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dcda twins

Koenraad R Veys, Kathleen W D'Hauwers, Angelique J C M van Dongen, Mirian C Janssen, Martine T P Besouw, Ellen Goossens, Lambert P van den Heuvel, Alex A M M Wetzels, Elena N Levtchenko
Cystinosis is a rare autosomal recessive lysosomal storage disease characterized by multi-organ cystine accumulation, leading to renal failure and extra-renal organ dysfunction. Azoospermia of unknown origin is the main cause of infertility in all male cystinosis patients. Although spermatogenesis has shown to be intact at the testicular level in some patients, no male cystinosis patient has been reported yet to have successfully induced conception.We present the first successful conception ever reported, induced by a 27-year-old male renal transplant infantile nephropathic cystinosis patient through percutaneous epididymal sperm aspiration (PESA) followed by intracytoplasmatic sperm injection (ICSI)...
April 13, 2017: JIMD Reports
Eric Jauniaux, Yaakov Melcer, Ron Maymon
BACKGROUND: Twin pregnancies are at higher risks of velamentous cord insertion and vasa previa. In vitro fertilization is an additional risk factor of abnormal cord insertion and thus the incidence of vasa previa is likely to increase over the next decades. OBJECTIVE: We sought to evaluate the role of ultrasound imaging in optimizing the management of twins diagnosed with vasa previa antenatally. STUDY DESIGN: We searched our database for twin pregnancies diagnosed with vasa previa and managed antenatally using measurements of cervical length and performed a systematic review of articles that correlated prenatal diagnosis of vasa previa in twins and pregnancy outcome...
January 30, 2017: American Journal of Obstetrics and Gynecology
Oliver T Stirrup, Asma Khalil, Francesco D'Antonio, Baskaran Thilaganathan
INTRODUCTION: This study investigates patterns of intertwin size discordance in dichorionic diamniotic (DCDA) and monochorionic diamniotic (MCDA) twin pregnancies. MATERIAL AND METHODS: Ultrasound measurements of twin pregnancies, from 14 weeks to term, were collected by 9 hospitals over a 10-year period. This analysis considers the modelled and observed levels of discordance in abdominal circumference (AC) and estimated fetal weight (EFW) in relation to gestational age...
2017: Fetal Diagnosis and Therapy
Luming Sun, Gang Zou, Xing Wei, Yan Chen, Jun Zhang, Nanette Okun, Tao Duan
The chorionicity-based evaluation of the perinatal risk in twin pregnancies after assisted reproductive technology (ART) is lacking. A retrospective review was performed of all twin pregnancies monitored prenatally and delivered at our hospital between 2010 and 2014. Chorionicity was diagnosed by ultrasound examination at first trimester and confirmed by postnatal pathology. Pregnancy and perinatal outcomes were prospectively recorded. Adjusted odds ratios (aOR) with 95% confidence intervals (CI) were calculated in a logistic regression model...
2016: Scientific Reports
Seung Mi Lee, Joong Shin Park, Errol R Norwitz, Sitthysack Panyavatthanasinh, Sun Min Kim, JoonHo Lee, Chan-Wook Park, Byoung Jae Kim, Jong Kwan Jun
OBJECTIVE: To compare the concentrations of adipokines in amniotic fluid (AF) and cord blood collected from discordant dichorionic-diamniotic (DCDA) twin fetuses. STUDY DESIGN: The study population included DCDA twins discordant for fetal growth (birth weight difference >10%) who either underwent mid-trimester amniocentesis for routine clinical indication (Cohort 1) or whose amniotic fluid was collected at the time of delivery (Cohort 2). In both cohorts, cord blood was collected at delivery...
2016: PloS One
Hiroshi Kawamura, Keisuke Ishii, Naoto Yonetani, Aki Mabuchi, Shusaku Hayashi, Nobuaki Mitsuda
AIM: The aim of this study was to evaluate the long-term outcomes of very low birthweight twins by chorionicity and to identify the perinatal predictors for outcomes in the era of laser surgery for twin-twin transfusion syndrome. MATERIAL AND METHODS: This was a retrospective single-center cohort study of twin pregnancy infants <1500 g from 2003 through 2010. During the study period, laser surgery was performed on cases of twin-twin transfusion syndrome. The composite of adverse outcomes at 3 years of age was defined, including death, cerebral palsy, and developmental delay...
August 2015: Journal of Obstetrics and Gynaecology Research
Mariano Mascarenhas, Mohan S Kamath, K Muthukumar, Ann M Mangalaraj, Achamma Chandy, Tk Aleyamma
OBJECTIVES: The overwhelming numbers of twins following assisted reproductive technology (ART) are dichorionic twins, but monochorionic twins account for around 0.9% of post ART pregnancies. The data for post ART-monochorionic pregnancy outcomes are scarce due to the rarity of this condition. Hence, we evaluated the obstetric outcomes of monochorionic and dichorionic pregnancies conceived on ART. SETTINGS: University teaching hospital. STUDY DESIGN: A case-control study of monochorionic diamniotic (MCDA) and dichorionic diamniotic (DCDA) pregnancies conceived following ART treatment...
April 2014: Journal of Human Reproductive Sciences
Chinmayee Ratha, Anita Kaul
OBJECTIVE: The present study aims to analyze perinatal outcomes in twins given special care during pregnancy and labor and to compare fetal and neonatal outcomes in dichorionic twins with monochorionic twins. STUDY DESIGN: Eighty eight (88) twin pregnancies booked for care at a tertiary care Fetal Medicine centre were included in this study. The maternal demographic variables, course of pregnancy, fetal problems, and specialized fetal therapeutic and diagnostic interventions were noted...
August 2014: Journal of Obstetrics and Gynaecology of India
Minna E Geisler, Anne O'Mahony, Sarah Meaney, John J Waterstone, Keelin O'Donoghue
OBJECTIVE: Twin pregnancy is associated with increased obstetric and perinatal risk. There are conflicting reports on whether assisted conception (ART) further increases these risks. The aim of this study is to assess the obstetric and perinatal outcomes of twin pregnancies according to mode of conception. STUDY DESIGN: A retrospective study of all viable dichorionic-diamniotic (DCDA) twin pregnancies (n=539) delivered at Cork University Maternity Hospital, Ireland between 2009 and 2012, divided according to spontaneous conception (SC) and ART conception, specifically IVF or ICSI...
October 2014: European Journal of Obstetrics, Gynecology, and Reproductive Biology
O T Stirrup, A Khalil, F D'Antonio, B Thilaganathan
OBJECTIVE: To generate reference charts for expected fetal growth in dichorionic diamniotic (DCDA) and monochorionic diamniotic (MCDA) twin pregnancies and to compare these with those from singleton pregnancies. METHODS: This was a retrospective study of biometric measurements from serial ultrasound examinations of twin pregnancies in the second and third trimesters, from 14 weeks' gestation to term, collected by nine hospitals over a 10-year period. The measurements obtained in each fetus at each examination included head circumference (HC), biparietal diameter (BPD), abdominal circumference (AC) and femur length (FL)...
March 2015: Ultrasound in Obstetrics & Gynecology
Amir Aviram, Itay Weiser, Eran Ashwal, Jonathan Bar, Arnon Wiznitzer, Yariv Yogev
OBJECTIVE: We aimed to characterize risk factors for combined twin delivery and assess neonatal outcome. METHODS: This was a retrospective cohort study of all women admitted for trial of labor (TOL) with twin gestation, in a single, tertiary, university-affiliated medical center. Eligibility was limited to gestations with twin A delivered vaginally. RESULTS: During the study period, 44 263 women delivered in our center, of whom 1307 (2.9%) delivered twins...
March 2015: Journal of Maternal-fetal & Neonatal Medicine
Tanya Maric, Natasha Singh, Keith Duncan, Guy J Thorpe-Beeston, Makrina D Savvidou
OBJECTIVE: To investigate the relation between first-trimester fetal growth discrepancy, as assessed by crown-rump length (CRL) at 11+0 to 13+6 weeks of gestation, and subsequent development of preeclampsia (PE) in dichorionic diamniotic (DCDA) twin pregnancies. The association between inter-twin CRL and birth weight (BW) discrepancy was also investigated. METHODS: This was a retrospective, case-control study of DCDA twin pregnancies. Inter-twin CRL discrepancy was calculated as 100×(larger CRL-smaller CRL)/larger CRL...
November 2015: Journal of Perinatal Medicine
C Mulcahy, F M McAuliffe, F Breathnach, M Geary, S Daly, J Higgins, A Hunter, J Morrison, G Burke, S Higgins, P Dicker, R Mahony, E Tully, F Malone
OBJECTIVE: To construct monochorionic diamniotic (MCDA) and dichorionic diamniotic (DCDA) twin reference ranges for umbilical artery (UA) pulsatility index (PI), UA resistance index (RI), fetal middle cerebral artery (MCA) PI and peak systolic velocity (PSV) and cerebroplacental ratio (CPR) from 24 weeks' to 38 weeks' gestation and compare these with published normal values for singleton pregnancies. METHODS: This prospective multicenter cohort study included 1028 unselected twin pairs recruited over a 2-year period...
October 2014: Ultrasound in Obstetrics & Gynecology
H M Gardiner, H Matsui, M Roughton, S E Greenwald, A Diemert, M J O Taylor, K Hecher
OBJECTIVES: To compare cardiac function at 10 years of age in four groups of monochorionic diamniotic (MCDA) twin pairs: uncomplicated MCDA twins (n = 6) (Group 1); twins that had had twin-twin transfusion syndrome (TTTS) managed by amnioreduction (TTTS-amnio, n = 9) (Group 2) or laser photocoagulation (TTTS-laser, n = 10) (Group 3); and dichorionic diamniotic controls (DCDA, n = 6) (Group 4). METHODS: Echocardiograms optimizing apical four-chamber and short-axis left ventricular views were stored for offline speckle-tracking analysis, blinded to twin type...
June 2014: Ultrasound in Obstetrics & Gynecology
Francesca M Russo, Elisa Pozzi, Francesca Pelizzoni, Lyudmyla Todyrenchuk, Davide P Bernasconi, Sabrina Cozzolino, Patrizia Vergani
OBJECTIVES: To estimate the risk of stillbirth in dichorionic and monochorionic twins compared with singletons, and to evaluate the relevant causes of stillbirth in each group. STUDY DESIGN: A retrospective cohort analysis of all pregnancies ≥22 weeks of gestation was performed at a tertiary care center from January 1995 to June 2011. The overall fetal survival and the prospective risk of stillbirth were compared in monochorionic diamniotic (MCDA) twins, dichorionic diamniotic (DCDA) twins, and singletons...
September 2013: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Nihal Al Riyami, Asmaa Al-Rusheidi, Murtadha Al-Khabori
OBJECTIVE: The aim of this study is to compare the neonatal outcomes of monochorionic and dichorionic twin pregnancies. METHODS: A retrospective cohort study involving 51 twin pregnancies followed and delivered at Sultan Qaboos University Hospital was conducted between January 2006 and December 2011. RESULT: Thirty six (71%) pregnancies were dichorionic diamniotic (DCDA), 14 (27%) were monochorionic diamniotic (MCDA), and one (2%) was monochorionic monoamniotic (MCMA)...
May 2013: Oman Medical Journal
Rhona Mahony, Celia Mulcahy, Fionnuala McAuliffe, Colm O Herlihy, Stephen Carroll, Michael E Foley
OBJECTIVE: To examine the pattern and prospective risk of intrauterine fetal death (IUFD) in twin pregnancy by chorionicity. DESIGN: Retrospective cohort analysis. SETTING: Large national tertiary referral center. POPULATION: All consecutive twin deliveries (1997-2006) ≥24 weeks. METHODS: Retrospective review of all consecutive twin deliveries over 10 years to identify patterns of IUFD in twins and calculate gestation-specific prospective risks of IUFD...
November 2011: Acta Obstetricia et Gynecologica Scandinavica
Edward Mullins, Sailesh Kumar
Advanced maternal age may be associated with adverse maternal and perinatal outcomes in singleton pregnancies. It is unclear whether a similar association exists for dichorionic twins. This objective of this study was to ascertain whether advanced maternal age was associated with increased perinatal morbidity and mortality in a 15 year retrospective review of dichorionic diamniotic (DCDA) twins delivered at Queen Charlotte's and Chelsea Hospital, a tertiary referral center in London, UK, between 1994 and 2008...
January 2012: Acta Obstetricia et Gynecologica Scandinavica
S A Bora, A T Papageorghiou, C Bottomley, E Kirk, T Bourne
OBJECTIVES: To assess the agreement in the diagnosis of chorionicity and amnionicity between transvaginal ultrasound examination at 7-9 weeks' gestation and at the 11-14-week transabdominal scan. METHODS: This was a retrospective analysis of prospectively collected data of twin pregnancies over a 3-year period. Chorionicity and amnionicity were assessed in women with viable twin pregnancies who underwent a transvaginal ultrasound scan at between 7 and 9 weeks' gestation...
October 2008: Ultrasound in Obstetrics & Gynecology
A Sau, S Chalmers, A H Shennan, G Fox, D Maxwell
The outcomes of 60 sets of monochorionic diamniotic (MCDA) twins were compared with 218 sets of dichorionic diamniotic (DCDA) twins. The caesarean section rates for MCDA were similar to those for DCDA twins (56.6 versus 53.6%, P > 0.1). Although the number of babies with 5-minute Apgar score of <7 was significantly higher for vaginally delivered MCDA twins compared with that of DCDA twins (12 versus 3.5%, P < 0.001), the umbilical artery pH of <7.2 was similar (20 versus 13%, P > 0.05). Admission to neonatal intensive care unit (NICU) and neonatal mortality were also similar in both groups...
May 2006: BJOG: An International Journal of Obstetrics and Gynaecology
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