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Surgical Managment of Germ Cell Tumors of Ovary

Atif Ali Hashmi, Samreen Naz, Muhammad Muzzammil Edhi, Naveen Faridi, Syed Danish Hussain, Shazia Mumtaz, Mehmood Khan
BACKGROUND: Ovarian neoplasms are a heterogeneous group of tumors including surface epithelial, germ cell and sex cord stromal tumors with a subset having low malignant potential (borderline tumors). While the surgical management plan differs in different categories of tumors, preoperative diagnosis is seldom available. In these circumstances, the role of frozen section becomes invaluable. In the current study, we aimed to evaluate the accuracy of the frozen section of ovarian tumors in our setup...
2016: World Journal of Surgical Oncology
Abrar Ahmed, Lan Peng, Deepak Agrawal
Cystic teratomas are a rare type of germ cell neoplasms derived from one or more germ layers. They can be classified as mature and immature teratomas based on the maturity of neuroectodermal elements within the tumor. Mature teratomas are benign, well-differentiated lesions, which may be solid or cystic. Mature cystic teratomas (MCTs) are also called dermoid cysts - a term likely coming from early surgical literature when the resected cysts resembled skin. Immature teratomas are malignant, undifferentiated tumors and generally solid...
July 2015: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
E Ismail, Y Kornovski
The germ-cells tumors are the most common ovarian malignancy in young women between 15-25 years. Often advanced disease is present at the time of diagnosis. The management and treatment approaches of disgerminoma and immature teratoma, as most common germ-cells tumors (GST), are presented. Two clinical cases of advanced stages of GST with complete remision after conservative surgical treatment and chemotherapy have been reviewed.
2015: Akusherstvo i Ginekologii︠a︡
Giovanni Cecchetto
UNLABELLED: PEDIATRIC GERM CELL TUMORS (GCT) ARE RARE TUMORS: 80% are benign, 20% malignant (2-3% of all malignant pediatric tumors). The gonadal sites (ovary and testis) account for 40% of cases. OVARIAN GCTS: Represent 30% of GCTs and 70% of neoplastic ovarian masses, being the most common ovarian neoplasms in children and teenagers. Benign and immature forms (teratomas) constitute about 80% of all ovarian GCTs, malignant forms represent 20% increasing during adolescence...
October 2014: Journal of Indian Association of Pediatric Surgeons
J Bouquet de Jolinière, N Ben Ali, A Fadhlaoui, J B Dubuisson, L Guillou, A Sutter, D Betticher, H M Hoogewoud, A Feki
OBJECTIVE: In this article, we present two case reports. The first case was a malignant germ cell tumor of the right ovary in a 23-year old woman and the second case was a bilateral undifferentiated granulosa cell tumor in a 71-year old woman. The aim of these reports is to illustrate the interest of the immunohistochemical analysis to define the correct diagnosis, to better classify these ovarian tumors and improve their management. METHODS: In this study, we report two cases...
2014: Frontiers in Oncology
Magdy M Saber, Ahmed A Zeeneldin, Mosaad M El Gammal, Salem E Salem, Amira D Darweesh, Alshaymaa A Abdelaziz, Manar Monir
INTRODUCTION: Female germ cell tumors (GCTS) are rare tumors that carry a good prognosis. AIM: To report the experience of the Egyptian National Cancer Institute (ENCI) in managing female GCTs. METHODS: This retrospective study included 19 females with ovarian GCTs presenting to the ENCI between 2006 and 2010. RESULTS: The median age was 23years. Ovaries were the primary site in all patients. Dysgerminoma and teratoma were the predominant pathologies followed by mixed GCT in females...
June 2014: Journal of the Egyptian National Cancer Institute
Nexhmi Hyseni, Sadik Llullaku, Hysni Jashari, Kaltrina Zahiti, Fjolla Hyseni, Fisnik Kurshumliu, Lumturije Luci, Fehim Muqolli, Antigona Hasani
Introduction. Ovarian dysgerminoma is a rare malignant ovarian germ cell tumor with its peak incidence in young women. Abdominal pain, abdominal distention, and the presence of a palpable mass are common symptoms at presentation. Depending on the FIGO stage at presentation the prognosis of dysgerminomas after surgical treatment, adjuvant chemotherapy, and radiotherapy is promising. Case Presentation. A 7-year-old girl was presented at our clinic with abdominal pain in all abdominal quadrants. Later the pain localized in the region of her right ovary...
2014: Case Reports in Oncological Medicine
Rasha Elashry, Reda Hemida, Hosam Goda, El-Said Abdel-Hady
BACKGROUND: Ovarian tumors in the pediatric age group are not infrequent. Germ-cell tumors are the commonest ovarian neoplasm in the first two decades of life. Sex cord-stromal tumors are the most common ovarian tumors to cause precocious puberty in girls. PATIENTS AND METHODS: This retrospective study included all managed cases of malignant germ-cell and sex cord-stromal tumors in the pediatric age (less than 18 years). The medical records of the admitted cases from first of January, 2008 to 31 December, 2012 were reviewed and the following information was collected: patient age, clinical presentation, surgical stage, tumor histology, therapy, clinical course, and outcome...
2013: Journal of Experimental Therapeutics & Oncology
Maria H Lin, Masoud Shamszadeh, Pisit Pitukcheewanont
Complete androgen insensitivity syndrome (AIS) is an X-linked disorder of sex development. Surgical management entails timely gonadectomy given the risk of malignant transformation. Our patient presented at age 15 years with primary amenorrhea. Initial laboratory testing showed elevated testosterone, luteinizing hormone, anti-Müllerian hormone levels, and 46,XY karyotype. Imaging studies showed no uterus, ovaries, and identified two candidate gonads. She underwent bilateral gonadectomy. Pathology reports revealed Sertoli cell and intratubular germ cell tumors located in separate gonads...
2012: Journal of Pediatric Endocrinology & Metabolism: JPEM
D Bolla, N Deseö, A Sturm, A Schöning, C Leimgruber
Mature cystic teratomas (MCTs) of the ovary represent 44% of ovarian neoplasmas. The surgical approach is important in young women especially for the cosmetic results. Nowadays most of the ovarian surgeries can be performed laparoscopically. An alternative between laparoscopy and laparotomy is the minilaparotomy (ML) which can be an interesting option, thanks to the small incision. We report a 39-year-old woman who was referred to our hospital with acute abdominal pain. In her past history the patient had an uncomplicated delivery...
2012: Case Reports in Obstetrics and Gynecology
Erica W M Janszen, Helena C van Doorn, Patricia C Ewing, Ronald R de Krijger, Johannes H W de Wilt, Boen L R Kam, Wouter W de Herder
BACKGROUND: Malignant struma ovarii is a rare malignant germ cell tumor of the ovary. Due to the rarity of this disease, treatment has not been uniform throughout the published literature. CASES: We present three cases of malignant struma ovarii. Following primary surgery, all were subsequently treated with thyroidectomy and (131)I ablation therapy, two patients as first line management, one following the occurrence of metastatic disease. CONCLUSION: Histological diagnosis of malignant struma ovarii is similar to that of well differentiated thyroid carcinoma (WDTC)...
2008: Clinical Medicine. Oncology
Chao Yang, Shan Wang, Chang-Chun Li, Jun Zhang, Xiang-Ru Kong, Jun Ouyang
PURPOSE: Ovarian germ cell tumors are rare in childhood. The goal of the study is to provide information that may help guide the evaluation and surgical management of future children with ovarian tumors. METHODS: A retrospective review of patients with ovarian germ cell tumors between January 1990 and January 2010 was performed. RESULTS: 137 patients were included with a median age of 9.5 years. Teratomas were found most frequently (mature: 78, immature: 6), followed by yolk sac tumors (n = 51), dysgerminoma (n = 1) and embryonal carcinoma (n = 1)...
2011: European Journal of Gynaecological Oncology
El-Said Abdel-Hady, Reda Abdel-Hady Hemida, Anas Gamal, Maged El-Shamey
OBJECTIVES: To study the outcome of fertility conserving surgery for ovarian tumors in children and young adults (≤ 20 years) over 6 years (2003-2009). METHODS: This prospective study included 183 patients diagnosed with ovarian cysts or tumors requiring surgical excision. Ovarian cystectomy/ovariectomy was carried out followed by frozen section histopathology. Malignant cases were subjected to staging laparotomy and fertility sparing surgery. RESULTS: The median age at diagnosis was 17 years (range 7-20 years)...
February 2012: Archives of Gynecology and Obstetrics
Satomi Kikawa, Yukiharu Todo, Shinichiro Minobe, Katsushige Yamashiro, Hidenori Kato, Noriaki Sakuragi
Growing teratoma syndrome (GTS) is defined as enlarging masses during or after chemotherapy for germ cell tumors, and containing only mature teratoma components. A surgical resection is important to confirm a diagnosis and thereby result in the resection of the most appropriate therapeutic management. GTS is a rare event in association with ovarian germ cell tumors. This report presents a case of a 36-year-old female treated surgically for GTS found during the follow-up after chemotherapy and the primary surgical resection of a malignant immature teratoma...
July 2011: Journal of Obstetrics and Gynaecology Research
Ramez N Eskander, Leslie M Randall, Michael L Berman, Krishnansu S Tewari, Philip J Disaia, Robert E Bristow
A proportion of reproductive age women are affected by gynecologic malignancies. This patient population is faced with difficult decisions, related to their cancer care and treatment, as well as future childbearing potential. Therefore, it is important for gynecologists to be familiar with fertility sparing management options in patients with cervical, ovarian, and endometrial cancer. In addition to understanding the surgical approaches available, providers should be able to counsel patients regarding their eligibility for and the indications and limitations of fertility sparing therapy for gynecologic cancer, allowing for appropriate referrals...
August 2011: American Journal of Obstetrics and Gynecology
Nabila Rasool, Peter G Rose
Gynecologic malignancies often affect young women who are at the peak of their reproductive potential. The treatment for gynecologic malignancies often consists of removal of the ovaries or uterus, affecting the future fertility of these patients. Advances in surgical management have allowed patients to undergo more conservative treatment with preservation of their fertility. This review summarizes fertility-sparing surgical procedures for patients with gynecologic malignancies evaluating the role of radical trachelectomy and ovarian transposition in cervical cancer, hormonal therapy and hysteroscopic resection in endometrial cancer, and conservative surgery in ovarian cancer...
December 2010: Clinical Obstetrics and Gynecology
Natalie Catharine Moniaga, Leslie M Randall
BACKGROUND: Malignant germ cell tumors of the ovary are relatively rare, making up less than 10% of all ovarian cancers. However, although they represent only a small fraction of ovarian cancers overall, they frequently affect adolescent women of reproductive age, making fertility sparing treatment of paramount importance. Malignant germ cell tumors are subdivided into dysgerminoma and nondygerminomatous tumors. The most common types of nondysgerminomatous tumors are yolk sac and immature teratoma...
February 2011: Journal of Pediatric and Adolescent Gynecology
Anju Rani Sengar, Jagdeesh Narhar Kulkarni
A 26-year-old girl was referred to us in December 2008 with progressive pelvic mass while on chemotherapy. In May 2008, she presented with large adnexal mass and high alpha-fetoprotein (AFP, 265.7 ng/mL; normal range, 0 to 10). She underwent laparoscopic right salpingo-oophorectomy with staging. Since histology was immature teratoma grade I, FIGO stage 1 she was kept on surveillance. In September 2008, she developed recurrent pelvic mass with AFP levels of 2,400 ng/mL. Three courses of chemotherapy (bleomycin-etoposide-cisplatin) were given...
June 2010: Journal of Gynecologic Oncology
I Ray-Coquard, P Pautier, E Pujade-Lauraine, P Méeus, P Morice, I Treilleux, P Duvillard, J Alexandre, C Lhommé, F Selle, Jp Guastalla
Majorities of the rare ovarian cancers were represented by germ cell tumours and sex cords ovarian tumours with borderline tumours, clear cell carcinoma and mucinous carcinoma and are extremely rare malignant diseases of the ovaries. Tumors of the stromal (Leydig cells) and/or sex cords (Sertoli cells) represent approximately 7% of ovarian cancers and develop from the conjunctive tissue (respectively, interstitial and nurse cells) of the ovaries. All together, they represented less than 5% of the adult malignant and non malignant ovarian tumours...
January 2010: Bulletin du Cancer
Jenifer D McCarthy, Kimberly M Erickson, Yolanda R Smith, Elisabeth H Quint
BACKGROUND: Ovarian tumors are the most common gynecologic malignancy occurring in childhood, with germ cell tumors being most frequent. This contrasts with adults where epithelial tumors account for most ovarian neoplasms. Tumor markers are an integral part of the work-up and may guide management. CASE: A 6-year-old girl with a persistent adnexal mass was found to have a highly elevated CA-125. Other tumor markers were normal. Laparoscopy revealed an enlarged, adherent ovary...
February 2010: Journal of Pediatric and Adolescent Gynecology
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