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https://www.readbyqxmd.com/read/29145183/catastrophe-reaction-and-emotionalism
#1
Antonio Carota, Julien Bogousslavsky
The catastrophic reaction (CR; a disruptive and uncontrolled behavior triggered by anger, irritability, and hostility) and emotionalism (a condition of uncontrolled crying or laughing) are disorders of the emotional regulation and expression, the prevalence of which is underestimated in neurology. Their occurrence is an additional factor of poor outcome for neurologic patients. Although they have been recognized and completely described in their clinical manifestations more than a century ago, many issues remain unsolved regarding their pathogenesis and the respective role of the brain damage and psychological factors...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29115388/antinociceptive-effect-of-valeriana-fauriei-regulates-bdnf-signaling-in-an-animal-model-of-fibromyalgia
#2
Hwayoung Lee, Jiyun Im, Hansol Won, Jun Young Kim, Hyung-Ki Kim, Jun-Tack Kwon, Young Ock Kim, Sanghyun Lee, Ik-Hyun Cho, Sang Won Lee, Hak-Jae Kim
The genus Valeriana has been widely used in popular medicine for centuries, to treat sleep disorders, anxiety, epilepsy and insomnia. Recent studies have focused on the novel pharmacological effects of Valeriana fauriei Briq. (VF) species. Previous studies have attempted to determine the pharmacological functions of Valeriana in various human diseases, particularly with regards to its neuroprotective effects, and its ability to reduce pain and stress. The present study constructed an animal model of fibromyalgia (FM), which was induced by intermittent cold stress with slight modification...
October 20, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29111893/-psychological-health-of-children-with-chronic-physical-illness-and-their-parents-results-from-meta-analyses
#3
Martin Pinquart
Psychological Health of Children with Chronic Physical Illness and their Parents - Results from Meta-Analyses The present paper summarizes results from meta-analyses on psychological well-being of children with chronic physical illnesses and their parents. At the beginning, we discuss potential reasons for psychological effects of a chronic physical illness on children and adolescents as well as their parents. We then summarize results of meta-analyses of studies that compared aspects of mental health of children with a chronic physical illness and their parents with families of healthy children...
November 2017: Praxis der Kinderpsychologie und Kinderpsychiatrie
https://www.readbyqxmd.com/read/29108398/blockade-of-p75-neurotrophin-receptor-reverses-irritability-and-anxiety-related-behaviors-in-a-rat-model-of-status-epilepticus
#4
Soraya Mehrabi, Mahyar Janahamdi, Mohammad Taghi Joghataie, Mahmood Barati, Mohsen Marzban, Mahmoudreza Hadjighassem, Maryam Farahmandfar
Background: Many recent epidemiological studies have shown that epileptic patients are more likely suffer from depression, anxiety, and irritability. However, the cellular mechanisms of epilepsy-induced psychotic behaviors are not fully elucidated. Neurotrophin receptors have been suggested to be involved in epilepsy and also in psychiatric disorders. Up-regulation of p75NTR expression and activation of p75NTR signalling cascades after the seizure have been shown, but the role of the p75 receptor in epilepsy-induced psychotic behaviors has not been documented so far...
November 7, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/29107450/epilepsy-as-a-network-disorder-1-what-can-we-learn-from-other-network-disorders-such-as-autistic-spectrum-disorder-and-mood-disorders
#5
REVIEW
Andres M Kanner, Helen Scharfman, Nathalie Jette, Evdokia Anagnostou, Christophe Bernard, Carol Camfield, Peter Camfield, Karen Legg, Ilan Dinstein, Peter Giacobe, Alon Friedman, Bernd Pohlmann-Eden
Epilepsy is a neurologic condition which often occurs with other neurologic and psychiatric disorders. The relation between epilepsy and these conditions is complex. Some population-based studies have identified a bidirectional relation, whereby not only patients with epilepsy are at increased risk of suffering from some of these neurologic and psychiatric disorders (migraine, stroke, dementia, autism, depression, anxiety disorders, Attention deficit hyperactivity disorder (ADHD), and psychosis), but also patients with these conditions are at increased risk of suffering from epilepsy...
October 26, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29107200/the-association-of-psychosocial-variables-with-adherence-to-antiepileptic-drugs-in-patients-with-temporal-lobe-epilepsy
#6
Shan Wang, Cong Chen, Bo Jin, Linglin Yang, Yao Ding, Yi Guo, Yi Chen, Shuang Wang, Meiping Ding
OBJECTIVE: The aim of this study was to explore the association between psychosocial factors and adherence to antiepileptic drugs (AEDs) in patients with temporal lobe epilepsy (TLE). METHODS: This cross-sectional study was conducted with 123 individuals with TLE, admitted to our epilepsy center from December 2015 to May 2017. The participants completed standardized self-report questionnaires measuring medication adherence, anxiety, depression, and family and social support...
October 26, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29107199/kindling-epileptogenesis-and-panic-like-behavior-their-bidirectional-connection-and-contribution-to-epilepsy-associated-depression
#7
Jesús-Servando Medel-Matus, Don Shin, Raman Sankar, Andrey Mazarati
Anxiety is one of the most common comorbidities of epilepsy, which has major detrimental effects on the quality of life. Generalized anxiety disorder (GAD) associated with epilepsy has been receiving most attention. However, several other forms of anxiety reportedly present in patients with epilepsy, including panic disorder (PD). In this study, using an animal model of limbic epilepsy, we examined the interplay between epilepsy and panic-like behavior (PLB). Further, considering the high degree of comorbidity between depression on the one hand, and both epilepsy and PD on the other hand, we studied whether and how the presence of PLB in animals with epilepsy would affect their performance in depression-relevant tests...
October 26, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29100462/the-role-of-substance-p-in-epilepsy-and-seizure-disorders
#8
REVIEW
Xue Feng Wang, Tong Tong Ge, Jie Fan, Wei Yang, Ran Ji Cui
A range of evidence implicates the neuropeptide substance P (SP), a member of the tachykinin family, in emotional behavior, anxiety, pain, and inflammation. Recently, SP has been implicated in susceptibility to seizures, for which a potential proconvulsant role was indicated. Indeed, antagonists of a specific SP receptor, neurokinin-1 receptor, were found to attenuate kainic acid (KA)-induced seizure activity. However, detailed mechanisms of SP regulation in epilepsy remain obscure. In this review, we summarize the present literature to expound the role of SP in epilepsy, and provide hypotheses for potential mechanisms...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29096164/potential-factors-impacting-health-related-quality-of-life-among-patients-with-epilepsy-results-from-the-united-arab-emirates
#9
Taoufik Alsaadi, Seada Kassie, Khadija El Hammasi, Tarek M Shahrour, Mustafa Shakra, Lamya Turkawi, Wassim Nasreddine, Mufeed Raoof
PURPOSE: to investigate potential factors impacting HRQOL among PWE at a medical facility in the UAE. METHODS: Depression, anxiety, and health-related quality of life were assessed in 160 adult patients with epilepsy from September 2014 to January 2015 at Sheikh Khalifa Medical City (SKMC). The World Health Organization Quality of Life abbreviated scale (WHOQOL-BREF), the Patient Health Questionnaire nine-item (PHQ-9) depression scale, and Generalized Anxiety Disorder seven-item (GAD-7) scale were administered...
October 28, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29073181/modulation-of-t-type-ca2-channels-by-lavender-and-rosemary-extracts
#10
Chaymae El Alaoui, Jean Chemin, Taoufiq Fechtali, Philippe Lory
Medicinal plants represent a significant reservoir of unexplored substances for early-stage drug discovery. Of interest, two flowering Mediterranean plants have been used for thousands of years for their beneficial effects on nervous disorders, including anxiety and mood. However, the therapeutic potential of these plants regarding their ability to target ion channels and neuronal excitability remains largely unknown. Towards this goal, we have investigated the ability of Lavender and Rosemary to modulate T-type calcium channels (TTCCs)...
2017: PloS One
https://www.readbyqxmd.com/read/29046989/epilepsy-and-psychiatric-comorbidities-drug-selection
#11
REVIEW
Marco Mula
Purpose of review The pharmacological treatment of patients with epilepsy and psychiatric comorbidities may sometimes represent a therapeutic challenge. This review is focused on the pharmacological management of patients with epilepsy and psychiatric problems in terms of rationalization of the antiepileptic drug (AED) treatment and the pharmacological management of the most clinically relevant psychiatric comorbidities, namely mood and anxiety disorders, psychoses, and attention deficit hyperactivity disorder (ADHD)...
October 19, 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29043247/clinic-based-mobile-health-decision-support-to-enhance-adult-epilepsy-self-management-an-intervention-mapping-approach
#12
Ross Shegog, Charles E Begley
INTRODUCTION: Epilepsy is a neurological disorder involving recurrent seizures. It affects approximately 5 million people in the U.S. To optimize their quality of life people with epilepsy are encouraged to engage in self-management (S-M) behaviors. These include managing their treatment (e.g., adhering to anti-seizure medication and clinical visit schedules), managing their seizures (e.g., responding to seizure episodes), managing their safety (e.g., monitoring and avoiding environmental seizure triggers), and managing their co-morbid conditions (e...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29042065/analgesic-and-anxiolytic-effects-of-leu-31-pro-34-neuropeptide-y-microinjected-into-the-periaqueductal-gray-in-rats
#13
Priscila Vázquez-León, Luis G Mendoza-Ruiz, Eduardo Ramírez-San Juan, German Alberto Chamorro-Cevallos, Abraham Miranda-Páez
Several reports have demonstrated that neuropeptide Y (NPY) is involved in food intake, epilepsy, circadian rhythms, drug seeking, pain and anxiety, and other physiological or pathological conditions. On the other hand, periaqueductal gray (PAG) is a key brain center for modulating pain, anxiety and fear. It is the main structure implicated in integrated defensive behaviors. One such behavior, tonic immobility (TI), resembles fear and is able to induce analgesia. After microinjection of [Leu(31),Pro(34)]-Neuropeptide Y ([Leu(31),Pro(34)]-NPY) into the PAG dorsal (D) or ventrolateral (VL) of adult male Wistar rats, the following parameters were assessed: i) the analgesic effect by means of the tail-flick test (TF), ii) the duration of TI as a passive defensive behavioral response and as an anxiety/fear model (considering both TF and TI as single behaviors), iii) TI-induced analgesia by the combination of TF/TI, and iv) the anxious-like state through the elevated plus maze (EPM), and defensive burying behavior (DBB)...
October 12, 2017: Neuropeptides
https://www.readbyqxmd.com/read/29037336/neuropsychiatry-towards-a-philosophy-of-praxis
#14
Jesús Ramirez-Bermudez, Rodrigo Perez-Esparza, Luis Carlos Aguilar-Venegas, Perminder Sachdev
Neuropsychiatry is a specialized clinical, academic and scientific discipline with its field located in the borderland territory between neurology and psychiatry. In this article, we approach the theoretical definition of neuropsychiatry, and in order to address the practical aspects of the discipline, we describe the profile of a neuropsychiatric liaison service in the setting of a large hospital for neurological diseases in a middle-income country. An audit of consecutive in-patients requiring neuropsychiatric assessment at the National Institute of Neurology and Neurosurgery of Mexico is reported, comprising a total of 1212 patients...
October 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/29035798/sexual-function-and-related-factors-in-iranian-woman-with-epilepsy
#15
Zahra Atarodi-Kashani, Nourossadat Kariman, Abbas Ebadi, Hamid Alavi Majd, Nahid Beladi-Moghadam
PURPOSE: Epileptic women are faced with many sexual challenges in their life due to medical and non-medical factors. The present study was conducted to assess sexual function in epileptic women and its related factors. METHOD: The present cross-sectional study was conducted on 196 epileptic married women of reproductive age who were members of the Iranian Epilepsy Association and were selected continuously over six months through convenience sampling. The data collection tools included the Female Sexual Function Index (FSFI) and questions about the causes of sexual dysfunction...
October 5, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29023704/gabaa-receptor-subunits-in-the-human-amygdala-and-hippocampus-immunohistochemical-distribution-of-7-subunits
#16
Harald Stefanits, Ivan Milenkovic, Nina Mahr, Ekaterina Pataraia, Johannes A Hainfellner, Gabor G Kovacs, Werner Sieghart, Deniz Yilmazer-Hanke, Thomas Czech
GABAergic neurotransmission in the amygdala contributes to the regulation of emotional processes in anxiety, stress, reward, mnestic functions, addiction, and epilepsy. Species-specific differences in the distribution and composition of GABAA receptors may account for distinct effects and side-effects of GABAergic agents. However, data on the distribution and composition of GABAA receptors in the human amygdala are lacking. Here, the expression of GABAA receptor subunits α1, α2, α3, α5, β2, β2/3 and γ2 was studied in the human amygdala using immunohistochemistry...
October 12, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29016856/neuronal-overexpression-of-ube3a-isoform-2-causes-behavioral-impairments-and-neuroanatomical-pathology-relevant-to-15q11-2-q13-3-duplication-syndrome
#17
Nycole A Copping, Sarah G B Christian, Dylan J Ritter, M Saharul Islam, Nathalie Buscher, Dorota Zolkowska, Michael C Pride, Elizabeth L Berg, Janine M LaSalle, Jacob Ellegood, Jason P Lerch, Lawrence T Reiter, Jill L Silverman, Scott V Dindot
Maternally derived copy number gains of human chromosome 15q11.2-q13.3 (Dup15q syndrome or Dup15q) cause intellectual disability, epilepsy, developmental delay, hypotonia, speech impairments, and minor dysmorphic features. Dup15q syndrome is one of the most common and penetrant chromosomal abnormalities observed in individuals with autism spectrum disorder (ASD). Although ∼40 genes are located in the 15q11.2-q13.3 region, overexpression of the ubiquitin-protein E3A ligase (UBE3A) gene is thought to be the predominant molecular cause of the phenotypes observed in Dup15q syndrome...
October 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28990169/methylphenidate-cognition-and-epilepsy-a-1-month-open-label-trial
#18
Jesse Adams, Valerie Alipio-Jocson, Katherine Inoyama, Victoria Bartlett, Saira Sandhu, Jemima Oso, John J Barry, David W Loring, Kimford J Meador
OBJECTIVE: Cognitive difficulties are common in epilepsy. Beyond reducing seizures and adjusting antiepileptic medications, no well-validated treatment exists in adults. Methylphenidate is used effectively in children with epilepsy and attention-deficit/hyperactivity disorder, but its effects in adults have not been systematically evaluated. We hypothesized that methylphenidate can safely improve cognition in adults with epilepsy. We detail here the open-label follow-up to a double-blind, placebo-controlled, single-dose study...
October 9, 2017: Epilepsia
https://www.readbyqxmd.com/read/28986332/anticonvulsant-effects-of-senna-spectabilis-on-seizures-induced-by-chemicals-and-maximal-electroshock
#19
Gisele Claudine Nkamguie Nkantchoua, Jacqueline Stephanie Kameni Njapdounke, Jean Jules Fifen, Germain Sotoing Taiwe, Lucie Josiane Ojong, Antoine Kavaye Kandeda, Elisabeth Ngo Bum
Senna spectabilis (Fabaceae) is one of the medicinal plants used in Cameroon by traditional healers to treat epilepsy, constipation, insomnia, anxiety. The present study aimed to investigate the anticonvulsant effects of Senna spectabilis decoction on seizures induced by maximal electroshock (MES), pentylenetetrazole (PTZ), pilocarpine (PC) and its possible action mechanisms in animal models using flumazenil (FLU), methyl-ß-carboline-3-carboxylate (BC) and bicuculline (BIC). Senna spectabilis decoction (106...
October 3, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28953844/psychiatric-manifestation-of-patients-with-epilepsy-in-mosul-iraq
#20
Khalid Omar Sultan, Bashar Shaker Mahmood, Zainab Najim, Dhiher Jameel Al-Habboo, Hellme Najim
BACKGROUND: It has been proven that physical morbidity is related to psychiatric illness. Some physical illnesses are more related to psychiatric morbidity compared to others. Epilepsy is considered one of them, as patients who suffer from epilepsy has disturbances of consciousness and this leads to a variety of psychological disturbance in addition to the psychological and social impact of the illness. AIMS: To identify risk factors and psychiatric morbidity in epilepsy, in order to try to manage it and improve outcome of this illness and enhance quality of life...
September 2017: Psychiatria Danubina
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