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https://www.readbyqxmd.com/read/29749459/ctrp9-ameliorates-cellular-senescence-via-pgc%C3%A2-1%C3%AE-ampk-signaling-in-mesenchymal-stem-cells
#1
Qun Li, Zhangzhang Zhu, Chengde Wang, Lin Cai, Jianglong Lu, Yongchun Wang, Jiadong Xu, Zhipeng Su, Weiming Zheng, Xianbin Chen
Stroke is the second most common cause of death worldwide, and thus, it imposes great financial burdens on both individuals and society. Mesenchymal stem cell (MSC) therapy is a promising approach for ischemic brain injury. However, MSC treatment potential is progressively reduced with age, limiting their therapeutic efficacy for brain repair post‑stroke. C1q and tumor necrosis factor‑related protein 9 (CTRP9) is a novel cytoprotective cytokine with antioxidant effects, which is highly expressed in brain tissue...
May 9, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29704818/serum-c1q-tnf-related-protein-9-is-not-related-to-nonalcoholic-fatty-liver-disease
#2
Chi Zhang, Nan Zhou, Ping Qiu, Yuming Fu, Zefa Liu, Hongxia Li, Xiangjun Yang, Lei Zhang
AIMS: C1q/TNF-related protein 9 (CTRP9) is an adipokine mainly secreted by white adipose tissue and plays protective roles in energy metabolism. However, information regarding the role of CTRP9 in nonalcoholic fatty liver disease (NAFLD) is scarce. Here we aimed to ascertain the clinical relevance between circulating CTRP9 levels and NAFLD through a cross-sectional study. METHODS: The study enrolled 82 NAFLD adults and 79 sex- and age-matched non-NAFLD controls...
April 25, 2018: Cytokine
https://www.readbyqxmd.com/read/29381773/association-of-circulating-ctrp9-with-soluble-adhesion-molecules-and-inflammatory-markers-in-patients-with-type-2-diabetes-mellitus-and-coronary-artery-disease
#3
Nariman Moradi, Reza Fadaei, Solaleh Emamgholipour, Elham Kazemian, Ghodratollah Panahi, Siamak Vahedi, Lotfolah Saed, Soudabeh Fallah
C1q/TNF-related protein 9 (CTRP9) is a paralogue of adiponectin with known favorable effects on lipid and glucose metabolism. A potential role of CTRP9 for regulation of endothelium function has been suggested by previous studies. However, no studies have examined the relation between serum CTRP9 levels and adhesion molecules in patients with type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD). The present study was conducted on 337 subjects who underwent coronary angiography and were categorized into four groups according to the presence of CAD and T2DM (control, CAD, T2DM and CAD+T2DM)...
2018: PloS One
https://www.readbyqxmd.com/read/29145717/ctrp9-regulates-growth-differentiation-and-apoptosis-in-human-keratinocytes-through-tgf%C3%AE-1-p38-dependent-pathway
#4
Tae Woo Jung, Hyung Sub Park, Geum Hee Choi, Daehwan Kim, Taeseung Lee
Impairment of wound healing is a common problem in individuals with diabetes. Adiponectin, an adipocyte-derived cytokine, has many beneficial effects on metabolic disorders such as diabetes, obesity, hypertension, and dyslipidemia. C1q/TNF-Related Protein 9 (CTRP9), the closest paralog of adiponectin, has been reported to have beneficial effects on wound healing. In the current study, we demonstrate that CTRP9 regulates growth, differentiation, and apoptosis of HaCaT human keratinocytes. We found that CTRP9 augmented expression of transforming growth factor beta 1 (TGFβ1) by transcription factor activator protein 1 (AP-1) binding activity and phosphorylation of p38 in a dose-dependent manner...
December 31, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28978553/c1q-tumor-necrosis-factor-related-protein-9-regulates-the-fate-of-implanted-mesenchymal-stem-cells-and-mobilizes-their-protective-effects-against-ischemic-heart-injury-via-multiple-novel-signaling-pathways
#5
Wenjun Yan, Yongzhen Guo, Ling Tao, Wayne Bond Lau, Lu Gan, Zheyi Yan, Rui Guo, Erhe Gao, G William Wong, Walter L Koch, Yajing Wang, Xin-Liang Ma
BACKGROUND: Cell therapy remains the most promising approach against ischemic heart injury. However, the poor survival of engrafted stem cells in the ischemic environment limits their therapeutic efficacy for cardiac repair after myocardial infarction. CTRP9 (C1q/tumor necrosis factor-related protein-9) is a novel prosurvival cardiokine with significantly downregulated expression after myocardial infarction. Here we tested a hypothesis that CTRP9 might be a cardiokine required for a healthy microenvironment promoting implanted stem cell survival and cardioprotection...
November 28, 2017: Circulation
https://www.readbyqxmd.com/read/28902432/c1q-tnf-related-protein-9-improves-the-anti-contractile-effects-of-perivascular-adipose-tissue-via-the-ampk-enos-pathway-in-diet-induced-obese-mice
#6
Fang Han, Yang Zhang, Mingxia Shao, Qingjie Mu, Xiaotong Jiao, Ningning Hou, Xiaodong Sun
The anti-contractile property of perivascular adipose tissue (PVAT) is abolished through an endothelium-dependent pathway in obesity. C1q/tumor necrosis factor-related protein (CTRP)9 improved endothelial function by promoting endothelium-dependent vasodilatation. The aims of this study were to investigate whether CTRP9 improves the anti-contractile effect of PVAT and protects against PVAT dysfunction in obese mice. The mice were treated with a high-fat diet with or without CTRP9 treatment. Thoracic aortas with or without PVAT (PVAT+ or PVAT-) were prepared, and concentration-dependent responses to phenylephrine were measured...
January 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28743061/circulating-ctrp9-levels-are-increased-in-patients-with-newly-diagnosed-type-2-diabetes-and-correlated-with-insulin-resistance
#7
Yanjun Jia, Xiaohe Luo, Ying Ji, Jingwen Xie, Han Jiang, Mao Fu, Xiaoqiang Li
AIMS: C1q/TNF-related protein-9 (CTRP9) is a novel adipokine that has been shown to promote lipid metabolism, enhance insulin sensitivity and protect against cardiovascular disease. However, previous studies in humans have produced controversial results regarding the association between CTRP9 and insulin resistance. The objective of this study was to evaluate the relationships between CTRP9 and insulin resistance in Chinese population. METHODS: Subjects with normal glucose tolerance (NGT, n=108), impaired glucose tolerance (IGT, n=92), and newly diagnosed type 2 diabetes mellitus (nT2DM, n=106) were recruited to determining the circulating CTRP9 and adiponectin levels by enzyme linked immunosorbent assay...
September 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28688765/ctrp9-regulates-hypoxia-mediated-human-pulmonary-artery-smooth-muscle-cell-proliferation-apoptosis-and-migration-via-tgf-%C3%AE-1-erk1-2-signaling-pathway
#8
Yong Xin Li, Lin Run, Tao Shi, Yong Jian Zhang
Hypoxia is an important risk factor for pulmonary arterial remodeling in pulmonary arterial hypertension (PAH). Vascular remodeling in hypoxia-induced PAH is driven by excessive proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs). The purpose of the present study was to explore the expression of CTRP9 in rats model of hypoxia-induced PAH and investigate the effects of CTRP9 on HPASMCs function in vitro and determine the underlying mechanisms. We established a rat model of hypoxic PAH, which showed a downregulation of CTRP9 expression...
September 2, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28587104/c1q-tnf-related-protein-9-ameliorates-ox-ldl-induced-endothelial-dysfunction-via-pgc-1%C3%AE-ampk-mediated-antioxidant-enzyme-induction
#9
Haijian Sun, Xuexue Zhu, Yuetao Zhou, Weiwei Cai, Liying Qiu
Oxidized low-density lipoprotein (ox-LDL) accumulation is one of the critical determinants in endothelial dysfunction in many cardiovascular diseases such as atherosclerosis. C1q/TNF-related protein 9 (CTRP9) is identified to be an adipocytokine with cardioprotective properties. However, the potential roles of CTRP9 in endothelial function remain largely elusive. In the present study, the effects of CTRP9 on the proliferation, apoptosis, migration, angiogenesis, nitric oxide (NO) production and oxidative stress in human umbilical vein endothelial cells (HUVECs) exposed to ox-LDL were investigated...
May 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28524645/c1q-tnf-related-protein-9-inhibits-the-cholesterol-induced-vascular-smooth-muscle-cell-phenotype-switch-and-cell-dysfunction-by-activating-amp-dependent-kinase
#10
Qi Liu, Hui Zhang, Jiale Lin, Ruoxi Zhang, Shuyuan Chen, Wei Liu, Meng Sun, Wenjuan Du, Jingbo Hou, Bo Yu
Vascular smooth muscle cells (VSMCs) switch to macrophage-like cells after cholesterol loading, and this change may play an important role in the progression of atherosclerosis. C1q/TNF-related protein 9 (CTRP9) is a recently discovered adipokine that has been shown to have beneficial effects on glucose metabolism and vascular function, particularly in regard to cardiovascular disease. The question of whether CTRP9 can protect VSMCs from cholesterol damage has not been addressed. In this study, the impact of CTRP9 on cholesterol-damaged VSMCs was observed...
November 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28348559/mir-31-links-lipid-metabolism-and-cell-apoptosis-in-bacteria-challenged-apostichopus-japonicus-via-targeting-ctrp9
#11
Yina Shao, Chenghua Li, Wei Xu, Pengjuan Zhang, Weiwei Zhang, Xuelin Zhao
The biological functions of microRNAs (miRNAs) have been studied in a number of eukaryotic species. Recent studies on vertebrate animals have demonstrated critical roles of miRNA in immune and metabolic activities. However, studies on the functions of miRNA in invertebrates are very limited. Here, we demonstrated that miR-31 from Apostichopus japonicus disrupts the balance of lipid metabolism, thus resulting in cell apoptosis by targeting complement C1q tumor necrosis factor-related protein 9 (AjCTRP9), a novel adipokine with pleiotropic functions in immunity and metabolism...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28298952/insights-for-oxidative-stress-and-mtor-signaling-in-myocardial-ischemia-reperfusion-injury-under-diabetes
#12
REVIEW
Dajun Zhao, Jian Yang, Lifang Yang
Diabetes mellitus (DM) displays a high morbidity. The diabetic heart is susceptible to myocardial ischemia/reperfusion (MI/R) injury. Impaired activation of prosurvival pathways, endoplasmic reticulum (ER) stress, increased basal oxidative state, and decreased antioxidant defense and autophagy may render diabetic hearts more vulnerable to MI/R injury. Oxidative stress and mTOR signaling crucially regulate cardiometabolism, affecting MI/R injury under diabetes. Producing reactive oxygen species (ROS) and reactive nitrogen species (RNS), uncoupling nitric oxide synthase (NOS), and disturbing the mitochondrial quality control may be three major mechanisms of oxidative stress...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28283578/molecular-identification-and-functional-analysis-of-ctrp9-in-epinephelus-coioides
#13
Guokun Yang, Chaobin Qin, Bin Wang, Jirong Jia, Xi Yuan, Caiyun Sun, Wensheng Li
CTRP9 is a member of the C1q/TNF-related protein (CTRP) superfamily and has been studied in mammals, whereas the comparative studies of CTRP9 in non-mammalian species are still absent. In this study, ctrp9 was isolated and characterized from the orange-spotted grouper ( Epinephelus coioides ). The full-length cDNA of ctrp9 was 1378 bp in size with an ORF (open reading frame) of 1020 bp that encodes a 339 amino acid pre-pro hormone. The mRNA expression of ctrp9 showed a rather high level in the kidney and brain, but a low level in other tissues...
May 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28207876/circulating-c1q-complement-tnf-related-protein-ctrp-1-ctrp9-ctrp12-and-ctrp13-concentrations-in-type-2-diabetes-mellitus-in-vivo-regulation-by-glucose
#14
COMPARATIVE STUDY
Bo Bai, Bo Ban, Zunjing Liu, Man Man Zhang, Bee Kang Tan, Jing Chen
OBJECTIVES: The C1q complement/TNF-related protein (CTRP) superfamily, which includes the adipokine adiponectin, has been shown in animal models to have positive metabolic and cardiovascular effects. We sought to investigate circulating CTRP1, CTRP9, CTRP12 and CTRP13 concentrations in persons with type 2 diabetes mellitus (T2DM), with age and BMI matched controls, and to examine the effects of a 2 hour 75g oral glucose tolerance test (OGTT) on serum CTRP1, CTRP9, CTRP12 and CTRP13 levels in persons with T2DM...
2017: PloS One
https://www.readbyqxmd.com/read/27821723/c1q-tnf-related-protein-9-promotes-cardiac-hypertrophy-and-failure
#15
Mahesh Appari, Astrid Breitbart, Florian Brandes, Malgorzata Szaroszyk, Natali Froese, Mortimer Korf-Klingebiel, Mona Malek Mohammadi, Andrea Grund, Gesine M Scharf, Honghui Wang, Carolin Zwadlo, Daniela Fraccarollo, Ulrike Schrameck, Mona Nemer, G William Wong, Hugo A Katus, Kai C Wollert, Oliver J Müller, Johann Bauersachs, Joerg Heineke
RATIONALE: Myocardial endothelial cells promote cardiomyocyte hypertrophy, possibly through the release of growth factors. The identity of these factors, however, remains largely unknown, and we hypothesized here that the secreted CTRP9 (C1q-tumor necrosis factor-related protein-9) might act as endothelial-derived protein to modulate heart remodeling in response to pressure overload. OBJECTIVE: To examine the source of cardiac CTRP9 and its function during pressure overload...
January 6, 2017: Circulation Research
https://www.readbyqxmd.com/read/27795806/c1q-tnf-related-protein-9-protects-diabetic-rat-heart-against-ischemia-reperfusion-injury-role-of-endoplasmic-reticulum-stress
#16
Sanxing Bai, Liang Cheng, Yang Yang, Chongxi Fan, Dajun Zhao, Zhigang Qin, Xiao Feng, Lin Zhao, Jipeng Ma, Xiaowu Wang, Jian Yang, Xuezeng Xu, Dinghua Yi, Wei Yi
As a newly identified adiponectin paralog, C1q/TNF-related protein 9 (CTRP9) reduces myocardial ischemia reperfusion (IR) injury through partially understood mechanisms. In the present study, we sought to identify the role of endoplasmic reticulum stress (ERS) in CTRP9 induced cardioprotection in diabetic heart. Isolated hearts from high-fat-diet (HFD) induced type 2 diabetic Sprague-Dawley rats were subjected to ex vivo IR protocol via a Langendorff apparatus at the presence of globular CTRP9. CTRP9 significantly improved post-IR heart function and reduced cardiac infarction, cardiomyocytes apoptosis, Caspase-3, Caspase-9, Caspase-12, TNF-α expression, and lactate dehydrogenase activity...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27771341/identification-and-characteristic-of-three-members-of-the-c1q-tnf-related-proteins-ctrps-superfamily-in-eudontomyzon-morii
#17
Liyong Chen, Fenfang Wu, Shengjian Yuan, Bo Feng
C1q is the target recognition protein of the classical complement pathway and a major connecting link between innate and acquired immunity. C1q and the multifunctional tumor necrosis factor (TNF) ligand family is of similar crystal structures, are designated the C1q/TNF-related proteins (CTRPs) superfamily. They are involved in processes as diverse as host defense, inflammation, apoptosis, autoimmunity, cell differentiation, organogenesis, hibernation and insulinresistant obesity. In this study, three members of the CTRPs superfamily were isolated and characterized in Yalu River lampreys (Eudontomyzon morii), and are respectively named LaC1qC, LaCTRP1, LaCTRP9...
December 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27743997/a-brief-glimpse-at-ctrp3-and-ctrp9-in-lipid-metabolism-and-cardiovascular-protection
#18
REVIEW
Yang Yang, Yue Li, Zhiqiang Ma, Shuai Jiang, Chongxi Fan, Wei Hu, Dongjin Wang, Shouyin Di, Yang Sun, Wei Yi
Adipose tissue is now known to express and secrete numerous adipokines that not only regulate lipid metabolism but also function in a wide array of physiological or pathological processes. C1q tumor necrosis factor-related protein 3 (CTRP3, also known as CORS26/cartducin) and CTRP9, novel members of the adipokine family, have intersecting functions in the regulation of lipid metabolism and contribute to cardiovascular protection. Here, we focus on the novel advances concerning the roles of CTRP3 and CTRP9 in these processes and review the general mechanisms...
October 2016: Progress in Lipid Research
https://www.readbyqxmd.com/read/27349872/ctrp9-induces-mitochondrial-biogenesis-and-protects-high-glucose-induced-endothelial-oxidative-damage-via-adipor1-sirt1-pgc-1%C3%AE-activation
#19
Liang Cheng, Bin Li, Xu Chen, Jie Su, Hongbing Wang, Shiqiang Yu, Qijun Zheng
Vascular lesions caused by endothelial dysfunction are the most common and serious complication of diabetes. The vasoactive potency of CTRP9 has been reported in our previous study via nitric oxide (NO) production. However, the effect of CTRP9 on vascular endothelial cells remains unknown. This study aimed to investigate the protection role of CTRP9 in the primary aortic vascular endothelial cells and HAECs under high-glucose condition. We found that the aortic vascular endothelial cells isolated from mice fed with a high fat diet generated more ROS production than normal cells, along with decreased mitochondrial biogenesis, which was also found in HAECs treated with high glucose...
September 2, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27188183/globular-ctrp9-inhibits-oxldl-induced-inflammatory-response-in-raw-264-7-macrophages-via-ampk-activation
#20
Peng Zhang, Chengmin Huang, Jun Li, Tingting Li, Haipeng Guo, Tianjiao Liu, Na Li, Qing Zhu, Yuan Guo
C1q-TNF-related protein-9 (CTRP9) is increasingly recognized as a promising cardioprotective adipocytokine, which regulates biological processes like vascular relaxation, proliferation, apoptosis, and inflammation. We recently showed that CTRP9 enhanced carotid plaque stability by reducing pro-inflammatory cytokines in macrophages. However, the underlying molecular mechanism of CTRP9 on anti-inflammatory response in macrophages still remains unclear. We demonstrated that globular CTRP9 (gCTRP9) significantly reduced oxidized low-density lipoprotein (oxLDL)-induced tumor necrosis factor alpha and monocyte chemoattractant protein 1 expression by suppressing nuclear factor-κB phosphorylation and nuclear translocation in RAW 264...
June 2016: Molecular and Cellular Biochemistry
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