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https://www.readbyqxmd.com/read/29122422/comparison-of-open-surgical-techniques-for-repair-of-types-iii-and-iv-thoracoabdominal-aortic-aneurysms
#1
Muhammad A Rana, Peter Gloviczki, Audra A Duncan, Manju Kalra, Kevin L Greason, Gustavo S Oderich, Stephen S Cha, Thomas C Bower
OBJECTIVE: The objective of this study was to compare outcomes after repair of type III and type IV thoracoabdominal aortic aneurysms (TAAAs) by three different open surgical techniques at a tertiary care institution. METHODS: Consecutive patients who underwent elective repair of type III and type IV TAAAs at our institution between 1999 and 2011 were retrospectively reviewed. Patients were divided into three groups according to surgical technique: clamp and sew (CS), left-sided heart bypass (LHB), and visceral branching (VB) followed by aortic reconstruction...
November 6, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29107969/assessing-single-stranded-oligonucleotide-drug-induced-effects-in-vitro-reveals-key-risk-factors-for-thrombocytopenia
#2
Sabine Sewing, Adrian B Roth, Michael Winter, Andreas Dieckmann, Cristina Bertinetti-Lapatki, Yann Tessier, Claudia McGinnis, Sylwia Huber, Erich Koller, Corinne Ploix, John C Reed, Thomas Singer, Andreas Rothfuss
Single-stranded oligonucleotides (ON) comprise a promising therapeutic platform that enables selective modulation of currently undruggable targets. The development of novel ON drug candidates has demonstrated excellent efficacy, but in certain cases also some safety liabilities were reported. Among them are events of thrombocytopenia, which have recently been evident in late stage trials with ON drugs. The underlying mechanisms are poorly understood and the risk for ON candidates causing such events cannot be sufficiently assessed pre-clinically...
2017: PloS One
https://www.readbyqxmd.com/read/29105631/phytoformulation-of-sassurea-lappa-plant-extract-a-single-blind-noninvasive-and-split-face-study-of-cream-on-various-skin-parameters
#3
Qazi Adnan, Naveed Akhtar, Barkat Ali Khan
Saussurea lappa (SL) has been reported for its antioxidant and anti-ageing properties. Due to this reason it can be incorporated in a stable phytoformulations for cosmetic use. The objective of the study was to evaluate the anti-aging potential of cosmetic o/w emulsion containing the botanical extract of SL. An emulsion (o/w) was prepared using TEGO® Care 450 (Polyglceryl-3-Methyl Glucose Distearate) emulsifier and final emulsion was loaded with 4 % extract of SL in aqueous phase. This emulsion evaluated for its antioxidant and anti-ageing properties on healthy human subjects using a non-invasive technique called surface evaluation of living skin (SELS)...
September 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29102994/excess-burden-of-non-communicable-disease-years-of-life-lost-from-heat-in-rural-burkina-faso-a-time-series-analysis-of-the-years-2000-2010
#4
Aditi Bunker, Maquins Odhiambo Sewe, Ali Sié, Joacim Rocklöv, Rainer Sauerborn
OBJECTIVES: Investigate the association of heat exposure on years of life lost (YLL) from non-communicable diseases (NCD) in Nouna, Burkina Faso, between 2000 and 2010. DESIGN: Daily time series regression analysis using distributed lag non-linear models, assuming a quasi-Poisson distribution of YLL. SETTING: Nouna Health and Demographic Surveillance System, Kossi Province, Rural Burkina Faso. PARTICIPANTS: 18 367 NCD-YLL corresponding to 790 NCD deaths recorded in the Nouna Health and Demographic Surveillance Site register over 11 years...
November 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/29096948/the-lancet-countdown-on-health-and-climate-change-from-25-years-of-inaction-to-a-global-transformation-for-public-health
#5
REVIEW
Nick Watts, Markus Amann, Sonja Ayeb-Karlsson, Kristine Belesova, Timothy Bouley, Maxwell Boykoff, Peter Byass, Wenjia Cai, Diarmid Campbell-Lendrum, Jonathan Chambers, Peter M Cox, Meaghan Daly, Niheer Dasandi, Michael Davies, Michael Depledge, Anneliese Depoux, Paula Dominguez-Salas, Paul Drummond, Paul Ekins, Antoine Flahault, Howard Frumkin, Lucien Georgeson, Mostafa Ghanei, Delia Grace, Hilary Graham, Rébecca Grojsman, Andy Haines, Ian Hamilton, Stella Hartinger, Anne Johnson, Ilan Kelman, Gregor Kiesewetter, Dominic Kniveton, Lu Liang, Melissa Lott, Robert Lowe, Georgina Mace, Maquins Odhiambo Sewe, Mark Maslin, Slava Mikhaylov, James Milner, Ali Mohammad Latifi, Maziar Moradi-Lakeh, Karyn Morrissey, Kris Murray, Tara Neville, Maria Nilsson, Tadj Oreszczyn, Fereidoon Owfi, David Pencheon, Steve Pye, Mahnaz Rabbaniha, Elizabeth Robinson, Joacim Rocklöv, Stefanie Schütte, Joy Shumake-Guillemot, Rebecca Steinbach, Meisam Tabatabaei, Nicola Wheeler, Paul Wilkinson, Peng Gong, Hugh Montgomery, Anthony Costello
No abstract text is available yet for this article.
October 30, 2017: Lancet
https://www.readbyqxmd.com/read/29078575/video-assisted-thoracoscopic-bronchoplasty
#6
Thirugnanam Agasthian
Video-assisted thoracoscopic surgery (VATS) bronchoplasty is an advanced VATS technique requiring experience in endoscopic sewing, tying and suturing techniques reserved for cancers arising from central airways. There are three main types of bronchoplasty depending on the extent of cancer involvement of the bronchus. In this paper the author describes his experience with different types of bronchoplasty with case and video illustrations.
2017: J Vis Surg
https://www.readbyqxmd.com/read/29062586/-cut-and-sew-transformations-via-transition-metal-catalyzed-carbon-carbon-bond-activation
#7
Peng-Hao Chen, Brent A Billett, Tatsuhiro Tsukamoto, Guangbin Dong
The transition metal-catalyzed "cut and sew" transformation has recently emerged as a useful strategy for preparing complex molecular structures. After oxidative addition of a transition metal into a carbon-carbon bond, the resulting two carbon termini can be both functionalized in one step via the following migratory insertion and reductive elimination with unsaturated units, such as alkenes, alkynes, allenes, CO and polar multiple bonds. Three- or four-membered rings are often employed as reaction partners due to their high ring strains...
February 3, 2017: ACS Catalysis
https://www.readbyqxmd.com/read/29036438/a-selective-sphingosine-1-phosphate-receptor-1-agonist-sew-2871-aggravates-gastric-cancer-by-recruiting-myeloid-derived-suppressor-cells
#8
Yujing Zhou, Feng Guo
The immune status of tumor microenvironment in gastric cancer is poorly understood, which limits the development of novel strategies in this field. Sphingosine-1-phosphate (S1P) acts as an immune modulator, but the role of S1P in gastric cancer is elusive. Here, we aim to investigate S1P receptor 1 (S1P1)-mediated effect of S1P in gastric cancer. We generated a xenograft mouse model and used SEW-2871, a S1P1 specific agonist to activate S1P1 signaling. Tumor-infiltrating lymphocytes (TILs) were isolated and analyzed using flow cytometry...
October 3, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/29029355/over-sewing-of-staple-line-in-laparoscopic-sleeve-gastrectomy-initial-experience-of-a-comparative-study
#9
Giorgio Lisi, Roberto Rossini, Irene Gentile, Giacomo Ruffo
INTRODUCTION: The main drawback of laparoscopic sleeve gastrectomy (LSG) is the severity of postoperative complications. Staple line reinforcement (SLR) is strongly advocated. Recently, over-sewing has been proposed as a cost-effective and helpful method for reinforcing the staple line. The purpose of this study was to report our initial experience with LSG comparing over-sewing over the entire staple line with the upper-third staple line. MATERIALS AND METHODS: All obese patients seen at Negrar Sacro Cuore, Don Calabria Hospital were entered into our prospective database and were retrospectively evaluated...
October 12, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29019459/self-inflicated-cardiac-injury-by-multipl-sewing-needles
#10
Özgür Altınbaş, Sümeyye Fatma Özer, Abdurrahman Şeramet, Ömer Tanyeli, Niyazi Görmüş
No abstract text is available yet for this article.
October 11, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/29016464/perceptions-of-diabetes-self-care-management-among-older-singaporeans-with-type-2-diabetes-a-qualitative-study
#11
Cherry Chay Lee Tan, Karis Kin Fong Cheng, Chee Fang Sum, Jasmine Sew Hong Shew, Eleanor Holydard, Wenru Wang
BACKGROUND: Given the global shift in aging populations and the associated increasing prevalence of diabetes, it is critical to explore new approaches in diabetic self-care management. In Singapore, what has been overlooked to date is an in-depth, contextually based examination of the needs, expectations, and barriers faced in self-care management by older adults with Type 2 diabetes. PURPOSE: This study aimed to explore the experiences of older Singaporeans with Type 2 diabetes in diabetes self-care management to understand their perceived needs, expectations, and barriers associated with their diabetes self-care management...
October 10, 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/28972941/flexible-and-stretchable-microbial-fuel-cells-with-modified-conductive-and-hydrophilic-textile
#12
Sumiao Pang, Yang Gao, Seokheun Choi
We built a flexible, stretchable microbial fuel cell (MFC) by laminating two functional components: a bioanode textile with a conductive and hydrophilic polymer coating and a solid-state cathode textile loaded with silver oxide. The textile MFC used Pseudomonas aeruginosa PAO1 as a biocatalyst to generate the maximum power and current density of 1.0µW/cm(2) and 6.3µA/cm(2), respectively, which are comparable with or even higher than other flexible MFCs such as paper-based devices (~ a few µW/cm(2)). Additionally, the textile MFC generated consistent power even with repeated 70 cycles of 50% stretching...
September 28, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28970956/a-novel-roux-en-y-reconstruction-involving-the-use-of-two-circular-staplers-after-distal-subtotal-gastrectomy-for-gastric-cancer
#13
Hoon Hur, Chang Wook Ahn, Cheul Su Byun, Ho Jung Shin, Young Bae Kim, Sang-Yong Son, Sang-Uk Han
PURPOSE: Although Roux-en-Y (R-Y) reconstruction after distal gastrectomy has several advantages, such as prevention of bile reflux into the remnant stomach, it is rarely used because of the technical difficulty. This prospective randomized clinical trial aimed to show the efficacy of a novel method of R-Y reconstruction involving the use of 2 circular staplers by comparing this novel method to Billroth-I (B-I) reconstruction. MATERIALS AND METHODS: A total of 118 patients were randomly allocated into the R-Y (59 patients) and B-I reconstruction (59 patients) groups...
September 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28965725/a-prospective-randomized-trial-of-the-cut-and-sew-maze-procedure-in-patients-undergoing-surgery-for-rheumatic-mitral-valve-disease
#14
Huishan Wang, Jinsong Han, Zengwei Wang, Zongtao Yin, Zhigang Liu, Yan Jin, Hongguang Han
OBJECTIVE: To evaluate the safety and efficacy of the addition of the cut-and-sew Maze III procedure (CSM) for mitral valve replacement (MVR) in patients with atrial fibrillation (AF) associated with rheumatic mitral valve disease (RMVD). METHODS: A total of 130 patients with persistent or long-standing persistent AF associated with RMVD were assigned at random to either the CSM plus MVR (Maze III) group or MVR alone (non-Maze) group. The primary endpoint was a composite of freedom from stroke and death at 1 year...
September 5, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28951709/fabrication-of-tamarindus-indica-seeds-extract-loaded-cream-for-photo-aged-skin-visioscan-%C3%A2-studies
#15
Muhammad Khurram Waqas, Barkat Ali Khan, Naveed Akhtar, Farzana Chowdhry, Haroon Khan, Sattar Bakhsh, Shahzeb Khan, Akhtar Rasul
INTRODUCTION: Intracellular and extracellular oxidative stress triggered by free radicals promotes skin aging, which is designated by atypical pigmentation and wrinkles. The consumption of antioxidants is an efficacious measure to avert symptoms involved in skin aging. AIM: The current research was commenced to explore the anti-aging potential of antioxidants present in Tamarindus indica seeds extract. MATERIAL AND METHODS: Tamarindus indica seeds extract was obtained by concentrating the ethanolic extract of seeds...
August 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28950296/a-modified-explant-technique-of-heartware-ventricular-assist-device-for-bridge-to-recovery
#16
Yasuhiro Shudo, Chun W Choi, Y Joseph Woo, Richard-Tien V Ha
The HeartWare left ventricular assist device is a miniaturized, continuous centrifugal-flow pump. The implantation technique is well described and relatively standardized across different institutions. However, there still exists a technical concern about handling the inflow cannula at the time of device explant. Specifically, the removal of the sewing ring and plicating the apical defect en masse may distort the geometry of the left ventricle and impart myocardial dysfunction. Additionally, a prefabricated repair mechanism by the manufacturer is not readily available in all countries (i...
July 27, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28947218/late-peroneal-neuropathy-after-open-surgical-treatment-of-popliteal-artery-aneurysm
#17
Anne Lejay, Salomé Kuntz, Anne-Florence Rouby, Yannick Georg, Fabien Thaveau, Bernard Geny, Nabil Chakfé
We report the case of a 71-year-old man complaining of swollen left limb and progressively worsening pain. He underwent surgery 12 years ago for popliteal artery aneurysm with proximal and distal ligation and venous bypass grafting. The patient was diagnosed as having left peroneal neuropathy caused by a 10.5 cm expanded aneurysmal sac compressing the peroneal nerve in the popliteal fossa. The patient underwent open repair with opening of the aneurysmal sac, removal of the thrombus, and sewing of the left genicular artery responsible for back-bleeding...
September 23, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28947132/culture-methods-of-diffuse-intrinsic-pontine-glioma-cells-determine-response-to-targeted-therapies
#18
Michaël H Meel, A Charlotte P Sewing, Piotr Waranecki, Dennis S Metselaar, Laurine E Wedekind, Jan Koster, Dannis G van Vuurden, Gertjan J L Kaspers, Esther Hulleman
Diffuse intrinsic pontine glioma (DIPG) is an aggressive type of brainstem cancer occurring mainly in children, for which there currently is no effective therapy. Current efforts to develop novel therapeutics for this tumor make use of primary cultures of DIPG cells, maintained either as adherent monolayer in serum containing medium, or as neurospheres in serum-free medium. In this manuscript, we demonstrate that the response of DIPG cells to targeted therapies in vitro is mainly determined by the culture conditions...
November 15, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28944583/venous-anastomosis-using-a-non-penetrating-vascular-closure-system-in-orthotopic-liver-transplantation
#19
Yuan Wang, Zhao Xin, Bing Pan, Shao-Cheng Lv, Xing-Mao Zhang, Zhi-Hua Zhang, Li-Xin Li, Xian-Liang Li, Qiang He
BACKGROUND: A non-penetrating vessel closure system (VCS-AnastoClip(®) ) may facilitate vascular anastomosis. The purpose of this study is to explore the utilization of a non-penetrating VCS in orthotopic liver transplantation (OLT). METHODS: From January 2015 to February 2017, patients who underwent OLT were divided into two groups, ie, those who underwent non-penetrating VCS application for inferior vena cava (IVC) and portal vein (PV) reconstructions and those who underwent hand sewing for these purposes...
September 25, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28939774/bacterial-dnab-helicase-interacts-with-the-excluded-strand-to-regulate-unwinding
#20
Sean M Carney, Shivasankari Gomathinayagam, Sanford H Leuba, Michael A Trakselis
Replicative hexameric helicases are thought to unwind duplex DNA by steric exclusion (SE), where one DNA strand is encircled by the hexamer and the other is excluded from the central channel. However, interactions with the excluded strand on the exterior surface of hexameric helicases have also been shown to be important for DNA unwinding, giving rise to the steric exclusion and wrapping (SEW) model. For example, the archaeal SsoMCM helicase has been shown to unwind DNA via a SEW mode to enhance unwinding efficiency...
September 22, 2017: Journal of Biological Chemistry
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