulna fractures in toy and miniature breed dogs treated with the paraosseous clamp-cerclage stabilisation (PCCS) method. STUDY DESIGN: Retrospective study. METHODS: Clinical records of small breed dogs with fractures of the radius and ulna were reviewed between January 2011 and January 2016. Inclusion criteria were bodyweight of ≤3.5 kg, fracture of the radius and ulna of one or two limbs without previous repair attempts, available follow-up information, and the use of PCCS for repair of the fracture as the sole method of fixation...
2017: Veterinary Record Open
https://www.readbyqxmd.com/read/28760154/dementia-knowledge-assessment-scale-dkas-confirmatory-factor-analysis-and-comparative-subscale-scores-among-an-international-cohort
#13
Michael J Annear, Chris Toye, Kate-Ellen J Elliott, Frances McInerney, Claire Eccleston, Andrew Robinson
BACKGROUND: Dementia is a life-limiting condition that is increasing in global prevalence in line with population ageing. In this context, it is necessary to accurately measure dementia knowledge across a spectrum of health professional and lay populations with the aim of informing targeted educational interventions and improving literacy, care, and support. Building on prior exploratory analysis, which informed the development of the preliminarily valid and reliable version of the Dementia Knowledge Assessment Scale (DKAS), a Confirmatory Factor Analysis (CFA) was performed to affirm construct validity and proposed subscales to further increase the measure's utility for academics and educators...
July 31, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28758412/onset-of-depressed-heart-work-is-correlated-with-the-increased-heart-rate-and-shorten-qt-interval-in-high-carbohydrate-fed-overweight-rats
#14
Aysegul Toy Durak, Yusuf Olgar, Erkan Tuncay, Irem Karaomerlioglu, Gizem Kayki Mutlu, Ebru Arioglu Inan, Vecdi Melih Altan, Belma Turan
Mechanical activity of the heart is adversely affected with metabolic syndrome (MetS) characterized with increased body-mass and marked insulin-resistance. Herein, we examined effects of high-carbohydrate intake on cardiac functional abnormalities via evaluating in situ heart-work, heart-rate and electrocardiograms (ECG) in rats. MetS is induced in Wistar male rats by adding 32% sucrose for 22-24 weeks and confirmed with insulin-resistance, increased body-weight, blood glucose and insulin, systolic and diastolic blood pressures besides significant left ventricular integrity-lost and increased connective-tissue around myofibrils...
July 30, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28753334/no-hypersignaling-principle
#15
Michele Dall'Arno, Sarah Brandsen, Alessandro Tosini, Francesco Buscemi, Vlatko Vedral
A paramount topic in quantum foundations, rooted in the study of the Einstein-Podolsky-Rosen (EPR) paradox and Bell inequalities, is that of characterizing quantum theory in terms of the spacelike correlations it allows. Here, we show that to focus only on spacelike correlations is not enough: we explicitly construct a toy model theory that, while not contradicting classical and quantum theories at the level of spacelike correlations, still displays an anomalous behavior in its timelike correlations. We call this anomaly, quantified in terms of a specific communication game, the "hypersignaling" phenomena...
July 14, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28752143/the-effects-of-pre-obesity-on-quality-of-life-disease-activity-and-functional-status-in-patients-with-ankylosing-spondylitis
#16
Seyma Toy, Davut Ozbag, Zuhal Altay
OBJECTIVE: This study was an investigation of effects of pre-obesity on clinical characteristics and quality of life in patients with ankylosing spondylitis (AS). METHODS: Total of 28 AS patients and 30 age- and sex-matched healthy controls were included in the study. Patients and controls with any systemic inflammatory disease and/or cognitive and mental problems were excluded. Disease activity and functional capacity were measured using the Bath Ankylosing Spondylitis Disease Activity Index and Bath Ankylosing Spondylitis Functional Index...
2017: Northern Clinics of Istanbul
https://www.readbyqxmd.com/read/28748924/significant-and-variable-linear-polarization-during-the-prompt-optical-flash-of-grb-160625b
#17
E Troja, V M Lipunov, C G Mundell, N R Butler, A M Watson, S Kobayashi, S B Cenko, F E Marshall, R Ricci, A Fruchter, M H Wieringa, E S Gorbovskoy, V Kornilov, A Kutyrev, W H Lee, V Toy, N V Tyurina, N M Budnev, D A H Buckley, J González, O Gress, A Horesh, M I Panasyuk, J X Prochaska, E Ramirez-Ruiz, R Rebolo Lopez, M G Richer, C Román-Zúñiga, M Serra-Ricart, V Yurkov, N Gehrels
Newly formed black holes of stellar mass launch collimated outflows (jets) of ionized matter that approach the speed of light. These outflows power prompt, brief and intense flashes of γ-rays known as γ-ray bursts (GRBs), followed by longer-lived afterglow radiation that is detected across the electromagnetic spectrum. Measuring the polarization of the observed GRB radiation provides a direct probe of the magnetic fields in the collimated jets. Rapid-response polarimetric observations of newly discovered bursts have probed the initial afterglow phase, and show that, minutes after the prompt emission has ended, the degree of linear polarization can be as high as 30 per cent-consistent with the idea that a stable, globally ordered magnetic field permeates the jet at large distances from the central source...
July 26, 2017: Nature
https://www.readbyqxmd.com/read/28744242/complex-problem-solving-what-it-is-and-what-it-is-not
#18
Dietrich Dörner, Joachim Funke
Computer-simulated scenarios have been part of psychological research on problem solving for more than 40 years. The shift in emphasis from simple toy problems to complex, more real-life oriented problems has been accompanied by discussions about the best ways to assess the process of solving complex problems. Psychometric issues such as reliable assessments and addressing correlations with other instruments have been in the foreground of these discussions and have left the content validity of complex problem solving in the background...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28741413/modulating-children-s-manual-preference-through-spontaneous-nondominant-hand-use
#19
Juliana Maia Garcia, Luis Augusto Teixeira
We evaluated the effect of repeated use of the nonpreferred hand on young children's manual preference by positioning toys in the left hemifield in egocentric coordinates to induce right-handed 4- to 5-year-olds to use their left hands spontaneously. We induced motor activities in the laterally biased workspace by presenting tasks in a ludic context over different days, similar to their daily kindergarten experience. Preceding and following these lateralized experiences, the children were tested on a task requiring reaching, grasping, and inserting cards into a slot...
January 1, 2017: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/28738761/peer-led-aboriginal-parent-support-program-development-for-vulnerable-populations-with-participatory-action-research
#20
Ailsa Munns, Christine Toye, Desley Hegney, Marion Kickett, Rhonda Marriott, Roz Walker
BACKGROUND: Participatory action research (PAR) is a credible, culturally appropriate methodology that can be used to effect collaborative change within vulnerable populations. AIM/OBJECTIVE: This PAR study was undertaken in a Western Australian metropolitan setting to develop and evaluate the suitability, feasibility and effectiveness of an Aboriginal peer-led home visiting programme. A secondary aim, addressed in this paper, was to explore and describe research methodology used for the study and provide recommendations for its implementation in other similar situations...
August 2, 2017: Contemporary Nurse
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