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Maquins Odhiambo Sewe, Aditi Bunker, Vijendra Ingole, Thaddaeus Egondi, Daniel Oudin Åström, David M Hondula, Joacim Rocklöv, Barbara Schumann
BACKGROUND: Numerous studies have reported a strong association between temperature and mortality. Additional insights can be gained from investigating the effects of temperature on years of life lost (YLL), considering the life expectancy at the time of death. OBJECTIVES: The goal of this work was to assess the association between temperature and YLL at seven low-, middle-, and high-income sites. METHODS: We obtained meteorological and population data for at least nine years from four Health and Demographic Surveillance Sites in Kenya (western Kenya, Nairobi), Burkina Faso (Nouna), and India (Vadu), as well as data from cities in the United States (Philadelphia, Phoenix) and Sweden (Stockholm)...
January 12, 2018: Environmental Health Perspectives
Lin Deng, Likun Jin, Guangbin Dong
Herein, we describe the development of a catalytic intramolecular "cut-and-sew" transformation between cyclobutanones and alkynes to construct cyclohexenone-fused rings. The challenge arises from the need for selective coupling at the more sterically hindered proximal position, which can be addressed using an electron-rich but less bulky phosphine ligand. The control experiment and 13C-labelling study suggest that the reaction may start with cleavage of the less hindered distal C-C bond of cyclobutanones, followed by decarbonylation and CO reinsertion to enable Rh insertion at the more hindered proximal position...
January 16, 2018: Angewandte Chemie
Hamed Jalilian, Saeed Hosseini Teshnizi, Martin Röösli, Masoud Neghab
INTRODUCTION: Occupational exposure to extremely low frequency magnetic fields (ELF-MF) occurs in many occupations such as welders, electric utility workers, train drivers and sewing machine operators. There is some evidence suggesting ELF-MF exposure to be a risk factor for Alzheimer's disease (AD). The current study aims at systematically reviewing the literature and conducting a meta-analysis to evaluate the risk of AD amongst workers exposed to ELF-MF. METHODS: Bibliographic databases were searched including PubMed, EMBASE, Cochrane Library, and Web of Science in November 2017...
December 23, 2017: Neurotoxicology
Shuqu Zhang, Xia Liu, Chengbin Liu, Shenglian Luo, Longlu Wang, Tao Cai, Yunxiong Zeng, Jili Yuan, Wanyue Dong, Yong Pei, Yutang Liu
It is highly demanded to steer the charge flow in photocatalysts for efficient photocatalytic hydrogen reactions (PHRs). In this study, we developed a smart strategy to position MoS2 quantum dots (QDs) at the S vacancies on Zn facet in monolayered ZnIn2S4 (Vs-M-ZnIn2S4) to craft two-dimensional (2D) atomic-level heterostructure (MoS2QDs@Vs-M-ZnIn2S4). The electronic structure calculations indicated that the positive charge density of Zn atom around sulfur-vacancy (Vs) was more intensive than other Zn atoms...
December 20, 2017: ACS Nano
Paola de Candia, Giuseppe Matarese
Life expectancy has considerably increased over the last decades. The negative consequence of this augmented longevity has been a dramatic increase of age-related chronic neurodegenerative diseases, such as Alzheimer's, Parkinson's and multiple sclerosis. Epidemiology is telling us there exists a strong correlation between the neuronal loss characterizing these disorders and metabolic dysfunction. This review aims at presenting the evidence supporting the existence of a molecular system linking metabolism with neurodegeneration, with a specific focus on the role of two hormones with a key role in the regulatory cross talk between metabolic imbalance and the damage of nervous system: leptin and ghrelin...
December 14, 2017: Neuropharmacology
Sanae Yamauchi, Shigemitsu Iwai, Yuji Tominaga, Yosuke Kugo, Moyu Hasegawa, Futoshi Kayatani, Kunihiko Takahashi, Hisaaki Aoki, Hiroaki Kawata
We report the case of a female neonate born at 40 weeks' gestation with no known risk factors. On postnatal day 27, she was transferred to the pediatric intensive care unit and intubated for cardiorespiratory failure; she was diagnosed with group B streptococcus infective endocarditis. Mitral valve vegetations did not improve with antibiotic therapy. Mitral valve surgery was performed on postnatal day 36. A mechanical mitral valve with short-segment polytetrafluoroethylene skirt was inserted into the supra-annular position; gentian violet was applied to the sewing ring and skirt...
January 2018: Annals of Thoracic Surgery
Sarin Mathew, Melissa Bouchard, J Andreas Hoschtitzky
Repeat mitral valve replacement in patients who underwent mechanical replacement during infancy may be technically very difficult due to the small-sized annulus accommodating the prosthesis. That can lead to dense fibrosis of the small annulus onto the sewing cuff. An attempt at explanting the prosthesis carries high risk of circumflex coronary artery injury or atrioventricular junction disruption. We present a novel approach to prevent a disaster in such a difficult scenario-implanting the new prosthesis above the previous prosthetic housing after removing the prosthetic leaflets...
January 2018: Annals of Thoracic Surgery
Khojasteh Sam Dastoor, Kaiomarz P Balsara, Asif Y Gazi
INTRODUCTION: Mesh fixation in laparoscopic ventral hernia is accomplished using tacks or tacks with transfascial sutures. This is a painful operation and the pain is believed to be more due to transfascial sutures. We describe a method of transfascial suturing which fixes the mesh securely and probably causes less pain. METHOD: Up to six ports may be necessary, three on each side. A suitable-sized mesh is used and fixed with tacks all around. A 20G spinal needle is passed from the skin through one corner of the mesh...
December 11, 2017: Journal of Minimal Access Surgery
Hua-Feng Pan, Gang Wang, Jiang Liu, Xin-Xin Liu, Kun Zhao, Xiao-Fei Tang, Zhi-Wei Jiang
Robotic gastrectomy (RG) has progressed rapidly in the last decade, overcoming many obstacles in laparoscopic technology. We compared surgical performance and short-term clinical outcomes between RG and laparoscopic gastrectomy (LG). In total, 163 patients with gastric cancer were randomly treated with RG (n=102) or LG (n=61). D2 lymphadenectomy was achieved in all patients. Digestive tract reconstruction in the RG group was performed by intracorporeal hand sewing, but extracorporeal anastomosis in the LG group was performed with a 25-mm circular stapler or linear stapler...
December 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
Charushila V Gajapati, A V Pradeep, Anupama Kakhandaki, R K Praveenchandra, Sanjana Rao
Introduction: Presbyopia is an age related loss of lens accommodation resulting in inability to read and/write or to do near work. Though literacy level may be low in rural female population of South India, but household works like sewing, sorting grains and operating mobile phones must be difficult due to presbyopia. Aim: To determine the awareness of presbyopia in rural females; also, to determine the knowledge levels regarding presbyopia, spectacle coverage and reasons for not wearing spectacles...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
Aurore Trottet, Bryan Wilson, Genevieve Sew Wei Xin, Christaline George, Lemuel Casten, Claire Schmoker, Nurul Syazana Binte Modh Rawi, Moon Chew Siew, Ole Larsen, Hans S Eikaas, Karenne Tun, Guillaume Drillet
Resting strategies of planktonic organisms are important for the ecological processes of coastal waters and their impacts should be taken into consideration in management of water bodies used by multiple industries. We combined different approaches to evaluate the importance of resting stages in Singapore coastal waters. We used molecular approaches to improve the knowledge on Singapore biodiversity, we sampled and extracted cysts from sediments to evaluate the density of resting stages in Johor Strait, and we compared systematically information on Singapore planktonic biodiversity to existing published information on resting stages from these reported organisms...
December 4, 2017: Environmental Management
Arminder Jassar, Maximilian Kreibich, Julia Morlock, Stoyan Kondov, Johannes Scheumann, Fabian A Kari, Bartosz Rylski, Matthias Siepe, Alexander Jonaszik, Cornelius Keyl, Frank Humburger, Friedhelm Beyersdorf, Martin Czerny
BACKGROUND: To report a new technique for diameter correction in patients after thoracic endovascular aortic repair (TEVAR) with large stent-grafts using the Vascutek Siena 4-branch collared prosthesis (Vascutek Terumo, Inchinnan, Scotland, UK) in patients undergoing thoracoabdominal (TA) aortic replacement. METHODS: Within a 24-month period, 39 patients underwent TA replacement at our center. Of these, 6 patients had undergone previous TEVAR with large stent-grafts (42 to 48 mm diameter)...
December 1, 2017: Annals of Thoracic Surgery
Saad Jan, Chunyu Li, Sisi Liu, Xiangyang Liu, Fuxing Zhu, Muhammad Hafeez, Mo Wang
The beet armyworm, Spodoptera exigua (Hubner), is one of the major crop pests and is a target for current pest control approaches using insecticides. S. exigua melanic mutants (SEM) spontaneously occurred in the S. exigua wild type (SEW) strain and have been maintained under laboratory conditions on an artificial diet. Scanning electron microscopy showed that the inner cuticle of the SEM had a denser and less orderly structure. We investigated the cuticle protein genes using RNA-seq at three different developmental stages of both SEM and SEW...
November 28, 2017: Microbial Pathogenesis
Yuyan Weng, Zhiyun Li, Lun Peng, Weidong Zhang, Gaojian Chen
Quantum dots (QDs) are promising materials in nanophotonics, biological imaging, and even quantum computing. Precise positioning and patterning of QDs is a prerequisite for realizing their actual applications. Contrary to the traditional two discrete steps of fabricating and positioning QDs, herein, a novel sugar-electron-beam writing (SEW) method is reported for producing QDs via electron-beam lithography (EBL) that uses a carefully chosen synthetic resist, poly(2-(methacrylamido)glucopyranose) (PMAG). Carbon QDs (CQDs) could be fabricated in situ through electron beam exposure, and the nanoscale position and luminescence intensity of the produced CQDs could be precisely controlled without the assistance of any other fluorescent matter...
November 30, 2017: Nanoscale
Handy Darmawan
Penetrating foreign bodies in the heart is rare and may lead to life-threatening complications. Early diagnosis and removal are crucial for these rare cases. We report a case of accidental penetrating sewing needle in the right ventricle. The needle was successfully removed without open heart surgery and cardiopulmonary bypass (CPB), after accurate localization using transthoracic echocardiography (TTE).
November 24, 2017: Annals of Thoracic and Cardiovascular Surgery
Joshua K Wong, Amber L Melvin, Juan A Siordia, Devang J Joshi, Jude S Sauer, Peter A Knight
PURPOSE: Annular suture placement during minimally invasive right anterior thoracotomy aortic valve replacements (MI-AVR) can be challenging. We present the early clinical experience with novel automated suturing technology that may reduce the technical difficulty of this operation. DESCRIPTION: The technology presented involves an automated articulating suturing device that simultaneously drives dual-curved needles through the aortic annulus to place a pledgeted horizontal mattress suture remotely; a second device with 2 straight needles places suture through the sewing cuff of a prosthetic heart valve...
November 23, 2017: Annals of Thoracic Surgery
Zi-Qiang Rong, Hee Nam Lim, Guangbin Dong
A rhodium-catalyzed intramolecular acetyl-group transfer has been achieved through a "cut and sew" process. The challenge arises from existence of different competitive pathways. Preliminary success has been achieved with unstrained enones that contain a biaryl linker. The use of electron-rich N-heterocycilc carbene (NHC) ligand is effective to inhibit undesired β-H elimination. Various 9,10-dihydrophenanthrene derivatives can be prepared with excellent functional group compatibility. The 13C-labelling study suggests that the reaction begins with cleavage of the unstrained C-C bond, followed by migratory insertion and reductive elimination...
November 24, 2017: Angewandte Chemie
Parajuli Anuj, Yong Sik Yoon, Chang Sik Yu, Jong Lyul Lee, Chan Wook Kim, In Ja Park, Seok-Byung Lim, Jin Cheon Kim
Purpose: In this study, we evaluated the role of various anastomoses in surgical recurrence for patients with Crohn disease (CD). Methods: We analyzed data retrospectively from consecutive laparotomy cases involving complicated CD between 1991 and 2008. Clinical data were compared in terms of reoperation-free survival (RFS) according to the types of anastomoses, the materials used for the anastomoses, and the operating surgeon. Results: Of 233 patients with entero-enteric or entero-colic anastomoses, 199 (85%), 11 (5%), and 23 (10%) experienced side-to-side (SS), side-to-end (SE), and end-to-end (EE) anastomoses, respectively...
October 2017: Annals of Coloproctology
Muhammad A Rana, Peter Gloviczki, Audra A Duncan, Manju Kalra, Kevin L Greason, Gustavo S Oderich, Stephen S Cha, Thomas C Bower
OBJECTIVE: The objective of this study was to compare outcomes after repair of type III and type IV thoracoabdominal aortic aneurysms (TAAAs) by three different open surgical techniques at a tertiary care institution. METHODS: Consecutive patients who underwent elective repair of type III and type IV TAAAs at our institution between 1999 and 2011 were retrospectively reviewed. Patients were divided into three groups according to surgical technique: clamp and sew (CS), left-sided heart bypass (LHB), and visceral branching (VB) followed by aortic reconstruction...
November 6, 2017: Journal of Vascular Surgery
Sabine Sewing, Adrian B Roth, Michael Winter, Andreas Dieckmann, Cristina Bertinetti-Lapatki, Yann Tessier, Claudia McGinnis, Sylwia Huber, Erich Koller, Corinne Ploix, John C Reed, Thomas Singer, Andreas Rothfuss
Single-stranded oligonucleotides (ON) comprise a promising therapeutic platform that enables selective modulation of currently undruggable targets. The development of novel ON drug candidates has demonstrated excellent efficacy, but in certain cases also some safety liabilities were reported. Among them are events of thrombocytopenia, which have recently been evident in late stage trials with ON drugs. The underlying mechanisms are poorly understood and the risk for ON candidates causing such events cannot be sufficiently assessed pre-clinically...
2017: PloS One
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