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https://www.readbyqxmd.com/read/29331082/mechanistic-target-of-rapamycin-complex-1-and-2-in-human-temporal-lobe-epilepsy
#1
Delia M Talos, Leah M Jacobs, Sarah Gourmaud, Carlos A Coto, Hongyu Sun, Kuei-Cheng Lim, Timothy H Lucas, Kathryn A Davis, Maria Martinez-Lage, Frances E Jensen
OBJECTIVE: Temporal lobe epilepsy (TLE) is a chronic epilepsy syndrome defined by seizures and progressive neurological disabilities, including cognitive impairments, anxiety and depression. Here, human TLE specimens were investigated focusing on the mechanistic target of rapamycin (mTOR) Complex 1 (mTORC1) and Complex 2 (mTORC2) activities in the brain, as both pathways may represent unique targets for treatment. METHODS: Surgically resected hippocampal and temporal lobe samples from therapy-resistant TLE patients were analyzed by Western blotting to quantify the expression of established mTORC1 and mTORC2 activity markers and upstream or downstream signaling pathways involving the two complexes...
January 13, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29327519/psychiatric-co-morbidities-in-women-with-epilepsy
#2
Uma Sundar, Sonal Thakur Honrao, Nilesh Shah
Background: The co-existence of psychiatric co-morbidities with Epilepsy in women is multifactorial and complex, being closely related to hormonal status, medication side effects, and psychosocial factors. Aims: We aimed to study associated Psychiatric co-morbidities in women with Epilepsy (WWE), and correlate the same with seizure subtype and medication , compliance with treatment and seizure control. Material and Methods: This was a prospective, interview based study in OPD over 18 months, evaluating WWE over 13 years of age with at least 1 seizure in the last 1 year...
December 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29321700/validation-and-reliability-study-of-the-turkish-version-of-the-stigma-scale-of-epilepsy
#3
Nevin Kuloğlu Pazarci, Nihan Parasiz Yükselen, Şenay Aydın, Zeynep Ünlüsoy Acar, Dilek Necioğlu Örken
Introduction: We aimed to validate the Turkish version of the Stigma Scale of Epilepsy (SSE) (from Brazil) and present the results. Method: The SSE was completed by 33 patients with epilepsy (PWE), 25 of the patients' family members, and 23 people from the community. Subjects were interviewed on an individual basis; a physician read the questions and the subjects wrote the answers on a sheet. The form was the same for all subjects. In addition, the Beck Depression Inventory (BDI) and the Hamilton Anxiety Inventory (HAI), Short Form-36 (SF-36) were completed by the subjects...
December 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29320603/drug-management-for-acute-tonic-clonic-convulsions-including-convulsive-status-epilepticus-in-children
#4
REVIEW
Amy McTague, Timothy Martland, Richard Appleton
BACKGROUND: Tonic-clonic convulsions and convulsive status epilepticus (currently defined as a tonic-clonic convulsion lasting at least 30 minutes) are medical emergencies and require urgent and appropriate anticonvulsant treatment. International consensus is that an anticonvulsant drug should be administered for any tonic-clonic convulsion that has been continuing for at least five minutes. Benzodiazepines (diazepam, lorazepam, midazolam) are traditionally regarded as first-line drugs and phenobarbital, phenytoin and paraldehyde as second-line drugs...
January 10, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29306976/deep-brain-stimulation-of-the-anterior-nucleus-of-the-thalamus-for-drug-resistant-epilepsy
#5
REVIEW
Tim A M Bouwens van der Vlis, Olaf E M G Schijns, Frédéric L W V J Schaper, Govert Hoogland, Pieter Kubben, Louis Wagner, Rob Rouhl, Yasin Temel, Linda Ackermans
Despite the use of first-choice anti-epileptic drugs and satisfactory seizure outcome rates after resective epilepsy surgery, a considerable percentage of patients do not become seizure free. ANT-DBS may provide for an alternative treatment option in these patients. This literature review discusses the rationale, mechanism of action, clinical efficacy, safety, and tolerability of ANT-DBS in drug-resistant epilepsy patients. A review using systematic methods of the available literature was performed using relevant databases including Medline, Embase, and the Cochrane Library pertaining to the different aspects ANT-DBS...
January 6, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29305781/health-related-quality-of-life-in-mothers-of-children-with-epilepsy-10%C3%A2-years-after-diagnosis
#6
Klajdi Puka, Mark A Ferro, Kelly K Anderson, Kathy N Speechley
PURPOSE: Epilepsy in childhood extends far beyond seizures and affects child and parental well-being. The long-term impact of childhood-onset epilepsy on parental well-being is unknown. This study assessed health-related quality of life (HRQOL) in mothers 10 years after their child's diagnosis of epilepsy. METHODS: Data come from the Health-Related Quality of Life in Children with Epilepsy Study, a multicenter prospective cohort study of children with newly diagnosed epilepsy...
January 5, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29302214/antidepressant-drug-paroxetine-blocks-the-open-pore-of-kv3-1-potassium-channel
#7
Hyang Mi Lee, Ok Hee Chai, Sang June Hahn, Bok Hee Choi
In patients with epilepsy, depression is a common comorbidity but difficult to be treated because many antidepressants cause pro-convulsive effects. Thus, it is important to identify the risk of seizures associated with antidepressants. To determine whether paroxetine, a very potent selective serotonin reuptake inhibitor (SSRI), interacts with ion channels that modulate neuronal excitability, we examined the effects of paroxetine on Kv3.1 potassium channels, which contribute to highfrequency firing of interneurons, using the whole-cell patch-clamp technique...
January 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29301763/mental-disorder-in-children-with-physical-conditions-a-pilot-study
#8
Alexandra Butler, Ryan J Van Lieshout, Ellen Louise Lipman, Harriet L MacMillan, Andrea Gonzalez, Jan Willem Gorter, Kathy Georgiades, Kathy N Speechley, Michael H Boyle, Mark A Ferro
OBJECTIVES: Methodologically, to assess the feasibility of participant recruitment and retention, as well as missing data in studying mental disorder among children newly diagnosed with chronic physical conditions (ie, multimorbidity). Substantively, to examine the prevalence of multimorbidity, identify sociodemographic correlates and model the influence of multimorbidity on changes in child quality of life and parental psychosocial outcomes over a 6-month follow-up. DESIGN: Prospective pilot study...
January 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29289902/symptoms-of-anxiety-and-depression-and-family-s-quality-of-life-in-children-and-adolescents-with-epilepsy
#9
Carlo Cianchetti, Elisa Bianchi, Renzo Guerrini, Maria Giuseppina Baglietto, Marilena Briguglio, Simona Cappelletti, Susanna Casellato, Giovanni Crichiutti, Rosa Lualdi, Lucia Margari, Antonino Romeo, Ettore Beghi
INTRODUCTION: We studied children and adolescents with epilepsy (CAWE) and their families to evaluate symptoms of anxiety and depression, quality of life (QoL), and their correlations with epilepsy characteristics. MATERIAL AND METHODS: The study included 326 (52.5% females) 8 to 18years old CAWE. Anxiety and depression were assessed with the "Self-administered psychiatric scales for children and adolescents" (SAFA), and family's QoL with the parents' report "Impact of Epilepsy on QoL" (IEQoL)...
December 28, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29288827/antidepressant-like-effects-of-water-extract-of-gastrodia-elata-blume-on-neurotrophic-regulation-in-a-chronic-social-defeat-stress-model
#10
Yu-En Lin, Shao-Ting Chou, Shih-Hang Lin, Kuan-Hung Lu, Suraphan Panyod, Yi-Syuan Lai, Chi-Tang Ho, Lee-Yan Sheen
ETHNOPHARMACOLOGY RELEVANCE: Gastrodia elata Blume (GE) is a traditional Chinese medicine commonly used to treat dizziness, epilepsy, paralysis and some emotional symptoms in east Asia. We previously showed that the water extract of Gastrodia elata Blume (WGE) possesses anti-depression like effects in a forced swimming test and chronic mild stress model. AIM OF THE STUDY: The aim of this study was to investigate the antidepressant-like effects of WGE and potential mechanisms related to brain-derived neurotrophic factor (BDNF) regulation in mice exposed to chronic social defeat stress (CSDS) model...
December 27, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29287214/favorable-adverse-effect-profile-of-brivaracetam-vs-levetiracetam-in-a-preclinical-model
#11
Nathalie T Sanon, Jonathan Gagné, Daniele C Wolf, Soumia Aboulamer, Ciprian M Bosoi, Alexe Simard, Estelle Messiet, Sébastien Desgent, Lionel Carmant
Levetiracetam (LEV), and its newer selective analog brivaracetam (BRV), are two seizure medications that share an innovative mechanism of action targeting the Synaptic Vesicle Protein 2A (SV2A), altering neurotransmitter release and decreasing seizure frequency. Behavioral changes are the most significant adverse effects reported by patients taking LEV. We hypothesize that BRV, the more potent SV2A analog, could exert less behavioral side effects, as it requires lower doses than LEV. Using Kainic Acid (KA)-treated and control rats, we measured adverse behavioral effect profiles of LEV, BRV, or Saline, on social and nonsocial behaviors...
December 26, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29279188/clinical-correlates-of-negative-health-events-in-a-research-sample-with-epilepsy
#12
Neha Kumar, Kari Colon-Zimmermann, Edna Fuentes-Casiano, Hongyan Liu, Curtis Tatsuoka, Kristin A Cassidy, Mustafa Kahriman, Peijun Chen, Martha Sajatovic
AIMS: In spite of advances in care, people with epilepsy experience negative health events (NHEs), such as seizures, emergency department (ED) visits, and hospitalizations. Being able to identify characteristics that are associated with NHE risk can help inform care approaches that reduce complications and burden. This analysis using baseline data from a larger randomized epilepsy self-management clinical trial assessed the relationship between demographic and clinical variables vs. seizure-related complications among people with epilepsy...
December 23, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29278894/asymmetric-ataxia-depression-memory-loss-epilepsy-and-axonal-neuropathy-associated-with-a-heterozygous-dna-polymerase-gamma-variant-of-uncertain-significance-c1370g-a-r457q
#13
Nivedita U Jerath, Michael E Shy
INTRODUCTION: Mutations in the gene encoding DNA polymerase gamma (POLG) impair its ability to proofread mitochondrial DNA (mtDNA) during replication [1]. This results in a high frequency of randomly distributed mtDNA mutations and thus a wide range of phenotypes, including seizures, neuropathy, and cerebellar ataxia [1, 2]. We document a phenotype associated with the rare POLG variant c.1370G>A (p.R457Q). METHODS: Over 10 years, we performed electrodiagnostic and neuropsychologic on a patient who presented with a variety of neurologic symptoms...
December 20, 2017: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/29275064/role-of-physical-activity-and-exercise-in-alleviating-cognitive-impairment-in-people-with-epilepsy
#14
Jane B Allendorfer, Ricardo M Arida
Many persons with epilepsy (PWE) experience problems with a wide range of cognitive functions, including learning, memory, attention, and executive control. These deficits in cognition result in diminished quality of life for PWE and are related to many factors, including the etiology of their epilepsy, recurrent seizures, side effects of antiseizure medications, or a combination of these factors. Various treatments to ameliorate cognitive deficits experienced by PWE have been implemented, although noninvasive and nonpharmacologic strategies may be more appealing options due to their relatively low cost, reduced risk of side effects, and/or reduced potential interactions with antiseizure medications...
December 20, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29275022/-psychiatric-comorbidities-in-epilepsy
#15
Bertrand de Toffol, Coraline Hingray, Julien Biberon, Wissam El-Hage
Psychiatric comorbidities are overrepresented in people suffering from epilepsy in comparison to the general population. There is a two-way link between epilepsy and psychiatric disorders. Psychiatric symptomatology is specific in epilepsy, according to the chronology of symptoms in relation to the seizure (inter, pre- or postictal). Easy to use, fast and efficient self-administered questionnaires are available to evaluate depressive (NDDI-E) and generalized anxiety disorder (GAD-7) symptoms. Selective serotonin reuptake inhibitors (SSRIs) are not proconvulsant and can be safely used to treat depressive or anxious disorders...
December 20, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/29261511/biomechanistic-insights-into-the-roles-of-oxidative-stress-in-generating-complex-neurological-disorders
#16
Mohammad Yusuf, Maria Khan, Majed A Robaian, Riaz A Khan
Neurological diseases like Alzheimer's, epilepsy, Parkinsonism, depression, Huntington's disease, and amyotrophic lateral sclerosis prevailing globally are considered to be deeply influenced by oxidative stress based changes in the biochemical settings of the organs. The excess oxygen concentration triggers the production of reactive oxygen species and even the intrinsic antioxidant enzyme system, i.e., SOD, CAT and GSHPx fails to manage their levels and keep them under desirable limits. This consequently leads to oxidation of protein, lipids, and nucleic acids in the brain resulting in apoptosis, proteopathy, proteasomes and mitochondrion dysfunction, glial cell activation as well as neuroinflammation...
June 27, 2017: Biological Chemistry
https://www.readbyqxmd.com/read/29258968/refractory-chronic-epilepsy-associated-with-neuronal-auto-antibodies-could-perisylvian-semiology-be-a-clue
#17
Lisa Gillinder, Linda Tjoa, Basil Mantzioris, Stefan Blum, Sasha Dionisio
We report a case series of 10 patients with chronic medically refractory antibody-positive autoimmune epilepsy and assess their common clinical features. Immune-mediated seizures are most commonly reported in the context of encephalitis or encephalopathy, with few reports focusing on lone, chronic epilepsy in the outpatient setting. Our aim was to define the potential diagnostic clues that might be present in these cases, leading to consideration of an autoimmune cause of the epilepsy. We performed a retrospective review of all patients presenting to the outpatient department of our unit who underwent autoimmune screening...
December 20, 2017: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/29242256/manual-review-of-electronic-medical-records-as-a-reference-standard-for-case-definition-development-a-validation-study
#18
Tyler Williamson, Rebecca C Miyagishima, Janeen D Derochie, Neil Drummond
BACKGROUND: The Canadian Primary Care Sentinel Surveillance Network (CPCSSN) previously carried out a validation study of case definitions for 8 chronic diseases (diabetes mellitus, hypertension, osteoarthritis, depression, dementia, chronic obstructive pulmonary disease, parkinsonism and epilepsy) using direct review of "raw" electronic medical record data. Although effective, this method is time-consuming and can present methodological and organizational challenges. We aimed to determine whether the processed and standardized data contained with the CPCSSN database might function as a reference standard for case definition validation...
December 11, 2017: CMAJ Open
https://www.readbyqxmd.com/read/29240833/vagal-nerve-stimulation-triggers-widespread-responses-and-alters-large-scale-functional-connectivity-in-the-rat-brain
#19
Jiayue Cao, Kun-Han Lu, Terry L Powley, Zhongming Liu
Vagus nerve stimulation (VNS) is a therapy for epilepsy and depression. However, its efficacy varies and its mechanism remains unclear. Prior studies have used functional magnetic resonance imaging (fMRI) to map brain activations with VNS in human brains, but have reported inconsistent findings. The source of inconsistency is likely attributable to the complex temporal characteristics of VNS-evoked fMRI responses that cannot be fully explained by simplified response models in the conventional model-based analysis for activation mapping...
2017: PloS One
https://www.readbyqxmd.com/read/29239239/depressive-disorders-in-patients-with-pharmaco-resistant-mesial-temporal-lobe-epilepsy
#20
Eleonora Borges Gonçalves, Tania Aparecida Marchiori de Oliveira Cardoso, Clarissa Lin Yasuda, Fernando Cendes
Objectives To assess depressive disorders in patients with mesial temporal lobe epilepsy (MTLE) refractory to medical treatment. Methods Adult patients with refractory MTLE completed two questionnaires (Mini International Neuropsychiatric Interview (MINI) and the Beck Depression Inventory (BDI) had a semi-structured psychiatric interview and a high resolution MRI scan. For complete neuropsychiatric diagnosis, as per International Classification of Diseases (ICD-10), the results were combined with clinical history and additional information from the patients' family...
January 1, 2017: Journal of International Medical Research
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