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Breast Conservative Surgery

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https://www.readbyqxmd.com/read/28324266/quality-of-life-in-patients-with-recurrent-breast-cancer-after-second-breast-conserving-therapy-in-comparison-with-mastectomy-the-german-experience
#1
Svenja Jendrian, Katharina Steffens, Barbara Schmalfeldt, Elena Laakmann, Corinna Bergelt, Isabell Witzel
BACKGROUND: Although some studies suggest that breast-conserving therapy (BCT) shows better psychosocial outcomes than mastectomy in patients with primary breast cancer, little is known about the outcomes of these surgical options in recurrent breast cancer. We investigated differences in overall survival and re-recurrence rates as well as psychosocial outcomes among patients who underwent BCT or mastectomy after the diagnosis of recurrent breast cancer in a single-center setting. METHODS: 124 of 186 eligible patients who underwent surgical treatment for breast cancer recurrence completed the questionnaires on quality of life (EORTC QLQ-C30 and -BR23), fear of progression (PA-F-KF), anxiety and depression (HADS), and body image (BIS)...
March 21, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28301555/risk-factors-for-delay-of-adjuvant-chemotherapy-in-non-metastatic-breast-cancer-patients-a-systematic-review-and-meta-analysis-involving-186982-patients
#2
Xiaofang He, Fen Ye, Bingcheng Zhao, Hailin Tang, Jin Wang, Xiangsheng Xiao, Xiaoming Xie
PURPOSE: Delay performance of adjuvant chemotherapy (AC) after surgery has been presented to affect survival of breast cancer patients adversely, but the risk factors for delay in initiation remain controversial. Therefore, we conducted this systematic review of the literature and meta-analysis aiming at identifying the risk factors for delay of adjuvant chemotherapy (DAC) in non-metastatic breast cancer patients. METHODS: The search was performed on PubMed, Embase, Chinese National Knowledge Infrastructure and Wanfang Database from inception up to July 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28299890/a-case-of-adenomyoepithelioma-of-the-breast-showing-strong-uptake-of-18-f-fluorodeoxyglucose-on-a-positron-emission-tomography
#3
Takaaki Oba, Kazuma Maeno, Mayu Ono, Asumi Iesato, Tokiko Ito, Toshiharu Kanai, Yasuhiro Mochizuki, Ken-Ichi Ito, Akihiko Yoshizawa, Fumiyoshi Takayama
An adenomyoepithelioma of the breast is a rare tumor characterized by biphasic proliferation of both epithelial and myoepithelial cells. This tumor is generally considered as a benign neoplasm, and there are few reports describing the imaging features of this tumor through (18) F-fluorodeoxyglucose positron emission tomography (FDG-PET). Here, we report a case of an adenomyoepithelioma that showed strong uptake of FDG on PET similar to that observed with a malignant tumor. A 73-year-old woman presented to our hospital with a 3...
March 2017: Breast Journal
https://www.readbyqxmd.com/read/28295903/feasibility-of-intraoperative-breast-mri-and-the-role-of-prone-versus-supine-positioning-in-surgical-planning-for-breast-conserving-surgery
#4
Melissa A Mallory, Yasuaki Sagara, Fatih Aydogan, Stephen DeSantis, Jagadeesan Jayender, Diana Caragacianu, Eva Gombos, Kirby G Vosburgh, Ferenc A Jolesz, Mehra Golshan
We assessed the feasibility of supine intraoperative MRI (iMRI) during breast-conserving surgery (BCS), enrolling 15 patients in our phase I trial between 2012 and 2014. Patients received diagnostic prone MRI, BCS, pre-excisional supine iMRI, and postexcisional supine iMRI. Feasibility was assessed based on safety, sterility, duration, and image-quality. Twelve patients completed the study; mean duration = 114 minutes; all images were adequate; no complications, safety, or sterility issues were encountered...
March 10, 2017: Breast Journal
https://www.readbyqxmd.com/read/28292995/-a-case-of-stage-iv-breast-cancer-with-long-term-survival-by-chemotherapy-developing-pulmonary-tumor-thrombotic-microangiopathy-during-the-treatment-course
#5
Kana Kobayashi, Akari Murakami, Saaya Komatsu, Kanako Nishiyama, Michiko Yamashita, Wakana Sugimori, Yoshiaki Kamei, Hiroaki Asai, Akiyoshi Ogimoto, Kazuo Honda, Yasutsugu Takada
Pulmonary tumor thrombotic microangiopathy(PTTM)caused by pulmonary artery microscopic tumor emboli and fibrocellular and/or fibromuscular proliferation leads to progressive pulmonary hypertension and respiratory failure.The prognosis is extremely poor and most patients die shortly after onset.We report a patient with Stage IV breast cancer and long-term survival who developed PTTM during chemotherapy treatment.A 63-year-old woman with multiple metastases in her cerebellum, bone, lung, and lymph node after left breast conserving surgery started to experience dyspnea and malaise 7 years after the surgery...
March 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28292493/patient-preferences-for-minimally-invasive-and-open-locoregional-treatment-for-early-stage-breast-cancer
#6
Floortje M Knuttel, Maurice A A J van den Bosch, Danny A Young-Afat, Marleen J Emaus, Desirée H J G van den Bongard, Arjen J Witkamp, Helena M Verkooijen
BACKGROUND: Noninvasive or minimally invasive treatments are being developed as alternatives to surgery for patients with early-stage breast cancer. Patients' preferences with regard to these new treatments have not been investigated. OBJECTIVES: To assess preferences of patients with breast cancer and of healthy women regarding these new techniques, compared with conventional surgical treatments. METHODS: Six hypothetical breast cancer treatment-outcome scenarios were developed: three standard surgical scenarios (mastectomy, mastectomy with immediate implant-based reconstruction, and breast-conserving therapy [BCT]) and three minimally invasive or noninvasive scenarios (radiofrequency ablation, magnetic resonance-guided high-intensity focused ultrasound ablation, and single-dose ablative radiotherapy)...
March 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28289662/mucosa-associated-lymphoid-tissue-lymphoma-of-the-cecum-and-rectum-a-case-report
#7
Myung Jin Nam, Byung Chang Kim, Sung Chan Park, Chang Won Hong, Kyung Su Han, Dae Kyung Sohn, Weon Seo Park, Hee Jin Chang, Jae Hwan Oh
A colonic mucosa-associated lymphoid-tissue (MALT) lymphoma is relatively rare compared to lymphomas of the stomach or small intestine. We present a case of a MALT lymphoma in the cecum and rectum found during screening colonoscopy. A 54-year-old female, who had undergone right-breast-conserving surgery with axillary dissection due to an invasive ductal carcinoma and a left-breast excisional biopsy due to microcalcification following adjuvant chemoradiation therapy 3 years earlier, was found to have 3-mm-sized smooth elevated lesions in both the cecum and rectum...
February 2017: Annals of Coloproctology
https://www.readbyqxmd.com/read/28284519/breast-conserving-surgery-and-locoregional-control-after-neoadjuvant-chemotherapy
#8
REVIEW
M Teshome, H M Kuerer
The management of breast malignancy and the role of neoadjuvant systemic therapy has continued to evolve over the past 50 years. Survival equivalence with adjuvant systemic therapy is well accepted and demonstrated in several clinical trials. However, strong association with survival outcome and pathologic complete response emerged. Assessment of tumor response, as a surrogate for outcome, continues to be a driver for neoadjuvant therapy with increased applicability in the setting of sophisticated understanding and implications of breast tumor biology and molecular subtype...
February 12, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28282587/feasibility-of-magnetic-marker-localisation-for-non-palpable-breast-cancer
#9
B Schermers, J A van der Hage, C E Loo, M T F D Vrancken Peeters, H A O Winter-Warnars, F van Duijnhoven, B Ten Haken, S H Muller, T J M Ruers
OBJECTIVES: Accurate tumour localisation is essential for breast-conserving surgery of non-palpable tumours. Current localisation technologies are associated with disadvantages such as logistical challenges and migration issues (wire guided localisation) or legislative complexities and high administrative burden (radioactive localisation). We present MAgnetic MArker LOCalisation (MaMaLoc), a novel technology that aims to overcome these disadvantages using a magnetic marker and a magnetic detection probe...
March 7, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28281862/model-based-approach-for-quantitative-estimates-of-skin-heart-and-lung-toxicity-risk-for-left-side-photon-and-proton-irradiation-after-breast-conserving-surgery
#10
Francesco Tommasino, Marco Durante, Vittoria D'Avino, Raffaele Liuzzi, Manuel Conson, Paolo Farace, Giuseppe Palma, Marco Schwarz, Laura Cella, Roberto Pacelli
BACKGROUND: Proton beam therapy represents a promising modality for left-side breast cancer (BC) treatment, but concerns have been raised about skin toxicity and poor cosmesis. The aim of this study is to apply skin normal tissue complication probability (NTCP) model for intensity modulated proton therapy (IMPT) optimization in left-side BC. MATERIAL AND METHODS: Ten left-side BC patients undergoing photon irradiation after breast-conserving surgery were randomly selected from our clinical database...
March 10, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28279888/validation-of-the-electronic-version-of-the-breast-q-in-the-army-of-women-study
#11
Sarah Fuzesi, Stefan J Cano, Anne F Klassen, Dunya Atisha, Andrea L Pusic
Women undergoing surgery for primary breast cancer can choose between breast conserving therapy and mastectomy (with or without breast reconstruction). Patients often turn to outcomes data to help guide the decision-making process. The BREAST-Q is a validated breast surgery-specific patient-reported outcome measure that evaluates satisfaction, quality of life, and patient experience. It was originally developed for paper-and-pencil administration. However, the BREAST-Q has increasingly been administered electronically...
March 6, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28274211/redefining-radiotherapy-for-early-stage-breast-cancer-with-single-dose-ablative-treatment-a-study-protocol
#12
R K Charaghvandi, B van Asselen, M E P Philippens, H M Verkooijen, C H van Gils, P J van Diest, R M Pijnappel, M G G Hobbelink, A J Witkamp, T van Dalen, E van der Wall, T C van Heijst, R Koelemij, M van Vulpen, H J G D van den Bongard
BACKGROUND: A shift towards less burdening and more patient friendly treatments for breast cancer is currently ongoing. In low-risk patients with early-stage disease, accelerated partial breast irradiation (APBI) is an alternative for whole breast irradiation following breast-conserving surgery. MRI-guided single dose ablative APBI has the potential to offer a minimally burdening, non-invasive treatment that could replace current breast-conserving therapy. METHODS: The ABLATIVE study is a prospective, single arm, multicenter study evaluating preoperative, single dose, ablative radiation treatment in patients with early-stage breast cancer...
March 9, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28273552/surgeon-performed-continuous-intraoperative-ultrasound-guidance-decreases-re-excisions-and-mastectomy-rates-in-breast-cancer
#13
Guldeniz Karadeniz Cakmak, Ali U Emre, Oge Tascilar, Burak Bahadir, Selcuk Ozkan
BACKGROUND: Intraoperative ultrasound guided (IUG) breast conserving surgery (BCS) is being increasingly embraced by breast surgeons worldwide. We aimed to compare the efficacy of IUG-BCS for palpable and nonpalpable breast cancer with respect to margin status, re-excision rate, tissue sacrifice and cost-time analysis. METHODS: Intraoperative localization protocol includes intraoperative ultrasound prior to excision to localize the lesion and guide the initial resection...
March 2, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28273157/dosimetric-comparison-of-simultaneous-integrated-boost-with-whole-breast-irradiation-for-early-breast-cancer
#14
Seok Hyun Son, Kyu Hye Choi, Shin-Wook Kim
PURPOSE: The purpose of this study was to identify a more suitable boost plan for simultaneously integrated boost scheme in patients with breast cancer by comparing among 3 types of whole-breast irradiation plus tumor bed boost plans. METHODS: Twenty patients who received radiotherapy following breast-conserving surgery for early breast cancer were enrolled in this study. We performed 1 type of electron plan (E1P plan) and 2 types of 3-dimensional conformal plans using a photon (P3P and P5P plans)...
2017: PloS One
https://www.readbyqxmd.com/read/28272005/bilateral-breast-cancer-after-prophylactic-bilateral-pulmonary-irradiation
#15
Hamrouni A El Meddeb, Jebsi M Chehata, S Kanoun, C Rancoule, J B Guy, N Magne, N Bouaouina
The purpose of this article is to report a new case of a probably radio-induced bilateral breast cancer occurred after prophylactic bilateral pulmonary irradiation in the treatment of osteosarcoma. A 42-year-old woman, treated at the age of 12 years for osteosarcoma at the right lower limb with chemotherapy (methotrexate, adriamycin and cisplatin) followed by non-conservative surgery and adjuvant radiotherapy. Eighteen years after, she developed her first breast cancer, and five years later, her second contralateral breast cancer...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28271747/short-term-outcomes-of-neoadjuvant-hormonal-therapy-versus-neoadjuvant-chemotherapy-in-breast-cancer-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#16
Lei Huang, A-Man Xu
Estrogen receptor positive (ER(+)) breast cancer (BC) is highly hormonal therapy-responsive. The choice between neoadjuvant hormonal therapy (NHT) and neoadjuvant chemotherapy (NCT) remains controversial. The aim of this meta-analysis was to evaluate benefits and safety of NHT compared with NCT for operable BC patients. Areas covered: Electronic databases were searched to identify randomized clinical trials (RCTs) comparing NHT and NCT for treatment of invasive and immunohistochemically ER(+) BC. Major outcomes were clinical response rate, pathologic complete response (pCR), operation methods, recurrence, and adverse events...
March 8, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28270722/does-adjuvant-radiation-therapy-benefit-women-with-small-mammography-detected-breast-cancers
#17
K Jerzak, N Dudalski, K Pritchard, P Sun, S A Narod
BACKGROUND: Women with small nonpalpable breast tumours have an excellent prognosis. The benefit of radiotherapy in this group of low-risk women is unknown. METHODS: A cohort of 1595 women with stages i-iii invasive breast cancer treated with breast-conserving surgery were followed for local recurrence. Using t-tests, baseline demographic data and tumour characteristics were compared for the women who had palpable (n = 1023) and mammography-detected (n = 572) breast cancers...
February 2017: Current Oncology
https://www.readbyqxmd.com/read/28270498/a-randomized-phase-ii-neoadjuvant-study-of-cisplatin-paclitaxel-with-or-without-everolimus-in-patients-with-stage-ii-iii-triple-negative-breast-cancer-tnbc
#18
Bojana Jovanovic, Ingrid A Mayer, Erica L Mayer, Vandana G Abramson, Aditya Bardia, Melinda Sanders, Maria G Kuba, Monica Valeria Estrada, J Scott Beeler, Timothy M Shaver, Kimberly N Johnson, Violeta Sanchez, Jennifer M Rosenbluth, Patrick M Dillon, Andres Forrero-Torres, Jenny C Chang, Ingrid Meszoely, Ana Grau, Brian D Lehmann, Yu Shyr, Quanhu Sheng, Sheau-Chiann Chen, Carlos L Arteaga, Jennifer A Pietenpol
PURPOSE: Due to inherent disease heterogeneity, targeted therapies have eluded TNBC, and biomarkers predictive of treatment response have not yet been identified. This study was designed to determine if the mTOR inhibitor everolimus with cisplatin and paclitaxel would provide synergistic anti-tumor effects in TNBC. EXPERIMENTAL DESIGN: Stage II/III patients with TNBC were enrolled in a randomized phase II trial of preoperative weekly cisplatin, paclitaxel and daily everolimus or placebo for 12 weeks, until definitive surgery...
March 7, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28270181/weekly-taxane-anthracycline-combination-regimen-versus-tri-weekly-anthracycline-based-regimen-for-the-treatment-of-locally-advanced-breast-cancer-a-randomized-controlled-trial
#19
Qiu-Wen Tan, Ting Luo, Hong Zheng, Ting-Lun Tian, Ping He, Jie Chen, He-Lin Zeng, Qing Lv
BACKGROUND: Extensive studies have confirmed the efficacy of taxanes in combination with anthracycline-based chemotherapy on breast cancer. However, few studies have assessed the efficacy of weekly taxane-anthracycline regimens on locally advanced breast cancer. This study was to compare the efficacy and safety of a weekly taxane-anthracycline regimen with those of tri-weekly anthracycline-based regimen in patients with locally advanced breast cancer. METHODS: Patients with locally advanced breast cancer were randomized to receive 4-6 cycles of neoadjuvant chemotherapy with tri-weekly 5-fluorouracil-epirubicin-cyclophosphamide (FEC) regimen or weekly paclitaxel-epirubicin (PE) regimen...
March 7, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28267696/cutaneous-radiation-associated-breast-angiosarcoma-radicality-of-surgery-impacts-survival
#20
George Z Li, Mark Fairweather, Jiping Wang, Dennis P Orgill, Monica M Bertagnolli, Chandrajit P Raut
OBJECTIVE: Cutaneous radiation therapy (RT)-associated breast angiosarcoma (AS) is a rare consequence of breast RT associated with poor outcomes. Previous small case series have documented high recurrence rates and poor survival. We reviewed our experience and focused on the impact of conservative versus radical resections. METHODS: Data for patients with RT-associated breast AS evaluated at our institution from 1993 to 2015 who underwent surgery were reviewed. RESULTS: Seventy-six women were diagnosed with RT-associated breast AS at a median 85 months from surgery for invasive breast carcinoma or ductal carcinoma in situ...
April 2017: Annals of Surgery
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