Read by QxMD icon Read


Vatsala Dwivedi, Kirti Kumari, Sanjay Kumar Gupta, Rekha Kumari, Charu Tripathi, Pushp Lata, Neha Niharika, Amit Kumar Singh, Roshan Kumar, Aeshna Nigam, Nidhi Garg, Rup Lal
A Gram negative, yellow pigmented, rod shaped bacterium designated as RL(T) was isolated from a hot water spring (90-98 °C) located at Manikaran in Northern India. The isolate grows at 60-80 °C (optimum, 70 °C) and at pH 7.0-9.0 (optimum pH 7.2). Phylogenetic analysis of 16S rRNA gene sequences and levels of DNA-DNA relatedness together indicate that the new isolate represents a novel species of the genus Thermus with closest affinity to Thermus thermophilus HB8(T) (99.5 %) followed by Thermus arciformis (96...
December 2015: Indian Journal of Microbiology
Erik von Seth, Urban Arnelo, Lars Enochsson, Annika Bergquist
BACKGROUND & AIMS: Patients with primary sclerosing cholangitis (PSC) have an increased risk for adverse events following endoscopic retrograde cholangiopancreatography (ERCP), mainly caused by bacterial cholangitis. The risk of pancreatitis is less examined. Therefore, our aim was to study adverse events following ERCP and to evaluate if PSC is a risk factor for pancreatitis. METHODS: Data were collected through a Swedish nationwide quality registry comprising fifty-one Swedish ERCP centres...
January 2015: Liver International: Official Journal of the International Association for the Study of the Liver
Tomoaki Murakami, Atsuhito Takeda, Hirokuni Yamazawa, Shigeru Tateno, Yasutaka Kawasoe, Koichiro Niwa
Despite the apparently successful surgical repair of aortic coarctation, subsequent cardiovascular complications have sometimes been encountered. Aortic pressure wave reflection is one of the risk factors for developing cardiovascular diseases, and an enhancement of the pressure wave reflection has been reported in patients after aortic arch repair. To clarify this issue, the increase in pressure wave reflection was evaluated in patients <15 years old who underwent aortic arch repair. This study enrolled 35 patients after aortic arch repair in early infancy...
July 2013: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Sandra Morales, Valery Naranjo, Us Angulo, Mariano Alcaniz
The algorithm proposed in this paper allows to automatically segment the optic disc from a fundus image. The goal is to facilitate the early detection of certain pathologies and to fully automate the process so as to avoid specialist intervention. The method proposed for the extraction of the optic disc contour is mainly based on mathematical morphology along with principal component analysis (PCA). It makes use of different operations such as generalized distance function (GDF), a variant of the watershed transformation, the stochastic watershed, and geodesic transformations...
April 2013: IEEE Transactions on Medical Imaging
Susie E Huntington, Loveleen K Bansi, Claire Thorne, Jane Anderson, Marie-Louise Newell, Graham P Taylor, Deenan Pillay, Teresa Hill, Pat A Tookey, Caroline A Sabin
BACKGROUND: The UK Collaborative HIV Cohort (UK CHIC) is an observational study that collates data on HIV-positive adults accessing HIV clinical care at (currently) 13 large clinics in the UK but does not collect pregnancy specific data. The National Study of HIV in Pregnancy and Childhood (NSHPC) collates data on HIV-positive women receiving antenatal care from every maternity unit in the UK and Ireland. Both studies collate pseudonymised data and neither dataset contains unique patient identifiers...
2012: BMC Medical Research Methodology
S M McGlone, R R Bailey, S M Zimmer, M J Popovich, Y Tian, P Ufberg, R R Muder, B Y Lee
Although Clostridium difficile (C. difficile) is the leading cause of infectious diarrhoea in hospitalized patients, the economic burden of this major nosocomial pathogen for hospitals, third-party payers and society remains unclear. We developed an economic computer simulation model to determine the costs attributable to healthcare-acquired C. difficile infection (CDI) from the hospital, third-party payer and societal perspectives. Sensitivity analyses explored the effects of varying the cost of hospitalization, C...
March 2012: Clinical Microbiology and Infection
Meltem Tor, Mesut Oztürk, Remzi Altın, Arif Hikmet Cımrın
In Turkey, bituminous coal mining is performed only in Zonguldak coal basin since 1940. Pneumoconiosis surveillance programs and dust control measures are in effect, but published pneumoconiosis data from this area is lacking. In this study, we aimed to evaluate the change in prevalence and case detection between 1985 and 2004 and assess the correlation between the dust concentration in workplaces and the prevalence of pneumoconiosis. Data on respirable dust concentrations and number of workers diagnosed as pneumoconiosis between 1985 and 2004 were obtained from Turkish Coal Enterprises authorities...
2010: Tüberküloz Ve Toraks
Carl van Walraven, Robert G Hart, Stuart Connolly, Peter C Austin, Jonathan Mant, F D Richard Hobbs, Peter J Koudstaal, Palle Petersen, Francisco Perez-Gomez, J Andre Knottnerus, Beppie Boode, Michael D Ezekowitz, Daniel E Singer
BACKGROUND AND PURPOSE: Stroke risk increases with age in patients who have nonvalvular atrial fibrillation. It is uncertain whether the efficacy of stroke prevention therapies in atrial fibrillation changes as patients age. The objective of this study was to determine the effect of age on the relative efficacy of oral anticoagulants (OAC) and antiplatelet (AP) therapy (including acetylsalicylic acid and triflusal) on ischemic stroke, serious bleeding, and vascular events in patients with atrial fibrillation...
April 2009: Stroke; a Journal of Cerebral Circulation
Brice Müller, Guillaume Braud, Xavier Tillou, Georges Karam, Olivier Bouchot, Jérôme Rigaud
OBJECTIVE: To analyse the medium-term oncological results of total nephroureterectomy for upper tract urothelial tumour according to the surgical approach: laparoscopy or open surgery. MATERIAL: Retrospective study including 38 consecutive patients undergoing total nephroureterectomy for upper tract urothelial tumour in our department. Patients were classified into 2 groups according to the surgical approach: Group 1 (19 patients) laparoscopic release of the kidney +/- distal ureter and Group 2 (19 patients) open surgery of the kidney and ureter...
November 2007: Progrès en Urologie
Sheng-Qing Xia, Svilen Bobev
A new transition-metal-containing Zintl phase, Ba11Cd8Bi14, has been synthesized by a Cd-flux reaction, and its structure has been determined by a single-crystal X-ray diffraction. Ba11Cd8Bi14 crystallizes in the monoclinic space group C2/m (No. 12, Z = 2) with a = 28.193(8) A, b = 4.8932(14) A, c = 16.823(5) A, and beta = 90.836(4) degrees , taken at -150 degrees C (R1 = 0.0407, wR2 = 0.1016). The structure can be described as being built of complex polyanionic [Cd8Bi14]22- layers running along the b axis, which are separated by the Ba2+ cations...
September 4, 2006: Inorganic Chemistry
X Wang, D Pei
The shedding of membrane-associated proteins has been recognized as a regulatory mechanism to either up-regulate or down-regulate cellular functions by releasing membrane-bound growth factors or removing ectodomains of adhesion molecules and receptors. We have reported previously that the ectoenzyme of membrane type matrix metalloproteinase 5 (MT5-MMP) is shed into extracellular milieu (Pei, D. (1999) J. Biol. Chem. 274, 8925-8932). Here we present evidence that MT5-MMP is shed by a furin-type convertase activity in the trans-Golgi network...
September 21, 2001: Journal of Biological Chemistry
X Wang, J Yi, J Lei, D Pei
We have recently identified the fifth member of the membrane-type matrix metalloproteinase subfamily, MT5-MMP/MMP24, which is expressed in a brain specific manner (Duanqing Pei (1999) J. Biol. Chem. 274, 8925-8932). To further characterize its enzymic properties, an expression construct was engineered to produce MT5-MMP as a soluble and active form by truncating its transmembrane domain. Stable expression cell lines were subsequently established from MDCK cells transfected with this construct. Unfortunately, purification of MT5-MMP from the culture media in large quantity proves to be difficult initially due to its rapid turnover via a mechanism which can be inhibited by a broad spectrum metalloproteinase inhibitor, BB94...
December 3, 1999: FEBS Letters
R Melki, S Fievez, M F Carlier
ATP and GTP are hydrolyzed during self-assembly of actin and tubulin, respectively. It is known that nucleotide is hydrolyzed on the polymer in two consecutive steps, chemical cleavage of the gamma-phosphate followed by the slower release of Pi. This last step has been shown to play a crucial role in the dynamics of actin filaments and microtubules. Thus far, evidence for a transient GDP-Pi state in microtubule assembly has been obtained using a glass fiber filter assay that had a poor time resolution [Melki, R...
September 17, 1996: Biochemistry
F S Mi
The synergetic radiosensitizing effect of isomers S-8932 and S-8933 on HeLa-S3 cell-line was investigated in vitro using cell colony forming assay. The results suggested that the combined use of the two isomers showed a lower cytotoxicity than their single use. The ID50 was 55.3 mM. Their synergetic radiosensitizing effect on HeLa-S3 cells under hypoxic condition was higher than either one used alone. The SER of the combined one at 4mM was 1.98 (D0 ratio) and 1.79 (D9 ratio) indicating a sensitizing effect at both low and high radiation doses...
March 1993: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
C A MacArthur, D B Shankar, G M Shackleford
We have used mouse mammary tumor virus (MMTV) infection of Wnt-1 transgenic mice to accelerate mammary tumorigenesis and to molecularly tag insertionally activated proto-oncogenes that cooperate oncogenically with Wnt-1 (G. M. Shackleford, C. A. MacArthur, H. C. Kwan, and H. E. Varmus, Proc. Natl. Acad. Sci. USA 90:740-744, 1993). Here we report the identification and characterization of a 31-kb genomic locus that contains clonal MMTV integrations in 8 of 80 mammary tumors from MMTV-infected Wnt-1 transgenic mice...
April 1995: Journal of Virology
D P Mascotti, T M Lohman
We have examined the thermodynamics of binding of a series of oligolysines (net charge z = +2 to +10) containing one, two, or three tryptophans to several single-stranded (ss) homo-polynucleotides [poly(A), poly(C), poly(I), poly(dU), poly(dT)] and duplex (ds) DNA in order to investigate the effects of peptide charge, tryptophan content, and polynucleotide base and sugar type. Equilibrium association constants, Kobs, were measured as a function of monovalent salt concentration (KCH3CO2) and temperature by monitoring the quenching of the peptide tryptophan fluorescence upon interaction with the polynucleotides, from which the dependence of delta G(o)obs, delta H(o)obs, and delta S(o)obs on [KCH3CO2] was obtained...
October 12, 1993: Biochemistry
R C Hahn, D B Petitti
Using data from the Walnut Creek Contraceptive Drug Study (a prospective study begun in 1969 and continuing to the present), Minnesota Multiphasic Personality Inventory-(MMPI) measured scores for depression of 8932 women were studied in relation to the incidence of breast cancer. No statistically significant association between MMPI scores for depression and the subsequent development of breast cancer was found. There was neither an association of risk of breast cancer with repression/sensitization as measured on the MMPI nor with scores on the MMPI lie scale...
February 15, 1988: Cancer
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"