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https://www.readbyqxmd.com/read/28429189/using-time-perception-to-explore-implicit-sensitivity-to-emotional-stimuli-in-autism-spectrum-disorder
#1
Catherine R G Jones, Anna Lambrechts, Sebastian B Gaigg
Establishing whether implicit responses to emotional cues are intact in autism spectrum disorder (ASD) is fundamental to ascertaining why their emotional understanding is compromised. We used a temporal bisection task to assess for responsiveness to face and wildlife images that varied in emotional salience. There were no significant differences between an adult ASD and comparison group, with both showing implicit overestimation of emotional stimuli. Further, there was no correlation between overestimation of emotional stimuli and autistic traits in undergraduate students...
April 20, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28425737/time-varying-and-time-invariant-dimensions-of-depression-in-children-and-adolescents-implications-for-cross-informant-agreement
#2
David A Cole, Joan M Martin, Farrah M Jacquez, Jane M Tram, Rachel Zelkowitz, Elizabeth A Nick, Jason D Rights
The longitudinal structure of depression in children and adolescents was examined by applying a Trait-State-Occasion structural equation model to 4 waves of self, teacher, peer, and parent reports in 2 age groups (9 to 13 and 13 to 16 years old). Analyses revealed that the depression latent variable consisted of 2 longitudinal factors: a time-invariant dimension that was completely stable over time and a time-varying dimension that was not perfectly stable over time. Different sources of information were differentially sensitive to these 2 dimensions...
April 20, 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/28421105/nitrate-a-crucial-signal-during-lateral-roots-development
#3
REVIEW
Cui-Hui Sun, Jian-Qiang Yu, Da-Gang Hu
Root plasticity is an important trait for plants to forage nutrient and adapt to survival in a complicated environment. Lateral roots (LRs) are generally more sensitive than primary roots in response to changing environmental conditions. As the main source of nitrogen for most higher plants, nitrate acting as a signal has received great attention in the regulation of LR development. In general, there are dual effects including stimulatory and inhibitory of low nitrate on LR development; while high nitrate supply has an inhibitory effect on LR development; nitrate heterogeneity also has a stimulatory effect on LR development in [Formula: see text]- rich zone...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28419447/divergence-and-evolution-of-assortative-mating-in-a-polygenic-trait-model-of-speciation-with-gene-flow
#4
Himani Sachdeva, Nicholas H Barton
Assortative mating is an important driver of speciation in populations with gene flow and is predicted to evolve under certain conditions in few-locus models. However, the evolution of assortment is less understood for mating based on quantitative traits, which are often characterized by high genetic variability and extensive linkage disequilibrium between trait loci. We explore this scenario for a two-deme model with migration, by considering a single polygenic trait subject to divergent viability selection across demes, as well as assortative mating and sexual selection within demes, and investigate how trait divergence is shaped by various evolutionary forces...
April 17, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28413201/detection-of-%C3%AE-thalassaemia-in-neonates-on-cord-blood-and-dried-blood-spot-samples-by-capillary-electrophoresis
#5
H Alauddin, M Langa, M Mohd Yusoff, R Z A Raja Sabudin, A Ithnin, N F Abdul Razak, N H Sardi, N H Hussin
INTRODUCTION: Haemoglobin Bart's (Hb Bart's) level is associated with α-thalassaemia traits in neonates, enabling early diagnosis of α-thalassaemia. The study aimed to detect and quantify the Hb Bart's using Cord Blood (CB) and CE Neonat Fast Hb (NF) progammes on fresh and dried blood spot (DBS) specimen respectively by capillary electrophoresis (CE). METHODS: Capillarys Hemoglobin (E) Kit (for CB) and Capillarys Neonat Hb Kit (for NF) were used to detect and quantify Hb Bart's by CE in fresh cord blood and dried blood spot (DBS) specimens respectively...
April 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28406955/predictive-long-range-allele-specific-mapping-of-regulatory-variants-and-target-transcripts
#6
Kibaick Lee, Seulkee Lee, Hyoeun Bang, Jung Kyoon Choi
Genome-wide association studies (GWASs) have identified a large number of noncoding associations, calling for systematic mapping to causal regulatory variants and their distal target genes. A widely used method, quantitative trait loci (QTL) mapping for chromatin or expression traits, suffers from sample-to-sample experimental variation and trans-acting or environmental effects. Instead, alleles at heterozygous loci can be compared within a sample, thereby controlling for those confounding factors. Here we introduce a method for chromatin structure-based allele-specific pairing of regulatory variants and target transcripts...
2017: PloS One
https://www.readbyqxmd.com/read/28406655/heterogeneity-in-externalizing-problems-at-age-3-association-with-age-15-biological-and-environmental-outcomes
#7
Kostas A Fanti, Eva Kimonis
Investigating heterogeneity in antisocial behavior early in life is essential for understanding the etiology, development, prognosis, and treatment of these problems. Data from the longitudinal National Institute of Child Health and Development (NICHD) study of Early Child Care were used to identify homogeneous groups of young antisocial children differentiated on externalizing problems, internalizing problems, and callous-unemotional (CU) traits using latent profile analysis (LPA). We examined how identified subgroups were differentiated on adolescent social, biological, cognitive, and environmental outcomes, controlling for dispositional and contextual antecedents during the first 2 years of life...
April 13, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28403870/noise-sensitivity-rather-than-noise-level-predicts-the-non-auditory-effects-of-noise-in-community-samples-a-population-based-survey
#8
Jangho Park, Seockhoon Chung, Jiho Lee, Joo Hyun Sung, Seung Woo Cho, Chang Sun Sim
BACKGROUND: Excessive noise affects human health and interferes with daily activities. Although environmental noise may not directly cause mental illness, it may accelerate and intensify the development of latent mental disorders. Noise sensitivity (NS) is considered a moderator of non-auditory noise effects. In the present study, we aimed to assess whether NS is associated with non-auditory effects. METHODS: We recruited a community sample of 1836 residents residing in Ulsan and Seoul, South Korea...
April 12, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28399169/a-photoperiod-responsive-protein-compendium-and-conceptual-proteome-roadmap-outline-in-maize-grown-in-growth-chambers-with-controlled-conditions
#9
You-Zhi Li, Xian-Wei Fan, Qiang Chen, Hao Zhong
Maize (Zea mays L.) is one of the major staple food crops of the world. However, high photoperiod sensitivity, especially for tropical germplasms, impedes attempts to improve maize agronomical traits by integration of tropical and temperate maize germplasms. Physiological and phenotypic responses of maize to photoperiod have widely been investigated based on multi-site field observations; however, proteome-based responsive mechanisms under controlled photoperiod regimes, nutrient and moisture soils are not yet well understood...
2017: PloS One
https://www.readbyqxmd.com/read/28397857/reproductive-stage-physiological-and-transcriptional-responses-to-salinity-stress-in-reciprocal-populations-derived-from-tolerant-horkuch-and-susceptible-ir29-rice
#10
Samsad Razzaque, Taslima Haque, Sabrina M Elias, Md Sazzadur Rahman, Sudip Biswas, Scott Schwartz, Abdelbagi M Ismail, Harkamal Walia, Thomas E Juenger, Zeba I Seraj
Global increase in salinity levels has made it imperative to identify novel sources of genetic variation for tolerance traits, especially in rice. The rice landrace Horkuch, endemic to the saline coastal area of Bangladesh, was used in this study as the source of tolerance in reciprocal crosses with the sensitive but high-yielding IR29 variety for discovering transcriptional variation associated with salt tolerance in the resulting populations. The cytoplasmic effect of the Horkuch background in leaves under stress showed functional enrichment for signal transduction, DNA-dependent regulation and transport activities...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28395158/clinical-characteristics-of-latent-classes-of-co2-hypersensitivity-in-adolescents-and-young-adults
#11
Lance M Rappaport, Christina Sheerin, Jeanne E Savage, John M Hettema, Roxann Roberson-Nay
Although breathing CO2-enriched air reliably increases anxiety, there is debate concerning the nature and specificity of CO2 hypersensitivity to panic risk and panic disorder versus anxiety disorders and related traits broadly, particularly among adolescents and emerging adults. The present study sought to clarify the association of CO2 hypersensitivity with internalizing conditions and symptoms among adolescents and young adults. Participants (N = 628) self-reported anxiety levels every 2 min while breathing air enriched to 7...
June 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28394956/-being-physically-active-modifies-the-detrimental-effect-of-sedentary-behavior-on-obesity-and-cardiometabolic-markers-in-adults
#12
Carlos Salas, Carlos Cristi-Montero, Yu Fan, Eliana Durán, Ana María Labraña, María Adela Martínez, Ana María Leiva, Cristian Alvarez, Nicolás Aguilar-Farías, Rodrigo Ramírez-Campillo, Ximena Díaz Martínez, Ruth Sanzana-Inzunza, Carlos Celis-Morales
BACKGROUND: Sedentary behavior is a major risk factor for cardiovascular disease and mortality. AIM: To investigate whether the associations between sedentary behavior and cardiometabolic markers differs across physical activity levels. MATERIALS AND METHODS: Cross sectional study of 314 participants aged 18 to 65 years. Body mass index (BMI) and waist circumference were measured, and body fat was derived from the sum of four skinfolds. Physical activity was measured objectively using accelerometers (Actigraph GT1M, USA®)...
November 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28391241/a-variational-bayes-genomic-enabled-prediction-model-with-genotype-%C3%A3-environment-interaction
#13
Osval A Montesinos-López, Abelardo Montesinos-López, José Crossa, José Cricelio Montesinos-López, Francisco Javier Luna-Vázquez, Josaphat Salinas, José Herrera-Morales, Raymundo Buenrostro-Mariscal
There are Bayesian and non-Bayesian genomic models that take into account G×E interaction. However, the computational cost of implementing the Bayesian models is high and becomes almost impossible when the number of genotypes, environments and traits is very large, while in the non-Bayesian models, many times there are important and often unsolved convergence problems. The variational Bayes method is popular in machine learning and, by approximating the probability distributions through optimization, it tends to be faster than the Markov Chain Monte Carlo methods...
April 8, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28384425/ionoregulatory-characteristics-of-non-rio-negro-characiforms-and-cichlids
#14
R J Gonzalez, S L Jones, T V Nguyen
We examined ionoregulatory characteristics of two species of characiform fish and two species of cichlids that are not native to the Rio Negro, an extremely ion-poor, acidic tributary of the Amazon River, in order to gain insight into the origin of the specializations possessed by Rio Negro fish. The two characiform species examined, Congo tetras (Phenacogrammus interruptus) and black neon tetras (Hyphessobrycon herbertaxelrodi), had high-affinity/high-capacity transporters that produce high rates of uptake in dilute water...
May 2017: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/28383650/schizotypy-independent-and-schizotypy-modulated-cognitive-impairments-in-unaffected-first-degree-relatives-of-schizophrenia-spectrum-patients
#15
Chrysoula Zouraraki, Penny Karamaouna, Leda Karagiannopoulou, Stella G Giakoumaki
Objective: The aim of the study was to compare the neurocognitive profile of unaffected first-degree relatives of schizophrenia patients with control individuals, controlling for different schizotypal traits. Method: One hundred and fifteen adult unaffected first-degree relatives of schizophrenia-spectrum patients and 122 controls were tested for schizotypy with the Schizotypal Personality Questionnaire. They also underwent a thorough neurocognitive assessment with a range of tasks covering several aspects of executive functioning...
April 5, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28381493/recreational-concentrations-of-alcohol-enhance-synaptic-inhibition-of-cerebellar-unipolar-brush-cells-via-pre-and-postsynaptic-mechanisms
#16
Ben David Richardson, David James Rossi
Variation in cerebellar sensitivity to alcohol/ethanol (EtOH) is a heritable trait associated with alcohol use disorder (AUD) in humans and high EtOH consumption in rodents, but the underlying mechanisms are poorly understood. A recently identified cellular substrate of cerebellar sensitivity to EtOH: the GABAergic system of cerebellar granule cells (GCs), shows divergent responses to EtOH paralleling EtOH consumption and motor impairment phenotype. Although GCs are the dominant afferent integrator in the cerebellum, such integration is shared by unipolar brush cells (UBCs) in vestibulocerebellar lobes...
April 5, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28378100/physiological-responses-of-three-soybean-species-glycine-soja-g-gracilis-and-g-max-cv-melrose-to-salinity-stress
#17
Haoran Liu, Jinhui Song, Lijun Dong, Di Wang, Shuling Zhang, Jianfeng Liu
Understanding the mechanism for salt tolerance in wild soybean (Glycine soja) can help researchers improve that trait in cultivated soybean lines. We analyzed the effects of excess NaCl on the growth, physiology, and ion distribution in three soybean species: wild G. soja (W8), semi-wild G. gracilis (SW18), and the cultivated salt-sensitive G. max (cv. Melrose). These comparisons revealed that, under salt stress, shoot and root lengths and biomass (either shoot or root dry weights) were significantly higher for the W8 genotype than for the other two...
April 4, 2017: Journal of Plant Research
https://www.readbyqxmd.com/read/28376291/precipitation-affects-plant-communication-and-defense
#18
Enrico Pezzola, Stefano Mancuso, Richard Karban
Anti-herbivore defense shows high levels of both inter- and intraspecific variability. Defending against herbivores may be costly to the plant when it requires a trade-off in allocation between defense and other missed opportunities, such as reproduction. Indeed, the plastic expression of defensive traits allows the plant to invest resources in defense only when the risk of being damaged actually increases, avoiding wasted resources. Plants may assess risk by responding to volatile cues emitted by neighbors that are under attack...
April 4, 2017: Ecology
https://www.readbyqxmd.com/read/28376221/efficacy-of-nedd8-pathway-inhibition-in-preclinical-models-of-poorly-differentiated-clinically-aggressive-colorectal-cancer
#19
Gabriele Picco, Consalvo Petti, Francesco Sassi, Katia Grillone, Giorgia Migliardi, Teresa Rossi, Claudio Isella, Federica Di Nicolantonio, Ivana Sarotto, Anna Sapino, Alberto Bardelli, Livio Trusolino, Andrea Bertotti, Enzo Medico
Background: The NEDD8 conjugation pathway modulates the ubiquitination and activity of a wide range of intracellular proteins, and its blockade by pevonedistat is emerging as a promising therapeutic approach in various cancer settings. However, systematic characterization of pevonedistat efficacy in specific tumor types and definition of response predictors are still missing. Methods: We investigated in vitro sensitivity to pevonedistat in 122 colorectal cancer (CRC) cell lines by an ATP-based proliferation assay and evaluated apoptosis and DNA content by flow cytometry...
February 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28370685/non-invasive-ethylene-quantification-in-attached-fruit-headspace-at-1-ppb-by-gas-chromatography-mass-spectrometry
#20
Lara Pereira, Marta Pujol, Jordi Garcia-Mas, Michael A Phillips
Ethylene is a gaseous plant hormone involved in defense, adaptations to environmental stress, and fruit ripening. Its relevance to the latter makes its detection highly useful to physiologists interested in ripening onset. Produced as a sharp peak during the respiratory burst, ethylene is biologically active at tens of nL·L(-1) . Reliable quantification at such concentrations generally requires specialized instrumentation. Here we present a rapid, high sensitivity method for detecting ethylene in attached fruit using a conventional gas chromatography - mass spectrometry (GC-MS) system and in situ headspace collection chambers...
March 28, 2017: Plant Journal: for Cell and Molecular Biology
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