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https://www.readbyqxmd.com/read/29150895/rapid-and-green-determination-of-58-fragrance-allergens-in-plush-toys
#1
Zhijuan Wang, Qing Zhang, Haiyu Li, Qing Lv, Wan Wang, Hua Bai
This paper presents a simple, rapid, and green method based on a static headspace gas chromatography with mass spectrometry for determining 58 fragrance allergens in plush toys. This study is the first to meet the requirement for simultaneously determining 66 fragrances, except for eight natural extracts restricted by the European Toy Safety Directive 2009/48/EC. A minimal amount of sample (20 mg) and acetone solvent (20 μL) were placed in a headspace vial. A gas-solid equilibration of fragrances between the headspace and the sample was achieved within 10 min under the vapor atmosphere of acetone at 200°C, which allowed the fragrances in the sample to be measured by gas chromatography with mass spectrometry...
November 17, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29150742/associations-between-nucleus-size-and-immunohistochemical-galectin-3-cytokeratine-19-and-hbme-1-markers-in-thyroid-papillary-carcinoma-a-morphometric-analyze
#2
Hatice Toy, Ozlem Etli, Zeliha Esin Celik, Arsenal Sezgin Alikanoglu
This study aimed to evaluate the morphometric measurements in cases with papillary thyroid carcinoma, and determine a cut-off value to support diagnosis. Fifty cases with a diagnosis of papillary thyroid carcinoma (PTC) were included in the study with their Galectine-3, CK-19 and HBME-1 immunohistochemical staining results. Demographic and clinical data gathered from pathology reports, which included demographic information such as patients' sex, age, macroscopic tumor size, number of tumor focuses; prognostic parameters such as lenfovascular invasion, perineural invasion, thyroid capsule invasion; and results of immunohistochemical CK- 19, Galectin-3 and HBME-1 staining...
November 17, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29147548/automaticity-in-stimulus-parity-synaesthesia
#3
Tsvetomira Dumbalska, Rebekah C White, Mihaela D Duta, Kate Nation
Automaticity is a defining characteristic of synaesthesia. Here, we assess for automaticity in stimulus-parity synaesthesia; a subtype that has been documented only 3 times in the literature. Synaesthete R experiences many (nonnumerical) stimuli as being odd or even. She described a toy shape-sorter, which paired odd shapes with even colour slots (and vice versa) and relayed difficulties with the incongruency created by this simple toy. Inspired by this anecdote, we devised a computerised task in which Synaesthete R (and 10 control participants) indicated the location of a target shape, which was presented on a coloured bar...
November 2017: I-Perception
https://www.readbyqxmd.com/read/29145915/keeping-it-simple-the-grammatical-properties-of-shared-book-reading
#4
Claire H Noble, Thea Cameron-Faulkner, Elena Lieven
The positive effects of shared book reading on vocabulary and reading development are well attested (e.g., Bus, van Ijzendoorn, & Pellegrini, 1995). However, the role of shared book reading in grammatical development remains unclear. In this study, we conducted a construction-based analysis of caregivers' child-directed speech during shared book reading and toy play and compared the grammatical profile of the child-directed speech generated during the two activities. The findings indicate that (a) the child-directed speech generated by shared book reading contains significantly more grammatically rich constructions than child-directed speech generated by toy play, and (b) the grammatical profile of the book itself affects the grammatical profile of the child-directed speech generated by shared book reading...
November 17, 2017: Journal of Child Language
https://www.readbyqxmd.com/read/29144736/inference-of-calmodulin-s-ca2-dependent-free-energy-landscapes-via-gaussian-mixture-model-validation
#5
Annie M Westerlund, Tyler J Harpole, Christian Blau, Lucie Delemotte
A free energy landscape estimation-method based on the well-known Gaussian mixture model (GMM) is used for comparing the efficiency of thermally enhanced sampling methods with respect to regular molecular dynamics. The simulations are carried out on two binding states of calmodulin and the free energy estimation method is compared to other estimators using a toy model. We show that GMM with cross-validation provides a robust estimate that is not subject to overfitting. The continuous nature of Gaussians provides better estimates on sparse data than canonical histogramming...
November 16, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29142158/computed-tomography-magnetic-resonance-imaging-and-a-novel-surgical-approach-of-atlanto-axial-instability-with-incongruence-in-dogs
#6
Mario Dolera, Luca Malfassi, Simone Pavesi, Sara Finesso, Giovanni Mazza, Silvia Marcarini, Massimo Sala, Nancy Carrara, Cristina Bianchi, Jennifer M Gambino
Atlanto-axial (AA) instability due to ligament insufficiency is a common cause of cervical spinal cord compression in toy breeds. However, in some dogs a difference in size between the atlas and the axis leads to joint incongruence that exacerbates AA subluxation and makes surgical treatment challenging. Twelve dogs with AA instability with incongruence were enrolled in a single institution prospective observational study. Computed tomography (CT) and magnetic resonance imaging (MRI) of the AA joint were compared to a retrospectively reviewed control group...
November 15, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29142149/liposarcoma-of-the-spermatic-cord-in-a-toy-poodle
#7
Daji Noh, Wooson Choi, Woochan Son, Manhee Lee, Seungchun Park, Kija Lee
Liposarcoma of the spermatic cord is extremely rare in dogs and humans. This report describes the clinical signs, typical diagnostic imaging including ultrasound and computed tomography, and treatment of a liposarcoma of the spermatic cord of a Toy Poodle confirmed by histological examination after a surgical procedure. This case highlights the importance of preoperative diagnostic imaging and histopathological examination in dogs with an inguinal or scrotal mass.
November 14, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29141653/test-of-a-workforce-development-intervention-to-expand-opioid-use-disorder-treatment-pharmacotherapy-prescribers-protocol-for-a-cluster-randomized-trial
#8
Todd Molfenter, Hannah K Knudsen, Randy Brown, Nora Jacobson, Julie Horst, Mark Van Etten, Jee-Seon Kim, Eric Haram, Elizabeth Collier, Sanford Starr, Alexander Toy, Lynn Madden
BACKGROUND: Overdoses due to non-medical use of prescription opioids and other opiates have become the leading cause of accidental deaths in the USA. Buprenorphine and extended-release naltrexone are key evidence-based pharmacotherapies available to addiction treatment providers to address opioid use disorder (OUD) and prevent overdose deaths. Treatment organizations' efforts to provide these pharmacotherapies have, however, been stymied by limited success in recruiting providers (physicians, nurse practitioners, and physician assistants) to prescribe these medications...
November 15, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/29138976/-eyeball-perforation-of-a%C3%A2-7-year-old-girl-caused-by-the-must-have-office-toy-2017-the-potential-risk-of-injury-by-a-spinning-toy-fidget-spinner
#9
A Nessmann, K Chaloupka, C Böni
A 7-year-old girl presented to the emergency department of the eye clinic with an eyeball perforation with iris prolapse and corneal as well as scleral wounds of the left eye caused by a spinning toy (fidget spinner). A surgical wound inspection with iris reposition and corneal and scleral suture were performed without delay. This case report demonstrates the potential risk of this popular toy.
November 14, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29137551/environmental-manipulations-as-an-effective-alternative-treatment-to-reduce-endometriosis-progression
#10
Annelyn Torres-Reverón, Leslie L Rivera, Idhaliz Flores, Caroline B Appleyard
Treatments for endometriosis include pharmacological or surgical procedures that produce significant side effects. We aimed to determine how environmental enrichment (EE) could impact the progression of endometriosis using the autotransplantation rat model. Female rats were exposed to EE (endo-EE: toys and nesting materials, 4 rats per cage, larger area enclosure) or no enrichment (endo-NE: 2 rats per cage) starting on postnatal day 21. After 8 weeks, sham surgery or surgical endometriosis was induced by suturing uterine horn tissue next to the intestinal mesentery, then allowed to progress for 60 days during which EE or NE continued...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29131817/characterizing-steady-states-of-genome-scale-metabolic-networks-in-continuous-cell-cultures
#11
Jorge Fernandez-de-Cossio-Diaz, Kalet Leon, Roberto Mulet
In the continuous mode of cell culture, a constant flow carrying fresh media replaces culture fluid, cells, nutrients and secreted metabolites. Here we present a model for continuous cell culture coupling intra-cellular metabolism to extracellular variables describing the state of the bioreactor, taking into account the growth capacity of the cell and the impact of toxic byproduct accumulation. We provide a method to determine the steady states of this system that is tractable for metabolic networks of arbitrary complexity...
November 13, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29130483/contributions-of-infant-vagal-regulation-at-1-month-to-subsequent-joint-attention-abilities
#12
Vera Mateus, Sara Cruz, Fernando Ferreira-Santos, Ana Osório, Adriana Sampaio, Carla Martins
Since birth, humans develop an ability to regulate their inner states and behaviors, when facing demanding situations, in order to restore calmness and engage with other persons and the surrounding environment. The present study analyzed whether 1-month infant vagal regulation to auditory stimuli was associated with later joint attention abilities-responding to and initiating joint attention-in interaction with their mothers. Twenty-three infants were assessed and measures of respiratory sinus arrhythmia-RSA (baseline and vagal tone change during auditory stimulation) were used as index of vagal regulation...
November 12, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/29127800/regulation-of-chemicals-in-children-s-products-how-u-s-and-eu-regulation-impacts-small-markets
#13
Maya Negev, Tamar Berman, Shay Reicher, Simona Balan, Anna Soehl, Shula Goulden, Ruti Ardi, Yaniv Shammai, Laura Hadar, Arlene Blum, Miriam L Diamond
Toys and children's products may contain trace metals and organic compounds that are potentially harmful to the health and development of infants and young children. Intergovernmental organizations and individual countries regulate chemicals in consumer products, but a coordinated international approach is lacking. This paper examines the implications of chemical regulation in children's products in large markets for a smaller market, namely Israel. We compared chemical regulations in children's products in the U...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29126512/what-is-an-endocrine-disruptor
#14
Claude Monneret
Endocrine disrupting chemicals (EDCs) and potential EDCs are mostly man-made found in various materials. By interfering with the body's endocrine system, endocrine disruptors produce adverse developmental, reproductive, neurological, and immune effects in humans, abnormal growth patterns and neurodevelopmental delays in children. Thus, diethylstilbestrol (DES) a non-steroidal estrogen, which is regarded as a proof of concept, induces clear cell carcinoma among young women. EDCS may be found in plastic bottles and metal food cans (BPA), medical devices (phthalates), detergents, flame retardants (polybrominated diphenyl ethers), food (BPA), toys (phthalates), cosmetics and drugs (parabens), and pesticides (alkyl phenols such as nonylphenol)...
September 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/29123603/paediatric-appropriate-facilities-in-emergency-departments-of-community-hospitals-in-ontario-a-cross-sectional-study
#15
Muhammad Akhter Hamid, Sohaib Siddiqui, Jabeen Fayyaz, Ayesha Chandna, Aliya Ariz, Joe Butchey, Elancheliyan Ambalavanar, Niraj Mistry, Aftab Muhammad Azad, Junaid A Bhatti, Dennis Scolnik
BACKGROUND: We assessed whether the paediatric-appropriate facilities were available at Emergency Departments (ED) in community hospitals in a Canadian province. METHODS: We conducted a cross-sectional survey of EDs in community hospitals in Ontario, Canada that had inpatient paediatric facilities and a neonatal intensive care unit. Key informants were ED chiefs, clinical educators, or managers. The survey included questions about paediatric facilities related to environment, triage, training, and staff in EDs...
2017: World Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29122943/onur-kanisicak-from-toy-tinkerer-to-scientific-innovator
#16
Pam Goldberg-Smith
No abstract text is available yet for this article.
November 10, 2017: Circulation Research
https://www.readbyqxmd.com/read/29122348/associations-of-urinary-phthalate-metabolites-with-residential-characteristics-lifestyles-and-dietary-habits-among-young-children-in-shanghai-china
#17
Chenxi Liao, Wei Liu, Jialing Zhang, Wenming Shi, Xueying Wang, Jiao Cai, Zhijun Zou, Rongchun Lu, Chanjuan Sun, Heng Wang, Chen Huang, Zhuohui Zhao
Exposure to household phthalates has been reported to have adverse effects on children's health. In this paper, we used phthalate metabolites in the first morning urine as indicators of household phthalate exposures and examined their associations with residential characteristics, lifestyles and dietary habits among young children. During 2013-2014, we collected morning urines from children aged 5-10years in Shanghai, China and obtained the related information about analyzed factors in this study by questionnaires...
November 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29121525/psychometric-properties-of-the-affordances-in-the-home-environment-for-motor-development-inventory-for-use-with-iranian-children-aged-18-42-months
#18
Saeed Valadi, Carl Gabbard, Elahe Arabameri, Ali Kashi, Abdollah Ghasemi
OBJECTIVE: The aim of this study was to translate the original English language version of the Affordances in the Home Environment for Motor Development (AHEMD) inventory and test its psychometric properties for use with Iranian children aged 18-42 months. METHODS: For this purpose, the tool was translated into Farsi (a Persian language) using the forward-backward translation method and some of its psychometric properties were examined. Multistage stratified-cluster sampling was used to study 1019 families having children aged 18-42 months from among the regional divisions of Tehran urban community health centers...
November 7, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/29119813/school-age-children-s-perception-of-the-hospital-experience
#19
Handan Boztepe, Sevil Çınar, Ayşe Ay
In order to determine the perception of hospital experiences among school-age children's (6-12 years), a descriptive and cross-sectional study was performed in 130 children hospitalized in a pediatric hospital with different diagnoses. Data were collected using a pediatric information form, questionnaire form, scale for attitudes towards hospital and healthcare personnel, and sources of anxiety generating thoughts scale (SAGTS). Children's expectations of the nurses were to be well treated (62%), to perform painless procedures (20%), to play games together (12%), to be capable of their job (10%), and to be cheerful (10%)...
June 2017: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
https://www.readbyqxmd.com/read/29119507/systems-biology-modeling-of-nonlinear-cancer-dynamics
#20
Christian Cherubini, Simonetta Filippi, Alessandro Loppini
Systems Biology represents nowadays a promising standard framework for natural and human sciences to attack complicated problems involving Life. Here a particular application of such a program is discussed in the case of Cancer, by using a basic toy model for solid tumor spread for framing together two apparently different conceptual leading paradigms of Oncogenesis.
2018: Methods in Molecular Biology
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