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Latent growth mixture modeling

Diana J Whalen, Andy C Belden, Rebecca Tillman, Deanna M Barch, Joan L Luby
OBJECTIVE: The purpose of the present report was to describe the longitudinal trajectories of physical health beginning during preschool and continuing into early adolescence; explore whether these trajectories were predicted by psychosocial adversity, family income-to-needs ratio, and psychiatric disorders occurring during the preschool period; and determine whether psychiatric disorders mediated these relations. METHODS: Participants included 296 children participating in a longitudinal study of early-onset psychopathology spanning 10 years...
October 4, 2016: Psychosomatic Medicine
Jasmine Eshragh, Anand Dhruva, Steven M Paul, Bruce A Cooper, Judy Mastick, Deborah Hamolsky, Jon D Levine, Christine Miaskowski, Kord M Kober
CONTEXT: Fatigue is a common problem in oncology patients. Less is known about decrements in energy levels and the mechanisms that underlie both fatigue and energy. OBJECTIVES: In patients with breast cancer, variations in neurotransmitter genes between Lower and Higher Fatigue latent classes and between the Higher and Lower Energy latent classes were evaluated. METHODS: Patients completed assessments prior to and monthly for 6 months following surgery...
October 5, 2016: Journal of Pain and Symptom Management
Meredith McGinley, Jennifer M Wolff, Kathleen M Rospenda, Li Liu, Judith A Richman
A two-part latent growth mixture model was implemented in order to examine heterogeneity in the growth of sexual harassment (SH) victimization in college and university students, and the extent to which SH class membership explains substance use and mental health outcomes for certain groups of students. Demographic risk factors, mental health, and substance use were examined as they related to chronically experienced SH victimization. Incoming freshmen students (N = 2855; 58% female; 54% White) completed a survey at five time points...
November 2016: Social Science Research
A Feleus, H S Miedema, S M A Bierma-Zeinstra, T Hoekstra, B W Koes, A Burdorf
OBJECTIVES: Impediments due to complaints of non-traumatic arm, neck and/or shoulder (CANS) during work often leads to consultation in primary care. This study examines the occurrence of sick leave among workers with new CANS, and evaluates sick leave trajectories and their characteristics. METHODS: This prospective 2-year cohort study included workers with a new CANS presenting in general practice. Participants filled out postal questionnaires on sick leave at 6-monthly intervals...
September 27, 2016: Occupational and Environmental Medicine
Thierno M O Diallo, Alexandre J S Morin, HuiZhong Lu
This article evaluates the impact of partial or total covariate inclusion or exclusion on the class enumeration performance of growth mixture models (GMMs). Study 1 examines the effect of including an inactive covariate when the population model is specified without covariates. Study 2 examines the case in which the population model is specified with 2 covariates influencing only the class membership. Study 3 examines a population model including 2 covariates influencing the class membership and the growth factors...
September 19, 2016: Psychological Methods
Diana Paksarian, Lihong Cui, Jules Angst, Vladeta Ajdacic-Gross, Wulf Rössler, Kathleen R Merikangas
Importance: Epidemiologic evidence indicates that most of the general population will experience a mental health disorder at some point in their lives. However, few prospective population-based studies have estimated trajectories of risk for mental disorders from young through middle adulthood to estimate the proportion of individuals who experience persistent mental disorder across this age period. Objectives: To describe the proportion of the population who experience persistent mental disorder across adulthood and to estimate latent trajectories of disorder risk across this age period...
October 1, 2016: JAMA Psychiatry
Yuping Wang, Xiongzhao Zhu, Lingyan Li, Jinyao Yi, Jincai He
OBJECTIVES: This study sought to identify the trajectories of insomnia symptoms in Chinese women with nonmetastatic breast cancer and further determine the effects of sociodemographic, disease, and psychological variables on different insomnia symptoms. METHODS: A total of 287 female breast cancer patients were recruited to complete measures of cognitive emotion regulation strategies, perceived social support, and insomnia symptoms at six time points from the week after diagnosis to four months after surgery...
August 8, 2016: Journal of Pain and Symptom Management
Getachew A Dagne
This paper presents a new Bayesian methodology for identifying a transition period for the development of drug resistance to antiretroviral drug or therapy in HIV/AIDS studies or other related fields. Estimation of such a transition period requires an availability of longitudinal data where growth trajectories of a response variable tend to exhibit a gradual change from a declining trend to an increasing trend rather than an abrupt change. We assess this clinically important feature of the longitudinal HIV/AIDS data using the bent-cable framework within a growth mixture Tobit model...
August 8, 2016: Statistics in Medicine
Neda Laiteerapong, Andrew J Karter, Howard H Moffet, Jennifer M Cooper, Robert D Gibbons, Jennifer Y Liu, Yue Gao, Elbert S Huang
AIMS: To classify trajectories of long term HbA1c values in patients after diagnosis of type 2 diabetes and examine each trajectory's associations with subsequent microvascular and macrovascular events and mortality. METHODS: A longitudinal follow-up of 28,016 patients newly diagnosed with type 2 diabetes was conducted. Latent growth mixture modeling was used to identify ten-year HbA1c trajectories. Cox proportional hazards models were used to assess how HbA1c trajectories were associated with events (microvascular and macrovascular) and mortality...
July 26, 2016: Journal of Diabetes and its Complications
Richard J Munthali, Juliana Kagura, Zané Lombard, Shane A Norris
BACKGROUND: Elevated blood pressure in childhood is a risk factor for adult hypertension which is a global health problem. Excess adiposity in childhood creates a predisposition to develop adult hypertension. Our aim was to explore distinct sex-specific adiposity trajectories from childhood to late adolescence and examined their association with blood pressure. METHODS: Latent Class Growth Mixture Modeling (LCGMM) on longitudinal data was used to derive sex-specific and distinct body mass index (BMI: kg/m(2)) trajectories...
2016: BMC Public Health
Mieko Kanayama, Machiko Suzuki, Yoshikazu Yuma
The present study aimed to identify and characterize potential burnout types and the relationship between burnout and collaboration over time. Latent class growth analysis and the growth mixture model were used to identify and characterize heterogeneous patterns of longitudinal stability and change in burnout, and the relationship between burnout and collaboration. We collected longitudinal data at three time points based on Japanese academic terms. The 396 study participants included academic teachers, yogo teachers, and registered nurses in Japanese special needs schools...
2016: Psychology Research and Behavior Management
Trine Madsen, Bregje van Spijker, Karen-Inge Karstoft, Merete Nordentoft, Ad Jfm Kerkhof
BACKGROUND: Suicidal ideation (SI) is a common mental health problem. Variability in intensity of SI over time has been linked to suicidal behavior, yet little is known about the temporal course of SI. OBJECTIVE: The primary aim was to identify prototypical trajectories of SI in the general population and, secondarily, to examine whether receiving Web-based self-help for SI, psychiatric symptoms, or sociodemographics predicted membership in the identified SI trajectories...
2016: Journal of Medical Internet Research
Martí Santacana, Bárbara Arias, Marina Mitjans, Albert Bonillo, María Montoro, Sílvia Rosado, Roser Guillamat, Vicenç Vallès, Víctor Pérez, Carlos G Forero, Miquel A Fullana
BACKGROUND: Anxiety disorders are highly prevalent and result in low quality of life and a high social and economic cost. The efficacy of cognitive-behavioural therapy (CBT) for anxiety disorders is well established, but a substantial proportion of patients do not respond to this treatment. Understanding which genetic and environmental factors are responsible for this differential response to treatment is a key step towards "personalized medicine". Based on previous research, our objective was to test whether the BDNF Val66Met polymorphism and/or childhood maltreatment are associated with response trajectories during exposure-based CBT for panic disorder (PD)...
2016: PloS One
Veronica T Cole, Daniel J Bauer
Mixture models capture heterogeneity in data by decomposing the population into latent subgroups, each of which is governed by its own subgroup-specific set of parameters. Despite the flexibility and widespread use of these models, most applications have focused solely on making inferences for whole or sub-populations, rather than individual cases. The current article presents a general framework for computing marginal and conditional predicted values for individuals using mixture model results. These predicted values can be used to characterize covariate effects, examine the fit of the model for specific individuals, or forecast future observations from previous ones...
2016: Structural Equation Modeling: a Multidisciplinary Journal
Matthew D Scalco, Craig R Colder
Informed by developmental ecological and epigenetic theory, the current study examined three aims concerning adolescent marijuana use with a large community sample (N = 755; gender = 53% female) and six annual assessments that spanned 11-18 years of age. First, the natural history of adolescent marijuana use was modeled using a two-part latent growth curve analysis. Second, the validity of the mixtures was examined with a broad array of known correlates of adolescent marijuana use. Third, temperament (e.g., surgency, effortful control, and negative affect) was tested as individual differences that would enter into statistical interactions with peer substance use and prior alcohol and cigarette use to distinguish trajectories of marijuana use...
June 20, 2016: Development and Psychopathology
Dana E Christofferson, Jeffrey S Hertzberg, Jean C Beckham, Paul A Dennis, Kim Hamlett-Berry
BACKGROUND: SmokefreeVET is a text messaging smoking cessation program available to veterans enrolled in the Veterans Health Administration. SmokefreeVET was developed in collaboration with the National Cancer Institute as part of the SmokefreeTXT initiative. PURPOSE: To evaluate the real world use of and effectiveness of the SmokefreeVET program for SmokefreeVET users who enrolled between 2013 and 2014. METHODS: Demographics and smoking behavior of 1470 SmokefreeVET users who enrolled between 2013 and 2014 were analyzed...
November 2016: Addictive Behaviors
Carol E Adair, David L Streiner, Ryan Barnhart, Brianna Kopp, Scott Veldhuizen, Michelle Patterson, Tim Aubry, Jennifer Lavoie, Jitender Sareen, Stefanie Renée LeBlanc, Paula Goering
PURPOSE: Housing First (HF) has been shown to improve housing stability, on average, for formerly homeless adults with mental illness. However, little is known about patterns of change and characteristics that predict different outcome trajectories over time. This article reports on latent trajectories of housing stability among 2140 participants (84% followed 24 months) of a multisite randomised controlled trial of HF. METHODS: Data were analyzed using generalised growth mixture modeling for the total cohort...
April 15, 2016: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
Hannes Kröger, Johan Fritzell, Rasmus Hoffmann
BACKGROUND: The study of the influence of life course occupational position (OP) on health in old age demands analysis of time patterns in both OP and health. We study associations between life course time patterns of OP and decline in grip strength in old age. METHODS: We analyze 5 waves from the Survey of Health Ageing and Retirement in Europe (n = 5108, ages 65-90). We use a pattern-mixture latent growth model to predict the level and decline in grip strength in old age by trajectory of life course OP...
2016: PloS One
David Córdova, Seth J Schwartz, Jennifer B Unger, Lourdes Baezconde-Garbanati, Juan A Villamar, Daniel W Soto, Sabrina E Des Rosiers, Tae Kyoung Lee, Alan Meca, Miguel Ángel Cano, Elma I Lorenzo-Blanco, Assaf Oshri, Christopher P Salas-Wright, Brandy Piña-Watson, Andrea J Romero
Parent-adolescent discrepancies in family functioning play an important role in HIV risk behaviors among adolescents, yet longitudinal research with recent immigrant Hispanic families remains limited. This study tested the effects of trajectories of parent-adolescent family functioning discrepancies on HIV risk behaviors among recent-immigrant Hispanic adolescents. Additionally, we examined whether and to what extent trajectories of parent-adolescent family functioning discrepancies vary as a function of gender...
October 2016: Journal of Youth and Adolescence
Fanhui Kong, Yeh-Fong Chen
By examining the outcome trajectories of the dropout patients with different reasons in the schizophrenia trials, we note that although patients are recruited from the same protocol that have compatible baseline characteristics, they may respond differently even to the same treatment. Some patients show consistent improvement while others only have temporary relief. This creates different patient subpopulations characterized by their response and dropout patterns. At the same time, those who continue to improve seem to be more likely to complete the study while those who only experience temporary relief have a higher chance to drop out...
July 2016: Pharmaceutical Statistics
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