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Neonatal hypertension

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https://www.readbyqxmd.com/read/29785061/targeted-neonatal-echocardiography-tne-consult-service-in-a-large-tertiary-perinatal-center-in-canada
#1
Ismina Papadhima, Deepak Louis, Jyotsna Purna, Poorva Deshpande, Yenge Diambomba, Shoo Lee, Prakesh Shah, Dany Weisz, Afif El-Khuffash, Patrick J McNamara, Luc Mertens, Amish Jain
OBJECTIVE: To describe the utilization and study the factors associated with the impact on clinical management of a new TNE consultation service in a perinatal center. METHODS: This retrospective cohort study included all neonates who underwent TNE consultation at the neonatal unit of Mount Sinai Hospital in Toronto, Canada (November 2011 and July 2015). The consults that had "impact" were defined as those that led to a TNE suggested change in the clinical management within 6 h of its recommendation...
May 22, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29779144/effect-of-pre-gravid-body-mass-index-on-outcomes-of-pregnancies-following-in-vitro-fertilization
#2
Miha Lucovnik, Isaac Blickstein, Tomislav Mirkovic, Ivan Verdenik, Katja Bricelj, Marijana Vidmar Simic, Natasa Tul, Andreja Trojner Bregar
PURPOSE: To examine the effect of pre-gravid body mass index (BMI) on perinatal outcomes in in vitro fertilization (IVF) singleton pregnancies. METHODS: Retrospective population-based cohort study. All singleton pregnancies delivered at ≥ 22 weeks' in Slovenia between 2002 and 2015 were included. Logistic regression analysis was used to examine the relationship between BMI category and outcomes, controlling for potential confounding variables. Interaction term was included to evaluate whether effects of obesity on perinatal outcomes differ in IVF vs...
May 19, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29764471/inhaled-nitric-oxide-as-a-rescue-therapy-in-a-preterm-neonate-with-severe-pulmonary-hypertension-a-case-report
#3
Martina Busè, Francesco Graziano, Fabio Lunetta, Giorgio Sulliotti, Vincenzo Duca
BACKGROUND: Inhaled nitric oxide (iNO) has been approved for the treatment of persistent pulmonary hypertension of the newborn (PPHN) in term and near-term newborns. Its role in the management of persistent pulmonary hypertension in preterm infants is not clear. Although guidelines do not exist, some studies have shown that iNO could be used as a rescue therapy in preterm neonate with severe pulmonary hypertension. CASE PRESENTATION: We describe the case of a preterm neonate, born at 30 + 1 weeks of gestation, with hypoxic respiratory failure not responding to maximal conventional therapy...
May 15, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29752563/alamandine-attenuates-hypertension-and-cardiac-hypertrophy-in-hypertensive-rats
#4
Chi Liu, Chuan-Xi Yang, Xi-Ru Chen, Bo-Xun Liu, Yong Li, Xiao-Zhi Wang, Wei Sun, Peng Li, Xiang-Qing Kong
Oral administration of the peptide alamandine has antihypertensive and anti-fibrotic effects in rats. This work aimed to determine whether subcutaneous alamandine injection would attenuate hypertension and cardiac hypertrophy, and improve the function of a major target of hypertension-related damage, the left ventricle (LV), in spontaneously hypertensive rats (SHRs). This was examined in vivo in SHRs and normotensive rats subjected to 6-week subcutaneous infusion of alamandine or saline control, and in vitro in H9C2-derived and primary neonatal rat cardiomyocytes treated with angiotensin (Ang) II to model cardiac hypertrophy...
May 12, 2018: Amino Acids
https://www.readbyqxmd.com/read/29740191/neonatal-outcomes-of-extremely-preterm-infants-exposed-to-maternal-hypertension-and-cigarette-smoking
#5
Kamran Yusuf, Belal Alshaikh, Orlando da Silva, Abhay K Lodha, Robert D Wilson, Ruben E Alvaro, Shoo K Lee, Prakesh S Shah
OBJECTIVE: To study the outcomes of extremely preterm infants of hypertensive mothers who smoke. STUDY DESIGN: This retrospective cohort study included infants born between 2003 and 2012 at <29 weeks' gestation and admitted to neonatal intensive care units participating in the Canadian Neonatal Network. Infants were divided into four mutually exclusive groups. Infants of hypertensive mothers who smoked; infants of hypertensive, non-smoking mothers; infants of normotensive mothers who smoked; and infants of normotensive, non-smoking mothers...
May 8, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29738332/anesthetic-care-of-2-siblings-with-neonatal-ichthyosis-and-sclerosing-cholangitis-syndrome-case-reports
#6
Céline Khalifa, Geoffrey Boliaki Botombe, Xavier Stephenne, Francis Veyckemans
We report for the first time the anesthetic management of 2 sisters suffering from neonatal ichthyosis and sclerosing cholangitis syndrome. They both presented with neonatal cholestatic jaundice and ichthyosis. The first was admitted for orthotopic liver transplantation at the age of 1 year, and the second patient underwent open pyeloplasty for a pyeloureteric junction syndrome at the age of 4 years. These 2 case reports highlight that, except for the potential difficulties with securing the catheters, dressings and endotracheal tube to the skin, the anesthetic implications of neonatal ichthyosis and sclerosing cholangitis syndrome are mainly related to the liver disease: cirrhosis and portal hypertension...
May 7, 2018: A&A practice
https://www.readbyqxmd.com/read/29737875/the-discovery-of-protein-biomarkers-in-pre-eclmmpsia-the-promising-role-of-mass-spectrometry
#7
Lina A Dahabiyeh
CONTEXT: Pre-eclampsia (PE) is a common hypertensive disorder of pregnancy that substantially affects maternal and neonatal morbidity and mortality worldwide. The etiology of the disease remains poorly understood with lack of reliable diagnostic tests. PE is a multisystem disorder so it is very unlikely that a single or a small group of biomarkers will accurately predict the disease. Mass spectrometry (MS) is indispensable analytical tool in protein analysis studies. MS-based proteomics have the ability to detect the entire protein complement to provide a useful window into a range of biological processes and allow the identification of differentially expressed proteins between samples...
May 8, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29734386/renal-papillary-tip-extract-stimulates-bnp-production-and-excretion-from-cardiomyocytes
#8
Itaru Goto, Ryuji Okamoto, Ryotaro Hashizume, Noboru Suzuki, Rie Ito, Keiichi Yamanaka, Hiromitsu Saito, Hiroshi Kiyonari, Isao Tawara, Yuki Kageyama, Yoshito Ogihara, Yusuf Ali, Norikazu Yamada, Naoyuki Katayama, Masaaki Ito
BACKGROUND: Brain natriuretic peptide (BNP) is an important biomarker for patients with cardiovascular diseases, including heart failure, hypertension and cardiac hypertrophy. It is also known that BNP levels are relatively higher in patients with chronic kidney disease and no heart disease; however, the mechanism remains unclear. METHODS AND RESULTS: We developed a BNP reporter mouse and occasionally found that this promoter was activated specifically in the papillary tip of the kidneys, and its activation was not accompanied by BNP mRNA expression...
2018: PloS One
https://www.readbyqxmd.com/read/29733824/preoperative-aortic-arch-size-and-late-outcome-following-coarctation-repair-via-lateral-thoracotomy
#9
Preeti Ramachandran, Philip R Khoury, Robert H Beekman, Erik C Michelfelder, Peter B Manning, James S Tweddell, James F Cnota
BACKGROUND: The approach (lateral thoracotomy vs median sternotomy) to repair coarctation of aorta is frequently based on arch dimensions from the preoperative echocardiogram. Few studies have assessed the relationship between preoperative arch dimensions and late postoperative outcome. This study aims to define how preoperative arch dimensions relate to late outcomes and identify long term predictors of successful surgery. METHODS: We performed a retrospective review of 102 neonates and infants undergoing isolated coarctation repair via lateral thoracotomy between 2003-2012...
May 4, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29725376/low-dose-aspirin-at-%C3%A2-16-weeks-of-gestation-for-preventing-preeclampsia-and-its-maternal-and-neonatal-adverse-outcomes-a-systematic-review-and-meta-analysis
#10
Yuechong Cui, Bin Zhu, Fei Zheng
The aim of the present meta-analysis study was to evaluate the efficacy of low-dose aspirin, commenced at ≤16 weeks of gestation, in preventing preterm and term preeclampsia, as well as associated maternal and neonatal adverse events in women at risk of preeclampsia. The Embase, PubMed, Cochrane Central Register of Controlled Trials and the Web of Science databases were searched for relevant random controlled trials (RCTs) published between January 1979 and October 2017. After quality assessment and data extraction, a meta-analysis was performed using RevMan 5...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29723237/association-of-maternal-nutrition-with-transient-neonatal-hyperinsulinism
#11
Mathilde Louvigne, Stephanie Rouleau, Emmanuelle Caldagues, Isabelle Souto, Yanis Montcho, Audrey Migraine Bouvagnet, Olivier Baud, Jean Claude Carel, Geraldine Gascoin, Regis Coutant
OBJECTIVE: The objective was to determine whether maternal nutritional factors are associated with transient neonatal hyperinsulinism (HI). DESIGN AND SETTING: Case control study in 4 French tertiary Obstetrics and Neonatology Departments between 2008 and 2015. METHODS: Sixty-seven mothers of neonates diagnosed with transient hyperinsulinism and 113 mothers of controls were included. The screening for hyperinsulinemic hypoglycemia in neonates was performed because of clinical symptoms suggestive of hypoglycemia or in the presence of conventional risk factors (small-for-gestational-age, prematurity, anoxo-ischemia, hypothermia, macrosomia, gestational diabetes)...
2018: PloS One
https://www.readbyqxmd.com/read/29720114/adverse-obstetric-and-neonatal-outcomes-complicated-by-psychosis-among-pregnant-women-in-the-united-states
#12
Qiu-Yue Zhong, Bizu Gelaye, Gregory L Fricchione, Paul Avillach, Elizabeth W Karlson, Michelle A Williams
BACKGROUND: Adverse obstetric and neonatal outcomes among women with psychosis, particularly affective psychosis, has rarely been studied at the population level. We aimed to assess the risk of adverse obstetric and neonatal outcomes among women with psychosis (schizophrenia, affective psychosis, and other psychoses). METHODS: From the 2007 - 2012 National (Nationwide) Inpatient Sample, 23,507,597 delivery hospitalizations were identified. From the same hospitalization, International Classification of Diseases diagnosis codes were used to identify maternal psychosis and outcomes...
May 2, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29718786/association-between-serum-ca125-levels-in-preeclampsia-and-its-severity-among-women-in-lagos-south-west-nigeria
#13
Gbemisola E Osanyin, Kehinde S Okunade, Ayodeji Ayotunde Oluwole
BACKGROUND: Preeclampsia is a syndrome of unknown etiology characterized by hypertension, proteinuria, and/or organ dysfunction. CA125 is an antigenic determinant recognized by the murine monoclonal antibody OC125 quantified by radioimmunoassay. Its role in obstetrics is yet to be fully understood as most clinical trials advocating its uses are widely experimental in nature and unacknowledged. AIM: This study was done to assess the relationship between serum concentration of CA125 in normal pregnancies and those complicated with preeclampsia...
May 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29714433/peritoneal-dialysis-in-neonates-six-years-of-single-center-experience
#14
Ferda Özlü, Hacer Yapıcıoğlu Yıldızdaş, Gül Şeker, Hüseyin Şimşek, Aysun Karabay Bayazıt, Mehmet Satar
Background/aim: Peritoneal dialysis (PD) is generally considered the practical dialysis modality for neonates in the treatment of acute kidney injury (AKI) and metabolic disturbances. The aim of this study was to evaluate the indications, complications, and outcomes of PD between January 2011 and December 2016. Materials and methods: This study included all 56 neonates that underwent PD over six years in our neonatal intensive care unit (NICU). A retrospective chart review was performed for all patients in our institution...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29713814/prenatal-intervention-for-the-management-of-congenital-diaphragmatic-hernia
#15
REVIEW
Mariatu A Verla, Candace C Style, Oluyinka O Olutoye
Congenital diaphragmatic hernia (CDH) is the result of incomplete formation of the diaphragm that occurs during embryogenesis. The defect in the diaphragm permits the herniation of abdominal organs into the thoracic cavity contributing to the impairment of normal growth and development of the fetal lung. In addition to the hypoplastic lung, anomalies of the pulmonary arterioles worsen the pulmonary hypertension that can have detrimental effects in severe cases. Most cases of CDH can be effectively managed postnatally...
April 30, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29712482/does-pregnancy-interval-after-laparoscopic-sleeve-gastrectomy-affect-maternal-and-perinatal-outcomes
#16
Alper Basbug, Aşkı Ellibeş Kaya, Sami Dogan, Mevlut Pehlivan, Gokhan Goynumer
BACKGROUND: Obesity is a global health epidemic and is associated with many maternal and neonatal complications. Laparoscopic sleeve gastrectomy (LSG) is among the surgical treatments for obesity. The appropriate timing of pregnancy following LSG remains controversial and few studies have evaluated this public health issue. OBJECTIVE: To evaluate the effect of pregnancy timing after LSG on maternal and perinatal outcomes. STUDY DESIGN: We performed a retrospective observational study of 23 pregnant women who underwent LSG at a tertiary hospital in Turkey...
April 30, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29695022/catheter-related-arterial-thrombosis-in-neonates-and-children-a-systematic-review
#17
Mattia Rizzi, Neil Goldenberg, Mariana Bonduel, Shoshana Revel-Vilk, Ernest Amankwah, Manuela Albisetti
Catheter-related arterial thrombosis (CAT) is increasingly recognized in children. Available data are scarce and based on expert opinions. This systematic review aimed to identify knowledge on paediatric CAT. Among 3,484 publications, 22 met inclusion criteria. Fourteen reported on CAT due to umbilical arterial catheter (UAC), two to extremity indwelling catheter (EIC), one to both and five to cardiac catheter (CC). The overall cumulative incidence of CAT was 21% (95% confidence interval [CI], 13-31) with a relative incidence of 20% (95% CI, 10-33) for UAC and 11% (95% CI, 3-21) for CC-related CAT...
April 25, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29693726/uterotonic-agents-for-preventing-postpartum-haemorrhage-a-network-meta-analysis
#18
REVIEW
Ioannis D Gallos, Helen M Williams, Malcolm J Price, Abi Merriel, Harold Gee, David Lissauer, Vidhya Moorthy, Aurelio Tobias, Jonathan J Deeks, Mariana Widmer, Özge Tunçalp, Ahmet Metin Gülmezoglu, G Justus Hofmeyr, Arri Coomarasamy
BACKGROUND: Postpartum haemorrhage (PPH) is the leading cause of maternal mortality worldwide. Prophylactic uterotonic drugs can prevent PPH, and are routinely recommended. There are several uterotonic drugs for preventing PPH but it is still debatable which drug is best. OBJECTIVES: To identify the most effective uterotonic drug(s) to prevent PPH, and generate a ranking according to their effectiveness and side-effect profile. SEARCH METHODS: We searched Cochrane Pregnancy and Childbirth's Trials Register (1 June 2015), ClinicalTrials...
April 25, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29692677/comparative-study-of-obstetric-and-neonatal-outcomes-of-live-births-between-poor-and-good-quality-embryo-transfers
#19
Kozue Akamine, Keiko Mekaru, Keiya Gibo, Chinatsu Nagata, Sugiko Oishi, Maho Miyagi, Chiaki Heshiki, Tadatugu Kinjo, Hitoshi Masamoto, Yoichi Aoki
Purpose: To evaluate the effect of embryo quality on pregnancy outcomes. Methods: This retrospective analysis included 80 live singleton births, resulting from morphologically good-quality embryo transfers, and 25 live singleton births that resulted from morphologically poor-quality embryo transfers between January, 2008 and December, 2014. Cleavage embryos that were graded as ≥2, according to the Veeck classification system, and blastocysts that were graded as ≥3BB, according to the Gardner classification system, were defined as good quality...
April 2018: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29689321/gestational-weight-gain-and-weight-loss-among-women-with-gestational-diabetes-mellitus
#20
Daphna Komem, Lina Salman, Eyal Krispin, Nissim Arbib, Ron Bardin, Arnon Wiznitzer, Eran Hadar
AIMS: To assess the association of gestational weight gain or loss with adverse pregnancy outcome among women with gestational diabetes mellitus (GDM). METHODS: Retrospective study of all women diagnosed with GDM, from July 2012 to December 2016, stratified by gestational weight change according to the institute of medicine recommendations. Primary maternal outcome was glycemic control and primary neonatal outcome was large or small for gestational age (LGA or SGA)...
April 21, 2018: Diabetes Research and Clinical Practice
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