Hua Tao, Xu Zhou, Jun Chen, Haihong Zhou, Lidan Huang, Yujie Cai, Jiawu Fu, Zhou Liu, Yanyan Chen, Chaowen Sun, Bin Zhao, Wangtao Zhong, Keshen Li
Recent studies have reported patients who concurrently exhibit conditions of epilepsy and schizophrenia, indicating certain shared pathologies between them. This study aimed to investigate the genetic effects of the schizophrenia-related gene DTNBP1 in temporal lobe epilepsy (TLE). A total of 496 TLE patients and 528 healthy individuals were successfully genotyped for six DTNBP1 polymorphisms (rs760665, rs1011313, rs2619528, rs2619522, rs909706, and rs2619538), including 335 TLE patients and 325 healthy controls in cohort 1, and 161 TLE patients and 203 healthy controls in cohort 2...
2021: Frontiers in Genetics