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Breast Conservative Surgery

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https://www.readbyqxmd.com/read/27926499/breast-carcinoma-in-situ-an-observational-study-of-tumor-subtype-treatment-and-outcomes
#1
Qi Wu, Juanjuan Li, Si Sun, Shan Zhu, Chuang Chen, Juan Wu, Qian Liu, Wen Wei, Shengrong Sun
BACKGROUND & AIMS: To evaluate the clinical presentation, treatment and outcome of patients with breast carcinoma in situ (BCIS) with special emphasis on the role of the tumor subtype and local treatment in these patients. METHODS: Using data obtained by the Surveillance, Epidemiology, and End Results (SEER) program from 2010-2013, a retrospective, population-based cohort study was conducted to investigate tumor subtype-specific differences in various characteristics, overall survival (OS) and breast cancer-specific mortality (BCSM)...
December 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/27923403/determinants-for-patient-satisfaction-regarding-aesthetic-outcome-and-skin-sensitivity-after-breast-conserving-surgery
#2
Cecilia Dahlbäck, Jonas Manjer, Martin Rehn, Anita Ringberg
BACKGROUND: With the development of new surgical techniques in breast cancer, such as oncoplastic breast surgery, increased knowledge of risk factors for poor satisfaction with conventional breast-conserving surgery (BCS) is needed in order to determine which patients to offer these techniques to. The aim of this study was to investigate patient satisfaction regarding aesthetic result and skin sensitivity in relation to patient, tumour, and treatment factors, in a consecutive sample of patients undergoing conventional BCS...
December 7, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27922844/prediction-of-acute-postoperative-pain-following-breast-cancer-surgery-using-the-pain-sensitivity-questionnaire-a-cohort-study
#3
Benno Rehberg, Stanislas Mathivon, Christophe Combescure, Yannick Mercier, Georges L Savoldelli
OBJECTIVES: Previous studies have indicated that preoperative pain sensitivity correlates with postoperative pain intensity, and thus may be used to predict severe postoperative pain. Self-rating of pain sensitivity using the "Pain Sensitivity Questionnaire (PSQ)" may be an adjunct to these measures. METHODS: We tested the predictive ability of the PSQ as well as experimental parameters of pain sensitivity and other known risk factors for acute pain in 198 patients scheduled for breast cancer surgery...
January 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/27922843/persistent-breast-pain-among-women-with-histories-of-breast-conserving-surgery-for-breast-cancer-compared-with-women-without-histories-of-breast-surgery-or-cancer
#4
Sara N Edmond, Rebecca A Shelby, Francis J Keefe, Hannah M Fisher, John E Schmidt, Mary S Soo, Celette S Skinner, Gretchen M Ahrendt, Jessica Manculich, Jules H Sumkin, Margarita L Zuley, Dana H Bovbjerg
OBJECTIVES: This study compared persistent breast pain among women who received breast-conserving surgery for breast cancer and women without a history of breast cancer. METHODS: Breast cancer survivors (n=200) were recruited at their first postsurgical surveillance mammogram (6 to 15 mo postsurgery). Women without a breast cancer history (n=150) were recruited at the time of a routine screening mammogram. All women completed measures of breast pain, pain interference with daily activities and intimacy, worry about breast pain, anxiety symptoms, and depression symptoms...
January 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/27920628/local-recurrence-after-breast-conserving-surgery-and-mastectomy-following-neoadjuvant-chemotherapy-for-locally-advanced-breast-cancer-a-meta-analysis
#5
REVIEW
Xiaodong Zhou, Yujie Li
BACKGROUND: Breast-conserving surgery (BCS) in patients with large tumors shrunk by neoadjuvant chemotherapy (NCT) remains controversial. We conducted a meta-analysis to evaluate the local recurrence rates in locally advanced breast cancer (LABC) patients receiving NCT comparing BCS with mastectomy. METHODS: Pubmed, Web of Knowledge, and Ovid's database were searched for studies concerning treatment for LABC from January 2000 to June 2015. A meta-analysis was performed to compare the recurrence rates of patients receiving BCS versus mastectomy following NCT...
October 2016: Breast Care
https://www.readbyqxmd.com/read/27916314/intraoperative-ultrasound-guidance-in-breast-conserving-surgery-shows-superiority-in-oncological-outcome-long-term-cosmetic-and-patient-reported-outcomes-final-outcomes-of-a-randomized-controlled-trial-cobalt
#6
J H Volders, M H Haloua, N M A Krekel, V L Negenborn, R H E Kolk, A M F Lopes Cardozo, A M Bosch, L M de Widt-Levert, H van der Veen, H Rijna, A H M Taets van Amerongen, K Jóźwiak, S Meijer, M P van den Tol
BACKGROUND: The multicenter randomized controlled COBALT trial demonstrated that ultrasound-guided breast-conserving surgery (USS) results in a significant reduction of margin involvement (3.1% vs. 13%) and excision volumes compared to palpation-guided surgery (PGS). The aim of the present study was to determine long term oncological and patient-reported outcomes including quality of life (QoL), together with their progress over time. METHODS: 134 patients with T1-T2 breast cancer were randomized to USS (N = 65) or PGS (N = 69)...
November 23, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27915203/adjuvant-radiation-therapy-and-survival-for-adenoid-cystic-carcinoma-of-the-breast
#7
Jia-Yuan Sun, San-Gang Wu, Shan-Yu Chen, Feng-Yan Li, Huan-Xin Lin, Yong-Xiong Chen, Zhen-Yu He
PURPOSE: The assess the clinical value of different types of surgical procedures and further analyze the effect of adjuvant radiation therapy (RT) for adenoid cystic carcinoma (ACC) of the breast. METHODS: Patients with ACC of the breast were identified using a population-based national registration database (Surveillance, Epidemiology, and End Results, SEER). The Kaplan-Meier method and Cox regression models were performed to determine the impact of the surgical procedures and adjuvant RT associated with cause-specific survival (CSS) and overall survival (OS)...
December 1, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27908586/standard-wide-local-excision-or-bilateral-reduction-mammoplasty-in-large-breasted-women-with-small-tumours-surgical-and-patient-reported-outcomes
#8
R Di Micco, R L O'Connell, P A Barry, N Roche, F A MacNeill, J E Rusby
INTRODUCTION: Oncoplastic breast surgery is used to extend the role of breast-conserving surgery (BCS) to women with an unfavourable tumour to breast volume ratio. However, large-breasted women with a relatively small breast cancer may be offered bilateral reduction mammoplasty (BRM) despite being suitable for standard BCS as the more complex surgery may have advantages in terms of patient satisfaction and reduced adverse effects of radiotherapy. PATIENT AND METHODS: This retrospective study evaluated surgical and patient-reported outcome measures (PROMs) in large-breasted women with early (<3 cm) breast cancer, who have undergone unilateral standard BCS or BRM...
November 17, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27901596/magnetic-resonance-imaging-in-the-pre-surgical-staging-of-breast-cancer-our-experience
#9
Paola Rabasco, Rocchina Caivano, Giuseppina Dinardo, Matilde Gioioso, Antonella Lotumolo, Giancarlo Iannelli, Antonio Villonio, Giuseppe La Torre, Stefano D'Errico, Luca Macarini, Giuseppe Guglielmi, Aldo Cammarota
PURPOSE: To investigate the clinical impact of magnetic resonance imaging (MRI) in the detection of multifocal-multicentric breast cancers, already identified by mammography and ultrasound, and analyzed histologically, to evaluate its role in preoperative staging. MATERIALS AND METHODS: From January 2012 to February 2014, 188 patients, aged 28 to 74 years, newly diagnosed with breast cancer on conventional imaging (mammography and ultrasound) were enrolled. They underwent preoperative contrast-enhanced 3T MRI...
November 30, 2016: Cancer Investigation
https://www.readbyqxmd.com/read/27900632/breast-conserving-surgery-alone-for-ductal-carcinoma-in-situ-factors-associated-with-increased-risk-of-local-recurrence
#10
Alessandra Mele, Pritesh Mehta, Priscilla J Slanetz, Alexander Brook, Abram Recht, Ranjna Sharma
PURPOSE: This retrospective study was aimed at identifying clinicopathologic characteristics associated with an increased risk for ipsilateral local recurrence (LR) in patients with ductal carcinoma in situ (DCIS) treated with wide local excision (WLE) alone without radiotherapy (RT). METHODS: All patients with DCIS treated with WLE alone at the Beth Israel Deaconess Medical Center, Boston, MA, USA, between the years 2000 and 2010 were identified. We collected data on demographics, parity, personal or family history of breast cancer, exogenous hormone use, tobacco use, comorbidities, genetic mutation carrier status, imaging interval, and tumor-specific characteristics...
November 29, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27900058/effect-of-surgical-wound-fluids-after-intraoperative-electron-radiotherapy-on-the-cancer-stem-cell-phenotype-in-a-panel-of-human-breast-cancer-cell-lines
#11
Karolina Zaleska, Wiktoria Maria Suchorska, Anna Przybyła, Dawid Murawa
The wound healing process after surgery alters the area surrounding the original tumor and around the scar, and the modified microenvironment is more favorable for tumor recurrence. Intraoperative radiotherapy (IORT) is one of the more novel strategies in breast cancer (BC) treatment. Irradiation during surgery has effects on the tumor microenvironment, abrogating the proliferative cascade induced by surgical wound healing. The aim of the present study was to determine the effect of surgical wound fluids from IOERT treatment (RT-WF) compared with wound fluids from conservative-breast surgery only (WF) on the cancer stem cell phenotype in a panel of BC cell lines...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27899083/tumor-characteristics-and-prognosis-in-familial-breast-cancer
#12
G Arpino, M Pensabene, C Condello, R Ruocco, I Cerillo, R Lauria, V Forestieri, M Giuliano, C De Angelis, M Montella, A Crispo, S De Placido
BACKGROUND: Approximately 5-10% of breast cancers are hereditary and their biology and prognosis appear to differ from those of sporadic breast cancers. In this study we compared the biological features and clinical characteristics of non metastatic breast cancer in patients with BRCA mutations versus patients with a family history suggesting hereditary breast cancer but without BRCA mutations (BRCA wild type) versus patients with sporadic disease, and correlated these findings with clinical outcome...
November 29, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27898991/nipple-and-areola-sparing-mastectomy-for-the-treatment-of-breast-cancer
#13
REVIEW
Bruna S Mota, Rachel Riera, Marcos Desidério Ricci, Jessica Barrett, Tiago B de Castria, Álvaro N Atallah, Jose Luiz B Bevilacqua
BACKGROUND: The efficacy and safety of nipple-sparing mastectomy and areola-sparing mastectomy for the treatment of breast cancer are still questionable. It is estimated that the local recurrence rates following nipple-sparing mastectomy are very similar to breast-conserving surgery followed by radiotherapy. OBJECTIVES: To assess the efficacy and safety of nipple-sparing mastectomy and areola-sparing mastectomy for the treatment of ductal carcinoma in situ and invasive breast cancer in women...
November 29, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27898749/-dosimetric-comparison-of-different-techniques-for-external-beam-accelerated-partial-breast-irradiation
#14
Gábor Stelczer, Tibor Major, Norbert Mészáros, Csaba Polgár, Csilla Pesznyák
The aim of this article is to evaluate and compare four different radiotherapy techniques of accelerated partial breast irradiation (APBI) considering planning quality, dosimetric and practical aspects. The investigated techniques are three dimensional conformal radiotherapy (3D-CRT), "step and shoot" (SS) and "sliding window" (SW) intensity-modulated radiotherapy, intensity-modulated arc therapy (RA). CT scans of 10 patients previously treated with APBI were selected for the study. Surgical clips were placed on the borders of the tumour bed during breast conserving surgery...
November 29, 2016: Magyar Onkologia
https://www.readbyqxmd.com/read/27897024/-peripheral-precocious-puberty
#15
J Zvonařová Skalická, R Pilka
OBJECTIVE: To summarize literature data on peripheral precocious puberty. DESIGN: A literature review. SETTING: Středomoravská nemocniční a.s., hospital Šternberk, Department of Obstetrics and Gynaecology, University Hospital, Medical Faculty, Palacky University, Olomouc. METHODS AND RESULTS: We searched in PubMed using the key words stated below according to date and published since 1980.Peripheral precocious puberty occurs in girls with the frequency 1:400-1000...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27894703/over-surgery-in-breast-cancer
#16
Fiona MacNeill, Andreas Karakatsanis
Breast surgery remains the original and most effective 'targeted' therapy: excision of early cancer is curative and for more advanced disease surgery improves local disease control. However in well intentioned pursuit of cure and local disease control, some cancers are over-treated resulting in major physical and emotional morbidity. Less breast surgery is safe, as evidenced by steady reductions in mortality and local recurrence; earlier diagnosis and widespread use of systemic therapies and radiotherapy have allowed more conservative surgery...
November 25, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27892665/thyroid-function-after-postoperative-radiation-therapy-in-patients-with-breast-cancer
#17
Edyta Wolny-Rokicka, Andrzej Tukiendorf, Jerzy Wydmański, Danuta Roszkowska, Bogusław Staniul, Agnieszka Zembroń-Łacny
Objective: The aim of this study was to assess thyroid function in breast cancer patients exposed to therapeutic external beam radiation. The focus was on possible progressive changes and any relationships between the incidence of primary hypothyroidism, the time required to become hypothyroid, and factors such as chemotherapy, hormonotherapy and immunotherapy. Materials and Methods: Seventy females undergoing 3D conformal and IMRT radiation therapy for breast cancers were enrolled in a non-randomized prospective study...
January 10, 2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27891392/a-study-of-evaluation-and-management-of-rare-congenital-breast-diseases
#18
Rikki Singal, Sudhir Kumar Mehta, Jyoti Bala, Muzzafar Zaman, Amit Mittal, Guarav Gupta, Samer Rudra, Samita Singal
INTRODUCTION: Polymastia and polythelia may be asymptomatic or cause pain, restriction of arm movement, milk discharge, cosmetic problems or anxiety. Cosmesis is the main indication for surgical excision of accessory breasts in axilla. In addition it also confirms the diagnosis and allays the patient's fear of harbouring a malignancy. AIM: To evaluate the presentation of symptoms, investigations required for diagnosis and the management to improve the treatment protocols in patients with breast diseases...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27889438/disparities-in-surgical-treatment-of-early-stage-breast-cancer-among-female-residents-of-texas-the-role-of-racial-residential-segregation
#19
Chinedum O Ojinnaka, Wen Luo, Marcia G Ory, Darcy McMaughan, Jane N Bolin
INTRODUCTION: Early-stage breast cancer can be surgically treated by using mastectomy or breast-conserving surgery and adjuvant radiotherapy, also known as breast-conserving therapy (BCT). Little is known about the association between racial residential segregation, year of diagnosis, and surgical treatment of early-stage breast cancer, and whether racial residential segregation influences the association between other demographic characteristics and disparities in surgical treatment...
October 19, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/27885679/clinical-auditing-as-an-instrument-for-quality-improvement-in-breast-cancer-care-in-the-netherlands-the-national-nabon-breast-cancer-audit
#20
Annelotte C M van Bommel, Pauline E R Spronk, Marie-Jeanne T F D Vrancken Peeters, Agnes Jager, Marc Lobbes, John H Maduro, Marc A M Mureau, Kay Schreuder, Carolien H Smorenburg, Janneke Verloop, Pieter J Westenend, Michel W J M Wouters, Sabine Siesling, Vivianne C G Tjan-Heijnen, Thijs van Dalen
BACKGROUND: In 2011, the NABON Breast Cancer Audit (NBCA) was instituted as a nation-wide audit to address quality of breast cancer care and guideline adherence in the Netherlands. The development of the NBCA and the results of 4 years of auditing are described. METHODS: Clinical and pathological characteristics of patients diagnosed with invasive breast cancer or in situ carcinoma (DCIS) and information regarding diagnosis and treatment are collected in all hospitals (n = 92) in the Netherlands...
November 25, 2016: Journal of Surgical Oncology
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