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https://www.readbyqxmd.com/read/28432999/effect-of-intra-oral-aging-on-t%C3%A2-m-phase-transformation-microstructure-and-mechanical-properties-of-y-tzp-dental-ceramics
#1
Luciana Meireles Miragaya, Renato Bastos Guimarães, Rodrigo Othávio de Assunção E Souza, Glauco Dos Santos Botelho, José Guilherme Antunes Guimarães, Eduardo Moreira da Silva
The aim of the present study was to evaluate the influence of intra-oral aging on the tetragonal-to-monoclinic (t→m) phase transformation of two Y-TZP dental ceramics - Lava Frame (Frame) and Lava Plus (Plus) - and determine the impact of this response on their microstructures and mechanical properties: flexural strength, Young's modulus, microhardness and fracture toughness. Standardized ceramic specimens were analyzed by X-ray diffraction (XRD), scanning electron microscopy (SEM) and atomic force microscopy (AFM)...
April 13, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28431521/a-reference-floral-transcriptome-of-sexual-and-apomictic-paspalum-notatum
#2
Juan Pablo A Ortiz, Santiago Revale, Lorena A Siena, Maricel Podio, Luciana Delgado, Juliana Stein, Olivier Leblanc, Silvina C Pessino
BACKGROUND: Paspalum notatum Flügge is a subtropical grass native to South America, which includes sexual diploid and apomictic polyploid biotypes. In the past decade, a number of apomixis-associated genes were discovered in this species through genetic mapping and differential expression surveys. However, the scarce information on Paspalum sequences available in public databanks limited annotations and functional predictions for these candidates. RESULTS: We used a long-read 454/Roche FLX+ sequencing strategy to produce robust reference transcriptome datasets from florets of sexual and apomictic Paspalum notatum genotypes and delivered a list of transcripts showing differential representation in both reproductive types...
April 21, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28431366/efficacy-and-safety-of-a-video-eeg-protocol-for-genetic-generalized-epilepsies
#3
Luciana Rodrigues De Marchi, Jeana Torres Corso, Ana Carolina Zetehaku, Carina Gonçalves Pedroso Uchida, Mirian Salvadori Bittar Guaranha, Elza Márcia Targas Yacubian
INTRODUCTION: Video-EEG has been used to characterize genetic generalized epilepsies (GGE). For best performance, sleep recording, photic stimulation, hyperventilation, and neuropsychological protocols are added to the monitoring. However, risks and benefits of these video-EEG protocols are not well established. The aim of this study was to analyze the efficacy and safety of a video-EEG neuropsychological protocol (VNPP) tailored for GGE and compare its value with that of routine EEG (R-EEG)...
April 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28428649/role-of-magnetic-resonance-imaging-in-the-planning-of-breast-cancer-treatment-strategies-comparison-with-conventional-imaging-techniques
#4
Luciana Karla Lira França, Almir Galvão Vieira Bitencourt, Hugo Lamartine Souza Paiva, Caroline Baptista Silva, Nara Pacheco Pereira, Jociana Paludo, Luciana Graziano, Camila Souza Guatelli, Juliana Alves de Souza, Elvira Ferreira Marques
OBJECTIVE: To assess the role of magnetic resonance imaging (MRI) in the planning of breast cancer treatment strategies. MATERIALS AND METHODS: The study included 160 women diagnosed with breast cancer, who underwent breast MRI for preoperative staging. Using Pearson's correlation coefficient (r), we compared the size of the primary tumor, as determined by MRI, by conventional imaging (mammography and ultrasound), and in the pathological examination (gold standard)...
March 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/28427846/vaccines-are-different-a-systematic-review-of-budget-impact-analyses-of-vaccines
#5
REVIEW
Priscilla Magalhaes Loze, Luciana Bertholim Nasciben, Ana Marli Christovam Sartori, Alexander Itria, Hillegonda Maria Dutilh Novaes, Patrícia Coelho de Soárez
INTRODUCTION: Several countries require manufacturers to present a budget impact analysis (BIA), together with a cost-effectiveness analysis, to support national funding requests. However, guidelines for conducting BIA of vaccines are scarce. OBJECTIVES: To analyze the methodological approaches used in published budget impact analysis (BIA) of vaccines, discussing specific methodological issues related to vaccines. MATERIAL AND METHODS: This systematic review of the literature on BIA of vaccines was carried out in accordance with the Centre for Reviews and Dissemination - CRD guidelines...
April 17, 2017: Vaccine
https://www.readbyqxmd.com/read/28427532/nanotechnology-for-food-packaging-and-food-quality-assessment
#6
Marco Rossi, Daniele Passeri, Alberto Sinibaldi, Mariglen Angjellari, Emanuela Tamburri, Angela Sorbo, Elisabetta Carata, Luciana Dini
Nanotechnology has paved the way to innovative food packaging materials and analytical methods to provide the consumers with healthier food and to reduce the ecological footprint of the whole food chain. Combining antimicrobial and antifouling properties, thermal and mechanical protection, oxygen and moisture barrier, as well as to verify the actual quality of food, e.g., sensors to detect spoilage, bacterial growth, and to monitor incorrect storage conditions, or anticounterfeiting devices in food packages may extend the products shelf life and ensure higher quality of foods...
2017: Advances in Food and Nutrition Research
https://www.readbyqxmd.com/read/28427453/the-italian-society-for-pediatric-nephrology-sinepe-consensus-document-on-the-management-of-nephrotic-syndrome-in-children-part-i-diagnosis-and-treatment-of-the-first-episode-and-the-first-relapse
#7
REVIEW
Andrea Pasini, Elisa Benetti, Giovanni Conti, Luciana Ghio, Marta Lepore, Laura Massella, Daniela Molino, Licia Peruzzi, Francesco Emma, Carmelo Fede, Antonella Trivelli, Silvio Maringhini, Marco Materassi, Giovanni Messina, Giovanni Montini, Luisa Murer, Carmine Pecoraro, Marco Pennesi
This consensus document is aimed at providing an updated, multidisciplinary overview on the diagnosis and treatment of pediatric nephrotic syndrome (NS) at first presentation. It is the first consensus document of its kind to be produced by all the pediatric nephrology centres in Italy, in line with what is already present in other countries such as France, Germany and the USA. It is based on the current knowledge surrounding the symptomatic and steroid treatment of NS, with a view to providing the basis for a separate consensus document on the treatment of relapses...
April 21, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28426972/unlocking-the-chromatin-of-adenoid-cystic-carcinomas-using-hdac-inhibitors-sensitize-cancer-stem-cells-to-cisplatin-and-induces-tumor-senescence
#8
Luciana O Almeida, Douglas M Guimarães, Manoela D Martins, Marco A T Martins, Kristy A Warner, Jacques E Nör, Rogerio M Castilho, Cristiane H Squarize
No abstract text is available yet for this article.
April 8, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28426837/the-high-prevalence-of-hpv-and-hpv16-european-variants-in-cervical-and-anal-samples-of-hiv-seropositive-women-with-normal-pap-test-results
#9
Lays Paula Bondi Volpini, Neide Aparecida Tosato Boldrini, Luciana Bueno de Freitas, Angelica Espinosa Miranda, Liliana Cruz Spano
Human Immunodeficiency Virus (HIV)-seropositive women are more likely to have anogenital cancer, and high risk-HPV (HR-HPV) infection is the main associated factor. Between August 2013 and December 2015, we conducted a descriptive study to determine the HPV genotypes and HPV16 variants in cervical and anal samples of HIV-seropositive women with a normal Pap test. The viral DNA was amplified by PCR using the PGMY09/11 set of primers. Reverse line blot (RLB), restriction fragment length polymorphism (RFLP) and sequencing assays were used to determine the HPV genotypes...
2017: PloS One
https://www.readbyqxmd.com/read/28426389/melatonin-and-circadian-rhythms-in-autism-case-report
#10
Gabriela Melloni Zuculo, Bruno S B Gonçalves, Clay Brittes, Luiz Menna-Barreto, Luciana Pinato
Among the most co-occurring conditions in autism spectrum disorders (ASD), there are sleep disorders which may exacerbate associated behavioral disorders and lead to intensification of existing autistic symptoms. Several studies investigating the use of melatonin in the treatment of sleep disorders in ASD have shown comparative efficiency in sleep with little or no side effects. Here we report a case of ASD with non-24-hour rhythm and the effect of melatonin in circadian parameters by actigraphy. Visual analysis of the first 10 days recorded and the periodogram suggest that this patient showed a non-24-hour rhythm...
2017: Chronobiology International
https://www.readbyqxmd.com/read/28425704/an-ortho-iminoquinone-compound-reacts-with-lysine-inhibiting-aggregation-while-remodeling-mature-amyloid-fibrils
#11
Luiza Fernandes, Nathália Moraes, Fernanda Savacini Sagrillo, Augusto V Magalhães, Marcela Cristina de Moraes, Luciana Romão, Jeffery W Kelly, Debora Foguel, Neil P Grimster, Fernando L Palhano
Protein aggregation is a hallmark of several neurodegenerative diseases, including Alzheimer's and Parkinson's diseases. It has been shown that lysine residues play a key role in the formation of these aggregates. Thus the ability to disrupt aggregate formation by covalently modifying lysine residues could lead to the discovery of therapeutically relevant anti-amyloidogenesis compounds. Herein, we demonstrate that an ortho-iminoquinone (IQ) can be utilized to inhibit amyloid aggregation. Using alpha-synuclein and Aβ1-40 as model systems, we observed that IQ was able to react with lysine residues and reduce amyloid aggregation...
April 20, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28424847/characterization-of-microtubule-buckling-in-living-cells
#12
Carla Pallavicini, Alejandro Monastra, Nicolás González Bardeci, Diana Wetzler, Valeria Levi, Luciana Bruno
Microtubules are filamentous biopolymers involved in essential biological processes. They form key structures in eukaryotic cells, and thus it is very important to determine the mechanisms involved in the formation and maintenance of the microtubule network. Microtubule bucklings are transient and localized events commonly observed in living cells and characterized by a fast bending and its posterior relaxation. Active forces provided by molecular motors have been indicated as responsible for most of these rapid deformations...
April 19, 2017: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/28424415/clinicopathological-features-and-outcome-of-chronic-lymphocytic-leukaemia-in-chinese-patients
#13
Thomas Sau-Yan Chan, Yuh-Shan Lee, Ilaria Del Giudice, Marilisa Marinelli, Caterina Ilari, Luciana Cafforio, Anna Guarini, Daryl Tan, Colin Phipps, Yeow-Tee Goh, William Hwang, Allan Zhi-Kai Goh, Lisa Lai-Ping Siu, Saliangi Wu, Chun-Yin Ha, Shek-Ying Lin, Chi-Hang Kwok, Chi-Kuen Lau, Kit-Fai Wong, Robin Foà, Yok-Lam Kwong, Eric Tse
Chronic lymphocytic leukaemia (CLL) is uncommon in Chinese population and its biology, genetics and treatment outcome in Chinese patients have not been comprehensively investigated. In this study, we studied the clinicopathological features and outcome of 212 Chinese patients with newly diagnosed CLL in Hong Kong and Singapore. The median age at diagnosis was 64 years. The majority of patients presented with early-stage disease (Binet stage A, 56.1%). Del(13)(q14) was the most frequent abnormality (41.7%) detected by fluorescence in situ hybridization (FISH) analysis...
March 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423089/phenotypic-and-genotypic-detection-of-candida-albicans-and-candida-dubliniensis-strains-isolated-from-oral-mucosa-of-aids-pediatric-patients
#14
Harisson Oliveira Livério, Luciana da Silva Ruiz, Roseli Santos de Freitas, Angela Nishikaku, Ana Clara de Souza, Claudete Rodrigues Paula, Carina Domaneschi
The aim of this study was to assess a collection of yeasts to verify the presence of Candida dubliniensis among strains isolated from the oral mucosa of AIDS pediatric patients which were initially characterized as Candida albicans by the traditional phenotypic method, as well as to evaluate the main phenotypic methods used in the discrimination between the two species and confirm the identification through genotypic techniques, i.e., DNA sequencing. Twenty-nine samples of C. albicans isolated from this population and kept in a fungi collection were evaluated and re-characterized...
April 13, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28423074/7-epi-griffonilide-a-new-lactone-from-bauhinia-pentandra-complete-1h-and-13c-chemical-shift-assignments
#15
Macia C S DE Almeida, Luciana G S Souza, Daniele A Ferreira, Francisco C L Pinto, Débora R DE Oliveira, Gilvandete M P Santiago, Francisco J Q Monte, Raimundo Braz-Filho, Telma L G DE Lemos
A new lactone, 7-epi-griffonilide (1), and six known compounds, 2, 3a - 3c, 4a and 4b, were isolated from the leaves of Bauhinia pentandra (Fabaceae). The structures elucidation of 1 and 2 were based on detailed 2D NMR techniques and spectral comparison with related compounds, leading to complete assignment of the 1H and 13C NMR spectra.
January 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28420731/distinct-modulatory-role-of-rna-in-the-aggregation-of-the-tumor-suppressor-protein-p53-core-domain
#16
Petar Stefanov Kovachev, Debapriya Banerjee, Luciana Pereira Rangel, Jonny Eriksson, Murilo M Pedrote, Mafalda Maria D C Martins-Dinis, Katarina Edwards, Yraima Cordeiro, Jerson L Silva, Suparna Sanyal
Inactivation of the tumor suppressor protein p53 by mutagenesis, chemical modification, protein-protein interaction or aggregation has been associated with different human cancers. Although DNA is the typical substrate of p53, numerous studies have reported p53 interactions with RNA. Here, we have examined the effects of RNA of varied sequence, length and origin on the mechanism of aggregation of the core domain of p53 (p53C) using light scattering, intrinsic fluorescence, transmission electron microscopy, thioflavin-T binding, seeding and immunoblot assays...
April 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28419827/antihyperglycemic-antioxidant-activities-of-tucum%C3%A3-oil-astrocaryum-vulgare-in-alloxan-induced-diabetic-mice-and-identification-of-fatty-acid-profile-by-gas-chromatograph-new-natural-source-to-treat-hyperglycemia
#17
Matheus D Baldissera, Carine F Souza, Thirssa H Grando, Luciana F Cossetin, Michele R Sagrillo, Kátia Nascimento, Aleksandro S da Silva, Alencar K Machado, Ivana B M da Cruz, Lenita M Stefani, Bruna Klein, Roger Wagner, Silvia G Monteiro
The aim of the study was to investigate the effect of the oral administration of tucumã oil (Astrocaryum vulgare) on glucose and insulin levels, oxidative status, and pancreatic genotoxic parameters of alloxan-induced diabetic mice. The animals were divided into four groups (n = 6 each): control/water; control/tucumã oil; diabetic/water; diabetic/tucumã oil treated for 14 days with 5.0 mL kg(-1) via oral gavage. Gas chromatograph characterization demonstrated that oleic/elaidic fatty acid is the most abundant component present in this oil, followed by palmitic and stearic fatty acids...
April 15, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28415715/epha3-acts-as-proangiogenic-factor-in-multiple-myeloma
#18
Antonella Caivano, Francesco La Rocca, Ilaria Laurenzana, Tiziana Annese, Roberto Tamma, Ubaldo Famigliari, Vittorio Simeon, Stefania Trino, Luciana De Luca, Oreste Villani, Simona Berardi, Antonio Basile, Angelo Vacca, Giuseppe Saglio, Luigi Del Vecchio, Pellegrino Musto, Daniela Cilloni
This study investigates the role of ephrin receptor A3 (EphA3) in the angiogenesis of Multiple Myeloma (MM) and the effects of a selective target of EphA3 by a specific monoclonal antibody on primary bone marrow endothelial cells (ECs) of MM patients.EphA3 mRNA and protein were evaluated in ECs of MM patients (MMECs), in ECs of patients with monoclonal gammopathies of undetermined significance (MGECs) and in ECs of healthy subjects (control ECs). The effects of EphA3 targeting by mRNA silencing (siRNA) or by the anti EphA3 antibody on the angiogenesis were evaluated...
March 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414035/bothrops-jararaca-venom-gland-secretory-cells-in-culture-effects-of-noradrenaline-on-toxin-production-and-secretion
#19
Luciana Godoy Viana, Richard Hemmi Valente, Cíntia Scucuglia Heluany, Andreia Souza-Imberg, Milene Schmidt Luna, Jonas Perales, Norma Yamanouye
Primary culture of snake venom gland secretory cells could be a good model to study the mechanism(s) of toxin(s) production. These cells can produce and secrete venom to the medium with a hemorrhagic activity comparable to that induced by venom collected from snakes. Production of new venom is triggered by the sympathetic outflow, through the release of noradrenaline, but the importance of this neurotransmitter on toxin synthesis has not been addressed. This work led to the identification and comparison of the toxin panel produced by cultured secretory cells, during a 12-day time-course analysis, as well as to the effects of noradrenaline on the process...
April 13, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28412221/opportunities-for-women-in-sport-in-brazil-expectations-after-rio-2016
#20
EDITORIAL
Luciana D Mendonça, Natália F N Bittencourt, Giulianne Trevisan
No abstract text is available yet for this article.
January 21, 2017: Physical Therapy in Sport
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