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https://www.readbyqxmd.com/read/28073074/tribocorrosion-behavior-of-bio-functionalized-highly-porous-titanium
#1
F Toptan, A C Alves, A M P Pinto, P Ponthiaux
Titanium and its alloys are widely used in orthopedic and dental implants, however, some major clinical concerns such as poor wear resistance, lack of bioactivity, and bone resorption due to stress shielding are yet to be overcome. In order to improve these drawbacks, highly porous Ti samples having functionalized surfaces were developed by powder metallurgy with space holder technique followed by anodic treatment. Tribocorrosion tests were performed in 9g/L NaCl solution using a unidirectional pin-on-disc tribometer under 3N normal load, 1Hz frequency and 4mm track diameter...
January 4, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28069415/silymarin-exerts-antifungal-effects-via-membrane-targeted-mode-of-action-by-increasing-permeability-and-inducing-oxidative-stress
#2
Dae Gyu Yun, Dong Gun Lee
Silymarin, which is derived from the seeds of Silybum marianum, has been widely used to prevent and treat liver disorders. It is also consumed as a dietary supplement to improve liver function, as it does not exhibit any toxic effects in humans. Recently, silymarin has been reported to show antimicrobial effects against various pathogenic microorganisms, but the mode of action remains unknown. Thus, we investigated the antifungal activity of silymarin and aimed to determine the underlying mechanism. Initially, a propidium iodide assay was carried out; the results indicated that silymarin induced injury to the fungal plasma membrane...
January 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28064138/ultrasensitive-photoacoustic-sensor-based-on-quantum-cascade-laser-spectroscopy
#3
Deepak Kumar, Surya Gautam, Subodh Kumar, Saurabh Gupta, Hari B Srivastava, Surya N Thakur, Ramesh C Sharma
The paper focuses on development of ultra-sonic detection system based on laser photoacoustic spectroscopic technique and processing of signal for detection of very low quantity chemicals, explosive materials, and mixtures of these hazardous molecules. The detection system has been developed for the first time with specially designed one side open photo-acoustic cell having high quality factor. Explosive and Hazardous materials like RDX, DNT, PETN, Gun Powder, TATP (Tri acetone tri-peroxide) and their simulants like Acetone were detected in 7 to 9μm wavelength band...
November 23, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28058592/parallel-spectral-acquisition-with-orthogonal-icr-cells
#4
Sung-Gun Park, Gordon A Anderson, James E Bruce
FT-based high performance mass analyzers yield increased resolving power and mass measurement accuracy, yet require increased duration of signal acquisition that can limit many applications. The implementation of stronger magnetic fields, multiple detection electrodes for harmonic signal detection, and an array of multiple mass analyzers arranged along the magnetic field axis have been used to decrease required acquisition time. The results presented here show that multiple ion cyclotron resonance (ICR) mass analyzers can also be implemented orthogonal to the central magnetic field axis...
January 5, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28040564/role-of-potassium-channels-in-chlorogenic-acid-induced-apoptotic-volume-decrease-and-cell-cycle-arrest-in-candida-albicans
#5
JiEun Yun, Dong Gun Lee
BACKGROUND: Chlorogenic acid (CRA) is an abundant phenolic compound in the human diet. CRA has a potent antifungal effect, inducing cell death in Candida albicans. However, there are no further studies to investigate the antifungal mechanism of CRA, associated with ion channels. METHODS: To evaluate the inhibitory effects on CRA-induced cell death, C. albicans cells were pretreated with potassium and chloride channel blockers, separately. Flow cytometry was carried out to detect several hallmarks of apoptosis, such as cell cycle arrest, caspase activation, and DNA fragmentation, after staining of the cells with SYTOX green, FITC-VAD-FMK, and TUNEL...
December 28, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27955825/possession-of-weapon-and-school-violence-among-adolescents-and-their-association-with-history-of-traumatic-brain-injury-substance-use-and-mental-health-issues
#6
Gabriela Ilie, Robert E Mann, Angela Boak, Hayley A Hamilton, Jürgen Rehm, Michael D Cusimano
PURPOSE: Assessment of the association between illegal possession of weapon and assault on school property among adolescents with and without a history of traumatic brain injury (TBI) while assessing risk factors for these outcomes. METHODS: Data were derived from the Centre for Addiction and Mental Health's 2013 Ontario Student Drug Use and Health Survey completed by students in grades 7-12 (ages 11-20). RESULTS: In this sample of 5478 adolescents, 6...
September 16, 2016: Injury
https://www.readbyqxmd.com/read/27873295/colleges-and-universities-sticking-to-their-guns
#7
Jesse Perez Mendez, Lou Sabina, Jon Loffi
Firearm possession on college and university campuses remains a volatile public policy issue among policymakers, legislators, scholars, and administrators. Given the American federal governmental structure, many states have developed legislative approaches to "carry on campus" policies throughout the years that align with federal law. This study explores the diversity of state approaches and nuances of "carry on campus" throughout recent years and current state legislation under consideration. The implications of "carry on campus" legislation vary on college campuses, depending on applicable state law; however, some general dynamics apply to all...
September 2016: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/27865616/phenylpropanoids-from-cinnamon-bark-reduced-%C3%AE-amyloid-production-by-the-inhibition-of-%C3%AE-secretase-in-chinese-hamster-ovarian-cells-stably-expressing-amyloid-precursor-protein
#8
Yu Jeong Kang, Dae-Gun Seo, So-Young Park
β-Amyloid (Aβ) is a substance of Alzheimer disease (AD), which is generated via the amyloidogenic pathway from amyloid precursor protein (APP) by β-secretase and γ-secretase. Inhibition of Aβ production is a potential therapeutic approach to AD. Thus, we tested the hypothesis that cinnamon bark (Cinnamomi Cortex Spissus), the dried bark of Cinnamomum cassia Blume (Lauraceae), and its constituents are beneficial to AD. The methanol extract of cinnamon bark efficiently reduced Aβ40 production in Chinese hamster ovarian (CHO) cells stably expressing APP as determined by enzyme-linked immunosorbent assay...
November 2016: Nutrition Research
https://www.readbyqxmd.com/read/27793475/biochemical-analysis-of-recombinant-cyp4a11-allelic-variant-enzymes-w126r-k276t-and-s353g
#9
Songhee Han, Gun-Su Cha, Young-Jin Chun, Chang Hoon Lee, Donghak Kim, Chul-Ho Yun
Human CYP4A11 is the major ω-hydroxylase of fatty acids in the liver and kidneys. It produces 20-hydroxyeicosatetraenoic acid as well as hydroxylates fatty acids. In this study, we investigated the biochemical properties of three alleles of CYP4A11: W126R, K276T, and S353G. Site-directed mutagenesis of the wild type CYP4A11 was performed, to construct the W126R, K276T, and S353G variant clones. The CYP4A11 wild type and variant constructs were heterologously expressed in Escherichia coli. CO-binding spectra showed the expression of the wild type, K276T and S353G variants, indicating the functional P450 holoenzyme...
December 2016: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/27622112/pediatric-arm-reconstruction-after-shot-gun-injury-using-peroneal-free-flap-and-pedicled-latissimus-dorsi-muscle-flap-late-follow-up
#10
Carlos Olvera-Caballero, Abel Ortiz-Dominguez
A 15-year-old patient harmed himself upon firing a shotgun that he was carrying when he slipped and fell, causing a destructive wound in the right arm with a medial entry hole and a posterolateral exit hole. The biceps, coracobrachialis, triceps, deltoids, skin cover, and humerus were injured; however, the blood vessels and major nerves of the area were surprisingly not affected. The residual skin muscle defect after debridements was 16 × 5 cm medially and posteriorly, and the bone loss was 7 cm. The wound was reconstructed during a single surgery with a free fibula flap and a pedicled flap of latissimus dorsi...
August 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27601685/abatement-of-particulate-matter-emission-from-experimental-aviary-housings-for-laying-hens-by-spraying-rapeseed-oil
#11
A Winkel, J W van Riel, R A van Emous, A J A Aarnink, P W G Groot Koerkamp, N W M Ogink
In alternative systems for laying hens, concentrations and emission rates of particulate matter (PM) give reason for concern with regard to working conditions, bird health and productivity, and health of residents living near farms. Previously, we found that spraying a film of rapeseed oil onto the litter of broilers could substantially reduce PM concentrations and emissions. The objective of this study was to establish dose-response effects of oil spraying in aviaries on concentrations and emission rates of PM with aerodynamic diameters less than 10 μm (PM10) and 2...
December 1, 2016: Poultry Science
https://www.readbyqxmd.com/read/27417128/insulin-pump-therapy-in-children-with-type-1-diabetes-analysis-of-data-from-the-sweet-registry
#12
Agnieszka Szypowska, Anke Schwandt, Jannet Svensson, Shlomit Shalitin, Roque Cardona-Hernandez, Gun Forsander, Frida Sundberg, Carine De Beaufort, David Maahs, Claudio Maffeis, Stephen M P O'Riordan, Iveta Dzivite Krisane, Mauro Scharf, Sofia Castro, Maia Konstantinova, Barbora Obermannova, Kristina Casteels, Damla Gökşen, Júlia Galhardo, Christina Kanaka-Gantenbein, Birgit Rami-Merhar, Laszlo Madacsy
BACKGROUND: Intensified insulin delivery using multiple daily injections (MDI) or continuous subcutaneous insulin infusion (CSII) is recommended in children with type 1 diabetes (T1D) to achieve good metabolic control. OBJECTIVE: To examine the frequency of pump usage in T1D children treated in SWEET (Better control in Paediatric and Adolescent diabeteS: Working to crEate CEnTers of Reference) centers and to compare metabolic control between patients treated with CSII vs MDI...
October 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/27413324/oral-azithromycin-versus-its-combination-with-miltefosine-for-the-treatment-of-experimental-old-world-cutaneous-leishmaniasis
#13
Eglal I Amer, Maha M Eissa, Shereen F Mossallam
Leishmaniasis is one of the neglected infectious diseases included in the World Health Organization's list of the top guns of antimicrobial resistance. Miltefosine is the first and the only available oral effective therapy for leishmaniasis. For fear of its potential resistance, identification of alternative, effective and safe drugs is urgently needed. Therefore, in view of azithromycin promising activity against a number of Leishmania species, this work was carried out to evaluate the efficacy of oral azithromycin alone versus its combination with miltefosine against experimental Old World Cutaneous leishmaniasis thus, can provide another alternative oral therapy or for the first time an oral combination therapy for leishmaniasis...
June 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27411912/abducens-nerve-palsy-as-a-postoperative-complication-of-minimally-invasive-thoracic-spine-surgery-a-case-report
#14
Luiz Henrique Dias Sandon, Gun Choi, EunSoo Park, Hyung-Chang Lee
BACKGROUND: Thoracic disc surgeries make up only a small number of all spine surgeries performed, but they can have a considerable number of postoperative complications. Numerous approaches have been developed and studied in an attempt to reduce the morbidity associated with the procedure; however, we still encounter cases that develop serious and unexpected outcomes. CASE PRESENTATION: This case report presents a patient with abducens nerve palsy after minimally invasive surgery for thoracic disc herniation with an intraoperative spinal fluid fistula...
July 13, 2016: BMC Surgery
https://www.readbyqxmd.com/read/27356412/-development-and-application-of-jingcen-dy-1-spraying-tanker-for-oncomelania-hupensis-snail-control
#15
Jia-song Wang, Liang-cai He, Xian-bing Rong, Mei-zhi Yuan, Min Wang, Ke-jun Wang, Ya-dong Zhou, Ke- qing Tian, Xiao-feng Zhang
OBJECTIVE: To develop a Jingcen DY-1 type spraying tanker for Oncomelania hupensis snail control and evaluate its effect of field application as well as the cost. METHODS: The currently available tractor was used as a vector, and the mechanical and electrical equipments and containers were integrated with shafts, pipelines and electric lines to produce a spraying tanker for snail control, with the functions of carrying people and molluscicides, generating electric power and getting water, mixing stocking solutions, adjusting molluscicide solutions evenly, and spraying drugs...
February 2016: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/27353507/security-personnel-practices-and-policies-in-u-s-hospitals-findings-from-a-national-survey
#16
Ashley L Schoenfisch, Lisa A Pompeii
Concerns of violence in hospitals warrant examination of current hospital security practices. Cross-sectional survey data were collected from members of a health care security and safety association to examine the type of personnel serving as security in hospitals, their policies and practices related to training and weapon/restraint tool carrying/use, and the broader context in which security personnel work to maintain staff and patient safety, with an emphasis on workplace violence prevention and mitigation...
June 27, 2016: Workplace Health & Safety
https://www.readbyqxmd.com/read/27245809/characteristics-of-youth-with-combined-histories-of-violent-behavior-suicidal-ideation-or-behavior-and-gun-carrying
#17
Joseph E Logan, Kevin J Vagi, Deborah Gorman-Smith
BACKGROUND: Youth reporting combined histories of nonfatal violence, suicidal ideation/behavior, and gun-carrying (VSG) are at risk for perpetrating fatal interpersonal violence and self-harm. AIMS: We characterized these youth to inform prevention efforts. METHOD: We analyzed 2004 data from 3,931 seventh-, ninth-, and 11-12th-grade youth and compared VSG youth (n = 66) with non-gun carrying youth who either had no histories of violence or suicidal thoughts/behavior (n = 1,839), histories of violence (n = 884), histories of suicidal thoughts/behaviors (n = 552), or both (n = 590)...
November 2016: Crisis
https://www.readbyqxmd.com/read/27192640/combined-external-endoscopic-endonasal-assisted-removal-of-a-nail-gun
#18
Puya Dehgani Mobaraki, Fabrizio Longari, Ruggero Lapenna, Giampietro Ricci
Management of penetrating trauma to the paranasal sinuses with retained foreign bodies represents a challenge due to the proximity to vital neurovascular structures. The authors report the successful treatment of a patient with a work-related nail gun injury, carried out by means of a combined endoscopic endonasal external assisted procedure.A transnasal endoscopic approach was planned to minimize inadvertent movements of the nail during surgery and in case necessary to repair the orbit or skull base. No major bleeding or neurovascular complication was observed after surgery and a computed tomography scan was performed after surgery confirming the complete removal of the nail and with no damage of the orbit nor the skull base...
June 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27176665/adolescent-gun-violence-prevention-what-we-know-and-what-we-can-do-to-keep-young-people-safe
#19
Nancy A Dodson
PURPOSE OF REVIEW: This review will focus on recent research, initiatives, and legislation regarding the issue of gun violence as it pertains to adolescents. RECENT FINDINGS: Homicide and suicide continue to be major killers of adolescents in the United States. Gun homicide kills teens in the most urban areas of the United States at the same rate as suicide kills teens in the most rural areas of the United States. Research on assault-injured youth sheds light on risk factors for teen gun homicide, and has found high rates of illegal gun carrying and retaliatory attitudes among at-risk teens...
August 2016: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/27170390/pathogenesis-diagnosis-and-treatment-of-hemochromatosis
#20
Heinz Zoller, Benjamin Henninger
Hemochromatosis is a common cause of chronic liver disease and HFE genotyping allows decisive and non-invasive diagnosis. Molecular and clinical genetic studies have led to the identification of genes other than HFE in patients with inherited diseases associated with increased hepatic iron storage that can cause hemochromatosis, which adds complexity to a diagnostic approach to patients with suspected hemochromatosis. Despite major advances in genetics, hepatic iron quantification by non-invasive methods therefore remains the key to the diagnosis of hemochromatosis...
2016: Digestive Diseases
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