gringmuth

Children with high-risk SHH/ TP53 -mut and Group 3 medulloblastoma (MB) have a 5-year overall survival of only 40%. Innovative approaches to enhance survival while preventing adverse effects are urgently needed. We investigated an innovative therapy approach combining irradiation (RT), decitabine (DEC), and abacavir (ABC) in a patient-derived orthotopic SHH/ TP53 -mut and Group 3 MB mouse model. MB-bearing mice were treated with DEC, ABC and RT. Mouse survival, tumor growth (BLI, MRT) tumor histology (H/E), proliferation (Ki-67), and endothelial (CD31) staining were analyzed...

BACKGROUND: The inflammatory profiles of patients with acute and chronic nonspecific low back pain (LBP) patients are distinct. Spinal manipulative therapy (SMT) has been shown to modulate the production of nociceptive chemokines differently in these patient cohorts. The present study further investigates the effect(s) of SMT on other inflammatory mediators in the same LBP patient cohorts. METHODS: Acute (n = 22) and chronic (n = 25) LBP patients with minimum pain scores of 3 on a 10-point numeric scale, and asymptomatic controls (n = 24) were recruited according to stringent exclusion criteria...

Background: Adductor strains are the most commonly reported muscle injuries in adolescent soccer players and the second most common muscle injuries in adult players. Health practitioners should be aware of possible differential diagnoses, such as a pubic stress fracture or pubic apophysitis when athletes present with chronic groin pain. Purpose: To present a rare case of a unilateral pelvic stress fracture of a 16-year old elite soccer player with a history of Crohn's disease...

RNA interference (RNAi)-based strategies that mediate the specific knockdown of target genes by administration of small interfering RNAs (siRNAs) could be applied for treatment of presently incurable neurodegenerative diseases such as Parkinson's disease. However, inefficient delivery of siRNA into neurons hampers in vivo application of RNAi. We have previously established the 4-12 kDa branched polyethylenimine (PEI) F25-LMW with superior transfection efficacy for delivery of siRNA in vivo. Here, we present that siRNA complexed with this PEI extensively distributes across the CNS down to the lumbar spinal cord after a single intracerebroventricular infusion...

INTRODUCTION: With over 200 million amateur players worldwide, soccer is one of the most popular and internationally recognized sports today. By understanding how and why soccer injuries occur we hope to reduce prevalent injuries amongst elite soccer athletes. METHODS: Via a prospective cohort, we examined both male and female soccer players eligible to train with the Ontario Soccer Association provincial program between the ages of 13 to 17 during the period of October 10, 2008 and April 20, 2012...

OBJECTIVE: To create awareness of myositis ossificans (MO) as a potential complication of muscle contusion by presenting its clinical presentation and diagnostic features. An effective method of treatment is offered for those patients who develop traumatic MO. MANAGEMENT: Patients in this case series developed traumatic MO, confirmed on diagnostic ultrasound. Patients participated in a treatment regimen consisting of phonophoresis of acetic acid with ultrasound...

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OBJECTIVE: To present the diagnostic, clinical features, and management of Kienbock's disease and create awareness of the differential diagnosis of this condition in patients presenting with insidious, progressive dorsal wrist pain. CLINICAL FEATURES: A 23-year old male varsity football player presented with insidious progressive dorsal sided wrist pain with reduced wrist flexion and extension. A diagnosis of Kienbock's disease was made based on radiographs and magnetic resonance imaging...

OBJECTIVE: To detail the presentation of two elite female soccer players with right thigh pain that occurred during training. This article will outline the investigation, diagnosis and management of their cases. CLINICAL FEATURES: The patients presented with anterior thigh pain following injuries incurred during training camp. Both were diagnosed with acute muscular strain and associated muscular hematomas. The plans of management included rest and removal from sport, cryotherapy, and interferential current...

AIMS: Microvessel densities in cancers have been shown to be a prognostic factor for some types of cancer. For colorectal cancer, however, the situation is far from clear. METHODS: A consecutive series of 173 colorectal carcinomas was investigated, and to these were added 55 liver metastases originating from colorectal cancer. Microvessels were counted in hotspots (factor VIII immunostaining, 0.74 mm2). The capillary architecture was scored according to the degree of order and envelopment of the neoplastic glands...

Report of the clinical, biochemical, hemodynamic and x-ray data of a girl, 16 years of age, who had a narrowing of the abdominal aorta (diaphragmatic type). The stenosis was proximal to the renal arteries and was associated with unobtainable arterial pressure in the lower extremities and with hypertension in the arms. Although mechanical factors seemed to play the primary role in the production of hypertension, a further important factor inducing hypertension was the activation of the renin-angiotensin-aldosteron-system caused by reduced renal circulation...

No abstract text is available yet for this article.

No abstract text is available yet for this article.

No abstract text is available yet for this article.

No abstract text is available yet for this article.

No abstract text is available yet for this article.