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Andrew A M Morris, Viktor Kožich, Saikat Santra, Generoso Andria, Tawfeg I M Ben-Omran, Anupam B Chakrapani, Ellen Crushell, Mick J Henderson, Michel Hochuli, Martina Huemer, Miriam C H Janssen, Francois Maillot, Philip D Mayne, Jenny McNulty, Tara M Morrison, Helene Ogier, Siobhan O'Sullivan, Markéta Pavlíková, Isabel Tavares de Almeida, Allyson Terry, Sufin Yap, Henk J Blom, Kimberly A Chapman
Cystathionine beta-synthase (CBS) deficiency is a rare inherited disorder in the methionine catabolic pathway, in which the impaired synthesis of cystathionine leads to accumulation of homocysteine. Patients can present to many different specialists and diagnosis is often delayed. Severely affected patients usually present in childhood with ectopia lentis, learning difficulties and skeletal abnormalities. These patients generally require treatment with a low-methionine diet and/or betaine. In contrast, mildly affected patients are likely to present as adults with thromboembolism and to respond to treatment with pyridoxine...
October 24, 2016: Journal of Inherited Metabolic Disease
Alexandre Pedro Tavares da Fonseca Magalhães, Elisabete da Conceição Pereira Ramos, Maria de Fátima Rodrigues Pereira de Pina
BACKGROUND: Proximity to urban green spaces (UGS) and open sports spaces (OSS) benefits health, promotes physical activity (PA) and sports practice (SP). OBJECTIVE: Analyse the association between PA or SP according to distances between UGS or OSS and teenagers' residences or schools. METHODS: We evaluated 1333 (53.9% girls) teenagers (13year-old) living and studying in Porto, Portugal (EPITeen cohort). PA was classified as light or moderate/vigorous...
October 24, 2016: Journal of Physical Activity & Health
Alexandre Pedro Tavares da Fonseca Magalhães, Maria de Fátima Rodrigues Pereira de Pina, Elisabete da Conceição Pereira Ramos
PURPOSE: Adolescence may be a period particularly relevant for acquisition of lifelong habits of physical activity (PA). We investigated the tracking of leisure-time PA from 13 to 17 years old and the influence of urban environment and other determinants. METHODS: As part of the EPITeen cohort (Portugal), we evaluated 969 adolescents living in the city of Porto. Participants were assembled in public and private schools at 13 years and reevaluated at 17 years. Leisure-time PA was evaluated by self-reported questionnaires...
October 19, 2016: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
Gabriela Debom, Marta Gazal, Mayara Sandrielly Pereira Soares, Carlus Augustu Tavares do Couto, Bruna Mattos, Claiton Lencina, Manuella Pinto Kaster, Gabriele Codenonzi Ghisleni, Rejane Tavares, Elizandra Braganhol, Vitor Clasen Chaves, Flávio Henrique Reginatto, Francieli Stefanello, Roselia Maria Spanevello
The aim of the present study was to evaluate the protective effects of blueberry extract on oxidative stress and inflammatory parameters in a model of mania induced by ketamine administration in rats. Male rats were pretreated with blueberry extract (200mg/kg, once a day for 14 days) lithium chloride (45mg/kg, mood stabilizer used as a positive control, twice a day for 14 days), or vehicle. Between the 8th and 14th days, rats also received an injection of ketamine (25mg/kg) or vehicle. In the 15th day, thirty minutes after ketamine administration the hyperlocomotion of the animals was assessed in the open - field apparatus...
October 18, 2016: Brain Research Bulletin
Rui Seixas, Tânia Raquel Santos, Jorge Machado, Luís Tavares, Fernando Bernardo, Teresa Semedo-Lemsaddek, Manuela Oliveira
The increase in prevalence of Salmonella 1,4,[5],12:i:- related infections over the last few years has been considered a public health issue in many European countries, especially as this serovar may be associated with tetraresistance to ampicillin, streptomycin, sulfonamides, and tetracyclines (R-type ASSuT). Salmonella 1,4,[5],12:i:- isolates (n = 187) obtained by the Portuguese National Laboratory from different sources, including human clinical cases (n = 170), veterinary (n = 10), environmental (n = 6), and food samples (n = 1), were collected from 15 districts between 2006 and 2011...
October 21, 2016: Foodborne Pathogens and Disease
Natália Helen Ferreira, Kelly Jacqueline Barbosa de Andrade, Luís Fernando Leandro, Nathália Oliveira Acésio, Suzana Amorim Mendes, Lucas Silva Cintra, Ana Helena Januário, Denise Crispim Tavares
The aim of this study was to examine the cytotoxic and genotoxic potential of a hydroethanolic extract of Schefflera vinosa (SV), a plant with schistosomicidal activity, as well as its influence on DNA damage induced by different mutagens, methyl methane sulfonate (MMS) and hydrogen peroxide (H2O2), in V79 cells and Swiss mice. Schefflera vinosa extract produced cytotoxicity at concentrations of 312.5 µg/ml or higher using the XTT cell proliferation assay kit. Treatment of V79 cell cultures with the highest SV concentration tested (150 µg/ml) significantly increased the frequency of micronuclei (MN) compared to controls...
October 21, 2016: Journal of Toxicology and Environmental Health. Part A
Vânia Sammartino Mariano, Adriana Tarlá Lorenzi, Cristovam Scapulatempo-Neto, Maíra Degiovani Stein, Julio Cesar Possati Resende, Márcio Antoniazzi, Luisa Lina Villa, José Eduardo Levi, Adhemar Longatto-Filho, José Humberto Tavares Guerreiro Fregnani
OBJECTIVE: To evaluate the reproducibility and accuracy of the HPV16/18-E6 test. METHODS: The study population was comprised of 448 women with a previously abnormal Pap who were referred to the Barretos Cancer Hospital (Brazil) for diagnosis and treatment. Two cervical samples were collected immediately before colposcopy, one for the hr-HPV-DNA test and cytology and the other for the HPV16/18-E6 test using high-affinity monoclonal antibodies (mAb). Women with a histologic diagnosis of cervical intraepithelial neoplasia grade 2 or 3 were considered to be positive cases...
2016: PloS One
Raul S Gonzalez, Sadiq M Amer, Nejib Ben Yahia, Felipe D'Almeida Costa, Manu Noatay, Jian-Hua Qiao, Flavia G Rosado, Yale Rosen, Bruno Tavares Sedassari, Rhonda K Yantiss, Jerad M Gardner
CONTEXT: -Facebook (Menlo Park, California) is one of many online sites that provide potential educational tools for pathologists. We have each founded Facebook groups dedicated to anatomic pathology, in which members can share cases, ask questions, and contribute to discussions. OBJECTIVES: -To report our experiences in founding and maintaining these Facebook groups and to characterize the contributed content. DESIGN: -We circulated a survey among the group founders, then compiled and analyzed the responses...
October 20, 2016: Archives of Pathology & Laboratory Medicine
Victor Hugo C de Albuquerque, Plácido Rogerio Pinheiro, João Paulo Papa, João Manuel R S Tavares, Ronaldo Parente de Menezes, Carlos A S Oliveira
No abstract text is available yet for this article.
2016: Computational Intelligence and Neuroscience
Daniela S Tavares, Cláudia B Lopes, Ana L Daniel-da-Silva, Carlos Vale, Tito Trindade, Maria E Pereira
Dithiocarbamate-functionalized magnetite nanoparticles (Fe3O4@SiO2/SiDTC) have been investigated as a convenient and effective sorbent for mercury removal from river, estuarine and sea waters, and their capability to decrease realistic environmental concentrations to the new environmental quality standards was evaluated. The sorption kinetics was well described by the Elovich model and the initial sorption rate was dependent of the sorbent dose. Except for river water sample, the Fe3O4@SiO2/SiDTC particles uptake 99...
October 13, 2016: Water Research
Lien M Dos Santos, Tatiane M da Silva, Juliana H Azambuja, Priscila T Ramos, Pathise S Oliveira, Elita F da Silveira, Nathalia S Pedra, Kennia Galdino, Carlus A T do Couto, Mayara S P Soares, Rejane G Tavares, Roselia M Spanevello, Francieli M Stefanello, Elizandra Braganhol
Methionine is an essential amino acid involved in critical metabolic process, and regulation of methionine flux through metabolism is important to supply this amino acid for cell needs. Elevation in plasma methionine commonly occurs due to mutations in methionine-metabolizing enzymes, such as methionine adenosyltransferase. Hypermethioninemic patients exhibit clinical manifestations, including neuronal and liver disorders involving inflammation and tissue injury, which pathophysiology is not completely established...
October 17, 2016: Molecular and Cellular Biochemistry
Andréa Marques, Ana M Rodrigues, José Carlos Romeu, Afonso Ruano, Ana Paula Barbosa, Eugénia Simões, Fernanda Águas, Helena Canhão, José Delgado Alves, Raquel Lucas, Jaime Cunha Branco, Jorge Laíns, Mário Mascarenhas, Susete Simões, Viviana Tavares, Oscar Lourenço, José António Pereira da Silva
OBJECTIVE: To establish Portuguese recommendations regarding the indication to perform DXA and to initiate medication aimed at the prevention of fragility fractures. METHODS: A multidisciplinary panel, representing the full spectrum of medical specialties and patient associations devoted to osteoporosis, as well as national experts in this field and in health economics, was gathered to developed recommendations based on available evidence and expert consensus. Recently obtained data on the Portuguese epidemiologic, economic and quality-of-life aspects of fragility fractures were used to support decisions...
October 18, 2016: Acta Reumatológica Portuguesa
Emerson Tavares de Sousa, Beatriz Feitosa da Silva, Fabiana Barros Marinho Maia, Franklin Delano Soares Forte, Fábio Correia Sampaio
BACKGROUND: The normative orthodontic treatment need, established by dental professionals during the dental appointment, becomes ineffective when it does not evaluate all the factors that influence the decision-making process, including individuals' perception and satisfaction with their dental appearance. Therefore, the purpose of this study was to investigate the perception of children and their mothers as regards orthodontic treatment need and satisfaction with dental aesthetics and test if these variables are associated with the objective orthodontic treatment needs, assessed by the Dental Aesthetic Index (DAI)...
December 2016: Progress in Orthodontics
Ana Santana, Armindo Melo, Tânia Tavares, Isabel M P L V O Ferreira
The increase of hen egg consumption demands profitable applications for eggshells, including their membranes, in order to minimize environmental and public health problems that could result from their accumulation. This work presents an innovative application for eggshell membranes to obtain an added-value food ingredient that combines maximized ACE-inhibitory and antioxidant activities. Firstly, the use of acetic acid 5% (v/v); and 3-mercaptopropionic acid 1.25 M enabled 63% recovery of eggshell membrane proteins...
October 17, 2016: Food & Function
Luciana P Tavares, Mauro M Teixeira, Cristiana C Garcia
Influenza A virus (IAV) is a relevant respiratory tract pathogen leading to a great number of deaths and hospitalizations worldwide. Secondary bacterial infections are a very common cause of IAV associated morbidity and mortality. The robust inflammatory response that follows infection is important for the control of virus proliferation but is also associated with lung damage, morbidity and death. The role of the different components of immune response underlying protection or disease during IAV infection is not completely elucidated...
October 15, 2016: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
Marcelo Simonsen, José Humberto Tavares Guerreiro Fregnani, Júlio Cesar Possati Resende, Márcio Antoniazzi, Adhemar Longatto-Filho, Cristovam Scapulatempo-Neto
OBJECTIVES: To compare the performance of two cervical collection devices (Cytobrush+Ayres spatula and Cervex-Brush® Combi) for cellular sampling, transformation zone representation and accuracy in diagnosing cervical intraepithelial neoplasia (CIN) 2+. METHODS: Cervical samples were collected from patients referred to the colposcopy unit of the Barretos Cancer Hospital between September 2013 and October 2014 using one of the two sampling devices. Additionally, colposcopy was performed with or without cervical biopsy and/or endocervical curettage...
2016: PloS One
Sandro Dutra E Silva, Aurea Marchetti Bandeira, Giovana Galvão Tavares, Luciana Murari
This article analyzes the representations of nature in the literature of Bernardo Élis based on the theoretical and methodological assumptions of environmental history. Élis was part of a group of intellectuals whose literature presented the living conditions in the frontier of Goiás and the human relationships occurring in these landscapes. In these scrublands, the dramas of their characters are mixed with the physical environment of the cerrado region in a realistic narrative denouncing the living conditions in this isolated frontier area...
October 10, 2016: História, Ciências, Saúde—Manguinhos
Naiara Stefanello, Roberta Schmatz, Luciane Belmonte Pereira, Andréia Machado Cardoso, Sabina Passamonti, Rosélia Maria Spanevello, Gustavo Thomé, Giovanna Medeiros Tavares de Oliveira, Luiza Wilges Kist, Maurício Reis Bogo, Vera Maria Morsch, Maria Rosa Chitolina Schetinger
We evaluated the effect of chlorogenic acid (CGA), caffeine (CA) and coffee (CF) on components of the purinergic system from the cerebral cortex and platelets of streptozotocin-induced diabetic rats. Animals were divided into eight groups: control animals treated with (I) water (WT), (II) CGA (5 mg/kg), (III) CA (15 mg/kg) and (IV) CF (0.5 g/kg), and diabetic animals treated with (V) WT, (VI) CGA (5 mg/kg), (VII) CA (15 mg/kg) and (VIII) CF (0.5 g/kg). Our results showed an increase (173%) in adenosine monophosphate (AMP) hydrolysis in the cerebral cortex of diabetic rats...
September 22, 2016: Journal of Nutritional Biochemistry
Luciano Tavares Angelo Cintra, Renata Oliveira Samuel, Annelise Katrine Carrara Prieto, Dóris Hissako Sumida, Eloi Dezan-Júnior, João Eduardo Gomes-Filho
OBJECTIVES: The effects of apical periodontitis (AP) and periodontal disease (PD) on organ weights in rats with diabetes mellitus (DM) were evaluated. DESIGN: Eighty male rats (Rattus norvegicus albinus, Wistar) were divided into eight groups of ten: normoglycemic (N), AP, PD, AP+PD, DM, DM+AP, DM+PD, and DM+AP+PD. DM was induced by streptozotocin; AP, by dental exposure to the oral environment; and PD, by periodontal ligature. Blood glucose concentration was measured at 0, 6, 15, and 35days; body weight, measured daily; and animals were sacrificed after 30days after induction of oral infections...
October 5, 2016: Archives of Oral Biology
Germano L D Leite, Paula D De Paulo, José C Zanuncio, Wagner De S Tavares, Anarelly C Alvarenga, Luan R Dourado, Edilson P R Bispo, Marcus A Soares
Selective agrochemicals including herbicides that do not affect non-target organisms such as natural enemies are important in the integrated pest management (IPM) programs. The aim of this study was to evaluate the herbicide toxicity, selectivity and hormesis of nicosulfuron, recommended for the corn Zea mays L. (Poaceae) crop, on 10 Trichogrammatidae (Hymenoptera) species. A female of each Trichogramma spp. or Trichogrammatoidea annulata De Santis, 1972 was individually placed in plastic test tubes (no choice) with a cardboard containing 45 flour moth Anagasta ( = Ephestia) kuehniella Zeller, 1879 (Lepidoptera: Pyralidae) eggs...
October 11, 2016: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
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