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https://www.readbyqxmd.com/read/29341060/rationale-of-decreasing-low-density-lipoprotein-cholesterol-below-70-mg-dl-in-patients-with-coronary-artery-disease-a-retrospective-virtual-histology-intravascular-ultrasound-study
#1
Young Hoon Seo, Duck-Jun Seo, In Geol Song, Ki-Hong Kim, Taek-Geun Kwon, Jang-Ho Bae
BACKGROUND: The associations between statin and coronary plaque compositional changes were reported according to the use of high dose or not. An evaluation of the impact of low-density lipoprotein cholesterol (LDL-C) < 70 mg/dL by using real world dosages of statin on coronary plaque composition was undertaken. METHODS: The study subjects consisted of 61 patients (mean 59.9 years old, 45 males) who underwent percutaneous coronary intervention, baseline and follow-up (F/U; mean 8...
January 17, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29339169/the-timing-of-p2y12-inhibitor-initiation-in-the-treatment-of-acs-does-the-evidence-exist-in-this-era
#2
REVIEW
Harsh Golwala, Deepak L Bhatt
The majority of acute coronary syndromes (ACS) are well characterized as a consequence of plaque rupture and subsequent thrombosis. Antiplatelet agents targeting inhibition of P2Y12 receptors on the platelets have shown to reduce future risk of cardiovascular events in this patient population. However, the timing of initiation of these agents, in particular, in patients managed with invasive strategy with percutaneous coronary interventions (PCI) is debatable. The data supporting pretreatment with antiplatelet agents prior to PCI in ACS patients dates to trials performed >15 years ago, wherein the time to PCI was >5 days, and henceforth, the utility of pretreatment with these agents in the contemporary era remains uncertain...
January 12, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29336246/the-role-of-colchicine-in-the-prevention-of-cerebrovascular-ischemia
#3
Georgios Tsivgoulis, Aristeidis H Katsanos, Georgios Giannopoulos, Vasiliki Panagopoulou, Dalius Jatuzis, Robin Lemnens, Spyridon Deftereos, Peter J Kelly
INTRODUCTION: Despite the proven efficacy of anti-thrombotic, lipid-lowering, anti-hypertensive therapies and lifestyle modification changes for secondary ischemic stroke prevention, the risk of recurrent stroke, coronary events and vascular death remains substantial even for patients treated with high rates of established secondary preventive medications. METHODS: In the present review, we summarize available literature data on the association between systemic inflammation and symptomatic atherosclerosis including recurrent cerebral ischemia...
January 15, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29335827/satisfactory-arterial-repair-1%C3%A2-year-after-ultrathin-strut-biodegradable-polymer-sirolimus-eluting-stent-implantation-an-angioscopic-observation
#4
Takayuki Ishihara, Masaki Awata, Osamu Iida, Masashi Fujita, Masaharu Masuda, Shin Okamoto, Kiyonori Nanto, Takashi Kanda, Takuya Tsujimura, Masaaki Uematsu, Toshiaki Mano
The ultrathin strut biodegradable polymer sirolimus-eluting stent (Orsiro, O-SES) exhibits satisfactory clinical outcomes. However, no report to date has documented the intravascular status of artery repair after O-SES implantation. We examined 5 O-SES placed in 4 patients (age 65 ± 12 years, male 75%) presenting with stable angina pectoris due to de novo lesions in native coronary arteries. Coronary angioscopy was performed immediately after percutaneous coronary intervention and 1 year later. Angioscopic images were analyzed to determine the following: (1) dominant grade of neointimal coverage (NIC) over the stent; (2) maximum yellow plaque grade; and (3) existence of thrombus...
January 15, 2018: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/29332908/optical-coherence-tomography-guidance-in-management-of-acute-coronary-syndrome-caused-by-plaque-erosion
#5
Haibo Jia, Takashi Kubo, Takashi Akasaka, Bo Yu
For several decades, most physicians have believed that acute coronary syndrome (ACS) is caused by coronary thrombosis resulting from rupture of vulnerable plaque characterized by a thin fibrous cap overlying a large necrotic core and massive inflammatory cell infiltration. However, nearly one-third of ACS cases are caused by plaque erosion characterized by intact fibrous cap, less or absent necrotic core, less inflammation, and large lumen. Because of the limitations of current imaging modalities, including angiography and intravascular ultrasound, the importance of plaque erosion as a cause of acute coronary events is less well known...
January 13, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29330042/differences-in-the-ct-findings-between-vulnerable-plaque-and-culprit-lesions-in-acute-coronary-syndrome
#6
Eun Ju Chun, Jin Hee Han, Seung Min Yoo, Hwa Yeon Lee, In Sup Song, Charles S White
BACKGROUND: The CT finding of "vulnerable plaque" is widely regarded as similar to that of a culprit lesion in an acute coronary syndrome (ACS). However, this hypothesis may not be accurate, since "vulnerable plaques" may substantially change their morphology when they rupture to cause an ACS. METHODS: We retrospectively evaluated coronary CT angiography data sets of 25 patients with ACS who had vulnerable (n = 10) or culprit plaques (n = 15). We analyzed CT features including positive remodeling (PR), low attenuation plaque (LAP), the napkin ring sign (NRS), degree of stenosis (normal, <50%, 50-99%, 100%), and myocardial hypoperfusion in the left ventricle...
January 5, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29329384/plaque-erosion-a-new-in-vivo-diagnosis-and-a-potential-major-shift-in-the-management-of-patients-with-acute-coronary-syndromes
#7
Ramon A Partida, Peter Libby, Filippo Crea, Ik-Kyung Jang
Pathology and in vivo imaging studies have identified superficial plaque erosion as a frequent and important mechanism underlying acute coronary syndromes (ACS). In contrast with plaque rupture, the pathophysiological mechanisms leading to plaque erosion remain poorly understood. The advent of intravascular imaging techniques, particularly optical coherence tomography, has aided understanding of this mode of ACS in vivo by complementing previous insights from pathology studies. Appreciation of the distinct biological and clinical mechanisms of plaque erosion points to the possibility of tailored management strategies for patients presenting with ACS...
January 9, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29327345/serum-lipoprotein-a-predicts-acute-coronary-syndromes-in-patients-with-severe-carotid-stenosis
#8
Fabio Rigamonti, Federico Carbone, Fabrizio Montecucco, Aldo Bonaventura, Luca Liberale, Fabienne Burger, Aline Roth, Maria Bertolotto, Giovanni Spinella, Bianca Pane, Domenico Palombo, Aldo Pende, Franco Dallegri, François Mach, Stefano Bertolini, Livia Pisciotta
Different cut-off values of serum lipoprotein(a) [Lp(a)] were recently identified in order to better stratify cardiovascular risk categories. Both pathophysiological and prognostic values of Lp(a) remain unclear. Here, the prognostic value of Lp(a) and its correlation with intraplaque features were assessed in patients with severe carotid artery stenosis undergoing endarterectomy (n=180). The cut-off value of 10 mg/dL for serum Lp(a) was selected to predict 24-month follow-up acute coronary syndrome (ACS). In addition, the association between serum Lp(a) and intraplaque lipids, collagen, inflammatory and vascular cells was assessed...
January 11, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29322695/bioresorbable-scaffolds-in-coronary-intervention-unmet-needs-and-evolution
#9
REVIEW
Davide Capodanno
Bioresorbable scaffolds (BRS) represent a novel paradigm in the 40-year history of interventional cardiology. Restoration of cyclic pulsatility and physiologic vasomotion, adaptive vascular remodeling, plaque regression, and removal of the trigger for late adverse events are expected BRS benefits over current metallic drug-eluting stents. However, first-generation BRS devices have significant manufacturing limitations and rely on optimal implantation technique to avoid experiencing an excess of clinical events...
January 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/29322177/high-risk-coronary-atherosclerotic-plaque-assessment-by-coronary-computed-tomography-angiography-should-we-use-it
#10
Raymond J Gibbons
No abstract text is available yet for this article.
January 10, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29322167/use-of-high-risk-coronary-atherosclerotic-plaque-detection-for-risk-stratification-of-patients-with-stable-chest-pain-a-secondary-analysis-of-the-promise-randomized-clinical-trial
#11
Maros Ferencik, Thomas Mayrhofer, Daniel O Bittner, Hamed Emami, Stefan B Puchner, Michael T Lu, Nandini M Meyersohn, Alexander V Ivanov, Elizabeth C Adami, Manesh R Patel, Daniel B Mark, James E Udelson, Kerry L Lee, Pamela S Douglas, Udo Hoffmann
Importance: Coronary computed tomographic angiography (coronary CTA) can characterize coronary artery disease, including high-risk plaque. A noninvasive method of identifying high-risk plaque before major adverse cardiovascular events (MACE) could provide practice-changing optimizations in coronary artery disease care. Objective: To determine whether high-risk plaque detected by coronary CTA was associated with incident MACE independently of significant stenosis (SS) and cardiovascular risk factors...
January 10, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29321430/new-onset-takayasu-s-arteritis-as-acute-myocardial-infarction
#12
Yusuke Ishiyama, Kazuo Eguchi, Katsuaki Yokota, Tomokazu Ikemoto, Kazuomi Kario
We herein report the case of a 25-year-old Japanese woman with left-main-trunk acute myocardial infarction (LMT-AMI). She had cardiogenic shock, so emergency percutaneous intervention was performed. Intravascular ultrasound of LMT-AMI showed that the three-layered structure of the intima, tunica media, and adventitia was not clearly visible, and the vessel was concentrically thickened; unstable plaque and calcification were not seen. AMI is rarely seen in young women, but Takayasu's arteritis is one major cause...
January 11, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29319263/simultaneous-plaque-rupture-in-two-coronary-arteries-presenting-as-acute-coronary-syndrome
#13
Satish Chirde
A 45 yrs male presented with angina. ECG showed transient CHB, T wave inversion in V3 to V6 and inferior leads. It was difficult to predict the culprit vessel based on ECG. Coronary angiography showed thrombotic lesions in LAD, LCX and OM which can potentially impact identification of culprit vessel and hence affect the management with primary PCI.
October 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29317977/stemi-due-to-big-ostial-left-main-thrombus-extending-into-aorta-challenging-situation-with-no-clear-guidelines
#14
Mohammady Shahin, Oliver Gaemperli, Patrick Siegrist, Jasmina Alibegovic
Extensive left main (LM) coronary artery thrombus is a rare and life-threatening angiographic finding with usual dramatic clinical presentation including hemodynamic instability and sudden cardiac death. The proper management of a big LM thrombus extending into aorta remains a challenging issue with no clear guidelines. In the following case report we present a 45-year-old patient with no apparent risk factors for coronary artery disease who presented with acute infero-lateral ST-elevation myocardial infarction (STEMI)...
December 2017: Cardiology Research
https://www.readbyqxmd.com/read/29317451/duration-of-diabetes-and-prediabetes-during-adulthood-and-subclinical-atherosclerosis-and-cardiac-dysfunction-in-middle-age-the-cardia-study
#15
Jared P Reis, Norrina B Allen, Michael P Bancks, J Jeffrey Carr, Cora E Lewis, Joao A Lima, Jamal S Rana, Samuel S Gidding, Pamela J Schreiner
OBJECTIVE: To determine whether the duration of diabetes and duration of prediabetes estimated during a 25-year period in early adulthood are each independently associated with coronary artery calcified plaque (CAC) and abnormalities in left ventricular structure and function later in life. RESEARCH DESIGN AND METHODS: Participants were 3,628 white and black adults aged 18-30 years without diabetes or prediabetes at baseline (1985-1986) in the Coronary Artery Risk Development in Young Adults (CARDIA) Study...
January 9, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29311033/lesion-specific-and-vessel-related-determinants-of-fractional-flow-reserve-beyond-coronary-artery-stenosis
#16
Amir Ahmadi, Jonathon Leipsic, Kristian A Øvrehus, Sara Gaur, Emilia Bagiella, Brian Ko, Damini Dey, Gina LaRocca, Jesper M Jensen, Hans Erik Bøtker, Stephan Achenbach, Bernard De Bruyne, Bjarne L Nørgaard, Jagat Narula
OBJECTIVES: The aims of the present study were: 1) to investigate the contribution of the extent of luminal stenosis and other lesion composition-related factors in predicting invasive fractional flow reserve (FFR); and 2) to explore the distribution of various combinations of morphological characteristics and the severity of stenosis among lesions demonstrating normal and abnormal FFR. BACKGROUND: In patients with stable ischemic heart disease, FFR-guided revascularization, as compared with medical therapy alone, is reported to improve outcomes...
January 2, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29310688/effect-of-eicosapentaenoic-acid-docosahexaenoic-acid-on-coronary-high-intensity-plaques-detected-with-non-contrast-t1-weighted-imaging-the-aquamarine-epa-dha-study-study-protocol-for-a-randomized-controlled-trial
#17
Kazuhiro Nakao, Teruo Noguchi, Yasuhide Asaumi, Yoshiaki Morita, Tomoaki Kanaya, Masashi Fujino, Hayato Hosoda, Shuichi Yoneda, Shoji Kawakami, Toshiyuki Nagai, Kensaku Nishihira, Takahiro Nakashima, Reon Kumasaka, Tetsuo Arakawa, Fumiyuki Otsuka, Michio Nakanishi, Yu Kataoka, Yoshio Tahara, Yoichi Goto, Haruko Yamamoto, Toshimitsu Hamasaki, Satoshi Yasuda
BACKGROUND: Despite the success of HMG-CoA reductase inhibitor (statin) therapy in reducing atherosclerotic cardiovascular events, a residual risk for cardiovascular events in patients with coronary artery disease (CAD) remains. Long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs), especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are promising anti-atherosclerosis agents that might reduce the residual CAD risk. Non-contrast T1-weighted imaging (T1WI) with cardiac magnetic resonance (CMR) less invasively identifies high-risk coronary plaques as high-intensity signals...
January 8, 2018: Trials
https://www.readbyqxmd.com/read/29308382/mutation-analysis-of-the-mitochondrial-trna-genes-in-iranian-coronary-atherosclerosis-patients
#18
Mohammad Mehdi Heidari, Mahboobe Derakhshani, Fatemeh Sedighi, Seyed Khalil Foruzan-Nia
Background: Atherosclerosis is a disease that affects large and medium size arteries in the body that underlies coronary heart disease. Several nucleotide changes in mitochondrial tRNA genes have been reported in various diseases. The purpose of the study was to identify hotspot mitochondrial tRNA mutations in atherosclerotic patients. Methods: In this case-control study, the variations of ten mitochondrial tRNA genes (about 50%) were investigated in 70 patients from October 2013 and June 2015 suffered from atherosclerosis...
October 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29306471/correlation-between-frequency-domain-optical-coherence-tomography-and-fractional-flow-reserve-in-angiographically-intermediate-coronary-lesions
#19
Francesco Burzotta, Roberto Nerla, Jonathan Hill, Lazzaro Paraggio, Antonio Maria Leone, Jonathan Byrne, Italo Porto, Giampaolo Niccoli, Cristina Aurigemma, Carlo Trani, Philip MacCarthy, Filippo Crea
BACKGROUND: The decision-making process of patients with angiographically-intermediate coronary lesions (ICL) is clinically challenging and may benefit from adjunctive invasive techniques. Fractional-flow-reserve (FFR) represents the gold standard to evaluate ICL but frequency-domain optical-coherence-tomography (OCT) is a novel, promising, high resolution coronary imaging technique, which allows physiopathologic assessment of coronary plaque. We investigated the possible relation between OCT and FFR in selected ICL patients...
February 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29305350/high-risk-coronary-plaque-on-computed-tomography-angiography-time-to-recognize-a-new-imaging-risk-factor
#20
EDITORIAL
Maros Ferencik, Udo Hoffmann
No abstract text is available yet for this article.
January 2018: Circulation. Cardiovascular Imaging
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