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https://www.readbyqxmd.com/read/29454301/heteroassembled-gold-nanoparticles-with-sandwich-immunoassay-lspr-chip-format-for-rapid-and-sensitive-detection-of-hepatitis-b-virus-surface-antigen-hbsag
#1
Jinwoon Kim, Seo Yeong Oh, Shruti Shukla, Seok Bok Hong, Nam Su Heo, Vivek K Bajpai, Hyang Sook Chun, Cheon-Ho Jo, Bong Gill Choi, Yun Suk Huh, Young-Kyu Han
This study aimed to develop a more sensitive method for the detection of hepatitis B surface antigen (HBsAg) using heteroassembled gold nanoparticles (AuNPs). A single layered localized surface plasmon resonance (LSPR) chip format was developed with antigen-antibody reaction-based detection symmetry using AuNPs, which detected HBsAg at 10 pg/mL. To further improve the detection limit, a modified detection format was fabricated by fixing a secondary antibody (to form a heteroassembled sandwich format) to the AuNP monolayer, which enhanced the detection sensitivity by about 100 times...
February 7, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29454278/towards-a-better-understanding-on-mercury-adsorption-by-magnetic-bio-adsorbents-with-%C3%AE-fe-2-o-3-from-pinewood-sawdust-derived-hydrochar-influence-of-atmosphere-in-heat-treatment
#2
Huabin Wang, Yong Liu, Jerosha Ifthikar, Lerong Shi, Aimal Khan, Zhulei Chen, Zhuqi Chen
Pyrolysis under protective atmosphere was regarded as an indispensable process for the preparation of biomass-based adsorbents to achieve higher surface areas. In this paper, magnetic carbon composites (MCC) that fabricated under air atmosphere showed an adsorption capacity of 167.22 mg/g in 200 ppm Hg(II), which was significantly higher than magnetic biochar (MBC, 31.80 mg/g) that fabricated under traditional nitrogen protection, and this remarkable performance of MCC was consistent in a wide range of pHs...
February 6, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29454188/modified-two-step-emulsion-solvent-evaporation-technique-for-fabricating-biodegradable-rod-shaped-particles-in-the-submicron-size-range
#3
Hanieh Safari, Reheman Adili, Michael Holinstat, Omolola Eniola-Adefeso
HYPOTHESIS: Though the emulsion solvent evaporation (ESE) technique has been previously modified to produce rod-shaped particles, it cannot generate small-sized rods for drug delivery applications due to the inherent coupling and contradicting requirements for the formation versus stretching of droplets. The separation of the droplet formation from the stretching step should enable the creation of submicron droplets that are then stretched in the second stage by manipulation of the system viscosity along with the surface-active molecule and oil-phase solvent...
February 9, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29454167/polydopamine-coated-nanocomposites-of-angelica-gigas-nakai-extract-and-their-therapeutic-potential-for-triple-negative-breast-cancer-cells
#4
Suyeong Nam, Song Yi Lee, Jung-Jin Kim, Wie-Soo Kang, In-Soo Yoon, Hyun-Jong Cho
Polydopamine (PD)-coated nanocomposites (NCs) based on the ethanol extract of Angelica gigas Nakai (AGN EtOH ext) were fabricated and evaluated for breast cancer therapy. AGN NCs were prepared using a modified emulsification-solvent evaporation method and were further incubated in dopamine solution (at pH 8.6) to be covered with the PD layer. PD-AGN NCs with a 213-nm mean diameter, narrow size distribution, and negative zeta potential values were fabricated in this study. Less negative (close to zero) zeta potential value of PD-AGN NCs than that of AGN NCs implied the existence of the PD layer in the outer surface of NCs...
February 11, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29454064/rna-based-micelles-a-novel-platform-for-chemotherapeutic-drug-loading-and-delivery
#5
Yi Shu, Hongran Yin, Mehdi Rajabi, Hui Li, Mario Vieweger, Sijin Guo, Dan Shu, Peixuan Guo
RNA can serve as powerful building blocks for bottom-up fabrication of nanostructures for biotechnological and biomedical applications. In addition to current self-assembly strategies utilizing base pairing, motif piling and tertiary interactions, we reported for the first time to build RNA based micellar nanoconstruct with a cholesterol molecule conjugated onto one helical end of a branched pRNA three-way junction (3WJ) motif. The resulting amphiphilic RNA micelles consist of a hydrophilic RNA head and a covalently linked hydrophobic lipid tail that can spontaneously assemble in aqueous solution via hydrophobic interaction...
February 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29454028/fabricating-3d-printed-orally-disintegrating-printlets-using-selective-laser-sintering
#6
Fabrizio Fina, Christine M Madla, Alvaro Goyanes, Jiaxin Zhang, Simon Gaisford, Abdul W Basit
Selective laser sintering (SLS) is a three-dimensional printing (3DP) technology employed to manufacture plastic, metallic or ceramic objects. The aim of this study was to demonstrate the feasibility of SLS to fabricating novel solid dosage forms with accelerated drug release properties, and with a view to create orally disintegrating formulations. Two polymers (hydroxypropyl methylcellulose (HPMC E5) and vinylpyrrolidone-vinyl acetate copolymer (Kollidon ® VA 64)) were separately mixed with 5% paracetamol (used as a model drug) and 3% Candurin ® gold sheen colorant; the powder mixes were subjected to SLS printing resulting in the manufacture of printlets (3DP tablets)...
February 14, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29453861/virus-like-particle-engineering-from-rational-design-to-versatile-applications
#7
REVIEW
Xuanwei Ding, Dong Liu, George Booth, Wei Gao, Yuan Lu
As mimicking natural virus structures, virus-like particles (VLPs) have evolved to become a widely accepted technology used for humans which are safe, highly efficacious and profitable. Several remarkable advantages have been achieved to revolutionize the molecule delivery for diverse applications in nanotechnology, biotechnology, and medicine. Here, we review the rational structure design, manufacturing process, functionalization strategy, and emerging applications of VLPs. The situation and challenges in the VLP engineering, the key development orientation, and future applications have been discussed...
February 17, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/29453846/fabrication-of-miniature-elastomer-lenses-with-programmable-liquid-mold-for-smartphone-microscopy-curing-polydimethylsiloxane-with-in-situ-curvature-control
#8
Bhuvaneshwari Karunakaran, Joseph Tharion, Arvind Ramrao Dhawangale, Debjani Paul, Soumyo Mukherji
Miniature lenses can transform commercial imaging systems, e.g., smartphones and webcams, into powerful, low-cost, handheld microscopes. To date, the reproducible fabrication of polymer lenses is still a challenge as they require controlled dispensing of viscous liquid. This paper reports a reproducible lens fabrication technique using liquid mold with programmable curvature and off-the-shelf materials. The lens curvature is controlled during fabrication by tuning the curvature of an interface of two immiscible liquids [polydimethylsiloxane (PDMS) and glycerol]...
February 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29453543/toxic-and-beneficial-potential-of-silver-nanoparticles-the-two-sides-of-the-same-coin
#9
Lilian Rodrigues Rosa Souza, Veronica Santana da Silva, Leonardo Pereira Franchi, Tiago Alves Jorge de Souza
Nanotechnology has allowed great changes in chemical, biological and physical properties of metals when compared to their bulk counterparts. Within this context, silver nanoparticles (AgNPs) play a major role due to their unique properties, being widely used in daily products such as fabrics, washing machines, water filters, food and medicine. However, AgNPs can enter cells inducing a "Trojan-horse" type mechanism which potentially leads to cellular autophagy, apoptosis or necrosis. On the other hand, this cytotoxicity mechanism can be optimized to develop drug nanocarriers and anticancer therapies...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29453453/a-meta-surface-antenna-array-decoupling-maad-method-for-mutual-coupling-reduction-in-a-mimo-antenna-system
#10
Ziyang Wang, Luyu Zhao, Yuanming Cai, Shufeng Zheng, Yingzeng Yin
In this paper, a method to reduce the inevitable mutual coupling between antennas in an extremely closely spaced two-element MIMO antenna array is proposed. A suspended meta-surface composed periodic square split ring resonators (SRRs) is placed above the antenna array for decoupling. The meta-surface is equivalent to a negative permeability medium, along which wave propagation is rejected. By properly designing the rejection frequency band of the SRR unit, the mutual coupling between the antenna elements in the MIMO antenna system can be significantly reduced...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453402/a-soft-lithographic-approach-to-fabricate-inas-nanowire-field-effect-transistors
#11
Sang Hwa Lee, Sung-Ho Shin, Morten Madsen, Kuniharu Takei, Junghyo Nah, Min Hyung Lee
The epitaxial layer transfer process was previously introduced to integrate high-quality and ultrathin III-V compound semiconductor layers on any substrate. However, this technique has limitation for fabrication of sub-micron nanoribbons due to the diffraction limit of photolithography. In order to overcome this limitation and scale down its width to sub-50 nm, we need either a costly short wavelength lithography system or a non-optical patterning method. In this work, high-quality III-V compound semiconductor nanowires were fabricated and integrated onto a Si/SiO 2 substrate by a soft-lithography top-down approach and an epitaxial layer transfer process, using MBE-grown ultrathin InAs as a source wafer...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453367/quantitative-analysis-of-charge-distribution-in-bi-emissive-layer-white-organic-light-emitting-diodes-with-two-fluorescent-dopants
#12
Ji Young Kim, Woo Young Kim, Kok Wai Cheah
This work seeks to establish a quantitative method which can estimate the holes and electrons ratio in the emission zones. We fabricated multilayered white organic light-emitting diodes (WOLEDs) with the device structure of ITO/NPB(80 nm)/MADN:BUBD-1(7%)(20 nm)/MADN:DCJTB(0.3%)(20 nm)/TPBi(X nm)/LiF(2 nm)/Al as a case study on the charge recombination distribution in the emissive layer. The result shows a trend in the charge recombination ratio depending on the electron transport layer thickness. We obtained an empirical relationship between electron transport layer thicknesses and emission ratio in EML...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453347/reversing-coffee-ring-effect-by-laser-induced-differential-evaporation
#13
Tony M Yen, Xin Fu, Tao Wei, Roshan U Nayak, Yuesong Shi, Yu-Hwa Lo
The coffee-ring effect, ubiquitously present in the drying process of aqueous droplets, impedes the performance of a myriad of applications involving precipitation of particle suspensions in evaporating liquids on solid surfaces, such as liquid biopsy combinational analysis, microarray fabrication, and ink-jet printing, to name a few. We invented the methodology of laser-induced differential evaporation to remove the coffee-ring effect. Without any additives to the liquid or any morphology modifications of the solid surface the liquid rests on, we have eliminated the coffee-ring effect by engineering the liquid evaporation profile with a CO 2 laser irradiating the apex of the droplets...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453328/management-of-atrial-fibrillation-in-patients-with-rheumatic-mitral-stenosis
#14
REVIEW
Bernard Iung, Antoine Leenhardt, Fabrice Extramiana
Atrial fibrillation (AF) is frequent in patients with rheumatic mitral stenosis (MS). Pressure overload leads to marked structural and electrical remodelling of left atrium. The frequency of persistent AF increases with age and paroxysmal, asymptomatic, AF seems even more frequent. The occurrence of AF worsens the haemodynamic tolerance of MS and markedly increases the risk of thromboembolic events. AF has a negative impact on the natural history of MS and on its outcome after commissurotomy. The respective indications of rhythm and rate control should be adapted to patient characteristics, particularly the consequences of MS, and take into account the high risk of recurrence of AF...
February 16, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29453104/controlling-shape-anisotropy-of-hexagonal-cds-for-highly-stable-and-efficient-photocatalytic-h-2-evolution-and-photoelectrochemical-water-splitting
#15
Yongjin Ma, Yi Liu, Yuan Bian, Anquan Zhu, Yang Yang, Jun Pan
Photocorrosion and low solar conversion efficiency hindered widely applications of CdS in photocatalytic (PC) H 2 evolution and photoelectrochemical (PEC) water splitting. Hence, this work reports the shape anisotropy of hexagonal CdS possesses highly stable and efficient PC H 2 evolution and PEC water splitting by simply mixed diethylenetriamine (DETA) and deionized water (DIW) solvothermal. Here we demonstrate that the shape of hexagonal CdS plays an important role in their PC activity. The CdS-Nanorod yields optimal 5...
February 6, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29453103/free-standing-red-phosphorous-silver-sponge-monolith-as-an-efficient-and-easily-recyclable-macroscale-photocatalyst-for-organic-pollutant-degradation-under-visible-light-irradiation
#16
Wanjun Wang, Taicheng An, Guiying Li, Yecheng Li, Jimmy C Yu, Po Keung Wong
Traditional nano-sized photocatalysts in powdery form suffer from difficulties in recyclability, and have to be immobilized before practical applications. In this study, red phosphorous/silver (red P/Ag) sponge monolith was discovered to be a new free-standing macroscale photocatalyst, which was fabricated by a one-pot hydrothermal method without using any organic surfactants or templates for the first time. The elemental red P not only functioned as a reducing agent in the formation of Ag sponge monolith during the synthesis processes, but also as the active photocatalyst in-situ immobilized onto the Ag sponge...
February 5, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29453097/self-assembled-vertically-aligned-au-nanorod-arrays-for-surface-enhanced-raman-scattering-sers-detection-of-cannabinol
#17
Sarah Milliken, Jeff Fraser, Shawn Poirier, John Hulse, Li-Lin Tay
Self-assembled multi-layered vertically aligned gold nanorod (AuNR) arrays have been fabricated by a simple preparation process that requires a balance between the particle concentration and the ionic strength of the solvent. An experimentally determined critical AuNR concentration of 2.0nM and 50mM NaCl produces well-ordered vertically aligned hexagonally close-packed AuNR arrays. We demonstrate surface treatment via UV Ozone cleaning of such samples to allow introduction of analyte molecules (benzenethiol and cannabinol) for effective surface enhanced Raman scattering detection...
January 12, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29452944/iron-engineered-mesoporous-silica-nanocatalyst-with-biodegradable-and-catalytic-framework-for-tumor-specific-therapy
#18
Liying Wang, Minfeng Huo, Yu Chen, Jianlin Shi
Inorganic mesoporous silica-based nanovehicles are highly promising for drug delivery but still suffer from the disadvantages of lacking functionality and poor biodegradability on account of the inert silica framework. Moreover, conventional cancer therapeutics typically employ toxic anticancer drugs or invasive external irradiations, which will inevitably give rise to severe adverse effects and diminished therapeutic outcome. In this work, we report on the iron engineered framework of mesoporous silica nanoparticles (MSNs) to fabricate a nanocatalyst with biodegradable and catalytic framework via a "dissolution-regeneration" strategy (designated as rFeO x -HMSN)...
February 9, 2018: Biomaterials
https://www.readbyqxmd.com/read/29452869/three-dimensional-printer-aided-casting-of-soft-custom-silicone-boluses-scsbs-for-head-and-neck-radiation-therapy
#19
Tsuicheng Chiu, Jun Tan, Mathew Brenner, Xuejun Gu, Ming Yang, Kenneth Westover, Tobin Strom, David Sher, Steve Jiang, Bo Zhao
PURPOSE: Custom tissue compensators provide dosimetric advantages for treating superficial or complex anatomy, but currently available fabrication technology is expensive or impractical for most clinical operations and yields compensators that are difficult for patients to tolerate. We aimed to develop an inexpensive, clinically feasible workflow for generating patient-specific, soft, custom silicone boluses (SCSBs) for head-and-neck (HN) radiation therapy. METHODS AND MATERIALS: We developed a method using 3-dimensional printed parts for generating SCSBs for the treatment of HN cancers...
November 11, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29452593/a-review-on-biosynthesis-of-silver-nanoparticles-and-their-biocidal-properties
#20
REVIEW
Khwaja Salahuddin Siddiqi, Azamal Husen, Rifaqat A K Rao
Use of silver and silver salts is as old as human civilization but the fabrication of silver nanoparticles (Ag NPs) has only recently been recognized. They have been specifically used in agriculture and medicine as antibacterial, antifungal and antioxidants. It has been demonstrated that Ag NPs arrest the growth and multiplication of many bacteria such as Bacillus cereus, Staphylococcus aureus, Citrobacter koseri, Salmonella typhii, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumonia, Vibrio parahaemolyticus and fungus Candida albicans by binding Ag/Ag + with the biomolecules present in the microbial cells...
February 16, 2018: Journal of Nanobiotechnology
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