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https://www.readbyqxmd.com/read/29679815/dual-docking-robotic-surgical-staging-for-high-risk-endometrial-cancer
#1
Cécile Loaec, Anne-Sophie Bats, Charlotte Ngo, Caroline Cornou, Léa Rossi, Chérazade Bensaid, Claude Nos, Fabrice Lecuru
OBJECTIVE: The standard of care for patients with high intermediate and high risk endometrial cancer is surgical staging including total hysterectomy with bilateral salpingo-oophorectomy, and pelvic and para-aortic lymphadenectomy. Over the past decade, laparoscopic or robot-assisted minimally invasive surgery has showed many benefits in the management of endometrial cancer. Few studies have specifically assessed the use of minimally invasive surgery for staging of high risk endometrial cancer...
April 16, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29679806/an-intelligent-dual-stimuli-responsive-photosensitizer-delivery-system-with-o-2-supplying-for-efficient-photodynamic-therapy
#2
Hongjuan Zhao, Li Li, Cuixia Zheng, Yongwei Hao, Mengya Niu, Yujie Hu, Junbiao Chang, Zhenzhong Zhang, Lei Wang
The effects of photodynamic therapy (PDT) are limited by the hypoxic tumor microenvironment (TME). In this paper, a new type of biocompatible multifunctional photosensitizer delivery system was fabricated to relieve tumor hypoxia and improve the efficacy of PDT. The photosensitizer hematoporphyrin monomethyl ether (HMME) and catalase (CAT) were encapsulated in the pores of mesoporous graphitic-phase carbon nitride nanosheets (mpg-C3 N4 ). Next, hyaluronic (HA) was coated on the surface of the mpg-C3 N4 via an amide linkage to construct the tumor-targeting HAase/CAT dual activatable and mpg-C3 N4 /HMME response photosensitizer delivery system (HA@mpg-C3 N4 -HMME/CAT)...
April 10, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29679796/flame-retardant-superhydrophobic-coating-derived-from-fly-ash-on-polymeric-foam-for-efficient-oil-corrosive-water-and-emulsion-separation
#3
Jintao Wang, Hongfei Wang, Guihong Geng
Developing novel oil sorbents with both superhydrophobicity and flame resistance reveals an enticing prospect for oil/water separation. In this study, superhydrophobic foam with superior flame retardancy and sorption capability is reported through a simple one-step fabrication route in alkaline water/ethanol system containing dopamine, fly ash (FA) and dodecanethiol (DT). The introduction of FA endows the foam with excellent flame retardancy, and the as-prepared foam reveals improved flame resistance compared with original and polydopamine (PDA) coated foams, The obtained foams can quickly absorb various types of oils up to 34-47 times of their own weight, and the absorbed oils can be repeatedly recovered by a simple vacuum filtration process...
April 18, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29679672/cellulose-acetate-composite-membranes-tailored-with-exfoliated-tungsten-disulfide-nanosheets-permeation-characteristics-and-antifouling-ability
#4
S Vetrivel, M Sri Abirami Saraswathi, D Rana, K Divya, A Nagendran
An attempt has been made to demonstrate the effects of exfoliated tungsten disulfide (E-WS2 ) nanosheets on the fabrication, permeation and anti-fouling performance of cellulose acetate (CA) ultrafiltration membranes. The E-WS2 was prepared and characterized in terms of energy dispersive X-ray spectroscopy (EDXS) and X-ray diffraction spectroscopy (XRD). Pure and composite CA membranes were methodically characterized for its surface, chemical and morphological structure using FT-IR, XRD, SEM and water contact angle analysis...
April 18, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29679666/glutathione-sensitive-hollow-mesoporous-silica-nanoparticles-for-controlled-drug-delivery
#5
Seyyed Pouya Hadipour Moghaddam, Mostafa Yazdimamaghani, Hamidreza Ghandehari
Tunable glutathione (GSH)-sensitive hollow mesoporous silica nanoparticles (HMSiO2 NPs) were developed using a structural difference-based selective etching strategy. These organosilica hollow nanoparticles contained disulfide linkages (S-S) in the outer shell which were degraded by GSH. The particles were compared with their nonGSH-sensitive tetraethyl orthosilicate (TEOS) HMSiO2 counterparts in terms of their synthesis method, characterization, DOX release profile, and in vitro cytotoxicity in MCF-7 breast cancer cells...
April 18, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29679663/steric-shielding-protected-and-acidity-activated-pop-up-of-ligand-for-tumor-enhanced-photodynamic-therapy
#6
Kai Han, Zhaoyu Ma, Xinxin Dai, Jin Zhang, Heyou Han
Tumor targeted drug delivery in vivo remains a significant challenge in tumor therapy. In this article, we fabricated a steric shielding protected/tumor acidity-activated chimeric peptide for tumor targeted photodynamic therapy. This amphiphilic chimeric peptide could form spherical nanoparticles at neutrally physiological environment with the shielding of biotin molecule (tumor target ligand). When in tumor acidic microenvironment, acidity-sensitive dimethylmaleic amide was rapidly hydrolyzed, resulting in subsequent liberation of (Lys)8 and the recovery of intramolecular electrostatic interaction between (Lys)8 and (Glu)8 ...
April 18, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29679585/personalized-bioactive-nasal-supports-for-postoperative-cleft-rhinoplasty
#7
Christen J Boyer, Jennifer E Woerner, Christopher Galea, Corbin A Gatlin, Ghali E Ghali, David K Mills, Jeffery A Weisman, Jonathan S Alexander
PURPOSE: After cleft lip and palate surgical procedures, patients often need nostril supports to help the reconstructed nostrils retain their shape during healing. Many postoperative nasal stents use a one-size-fits-all approach, in which a standard rubber tube retainer is trimmed and used to support the healing nares. The purpose of this study was to examine photogrammetry and 3-dimensional (3D) printing as a fabrication tool for postoperative patient-specific nasal supports that can be loaded with bioactive agents for localized delivery...
March 28, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29679527/effects-of-a-new-chlorhexidine-varnish-on-streptococcus-mutans-biofilm-formation-in-vitro
#8
Ali Hayati, Farhud Najafi, Fahimeh Sadat Tabatabaei
BACKGROUND: Local sustained-release drug delivery systems increase the substantivity of drugs in the oral environment and subsequently enhance their therapeutic effects. This study sought to compare the effects of two commercially available varnishes and one experimental chlorhexidine (CHX) varnish on formation of Streptococcus mutans biofilm. The solubility rates of the varnishes were evaluated as well. METHODS: Standard acrylic discs were fabricated and divided into groups based on the varnish applied to the disc surfaces, namely, V-varnish, Pascal, and experimental CHX varnish...
April 21, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29679327/engineering-human-neural-tissue-by-3d-bioprinting
#9
Qi Gu, Eva Tomaskovic-Crook, Gordon G Wallace, Jeremy M Crook
Bioprinting provides an opportunity to produce three-dimensional (3D) tissues for biomedical research and translational drug discovery, toxicology, and tissue replacement. Here we describe a method for fabricating human neural tissue by 3D printing human neural stem cells with a bioink, and subsequent gelation of the bioink for cell encapsulation, support, and differentiation to functional neurons and supporting neuroglia. The bioink uniquely comprises the polysaccharides alginate, water-soluble carboxymethyl-chitosan, and agarose...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29679323/layer-by-layer-engineered-polymer-capsules-for-therapeutic-delivery
#10
Rona Chandrawati
Polymer capsules fabricated via layer-by-layer (LbL) assembly have emerged as promising carriers for therapeutic delivery. The versatile assembly technique allows an extensive choice of materials to be incorporated as constituents of the multilayers, which therefore endow capsules with specific properties and functionalities. This chapter describes protocols for fabrication of LbL-engineered poly(methacrylic acid) (PMA) capsules for applications in gene delivery, including (1) synthesis of building blocks, (2) cargo encapsulation, (3) multilayer film formation, (4) surface modification, and (5) cross-linking of multilayer films and dissolution of particle templates...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29679321/low-temperature-deposition-modeling-of-%C3%AE-tcp-scaffolds-with-controlled-bimodal-porosity
#11
E Papastavrou, P Breedon, D Fairhurst
Low-temperature deposition modeling (LDM), otherwise termed freeze-form extrusion fabrication or rapid freeze prototyping, involves dispensing an aqueous-based ceramic paste or polymeric hydrogel along predefined paths in subzero ambient temperatures, followed by freeze-drying. The solidification of the material after the deposition of each layer enables large parts to be built without the need for organic binders, which can often have cytotoxic effects. Freeze-dried parts obtained from LDM typically exhibit pores with openings that range in average between 1 and 40 μm...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29679318/engineering-citric-acid-based-porous-scaffolds-for-bone-regeneration
#12
Jacqueline J Masehi-Lano, Eun Ji Chung
Tissue engineering aims to develop scaffolds that are biocompatible and mimic the mechanical and biological properties of the target tissue as closely as possible. Here, we describe the fabrication and characterization of a biodegradable, elastomeric porous scaffold: poly(1,8-octanediol-co-citric acid) (POC) incorporated with nanoscale hydroxyapatite (HA). While this chapter focuses on the scaffold's potential for bone regeneration, POC can also be used in other tissue engineering applications requiring an elastomeric implant...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29679036/micro-thermocouple-on-nano-membrane-thermometer-for-nanoscale-measurements
#13
Armandas Balčytis, Meguya Ryu, Saulius Juodkazis, Junko Morikawa
A thermocouple of Au-Ni with only 2.5-μm-wide electrodes on a 30-nm-thick Si3 N4 membrane was fabricated by a simple low-resolution electron beam lithography and lift off procedure. The thermocouple is shown to be sensitive to heat generated by laser as well as an electron beam. Nano-thin membrane was used to reach a high spatial resolution of energy deposition and to realise a heat source of sub-1 μm diameter. This was achieved due to a limited generation of secondary electrons, which increase a lateral energy deposition...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29679013/gas-permeation-through-rubbery-polymer-nano-corrugated-membranes
#14
Giuseppe Firpo, Elena Angeli, Patrizia Guida, Roberto Lo Savio, Luca Repetto, Ugo Valbusa
The purpose of this investigation is to fabricate PDMS membranes with reliable surface roughness in order to reduce the surface resistances and to study its impact on the permeation rate. The permeance of CO2 through PDMS membranes with rough surfaces at nanoscale is studied and compared with the one of membranes with flat surfaces. At very low thickness, rough membranes have a permeance greater than that of membranes with flat surfaces. The enhancement occurs in a regime where the gas transport is sorption desorption surface rate limited, and cannot be explained by the increase in surface area due to the corrugation...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29678770/self-reported-pain-in-patients-with-schizophrenia-results-from-the-national-first-step-face-sz-cohort
#15
Guillaume Fond, Laurent Boyer, Meja Andrianarisoa, Ophelia Godin, Ewa Bulzacka, Fabrice Berna, Lore Brunel, Nathalie Coulon, Bruno Aouizerate, Delphine Capdevielle, Isabelle Chereau, Thierry D'amato, Hélène Denizot, Caroline Dubertret, Julien Dubreucq, Catherine Faget, Sylvain Leignier, Jasmina Mallet, David Misdrahi, Romain Rey, Christophe Lancon, Christine Passerieux, Aurélie Schandrin, Mathieu Urbach, Pierre Vidailhet, Marion Leboyer, Franck Schurhoff, Pierre-Michel Llorca, M Andrianarisoa, B Aouizerate, F Berna, O Blanc, L Brunel, E Bulzacka, D Capdevielle, I Chereau-Boudet, G Chesnoy-Servanin, Danion Jm, T D'Amato, A Deloge, C Delorme, H Denizot, J M Dorey, C Dubertret, J Dubreucq, C Faget, C Fluttaz, G Fond, S Fonteneau, F Gabayet, E Giraud-Baro, R M Honciuc, D Lacelle, C Lançon, H Laouamri, M Leboyer, T Le Gloahec, Y Le Strat, Llorca, J Mallet, E Metairie, D Misdrahi, I Offerlin-Meyer, C Passerieux, P Peri, S Pires, C Portalier, R Rey, C Roman, M Sebilleau, A Schandrin, F Schurhoff, A Tessier, Tronche Am, M Urbach, F Vaillant, A Vehier, P Vidailhet, E Vilà, H Yazbek, A Zinetti-Bertschy
INTRODUCTION: Little is known about perception of physical pain in schizophrenia (SZ). Some studies have suggested that patients with SZ may have an increased pain threshold, while others have suggested that patients with SZ may suffer from undetected and untreated high physical pain levels. The objectives of this study were (i) to investigate the prevalence of self-reported physical pain in stabilized SZ subjects, and (ii) to determine whether physical pain was associated with psychiatric characteristics and somatic comorbidities (iii) to determine whether antidepressants and benzodiazepine administration were associated with lower self-reported pain...
April 17, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29678676/an-asymmetric-chitosan-scaffold-for-tendon-tissue-engineering-in-vitro-and-in-vivo-evaluation-with-rat-tendon-stem-progenitor-cells
#16
Erman Chen, Ling Yang, Chenyi Ye, Wei Zhang, Jisheng Ran, Deting Xue, Zhengke Wang, Zhijun Pan, Qiaoling Hu
The poor healing capacity and typically incomplete regeneration of injured tendons has made tendon repair as a primary clinical concern. Several methods for repairing injured tendons have been developed in the last decade. Tendon regeneration using current tissue engineering techniques requires advanced biomaterials to satisfy both microstructural and mechanical criteria. In this study, a novel chitosan (CS)-based scaffold with asymmetric structure was fabricated using a self-deposition technique. The fabricated scaffolds were assessed with regard to the microstructural and mechanical demands of cell ingrowth and the prevention of peritendinous adhesion...
April 17, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29678674/the-role-of-the-micro-pattern-and-nano-topography-of-hydroxyapatite-bioceramics-on-stimulating-osteogenic-differentiation-of-mesenchymal-stem-cells
#17
Cancan Zhao, Xiaoya Wang, Long Gao, Linguo Jing, Quan Zhou, Jiang Chang
The micro/nano hybrid structure is considered to be a biomaterial characteristic to stimulate osteogenesis by mimicking the three-dimensional structure of the bone matrix. However, the mechanism of the hybrid structure induced osteogenic differentiation of stem cells is still unknown. For elucidating the mechanisms, one of the challenge is to directly fabricate micro/nano hybrid structure on bioceramics because of its brittleness. In this study, hydroxyapatite (HA) bioceramics with the micro/nano hybrid structure were firstly fabricated via a hydrothermal treatment and template method, and the effect of the different surface structures on the expression of integrins, BMP2 signaling pathways and cell-cell communication was investigated...
April 17, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29678585/fracture-load-of-metal-ceramic-monolithic-and-bi-layered-zirconia-based-posterior-fixed-dental-prostheses-after-thermo-mechanical-cycling
#18
Carlos López-Suárez, Raquel Castillo-Oyagüe, Verónica Rodríguez-Alonso, Christopher D Lynch, María-Jesús Suárez-García
OBJECTIVES: This study aims to evaluate the fracture load of differently fabricated 3-unit posterior fixed dental prostheses (FDPs) with an intermediate pontic. METHODS: Fifty sets of two stainless-steel abutments were randomly assigned to five groups (n = 10 each) depending on the material and technique used for manufacturing the FDPs: (1) Metal-ceramic (MC, control); (2) Lava Zirconia (LZ, bi-layered); (3) Lava Plus (LM, monolithic); (4) VITA In-Ceram YZ (YZ, bi-layered); and (5) IPS e-max ZirCAD (ZZ, bi-layered)...
April 17, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29678428/location-of-osteochondritis-dissecans-lesions-of-the-capitellum
#19
Christine C Johnson, Susanne Roberts, Douglas Mintz, Peter D Fabricant, Robert N Hotchkiss, Aaron Daluiski
PURPOSE: The location of capitellar osteochondritis dissecans (OCD) lesions in the sagittal plane guides the surgical approach, and lesion location in the coronal plane influences surgical management. Although most lesions have been reported to occur between 4 o'clock and 4:30 (120° to 135° anterior to the humerus), some lesions are located elsewhere in the capitellum. The primary aim was to define the region of the capitellum affected by OCD lesions using a novel clock-face localization system...
April 17, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29678192/engineering-in-vitro-stem-cell-based-vascularized-bone-models-for-drug-screening-and-predictive-toxicology
#20
REVIEW
Alessandro Pirosa, Riccardo Gottardi, Peter G Alexander, Rocky S Tuan
The production of veritable in-vitro models of bone tissue is essential to understand the biology of bone and its surrounding environment, to analyze the pathogenesis of bone diseases (e.g., osteoporosis, osteoarthritis, osteomyelitis, etc.), to develop effective therapeutic drug screening, and to test potential therapeutic strategies. Dysregulated interactions between vasculature and bone cells are often related to the aforementioned pathologies, underscoring the need for a bone model that contains engineered vasculature...
April 20, 2018: Stem Cell Research & Therapy
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