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Latent growth mixture modeling

Miriam L Haaksma, Amaia Calderón-Larrañaga, Marcel G M Olde Rikkert, René J F Melis, Jeannie-Marie S Leoutsakos
OBJECTIVE: We sought to replicate a previously published prediction model for progression, developed in the Cache County Dementia Progression Study, using a clinical cohort from the National Alzheimer's Coordinating Center. METHODS: We included 1120 incident Alzheimer disease (AD) cases with at least one assessment after diagnosis, originating from 31 AD centres from the United States. Trajectories of the Mini-Mental State Examination (MMSE) and Clinical Dementia Rating sum of boxes (CDR-sb) were modelled jointly over time using parallel-process growth mixture models in order to identify latent classes of trajectories...
May 15, 2018: International Journal of Geriatric Psychiatry
Junhan Cho, Nicholas I Goldenson, Mollie S Pester, Rubin Khoddam, Mariel S Bello, Genevieve F Dunton, Britni R Belcher, Adam M Leventhal
PURPOSE: Although evidence suggests that anhedonia-a reduced ability to experience pleasure in response to rewarding stimuli-may predict weight gain during adolescence, it remains unclear whether changes in anhedonia during adolescence are associated with changes in body mass index (BMI). This study examines longitudinal associations between changes in anhedonia and developmental trajectories of BMI during adolescence. METHODS: Self-report measures of anhedonia and BMI were collected at five semiannual assessments among students from 10 high schools in Los Angeles, CA, area (N = 3,396) followed up from the 9th grade to the 11th grade...
May 3, 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
Mitchell R Knisely, Yvette P Conley, Kord M Kober, Betty Smoot, Steven M Paul, Jon D Levine, Christine Miaskowski
Genetic variations in the catecholaminergic and serotonergic pathways may contribute to the development and severity of persistent breast pain. However, investigations of these associations are limited. The purpose of this study was to evaluate for associations between breast pain phenotypes and single nucleotide polymorphisms (SNPs) among 15 genes involved in catecholaminergic and serotonergic neurotransmission. Women rated the presence and intensity of breast pain monthly for six months following breast cancer surgery...
April 30, 2018: Journal of Pain: Official Journal of the American Pain Society
Annette M Klein, Andrea Schlesier-Michel, Yvonne Otto, Lars O White, Anna Andreas, Susan Sierau, Sarah Bergmann, Sonja Perren, Kai von Klitzing
Recent proposals suggest early adversity sets in motion particularly chronic and neurobiologically distinct trajectories of internalizing symptoms. However, few prospective studies in high-risk samples delineate distinct trajectories of internalizing symptoms from preschool age onward. We examined trajectories in a high-risk cohort, oversampled for internalizing symptoms, several preschool risk/maintenance factors, and school-age outcomes. Parents of 325 children completed the Strengths and Difficulties Questionnaire on up to four waves of data collection from preschool (3-5 years) to school age (8-9 years) and Preschool Age Psychiatric Assessment interviews at both ages...
April 29, 2018: Development and Psychopathology
Amar D Mandavia, George A Bonanno
OBJECTIVE: To determine whether there were incremental mental health impacts, specifically on depression trajectories, as a result of the 2008 economic crisis (the Great Recession) and subsequent Hurricane Sandy. METHOD: Using latent growth mixture modeling and the ORANJ BOWL dataset, we examined prospective trajectories of depression among older adults (mean age, 60.67; SD, 6.86) who were exposed to the 2 events. We also collected community economic and criminal justice data to examine their impact upon depression trajectories...
April 29, 2018: Disaster Medicine and Public Health Preparedness
Kisha I Coa, Kara P Wiseman, Bryan Higgins, Erik Augustson
Introduction: Smoking continues to be a leading cause of preventable death. Mobile health (mHealth) can extend the reach of smoking cessation programs; however, user dropout, especially in real-world implementations of these programs, limit their potential effectiveness. Research is needed to understand patterns of engagement in mHealth cessation programs. Methods: SmokefreeTXT (SFTXT) is the National Cancer Institute's 6-8 week smoking cessation text messaging intervention...
April 16, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Brian S Fuehrlein, Lorig K Kachadourian, Elizabeth K DeVylder, Louis A Trevisan, Marc N Potenza, John H Krystal, Steven M Southwick, Robert H Pietrzak
BACKGROUND AND OBJECTIVES: While alcohol use disorder is prevalent in U.S. veterans, little is known about the nature and determinants of predominant trajectories of alcohol consumption in this population. The objective of the current study was to identify predominant trajectories of alcohol consumption over a 4-year period, and baseline determinants of these trajectories in veterans. METHODS: Data were analyzed from the National Health and Resilience in Veteran Study, which surveyed a nationally representative sample of 3,157 veterans (Wave 1)...
April 18, 2018: American Journal on Addictions
L Y Saltzman, R Pat-Horenczyk, M Lombe, A Weltman, Y Ziv, T McNamara, D Takeuchi, D Brom
BACKGROUND AND OBJECTIVES: Posttraumatic stress disorder, a commonly researched mental health outcome associated with trauma, does not develop in the majority of survivors. More common trajectories of adaptation include resilience, and posttraumatic growth (PTG). The objectives of the current study were to: (1) describe posttrauma adaptation profiles in a sample of Israeli male military veterans (N = 448); and (2) to explore the protective factors that promote constructive PTG within two profiles of posttrauma adaptation...
April 12, 2018: Anxiety, Stress, and Coping
Maartje Basten, Janneke Cornelia Maria Heijne, Ronald Geskus, Chantal Den Daas, Mirjam Kretzschmar, Amy Matser
OBJECTIVE: Sexual risk behaviour changes during a person's life course. Insights in sexual risk behaviour trajectories of MSM may provide starting points for the timing of HIV prevention methods. We aimed to study longitudinal trajectories of sexual risk behaviour predictive of HIV acquisition from sexual debut onwards. DESIGN: A longitudinal study among 815 HIV-negative participants of the Amsterdam Cohort Studies (ACS) who completed extensive questionnaires about their sexual behaviour every 6 months between 2007 and 2017...
March 28, 2018: AIDS
Nagila Koster, Odilia Laceulle, Paul van der Heijden, Barbara de Clercq, Marcel van Aken
In this study, it was analysed whether trajectories of change in symptom distress could be identified in a clinical group of late adolescents with personality pathology. Furthermore, it was examined whether maladaptive personality traits and relations with parents were predictive of following one of these trajectories. Three latent classes emerged from growth mixture modelling with a symptom inventory (n = 911): a Stable High, a Strong Decreasing and a Moderate Decreasing trajectory. Subsequently, by using multinomial logistic regression analyses in a subsample of late-adolescents (n = 127), it was revealed that high levels of Negative Affectivity and Detachment were predictive of following the Strong Decreasing, and high levels of Detachment were predictive of following the Stable High trajectory...
March 25, 2018: Personality and Mental Health
Reuben O Ogollah, Kika Konstantinou, Siobhán Stynes, Kate M Dunn
OBJECTIVE: The clinical presentation and outcome of patients with back and leg pain in primary care are heterogeneous and may be better understood by identification of homogeneous and clinically meaningful subgroups. Subgroups of patients with different back pain trajectories have been identified, but little is known about the trajectories for patients with back-related leg pain. This study sought to identify distinct leg pain trajectories, and baseline characteristics associated with membership of each group, in primary care patients...
March 25, 2018: Arthritis Care & Research
Akihito Kamata, Yusuf Kara, Chalie Patarapichayatham, Patrick Lan
This study investigated the performance of three selected approaches to estimating a two-phase mixture model, where the first phase was a two-class latent class analysis model and the second phase was a linear growth model with four time points. The three evaluated methods were (a) one-step approach, (b) three-step approach, and (c) case-weight approach. As a result, some important results were demonstrated. First, the case-weight and three-step approaches demonstrated higher convergence rate than the one-step approach...
2018: Frontiers in Psychology
Yu-Chung Lawrence Wang, Hsun-Yu Chan, Pei-Chun Chen
We investigated the heterogeneous developmental trajectories of depressive symptoms in junior and senior high school, the transitions to different trajectories after entering senior high school, and the linkages to the development of depressive symptoms in early adulthood among Taiwanese adolescents. An eight-wave longitudinal data set was analyzed, including 2687 Taiwanese adolescents (51.2% boys, M age = 14.3 at first wave). Using a manual three-step latent transition growth mixture model, we found that a three-class solution fit the data for both junior high school (termed high-improving, cumulative, and JS-low-stable) and senior high school period (termed heightening, moderate-stable, and HS-low-stable)...
February 21, 2018: Journal of Abnormal Child Psychology
Camille Lassale, G David Batty, Andrew Steptoe, Dorina Cadar, Tasnime N Akbaraly, Mika Kivimäki, Paola Zaninotto
Background: Elevated systematic inflammation is a hallmark of aging, but the association of long-term inflammation trajectories with subsequent aging phenotypes has been little examined. We assessed inflammatory marker C-reactive protein (CRP) repeatedly over time and examined whether long-term changes predicted aging outcomes. Methods: A total of 2,437 men and women aged 47-87 years at baseline (1998-2001) who were participants in the English Longitudinal Study of Ageing had CRP measured on two or three occasions between 1998 and 2009...
February 15, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Jonathan P Auld, James O Mudd, Jill M Gelow, Karen S Lyons, Shirin O Hiatt, Christopher S Lee
BACKGROUND: Both heart failure symptoms and self-care are associated with patient outcomes. Although it is thought that symptoms drive self-care, there is limited evidence to support this assumption over time. AIMS: To determine whether patterns of physical symptoms are significantly associated with heart failure self-care over time. METHOD: Latent mixture analysis was used to identify subgroups based on physical symptoms of dyspnea, sleepiness and edema (using the heart failure somatic perception and Epworth sleepiness scales)...
February 1, 2018: European Journal of Cardiovascular Nursing
Derek Kenji Iwamoto, William Corbin, Jennifer Brady, Margaux Grivel, Lauren Clinton, Aylin Kaya, Carl Lejuez
BACKGROUND: Heavy episodic drinking (HED; 4 or more drinks in a 2-hour period) in U.S. college women has increased by 40% in the past 30 years. This dramatic shift suggests that women are "closing the gender gap" and are drinking at rates similar to men. Multidimensional feminine norms, or beliefs and expectations about what it means to be a woman, are theoretically promising and gender-relevant factors that may help account for within-group differences in problematic drinking patterns among this increasingly at-risk group...
March 2018: Alcoholism, Clinical and Experimental Research
Cindy-Lee Dennis, Sarah Brennenstuhl, Susitha Wanigaratne, Hilary K Brown, Sophie Grigoriadis, Flavia C Marini, Simone N Vigod
BACKGROUND: Our objectives were to identify subtypes of Chinese-Canadian women with unique trajectories of anxiety symptomatology over the first postpartum year, investigate covariates associated with group membership, and determine if mental healthcare utilization varies by group membership. METHODS: This was a longitudinal cohort study of 570 Chinese immigrant and Canadian-born women in Toronto, Canada with live births in 2010-2014. Covariates were age, immigrant status, income, fatigue, social support, acculturative stress, and depression...
April 1, 2018: Journal of Affective Disorders
Jong Won Min
OBJECTIVE: The purpose of this study is twofold: first, to identify cognitive trajectories of older Koreans in a population-based longitudinal panel survey and, second, to investigate the main characteristics of the identified heterogeneous classes of cognitive trajectories. METHODS: Data came from 2445 cognitively healthy persons aged 60 or older in the 2006 to 2012 Korean Longitudinal Study of Aging. Using Korean-mini mental status examination (K-MMSE) as a measure of global cognitive function, the latent growth mixture modeling approach examined potential heterogeneity of longitudinal changes over the 6 years...
May 2018: International Journal of Geriatric Psychiatry
Javier de la Fuente, Francisco Félix Caballero, Albert Sánchez-Niubó, Demosthenes B Panagiotakos, Matthew A Prina, Holger Arndt, Josep Maria Haro, Somnath Chatterji, José Luis Ayuso-Mateos
Background: Aging is a multidimensional process with a remarkable inter-individual variability. This study is focused on identifying groups of population with similar aging patterns, and to define the health trajectories of these groups. Socio-demographic and health determinants of these trajectories are also identified. Methods: Data from the English Longitudinal Study of Aging (ELSA) and the Health and Retirement Study (HRS) were used. A set of self-reported health items and measured tests were used to generate a latent health metric by means of a Bayesian multilevel IRT model, assessing the ability of the metric to predict mortality...
January 16, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Rens van de Schoot, Marit Sijbrandij, Sarah Depaoli, Sonja D Winter, Miranda Olff, Nancy E van Loey
There is a recent increase in interest of Bayesian analysis. However, little effort has been made thus far to directly incorporate background knowledge via the prior distribution into the analyses. This process might be especially useful in the context of latent growth mixture modeling when one or more of the latent groups are expected to be relatively small due to what we refer to as limited data. We argue that the use of Bayesian statistics has great advantages in limited data situations, but only if background knowledge can be incorporated into the analysis via prior distributions...
March 2018: Multivariate Behavioral Research
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