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https://www.readbyqxmd.com/read/29791796/tracking-of-engineered-bacteria-in-vivo-using-non-standard-amino-acid-incorporation
#1
Pichet Praveschotinunt, Noemie-Manuelle Dorval Courchesne, Ilona den Hartog, Chaochen Lu, Jessica J Kim, Peter Q Nguyen, Neel S Joshi
The rapidly growing field of microbiome research presents a need for better methods of monitoring gut microbes in vivo with high spatial and temporal resolution. We report a method of tracking microbes in vivo within the gastrointestinal tract by programming them to incorporate non-standard amino acids (NSAA) and labeling them via click chemistry. Using established machinery constituting an orthogonal translation system (OTS), we engineered Escherichia coli to incorporate p-azido-L-phenylalanine (pAzF) in place of the UAG (amber) stop codon...
May 23, 2018: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29791434/food-fraud-and-the-perceived-integrity-of-european-food-imports-into-china
#2
H Kendall, P Naughton, S Kuznesof, M Raley, M Dean, B Clark, H Stolz, R Home, M Y Chan, Q Zhong, P Brereton, L J Frewer
BACKGROUND/AIMS: Persistent incidents of food fraud in China have resulted in low levels of consumer trust in the authenticity and safety of food that is domestically produced. We examined the relationship between the concerns of Chinese consumers regarding food fraud, and the role that demonstrating authenticity may play in relieving those concerns. METHODS: A two-stage mixed method design research design was adopted. First, qualitative research (focus groups n = 7) was conducted in three Chinese cities, Beijing, Guangzhou and Chengdu to explore concerns held by Chinese consumers in relation to food fraud...
2018: PloS One
https://www.readbyqxmd.com/read/29789452/circulating-metabolites-associated-with-alcohol-intake-in-the-european-prospective-investigation-into-cancer-and-nutrition-cohort
#3
Eline H van Roekel, Laura Trijsburg, Nada Assi, Marion Carayol, David Achaintre, Neil Murphy, Sabina Rinaldi, Julie A Schmidt, Magdalena Stepien, Rudolf Kaaks, Tilman Kühn, Heiner Boeing, Khalid Iqbal, Domenico Palli, Vittorio Krogh, Rosario Tumino, Fulvio Ricceri, Salvatore Panico, Petra H Peeters, Bas Bueno-de-Mesquita, Eva Ardanaz, Leila Lujan-Barroso, J Ramón Quirós, José M Huerta, Elena Molina-Portillo, Miren Dorronsoro, Konstantinos K Tsilidis, Elio Riboli, Agnetha Linn Rostgaard-Hansen, Anne Tjønneland, Kim Overvad, Elisabete Weiderpass, Marie-Christine Boutron-Ruault, Gianluca Severi, Antonia Trichopoulou, Anna Karakatsani, Anastasia Kotanidou, Anders Håkansson, Johan Malm, Matty P Weijenberg, Marc J Gunter, Mazda Jenab, Mattias Johansson, Ruth C Travis, Augustin Scalbert, Pietro Ferrari
Identifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Alcohol consumption at recruitment was self-reported through dietary questionnaires. Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQTM p180 kit)...
May 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29789149/the-expanding-role-of-murine-class-ib-mhc-in-the-development-and-activation-of-natural-killer-cells
#4
REVIEW
Katharine J Goodall, Angela Nguyen, Lucy C Sullivan, Daniel M Andrews
Major Histocompatibility Complex-I (MHC-I) molecules can be divided into class Ia and class Ib, with three distinct class Ib families found in the mouse. These families are designated as Q, T and M and are largely unexplored in terms of their immunological function. Among the class Ib MHC, H2-T23 (Qa-1b) has been a significant target for Natural Killer (NK) cell research, owing to its homology with the human class Ib human leukocyte antigen (HLA)-E. However, recent data has indicated that members of the Q and M family of class Ib MHC also play a critical role in the development and regulation NK cells...
May 19, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29788924/exploration-of-the-association-between-foxe1-gene-polymorphism-and-differentiated-thyroid-cancer-a-meta-analysis
#5
Yong-Hui Chen, Ying-Qiang Zhang
BACKGROUND: Several association analyses and linkage researches indicated that inherited genetic variations effectively influence differentiated thyroid carcinogenesis. METHODS: The results from 15 published studies on differentiated thyroid carcinoma (DTC) were combined. The genetic model included rs965513, rs944289 and rs1867277. Meta-analyses were performed and cochran's χ2 based Q-statistic and I2 test were performed to assess heterogeneity using STATA software...
May 22, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29788443/pediatric-infectious-diseases-meets-the-future
#6
Janet R Gilsdorf, Paul Spearman, Janet A Englund, Tina Q Tan, Kristina A Bryant
Pediatric infectious diseases physicians are dedicated to the diagnosis, prevention, and management of infections in children. As such, we play large, and important, roles in the clinical care of children from birth to late adolescence and in infection prevention, antimicrobial stewardship, research pertaining to infections, public health, international and global health, and advocacy for children's health. Furthermore, we are critical to the education of future physicians (in general), pediatricians, and infectious diseases doctors...
May 19, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29788434/a-novel-mouse-model-of-testicular-granulosa-cell-tumors
#7
Xin Fang, Nan Ni, Yang Gao, David F Vincent, Laurent Bartholin, Qinglei Li
STUDY QUESTION: What is the role of dysregulated transforming growth factor beta (TGFB) signaling in the development of sex cord-stromal tumors in the testis? SUMMARY ANSWER: Overactivation of TGFB signaling results in the development of testicular tumors resembling granulosa cell tumors (GrCTs). WHAT IS KNOWN ALREADY: In an earlier study, we demonstrated that constitutively active TGFB receptor 1 (TGFBR1) in ovarian somatic cells promotes the development of ovarian GrCTs...
May 21, 2018: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29786874/meta-analysis-of-the-association-of-alcohol-related-social-media-use-with-alcohol-consumption-and-alcohol-related-problems-in-adolescents-and-young-adults
#8
REVIEW
Brenda L Curtis, Samantha J Lookatch, Danielle E Ramo, James R McKay, Richard S Feinn, Henry R Kranzler
Despite the pervasive use of social media by young adults, there is comparatively little known about whether, and how, engagement in social media influences this group's drinking patterns and risk of alcohol-related problems. We examined the relations between young adults' alcohol-related social media engagement (defined as the posting, liking, commenting, and viewing of alcohol-related social media content) and their drinking behavior and problems. We conducted a systematic review and meta-analysis of studies evaluating the association of alcohol consumption and alcohol-related problems with alcohol-related social media engagement...
May 22, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29785631/eating-disorders-risk-among-medical-students-a-global-systematic-review-and-meta-analysis
#9
REVIEW
Haitham Jahrami, Mai Sater, Ahmed Abdulla, Mo'ez Al-Islam Faris, Ahmed AlAnsari
PURPOSE: Medical students appear to be a high-risk group to develop psychological problems including eating disorders (ED). The prevalence estimates of ED risk vary greatly between studies. This systematic review and meta-analysis was done to estimate the prevalence of ED risk among medical students. METHODS: An electronic search of EMBASE, MEDLINE, ProQuest and Google Scholar was conducted. Studies that reported the prevalence of ED risk among medical students and were published in English peer-reviewed journals between 1982 and 2017 were included...
May 21, 2018: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/29784421/on-line-comprehensive-two-dimensional-liquid-chromatography-tandem-mass-spectrometry-for-the-analysis-of-curcuma-kwangsiensis
#10
Weijia Zhou, Zhimou Guo, Long Yu, Han Zhou, Aijin Shen, Yan Jin, Gaowa Jin, Jingyu Yan, Fan Yang, Yanming Liu, ChaoRan Wang, JiaTao Feng, Yanfang Liu, Xinmiao Liang
A novel online comprehensive two-dimensional liquid chromatography (2DLC) coupled with quadrupole time-of-flight (Q-TOF) mass spectrometry (MS) method is developed for the analysis of Curcuma kwangsiensis (C. kwangsiensis) extract. In this system, a newly developed phenyl/tetrazole sulfoether (PTAS) bonded stationary phase was introduced to construct RPLC×RPLC combined with C18. The unique structure endowed PTAS with very different selectivity from C18, reaching a high orthogonality of 93.2%. Moreover, such a combination settled compatibility issues because of the weaker hydrophobic retaining property of PTAS, thus allowing direct interfacing in online configuration...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29783834/-application-of-next-generation-sequencing-in-clinical-microbial-research
#11
L Y Guo, Q J Li, G Liu
No abstract text is available yet for this article.
May 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29781625/vertically-emitting-indium-phosphide-nanowire-lasers
#12
Wei-Zong Xu, Fang-Fang Ren, Dimitars Jevtics, Antonio Hurtado, Li Li, Qian Gao, Jiandong Ye, Fan Wang, Benoit Guilhabert, Lan Fu, Hai Lu, Rong Zhang, Hark Hoe Tan, Martin Dawson, Chennupati Jagadish
Semiconductor nanowire (NW) lasers have attracted considerable research effort given their excellent promise for nanoscale photonic sources. However, NW lasers currently exhibit poor directionality and high threshold gain, issues critically limiting their prospects for on-chip light sources with extremely reduced footprint and efficient power consumption. Here, we propose a new design and experimentally demonstrate a vertically emitting indium phosphide (InP) NW laser structure showing high emission directionality and reduced energy requirements for operation...
May 21, 2018: Nano Letters
https://www.readbyqxmd.com/read/29780408/an-intelligent-grey-wolf-optimizer-algorithm-for-distributed-compressed-sensing
#13
Haiqiang Liu, Gang Hua, Hongsheng Yin, Yonggang Xu
Distributed Compressed Sensing (DCS) is an important research area of compressed sensing (CS). This paper aims at solving the Distributed Compressed Sensing (DCS) problem based on mixed support model. In solving this problem, the previous proposed greedy pursuit algorithms easily fall into suboptimal solutions. In this paper, an intelligent grey wolf optimizer (GWO) algorithm called DCS-GWO is proposed by combining GWO and q -thresholding algorithm. In DCS-GWO, the grey wolves' positions are initialized by using the q -thresholding algorithm and updated by using the idea of GWO...
2018: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/29775032/-research-advance-of-microrna-in-the-pathogenesis-of-chronic-rhinosinusitis
#14
REVIEW
Y Ye, Q Luo, J Q Yu, J Zhang
Chronic rhinosinusitis (CRS) is a common disease of otorhinolaryngology head and neck surgery, manifested as nasal-sinus mucosal chronic inflammation. However, the pathogenesis of CRS is not clear. There are studies found that microRNA (miRNA) involved in CRS gene regulation. In this review, we summarize the expression of miRNAs in CRS, with the in-depth study of the role of miRNAs in CRS, and will further elucidate the pathogenesis of CRS.
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29775027/-clinical-research-of-different-characteristics-of-fungal-ball-sinusitis
#15
M J Wang, B Zhou, Y C Li, S J Cui, Q Huang
Objective: The aim of this study is to investigate the clinical features of different subtypes of fungal ball sinusitis. Method: Four hundred and forty-nine cases with fungal ball rhinosinusitis (FBS) were involved in this retrospective analysis. The clinical features including symptoms, signs, and imaging scans, pathological results were all collected for each patient and the patients were classified into different subtypes according to these clinical features and the follow-up treatment. Result: In this retrospective study, 449 patients who diagnosed with fungal ball sinusitis were involved...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29771432/regulatory-mechanism-of-microrna-377-on-cdh13-expression-in-the-cell-model-of-alzheimer-s-disease
#16
F-F Liu, Z Zhang, W Chen, H-Y Gu, Q-J Yan
OBJECTIVE: To explore whether microRNA-377 could participate in the development of Alzheimer's disease (AD) by regulating CDH13. MATERIALS AND METHODS: In this research, AD model was constructed by the SH-SY5Y cells. The expression levels of microRNA-377 and CDH13 in the AD model were detected by quantitative Real-time polymerase chain reaction (qRT-PCR). The cell viability and apoptosis after knockdown of microRNA-377 and CDH13 were measured by cell counting kit-8 (CCK-8) assay and flow cytometry, respectively...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29771207/the-stopit-programme-to-reduce-bullying-and-undermining-behaviour-in-hospitals
#17
Graham Benmore, Steven Henderson, Joanna Mountfield, Brian Wink
Purpose The impact of bullying and undermining behaviours on the National Health Service on costs, patient safety and retention of staff was well understood even before the Illing report, published in 2013, that reviewed the efficacy of training interventions designed to reduce bullying and harassment in the outputs. The purpose of this paper is to provide an example of a good programme well evaluated. Design/methodology/approach The methodology follows a broad realist approach, by specifying the underlying programme assumptions and intention of the designers...
May 21, 2018: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/29769290/assessment-of-an-organ-specific-de-novo-transcriptome-of-the-nematode-trap-crop-solanum-sisymbriifolium
#18
Alexander Q Wixom, N Carol Casavant, Joseph C Kuhl, Fangming Xiao, Louise-Marie Dandurand, Allan B Caplan
Solanum sisymbriifolium , also known as "Litchi Tomato" or "Sticky Nightshade," is an undomesticated and poorly researched plant related to potato and tomato. Unlike the latter species, S. sisymbriifolium induces eggs of the cyst nematode, Globodera pallida , to hatch and migrate into its roots, but then arrests further nematode maturation. In order to provide researchers with a partial blueprint of its genetic make-up so that the mechanism of this response might be identified, we used single molecule real time (SMRT) sequencing to compile a high quality de novo transcriptome of 41,189 unigenes drawn from individually sequenced bud, root, stem, and leaf RNA populations...
May 16, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29769078/the-effect-of-diabetes-self-management-education-on-hba1c-and-quality-of-life-in-african-americans-a-systematic-review-and-meta-analysis
#19
Amy T Cunningham, Denine R Crittendon, Neva White, Geoffrey D Mills, Victor Diaz, Marianna D LaNoue
BACKGROUND: Type 2 diabetes presents a major morbidity and mortality burden in the United States. Diabetes self-management education (DSME) is an intervention associated with improved hemoglobin A1c(HbA1c) and quality of life(QOL), and is recommended for all individuals with type 2 diabetes. African-Americans have disproportionate type 2 diabetes morbidity and mortality, yet no prior meta-analyses have examined DSME outcomes exclusively in this population. This systematic review and meta-analysis examined the impact of DSME on HbA1c and QOL in African-Americans compared to usual care...
May 16, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29768657/simultaneous-quantification-of-fentanyl-sufentanil-cefazolin-doxapram-and-keto-doxapram-in-plasma-using-liquid-chromatography-tandem-mass-spectrometry
#20
Robert B Flint, Soma Bahmany, Bart C H van der Nagel, Birgit C P Koch
A simple and specific UPLC-MS/MS method was developed and validated for simultaneous quantification of fentanyl, sufentanil, cefazolin, doxapram and its active metabolite keto-doxapram. The internal standard was fentanyl-d5 for all analytes. Chromatographic separation was achieved with a reversed phase Acquity UPLC HSS T3 column with a run-time of only 5.0 minutes per injected sample. Gradient elution was performed with a mobile phase consisting of ammonium acetate, formic acid in Milli-Q ultrapure water or in methanol with a total flow rate of 0...
May 16, 2018: Biomedical Chromatography: BMC
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