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Ugochukwu N Ikeogu, Fabrice Davrieux, Dominique Dufour, Hernan Ceballos, Chiedozie N Egesi, Jean-Luc Jannink
Portable Vis/NIRS are flexible tools for fast and unbiased analyses of constituents with minimal sample preparation. This study developed calibration models for dry matter content (DMC) and carotenoids in fresh cassava roots using a portable Vis/NIRS system. We examined the effects of eight data pre-treatment combinations on calibration models and assessed calibrations on processed and intact root samples. We compared Vis/NIRS derived-DMC to other phenotyping methods. The results of the study showed that the combination of standard normal variate and de-trend (SNVD) with first derivative calculated on two data points and no smoothing (SNVD+1111) was adequate for a robust model...
2017: PloS One
Volha Zabela, Timm Hettich, Götz Schlotterbeck, Laurin Wimmer, Marko D Mihovilovic, Fabrice Guillet, Belkacem Bouaita, Bénédicte Shevchenko, Matthias Hamburger, Mouhssin Oufir
In a screening of natural products for allosteric modulators of GABAA receptors (γ-aminobutyric acid type A receptor), piperine was identified as a compound targeting a benzodiazepine-independent binding site. Given that piperine is also an activator of TRPV1 (transient receptor potential vanilloid type 1) receptors involved in pain signaling and thermoregulation, a series of piperine analogs were prepared in several cycles of structural optimization, with the aim of separating GABAA and TRPV1 activating properties...
December 2, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Hao-Yang Mi, Xin Jing, Emily Yu, Xiaofeng Wang, Qian Li, Lih-Sheng Turng
The success of blood vessel transplants with vascular scaffolds (VSs) highly depends on their structure and mechanical properties. The fabrication of small diameter vascular scaffolds (SDVSs) mimicking the properties of native blood vessels has been a challenge. Herein, we propose a facile method to fabricate thermoplastic polyurethane (TPU)/polycaprolactone (PCL) hybrid SDVSs via electrospinning using a modified rotating collector. By varying the ratio between the TPU and the PCL, and changing the electrospinning volume, SDVSs with a wavy configuration and different properties could be obtained...
December 1, 2017: Journal of the Mechanical Behavior of Biomedical Materials
Dawei Liu, Rong Qiang, Yunchen Du, Ying Wang, Chunhua Tian, Xijiang Han
A series of magnetic FeCo alloy/carbon composites have been successfully prepared through in situ pyrolysis of Prussian blue analogues (PBAs) with different Fe/Co ratios. The Fe/Co ratio can affect the crystalline phase, particle size, and magnetic property of the FeCo alloy particles, as well as the relative graphitization degree of the carbon frameworks. As a result, the electromagnetic functions of these composites will be highly associated with the Fe/Co ratio, where high Co content is beneficial to the formation of strong dielectric loss and moderate Co content can facilitate the magnetic loss...
December 6, 2017: Journal of Colloid and Interface Science
Jianqiang Chen, Chenyang Zhu, Zhen Yang, Yiying Yue, Ping Wang, Takuya Kitaoka
Lack of deep understanding of nanoparticles (NPs) actions in oil/water interface set an obstacle to practical applications of Pickering emulsions. Fluorescence labels by incorporation of carbon dots (CDs) into poly(N-isopropylacrylamide) (PNIPAM) matrix can not only mark the action of PNIPAM-based NPs in the interface, but also reflect the colloidal morphologies of PNIPAM. In this work, we employed coaxial electrospraying for fabricating core-shell nanospheres of cellulose acetate encapsulated by PNIPAM and facile incorporation of CDs in PNIPAM shell was achieved simultaneously...
December 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Nadzeya A Kukhta, Tomas Matulaitis, Dmytro Volyniuk, Khrystyna Ivaniuk, Pavlo Turyk, Pavlo Stakhira, Juozas Vidas Grazulevicius, Andrew P Monkman
Elaboration of the appropriate host materials proved to be not less important for the fabrication of a highly efficient OLED, than the design of emitters. In present work we show how by simple variation of molecular structure both blue emitters exhibiting delayed fluorescence and ambipolar high triplet energy hosts can be obtained. The compounds with para-junction revealed higher thermal stability (TID up to 480 oC), lower ionization potentials (5.51-5.60 eV), exclusively hole transport and higher photoluminescence quantum efficiencies (0...
December 11, 2017: Journal of Physical Chemistry Letters
Wolfgang Dohle, Fabrice L Jourdan, Gregory Menchon, Andrea E Prota, Paul A Foster, Pascoe Mannion, Ernest Hamel, Mark P Thomas, Philip G Kasprzyk, Eric Ferrandis, Michel O Steinmetz, Mathew P Leese, Barry V L Potter
Quinazolinone-based anti-cancer agents were designed, decorated with functional groups from a 2-methoxyestradiol-based microtubule disruptor series, incorporating the aryl sulfamate motif of steroid sulfatase (STS) inhibitors. The steroidal AB-ring system was mimicked, favoring conformations with an N-2 substituent occupying D-ring space. Evaluation against breast and prostate tumor cell lines identified 7b with DU-145 anti-proliferative activity (GI50 300 nM). A preliminary structure-activity relationship afforded compounds (e...
December 11, 2017: Journal of Medicinal Chemistry
Paul F Smith, Alexander B Brady, Seung-Yong Lee, Andrea M Bruck, Eric Dooryhee, Lijun Wu, Yimei Zhu, Kenneth J Takeuchi, Esther S Takeuchi, Amy C Marschilok
α-MnO2 structured materials are generally classified as semi-conductors, thus we present a strategy to increase electro-chemical utilization through design of a conductive material interface. Surface treatment of silver hollandite (AgxMn8O16) with Ag+ (Ag2O) provides significant benefit to the resultant electrochemistry, including a 2-4 fold decreased charge transfer resistance, 2-fold increase in deliverable energy den-sity at high rate, and 2-6 fold increased in effective lithium ion diffusion. The improved function of this designed inter-face relative to conventional electrode fabrication strategies is highlighted...
December 11, 2017: ACS Applied Materials & Interfaces
M Giulbudagian, S Hönzke, J Bergueiro, D Işık, F Schumacher, S Saeidpour, S B Lohan, M C Meinke, C Teutloff, M Schäfer-Korting, G Yealland, B Kleuser, S Hedtrich, M Calderón
Highly hydrophilic, responsive nanogels are attractive as potential systems for the topical delivery of bioactives encapsulated in their three-dimensional polymeric scaffold. Yet, these drug carrier systems suffer from drawbacks for efficient delivery of hydrophobic drugs. Addressing this, β-cyclodextrin (βCD) could be successfully introduced into the drug carrier systems by exploiting its unique affinity toward dexamethasone (DXM) as well as its role as topical penetration enhancer. The properties of βCD could be combined with those of thermoresponsive nanogels (tNGs) based on dendritic polyglycerol (dPG) as a crosslinker and linear thermoresponsive polyglycerol (tPG) inducing responsiveness to temperature changes...
December 11, 2017: Nanoscale
Yong Zhang, Sifeng Mao, Yuma Suzuki, Yumi Tanaka, Masato Kawaguchi, Weifei Zhang, Hulie Zeng, Hizuru Nakajima, Ming Yang, Katsumi Uchiyama
Elaborately programmed silver nanowire arrays can be prepared using a tapered push-pull nozzle system (TPPNS), which is used to directly write micro-nano wires on a substrate via a two-reagent reaction in the diffusion mixing region. The wires could be precisely positioned on the substrate and their width could be freely controlled from the micro to the nano scale, indicating an advance in the methodologies of controlling and fabricating nanowires. The as-prepared silver three-electrode device can serve as a three-electrode sensor...
December 11, 2017: Chemical Communications: Chem Comm
Linjing Xu, Alison E Seline, Braden Leigh, Mark Ramirez, C Allan Guymon, Marlan R Hansen
HYPOTHESIS: Microtopographical patterns generated by photopolymerization of methacrylate polymer systems will direct growth of neurites from adult neurons, including spiral ganglion neurons (SGNs). BACKGROUND: Cochlear implants (CIs) provide hearing perception to patients with severe to profound hearing loss. However, their ability to encode complex auditory stimuli is limited due, in part, to poor spatial resolution caused by spread of the electrical currents in the inner ear...
January 2018: Otology & Neurotology
Yanlin Zhang, Robert W Cattrall, Spas D Kolev
This paper reports on a novel microfluidic technique for the fabrication of microspheres of synthetic polymers including poly(vinyl chloride) (PVC), poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP), poly(lactic acid) (PLA), and polystyrene (PS). The polymers are dissolved in tetrahydrofuran (THF) and the method is based on the diminished solubility of THF in a 20% (w/v) NaCl solution which allows the formation of droplets of the polymer solution. These polymer solution droplets are generated in a microfluidic system and their desolvation is accomplished within seconds by allowing the droplets to rise by buoyancy through a NaCl solution with a concentration lower than 15%...
December 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Salih Zeki Bas, Cian Cummins, Dipu Borah, Mustafa Ozmen, Michael A Morris
A new enzyme-free sensor based on iron oxide (Fe3O4) nanodots fabricated on an indium tin oxide (ITO) substrate via a block copolymer (BCP) template was developed for high sensitive and selective detection of hydrogen peroxide (H2O2). The self-assembly based process described here for Fe3O4 formation is a simple, cost effective, and reproducible process. The H2O2¬ response of the fabricated electrodes was linear from 2.5×10-3 to 6.5 mM with a sensitivity of 191.6 µA mM-1cm-2 and a detection limit of 1.1×10-3 mM...
December 11, 2017: Analytical Chemistry
Jun Wang, Qiang-Sheng Zhang, Wei Dou, Alexander M Kirillov, Wei-Sheng Liu, Cong Xu, Cai-Ling Xu, Ran Fang, Li-Zi Yang
A trifunctional aromatic building block (H2L) containing three different types of functional groups (carboxyl C([double bond, length as m-dash]O)OH, aldehyde C([double bond, length as m-dash]O)H, and O-ether) was applied for the hydrothermal synthesis of two novel lanthanide 2D coordination polymers [Ln(μ-HL)(μ3-L)(phen)]n {Ln = Tb (1) and Eu (2); H2L = 5-methoxy-(4-benzaldehyde)-1,3-benzene dicarboxylic acid; phen = 1,10-phenanthroline}. Both compounds 1 and 2 are isostructural and reveal very complicated 2D metal-organic double layers with the 3,4L27 topology...
December 11, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Hongfei Ye, Yonggang Zheng, Lili Zhou, Junfei Zhao, Hongwu Zhang, Zhen Chen
Polar water molecules exhibit extraordinary phenomena under nanoscale confinement. Through the application of an electric field, a water-filled carbon nanotube (CNT) that has been successfully fabricated in the laboratory is expected to have distinct responses to the external electricity. Here, we examine the effect of electric field direction on the mechanical property of water-filled CNTs. It is observed that a longitudinal electric field enhances, but the transverse electric field reduces the elastic modulus and critical buckling stress of water-filled CNTs...
December 11, 2017: Nanotechnology
Mohamed Shaker Salem, Felipe Tejo, Robert Zierold, Philip Sergelius, Josep M Montero Moreno, Detlef Görlitz, Kornelius Nielsch, Juan Escrig
Straight magnetic nanowires composed of nickel and permalloy segments having different diameters are synthesized using a promising approach. This approach involves the controlled electrodeposition of each magnetic material into specially designed diameter-modulated porous alumina templates. Standard alumina templates are exposed to pore widening followed by a protective coating of the pore wall with ultrathin silica and further anodization. Micromagnetic simulations are employed to investigate the process of magnetization reversal in the fabricated nanowires when the magnetic materials exchange their places in the thick and thin segments...
December 11, 2017: Nanotechnology
Tae Gon Kim, Hye Jin Park, Kyoohee Woo, Sunho Jeong, Youngmin Choi, Su Yeon Lee
Conductive metallic nanomaterials applicable to low-cost and scalable methods have attracted great attention. Among these, Cu-based electrodes appear promising for flexible and stretchable electronic devices. However, Cu nanoparticle (NP)-based electrodes are inherently sensitive to oxygen and moisture, which hinder their practical applications. In this work, fabrication and application of highly conductive, robust, flexible, and oxidation-resistant Cu-Ni core-shell NP-based electrodes have been reported. Cu@Ni core-shell NPs with a tunable Ni shell thickness were synthesized by varying the Cu/Ni molar ratios in the precursor solution...
December 11, 2017: ACS Applied Materials & Interfaces
S Mahdi Hamidinejad, Raymond K M Chu, Biao Zhao, Chul B Park, Tobin Filleter
As electronic devices become increasingly miniaturized, their thermal management becomes critical. Efficient heat dissipation guarantees their optimal performance and service life. Graphene nanoplatelets (GnPs) have excellent thermal properties that show promise for use in fabricating commercial polymer nanocomposites with high thermal conductivity. Herein an industrially-viable technique for manufacturing a new class of lightweight GnP-polymer nanocomposites with high thermal conductivity is presented. Using this method, high-density-polyethylene (HDPE)-GnP nanocomposites with a microcellular structure are fabricated by melt mixing, which is followed by supercritical fluid (SCF)-treatment and injection molding foaming which adds an extra layer of design flexibility...
December 11, 2017: ACS Applied Materials & Interfaces
Pengyao Xing, Hongzhong Chen, Huijing Xiang, Yanli Zhao
Controlling the structural parameters in coassembly is crucial for the fabrication of multicomponent functional materials. Here a proof-of-concept study is presented to reveal the α-substituent effect of aromatic amino acids on their selective coassembly with bipyridine binders. With the assistance of X-ray scattering technique, it is found that individual packing in the solid state as well as bulky effect brought by α-substitution determines the occurrence of coassembly. A well-performed hydrogels based on the complexation between certain aromatic amino acids and bipyridine units are successfully constructed, providing unprecedented smart materials with light irradiation-triggered luminescence...
December 11, 2017: Advanced Materials
Shengming Yin, Wenguang Tu, Yuan Sheng, Yonghua Du, Markus Kraft, Armando Borgna, Rong Xu
In this work, a one-pot solution method for direct synthesis of interconnected ultrafine amorphous NiFe-layered double hydroxide (NiFe-LDH) (<5 nm) and nanocarbon using the molecular precursor of metal and carbon sources is presented for the first time. During the solvothermal synthesis of NiFe-LDH, the organic ligand decomposes and transforms to amorphous carbon with graphitic nanodomains by catalytic effect of Fe. The confined growth of both NiFe-LDH and carbon in one single sheet results in fully integrated amorphous NiFe-LDH/C nanohybrid, allowing the harness of the high intrinsic activity of NiFe-LDH due to (i) amorphous and distorted LDH structure, (ii) enhanced active surface area, and (iii) strong coupling between the active phase and carbon...
December 11, 2017: Advanced Materials
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