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https://www.readbyqxmd.com/read/27898975/adapting-to-artificial-intelligence-radiologists-and-pathologists-as-information-specialists
#1
Saurabh Jha, Eric J Topol
No abstract text is available yet for this article.
November 29, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27856407/self-monitoring-utilization-patterns-among-individuals-in-an-incentivized-program-for-healthy-behaviors
#2
Ju Young Kim, Nathan E Wineinger, Michael Taitel, Jennifer M Radin, Osayi Akinbosoye, Jenny Jiang, Nima Nikzad, Gregory Orr, Eric Topol, Steve Steinhubl
BACKGROUND: The advent of digital technology has enabled individuals to track meaningful biometric data about themselves. This novel capability has spurred nontraditional health care organizations to develop systems that aid users in managing their health. One of the most prolific systems is Walgreens Balance Rewards for healthy choices (BRhc) program, an incentivized, Web-based self-monitoring program. OBJECTIVE: This study was performed to evaluate health data self-tracking characteristics of individuals enrolled in the Walgreens' BRhc program, including the impact of manual versus automatic data entries through a supported device or apps...
November 17, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27830880/a-quantitative-study-of-the-arrangement-of-the-suprascapular-nerve-and-vessels-in-the-suprascapular-notch-region-new-findings-based-on-parametric-analysis
#3
Hubert Jezierski, Grzegorz Wysiadecki, Marcin Sibiński, Andrzej Borowski, Michał Podgórski, Mirosław Topol, Michał Polguj
BACKGROUND: When closed by the superior transverse scapular ligament (STSL), the suprascapular notch (SSN) creates an osseo-fibrous tunnel which acts as a pathway for the suprascapular nerve (SN). Anatomical variations are common in this region, and these can increase the risk of neuropathy by restricting the space for nerve passage. The aim of this study is to identify any correlation between the area reduction coefficient parameters and the suprascapular nerve and vessel arrangements in the suprascapular notch region...
November 10, 2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27830874/renal-artery-entrapment-anatomical-risk-factors-rating
#4
Agata Arazińska, Michał Polguj, Mirosław Topol, Andrzej Wojciechowski, Łukasz Trębiński, Ludomir Stefańczyk
BACKGROUND: Cases of renal artery entrapments by extrinsic compression have been infrequently reported in literature. We aimed to describe renal artery entrapment (RAE) and elucidate anatomical factors that may be related to renal artery stenosis. MATERIALS AND METHODS: 204 patients' CT scans from 2011 to 2015 made for various reasons in Radiology Department were retrospectively analyzed and 7 cases of renal artery entrapment were found. Authors studied the level of origin of renal arteries vs celiac trunk (CT), superior mesenteric artery (SMA) and vertebrae...
November 10, 2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27813626/the-report-on-the-co-occurrence-of-two-different-rare-anatomic-variations-of-the-plantaris-muscle-tendon-on-both-sides-of-an-individual
#5
Łukasz Olewnik, Grzegorz Wysiadecki, Michał Polguj, Mirosław Topol
The plantaris muscle usually begins with a short and small muscle belly on the popliteal surface of the femur and on the knee joint capsule. It continues distally to form a long and thin tendon typically fixed to the calcaneal tuberosity. However, the course and the insertion of the plantaris muscle is variable, which may influence the development of Achilles tendinopathy. The plantaris tendon may also be used for reconstruction of tendons and ligaments, such as talofibular and calcaneofibular ligament. In literature review no data concerning the co-occurrence of anatomic variations of the plantaris muscle tendon in different individuals has been found...
November 4, 2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27752082/inhibition-of-step61-ameliorates-deficits-in-mouse-and-hipsc-based-schizophrenia-models
#6
J Xu, B J Hartley, P Kurup, A Phillips, A Topol, M Xu, C Ononenyi, E Foscue, S-M Ho, T D Baguley, N Carty, C S Barros, U Müller, S Gupta, P Gochman, J Rapoport, J A Ellman, C Pittenger, B Aronow, A C Nairn, M W Nestor, P J Lombroso, K J Brennand
The brain-specific tyrosine phosphatase, STEP (STriatal-Enriched protein tyrosine Phosphatase) is an important regulator of synaptic function. STEP normally opposes synaptic strengthening by increasing N-methyl D-aspartate glutamate receptor (NMDAR) internalization through dephosphorylation of GluN2B and inactivation of the kinases extracellular signal-regulated kinase 1/2 and Fyn. Here we show that STEP61 is elevated in the cortex in the Nrg1(+/-) knockout mouse model of schizophrenia (SZ). Genetic reduction or pharmacological inhibition of STEP prevents the loss of NMDARs from synaptic membranes and reverses behavioral deficits in Nrg1(+/-) mice...
October 18, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27751390/a-laboratory-in-your-pocket
#7
Jennifer M Radin, Eric J Topol, Kristian G Andersen, Steven R Steinhubl
No abstract text is available yet for this article.
October 15, 2016: Lancet
https://www.readbyqxmd.com/read/27727376/molecular-autopsy-for-sudden-unexpected-death
#8
LETTER
Ali Torkamani, Evan D Muse, Emily G Spencer, Manuel Rueda, Glenn N Wagner, Jonathan R Lucas, Eric J Topol
No abstract text is available yet for this article.
October 11, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27668389/gene-expression-elucidates-functional-impact-of-polygenic-risk-for-schizophrenia
#9
Menachem Fromer, Panos Roussos, Solveig K Sieberts, Jessica S Johnson, David H Kavanagh, Thanneer M Perumal, Douglas M Ruderfer, Edwin C Oh, Aaron Topol, Hardik R Shah, Lambertus L Klei, Robin Kramer, Dalila Pinto, Zeynep H Gümüş, A Ercument Cicek, Kristen K Dang, Andrew Browne, Cong Lu, Lu Xie, Ben Readhead, Eli A Stahl, Jianqiu Xiao, Mahsa Parvizi, Tymor Hamamsy, John F Fullard, Ying-Chih Wang, Milind C Mahajan, Jonathan M J Derry, Joel T Dudley, Scott E Hemby, Benjamin A Logsdon, Konrad Talbot, Towfique Raj, David A Bennett, Philip L De Jager, Jun Zhu, Bin Zhang, Patrick F Sullivan, Andrew Chess, Shaun M Purcell, Leslie A Shinobu, Lara M Mangravite, Hiroyoshi Toyoshiba, Raquel E Gur, Chang-Gyu Hahn, David A Lewis, Vahram Haroutunian, Mette A Peters, Barbara K Lipska, Joseph D Buxbaum, Eric E Schadt, Keisuke Hirai, Kathryn Roeder, Kristen J Brennand, Nicholas Katsanis, Enrico Domenici, Bernie Devlin, Pamela Sklar
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral prefrontal cortex of people with schizophrenia (N = 258) and control subjects (N = 279), creating a resource of gene expression and its genetic regulation. Using this resource, ∼20% of schizophrenia loci have variants that could contribute to altered gene expression and liability. In five loci, only a single gene was involved: FURIN, TSNARE1, CNTN4, CLCN3 or SNAP91...
November 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/27631096/low-origin-of-the-radial-artery-a-case-study-including-a-review-of-literature-and-proposal-of-an-embryological-explanation
#10
Grzegorz Wysiadecki, Michał Polguj, Robert Haładaj, Mirosław Topol
A low origin of the radial artery is a rare anatomical variation, with the incidence estimated at 0.2 %. This report presents a previously unrecorded case of an unusual distal origin of the radial artery, co-occurring with a double recurrent radial artery. The radial artery arose under the pronator teres muscle, 76 mm below the intercondylar line of the humerus. After emerging from under the tendon of the pronator teres muscle, the radial artery took a typical course and terminated in the deep palmar arch...
September 15, 2016: Anatomical Science International
https://www.readbyqxmd.com/read/27598901/book-review-textbook-of-interventional-cardiology-by-eric-j-topol-paul-s-teirstein
#11
Yousif Ahmad, Prakash P Punjabi
No abstract text is available yet for this article.
October 2016: Perfusion
https://www.readbyqxmd.com/read/27560266/off-the-cuff-rebooting-blood-pressure-treatment
#12
Steven R Steinhubl, Evan D Muse, Paddy M Barrett, Eric J Topol
No abstract text is available yet for this article.
August 20, 2016: Lancet
https://www.readbyqxmd.com/read/27560260/digital-medicine-empowering-both-patients-and-clinicians
#13
COMMENT
Eric Topol
No abstract text is available yet for this article.
August 20, 2016: Lancet
https://www.readbyqxmd.com/read/27547580/a-framework-for-smartphone-enabled-patient-generated-health-data-analysis
#14
Shreya S Gollamudi, Eric J Topol, Nathan E Wineinger
BACKGROUND: Digital medicine and smartphone-enabled health technologies provide a novel source of human health and human biology data. However, in part due to its intricacies, few methods have been established to analyze and interpret data in this domain. We previously conducted a six-month interventional trial examining the efficacy of a comprehensive smartphone-based health monitoring program for individuals with chronic disease. This included 38 individuals with hypertension who recorded 6,290 blood pressure readings over the trial...
2016: PeerJ
https://www.readbyqxmd.com/read/27539031/suprascapular-notch-morphology-in-the-pediatric-population-a-computed-tomography-study
#15
M Podgórski, M Polguj, M Topol, A Kusak, M Łukaszewski, P Grzelak
Suprascapular notch is characterized by variable morphology. However, its development is not well studied. We hypothesize that it proceeds postnatally. Thus, the aim of this research was to characterize the morphology of the suprascapular notch in a pediatric population based on computed tomography. A retrospective analysis was performed of 291 chest computed tomography examinations of patients under 18 years old taken following other clinical indications. The inclusion criteria were as follows: both scapulae encompassed in a field of view; no artifacts; no pathologies concerning the scapulae...
August 18, 2016: Anatomical Science International
https://www.readbyqxmd.com/read/27484464/missed-opportunity-why-parents-refuse-influenza-vaccination-for-their-hospitalized-children
#16
Melissa A Cameron, David Bigos, Christopher Festa, Howard Topol, Kyung E Rhee
BACKGROUND AND OBJECTIVES: Hospitals are required to screen and administer the influenza vaccine to all admitted children unless contraindicated or refused by parents, yet vaccination rates remain low. Our goal was to examine reasons for refusal among pediatric patients admitted during influenza season. METHODS: All children age 6 months to 18 years admitted to 2 network community hospitals from October 1, 2013 to March 31, 2014, without contraindications, were offered influenza vaccination prior to discharge...
September 2016: Hospital Pediatrics
https://www.readbyqxmd.com/read/27443724/stop-the-privatization-of-health-data
#17
John T Wilbanks, Eric J Topol
No abstract text is available yet for this article.
July 20, 2016: Nature
https://www.readbyqxmd.com/read/27410924/state-of-telehealth
#18
REVIEW
E Ray Dorsey, Eric J Topol
Telehealth is the provision of health care remotely by means of a variety of telecommunication tools, including telephones, smartphones, and mobile wireless devices, with or without a video connection. Telehealth is growing rapidly and has the potential to transform the delivery of health care for..
July 14, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27353802/book-review-textbook-of-interventional-cardiology-by-eric-j-topol-paul-s-teirstein
#19
Yousif Ahmad, Prakash P Punjabi
No abstract text is available yet for this article.
June 28, 2016: Perfusion
https://www.readbyqxmd.com/read/27221803/money-back-guarantees-for-non-reproducible-results
#20
EDITORIAL
Eric J Topol
No abstract text is available yet for this article.
2016: BMJ: British Medical Journal
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