keyword
https://read.qxmd.com/read/38157720/the-association-of-therapeutic-hypothermia-with-seizure-burden-in-neonates-with-hypoxic-ischemic-encephalopathy
#21
JOURNAL ARTICLE
Noa Arad, Irina Meledin, Itai Hazan, Iris Noyman, Kyla A Marks, Ramy Abramsky, Eilon Shany
OBJECTIVES: To compare seizure burden between newborn infants treated with therapeutic hypothermia (TH) and those that were not and to compare the need for antiseizure medications (ASM) in a cohort of infants who were diagnosed with neonatal hypoxic-ischemic encephalopathy (HIE). METHODS: This was a retrospective cohort study on infants born after 35 weeks' gestation, diagnosed with moderate to severe HIE, monitored with amplitude-integrated electroencephalography (aEEG) and eligible for TH...
February 2024: Pediatric Neurology
https://read.qxmd.com/read/38150307/short-term-outcomes-of-neonates-with-hypoxic-ischemic-encephalopathy-receiving-active-versus-passive-cooling-during-transport
#22
JOURNAL ARTICLE
Ricky Rana, Ashleigh Manktelow, Elizabeth Lyden, Eric S Peeples
Therapeutic hypothermia (TH) is the only currently approved treatment for neonatal hypoxic-ischemic encephalopathy (HIE) and must be started within 6 hours to optimize effectiveness. This narrow therapeutic window often requires initiation of TH before or during transport. The goal of this study was to assess the effects of servo-controlled TH versus passive hypothermia during transport on short-term outcomes in newborns with HIE. This was a single-center retrospective case-control study of neonates with HIE treated with active or passive TH during transport...
December 26, 2023: Therapeutic Hypothermia and Temperature Management
https://read.qxmd.com/read/38089686/no-neuroprotective-effect-of-therapeutic-hypothermia-following-lipopolysaccharide-sensitized-hypoxia-ischemia-a-newborn-piglet-study
#23
JOURNAL ARTICLE
Mads Andersen, Hannah Brogård Andersen, Ted Carl Kejlberg Andelius, Lærke Hjøllund Hansen, Regitze Pinnerup, Mette Bjerre, Steffen Ringgaard, Leslie Schwendimann, Pierre Gressens, Kasper Jacobsen Kyng, Tine Brink Henriksen
INTRODUCTION: Therapeutic hypothermia is the only proven neuroprotective treatment for hypoxic-ischemic encephalopathy. However, studies have questioned whether therapeutic hypothermia may benefit newborns subjected to infection or inflammation before a hypoxic-ischemic insult. We aimed to compare newborn piglets with lipopolysaccharide-sensitized hypoxia-ischemia treated with and without therapeutic hypothermia with regards to measures of neuroprotection. METHODS: A total of 32 male and female piglets were included in this randomized experimental study...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38073399/the-influence-of-late-prematurity-on-the-encephalopathy-exam-of-infants-with-neonatal-encephalopathy
#24
JOURNAL ARTICLE
A Kodidhi, M Riley, Z Vesoulis
BACKGROUND: Late preterm (LPT) infants are increasingly treated for hypoxic-ischemic encephalopathy (HIE). However, neurodevelopmental differences of LPT infants may independently influence the neurologic exam and confound care. METHODS: Perinatal and outcome characteristics were extracted along with the worst autonomic and state/neuromuscular/reflex Sarnat components in a cross-section of infants with moderate/severe HIE. Infants were classified as late preterm (LPT, 34-36 weeks) or term (>36 weeks)...
December 7, 2023: Journal of Neonatal-perinatal Medicine
https://read.qxmd.com/read/38071538/evolution-of-the-sarnat-exam-and-association-with-2-year-outcomes-in-infants-with-moderate-or-severe-hypoxic-ischaemic-encephalopathy-a-secondary-analysis-of-the-heal-trial
#25
JOURNAL ARTICLE
Ulrike Mietzsch, Sarah E Kolnik, Thomas Ragnar Wood, Niranjana Natarajan, Fernando F Gonzalez, Hannah Glass, Dennis E Mayock, Sonia L Bonifacio, Krisa Van Meurs, Bryan A Comstock, Patrick J Heagerty, Tai-Wei Wu, Yvonne W Wu, Sandra E Juul
OBJECTIVE: To study the association between the Sarnat exam (SE) performed before and after therapeutic hypothermia (TH) and outcomes at 2 years in infants with moderate or severe hypoxic-ischaemic encephalopathy (HIE). DESIGN: Secondary analysis of the H igh-dose E rythropoietin for A sphyxia and Encepha L opathy Trial. Adjusted ORs (aORs) for death or neurodevelopmental impairment (NDI) based on SE severity category and change in category were constructed, adjusting for sedation at time of exam...
November 27, 2023: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://read.qxmd.com/read/38061422/neonatal-hypoxic-ischemic-encephalopathy-spectrum-severity-stratified-analysis-of-neuroimaging-modalities-and-association-with-neurodevelopmental-outcomes
#26
JOURNAL ARTICLE
Mehmet N Cizmeci, Diane Wilson, Maya Singhal, Amr El Shahed, Brian Kalish, Emily Tam, Vann Chau, Linh Ly, Vanna Kazazian, Cecil Hahn, Helen Branson, Steven P Miller
OBJECTIVE: To compare hypoxic-ischemic injury on early cranial ultrasonography (cUS) and post-rewarming brain magnetic resonance imaging (MRI) in newborn infants with hypoxic-ischemic encephalopathy (HIE) and to correlate that neuroimaging with neurodevelopmental outcomes. STUDY DESIGN: This was a retrospective cohort study of infants with mild, moderate, and severe HIE treated with therapeutic hypothermia and evaluated with early cUS and postrewarming MRI. Validated scoring systems were used to compare the severity of brain injury on cUS and MRI...
March 2024: Journal of Pediatrics
https://read.qxmd.com/read/38057259/a-novel-clinical-risk-scoring-system-for-neurodevelopmental-outcomes-among-survivors-of-neonatal-hypoxic-ischemic-encephalopathy-hie
#27
JOURNAL ARTICLE
Theresa Estiphan, Julie Sturza, Renée A Shellhaas, Martha D Carlson
OBJECTIVE: We aimed to develop a risk scoring system as a predictor of 24-month neurodevelopmental outcomes (cognitive, language, and motor) for neonates treated with therapeutic hypothermia for hypoxic-ischemic encephalopathy (HIE). METHODS: This was a chart review of infants with HIE treated with therapeutic hypothermia who were admitted to the Neonatal Intensive Care Unit (NICU) at the University of Michigan between 2009 and 2019 and followed in the neonatal developmental clinic until 24 months of age...
December 2, 2023: Pediatrics and Neonatology
https://read.qxmd.com/read/38036441/potential-adjuncts-to-therapeutic-hypothermia-to-mitigate-multiorgan-injury-in-perinatal-hypoxia-ischemia
#28
REVIEW
Megan J Turner, Robert M Dietz
Over the last 2 decades, therapeutic hypothermia has become the standard of care to reduce morbidity and mortality in neonates affected by moderate-to-severe hypoxic-ischemic encephalopathy (HIE). There is a significant interest in improving the neurologic outcomes of neonatal HIE, ranging from adjunctive therapy to therapeutic hypothermia. Importantly, the pathophysiologic mechanisms underlying HIE also affect multiple other organs, contributing to high morbidity and mortality in this patient population. This review focuses on the adjunct therapies currently under investigation to mitigate the impact of hypoxic-ischemic injury on the brain, kidneys, liver, heart, and gastrointestinal system...
December 1, 2023: NeoReviews
https://read.qxmd.com/read/38006967/time-to-reaching-target-cooling-temperature-and-2-year-outcomes-in-infants-with-hypoxic-ischemic-encephalopathy
#29
JOURNAL ARTICLE
Rakesh Rao, Bryan A Comstock, Tai-Wei Wu, Ulrike Mietzsch, Dennis E Mayock, Fernando F Gonzalez, Thomas R Wood, Patrick J Heagerty, Sandra E Juul, Yvonne W Wu
OBJECTIVE: To determine if time to reaching target temperature (TT) is associated with death or neurodevelopmental impairment (NDI) at 2 years of age in infants with hypoxic-ischemic encephalopathy (HIE). STUDY DESIGN: Newborn infants ≥36 weeks of gestation diagnosed with moderate or severe HIE and treated with therapeutic hypothermia were stratified based on time at which TT was reached, defined as early (ie, ≤4 hours of age) or late (>4 hours of age)...
November 23, 2023: Journal of Pediatrics
https://read.qxmd.com/read/37966836/remote-monitoring-for-seizures-during-therapeutic-hypothermia-in-neonates-with-hypoxic-ischemic-encephalopathy
#30
MULTICENTER STUDY
Gabriel Fernando Todeschi Variane, Alex Dahlen, Rafaela Fabri Rodrigues Pietrobom, Daniela Pereira Rodrigues, Maurício Magalhães, Marcelo Jenné Mimica, Nathalie Salles Llaguno, Danieli Mayumi Kimura Leandro, Paula Natale Girotto, Leticia Brito Sampaio, Krisa Page Van Meurs
IMPORTANCE: Neonates with hypoxic-ischemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH) frequently experience seizures, which are associated with adverse outcomes. Efforts to rapidly identify seizures and reduce seizure burden may positively change neurologic and neurodevelopmental outcomes. OBJECTIVE: To describe the onset, treatment, and evolution of seizures in a large cohort of newborns with HIE during TH assisted by a telehealth model and remote neuromonitoring approach...
November 1, 2023: JAMA Network Open
https://read.qxmd.com/read/37958562/early-neuroprotective-effects-of-bovine-lactoferrin-associated-with-hypothermia-after-neonatal-brain-hypoxia-ischemia-in-rats
#31
JOURNAL ARTICLE
Eduardo Sanches, Yohan van de Looij, Dini Ho, Laura Modernell, Analina da Silva, Stéphane Sizonenko
Neonatal hypoxic-ischemic (HI) encephalopathy (HIE) in term newborns is a leading cause of mortality and chronic disability. Hypothermia (HT) is the only clinically available therapeutic intervention; however, its neuroprotective effects are limited. Lactoferrin (LF) is the major whey protein in milk presenting iron-binding, anti-inflammatory and anti-apoptotic properties and has been shown to protect very immature brains against HI damage. We hypothesized that combining early oral administration of LF with whole body hypothermia could enhance neuroprotection in a HIE rat model...
October 25, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37947046/perinatal-asphyxia-does-not-influence-presepsin-levels-in-neonates-a-prospective-study
#32
JOURNAL ARTICLE
Chiara Maddaloni, Domenico Umberto De Rose, Marco Perulli, Ludovica Martini, Iliana Bersani, Francesca Campi, Immacolata Savarese, Andrea Dotta, Maria Paola Ronchetti, Cinzia Auriti
AIM: To compare Presepsin (presepsin) levels in plasma and urine of uninfected newborn infants with perinatal asphyxia with those of controls. METHODS: In this prospective study, we enrolled 25 uninfected full-term infants with perinatal asphyxia and 19 controls. We measured presepsin levels in whole blood or urine. In neonates with perinatal asphyxia, we compared presepsin levels in blood and urine at four time points. RESULTS: In neonates with perinatal asphyxia, blood and urinary presepsin levels matched each other at any time point...
November 10, 2023: Acta Paediatrica
https://read.qxmd.com/read/37920623/evaluation-of-pain-prevalence-in-children-who-experienced-perinatal-hypoxia-ischemia-events-characteristics-and-associations-with-sociodemographic-factors
#33
JOURNAL ARTICLE
Giovanna Maria G Von Adamovich, João Antonio G Bastos Torres, Felipe S Vianna, Penha C Barradas, Beatriz F Alves de Oliveira, Nivaldo R Villela, Maura Calixto C De Rodrigues, Guilherme C Montes
INTRODUCTION: Pain in children who suffer from hypoxia-ischemia (HI) events is still not widely studied. Hypoxia-ischemia is characterized by the momentary or permanent cessation of blood flow and, consequently, of oxygen supply, becoming the main cause of encephalopathy in children. Hyperalgesia was identified in animals undergoing prenatal hypoxia-ischemia by researchers from the Universidade do Estado do Rio de Janeiro (UERJ). Premature and asphyxiated newborns have been admitted to the neonatal intensive care unit (NICU) of Pedro Ernesto University Hospital (HUPE) in Brazil and are monitored by the Outpatient Follow-up of High-Risk Newborns Project (SARAR), but no pain assessment was performed...
October 2023: Curēus
https://read.qxmd.com/read/37892791/advances-in-therapies-to-treat-neonatal-hypoxic-ischemic-encephalopathy
#34
REVIEW
Amaresh K Ranjan, Anil Gulati
Neonatal hypoxic-ischemic encephalopathy (HIE) is a condition that results in brain damage in newborns due to insufficient blood and oxygen supply during or after birth. HIE is a major cause of neurological disability and mortality in newborns, with over one million neonatal deaths occurring annually worldwide. The severity of brain injury and the outcome of HIE depend on several factors, including the cause of oxygen deprivation, brain maturity, regional blood flow, and maternal health conditions. HIE is classified into mild, moderate, and severe categories based on the extent of brain damage and resulting neurological issues...
October 20, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37892154/newborns-with-favourable-outcomes-after-perinatal-asphyxia-have-upregulated-glucose-metabolism-related-proteins-in-plasma
#35
JOURNAL ARTICLE
Ping K Yip, Michael Bremang, Ian Pike, Vennila Ponnusamy, Adina T Michael-Titus, Divyen K Shah
Hypoxic-ischaemic encephalopathy (HIE) is an important cause of morbidity and mortality globally. Although mild therapeutic hypothermia (TH) may improve outcomes in selected babies, the mechanism of action is not fully understood. A proteomics discovery study was carried out to analyse proteins in the plasma of newborns with HIE. Proteomic analysis of plasma from 22 newborns with moderate-severe HIE that had initially undergone TH, and relative controls including 10 newborns with mild HIE who did not warrant TH and also cord blood from 10 normal births (non-HIE) were carried out using the isobaric Tandem Mass Tag (TMT® ) 10plexTM labelling with tandem mass spectrometry...
September 30, 2023: Biomolecules
https://read.qxmd.com/read/37889282/renal-artery-flow-alterations-in-neonates-with-hypoxic-ischemic-encephalopathy
#36
JOURNAL ARTICLE
Banu Aydın, Nurullah Okumuş, Mehmet Burak Özkan, Ayşegül Zenciroğlu, Dilek Dilli, Serdar Beken
BACKGROUND: To compare kidney blood flow and kidney function tests in infants with hypoxic ischemic encephalopathy (HIE), and the effects of therapeutic hypothermia (TH) during the first 7 days of life. METHODS: Fifty-nine infants with HIE were prospectively evaluated. Infants with moderate-severe HIE who required TH were classified as group 1 (n = 36), infants with mild HIE were classified as group 2 (n = 23), and healthy infants were classified as group 3 (n = 60)...
October 27, 2023: Pediatric Nephrology
https://read.qxmd.com/read/37833970/differential-effects-of-hypothermia-and-szr72-on-cerebral-kynurenine-and-kynurenic-acid-in-a-piglet-model-of-hypoxic-ischemic-encephalopathy
#37
JOURNAL ARTICLE
Ferenc Domoki, Valéria Tóth-Szűki, Viktória Kovács, Gábor Remzső, Tímea Körmöczi, László Vécsei, Róbert Berkecz
Kynurenic acid (KYNA), an endogenous neuroprotectant with antiexcitotoxic, antioxidant, and anti-inflammatory effects, is synthesized through the tryptophan-kynurenine (KYN) pathway. We investigated whether brain KYN or KYNA levels were affected by asphyxia in a translational piglet model of hypoxic-ischemic encephalopathy (HIE). We also studied brain levels of the putative blood-brain barrier (BBB) permeable neuroprotective KYNA analogue SZR72, and whether SZR72 or therapeutic hypothermia (TH) modified KYN or KYNA levels...
September 25, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37822185/l-f001-a-multifunctional-fasudil-lipoic-acid-dimer-antagonizes-hypoxic-ischemic-brain-damage-by-inhibiting-the-tlr4-myd88-signaling-pathway
#38
JOURNAL ARTICLE
Ruiyu Zhou, Liqiang Wu, Ni Jin, Sha Sha, Ying Ouyang
INTRODUCTION: Neonatal hypoxic-ischemic brain damage (HIBD) is a serious inflammatory injury. At present, the standard treatment for this disease is hypothermia therapy, and the effect of drug intervention is still limited. L-F001 is a compound of fasudil and lipoic acid. Previous in vitro experiments have confirmed that L-F001 has anti-inflammatory neuroprotective functions. However, its therapeutic effect on neonates with HIBD remains unknown. This study was aimed at exploring the therapeutic effect of L-F001 on HIBD rats...
October 11, 2023: Brain and Behavior
https://read.qxmd.com/read/37806836/progress-in-the-treatment-of-neonatal-hypoxic-ischemic-encephalopathy-with-umbilical-cord-blood-mononuclear-cells
#39
REVIEW
Jiayu Zhou, Ting Gao, Wan Tang, Tianyang Qian, Ziming Wang, Pu Xu, Laishuan Wang
Neonatal hypoxic-ischemic encephalopathy (HIE) is a common disease among newborns, which is a leading cause of neonatal death and permanent neurological sequelae. Therapeutic hypothermia (TH) is the only method for the treatment of HIE that has been recognized effective clinically at home and abroad, but the efficacy is limited. Recent research suggests that the cord blood-derived mononuclear cells (CB-MNCs), which the refer to blood cells containing one nucleus in the cord blood, exert anti-oxidative, anti-inflammatory, anti-apoptotic effects and play a neuroprotective role in HIE...
November 2023: Brain & Development
https://read.qxmd.com/read/37773520/is-erythropoietin-beneficial-and-safe-as-an-adjunctive-therapy-to-therapeutic-hypothermia-in-newborns-with-hypoxic-ischemic-injury
#40
JOURNAL ARTICLE
Abigail L Melemed, Jonathan L Slaughter, Kristen L Benninger, Sara Conroy
No abstract text is available yet for this article.
September 29, 2023: Journal of Perinatology: Official Journal of the California Perinatal Association
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