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https://www.readbyqxmd.com/read/29325565/impact-of-social-relationships-on-alzheimer-s-memory-impairment-mechanistic-studies
#1
REVIEW
Ya-Hsin Hsiao, Chih-Hua Chang, Po-Wu Gean
Alzheimer's disease (AD) is characterized by progressive memory and neuronal loss culminating in cognitive impairment that not only affects a person's living ability but also becomes a society's as well as a family's economic burden. AD is the most common form of dementia in older persons. It is expected that the number of people with AD dementia will increase dramatically in the next 30 years, projecting to 75 million in 2030 and 131.5 million in 2050 worldwide. So far, no sufficient evidence is available to support that any medicine is able to prevent or reverse the progression of the disease...
January 11, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29317593/loneliness-5-years-ante-mortem-is-associated-with-disease-related-differential-gene-expression-in-postmortem-dorsolateral-prefrontal-cortex
#2
Turhan Canli, Lei Yu, Xiaoqing Yu, Hongyu Zhao, Debra Fleischman, Robert S Wilson, Philip L De Jager, David A Bennett
Subjective social isolation, loneliness, is associated with poor mental and physical health, but the underlying molecular mechanisms are poorly understood. Here we analyzed loneliness data collected on average 5 years ante-mortem and RNA gene expression at death in postmortem dorsolateral prefrontal cortex (DLPFC) from 181 participants in the Rush Memory and Aging Project (MAP), a longitudinal, prospective cohort study of common chronic conditions of aging. Our analytic protocol controlled for biographical variables (age, sex, education), psychological and health variables (depressive symptoms, interval between assessment and autopsy, slope of cognitive decline, AD pathology, presence of infarcts) and RNA integrity...
January 10, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29315958/what-leads-to-loneliness-an-integrative-model-of-social-motivational-and-emotional-approaches-in-adolescents
#3
Laura O Gallardo, Jose Martín-Albo, Angel Barrasa
Loneliness has been linked to many physical and mental health problems, especially during adolescence. From evolutionary, social needs, and cognitive approaches, this study examined whether emotional repair, relatedness need, and peer-rated indicators of relations behave in predicting loneliness, considering all approaches together. The sample consisted of 373 adolescents measured longitudinally at three time points. Results of a cross-lagged panel design found that, considering all the influences together, relatedness need showed the highest strength to predict loneliness...
January 9, 2018: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/29300416/the-association-between-bmi-and-different-frailty-domains-a-u-shaped-curve
#4
M L Rietman, D L van der A, S H van Oostrom, H S J Picavet, M E T Dollé, H van Steeg, W M M Verschuren, A M W Spijkerman
OBJECTIVES: Previous studies showed a U-shaped association between BMI and (physical) frailty. We studied the association between BMI and physical, cognitive, psychological, and social frailty. Furthermore, the overlap between and prevalence of these frailty domains was examined. DESIGN: Cross-sectional study. SETTING: The Doetinchem Cohort Study is a longitudinal population-based study starting in 1987-1991 examining men and women aged 20-59 with follow-up examinations every 5 yrs...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29300228/loneliness-in-multiple-sclerosis-possible-antecedents-and-correlates
#5
Julia M Balto, Lara A Pilutti, Robert W Motl
PURPOSE: The prevalence and possible antecedents and correlates of loneliness in multiple sclerosis (MS) was examined. DESIGN: Cross-sectional, comparative study of MS (n = 63) and healthy adults (n = 21). METHODS: Data were collected using self-reports of loneliness and antecedents and correlates and analyzed using inferential statistics. FINDINGS: Those with MS had significantly higher loneliness scores than healthy adults (p < ...
January 3, 2018: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
https://www.readbyqxmd.com/read/29202654/sensation-and-psychiatry-linking-age-related-hearing-loss-to-late-life-depression-and-cognitive-decline
#6
Bret R Rutherford, Katharine Brewster, Justin S Golub, Ana H Kim, Steven P Roose
Recent research has linked age-related hearing loss to impaired performance across cognitive domains and increased risk for dementia diagnosis. The data linking hearing impairment to incident late-life depression are more mixed but suggest that diminished hearing does increase risk for depression. Behavioral mechanisms may explain these associations, such as the withdrawal of older adults from situations in which they may have difficulty hearing and communicating, which may contribute to the development of social isolation, loneliness, and consequent cognitive decline and depression...
December 5, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29188485/prospective-associations-of-social-isolation-and-loneliness-with-poor-sleep-quality-in-older-adults
#7
Bin Yu, Andrew Steptoe, Kaijun Niu, Po-Wen Ku, Li-Jung Chen
PURPOSE: There is evidence for negative associations between social isolation and loneliness and sleep quality in older adults. However, it is unclear to what extent these two factors independently affect sleep quality. This study examined the simultaneous associations of social isolation and loneliness with sleep quality in a longitudinal study of older adults. METHODS: Data were analyzed from the Social Environment and Biomarkers of Aging Study in Taiwan collected in 2000 and 2006, involving a cohort of 639 participants (mean age = 66...
November 30, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/29184323/stress-and-stressors-among-medical-undergraduate-students-a-cross-sectional-study-in-a-private-medical-college-in-tamil-nadu
#8
R Anuradha, Ruma Dutta, J Dinesh Raja, P Sivaprakasam, Aruna B Patil
Background: Medical education is perceived as being stressful, and a high level of stress may have a negative effect on cognitive functioning and learning of students in a medical school. Objectives: To (a) assess the perceived stress among medical undergraduate students, (b) identify the sources of stress, and (c) find an association of perceived stress with sociodemographic characteristics and various stressors. Materials and Methods: A cross-sectional study was conducted among medical undergraduate students in a private medical college in Tamil Nadu...
October 2017: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/29130976/discontinued-information-and-communication-technology-usage-among-older-adults-in-continuing-care-retirement-communities-in-the-united-states
#9
R V Rikard, Ronald W Berkowsky, Shelia R Cotten
BACKGROUND: Older adults are increasingly using information and communication technologies (ICTs). Recent studies show beneficial effects of using ICTs for older adults, particularly in terms of reducing loneliness and depression. However, little is known about the factors that may prevent discontinued ICT use in populations that may be at greater risk, such as those in continuing care retirement communities (CCRCs). OBJECTIVES: The purpose of this study is to examine a range of factors that may influence discontinued (1) ICT use, (2) searching for health information, and (3) searching for general information over time among CCRC residents...
November 9, 2017: Gerontology
https://www.readbyqxmd.com/read/29116555/modifiable-correlates-of-perceived-cognitive-function-in-breast-cancer-survivors-up-to-10%C3%A2-years-after-chemotherapy-completion
#10
Ashley Henneghan, Alexa Stuifbergen, Heather Becker, Shelli Kesler, Elisabeth King
BACKGROUND: Cognitive changes following breast cancer treatment are likely multifactorial and have been linked to emotional factors, biophysiological factors, and fatigue, among others. Little is known about the contributions of modifiable factors such as stress, loneliness, and sleep quality. The purpose of this study was to explore the direct and indirect effects of perceived stress, loneliness, and sleep quality on perceived cognitive function (PCF) in breast cancer survivors (BCS) after chemotherapy completion...
November 7, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29102150/it-is-all-in-their-mind-a-review-on-information-processing-bias-in-lonely-individuals
#11
REVIEW
Annette W M Spithoven, Patricia Bijttebier, Luc Goossens
Loneliness is a distressing emotional state that motivates individuals to renew and maintain social contact. It has been suggested that lonely individuals suffer from a cognitive bias towards social threatening stimuli. However, current models of loneliness remain vague on how this cognitive bias is expressed in lonely individuals. The current review provides an up-to-date overview of studies examining loneliness in relation to various aspects of cognitive functioning. These studies are interpreted in light of the Social Information Processing (SIP) model...
December 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/29100718/-programs-to-combat-loneliness-in-the-institutionalised-elderly-a-review-of-the-scientific-literature
#12
Ana Isabel Bermeja, Berta Ausín
Loneliness is a problem that affects a very high percentage of older people, and can lead to physical and/or mental illness. This article aims to present a systematic review of programs to combat loneliness directed towards the institutionalised elderly. Experimental and quasi-experimental articles published between 2000 and 2016 were included in the review. An analysis was carried out on the quality of the methodological evidence of each of the articles. The programs analysed included animal-assisted, contacts with families through videoconferencing, gardening and/or horticulture workshops, reminiscence therapies, humour therapies, and cognitive interventions...
October 31, 2017: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/29069628/still-lonely-social-adjustment-of-youth-with-and-without-social-anxiety-disorder-following-cognitive-behavioral-therapy
#13
Cynthia Suveg, Julie Newman Kingery, Molly Davis, Anna Jones, Monica Whitehead, Marni L Jacob
Social experiences are an integral part of normative development for youth and social functioning difficulties are related to poor outcomes. Youth with anxiety disorders, and particularly social anxiety disorder, experience difficulties across many aspects of social functioning that may place them at risk for maladjustment. The goal of this paper was to compare social experiences of youth across anxiety diagnoses and examine whether treatment is helpful in improving social functioning. Ninety-two children (age 7-12 years; 58% male; 87...
December 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29030910/the-role-of-general-psychosocial-factors-for-the-use-of-cancer-screening-findings-of-a-population-based-observational-study-among-older-adults-in-germany
#14
André Hajek, Jens-Oliver Bock, Hans-Helmut König
Within the framework of the health-belief model, some studies exist investigating the association between illness-specific psychosocial factors and the use of cancer screenings. However, studies investigating the association between general psychosocial factors and the use of cancer screenings are missing. Thus, this study aimed at examining the association between well-established general psychosocial factors and the use of cancer screenings. Data were gathered from a large, population-based sample of community-dwelling individuals aged 40 and above in Germany (n = 7673; in 2014)...
October 13, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28985256/does-current-smoking-predict-future-frailty-the-english-longitudinal-study-of-ageing
#15
Gotaro Kojima, Steve Iliffe, Stephen Jivraj, Ann Liljas, Kate Walters
Background: smoking is the single most preventable cause of morbidity and mortality. The evidence on independent associations between smoking in later life and incident frailty is scarce. Objectives: to examine the effect of current smoking in older people on the risk of developing frailty, controlling for important confounders. Methods: we used data of 2,542 community-dwelling older people aged ≥60 years in England. Participants were classified as current smokers or non-smokers...
August 17, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28983735/cancer-related-loneliness-mediates-the-relationships-between-social-constraints-and-symptoms-among-cancer-patients
#16
Rebecca N Adams, Catherine E Mosher, Joseph G Winger, Rafat Abonour, Kurt Kroenke
Cancer patients have high rates of persistent and disabling symptoms. Evidence suggests that social constraints (e.g., avoidance and criticism) negatively impact symptoms, but pathways linking these variables have yet to be identified. This study examined whether cancer-related loneliness (i.e., feeling socially disconnected related to having cancer) mediated the relationships between social constraints and symptoms (i.e., pain interference, fatigue, sleep disturbance, and cognitive complaints) in patients with various cancers (N = 182)...
October 5, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28913913/development-of-the-cancer-related-loneliness-assessment-tool-using-the-findings-of-a-qualitative-analysis-to-generate-questionnaire-items
#17
K B Cunningham, T Kroll, M Wells
The aim of this research was to develop a tool to identify and assess the qualities of cancer-related loneliness in adult cancer survivors who have completed treatment. In addition to reporting the development of the tool, we explicate the process of using the findings of a qualitative analysis to generate questionnaire items, as currently little guidance exists on this topic. The findings of our qualitative research exploring the experience of loneliness in adult cancer survivors who had completed treatment, together with the findings of our concept analysis of loneliness, were used to develop an assessment tool for cancer-related loneliness following treatment completion...
September 15, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28895503/needs-assessment-with-elder-syrian-refugees-in-lebanon-implications-for-services-and-interventions
#18
Zeina Chemali, Christina P C Borba, Kelsey Johnson, Sama Khair, Gregory L Fricchione
Currently, over 1 million Syrian and Palestinian refugees have fled Syria to take refuge in Lebanon. Among this vulnerable population, elder refugees warrant particular concern, as they shoulder a host of additional health and safety issues that require additional resources. However, the specific needs of elder refugees are often overlooked, especially during times of crisis. Our study used a semi-structured interview to survey the needs of elder refugees and understand their perceived support from Lebanese fieldworkers...
September 12, 2017: Global Public Health
https://www.readbyqxmd.com/read/28862676/problems-in-classifying-mild-cognitive-impairment-mci-one-or-multiple-syndromes
#19
María Del Carmen Díaz-Mardomingo, Sara García-Herranz, Raquel Rodríguez-Fernández, César Venero, Herminia Peraita
As the conceptual, methodological, and technological advances applied to dementias have evolved the construct of mild cognitive impairment (MCI), one problem encountered has been its classification into subtypes. Here, we aim to revise the concept of MCI and its subtypes, addressing the problems of classification not only from the psychometric point of view or by using alternative methods, such as latent class analysis, but also considering the absence of normative data. In addition to the well-known influence of certain factors on cognitive function, such as educational level and cultural traits, recent studies highlight the relevance of other factors that may significantly affect the genesis and evolution of MCI: subjective memory complaints, loneliness, social isolation, etc...
September 1, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28854882/a-four-domain-approach-of-frailty-explored-in-the-doetinchem-cohort-study
#20
Sandra H van Oostrom, Daphne L van der A, M Liset Rietman, H Susan J Picavet, Manon Lette, W M Monique Verschuren, Simone R de Bruin, Annemieke M W Spijkerman
BACKGROUND: Accumulation of problems in physical, psychological, cognitive, or social functioning is characteristic for frail individuals. Using a four-domain approach of frailty, this study explored how sociodemographic and lifestyle factors, life events and health are associated with frailty. METHODS: The study sample included 4019 men and women (aged 40-81 years) examined during the fifth round (2008-2012) of the Doetinchem Cohort Study. Four domains of frailty were considered: physical (≥4 of 8 criteria: unintentional weight loss, exhaustion, strength, perceived health, walking, balance, hearing and vision impairments), psychological (2 criteria: depressive symptoms, mental health), cognitive (<10th percentile on global cognitive functioning), and social frailty (≥2 of 3 criteria: loneliness, social support, social participation)...
August 30, 2017: BMC Geriatrics
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