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https://www.readbyqxmd.com/read/29739682/multispecies-probiotics-combination-prevents-ovalbumin-induced-airway-hyperreactivity-in-mice
#1
Jui-Cheng Chen, Cheng-Chih Tsai, Chang-Chi Hsieh, Alice Lan, Chun-Chih Huang, Sew-Fen Leu
BACKGROUND: Probiotics could be beneficial to health and some of them have shown to modulate immune responses. AIM: The aim of this study is to investigate if the probiotic strains including Lactobacillus and Pediococcus strains are able to alleviate allergic reactions in an ovalbumin-induced airway allergy model. METHODS: Lactobacillus multi-species preparation (LMP) was gavaged to BALB/c for total six weeks and BALB/c was challenged with ovalbumin in the last two weeks...
May 5, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29727447/early-warning-and-response-system-ewars-for-dengue-outbreaks-recent-advancements-towards-widespread-applications-in-critical-settings
#2
Laith Hussain-Alkhateeb, Axel Kroeger, Piero Olliaro, Joacim Rocklöv, Maquins Odhiambo Sewe, Gustavo Tejeda, David Benitez, Balvinder Gill, S Lokman Hakim, Roberta Gomes Carvalho, Leigh Bowman, Max Petzold
BACKGROUND: Dengue outbreaks are increasing in frequency over space and time, affecting people's health and burdening resource-constrained health systems. The ability to detect early emerging outbreaks is key to mounting an effective response. The early warning and response system (EWARS) is a toolkit that provides countries with early-warning systems for efficient and cost-effective local responses. EWARS uses outbreak and alarm indicators to derive prediction models that can be used prospectively to predict a forthcoming dengue outbreak at district level...
2018: PloS One
https://www.readbyqxmd.com/read/29723845/influence-of-sulfur-dioxide-ethanol-water-pretreatment-on-the-physicochemical-properties-and-enzymatic-digestibility-of-bamboo-residues
#3
Caoxing Huang, Junmei Ma, Chen Liang, Xi Li, Qiang Yong
SO2 -ethanol-water (SEW) is a promising pretreatment for improving enzymatic digestibility of biomass through simultaneously removing hemicellulose and lignin. In this work, SEW pretreatment was performed at different cooking times (10 min-60 min) and different SO2 concentrations (0.5%-2%) to produce pretreated bamboo residues for enzymatic hydrolysis. Meanwhile, physicochemical features of the residual cellulose and lignin were analyzed to better understand how SEW improves enzymatic digestibility. Under optimized SEW pretreatment condition (1% SO2 concentration, 150 °C, 60 min), 81...
April 30, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29671592/inactivation-mechanisms-of-human-and-animal-rotaviruses-by-solar-uva-and-visible-light
#4
Elbashir Araud, Joanna L Shisler, Thanh H Nguyen
Two rotavirus (RV) strains (sialidase-resistant Wa and sialidase-sensitive OSU) were irradiated with simulated solar UVA and visible light in sensitizer-free phosphate buffered solution (lacking exogenous reactive oxygen species (ROS)) or secondary effluent wastewater (producing ROS). Although light attenuated for up to 15% through the secondary effluent wastewater (SEW), the inactivation efficacies increased by 0.7 log10 for Wa and 2 log10 for OSU compared to those in sensitizer-free phosphate buffered solution (PBS) after 4 hrs of irradiation...
April 19, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29659276/protocols-for-requirement-driven-protein-design-in-the-rosetta-modeling-program
#5
Sharon Guffy, Frank Teets, Minnie Langlois, Brian Kuhlman
We have developed a set of protocols in the molecular modeling program Rosetta for performing requirement-driven protein design. First, the user specifies a set of structural features that they wish to be present in the designed protein. These requirements can be general, e.g. create a protein with five helices, or they can be very specific and require the correct placement of a set of amino acids to bind a ligand. Next, a large set of protein models are generated that satisfy the design requirements. The models are built using a method we recently introduced into Rosetta, called SEWING, that rapidly assembles novel protein backbones by combining pieces of naturally occurring proteins...
April 16, 2018: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29658681/laparoscopic-radical-prostatectomy-in-2018-20-years-of-worldwide-experiences-experimentations-researches-and-refinements
#6
Aldo Brassetti, Renaud Bollens
INTRODUCTION: After the first feasibility report in 1997, a growing interest has risen in the urologic community for laparoscopic radical prostatectomy (LRP) and several authors have contributed to the evolution of the technique. We attempt a review of the available evidences and provide a broad framework of different technical refinements considering their impact on pentafecta. EVIDENCE ACQUISITION: The PubMed/Medline database was searched. Duplicates and "Expert opinion" papers were removed...
April 13, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29626155/protein-coalation-and-antioxidant-function-of-coenzyme-a-in-prokaryotic-cells
#7
Yugo Tsuchiya, Alexander Zhyvoloup, Jovana Bakovic, Naam Thomas, Bess Yi Kun Yu, Sayoni Das, Christine Orengo, Clare Newell, John Ward, Giorgio Saladino, Federico Comitani, Francesco L Gervasio, Oksana M Malanchuk, Antonina I Khoruzhenko, Valeriy Filonenko, Sew Yeu Peak-Chew, Mark Skehel, Ivan Gout
In all living organisms, Coenzyme A (CoA) is an essential cofactor with a unique design allowing it to function as an acyl group carrier and a carbonyl-activating group in diverse biochemical reactions. It is synthesized in a highly conserved process in prokaryotes and eukaryotes that requires pantothenic acid (vitamin B5), cysteine and ATP. CoA and its thioester derivatives are involved in major metabolic pathways, allosteric interactions and the regulation of gene expression. A novel unconventional function of CoA in redox regulation has been recently discovered in mammalian cells and termed protein CoAlation...
April 6, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29606567/open-repair-of-descending-and-thoracoabdominal-aortic-aneurysms-in-octogenarians
#8
Leonard N Girardi, Christopher Lau, Lucas B Ohmes, Benjamin C Degner, Jeremy R Leonard, Ahmed Abouarab, Antonino Di Franco, Erin M Iannacone, Monica Munjal, Mario Gaudino
OBJECTIVE: Despite improved outcomes for open repair of descending thoracic aneurysm (DTA) and thoracoabdominal aortic aneurysm (TAAA), these operations remain challenging in octogenarians. Patients unsuitable for thoracic endovascular aortic repair require open surgery to avoid catastrophic rupture. We analyzed our results for DTA/TAAA repair in these elderly patients. METHODS: Our institutional aortic database was queried to identify those ≥80 years old and those <80 years old undergoing open DTA/TAAA repair...
March 29, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29593832/bioprosthetic-valve-fracture-during-valve-in-valve-tavr-bench-to-bedside
#9
John T Saxon, Keith B Allen, David J Cohen, Adnan K Chhatriwalla
Valve-in-valve (VIV) transcatheter aortic valve replacement (TAVR) has been established as a safe and effective means of treating failed surgical bioprosthetic valves (BPVs) in patients at high risk for complications related to reoperation. Patients who undergo VIV TAVR are at risk of patient-prosthesis mismatch, as the transcatheter heart valve (THV) is implanted within the ring of the existing BPV, limiting full expansion and reducing the maximum achievable effective orifice area of the THV. Importantly, patient-prosthesis mismatch and high residual transvalvular gradients are associated with reduced survival following VIV TAVR...
January 2018: Interventional Cardiology
https://www.readbyqxmd.com/read/29590383/the-cox-maze-iv-procedure-in-its-second-decade-still-the-gold-standard
#10
Chawannuch Ruaengsri, Matthew R Schill, Ali J Khiabani, Richard B Schuessler, Spencer J Melby, Ralph J Damiano
Atrial fibrillation (AF) is the most common cardiac arrhythmia and the treatment options include medical treatment and catheter-based or surgical interventions. AF is a major cause of stroke, and its prevalence is increasing. The surgical treatment of AF has been revolutionized over the past 2 decades through surgical innovation and improvements in endoscopic imaging, ablation technology and surgical instrumentation. The Cox-maze (CM) procedure, which was developed by James Cox and introduced clinically in 1987, is a procedure in which multiple incisions are created in both the left and the right atria to eliminate AF while allowing the sinus impulse to reach the atrioventricular node...
April 1, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29569671/spontaneous-rolling-up-and-assembly-of-graphene-designed-by-using-defects
#11
Ying Wang, Zishun Liu
The inverse Stone-Wales defect is a typical defect in graphene, which causes local bumps and local deformation in graphene sheets. Our molecular dynamics simulations show that the spontaneous rolling up of graphene sheets can be induced by orderly distributed inverse Stone-Wales defect bumps, when defective graphene is cut into small strips. This spontaneous process is mainly dominated by the defect density and tailored graphene size. When the tailored length is longer than the upper threshold length, graphene sews up as a curly one-dimensional structure: heart-shaped nanotube...
March 23, 2018: Nanoscale
https://www.readbyqxmd.com/read/29558183/sewing-up-solutions
#12
Chris Hayhurst
No abstract text is available yet for this article.
March 2018: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/29555938/author-correction-using-remote-sensing-environmental-data-to-forecast-malaria-incidence-at-a-rural-district-hospital-in-western-kenya
#13
Maquins Odhiambo Sewe, Yesim Tozan, Clas Ahlm, Joacim Rocklöv
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
March 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29530775/construction-of-an-apical-plug-for-explantation-of-heartware-hvad-left-ventricular-assist-device
#14
Shawn M Shah, Nicholas R Teman, Eileen Dearth, Leora T Yarboro, John A Kern
Utilization of a left ventricular assist device (LVAD) as a bridge to myocardial recovery is an established therapy for acute systolic heart failure. However, device removal can present a technical challenge with no clear consensus on preferred method. In this case report, we describe a complex patient who underwent successful explantation of an LVAD using an intraoperatively constructed apical plug. This method utilizes inexpensive and easily accessible materials, minimizes ventricular distortion during device removal, and preserves the ventricular sewing ring for future reimplantation...
March 9, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29528045/the-network-for-analysing-longitudinal-population-based-hiv-aids-data-on-africa-alpha-data-on-mortality-by-hiv-status-and-stage-on-the-hiv-care-continuum-among-the-general-population-in-seven-longitudinal-studies-between-1989-and-2014
#15
Emma Slaymaker, Estelle McLean, Alison Wringe, Clara Calvert, Milly Marston, Georges Reniers, Chodziwadziwa Whiteson Kabudula, Amelia Crampin, Alison Price, Denna Michael, Mark Urassa, Daniel Kwaro, Maquins Sewe, Jeffrey W Eaton, Rebecca Rhead, Jessica Nakiyingi-Miiro, Tom Lutalo, Dorean Nabukalu, Kobus Herbst, Victoria Hosegood, Basia Zaba
Timely progression of people living with HIV (PLHIV) from the point of infection through the pathway from diagnosis to treatment is important in ensuring effective care and treatment of HIV and preventing HIV-related deaths and onwards transmission of infection.  Reliable, population-based estimates of new infections are difficult to obtain for the generalised epidemics in sub-Saharan Africa.  Mortality data indicate disease burden and, if disaggregated along the continuum from diagnosis to treatment, can also reflect the coverage and quality of different HIV services...
November 6, 2017: Gates open research
https://www.readbyqxmd.com/read/29521501/melding-vapor-phase-organic-chemistry-and-textile-manufacturing-to-produce-wearable-electronics
#16
Trisha L Andrew, Lushuai Zhang, Nongyi Cheng, Morgan Baima, Jae Joon Kim, Linden Allison, Steven Hoxie
Body-mountable electronics and electronically active garments are the future of portable, interactive devices. However, wearable devices and electronic garments are demanding technology platforms because of the large, varied mechanical stresses to which they are routinely subjected, which can easily abrade or damage microelectronic components and electronic interconnects. Furthermore, aesthetics and tactile perception (or feel) can make or break a nascent wearable technology, irrespective of device metrics...
April 17, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29483479/-future-aspects-of-bio-bentall-procedure
#17
Masato Mutsuga, Akihiko Usui
The Bentall procedures using biological valved conduit is expanding owing to the increasing incidence of aortic valve disease in the aging population and usage for young generation. The long-term durability of the biological valve including the risks of structural valve deterioration(SVD) is the major concern of the bio-Bentall procedure. Bio-Bentall in our hospital are reviewed and literature review are added. Our surgical results of long-term survival in bio-Bentall patients is acceptable compare to other study and freedom from SVD and reoperation is better than other results...
January 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29471415/blue-and-black-cloth-targets-effects-of-size-shape-and-color-on-stable-fly-diptera-muscidae-attraction
#18
Jerome A Hogsette, Lane D Foil
Stable fly management is challenging because of the fly's dispersal behavior and its tendency to remain on the host only while feeding. Optically attractive traps have been used to survey and sometimes reduce adult populations. Insecticide-treated blue and black cloth targets developed for tsetse fly management in Africa were found to be attractive to stable flies in the United States, and various evaluations were conducted in Louisiana and Florida. Tests using untreated targets were designed to answer questions about configuration, size, and color relative to efficacy and stability in high winds...
April 2, 2018: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29452638/nadh-shuttling-couples-cytosolic-reductive-carboxylation-of-glutamine-with-glycolysis-in-cells-with-mitochondrial-dysfunction
#19
Edoardo Gaude, Christina Schmidt, Payam A Gammage, Aurelien Dugourd, Thomas Blacker, Sew Peak Chew, Julio Saez-Rodriguez, John S O'Neill, Gyorgy Szabadkai, Michal Minczuk, Christian Frezza
The bioenergetics and molecular determinants of the metabolic response to mitochondrial dysfunction are incompletely understood, in part due to a lack of appropriate isogenic cellular models of primary mitochondrial defects. Here, we capitalize on a recently developed cell model with defined levels of m.8993T>G mutation heteroplasmy, mTUNE, to investigate the metabolic underpinnings of mitochondrial dysfunction. We found that impaired utilization of reduced nicotinamide adenine dinucleotide (NADH) by the mitochondrial respiratory chain leads to cytosolic reductive carboxylation of glutamine as a new mechanism for cytosol-confined NADH recycling supported by malate dehydrogenase 1 (MDH1)...
February 15, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29451801/patterns-of-carbon-nanotubes-by-flow-directed-deposition-on-substrates-with-architectured-topographies
#20
M K Jawed, N G Hadjiconstantinou, D M Parks, P M Reis
We develop and perform continuum mechanics simulations of carbon nanotube (CNT) deployment directed by a combination of surface topography and rarefied gas flow. We employ the discrete elastic rods method to model the deposition of CNT as a slender elastic rod that evolves in time under two external forces, namely, van der Waals (vdW) and aerodynamic drag. Our results confirm that this self-assembly process is analogous to a previously studied macroscopic system, the "elastic sewing machine", where an elastic rod deployed onto a moving substrate forms nonlinear patterns...
March 14, 2018: Nano Letters
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