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https://www.readbyqxmd.com/read/28208717/final-demonstration-of-the-co-identity-of-lipiarmycin-a3-and-tiacumicin-b-fidaxomicin-through-single-crystal-x-ray-analysis
#1
Stefano Serra, Luciana Malpezzi, Angelo Bedeschi, Claudio Fuganti, Piera Fonte
Lipiarmycin A3 and tiacumicin B possess the same chemical structure and have been considered identical till recently, when some authors have suggested the possibility of a minor difference between the chemical structures of the two antibiotics. In this work we performed a comparative X-ray analysis of lipiarmycin A3 and tiacumicin B. Although the commercial samples of the aforementioned compounds crystallize into two different crystal systems-evidently due to the different crystallization conditions-their chemical structures are identical...
February 8, 2017: Antibiotics
https://www.readbyqxmd.com/read/28207016/cardiofaciocutaneous-syndrome-and-the-dermatologist-s-contribution-to-diagnosis
#2
Vanessa Barreto Rocha, Rafael de Abreu Moraes, Luciana Baptista Pereira
No abstract text is available yet for this article.
January 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28201585/patterns-and-processes-of-mycobacterium-bovis-evolution-revealed-by-phylogenomic-analyses
#3
José S L Patané, Joaquim Martins, Ana Beatriz Castelão, Christiane Nishibe, Luciana Montera, Fabiana Bigi, Martin J Zumárraga, Angel A Cataldi, Antônio Fonseca Junior, Eliana Roxo, Ana Luiza, A R Osório, Kláudia S Jorge Ufms, Tyler C Thacker, Nalvo F Almeida, Flabio R Araújo, João C Setubal
No abstract text is available yet for this article.
February 13, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28198960/quality-of-life-of-patients-with-graft-versus-host-disease-gvhd-post-hematopoietic-stem-cell-transplantation
#4
Sibéli de Fátima Ferraz Simão Proença, Celina Mattos Machado, Raquel de Castro Figueiredo Pereira Coelho, Leila Maria Mansano Sarquis, Paulo Ricardo Bittencourt Guimarães, Luciana Puchalski Kalinke
OBJECTIVE: Assessing the quality of life of adult patients with hematological cancer in the 100 days after transplantation of hematopoietic stem cells and verifying whether the variable graft-versus-host disease (GvHD) is predictive of worse results. METHOD: An observational correlational and quantitative study with 36 adult participants diagnosed with hematologic cancer who underwent hematopoietic stem cell transplantation from September 2013 to June 2015. RESULT: The mean age was 37 years, 52...
November 2016: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28198949/influence-of-the-presence-of-temporomandibular-disorders-on-postural-balance-in-the-elderly
#5
Paula Vanessa Pedron Oltramari-Navarro, Marjorie Takei Yoshie, Rubens Alexandre da Silva, Ana Cláudia de Castro Ferreira Conti, Ricardo de Lima Navarro, Luciana Lozza do Moraes Marchiori, Karen Barros Parron Fernandes
Purpose: To investigate the influence of the presence of Temporomandibular Disorders (TMD) on postural balance in elderly individuals. Methods: The study sample consisted of 150 elderly: 103 women (67.7±5.0 years) and 47 men (69.3±5.5 years). Evaluation of the presence and severity of TMD included an anamnesis questionnaire, an evaluation of the temporomandibular joint (TMJ), and a muscular examination, which allowed the division of the elderly into 2 groups: G1 (experimental, n=95), with TMD; G2 (control, n=55), without TMD...
February 9, 2017: CoDAS
https://www.readbyqxmd.com/read/28197292/chlorthalidone-plus-amiloride-reduces-the-central-systolic-blood-pressure-in-stage-1-hypertension-patients
#6
Leticia Aparecida Barufi Fernandes, Elizabeth do Espirito Santo Cestario, Luciana Neves Cosenso-Martin, Jose Fernando Vilela-Martin, Juan Carlos Yugar-Toledo, Flavio Danni Fuchs
BACKGROUND: Hypertension reduction strategies use blood pressure in the brachial artery as the primary endpoint. Individuals who achieve the target blood pressure reduction with antihypertensive treatment have residual cardiovascular risk attributed to the difference in pressure between the aorta and brachial artery. Antihypertensive treatment affects the intrinsic properties of the vascular wall and arterial stiffness markers and consequently the central pressure. Recent publications stress the importance of adequate control of the central compared to peripheral blood pressure...
December 2016: Cardiology Research
https://www.readbyqxmd.com/read/28196934/mortality-of-adult-critically-ill-subjects-with-cancer
#7
Regis Goulart Rosa, Tulio Frederico Tonietto, Bruno Achutti Duso, Juçara Gasparetto Maccari, Roselaine Pinheiro de Oliveira, William Rutzen, Laura Madeira, Aline Ascoli, Rachel Hessler, Paola Morandi, Ricardo Viegas Cremonese, Felippe Leopoldo Dexheimer Neto, Luciana Tagliari, Patrícia de Campos Balzano, José Hervê Diel Barth, Cassiano Teixeira
BACKGROUND: Cancer patients may require intensive care support for postoperative care, complications associated with underlying malignancy, or toxicities related to cancer therapy. The higher mortality rates found in this population than in the population of ICU patients without cancer may be attributable to confounding due to a higher prevalence of multiple organic dysfunctions at ICU admission in patients with malignancy; however, data regarding this hypothesis are scarce. Accordingly, we performed the present study to compare the crude and propensity score-matched mortality rates between adult subjects with and without cancer admitted to a mixed medical-surgical ICU...
February 14, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28194646/nanoemulsion-thermoreversible-pluronic-f127-based-hydrogel-containing-hyptis-pectinata-lamiaceae-leaf-essential-oil-produced-a-lasting-anti-hyperalgesic-effect-in-chronic-noninflammatory-widespread-pain-in-mice
#8
Lucindo J Quintans-Júnior, Renan G Brito, Jullyana S S Quintans, Priscila L Santos, Zaine T Camargo, Péricles A Barreto, Maria F Arrigoni-Blank, Waldecy Lucca-Júnior, Luciana Scotti, Marcus T Scotti, Sandra J Kolker, Kathleen A Sluka
We evaluated if a nanostructured thermoreversible Pluronic F127-based hydrogel incorporated with Hyptis pectinata leaf essential oil (NE-EOH) produces a long-lasting anti-hyperalgesic effect on chronic muscle pain in an animal model. We induced chronic muscle pain by injecting the gastrocnemius with saline injections. Paw and muscle withdrawal thresholds and motor performance were evaluated after treatment and compared with morphine, diazepam, or vehicle. Naloxone and methysergide administration tested the involvement of opioid and serotonin receptors, respectively...
February 13, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28194383/clinical-evaluation-of-arthroscopic-treatment-of-shoulder-adhesive-capsulitis
#9
Alberto Naoki Miyazaki, Pedro Doneux Santos, Luciana Andrade Silva, Guilherme do Val Sella, Leonardo Carrenho, Sergio Luiz Checchia
OBJECTIVE: To evaluate the results of arthroscopic releases performed in patients with adhesive capsulitis refractory to conservative treatment. METHODS: This was a retrospective study, conducted between 1996 and 2012, which included 56 shoulders (52 patients) that underwent surgery; 38 were female, and 28 had the dominant side affected. The mean age was 51 (29-73) years. The mean follow-up was 65 (12-168) months and the mean preoperative time was 8.9 (2-24) months...
January 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28194228/guidelines-for-the-management-of-neuroendocrine-tumours-by-the-brazilian-gastrointestinal-tumour-group
#10
Rachel P Riechelmann, Rui F Weschenfelder, Frederico P Costa, Aline Chaves Andrade, Alessandro Bersch Osvaldt, Ana Rosa P Quidute, Allan Dos Santos, Ana Amélia O Hoff, Brenda Gumz, Carlos Buchpiguel, Bruno S Vilhena Pereira, Delmar Muniz Lourenço Junior, Duilio Reis da Rocha Filho, Eduardo Antunes Fonseca, Eduardo Linhares Riello Mello, Fabio Ferrari Makdissi, Fabio Luiz Waechter, Francisco Cesar Carnevale, George B Coura-Filho, Gustavo Andrade de Paulo, Gustavo Colagiovanni Girotto, João Evangelista Bezerra Neto, João Glasberg, Jose Claudio Casali-da-Rocha, Juliana Florinda M Rego, Luciana Rodrigues de Meirelles, Ludhmila Hajjar, Marcos Menezes, Marcello D Bronstein, Marcelo Tatit Sapienza, Maria Candida Barisson Villares Fragoso, Maria Adelaide Albergaria Pereira, Milton Barros, Nora Manoukian Forones, Paulo Cezar Galvão do Amaral, Raphael Salles Scortegagna de Medeiros, Raphael L C Araujo, Regis Otaviano França Bezerra, Renata D'Alpino Peixoto, Samuel Aguiar, Ulysses Ribeiro, Tulio Pfiffer, Paulo M Hoff, Anelisa K Coutinho
Neuroendocrine tumours are a heterogeneous group of diseases with a significant variety of diagnostic tests and treatment modalities. Guidelines were developed by North American and European groups to recommend their best management. However, local particularities and relativisms found worldwide led us to create Brazilian guidelines. Our consensus considered the best feasible strategies in an environment involving more limited resources. We believe that our recommendations may be extended to other countries with similar economic standards...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28194145/potential-use-of-alginate-based-carriers-as-antifungal-delivery-system
#11
REVIEW
Cristina de Castro Spadari, Luciana B Lopes, Kelly Ishida
Fungal infections have become a major public health problem, growing in number and severity in recent decades due to an increase of immunocompromised patients. The use of therapeutic agents available to treat these fungal infections is limited by their toxicity, low bioavailability, antifungal resistance, and high cost of treatment. Thus, it becomes extremely important to search for new therapeutic options. The use of polymeric systems as drug carriers has emerged as a promising alternative to conventional formulations for antifungals...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28193029/sex-determination-based-on-raman-spectroscopy-of-saliva-traces-for-forensic-purposes
#12
Claire K Muro, Luciana de Souza Fernandes, Igor K Lednev
The forensic analysis of body fluids has made great strides in recent years. Body fluids can easily be identified, and DNA analysis can be used to link a stain found at a crime scene to a specific person. When no reference DNA profile is available and the recovered DNA does not yield a match in a database, it would be incredibly useful if the evidence could still provide investigators with useful information. Biocatalytic and immunoassays can be used to determine a donor's sex, race, and other phenotypic characteristics...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28192885/polyphenols-rich-passiflora-leschenaultii-leaves-modulating-farnesoid-x-receptor-and-pregnane-x-receptor-against-paracetamol-induced-hepatotoxicity-in-rats
#13
Saravanan Shanmugam, Dhivya Sivaraj, Bruno Dos Santos Lima, Paula Dos Passos Menezes, Yasmim Maria Barbosa Gomes de Carvalho, Adriano Antunes de Souza Araújo, Narendra Narain, Mairim Russo Serafini, Lucindo José Quintans Júnior, Luciana Scotti, Marcus Tulius Scotti, Thangaraj Parimelazhagan
The hepatoprotective effect of P. leschenaultii. (DC) leaves was investigated in rats under paracetamol induced oxidative stress. Leaf acetone extract (200 and 400mg/kg) were administered daily via gavage for 14days before paracetamol (2000mg/kg, p.o.) treatment. After the experiment, the levels of serum biochemical parameters and enzymatic antioxidant levels were determined. Furthermore, liver tissues were analyzed histopathologically. Additionally, the molecular docking studies of the identified compounds against PXR and FXR proteins were also performed...
February 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28192796/analysis-of-the-prpf31-gene-in-spanish-autosomal-dominant-retinitis-pigmentosa-patients-a-novel-genomic-rearrangement
#14
Inmaculada Martin-Merida, Rocio Sanchez-Alcudia, Patricia Fernandez-San Jose, Fiona Blanco-Kelly, Raquel Perez-Carro, Luciana Rodriguez-Jacy da Silva, Berta Almoguera, Blanca Garcia-Sandoval, Maria Isabel Lopez-Molina, Almudena Avila-Fernandez, Miguel Carballo, Marta Corton, Carmen Ayuso
Purpose: The aim was to determine the prevalence of PRPF31 mutations in a cohort of Spanish autosomal dominant retinitis pigmentosa (adRP) families to deepen knowledge of the pathogenic mechanisms underlying the disease and to assess genotype-phenotype correlations. Methods: A cohort of 211 adRP patients was screened for variants in PRPF31 by using a combined strategy comprising next-generation sequencing approaches and copy-number variation (CNV) analysis. Quantitative RT-PCR and CNV analysis of the regulatory MSR1 element were also performed to assess PRPF31 gene expression...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28192178/identification-and-characterization-of-the-expression-profile-of-the-micrornas-in-the-amazon-species-colossoma-macropomum-by-next-generation-sequencing
#15
Fátima Gomes, Luciana Watanabe, Sérgio Nozawa, Layanna Oliveira, Jedson Cardoso, João Vianez, Márcio Nunes, Horacio Schneider, Iracilda Sampaio
Colossoma macropomum is a resistant species native of Amazonas and Orinoco river basins. It is regarded as the second largest finfish of Solimões and Amazon rivers, representing a major fishery resource in Amazonas and an important species in tropical aquaculture. MicroRNAs are non-coding endogenous riboregulators of nearly 22 nucleotides that play a key role in post-transcriptional gene regulation of several organisms. We analyzed samples of liver and skin from specimens of C. macropomum using next generation sequencing...
February 10, 2017: Genomics
https://www.readbyqxmd.com/read/28191971/cultures-of-the-marine-bacterium-pseudovibrio-denitrificans-ab134-produce-bromotyrosine-derived-alkaloids-previously-only-isolated-from-marine-sponges
#16
Karen J Nicacio, Laura P Ióca, Adriana M Fróes, Luciana Leomil, Luciana R Appolinario, Christiane C Thompson, Fabiano L Thompson, Antonio G Ferreira, David E Williams, Raymond J Andersen, Alessandra S Eustaquio, Roberto G S Berlinck
Herein we report the isolation and spectroscopic identification of fistularin-3 (1), 11-hydroxyaerothionin (2), and verongidoic acid (3), as well as the UPLC-HRMS detection of aerothionin (4), homopurpuroceratic acid B (5), purealidin L (6), and aplysinamisine II (7), from cultures of the marine bacterium Pseudovibrio denitrificans Ab134, isolated from tissues of the marine sponge Arenosclera brasiliensis. These results unambiguously demonstrate for the first time that bromotyrosine-derived alkaloids that were previously isolated only from Verongida sponges can be biosynthesized by a marine bacterium...
February 13, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28191891/mutations-in-donson-disrupt-replication-fork-stability-and-cause-microcephalic-dwarfism
#17
John J Reynolds, Louise S Bicknell, Paula Carroll, Martin R Higgs, Ranad Shaheen, Jennie E Murray, Dimitrios K Papadopoulos, Andrea Leitch, Olga Murina, Žygimantė Tarnauskaitė, Sarah R Wessel, Anastasia Zlatanou, Audrey Vernet, Alex von Kriegsheim, Rachel M A Mottram, Clare V Logan, Hannah Bye, Yun Li, Alexander Brean, Sateesh Maddirevula, Rachel C Challis, Kassiani Skouloudaki, Agaadir Almoisheer, Hessa S Alsaif, Ariella Amar, Natalie J Prescott, Michael B Bober, Angela Duker, Eissa Faqeih, Mohammed Zain Seidahmed, Saeed Al Tala, Abdulrahman Alswaid, Saleem Ahmed, Jumana Yousuf Al-Aama, Janine Altmüller, Mohammed Al Balwi, Angela F Brady, Luciana Chessa, Helen Cox, Rita Fischetto, Raoul Heller, Bertram D Henderson, Emma Hobson, Peter Nürnberg, E Ferda Percin, Angela Peron, Luigina Spaccini, Alan J Quigley, Seema Thakur, Carol A Wise, Grace Yoon, Maha Alnemer, Pavel Tomancak, Gökhan Yigit, A Malcolm R Taylor, Martin A M Reijns, Michael A Simpson, David Cortez, Fowzan S Alkuraya, Christopher G Mathew, Andrew P Jackson, Grant S Stewart
To ensure efficient genome duplication, cells have evolved numerous factors that promote unperturbed DNA replication and protect, repair and restart damaged forks. Here we identify downstream neighbor of SON (DONSON) as a novel fork protection factor and report biallelic DONSON mutations in 29 individuals with microcephalic dwarfism. We demonstrate that DONSON is a replisome component that stabilizes forks during genome replication. Loss of DONSON leads to severe replication-associated DNA damage arising from nucleolytic cleavage of stalled replication forks...
February 13, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28188348/graphene-oxide-fe3o4-as-sorbent-for-magnetic-solid-phase-extraction-coupled-with-liquid-chromatography-to-determine-2-4-6-trinitrotoluene-in-water-samples
#18
Luciana Costa Dos Reis, Lorena Vidal, Antonio Canals
A fast, simple, economical, and environmentally friendly magnetic solid-phase extraction (MSPE) procedure has been developed to preconcentrate 2,4,6-trinitrotoluene (TNT) from water samples prior to determination by liquid chromatography-UV-Vis employing graphene oxide/Fe3O4 nanocomposite as sorbent. The nanocomposite synthesis was investigated, and the MSPE was optimized by a multivariate approach. The optimum MSPE conditions were 40 mg of nanocomposite, 10 min of vortex extraction, 1 mL of acetonitrile as eluent, and 6 min of desorption in an ultrasonic bath...
February 10, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28187789/collaboration-between-specialties-for-respiratory-allergies-in-the-international-classification-of-diseases-icd-11
#19
Luciana Kase Tanno, Moises Calderon, Jeffrey F Linzer, Robert J G Chalmers, Pascal Demoly
BACKGROUND: The International Classification of Diseases (ICD) has been grouping the allergic and hypersensitivity disorders involving the respiratory tract under topographic distribution, regardless of the underlying mechanisms, triggers or concepts currently in use for allergic and hypersensitivity conditions. In order to strengthen awareness and deliberate the creation of the new "Allergic or hypersensitivity disorders involving the respiratory tract" section of the ICD-11, we here propose make the building process public...
February 10, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28186836/assessment-of-osteoporotic-alterations-in-type-2-diabetes-a-retrospective-study
#20
Luciana Munhoz, Arthur Rodriguez Gonzalez Cortes, Emiko Saito Arita
OBJECTIVE: To analyse the influence of type 2 diabetes on bone mineral density and panoramic radiomorphometry in postmenopausal women, comparing with results from non-diabetics postmenopausal women. METHODS: A total of 228 postmenopausal women (mean age: 59.51 ± 11.08 years) were included in this study. Demographics, T- and Z- scores from peripheral dual x-ray absorptiometry (DXA) and mandibular cortical index (MCI) from panoramic radiographs were assessed. Mean comparison between results for diabetics and non-diabetic was carried out with the student T test...
February 10, 2017: Dento Maxillo Facial Radiology
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