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EDITORIAL
Shubhada Nagarkar
The use of Artificial Intelligence (AI) in medical science has been widely discussed and debated. Topol foresaw that AI, particularly deep learning, would be used in a variety of applications, with users ranging from specialty doctors to paramedics [1]. He discussed how deep neural networks (DNNs) of AI can help interpret medical scans, pathology slides, skin lesions, retinal images, electrocardiograms, endoscopy, faces, and vital signs. He has described its application in radiology, pathology, dermatology, ophthalmology, cardiology, mental health, and other fields [1]...
2023: Indian Journal of Medical Ethics
#22
JOURNAL ARTICLE
Karri Kaivola, Ruth Chia, Jinhui Ding, Memoona Rasheed, Masashi Fujita, Vilas Menon, Ronald L Walton, Ryan L Collins, Kimberley Billingsley, Harrison Brand, Michael Talkowski, Xuefang Zhao, Ramita Dewan, Ali Stark, Anindita Ray, Sultana Solaiman, Pilar Alvarez Jerez, Laksh Malik, Ted M Dawson, Liana S Rosenthal, Marilyn S Albert, Olga Pletnikova, Juan C Troncoso, Mario Masellis, Julia Keith, Sandra E Black, Luigi Ferrucci, Susan M Resnick, Toshiko Tanaka, Eric Topol, Ali Torkamani, Pentti Tienari, Tatiana M Foroud, Bernardino Ghetti, John E Landers, Mina Ryten, Huw R Morris, John A Hardy, Letizia Mazzini, Sandra D'Alfonso, Cristina Moglia, Andrea Calvo, Geidy E Serrano, Thomas G Beach, Tanis Ferman, Neill R Graff-Radford, Bradley F Boeve, Zbigniew K Wszolek, Dennis W Dickson, Adriano Chiò, David A Bennett, Philip L De Jager, Owen A Ross, Clifton L Dalgard, J Raphael Gibbs, Bryan J Traynor, Sonja W Scholz
We characterized the role of structural variants, a largely unexplored type of genetic variation, in two non-Alzheimer's dementias, namely Lewy body dementia (LBD) and frontotemporal dementia (FTD)/amyotrophic lateral sclerosis (ALS). To do this, we applied an advanced structural variant calling pipeline (GATK-SV) to short-read whole-genome sequence data from 5,213 European-ancestry cases and 4,132 controls. We discovered, replicated, and validated a deletion in TPCN1 as a novel risk locus for LBD and detected the known structural variants at the C9orf72 and MAPT loci as associated with FTD/ALS...
June 14, 2023: Cell Genom
#23
JOURNAL ARTICLE
Saurabh Jha, Eric J Topol
No abstract text is available yet for this article.
June 10, 2023: Lancet
#24
Eric Topol
No abstract text is available yet for this article.
June 2023: Nature
#25
JOURNAL ARTICLE
Dave Singh, Alberto Papi, Guy Brusselle, J Christian Virchow, Giorgio Walter Canonica, Eva Topole, Andrea Vele, George Georges
These post hoc analyses suggest that the Asthma Control Questionnaire and eDiary have different measurement properties, and it is therefore potentially valuable to include both in clinical trials https://bit.ly/3TIYClX.
May 2023: ERJ Open Research
#26
JOURNAL ARTICLE
Michael Hittle, William J Culpepper, Annette Langer-Gould, Ruth Ann Marrie, Gary R Cutter, Wendy E Kaye, Laurie Wagner, Barbara Topol, Nicholas G LaRocca, Lorene M Nelson, Mitchell T Wallin
IMPORTANCE: Racial, ethnic, and geographic differences in multiple sclerosis (MS) are important factors to assess when determining the disease burden and allocating health care resources. OBJECTIVE: To calculate the US prevalence of MS in Hispanic, non-Hispanic Black (hereafter referred to as Black), and non-Hispanic White individuals (hereafter referred to as White) stratified by age, sex, and region. DESIGN, SETTING, AND PARTICIPANTS: A validated algorithm was applied to private, military, and public (Medicaid and Medicare) administrative health claims data sets to identify adult cases of MS between 2008 and 2010...
May 15, 2023: JAMA Neurology
#27
Hannah E Davis, Lisa McCorkell, Julia Moore Vogel, Eric J Topol
No abstract text is available yet for this article.
June 2023: Nature Reviews. Microbiology
#28
REVIEW
Michael Moor, Oishi Banerjee, Zahra Shakeri Hossein Abad, Harlan M Krumholz, Jure Leskovec, Eric J Topol, Pranav Rajpurkar
The exceptionally rapid development of highly flexible, reusable artificial intelligence (AI) models is likely to usher in newfound capabilities in medicine. We propose a new paradigm for medical AI, which we refer to as generalist medical AI (GMAI). GMAI models will be capable of carrying out a diverse set of tasks using very little or no task-specific labelled data. Built through self-supervision on large, diverse datasets, GMAI will flexibly interpret different combinations of medical modalities, including data from imaging, electronic health records, laboratory results, genomics, graphs or medical text...
April 2023: Nature
#29
JOURNAL ARTICLE
Eva Topole, Sonia Biondaro, Isabella Montagna, Sandrine Corre, Massimo Corradi, Sanja Stanojevic, Brian Graham, Nilakash Das, Kevin Ray, Marko Topalovic
RATIONALE: Acquiring high-quality spirometry data in clinical trials is important, particularly when using forced expiratory volume in 1 s or forced vital capacity as primary end-points. In addition to quantitative criteria, the American Thoracic Society (ATS)/European Respiratory Society (ERS) standards include subjective evaluation which introduces inter-rater variability and potential mistakes. We explored the value of artificial intelligence (AI)-based software (ArtiQ.QC) to assess spirometry quality and compared it to traditional over-reading control...
January 2023: ERJ Open Research
#30
JOURNAL ARTICLE
Scott L Delp, Eric J Topol
No abstract text is available yet for this article.
January 21, 2023: Lancet
#31
REVIEW
Hannah E Davis, Lisa McCorkell, Julia Moore Vogel, Eric J Topol
Long COVID is an often debilitating illness that occurs in at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. More than 200 symptoms have been identified with impacts on multiple organ systems. At least 65 million individuals worldwide are estimated to have long COVID, with cases increasing daily. Biomedical research has made substantial progress in identifying various pathophysiological changes and risk factors and in characterizing the illness; further, similarities with other viral-onset illnesses such as myalgic encephalomyelitis/chronic fatigue syndrome and postural orthostatic tachycardia syndrome have laid the groundwork for research in the field...
March 2023: Nature Reviews. Microbiology
#32
JOURNAL ARTICLE
Alysha Bhatti, Lucy Dunn
The COVID-19 pandemic engendered an era of virtual teaching, supporting the digital aspirations outlined in The Topol Review . We recognise that to fulfil these aspirations, clinicians must be equipped with the technical skills to effectively deliver such teaching. At Kingston Hospital NHS Foundation Trust, we implemented a case-based teaching programme that improved presenters' confidence in delivering online teaching. Through our work, we offer a sustainable solution for the continued education of medical professionals while simultaneously enhancing competency in digital literacy...
November 2022: Future Healthcare Journal
#33
JOURNAL ARTICLE
Hoda S Abdel Magid, Barbara Topol, Valerie McGuire, Jessica A Hinman, Edward J Kasarskis, Lorene M Nelson
INTRODUCTION: We investigated the associations between antecedent all-cause CVD diagnoses, cause-specific CVD diagnosis, and CVD medication prescriptions with the risk of developing amyotrophic lateral sclerosis (ALS). MATERIALS AND METHODS: We conducted a population-based case-control study of U.S. Medicare enrollees from 2006 to 2013. The final sample included 3,714 incident ALS cases and 18,570 controls (matched on age, sex, enrollment length, and county). Information was collected from Medicare Parts A, B, and D administrative claims data on hypertension, ischemic heart disease, heart failure, acute myocardial infarction, atrial fibrillation, prescriptions of angiotensin-converting enzyme inhibitors, angiotensin II receptors blockers, calcium channel blockers, beta blockers, and antiarrhythmics...
December 8, 2022: Neuroepidemiology
#34
JOURNAL ARTICLE
Gastón Andrés Topol, Ines Guerrero Pestalardo, Kenneth Dean Reeves, Fernando Elias, Neven J Steinmetz, An-Lin Cheng, David Rabago
BACKGROUND: Neurocytokines may upregulate or downregulate neuropathic pain. We hypothesized that dextrose (D-glucose) injections for therapeutic purposes (dextrose prolotherapy: DPT) in painful knee osteoarthritis (KOA) would favorably affect synovial-fluid neurocytokine concentrations. METHODS: Twenty participants with grade IV symptomatic KOA received synovial-fluid aspiration followed by dextrose or simulated dextrose injections, followed by the reverse after one week...
November 14, 2022: Clinics and Practice
#35
JOURNAL ARTICLE
Gabriela Kleinerman, Saar Gross, Shira Topol, Ella Ariel, Gerry Volokh, Sivan Melloul, Shani Etty Mergy, Yaakov Malamud, Sagi Gilboa, Yoav Gal, Libby Weiss, Juergen A Richt, Nicola Decaro, Shadi Eskandar, Yarden Arieli, Efrat Gingis, Yacov Sachter, Lavie Chaim
Domestic cats are susceptible to SARS-CoV-2 infection and can transmit the virus to other felines. A high number of COVID-19 human cases within the military personnel and a high density of stray cats living close to soldiers raised the need to perform active animal surveillance. We validated a novel quantitative serological microarray for use in cats, that enables simultaneous detection of IgG and IgM responses; in addition, molecular genetic SARS-CoV-2 detection was performed. Three out of 131 cats analyzed, showed IgG antibodies against SARS-CoV-2 RBD and S2P (2...
November 3, 2022: Comparative Immunology, Microbiology and Infectious Diseases
#36
JOURNAL ARTICLE
Mehak Dhande, Larissa Myaskovsky, Andrew Althouse, Madhurmeet Singh, Raul Weiss, Alaa Shalaby, Sana M Al-Khatib, Alicia Topoll, Sandeep Jain, Samir Saba
Background: Cardiac resynchronization therapy (CRT) improves quality of life (QOL) in heart failure (HF) patients with reduced ejection fraction. Clinicians may have difficulty choosing between CRT with a pacemaker (CRT-P) or a defibrillator (CRT-D) for older patients. CRT-P devices are smaller, have more battery longevity, are less prone to erosions or recalls, and do not deliver shocks. These factors may impact patients' QOL, but data on such comparisons are lacking. Objectives: We examined the impact of CRT-P versus CRT-D on the QOL of older (≥75 years) HF patients who qualified for implantable cardioverter defibrillator therapy...
November 8, 2022: Journal of Palliative Medicine
#37
REVIEW
Amy Abernethy, Laura Adams, Meredith Barrett, Christine Bechtel, Patricia Brennan, Atul Butte, Judith Faulkner, Elaine Fontaine, Stephen Friedhoff, John Halamka, Michael Howell, Kevin Johnson, Peter Long, Deven McGraw, Redonda Miller, Peter Lee, Jonathan Perlin, Donald Rucker, Lew Sandy, Lucia Savage, Lisa Stump, Paul Tang, Eric Topol, Reed Tuckson, Kristen Valdes
No abstract text is available yet for this article.
2022: NAM perspectives
#38
JOURNAL ARTICLE
Jennifer M Radin, Giorgio Quer, Jay A Pandit, Matteo Gadaleta, Katie Baca-Motes, Edward Ramos, Erin Coughlin, Katie Quartuccio, Vik Kheterpal, Leo M Wolansky, Steven R Steinhubl, Eric J Topol
BACKGROUND: Traditional viral illness surveillance relies on in-person clinical or laboratory data, paper-based data collection, and outdated technology for data transfer and aggregation. We aimed to assess whether continuous sensor data can provide an early warning signal for COVID-19 activity as individual physiological and behavioural changes might precede symptom onset, care seeking, and diagnostic testing. METHODS: This multivariable, population-based, modelling study recruited adult (aged ≥18 years) participants living in the USA who had a smartwatch or fitness tracker on any device that connected to Apple HealthKit or Google Fit and had joined the DETECT study by downloading the MyDataHelps app...
September 22, 2022: The Lancet. Digital health
#39
JOURNAL ARTICLE
David T Jones, Jeyeon Lee, Eric J Topol
No abstract text is available yet for this article.
September 24, 2022: Lancet
#40
REVIEW
Julián N Acosta, Guido J Falcone, Pranav Rajpurkar, Eric J Topol
The increasing availability of biomedical data from large biobanks, electronic health records, medical imaging, wearable and ambient biosensors, and the lower cost of genome and microbiome sequencing have set the stage for the development of multimodal artificial intelligence solutions that capture the complexity of human health and disease. In this Review, we outline the key applications enabled, along with the technical and analytical challenges. We explore opportunities in personalized medicine, digital clinical trials, remote monitoring and care, pandemic surveillance, digital twin technology and virtual health assistants...
September 2022: Nature Medicine
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