keyword
https://read.qxmd.com/read/38493832/efficacy-and-safety-of-aficamten-in-symptomatic-non-obstructive-hypertrophic-cardiomyopathy-results-from-the-redwood-hcm-trial-cohort-4
#21
JOURNAL ARTICLE
Ahmad Masri, Mark V Sherrid, Theodore P Abraham, Lubna Choudhury, Pablo Garcia-Pavia, Christopher M Kramer, Roberto Barriales-Villa, Anjali T Owens, Florian Rader, Sherif F Nagueh, Iacopo Olivotto, Sara Saberi, Albree Tower-Rader, Timothy C Wong, Caroline J Coats, Hugh Watkins, Michael A Fifer, Scott D Solomon, Stephen B Heitner, Daniel L Jacoby, Stuart Kupfer, Fady I Malik, Lisa Meng, Regina L Sohn, Amy Wohltman, Martin S Maron
BACKGROUND: This open-label phase 2 trial evaluated the safety and efficacy of aficamten in patients with non-obstructive hypertrophic cardiomyopathy (nHCM). METHODS: Patients with symptomatic nHCM (left ventricular outflow tract obstruction gradient ≤30 mmHg, left ventricular ejection fraction [LVEF] ≥60%, N-terminal pro-B-type natriuretic peptide [NT-proBNP] >300 pg/mL) received aficamten 5-20 mg once daily (doses adjusted according to echocardiographic LVEF) for 10 weeks...
March 15, 2024: Journal of Cardiac Failure
https://read.qxmd.com/read/38492771/racial-differences-in-palliative-care-use-in-heart-failure-decedents
#22
JOURNAL ARTICLE
Sarah H Cross, Neal W Dickert, Alanna A Morris, Jabeen Taj, Modele O Ogunniyi, Dio Kavalieratos
BACKGROUND: Minoritized individuals experience greater heart failure (HF) incidence and mortality, yet racial disparities in palliative care (PC) in HF are unknown. METHODS: This retrospective study used electronic medical records to identify adults who were hospitalized at an academic health system and died from HF between 2012-2018. Using multivariable logistic regression, we examined associations between decedent characteristics and PC consultations (PCC). RESULTS: Of 1,987 decedents, 45...
March 14, 2024: Journal of Cardiac Failure
https://read.qxmd.com/read/38492770/the-pandemic-that-never-left
#23
JOURNAL ARTICLE
Abdul Mannan Khan Minhas, Marat Fudim, Dmitry Abramov
No abstract text is available yet for this article.
March 14, 2024: Journal of Cardiac Failure
https://read.qxmd.com/read/38491822/the-carbon-monoxide-prodrug-ocom-21-increases-ca-2-sensitivity-of-the-cardiac-myofilament
#24
JOURNAL ARTICLE
Fergus M Payne, Samantha Nie, Gary M Diffee, Gerard T Wilkins, David S Larsen, Joanne C Harrison, James C Baldi, Ivan A Sammut
Patients undergoing cardiopulmonary bypass procedures require inotropic support to improve hemodynamic function and cardiac output. Current inotropes such as dobutamine, can promote arrhythmias, prompting a demand for improved inotropes with little effect on intracellular Ca2+ flux. Low-dose carbon monoxide (CO) induces inotropic effects in perfused hearts. Using the CO-releasing pro-drug, oCOm-21, we investigated if this inotropic effect results from an increase in myofilament Ca2+ sensitivity. Male Sprague Dawley rat left ventricular cardiomyocytes were permeabilized, and myofilament force was measured as a function of -log [Ca2+ ] (pCa) in the range of 9...
March 2024: Physiological Reports
https://read.qxmd.com/read/38490900/diagnosis-and-management-of-vasoplegia-in-temporary-mechanical-circulatory-support-a-narrative-review
#25
REVIEW
Jamel Ortoleva, Adam A Dalia, Dominic V Pisano, Alexander Shapeton
Refractory vasodilatory shock, or vasoplegia, is a pathophysiologic state observed in the intensive care unit and operating room in patients with a variety of primary diagnoses. Definitions of vasoplegia vary by source but are qualitatively defined clinically as a normal or high cardiac index and low systemic vascular resistance causing hypotension despite high-dose vasopressors in the setting of euvolemia. This definition can be difficult to apply to patients undergoing mechanical circulatory support (MCS)...
February 23, 2024: Journal of Cardiothoracic and Vascular Anesthesia
https://read.qxmd.com/read/38489694/effect-of-liraglutide-on-cardiac-function-in-patients-with-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis-of-double-blind-randomized-placebo-controlled-trials
#26
JOURNAL ARTICLE
Wenjing Xia, Hua Yu, Xia Lei, Pengcheng Wen
BACKGROUND: Liraglutide widely utilized in type 2 diabetes treatment, has elicited conflicting findings regarding its impact on cardiac function in patients with this condition. Therefore, The objective of this study was to conduct a meta-analysis of randomized controlled trials (RCTs) to evaluate the effects of liraglutide on cardiac function in patients diagnosed with type 2 diabetes. METHODS: We identified double-blind randomized trials assessing the effects of liraglutide compared to placebo on cardiac function in patients with type 2 diabetes...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38485295/cognitive-impairment-in-heart-failure-a-heart-failure-society-of-america-scientific-statement
#27
REVIEW
Parag Goyal, Robert J Didomenico, Susan J Pressler, Chinwe Ibeh, Connie White-Williams, Larry A Allen, Eiran Z Gorodeski
Cognitive impairment is common among adults with heart failure (HF), as both diseases are strongly related to advancing age and multimorbidity (including both cardiovascular and noncardiovascular conditions). Moreover, HF itself can contribute to alterations in the brain. Cognition is critical for a myriad of self-care activities that are necessary to manage HF, and it also has a major impact on prognosis; consequently, cognitive impairment has important implications for self-care, medication management, function and independence, and life expectancy...
March 2024: Journal of Cardiac Failure
https://read.qxmd.com/read/38485294/cognitive-impairment-is-our-job-too
#28
EDITORIAL
Eiran Z Gorodeski, Parag Goyal
No abstract text is available yet for this article.
March 2024: Journal of Cardiac Failure
https://read.qxmd.com/read/38479593/evaluation-of-the-translation-of-multiple-cardiovascular-regulatory-mechanisms-in-the-anesthetized-dog
#29
JOURNAL ARTICLE
Olivera Antic, Yevgeniya E Koshman, Brandan M Bird, Geena Jasiek, Amanda S Wilsey, Scott W Mittelstadt, C Michael Foley
The strategic and targeted use of an anesthetized canine cardiovascular model early in drug discovery enables a comprehensive cardiovascular and electrophysiological assessment of potential safety liabilities and guides compound selection prior to initiation of chronic toxicological studies. An ideal model would enable exposure-response relationships to guide safety margin calculations, have a low threshold to initiate, and have quick delivery of decision quality data. We have aimed to profile compounds with diverse mechanism of actions (MoAs) of "non-QT" cardiovascular drug effects and evaluate the ability of nonclinical in vivo cardiovascular models to detect clinically reported effects...
March 11, 2024: Journal of Pharmacological and Toxicological Methods
https://read.qxmd.com/read/38479576/pitfalls-and-opportunities-for-the-growing-role-of-ai-in-heart-failure
#30
JOURNAL ARTICLE
Jagpreet S Grewal, Partho P Sengupta
No abstract text is available yet for this article.
March 11, 2024: Journal of Cardiac Failure
https://read.qxmd.com/read/38460671/capturing-the-evolving-landscape-of-primary-graft-dysfunction-after-heart-transplantation-will-achilles-ever-overtake-the-tortoise
#31
JOURNAL ARTICLE
Melana Yuzefpolskaya, Paolo C Colombo
No abstract text is available yet for this article.
March 7, 2024: Journal of Cardiac Failure
https://read.qxmd.com/read/38460670/synergy-not-silos-the-intersection-of-medical-and-surgical-training-in-advanced-heart-failure
#32
JOURNAL ARTICLE
Jenna Skowronski, Alexander G Hajduczok, Laura DiChiacchio
No abstract text is available yet for this article.
March 7, 2024: Journal of Cardiac Failure
https://read.qxmd.com/read/38458486/cardiogenic-shock-intravascular-cooling-trial-chill-shock
#33
JOURNAL ARTICLE
Nikhil Gupta, Rohan J Kalathiya, Nikhil Singh, Nadeem Bandealy, Maryam Neyestanak, Stephanie Besser, Cynthia Arevalo, Janet Friant, John Ea Blair, Sandeep Nathan, Atman P Shah, Jonathan Paul
BACKGROUND: Cardiogenic shock (CS) is complicated by high mortality. Targeted temperature control (TTC) has been proposed as an adjunct therapy in CS. This study aims to examine the safety of TTC in patients presenting with CS. METHODS AND RESULTS: In this open label, randomized controlled pilot trial, 20 patients with hemodynamic criteria for CS were assigned to standard of care plus TTC vs. standard of care alone. The primary outcome was a composite safety outcome including well described complications of TTC...
March 6, 2024: Journal of Cardiac Failure
https://read.qxmd.com/read/38458485/poor-medication-access-as-a-driver-of-excess-heart-failure-readmissions-among-patients-living-in-economically-deprived-neighborhoods
#34
JOURNAL ARTICLE
Apoorva Gangavelli, Zihao Liu, Jeffrey Wang, Alexis Okoh, Rebecca S Steinberg, Krishan Patel, Shivani A Patel, Neal W Dickert, Alanna A Morris
BACKGROUND: Patients residing in socioeconomically deprived neighborhoods experience higher hospital readmission following hospitalization for heart failure (HF). The role of medication access in these excess readmissions in this group is poorly understood. This study explored patient perspectives on medication access among individuals living in socioeconomically deprived neighborhoods who had experienced HF readmission. METHODS: We conducted semi-structured in-depth interviews with 25 patients (mean age 61 ± 9 years, 96% Black, 40% women) readmitted with acute HF at Emory Healthcare hospitals and living in highly deprived neighborhoods (top decile of the Social Deprivation Index)...
March 6, 2024: Journal of Cardiac Failure
https://read.qxmd.com/read/38458484/temporal-outcomes-of-patients-diagnosed-with-transthyretin-cardiac-amyloidosis
#35
JOURNAL ARTICLE
Nicholas Chan, Sergio Teruya, Alfonsina Mirabal, Ariel Y Weinsaft, Jeffeny De Los Santos, Samantha Guadalupe, Massiel Jimenez, Carlos Rodriguez, Stephen Helmke, Margaret Cuomo, Dia Smiley, Mathew S Maurer
BACKGROUND: Transthyretin cardiac amyloidosis (ATTR-CA) is increasingly recognized. Clinical outcomes have evolved over time amidst changes in the diagnostic pathway and advances in therapeutics. OBJECTIVE: To evaluate clinical outcomes over time of ATTR-CA patients with access to disease-modifying therapy. METHODS: This is a retrospective cohort study of 419 patients diagnosed with ATTR-CA during 2001-2021, comparing clinical characteristics across eras...
March 6, 2024: Journal of Cardiac Failure
https://read.qxmd.com/read/38453571/acute-heart-failure-an-efim-guideline-critical-appraisal-and-adaptation-for-internists
#36
JOURNAL ARTICLE
Valentin A Kokorin, Alvaro González-Franco, Antonio Cittadini, Oskars Kalejs, Vera N Larina, Alberto M Marra, Francisco J Medrano, Zdenek Monhart, Laura Morbidoni, Joana Pimenta, Wiktoria Lesniak
BACKGROUND: Over the past two decades, several studies have been conducted that have tried to answer questions on management of patients with acute heart failure (AHF) in terms of diagnosis and treatment. Updated international clinical practice guidelines (CPGs) have endorsed the findings of these studies. The aim of this document was to adapt recommendations of existing guidelines to help internists make decisions about specific and complex scenarios related to AHF. METHODS: The adaptation procedure was to identify firstly unresolved clinical problems in patients with AHF in accordance with the PICO (Population, Intervention, Comparison and Outcomes) process, then conduct a critical assessment of existing CPGs and choose recommendations that are most applicable to these specific scenarios...
March 6, 2024: European Journal of Internal Medicine
https://read.qxmd.com/read/38452999/wearable-sensors-to-monitor-physical-activity-in-heart-failure-clinical-trials-state-of-the-art-review
#37
REVIEW
Ruben Buendia, Martin Karpefors, Folke Folkvaljon, Robert Hunter, Henrik Sillen, Long Luu, Kieran Docherty, Martin R Cowie
BACKGROUND: Estimation of the effect that a drug or other intervention has on patient symptoms and functions is crucial in heart failure trials. Traditional symptoms and functions clinical outcome assessments have important limitations. Actigraphy may help to overcome these limitations due to its objective nature and the potential for continuous recording of data. However, actigraphy is not currently accepted as clinically relevant by key stakeholders. METHODS AND RESULTS: In this This State-of-the-Art paper, the key aspects to consider when implementing actigraphy in heart failure trials are discussed...
March 5, 2024: Journal of Cardiac Failure
https://read.qxmd.com/read/38452998/unmasking-hfpef-with-artificial-intelligence-a-disruptive-opportunity-for-disease-detection
#38
JOURNAL ARTICLE
Amogh Karnik, Madeline Jankowski, Akhil Narang
No abstract text is available yet for this article.
March 5, 2024: Journal of Cardiac Failure
https://read.qxmd.com/read/38452997/leveraging-the-full-potential-of-wearable-devices-in-cardiomyopathies
#39
JOURNAL ARTICLE
Evangelos K Oikonomou, Rohan Khera
No abstract text is available yet for this article.
February 29, 2024: Journal of Cardiac Failure
https://read.qxmd.com/read/38452996/achieving-consensus-severity-graded-definitions-of-fontan-associated-complications-to-characterize-fontan-circulatory-failure
#40
JOURNAL ARTICLE
Kurt R Schumacher, Ari Cedars, Kiona Allen, David Goldberg, Adrianna Batazzi, Garrett Reichle, Frank DiPaola, David Selewski, Melissa Cousino, David N Rosenthal
BACKGROUND: Fontan physiology leads to chronic changes in other organ systems that may affect long-term survival and the success of heart transplantation. Inadequate assessment and treatment of the extra-cardiac effects of Fontan may contribute to poor outcomes. Severity graded/ordinal consensus definitions of Fontan complications are lacking which limits understanding of how Fontan-specific morbidity affects patient outcomes. METHODS AND RESULTS: A panel of Fontan patient and physiology experts, including pediatric, adult congenital, heart failure, and critical care cardiology, and pediatric nephrology, hepatology and psychology, convened to develop definitions of Fontan complications...
March 5, 2024: Journal of Cardiac Failure
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