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Ph sensitive liposomes

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https://www.readbyqxmd.com/read/28704679/ph-sensitive-polymer-modified-liposome-based-immunity-inducing-system-effects-of-inclusion-of-cationic-lipid-and-cpg-dna
#1
Yuta Yoshizaki, Eiji Yuba, Naoki Sakaguchi, Kazunori Koiwai, Atsushi Harada, Kenji Kono
Efficient vaccine carriers for cancer immunotherapy require two functions: antigen delivery to dendritic cells (DCs) and the activation of DCs, a so-called adjuvant effect. We previously reported antigen delivery system using liposomes modified with pH-sensitive polymers, such as 3-methylglutarylated hyperbranched poly(glycidol) (MGlu-HPG), for the induction of antigen-specific immune responses. We reported that inclusion of cationic lipids to MGlu-HPG-modified liposomes activates DCs and enhances antitumor effects...
July 3, 2017: Biomaterials
https://www.readbyqxmd.com/read/28671767/emergence-of-gold-mesoporous-silica-hybrid-nanotheranostics-dox-encoded-folate-targeted-chemotherapy-with-modulation-of-sers-fingerprinting-for-apoptosis-toward-tumor-eradication
#2
Adukkadan N Ramya, Manu M Joseph, Santhi Maniganda, Varsha Karunakaran, Sreelekha T T, Kaustabh Kumar Maiti
Strategically fabricated theranostic nanocarrier delivery system is an unmet need in personalized medicine. Herein, this study reports a versatile folate receptor (FR) targeted nanoenvelop delivery system (TNEDS) fabricated with gold core silica shell followed by chitosan-folic acid conjugate surface functionalization by for precise loading of doxorubicin (Dox), resembled as Au@SiO2 -Dox-CS-FA. TNEDS possesses up to 90% Dox loading efficiency and internalized through endocytosis pathway leading to pH and redox-sensitive release kinetics...
July 3, 2017: Small
https://www.readbyqxmd.com/read/28638626/effects-of-liposomal-curcumin-on-five-opportunistic-bacterial-strains-found-in-the-equine-hindgut-preliminary-study
#3
S D Bland, E B Venable, J L McPherson, R L Atkinson
BACKGROUND: The horse intestinal tract is sensitive and contains a highly complex microbial population. A shift in the microbial population can lead to various issues such as inflammation and colic. The use of nutraceuticals in the equine industry is on the rise and curcumin is thought to possess antimicrobial properties that may help to minimize the proliferation of opportunistic bacteria. METHODS: Four cecally-cannulated horses were utilized to determine the optimal dose of liposomal-curcumin (LIPC) on reducing Streptococcus bovis/equinus complex (SBEC), Escherichia coli K-12, Escherichia coli general, Clostridium difficile, and Clostridium perfringens in the equine hindgut without adversely affecting cecal characteristics...
2017: Journal of Animal Science and Technology
https://www.readbyqxmd.com/read/28580308/a-novel-approach-on-drug-delivery-investigation-of-a-new-nano-formulation-of-liposomal-doxorubicin-and-biological-evaluation-of-entrapped-doxorubicin-on-various-osteosarcoma-cell-lines
#4
Fateme Haghiralsadat, Ghasem Amoabediny, Mohammad Hasan Sheikhha, Tymour Forouzanfar, Marco N Helder, Behrouz Zandieh-Doulabi
OBJECTIVE: In this study we prepared a novel formulation of liposomal doxorubicin (L- DOX). The drug dose was optimized by analyses of cellular uptake and cell viability of osteosarcoma (OS) cell lines upon exposure to nanoliposomes that contained varying DOX concentrations. We intended to reduce the cytotoxicity of DOX and improve characteristics of the nanosystems. MATERIALS AND METHODS: In this experimental study, we prepared liposomes by the pH gradient hydration method...
2017: Cell Journal
https://www.readbyqxmd.com/read/28546107/intestinal-toxicity-evaluation-of-long-circulating-and-ph-sensitive-liposomes-loaded-with-cisplatin
#5
Raquel Silva Araújo, Ana Letícia Malheiros Silveira, Éricka Lorenna de Sales E Souza, Rachel Horta Freire, Cristina Maria de Souza, Diego Carlos Reis, Bruno Rocha Cordeiro Costa, Michelle Amantéa Sugimoto, Josianne Nicácio Silveira, Flaviano Dos Santos Martins, Geovanni Dantas Cassali, Jacqueline Isaura Alvarez Leite, Lirlândia Pires Sousa, Adaliene Versiani Matos Ferreira, Mônica Cristina Oliveira, Valbert Nascimento Cardoso
Cisplatin (CDDP) is a chemotherapeutic agent widely used in several anticancer protocols for instance head and neck, testicle, ovarian, lung and peritoneal carcinomatosis. According to the literature, the use of CDDP is associated with several side effects; among them, we highlighted the mucositis. CDDP, when administered by IP, promoted significant intestinal epithelium alterations in an experimental model. Our research group has proposed that the incorporation of CDDP into long-circulating and pH-sensitive liposomes (SpHL-CDDP) could help to overcome some side effects induced by this drug...
August 30, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28528212/targeted-co-delivery-of-polypyrrole-and-rapamycin-by-trastuzumab-conjugated-liposomes-for-combined-chemo-photothermal-therapy
#6
Hanh Thuy Nguyen, Tuan Hiep Tran, Raj Kumar Thapa, Cao Dai Phung, Beom Soo Shin, Jee-Heon Jeong, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
Trastuzumab is a therapeutic monoclonal antibody that selectively recognizes HER2/neu receptor for targeting breast cancers. In this study, we aimed to present a strategy to combine chemo and phototherapy and targeted delivery via monoclonal antibody for enhanced anticancer effects. We co-loaded a chemotherapeutic agent, rapamycin, and a photosensitizer, polypyrrole, in trastuzumab-conjugated liposomes (LRPmAb) for combined chemo-photothermal therapy. LRPmAb had small size (172.2±9.6nm), narrow distribution, and negative ζ-potential (-12...
May 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28493521/a-freeze-concentration-and-polyampholyte-modified-liposome-based-antigen-delivery-system-for-effective-immunotherapy
#7
Sana Ahmed, Satoshi Fujita, Kazuaki Matsumura
Immunotherapy is an exciting new approach to cancer treatment. The development of a novel freeze-concentration method is described that could be applicable in immunotherapy. The method involves freezing cells in the presence of pH-sensitive, polyampholyte-modified liposomes with encapsulated ovalbumin (OVA) as the antigen. In RAW 264.7 cells, compared to unfrozen, freeze-concentration of polyampholyte-modified liposomes encapsulating OVA resulted in efficient OVA uptake and also allowed its delivery to the cytosol...
May 11, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28471676/protonation-kinetics-compromise-liposomal-fluorescence-assay-of-membrane-permeation
#8
Deniz Sezer, Tuğçe Oruç
The membrane permeation of weak acids and bases couples to the ambient pH and can be studied using pH-sensitive dyes as reporters. Such fluorescence measurements with aliphatic amine drugs have revealed biexponential kinetics of permeation into liposomes (Eyer et al. J. Controlled Release 2014, 173, 102). Permeability coefficients have been obtained using the faster of the two kinetic components. Here, the origin of the biexponential kinetics is studied with a kinetic rate model that in addition to drug permeation accounts for the protonation of the drug and the dye...
May 16, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28463812/preparation-of-dual-stimuli-responsive-liposomes-using-methacrylate-based-copolymers-with-ph-and-temperature-sensitivities-for-precisely-controlled-release
#9
Takumi Sugimoto, Naoko Yamazaki, Takaaki Hayashi, Eiji Yuba, Atsushi Harada, Aki Kotaka, Chiharu Shinde, Takayuki Kumei, Yasushi Sumida, Mitsuhiro Fukushima, Yuki Munekata, Keiichi Maruyama, Kenji Kono
Dual-signal-sensitive copolymers were synthesized by copolymerization of methoxy diethylene glycol methacrylate, methacrylic acid, and lauroxy tetraethylene glycol methacrylate, which respectively provide temperature sensitivity, pH sensitivity, and anchoring to liposome surfaces. These novel copolymers, with water solubility that differs depending on temperature and pH, are soluble in water under neutral pH and low-temperature conditions, but they become water-insoluble and form aggregates under acidic pH and high-temperature conditions...
April 23, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28452577/novel-nano-sized-liposome-encapsulated-polyamidoamine-dendrimer-derivatives-facilitate-tumour-targeting-by-overcoming-the-polyethylene-glycol-dilemma-and-integrin-saturation-obstacle
#10
Gang Li, Yan-Zhi Song, Zhen-Jun Huang, Kang Chen, Da-Wei Chen, Yi-Hui Deng
Drug delivery systems (DDSs) commonly employ arginine-glycine-aspartic acid (RGD) peptides with polyethylene glycol (PEG)-dependent enhanced permeability and retention (EPR) effect to optimise tumour-targeting. However, the PEG dilemma and integrin saturation obstacle are major challenges. To address these issues, we constructed a novel, nano-sized DDS by encapsulating doxorubicin (DOX)-loaded folic acid derivatives of polyamidoamine dendrimer (PAMAM G5.0) in cyclic RGD-tyrosine-lysine pentapeptide (c[RGDyK])-modified liposomes (RGD-SL[FND/DOX]), prepared using thin-film hydration, film-dispersion and hydration-sonication...
September 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28442909/tat-functionalized-liposomes-for-the-treatment-of-meningitis-an-in-vitro-study
#11
Caterina Bartomeu Garcia, Di Shi, Thomas J Webster
Bacterial meningitis has become a global concern, because of the emergence of antibiotic-resistant bacteria. It has been demonstrated that liposomes can enter bacteria, thus providing a possible treatment for numerous infections, including meningitis. Fusogenic liposomes are pH-sensitive with a high capacity to fuse with the bacteria membrane and promote intracellular drug release. Moreover, this ability can be improved by using cell-penetrating peptides (such as Tat47-57, which is a peptide derived from the Tat protein of HIV)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28415842/spectrophotometric-quantification-of-peroxidase-with-p-phenylene-diamine-for-analyzing-peroxidase-encapsulating-lipid-vesicles
#12
Ya Zhang, Yannick R F Schmid, Sandra Luginbühl, Qiang Wang, Petra S Dittrich, Peter Walde
A spectrophotometric assay for the determination of horseradish peroxidase (HRP) in aqueous solution with p-phenylenediamine (PPD, benzene-1,4-diamine) as electron donor substrate and hydrogen peroxide (H2O2) as oxidant was developed. The oxidation of PPD by HRP/H2O2 leads to the formation of Bandrowski's base ((3E,6E)-3,6-bis[(4-aminophenyl)imino]cyclohexa-1,4-diene-1,4-diamine), which can be quantified by following the increase in absorbance at 500 nm. The assay was applied for monitoring the activity of HRP inside ≈180 nm-sized lipid vesicles (liposomes), prepared from POPC (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine) and purified by size exclusion chromatography...
May 3, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28405163/enhancing-sirna-based-cancer-therapy-using-a-new-ph-responsive-activatable-cell-penetrating-peptide-modified-liposomal-system
#13
Bai Xiang, Xue-Li Jia, Jin-Long Qi, Li-Ping Yang, Wei-Hong Sun, Xiao Yan, Shao-Kun Yang, De-Ying Cao, Qing Du, Xian-Rong Qi
As a potent therapeutic agent, small interfering RNA (siRNA) has been exploited to silence critical genes involved in tumor initiation and progression. However, development of a desirable delivery system is required to overcome the unfavorable properties of siRNA such as its high degradability, molecular size, and negative charge to help increase its accumulation in tumor tissues and promote efficient cellular uptake and endosomal/lysosomal escape of the nucleic acids. In this study, we developed a new activatable cell-penetrating peptide (ACPP) that is responsive to an acidic tumor microenvironment, which was then used to modify the surfaces of siRNA-loaded liposomes...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28343016/evaluation-of-antitumor-activity-and-cardiac-toxicity-of-a-bone-targeted-ph-sensitive-liposomal-formulation-in-a-bone-metastasis-tumor-model-in-mice
#14
Diego Dos Santos Ferreira, Bruno Luís Jesus de Oliveira Pinto, Vidhya Kumar, Valbert Nascimento Cardoso, Simone Odília Fernandes, Cristina Maria Souza, Geovanni Dantas Cassali, Anna Moore, David E Sosnovik, Christian T Farrar, Elaine Amaral Leite, Ricardo José Alves, Mônica Cristina de Oliveira, Alexander Ramos Guimarães, Peter Caravan
Chemotherapy for bone tumors is a major challenge because of the inability of therapeutics to penetrate dense bone mineral. We hypothesize that a nanostructured formulation with high affinity for bone could deliver drug to the tumor while minimizing off-target toxicity. Here, we evaluated the efficacy and toxicity of a novel bone-targeted, pH-sensitive liposomal formulation containing doxorubicin in an animal model of bone metastasis. Biodistribution studies with the liposome showed good uptake in tumor, but low accumulation of doxorubicin in the heart...
July 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28255230/reversal-of-multidrug-resistance-in-human-lung-cancer-cells-by-delivery-of-3-octadecylcarbamoylacrylic-acid-cisplatin-based-liposomes
#15
Juan Song, Weifang Ren, Tingting Xu, Yi Zhang, Hongyu Guo, Shanshan Zhu, Li Yang
Liposome-based drug delivery system would be an innovative and promising candidate to circumvent multidrug resistance (MDR) of cisplatin (CDDP). However, the reversal efficacy of liposomal CDDP was severely impaired by weak cellular uptake and insufficient intracellular drug release. In this study, 3-octadecylcarbamoylacrylic acid-CDDP nanocomplex (OMI-CDDP-N)-based liposomes (OCP-L) with high cellular uptake and sufficient intracellular drug release were designed to circumvent MDR of lung cancer. OMI-CDDP-N was synthesized through a pH-sensitive monocarboxylato and an O→Pt coordinate bond, which is more efficient than CDDP...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28223799/hypoxia-responsive-ionizable-liposome-delivery-sirna-for-glioma-therapy
#16
Hong-Mei Liu, Ya-Fei Zhang, Yan-Dong Xie, Yi-Fan Cai, Bai-Yang Li, Wen Li, Ling-Yu Zeng, Yu-Ling Li, Ru-Tong Yu
Here, we report the hypoxia-responsive ionizable liposomes to deliver small interference RNA (siRNA) anticancer drugs, which can selectively enhance cellular uptake of the siRNA under hypoxic and low-pH conditions to cure glioma. For this purpose, malate dehydrogenase lipid molecules were synthesized, which contain nitroimidazole groups that impart hypoxia sensitivity and specificity as hydrophobic tails, and tertiary amines as hydrophilic head groups. These malate dehydrogenase molecules, together with DSPE-PEG2000 and cholesterol, were self-assembled into O'(1),O(1)-(3-(dimethylamino)propane-1,2-diyl) 16-bis(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl) di(hexadecanedioate) liposomes (MLP) to encapsulate siRNA through electrostatic interaction...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28214630/ph-and-reduction-dual-responsive-dipeptide-cationic-lipids-with-%C3%AE-tocopherol-hydrophobic-tail-for-efficient-gene-delivery
#17
Qiang Liu, Rong-Chuan Su, Wen-Jing Yi, Li-Ting Zheng, Shan-Shan Lu, Zhi-Gang Zhao
A series of tocopherol-based cationic lipid 3a-3f bearing a pH-sensitive imidazole moiety in the dipeptide headgroup and a reduction-responsive disulfide linkage were designed and synthesized. Acid-base titration of these lipids showed good buffering capacities. The liposomes formed from 3 and co-lipid 1, 2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) could efficiently bind and condense DNA into nanoparticles. Gel binding and HPLC assays confirmed the encapsulated DNA could release from lipoplexes 3 upon addition of 10 mM glutathione (GSH)...
March 31, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28198148/stimuli-responsive-liposomes-for-drug-delivery
#18
REVIEW
Y Lee, D H Thompson
The ultimate goal of drug delivery is to increase the bioavailability and reduce the toxic side effects of the active pharmaceutical ingredient (API) by releasing them at a specific site of action. In the case of antitumor therapy, association of the therapeutic agent with a carrier system can minimize damage to healthy, nontarget tissues, while limit systemic release and promoting long circulation to enhance uptake at the cancerous site due to the enhanced permeation and retention effect (EPR). Stimuli-responsive systems have become a promising way to deliver and release payloads in a site-selective manner...
February 15, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28150195/multifunctional-liposomes
#19
Bhawani Aryasomayajula, Giuseppina Salzano, Vladimir P Torchilin
Liposomes have come a long way since their conception in the 1960s, when they were envisioned primarily for drug delivery. Besides serving the important function of the delivery of a variety of drugs, liposomes offer a platform for the co-delivery of a range of therapeutic and diagnostic agents with different physicochemical properties. They are also amenable to the addition of various targeting moieties such as proteins, sugars, and antibodies for selective targeting at a desired site, including tumors. Currently, the design of stimuli-sensitive liposomes for drug delivery is a lively area of research...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28120466/new-liposomal-doxorubicin-nanoformulation-for-osteosarcoma-drug-release-kinetic-study-based-on-thermo-and-ph-sensitivity
#20
Fateme Haghiralsadat, Ghasem Amoabediny, Mohammad Hasan Sheikhha, Behrouz Zandieh-Doulabi, Samira Naderinezhad, Marco N Helder, Tymour Forouzanfar
A novel approach was developed for the preparation of stealth controlled-release liposomal doxorubicin. Various liposomal formulations were prepared by employing both thin film and pH gradient hydration techniques. The optimum formulation contained phospholipid and cholesterol in 1:0.43 molar ratios in the presence of 3% DSPE-mPEG (2000). The liposomal formulation was evaluated by determining mean size of vesicle, encapsulation efficiency, polydispersity index, zeta potentials, carrier's functionalization and surface morphology...
January 25, 2017: Chemical Biology & Drug Design
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