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https://www.readbyqxmd.com/read/28432408/a-rare-anastomosis-between-the-common-hepatic-artery-and-the-superior-mesenteric-artery-a-case-report
#1
Łukasz Olewnik, Grzegorz Wysiadecki, Michał Polguj, Mirosław Topol
For decades, anastomoses between unpaired branches of the abdominal aorta have attracted the attention of anatomists, surgeons and radiologists, due to their significance in many clinical procedures. This report presents a rare anastomosis between the common hepatic artery and the superior mesenteric artery, which gave off three branches to the jejunum. The diameter of the anastomosis measured at the point of its branching off the common hepatic artery and at the level of union with the superior mesenteric artery was 4...
April 21, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28385020/ground-state-vs-excited-state-interchromophoric-interaction-topology-dependent-excimer-contribution-in-mof-photophysics
#2
Pravas Deria, Jierui Yu, Tanner Smith, Rajesh Prabhu Balaraman
Metal-organic frameworks (MOFs) define emerging materials with unique optoelectronic properties that stem from the highly organized chromophoric linkers within their frameworks. The extent of ground- and excited-state interchromophoric interaction among the π-conjugated macrocyclic linkers was studied within three tetraphenyl-pyrene (1,3,6,8-tetrakis(p-benzoicacid)pyrene; H₄TBAPy) -based MOFs: ROD-7 (In₂(OH)₂TBAPy; frz), NU-901 (scu), and NU-1000 (csq) via steady-state and time-resolved spectroscopic techniques...
April 7, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28383544/mutation-of-wif1-a-potential-novel-cause-of-a-nail-patella-like-disorder
#3
Marilyn C Jones, Sarah E Topol, Manuel Rueda, Glenn Oliveira, Tierney Phillips, Emily G Spencer, Ali Torkamani
PURPOSE: Nail-Patella syndrome is a dominantly inherited genetic disorder characterized by abnormalities of the nails, knees, elbows, and pelvis. Nail abnormalities are the most constant feature of Nail-Patella syndrome. Pathogenic mutations in a single gene, LMX1B, a mesenchymal determinant of dorsal-ventral patterning, explain approximately 95% of Nail-Patella syndrome cases. However, 5% of cases remain unexplained. METHODS: Here, we present exome sequencing and analysis of four generations of a family with a dominantly inherited Nail-Patella-like disorder (nail dysplasia with some features of Nail-Patella syndrome) who tested negative for LMX1B mutation...
April 6, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28155833/multiple-impulse-therapy-in-the-assessment-of-paraspinal-muscle-tone-in-patients-with-low-back-pain
#4
Robert Haładaj, Mirosław Topol
BACKGROUND: Back pain is quite common in contemporary society, whose expectations of an effective analgesic therapy in conservative treatment lead to a necessity of searching for new diagnostic and therapeutic methods in physiotherapy. Out of the numerous physical therapy methods, Multiple Impulse Therapy (MIT) deserves special consideration. This paper aims to present and analyse the outcomes of MIT concerning paraspinal muscle tone and pain intensity in patients with low back pain. MATERIAL AND METHODS: The study enrolled 117 patients (50 women and 67 men; average age of 45...
November 30, 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28137686/towards-a-smart-medical-home
#5
Evan D Muse, Paddy M Barrett, Steven R Steinhubl, Eric J Topol
No abstract text is available yet for this article.
January 28, 2017: Lancet
https://www.readbyqxmd.com/read/28104903/the-effectiveness-of-cervical-spondylosis-therapy-with-saunders-traction-device-and-high-intensity-laser-therapy-a-randomized-controlled-trial
#6
Robert Haładaj, Mariusz Pingot, Mirosław Topol
BACKGROUND Among all spinal therapies, treatment of the cervical segment is the most difficult. The cervical segment is particularly sensitive to injuries and pain, and it also requires special care due to its great mobility and most delicate construction. The aim of this research was to evaluate analgesic efficacy and improvement of active mobility of the cervical spine after traction therapy with the Saunders device and high-intensity laser therapy (HILT) immediately after therapy, and in short-, medium-, and long-term follow-up in patients with cervical spondylosis...
January 20, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28030677/pure-genius-the-tv-series-is-there-an-icd-10-code-for-hyperbole
#7
Eric J Topol
No abstract text is available yet for this article.
January 3, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27975060/the-epidemiological-morphological-and-clinical-aspects-of-the-cervical-ribs-in-humans
#8
REVIEW
Łukasz Spadliński, Tomasz Cecot, Agata Majos, Ludomir Stefańczyk, Wioletta Pietruszewska, Grzegorz Wysiadecki, Mirosław Topol, Michał Polguj
A familiarity with the anatomy of some types of bone anomalies is necessary for clinicians involved in many medical areas. The aim of this paper is to review the newest literature concerning the morphology, embryology, clinical image, and therapeutic methods of the cervical ribs in the humans. The incidence of cervical ribs has been found to vary from 0.58% in Malaysian population to 6.2% in Turkish population. Cervical ribs have clinical implications that are generally divided into neurological or vascular...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27941802/influence-of-donor-age-on-induced-pluripotent-stem-cells
#9
Valentina Lo Sardo, William Ferguson, Galina A Erikson, Eric J Topol, Kristin K Baldwin, Ali Torkamani
Induced pluripotent stem cells (iPSCs) are being pursued as a source of cells for autologous therapies, many of which will be aimed at aged patients. To explore the impact of age on iPSC quality, we produced iPSCs from blood cells of 16 donors aged 21-100. We find that iPSCs from older donors retain an epigenetic signature of age, which can be reduced through passaging. Clonal expansion via reprogramming also enables the discovery of somatic mutations present in individual donor cells, which are missed by bulk sequencing methods...
January 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/27898975/adapting-to-artificial-intelligence-radiologists-and-pathologists-as-information-specialists
#10
Saurabh Jha, Eric J Topol
No abstract text is available yet for this article.
December 13, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27856407/self-monitoring-utilization-patterns-among-individuals-in-an-incentivized-program-for-healthy-behaviors
#11
Ju Young Kim, Nathan E Wineinger, Michael Taitel, Jennifer M Radin, Osayi Akinbosoye, Jenny Jiang, Nima Nikzad, Gregory Orr, Eric Topol, Steve Steinhubl
BACKGROUND: The advent of digital technology has enabled individuals to track meaningful biometric data about themselves. This novel capability has spurred nontraditional health care organizations to develop systems that aid users in managing their health. One of the most prolific systems is Walgreens Balance Rewards for healthy choices (BRhc) program, an incentivized, Web-based self-monitoring program. OBJECTIVE: This study was performed to evaluate health data self-tracking characteristics of individuals enrolled in the Walgreens' BRhc program, including the impact of manual versus automatic data entries through a supported device or apps...
November 17, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27830880/a-quantitative-study-of-the-arrangement-of-the-suprascapular-nerve-and-vessels-in-the-suprascapular-notch-region-new-findings-based-on-parametric-analysis
#12
H Jezierski, G Wysiadecki, M Sibiński, A Borowski, M Podgórski, M Topol, M Polguj
BACKGROUND: When closed by the superior transverse scapular ligament (STSL), the suprascapular notch (SSN) creates an osseo-fibrous tunnel which acts as a pathway for the suprascapular nerve (SN). Anatomical variations are common in this region, and these can increase the risk of neuropathy by restricting the space for nerve passage. The aim of this study is to identify any correlation between the area reduction coefficient parameters and the SN and vessel arrangements in the SSN region...
2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27830874/renal-artery-entrapment-anatomical-risk-factors-rating
#13
A Arazińska, M Polguj, M Topol, A Wojciechowski, Ł Trębiński, L Stefańczyk
BACKGROUND: Cases of renal artery entrapment (RAE) by extrinsic compression have been infrequently reported in the literature. We aimed to describe RAE and elucidate anatomical factors that may be related to renal artery stenosis. MATERIALS AND METHODS: Two hundred and four patients' computed tomography scans made for various reasons in Radiology Department from 2011 to 2015 were retrospectively analysed and 7 cases of RAE were found. Authors studied the level of origin of renal arteries vs...
2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27813626/the-report-on-the-co-occurrence-of-two-different-rare-anatomic-variations-of-the-plantaris-muscle-tendon-on-both-sides-of-an-individual
#14
Łukasz Olewnik, Grzegorz Wysiadecki, Michał Polguj, Mirosław Topol
The plantaris muscle usually begins with a short and small muscle belly on the popliteal surface of the femur and on the knee joint capsule. It continues distally to form a long and thin tendon typically fixed to the calcaneal tuberosity. However, the course and the insertion of the plantaris muscle is variable, which may influence the development of Achilles tendinopathy. The plantaris tendon may also be used for reconstruction of tendons and ligaments, such as talofibular and calcaneofibular ligament. In literature review no data concerning the co-occurrence of anatomic variations of the plantaris muscle tendon in different individuals has been found...
November 4, 2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27752082/inhibition-of-step61-ameliorates-deficits-in-mouse-and-hipsc-based-schizophrenia-models
#15
J Xu, B J Hartley, P Kurup, A Phillips, A Topol, M Xu, C Ononenyi, E Foscue, S-M Ho, T D Baguley, N Carty, C S Barros, U Müller, S Gupta, P Gochman, J Rapoport, J A Ellman, C Pittenger, B Aronow, A C Nairn, M W Nestor, P J Lombroso, K J Brennand
The brain-specific tyrosine phosphatase, STEP (STriatal-Enriched protein tyrosine Phosphatase) is an important regulator of synaptic function. STEP normally opposes synaptic strengthening by increasing N-methyl D-aspartate glutamate receptor (NMDAR) internalization through dephosphorylation of GluN2B and inactivation of the kinases extracellular signal-regulated kinase 1/2 and Fyn. Here we show that STEP61 is elevated in the cortex in the Nrg1(+/-) knockout mouse model of schizophrenia (SZ). Genetic reduction or pharmacological inhibition of STEP prevents the loss of NMDARs from synaptic membranes and reverses behavioral deficits in Nrg1(+/-) mice...
October 18, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27751390/a-laboratory-in-your-pocket
#16
Jennifer M Radin, Eric J Topol, Kristian G Andersen, Steven R Steinhubl
No abstract text is available yet for this article.
October 15, 2016: Lancet
https://www.readbyqxmd.com/read/27727376/molecular-autopsy-for-sudden-unexpected-death
#17
LETTER
Ali Torkamani, Evan D Muse, Emily G Spencer, Manuel Rueda, Glenn N Wagner, Jonathan R Lucas, Eric J Topol
No abstract text is available yet for this article.
October 11, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27668389/gene-expression-elucidates-functional-impact-of-polygenic-risk-for-schizophrenia
#18
Menachem Fromer, Panos Roussos, Solveig K Sieberts, Jessica S Johnson, David H Kavanagh, Thanneer M Perumal, Douglas M Ruderfer, Edwin C Oh, Aaron Topol, Hardik R Shah, Lambertus L Klei, Robin Kramer, Dalila Pinto, Zeynep H Gümüş, A Ercument Cicek, Kristen K Dang, Andrew Browne, Cong Lu, Lu Xie, Ben Readhead, Eli A Stahl, Jianqiu Xiao, Mahsa Parvizi, Tymor Hamamsy, John F Fullard, Ying-Chih Wang, Milind C Mahajan, Jonathan M J Derry, Joel T Dudley, Scott E Hemby, Benjamin A Logsdon, Konrad Talbot, Towfique Raj, David A Bennett, Philip L De Jager, Jun Zhu, Bin Zhang, Patrick F Sullivan, Andrew Chess, Shaun M Purcell, Leslie A Shinobu, Lara M Mangravite, Hiroyoshi Toyoshiba, Raquel E Gur, Chang-Gyu Hahn, David A Lewis, Vahram Haroutunian, Mette A Peters, Barbara K Lipska, Joseph D Buxbaum, Eric E Schadt, Keisuke Hirai, Kathryn Roeder, Kristen J Brennand, Nicholas Katsanis, Enrico Domenici, Bernie Devlin, Pamela Sklar
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral prefrontal cortex of people with schizophrenia (N = 258) and control subjects (N = 279), creating a resource of gene expression and its genetic regulation. Using this resource, ∼20% of schizophrenia loci have variants that could contribute to altered gene expression and liability. In five loci, only a single gene was involved: FURIN, TSNARE1, CNTN4, CLCN3 or SNAP91...
November 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/27631096/low-origin-of-the-radial-artery-a-case-study-including-a-review-of-literature-and-proposal-of-an-embryological-explanation
#19
REVIEW
Grzegorz Wysiadecki, Michał Polguj, Robert Haładaj, Mirosław Topol
A low origin of the radial artery is a rare anatomical variation, with the incidence estimated at 0.2 %. This report presents a previously unrecorded case of an unusual distal origin of the radial artery, co-occurring with a double recurrent radial artery. The radial artery arose under the pronator teres muscle, 76 mm below the intercondylar line of the humerus. After emerging from under the tendon of the pronator teres muscle, the radial artery took a typical course and terminated in the deep palmar arch...
March 2017: Anatomical Science International
https://www.readbyqxmd.com/read/27598901/book-review-textbook-of-interventional-cardiology-by-eric-j-topol-paul-s-teirstein
#20
Yousif Ahmad, Prakash P Punjabi
No abstract text is available yet for this article.
October 2016: Perfusion
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