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Yang Yang, Yue Li, Zhiqiang Ma, Shuai Jiang, Chongxi Fan, Wei Hu, Dongjin Wang, Shouyin Di, Yang Sun, Wei Yi
Adipose tissue is now known to express and secrete numerous adipokines that not only regulate lipid metabolism but also function in a wide array of physiological or pathological processes. C1q tumor necrosis factor-related protein 3 (CTRP3, also known as CORS26/cartducin) and CTRP9, novel members of the adipokine family, have intersecting functions in the regulation of lipid metabolism and contribute to cardiovascular protection. Here, we focus on the novel advances concerning the roles of CTRP3 and CTRP9 in these processes and review the general mechanisms...
October 12, 2016: Progress in Lipid Research
Liang Cheng, Bin Li, Xu Chen, Jie Su, Hongbing Wang, Shiqiang Yu, Qijun Zheng
Vascular lesions caused by endothelial dysfunction are the most common and serious complication of diabetes. The vasoactive potency of CTRP9 has been reported in our previous study via nitric oxide (NO) production. However, the effect of CTRP9 on vascular endothelial cells remains unknown. This study aimed to investigate the protection role of CTRP9 in the primary aortic vascular endothelial cells and HAECs under high-glucose condition. We found that the aortic vascular endothelial cells isolated from mice fed with a high fat diet generated more ROS production than normal cells, along with decreased mitochondrial biogenesis, which was also found in HAECs treated with high glucose...
September 2, 2016: Biochemical and Biophysical Research Communications
Peng Zhang, Chengmin Huang, Jun Li, Tingting Li, Haipeng Guo, Tianjiao Liu, Na Li, Qing Zhu, Yuan Guo
C1q-TNF-related protein-9 (CTRP9) is increasingly recognized as a promising cardioprotective adipocytokine, which regulates biological processes like vascular relaxation, proliferation, apoptosis, and inflammation. We recently showed that CTRP9 enhanced carotid plaque stability by reducing pro-inflammatory cytokines in macrophages. However, the underlying molecular mechanism of CTRP9 on anti-inflammatory response in macrophages still remains unclear. We demonstrated that globular CTRP9 (gCTRP9) significantly reduced oxidized low-density lipoprotein (oxLDL)-induced tumor necrosis factor alpha and monocyte chemoattractant protein 1 expression by suppressing nuclear factor-κB phosphorylation and nuclear translocation in RAW 264...
June 2016: Molecular and Cellular Biochemistry
Neda Forouhi, Ahmad Saedisomeolia, Mahmoud Djalali, Mohammad Reza Eshraghian, Nava Morshedzadeh, Fateme Zabetian-Targhi, Maryam Mahmoudi
AIMS: To compare CTRP9 levels in women with Polycystic Ovary Syndrome (PCOS) and without PCOS. Furthermore, to determine the correlation between serum CTRP9 levels and some variety of anthropometric and biochemical parameters. METHODS: The study included 29 PCOS patients and 27 healthy volunteers of the same age and BMI. Body weight, height and waist circumference were assessed. Blood samples were taken for assessment of serum CTRP9 by enzyme-linked immunosorbent assay (ELISA) technique...
April 2016: Diabetes & Metabolic Syndrome
Risa M Wolf, Kimberley E Steele, Leigh A Peterson, Xiange Zeng, Andrew E Jaffe, Michael A Schweitzer, Thomas H Magnuson, G William Wong
CONTEXT: C1q/TNF-related protein-9 (CTRP9) is a novel adipokine that has beneficial metabolic and cardiovascular effects in various animal models. Alterations in circulating CTRP9 have also been observed in patients with cardiovascular disease and diabetes, but little is known about the impact of obesity and bariatric surgery on CTRP9 concentrations. OBJECTIVE: The aim of this study was to compare CTRP9 levels in obese and lean subjects and to determine whether circulating CTRP9 levels in morbidly obese patients are altered by bariatric surgery...
May 2016: Journal of Clinical Endocrinology and Metabolism
Yongxin Li, Xigang Geng, Haichen Wang, Gesheng Cheng, Suochun Xu
Endothelial dysfunction and inflammation are believed to be 2 primary instigators of pulmonary arterial hypertension (PH). C1q/TNF-related protein 9 (CTRP9) plays important roles in anti-inflammation and improvement of epithelial function. However, the role of CTRP9 in the progression of PH remains still unclear. In this study, the role and mechanism of CTRP9 in the PH progression were explored. First, serum CTRP9 contents and CTRP9 mRNA expression in the pulmonary artery epithelial cells from patients with PH were detected...
May 2016: Journal of Cardiovascular Pharmacology
Wenqing Wang, Wayne Bond Lau, Yajing Wang, Xinliang Ma, Rong Li
Platelet hyper-reactivity is a crucial cause of accelerated atherosclerosis increasing risk of thrombotic vascular events in diabetic patients. The mechanisms leading to abnormal platelet activity during diabetes are complex and not fully defined. The current study attempted to clarify the role of CTRP9, a novel adiponectin paralog, in enhanced platelet activity and determined whether CTRP9 may inhibit platelet activity. Adult male C57BL/6 J mice were randomized to receive high-fat diet (HFD) or normal diet (ND)...
2016: Cardiovascular Diabetology
T Fujita, H Watanabe, Y Murata, S Hemmi, M Yabuki, Y Fuke, A Satomura, M Soma
Adipocytokines are associated with the pathophysiology of type 2 diabetes (T2DM). We analysed the relationship between levels of the plasma C1q/tumor necrosis factor- related protein 9 (CTRP9) and other adipocytokines or the endothelial function in patients with T2DM, and analyzed their trending manner. CTRP9 was detected in plasma from 14 out of a total of 28 patients. The values were not normally distributed. In comparing between groups in which CTRP9 was or was not detected, there were statistically significant differences in the high molecular weight adiponectin (HAN) and the urinary albumin/creatinine ratio (ACR)...
December 3, 2015: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
Chang Hee Jung, Min Jung Lee, Yu Mi Kang, Yoo La Lee, So Mi Seol, Hae Kyeong Yoon, Sang-Wook Kang, Woo Je Lee, Joong-Yeol Park
Although recent studies have reported cardioprotective effects of C1q/TNF-related protein 9 (CTRP9), the closet adiponectin paralog, its role on cytokine-induced endothelial inflammation is unknown. We investigated whether CTRP9 prevented inflammatory cytokine-induced nuclear factor-kappa B (NF-κB) activation and inhibited the expression of adhesion molecules and a chemokine in the vascular endothelial cell. We used human aortic endothelial cells (HAECs) to examine the effects of CTRP9 on NF-κB activation and the expression of NF-κB-mediated genes, including intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and monocyte chemoattractant protein-1 (MCP-1)...
January 5, 2016: Molecular and Cellular Endocrinology
Jing Wang, Tao Hang, Xun-Min Cheng, De-Min Li, Qi-Gao Zhang, Li-Jun Wang, Yong-Ping Peng, Jian-Bin Gong
OBJECTIVE: To investigate the correlation of CTRP9 with coronary atherosclerosis. METHODS: Coronary angiography confirmed CAD in 241 patients (62 received CABG) and non-CAD in 121 (55 received valve replacement). RESULTS: Serum levels of LDL-C, CRP, TNF-α, IL-6, and leptin in CAD patients were significantly higher than those in non-CAD patients (P < 0.05), but APN and CTRP9 were lower (P < 0.05). Serum levels of CTRP9 and APN were negatively related to BMI, HOMA-IR, TNF-α, IL-6, and leptin but positively to HDL-C (P < 0...
2015: BioMed Research International
Tae Woo Jung, Ho Cheol Hong, Hwan-Jin Hwang, Hye Jin Yoo, Sei Hyun Baik, Kyung Mook Choi
C1q/TNF-Related Protein (CTRP) 9, the closest paralog of adiponectin, has been reported to protect against diet-induced obesity and non-alcoholic fatty liver disease (NAFLD). However, the underlying mechanism has not been fully elucidated. We explored the protective effect of CTRP9 against hepatic steatosis and apoptosis, and identified the mechanisms through autophagy and endoplasmic reticulum (ER) stress using in vitro and in vivo experiments. Treating HepG2 cells with human recombinant CTRP9 significantly ameliorated palmitate- or tunicamycin-induced dysregulation of lipid metabolism, caspase 3 activity and chromatin condensation, which lead to reduction of hepatic triglyceride (TG) accumulation...
December 5, 2015: Molecular and Cellular Endocrinology
Takahiro Kambara, Rei Shibata, Koji Ohashi, Kazuhiro Matsuo, Mizuho Hiramatsu-Ito, Takashi Enomoto, Daisuke Yuasa, Masanori Ito, Satoko Hayakawa, Hayato Ogawa, Tamar Aprahamian, Kenneth Walsh, Toyoaki Murohara, Noriyuki Ouchi
Obesity is a risk factor for cardiovascular disease. C1q/tumor necrosis factor-related protein 9 (CTRP9) is an adipokine that is downregulated by obesity. We investigated the role of CTRP9 in cardiac injury with loss-of-function genetic manipulations and defined the receptor-mediated signaling pathway downstream of this adipokine. CTRP9-knockout (CTRP9-KO) mice at the age of 12 weeks were indistinguishable from wild-type (WT) mice under basal conditions. CTRP9-KO mice had exacerbated contractile left ventricle dysfunction following intraperitoneal injection of lipopolysaccharide (LPS) compared to WT mice...
June 2015: Molecular and Cellular Biology
Yuexing Yuan, Wayne Bond Lau, Hui Su, Yang Sun, Wei Yi, Yunhui Du, Theodore Christopher, Bernard Lopez, Yajing Wang, Xin-Liang Ma
Prevalence and severity of postmyocardial infarction heart failure continually escalate in type 2 diabetes via incompletely understood mechanisms. The discovery of the cardiac secretomes, collectively known as "cardiokines", has significantly enhanced appreciation of the local microenvironment's influence on disease development. Recent studies demonstrated that C1q-TNF-related protein-9 (CTRP9), a newly discovered adiponectin (APN) paralog, is highly expressed in the heart. However, its relationship with APN (concerning diabetic cardiovascular injury in particular) remains unknown...
May 15, 2015: American Journal of Physiology. Endocrinology and Metabolism
Xia Lei, Qing Li, Susana Rodriguez, Stefanie Y Tan, Marcus M Seldin, John C McLenithan, Weiping Jia, G William Wong
Thromboxane A2, an arachidonic acid-derived eicosanoid generated by thromboxane synthase (TBXAS), plays critical roles in hemostasis and inflammation. However, the contribution of thromboxane A2 to obesity-linked metabolic dysfunction remains incompletely understood. Here, we used in vitro and mouse models to better define the role of TBXAS in metabolic homeostasis. We found that adipose expression of Tbxas and thromboxane A2 receptor (Tbxa2r) was significantly upregulated in genetic and dietary mouse models of obesity and diabetes...
May 1, 2015: American Journal of Physiology. Endocrinology and Metabolism
Jun Li, Peng Zhang, Tingting Li, Yawei Liu, Qing Zhu, Tongshuai Chen, Tianjiao Liu, Chengmin Huang, Jianning Zhang, Yun Zhang, Yuan Guo
The aim of this study was to investigate whether C1q/TNF-related protein 9 (CTRP9) could stabilize the mature plaques by targeting macrophages in the apolipoprotein E knockout (ApoE KO) mice model. In vivo, the mice were subjected to high-fat diet and constrictive collars on the right carotid artery for eight weeks, a lentiviral vectors expressing CTRP9 (LV-CTRP9) or green fluorescence protein (LV-eGFP) as a control was intravenously injected into ApoE KO mice. Delivery of LV-CTRP9 resulted in low contents of macrophages and lipids, and high contents of collagen and vascular smooth muscle cells in the carotid mature plaques...
March 20, 2015: Biochemical and Biophysical Research Communications
Chang Hee Jung, Min Jung Lee, Yu Mi Kang, Jung Eun Jang, Jaechan Leem, Yoo La Lee, So Mi Seol, Hae Kyeong Yoon, Woo Je Lee, Joong-Yeol Park
CONTEXT: Although recent animal studies have suggested that C1q/TNF-related protein-9 (CTRP9) is more likely to be involved in the regulation of vascular function, more specifically atherosclerosis, in rodents, little is known about whether serum CTRP9 level is associated with atherosclerosis in humans. OBJECTIVE: The aim of this study was to investigate whether serum CTRP9 concentration is associated with atherosclerosis by measuring brachial ankle pulse wave velocity (baPWV) in subjects with type 2 diabetes...
December 2014: Journal of Clinical Endocrinology and Metabolism
Rei Shibata, Koji Ohashi, Toyoaki Murohara, Noriyuki Ouchi
Adipose tissue functions as an endocrine organ by producing bioactive secretory proteins, also known as adipokines, that can directly act on nearby or remote organs. Most of the adipokines are upregulated by obese conditions, and typically promote obese complications. In contrast, some adipokines, such as adiponectin, CTRP9 and omentin, are downregulated in obese states. These factors exert salutary actions on obesity-linked cardiovascular disorders. In this review, we focus on the significance of adiponectin, CTRP9 and omentin as therapeutic agents for cardiovascular disease...
August 2014: Cytokine & Growth Factor Reviews
Zhikui Wei, Xia Lei, Pia S Petersen, Susan Aja, G William Wong
Transgenic overexpression of CTRP9, a secreted hormone downregulated in obesity, confers striking protection against diet-induced obesity and type 2 diabetes. However, the physiological relevance of this adiponectin-related plasma protein remains undefined. Here, we used gene targeting to establish the metabolic function of CTRP9 in a physiological context. Mice lacking CTRP9 were obese and gained significantly more body weight when fed standard laboratory chow. Increased food intake, due in part to upregulated expression of hypothalamic orexigenic neuropeptides, contributed to greater adiposity in CTRP9 knockout mice...
April 1, 2014: American Journal of Physiology. Endocrinology and Metabolism
Y-C Hwang, S Woo Oh, S-W Park, C-Y Park
BACKGROUND: C1q/TNF-Related Protein (CTRP) family members are novel adipokines that have anti-inflammatory, immunomodulatory, glucose-regulating and vascular effects. However, the metabolic effects of CTRP9 remain unclear in humans. OBJECTIVES: The aims of this study were to investigate whether serum CTRP9 concentrations are associated with glucose tolerance, metabolic parameters and abdominal fat accumulation. In addition, the authors investigated whether the aforementioned effects of CTRP9 are independent of serum adiponectin levels...
September 2014: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Yang Sun, Wei Yi, Yuexing Yuan, Wayne Bond Lau, Dinghua Yi, Xiaoliang Wang, Yajing Wang, Hui Su, Xiaoming Wang, Erhe Gao, Walter J Koch, Xin-Liang Ma
BACKGROUND: C1q/tumor necrosis factor-related protein-9 (CTRP9) is a newly identified adiponectin paralog with established metabolic regulatory properties. However, the role of CTRP9 in postmyocardial infarction remodeling remains completely unknown. This study determined whether CTRP9 may regulate cardiac remodeling after acute myocardial infarction (AMI) and elucidated the underlying mechanisms. METHODS AND RESULTS: Male adult mice were subject to AMI by left anterior descending coronary artery ligation or sham surgery and treated with saline (vehicle) or globular CTRP9 via peritoneal implant osmotic pumps for 6 weeks...
September 10, 2013: Circulation
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