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https://www.readbyqxmd.com/read/29656490/cross-cultural-adaptation-reliability-and-validity-of-the-spanish-version-of-the-neonatal-skin-risk-assessment-scale
#1
Pablo García-Molina, Evelin Balaguer López, José Verdú, Andreu Nolasco, Francisco P García Fernández
AIM: To adapt the Neonatal Skin Risk Assessment Scale to the Spanish context and to test its validity and reliability. BACKGROUND: Currently, in Spain there are no validated scales to evaluate the risk of pressure ulcers in infants. METHOD: The research was performed in 10 neonatal units. Overall, we use an observational study design, but divided it in to three stages. In the first stage, the transcultural adaptation of the scale and its content validation was performed...
April 14, 2018: Journal of Nursing Management
https://www.readbyqxmd.com/read/29656427/exercise-training-abrogates-age-dependent-loss-of-hypothalamic-oxytocinergic-circuitry-and-maintains-high-parasympathetic-activity
#2
Carla R Santos, Adriana Ruggeri, Alexandre Ceroni, Lisete C Michelini
Neuroanatomical studies associating neuronal tract tracing and immunohistochemistry identified reciprocal (ascending noradrenergic/descending oxytocinergic, OTergic) connections between brainstem cardiovascular nuclei and the paraventricular hypothalamic nucleus (PVN). Previous functional studies indicated that exercise training (T) augmented the expression/activity of OTergic pathway and improve the autonomic control of the heart. Knowing that ageing is associated with autonomic dysfunction and sinoaortic denervation blocked T-induced beneficial effects, we hypothesized that T was able to reduce age-dependent impairment by improving the afferent signaling to PVN and augmenting OTergic modulation of cardiovascular control...
April 14, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29656082/ultra-high-performance-supercritical-fluid-chromatography-hyphenated-to-atmospheric-pressure-chemical-ionization-high-resolution-mass-spectrometry-for-the-characterization-of-fast-pyrolysis-bio-oils
#3
Julien Crepier, Agnès Le Masle, Nadège Charon, Florian Albrieux, Pascal Duchene, Sabine Heinisch
Extensive characterization of complex mixtures requires the combination of powerful analytical techniques. A Supercritical Fluid Chromatography (SFC) method was previously developed, for the specific case of fast pyrolysis bio oils, as an alternative to gas chromatography (GC and GC × GC) or liquid chromatography (LC and LC × LC), both separation methods being generally used prior to mass spectrometry (MS) for the characterization of such complex matrices. In this study we investigated the potential of SFC hyphenated to high resolution mass spectrometry (SFC-HRMS) for this characterization using Negative ion Atmospheric Pressure Chemical ionization ((-)APCI) for the ionization source...
April 7, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29655623/insulin-resistance-and-metabolic-syndrome-criteria-in-lean-normoglycemic-college-age-subjects
#4
Dana K Townsend, Katheryn McGregor, Esther Wu, Kathryn Cialkowski, Mark D Haub, Thomas J Barstow
AIMS: The goal of this study was to determine insulin sensitivity in a fasted state and during an oral glucose tolerance test (OGTT), in normoglycemic (NGT), lean (L) (n = 35) and, for comparison, overweight/obese (OW/O) (n = 9) college-aged subjects. MATERIALS AND METHODS: Insulin sensitivity for 44 NGT, normotensive subjects, age 18-26 yrs., was determined by homeostasis model assessment (HOMA-IR) and from Matsuda index (ISI Matsuda). RESULTS: Subjects were normoglycemic fasted (4...
March 31, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29652684/biphasic-cuirass-ventilation-during-anesthesia-for-tracheobronchial-stent-insertion-or-removal-by-a-rigid-bronchoscope-a-case-report
#5
Hideaki Mori, Atsuko Shono, Ritsuko Hirade, Tetsuro Nikai, Yoji Saito
Airway management and ventilation during a tracheobronchial stenting procedure are challenging given that mandatory positive pressure ventilation cannot be fully achieved while using a rigid bronchoscope due to leakage from the scope tip. Biphasic cuirass ventilation is a negative pressure ventilation method using an external cuirass fitted to the anterior chest, which could assist in spontaneous breathing and ventilation support. We report 3 successful anesthesia cases in which we could maintain adequate ventilation and oxygenation, supported by biphasic cuirass ventilation, in patients undergoing tracheobronchial stent placement or removal procedures using rigid bronchoscopy...
April 15, 2018: A&A practice
https://www.readbyqxmd.com/read/29652564/examining-the-relationship-between-nonalcoholic-fatty-liver-disease-and-the-metabolic-syndrome-in-nondiabetic-subjects
#6
Harry G Preuss, Gilbert R Kaats, Nate Mrvichin, Anand Swaroop, Debasis Bagchi, Dallas Clouatre, Jeffrey M Preuss
OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) is considered by some to be the hepatic manifestation of the metabolic syndrome (MS). However, others believe NAFLD is a distinct entity that actually initiates MS. Whichever is true, a definite linkage exists between both is generally accepted based upon the frequency of common occurrence and realization that insulin resistance (IR) is and realization that. The objective is to better understand the relationship between NAFLD and MS...
April 13, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29651393/wound-healing-potential-of-intermittent-negative-pressure-under-limited-access-dressing-in-burn-patients-biochemical-and-histopathological-study
#7
Honnegowda Thittamaranahalli Muguregowda, Pramod Kumar, Padmanabha Udupa Echalasara Govindarama
BACKGROUND: Malondialdehyde (MDA) is an oxidant that causes damage to membranes, DNA, proteins, and lipids at the cellular level. Antioxidants minimize the effects of oxidants and thus help in formation of healthy granulation tissues with higher level of hydroxyproline and total protein. This study compared the effect of limited access dressing (LAD) with conventional closed dressing biochemically and histopathologically. METHODS: Seventy-two 12-65 years old burn patients with mean wound size of 14 cm2 were divided to two groups of LAD (n=37), and conventional dressing groups (n=35)...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29651181/extracellular-synthesis-and-characterization-of-gold-nanoparticles-using-mycobacterium-sp-brs2a-ar2-isolated-from-the-aerial-roots-of-the-ghanaian-mangrove-plant-rhizophora-racemosa
#8
Mustafa Camas, Anil Sazak Camas, Kwaku Kyeremeh
Through the use of genomes that have undergone millions of years of evolution, marine Actinobacteria are known to have adapted to rapidly changing environmental pressures. The result is a huge chemical and biological diversity among marine Actinobacteria . It is gradually becoming a known fact that, marine Actinobacteria have the capability to produce nanoparticles which have reasonable sizes and structures with possible applications in biotechnology and pharmacology. Mycobacterium sp. BRS2A-AR2 was isolated from the aerial roots of the mangrove plant Rhizophora racemosa ...
June 2018: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/29650791/impairments-in-adipose-tissue-microcirculation-in-type-2-diabetes-mellitus-assessed-by-real-time-contrast-enhanced-ultrasound
#9
Donghua Hu, Devika Remash, Ryan D Russell, Timothy Greenaway, Stephen Rattigan, Kathryn A Squibb, Graeme Jones, Dino Premilovac, Stephen M Richards, Michelle A Keske
BACKGROUND: In obesity and type 2 diabetes mellitus (T2D), adipose tissue expansion (because of larger adipocytes) results in reduced microvascular density which is thought to lead to adipocyte hypoxia, inflammation, and reduced nutrient delivery to the adipocyte. Adipose tissue microvascular responses in humans with T2D have not been extensively characterized. Furthermore, it has not been determined whether impaired microvascular responses in human adipose tissue are most closely associated with adiposity, inflammation, or altered metabolism...
April 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29650262/triple-flap-technique-for-vulvar-reconstruction
#10
R Mercut, R Sinna, R Vaucher, P A Giroux, N Assaf, A Lari, S Dast
OBJECTIVE: Perineal defects are encountered ever more frequently, in the treatment of vulvar cancers or abdominoperineal resection. The surgical treatment of vulvar cancer leads to significant skin defect. The aim of the reconstruction is not to provide volume but rather to resurface perineum. We propose a new solution to cover the extensive skin defect remaining after excision. METHODS: We report 3 patients who underwent large excision for vulvar cancer, with lymph node dissection...
April 9, 2018: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29649758/association-between-nighttime-artificial-light-pollution-and-sea-turtle-nest-density-along-florida-coast-a-geospatial-study-using-viirs-remote-sensing-data
#11
Zhiyong Hu, Hongda Hu, Yuxia Huang
Artificial lighting at night has becoming a new type of pollution posing an important anthropogenic environmental pressure on organisms. The objective of this research was to examine the potential association between nighttime artificial light pollution and nest densities of the three main sea turtle species along Florida beaches, including green turtles, loggerheads, and leatherbacks. Sea turtle survey data was obtained from the "Florida Statewide Nesting Beach Survey program". We used the new generation of satellite sensor "Visible Infrared Imaging Radiometer Suite (VIIRS)" (version 1 D/N Band) nighttime annual average radiance composite image data...
April 9, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29649276/carbapenem-resistant-gram-negative-pathogens-in-a-german-university-medical-center-prevalence-clinical-implications-and-the-role-of-novel-%C3%AE-lactam-%C3%AE-lactamase-inhibitor-combinations
#12
Juri Katchanov, Lucia Asar, Eva-Maria Klupp, Anna Both, Camilla Rothe, Christina König, Holger Rohde, Stefan Kluge, Florian P Maurer
OBJECTIVES: To determine the spectrum of infections with multidrug-resistant Gram-negative bacteria (MDR-GNB) and the clinical impact of the newly available betalactam/betalactamase inhibitor combinations ceftolozane/tazobactam and ceftazidime/avibactam in a German academic tertiary care center. METHODS: Retrospective analysis. RESULTS: Between September 1, 2015 and August 31, 2016, 119 individual patients (0.22% of all hospital admissions) were colonized or infected with carbapenem-resistant MDR-GNB...
2018: PloS One
https://www.readbyqxmd.com/read/29649126/effects-of-rural-medical-insurance-on-chronically-ill-patients-choice-of-the-same-hospital-again-in-rural-northern-china
#13
Ke Jiang, Daming You, Zhendong Li, Wei Wei, Mitchell Mainstone
The emergence of rural health insurance plays a crucial role in alleviating the pressure on rural medical expenditure. Under the current medical system in northern China, rural medical insurance may reduce the free referral of patients with chronic diseases among hospitals. This study was carried out based on the results of an investigation of rural chronically-ill patients in eight county hospitals in northern China, as well as through the comparison and analysis of patients with chronic diseases, considering whether they were with or without rural health insurance...
April 12, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29649067/outpatient-negative-pressure-wound-therapy-following-surgical-debridement-results-and-complications
#14
Eran Tamir, Aharon S Finestone, Itay Wiser, Yoram Anekstein, Gabriel Agar
OBJECTIVE: To present results and complications in a case series of outpatients with diabetic and neuropathic foot ulcers with exposed bone following surgical debridement treated with negative-pressure wound therapy (NPWT). METHODS: Retrospective data were obtained from digital medical records from the Maccabi Health Services High Risk Foot Clinic in Tel Aviv, Israel, between 2009 and 2014. Medical records examined were those of clinic outpatients with exposed bone following partial foot amputation or selective bone debridement (University of Texas grade III-A) treated with NPWT...
April 11, 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29644919/high-neutrophil-lymphocyte-ratio-in-schizophrenia-independent-of-infectious-and-metabolic-parameters
#15
Rabia Nazik Yüksel, Irem Ekmekci Ertek, Asiye Uğraş Dikmen, Erol Göka
BACKGROUND: Immunological and inflammatory mechanisms play an important role in schizophrenia. In the literature, there are studies investigating neutrophil-lymphocyte ratio (NLR) association with schizophrenia. AIMS: The purpose of this study was to compare NLR values between patients with schizophrenia and healthy controls. In addition, the study aimed to investigate the relationship between NLR and disease severity and some metabolic/inflammatory parameters. METHODS: Fifty-two patients diagnosed with schzophrenia and 53 healthy controls were included in the study...
April 12, 2018: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29644884/prospective-analysis-of-surgical-bone-margins-after-partial-foot-amputation-in-diabetic-patients-admitted-with-moderate-to-severe-foot-infections
#16
Brian M Schmidt, Jonathan B McHugh, Rajiv M Patel, James S Wrobel
BACKGROUND: Osteomyelitis is common in diabetic foot infections and medical management can lead to poor outcomes. Surgical management involves sending histopathologic and microbiologic specimens which guides future intervention. We examined the effect of obtainment of surgical margins in patients undergoing forefoot amputations to identify patient characteristics associated with outcomes. Secondary aims included evaluating interobserver reliability of histopathologic data at both the distal-to and proximal-to surgical bone margin...
April 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29644297/negative-pressure-in-treatment-of-persistent-post-traumatic-subcutaneous-emphysema-with-respiratory-failure-case-report-and-literature-review
#17
Jakov Mihanović, Ivan Bačić, Nina Sulen
Subcutaneous emphysema may aggravate traumatic pneumothorax treatment, especially when mechanical ventilation is required. Expectative management usually suffices, but when respiratory function is impaired surgical treatment might be indicated. Historically relevant methods are blowhole incisions and placement of various drains, often with related wound complications. Since the first report of negative pressure wound therapy for the treatment of severe subcutaneous emphysema in 2009, only few publications on use of commercially available sets were published...
February 2018: Trauma Case Reports
https://www.readbyqxmd.com/read/29644234/modelling-coronary-flow-after-the-norwood-operation-influence-of-a-suggested-novel-technique-for-coronary-transfer
#18
Mohammed K Al-Jughiman, Maryam A Al-Omair
Background: The dynamic behavior of the aortic sinuses has an important function in the specific characteristics of coronary blood flow. Several publications have confirmed suboptimal myocardial perfusion after the Norwood procedure. Our study was undertaken to confirm four hypotheses. First, we hypothesized that there is more resistance to coronary flow due to coronary attachments to hypoplastic aortic root and sinuses. Also, as the amalgamation of the ascending aorta with the pulmonary artery occurs above the aortic root, the coronary blood flow is not fully in antegrade pattern...
March 14, 2018: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/29644085/protein-molecular-modeling-shows-residue-t599-is-critical-to-wild-type-function-of-polg-and-description-of-a-novel-variant-associated-with-the-sando-phenotype
#19
John E Richter, Hector G Robles, Elizabeth Mauricio, Ahmed Mohammad, Paldeep S Atwal, Thomas R Caulfield
Sensory ataxic neuropathy with dysarthria and ophthalmoparesis (SANDO) is a rare phenotype resulting from pathogenic variants of mitochondrial DNA polymerase gamma ( POLG ). We modeled a novel POLG variant, T599P, that causes the SANDO phenotype and another variant at the same residue, p.T599E, to observe their effect on protein function and confirm the pathogenicity of T599P. Through neoteric molecular modeling techniques, we show that changes at the T599 residue position introduce extra rigidity into the surrounding helix-loop-helix, which places steric pressure on nearby nucleotides...
2018: Human Genome Variation
https://www.readbyqxmd.com/read/29643817/overexpression-of-%C3%A3-arrestin1-in-the-rostral-ventrolateral-medulla-downregulates-angiotensin-receptor-and-lowers-blood-pressure-in-hypertension
#20
Jia-Cen Sun, Bing Liu, Ru-Wen Zhang, Pei-Lei Jiao, Xing Tan, Yang-Kai Wang, Wei-Zhong Wang
Background: Hypertension is characterized by sympathetic overactivity, which is associated with an enhancement in angiotensin receptor type I (AT1R) in the rostral ventrolateral medulla (RVLM). β-arrestin1, a canonical scaffold protein, has been suggested to show a negative effect on G protein-coupled receptors via its internalization and desensitization and/or the biased signaling pathway. The major objectives of the present study were to observe the effect of β-arrestin1 overexpression in the RVLM on cardiovascular regulation in spontaneously hypertensive rats (SHR), and further determine the effect of β-arrestin1 on AT1R expression in the RVLM...
2018: Frontiers in Physiology
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