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https://www.readbyqxmd.com/read/28815835/patient-education-materials-assessment-tool-for-laryngectomy-health-information
#1
Kevin Wong, Amir Gilad, Michael B Cohen, Diana N Kirke, Scharukh M Jalisi
BACKGROUND: The decision to undergo laryngectomy carries medical, social, and emotional consequences. This study evaluates the understandability and actionability of current laryngectomy information. METHODS: Laryngectomy-related educational materials from an online search were evaluated using the validated Patient Education Materials Assessment Tool (PEMAT). Reading difficulty was calculated using the Flesch-Kincaid Level, Flesch Reading Ease, Gunning-Fog Index (GFI), Coleman-Liau Index, Automated Readability Index, and Simple Measure of Gobbledygook (SMOG) score...
August 16, 2017: Head & Neck
https://www.readbyqxmd.com/read/28706004/feedback-microtubule-control-and-microtubule-actin-cross-talk-in-arabidopsis-revealed-by-integrative-proteomic-and-cell-biology-analysis-of-katanin-1-mutants
#2
Tomáš Takáč, Olga Šamajová, Tibor Pechan, Ivan Luptovčiak, Jozef Šamaj
Microtubule organization and dynamics are critical for key developmental processes such as cell division, elongation and morphogenesis. Microtubule severing is an essential regulator of microtubules, and is exclusively executed by KATANIN 1 in Arabidopsis. In this study we comparatively studied the proteome-wide effects in two KATANIN 1 mutants. Thus, shot-gun proteomic analysis of roots and aerial parts of single nucleotide mutant fra2 and T-DNA insertion mutant ktn1-2 was carried out. We have detected 42 proteins differentially abundant in both fra2 and ktn1-2 KATANIN 1 dysfunction altered abundances of proteins involved in development, metabolism and stress responses...
July 13, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28662150/a-viral-metagenomic-approach-on-a-non-metagenomic-experiment-mining-next-generation-sequencing-datasets-from-pig-dna-identified-several-porcine-parvoviruses-for-a-retrospective-evaluation-of-viral-infections
#3
Samuele Bovo, Gianluca Mazzoni, Anisa Ribani, Valerio Joe Utzeri, Francesca Bertolini, Giuseppina Schiavo, Luca Fontanesi
Shot-gun next generation sequencing (NGS) on whole DNA extracted from specimens collected from mammals often produces reads that are not mapped (i.e. unmapped reads) on the host reference genome and that are usually discarded as by-products of the experiments. In this study, we mined Ion Torrent reads obtained by sequencing DNA isolated from archived blood samples collected from 100 performance tested Italian Large White pigs. Two reduced representation libraries were prepared from two DNA pools constructed each from 50 equimolar DNA samples...
2017: PloS One
https://www.readbyqxmd.com/read/28636236/assessment-of-silibinin-as-a-potential-antifungal-agent-and-investigation-of-its-mechanism-of-action
#4
Dae Gyu Yun, Dong Gun Lee
Silibinin, which is derived from Silybum marianum (milk thistle), has used as a traditional remedy for liver or biliary disorders and known to have superior antioxidant activity. In addition, silibinin was recently reported to have antifungal effect related to fungal apoptosis against Candida albicans and the interest in the therapeutic effect is increasing. In this study, we found another mode of antifungal action of silibinin and its antibiofilm activity on C. albicans. To investigate influence on fungal plasma membrane, propidium iodide and bis-(1, 3-dibutylbarbituric acid) trimethineoxonol [DiBAC4 (3)] assay were primarily carried out...
June 21, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28603241/-the-treatment-of-wounds-during-world-war-i
#5
Sergio Sabbatani, Sirio Fiorino
The First World War was a huge tragedy for mankind, but, paradoxically, it represented a source of significant progress in a broad series of human activities, including medicine, since it forced physicians to improve their knowledge in the treatment of a large number of wounded soldiers. The use of heavy artillery and machine guns, as well as chemical warfare, caused very serious and life-threatening lesions and wounds. The most frequent causes of death were not mainly related to gunshot wounds, but rather to fractures, tetanus and septic complications of infectious diseases...
June 1, 2017: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/28598691/development-of-68-ga-scn-dota-capsaicin-as-an-imaging-agent-targeting-apoptosis-and-cell-cycle-arrest-in-breast-cancer
#6
Jun Young Lee, Sang-Yeun Lee, Gun Gyun Kim, Min Goo Hur, Seung Dae Yang, Jeong-Hoon Park, Sang Wook Kim
(68)Ga-labeled capsaicin using a DOTA (1,4,7,10-tetraazocyclododecane-N,N',N″,N'″-tetraacetic acid) derivative [(68)Ga-SCN-Benzyl(Bn)-DOTA-capsaicin] was studied for the diagnosis of breast cancers, such as MCF-7 and SK-BR-3. The standard compound, (69)Ga-SCN-Bn-DOTA-capsaicin, was also prepared and characterized by spectroscopic analysis. The binding affinity of (68)Ga-SCN-Bn-DOTA-capsaicin was evaluated by using breast cancer cell lines (MCF-7, SK-BR-3) and colon cancer cell (CT-26); the biodistribution was carried out by using MCF-7-bearing nude mice, after which the positron emission tomography (PET) images were obtained at different time intervals (15-120 minutes)...
June 2017: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28467200/skin-microvascular-function-in-patients-with-type-1-diabetes-an-observational-study-from-the-onset-of-diabetes
#7
Pia Santesson, Per-Eric Lins, Majid Kalani, Ulf Adamson, Isak Lelic, Gunvor von Wendt, Bengt Fagrell, Gun Jörneskog
BACKGROUND: The development of disturbances in skin microcirculation in type 1 diabetes is not well characterised. We assessed skin microcirculation longitudinally from the onset of diabetes up to 29 years of duration to investigate when such disturbances start. MATERIAL AND METHODS: Seventeen adult patients with type 1 diabetes participated. Skin microvascular function in digit IV of the left hand was investigated by laser Doppler fluxmetry (LDF, arbitrary units [AU])...
May 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28426305/us-public-opinion-on-carrying-firearms-in-public-places
#8
Julia A Wolfson, Stephen P Teret, Deborah Azrael, Matthew Miller
OBJECTIVES: To estimate US public opinion, overall and by gun ownership status, about the public places where legal gun owners should be allowed to carry firearms. METHODS: We fielded an online survey among 3949 adults, including an oversample of gun owners and veterans, in April 2015. We used cross-tabulations with survey weights to generate nationally representative estimates. RESULTS: Fewer than 1 in 3 US adults supported gun carrying in any of the specified venues...
June 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28394817/comparative-bone-regeneration-potential-studies-of-collagen-heparin-and-polydopamine-coated-multichannelled-bcp-granules
#9
Gun Hee Lee, Preeti Makkar, Kallyanshis Paul, Byong Taek Lee
The present work is a comparative assessment of the bone regeneration potentiality of bone substitutes comprised of bioactive polymer coated biphasic calcium phosphate (BCP) granules. The bone substitutes were primarily composed of multichanneled BCP granules which were coated separately with biochemical polymer coatings, namely collagen, heparin or polydopamine, using chemical methods. The morphological features and chemical structure of the granules and surface coatings were characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) respectively...
April 6, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28368954/u-s-army-physical-demands-study-reliability-of-simulations-of-physically-demanding-tasks-performed-by-combat-arms-soldiers
#10
Stephen A Foulis, Jan E Redmond, Peter N Frykman, Maj Bradley J Warr, Edward J Zambraski, Marilyn A Sharp
Recently, the US Army has mandated that Soldiers must successfully complete the physically demanding tasks of their job in order to graduate from their Initial Military Training. Evaluating individual Soldiers in the field is difficult; however, simulations of these tasks may aid in the assessment of Soldiers' abilities. The purpose of this study was to determine the reliability of simulated physical Soldiering tasks relevant to Combat Arms Soldiers. Three cohorts of ∼50 Soldiers repeated a subset of eight simulated tasks four times over two weeks...
March 31, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28367592/whose-guns-are-stolen-the-epidemiology-of-gun-theft-victims
#11
David Hemenway, Deborah Azrael, Matthew Miller
BACKGROUND: Gun theft is an important source of guns used by criminals. Yet no empirical work has focused on the characteristics of gun owners that distinguish those who have had their guns stolen from those who have not. In this study, we examine the demographics and behavioral characteristics of gun owners who report having had a gun stolen. METHODS: Data come from a nationally representative probability-based online survey conducted in April 2015, with a linked follow-up survey in November 2015 that asked gun owners about any theft of their guns in the past 5 years...
December 2017: Injury Epidemiology
https://www.readbyqxmd.com/read/28260243/aggressive-and-violent-behavior-and-emotional-self-efficacy-is-there-a-relationship-for-adolescents
#12
Robert F Valois, Keith J Zullig, Asa A Revels
BACKGROUND: In this cross-sectional study we explored relationships between aggressive and violent behaviors and emotional self-efficacy (ESE) in a statewide sample of public high school adolescents in South Carolina (N = 3836). METHODS: The US Centers for Disease Control and Prevention Youth Risk Behavior Survey items on aggressive and violent behavior items and an adolescent ESE scale were used. Logistic regression analyses and multivariate models constructed separately, revealed significant race by sex findings...
April 2017: Journal of School Health
https://www.readbyqxmd.com/read/28260239/ten-year-secular-trends-in-youth-violence-results-from-the-philadelphia-youth-risk-behavior-survey-2003-2013
#13
Andrew C Pool, Freda Patterson, Ingrid Y Luna, Bernadette Hohl, Katherine W Bauer
BACKGROUND: Youth violence reduction is a public health priority, yet few studies have examined secular trends in violence among urban youth, who may be particularly vulnerable to numerous forms of violence. This study examines 10-year secular trends in the prevalence of violence-related behaviors among Philadelphia high school students. METHODS: Repeated cross-sectional data were analyzed from 5 waves of the Philadelphia Youth Risk Behavior Survey (YRBS) from 2003 to 2013...
April 2017: Journal of School Health
https://www.readbyqxmd.com/read/28207333/handgun-legislation-and-changes-in-statewide-overall-suicide-rates
#14
Michael D Anestis, Joye C Anestis, Sarah E Butterworth
OBJECTIVES: To examine the extent to which 4 laws regulating handgun ownership were associated with statewide suicide rate changes. METHODS: To test between-group differences in statewide suicide rate changes between 2013 and 2014 in all 50 states and the District of Columbia with and without specific laws, we ran analyses of covariance. RESULTS: We found significant differences in suicide rate changes from 2013 to 2014 in states with mandatory waiting periods and universal background checks relative to states without such laws...
April 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28193713/firearm-carrying-and-concurrent-substance-use-behaviours-in-a-community-based-sample-of-emerging-adults
#15
Robert N Buschmann, John D Prochaska, Jacques G Baillargeon, Jeff R Temple
INTRODUCTION: This paper examines associations between high-risk gun carrying and substance use in emerging adults (ages 18-22). The coexistence of these high-risk behaviours in a general population of emerging adults can have disastrous consequences. METHODS: Dating it Safe is an ongoing longitudinal (2010-2016) survey of emerging adults recruited from seven high schools in five south-east Texas-area school districts (current sample n=684). Multiple logistic regression modelling was used to examine the association between past-year use of legal and illegal substances and past-year firearm carrying for a reason other than sport or hunting...
February 13, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/28135726/the-relationships-among-exposure-to-violence-psychological-distress-and-gun-carrying-among-male-adolescents-found-guilty-of-serious-legal-offenses-a-longitudinal-cohort-study
#16
Joan A Reid, Tara N Richards, Thomas A Loughran, Edward P Mulvey
Background: Gun violence and psychological problems are often conflated in public discourse on gun safety. However, few studies have empirically assessed the effect of exposure to violence when exploring the association between gun carrying and psychological distress. Objective: To examine the potential effect of exposure to violence on the associations between gun carrying and psychological distress among vulnerable adolescents. Design: Longitudinal cohort study...
March 21, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28134622/mutations-in-tropomyosin-4-underlie-a-rare-form-of-human-macrothrombocytopenia
#17
Irina Pleines, Joanne Woods, Stephane Chappaz, Verity Kew, Nicola Foad, José Ballester-Beltrán, Katja Aurbach, Chiara Lincetto, Rachael M Lane, Galina Schevzov, Warren S Alexander, Douglas J Hilton, William J Astle, Kate Downes, Paquita Nurden, Sarah K Westbury, Andrew D Mumford, Samya G Obaji, Peter W Collins, Fabien Delerue, Lars M Ittner, Nicole S Bryce, Mira Holliday, Christine A Lucas, Edna C Hardeman, Willem H Ouwehand, Peter W Gunning, Ernest Turro, Marloes R Tijssen, Benjamin T Kile
Platelets are anuclear cells that are essential for blood clotting. They are produced by large polyploid precursor cells called megakaryocytes. Previous genome-wide association studies in nearly 70,000 individuals indicated that single nucleotide variants (SNVs) in the gene encoding the actin cytoskeletal regulator tropomyosin 4 (TPM4) exert an effect on the count and volume of platelets. Platelet number and volume are independent risk factors for heart attack and stroke. Here, we have identified 2 unrelated families in the BRIDGE Bleeding and Platelet Disorders (BPD) collection who carry a TPM4 variant that causes truncation of the TPM4 protein and segregates with macrothrombocytopenia, a disorder characterized by low platelet count...
March 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28073074/tribocorrosion-behavior-of-bio-functionalized-highly-porous-titanium
#18
F Toptan, A C Alves, A M P Pinto, P Ponthiaux
Titanium and its alloys are widely used in orthopedic and dental implants, however, some major clinical concerns such as poor wear resistance, lack of bioactivity, and bone resorption due to stress shielding are yet to be overcome. In order to improve these drawbacks, highly porous Ti samples having functionalized surfaces were developed by powder metallurgy with space holder technique followed by anodic treatment. Tribocorrosion tests were performed in 9g/L NaCl solution using a unidirectional pin-on-disc tribometer under 3N normal load, 1Hz frequency and 4mm track diameter...
January 4, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28069415/silymarin-exerts-antifungal-effects-via-membrane-targeted-mode-of-action-by-increasing-permeability-and-inducing-oxidative-stress
#19
Dae Gyu Yun, Dong Gun Lee
Silymarin, which is derived from the seeds of Silybum marianum, has been widely used to prevent and treat liver disorders. It is also consumed as a dietary supplement to improve liver function, as it does not exhibit any toxic effects in humans. Recently, silymarin has been reported to show antimicrobial effects against various pathogenic microorganisms, but the mode of action remains unknown. Thus, we investigated the antifungal activity of silymarin and aimed to determine the underlying mechanism. Initially, a propidium iodide assay was carried out; the results indicated that silymarin induced injury to the fungal plasma membrane...
January 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28064138/ultrasensitive-photoacoustic-sensor-based-on-quantum-cascade-laser-spectroscopy
#20
Deepak Kumar, Surya Gautam, Subodh Kumar, Saurabh Gupta, Hari B Srivastava, Surya N Thakur, Ramesh C Sharma
The paper focuses on development of ultra-sonic detection system based on laser photoacoustic spectroscopic technique and processing of signal for detection of very low quantity chemicals, explosive materials, and mixtures of these hazardous molecules. The detection system has been developed for the first time with specially designed one side open photo-acoustic cell having high quality factor. Explosive and Hazardous materials like RDX, DNT, PETN, Gun Powder, TATP (Tri acetone tri-peroxide) and their simulants like Acetone were detected in 7 to 9μm wavelength band...
November 23, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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