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Thermosensitive liposomes

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https://www.readbyqxmd.com/read/28282469/correction-photoacoustic-imaging-of-cancer-treatment-response-early-detection-of-therapeutic-effect-from-thermosensitive-liposomes
#1
Jonathan P May, Eno Hysi, Lauren A Wirtzfeld, Elijus Undzys, Shyh-Dar Li, Michael C Kolios
[This corrects the article DOI: 10.1371/journal.pone.0165345.].
2017: PloS One
https://www.readbyqxmd.com/read/28277004/fractional-laser-assisted-percutaneous-drug-delivery-via-temperature-responsive-liposomes
#2
Takahiro Fujimoto, Masayuki Ito, Shinobu Ito, Hideko Kanazawa
Liposomes are used for transdermal delivery of drugs and vaccines. Our objective was to develop temperature-responsive (TR) liposomes to achieve temperature-dependent, controlled release of an encapsulated drug, and use fractional laser irradiation to enhance transdermal permeability of these liposomes. TR-liposomes prepared using a thermosensitive polymer derived from poly-N-isopropylacrylamide, N,N-dimethylacrylamide, egg phosphatidylcholine, and dioleoylphosphatidylethanolamine, delivered fluorescein isothiocyanate-conjugated ovalbumin (OVA-FITC) as a model drug...
May 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28212859/docosahexaenoic-acid-phospholipid-differentially-modulates-the-conformation-of-g90v-and-n55k-rhodopsin-mutants-associated-with-retinitis-pigmentosa
#3
Xiaoyun Dong, María Guadalupe Herrera-Hernández, Eva Ramon, Pere Garriga
Rhodopsin is the visual photoreceptor of the retinal rod cells that mediates dim light vision and a prototypical member of the G protein-coupled receptor superfamily. The structural stability and functional performance of rhodopsin are modulated by membrane lipids. Docosahexaenoic acid has been shown to interact with native rhodopsin but no direct evidence has been established on the effect of such lipid on the stability and regeneration of rhodopsin mutants associated with retinal diseases. The stability and regeneration of two thermosensitive mutants G90V and N55K, associated with the retinal degenerative disease retinitis pigmentosa, have been analyzed in docosohexaenoic phospholipid (1,2-didocosa-hexaenoyl-sn-glycero-3-phosphocholine; DDHA-PC) liposomes...
February 16, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28159640/focused-ultrasound-triggered-release-of-tyrosine-kinase-inhibitor-from-thermosensitve-liposomes-for-treatment-of-renal-cell-carcinoma
#4
Caleb Abshire, Hakm Y Murad, Jaspreet S Arora, James Liu, Sree Harsha Mandava, Vijay T John, Damir B Khismatullin, Benjamin R Lee
This study reports, for the first time, development of tyrosine kinase inhibitor-loaded, thermosensitive liposomes (TKI/TSLs) and their efficacy for treatment of renal cell carcinoma when triggered by focused ultrasound (FUS). Uptake of these nanoparticles into renal cancer cells was visualized with confocal and fluorescent imaging of rhodamine B-loaded liposomes. The combination of TKI/TSLs and focused ultrasound was tested in an in vitro tumor model of renal cell carcinoma. According to MTT cytotoxic assay and flow cytometric analysis the combined treatment led to the least viability (23...
January 31, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28135098/therapeutic-efficacy-of-cisplatin-thermosensitive-liposomes-upon-mild-hyperthermia-in-c26-tumor-bearing-balb-c-mice
#5
Seyedeh Hoda Alavizadeh, Fatemeh Gheybi, Amin Reza Nikpoor, Ali Badiee, Shiva Golmohammadzadeh, Mahmoud Reza Jaafari
This study reports on the activity of thermosensitive liposomes (TSLs) incorporating different HSPC ratios in DPPC/MSPC/PEG2000-DSPE matrix (90/10/4) plus mild hyperthermia (HT) (42 °C). TSLs were loaded with a poorly membrane permeable anticancer drug, cisplatin, through the passive equilibration method. The addition of HSPC to the corresponding DPPC lipid matrix increased the transition temperature. In vitro data demonstrated >90% cisplatin leakage from nanosized DPPC 90-lyso-TSL (LTSL) within 10 min at 42 °C, while other TSLs bearing HSPC showed greater stability...
February 14, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28122204/to-heat-or-not-to-heat-challenges-with-clinical-translation-of-thermosensitive-liposomes
#6
REVIEW
Yannan Dou, Kullervo Hynynen, Christine Allen
Thermosensitive liposomes have been put forward as a strategy to improve upon the limited tumor drug availability associated with conventional non-thermosensitive liposomes. ThermoDox® is the first and only thermosensitive liposome formulation to reach clinical development. The initial Phase III clinical trial on ThermoDox® (i.e. HEAT trial) evaluating the combination of ThermoDox® and radiofrequency ablation (RFA) in comparison to RFA alone for treatment of inoperable hepatocellular carcinoma (HCC) failed to reach its primary endpoint in progression-free survival (PFS)...
January 22, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28106955/cypate-mediated-thermosensitive-nanoliposome-for-tumor-imaging-and-photothermal-triggered-drug-release
#7
Zhihao Han, Liwei Lv, Yi Ma, Zhaohui Wang, Yuxi Liu, Min Zhang, Siwen Li, Yueqing Gu
It is an emerging focus to explore controlled release drug delivery systems for simultaneous cancer imaging and therapy. Herein, we synthesized a photothermal sensitive multifunctional nano-liposome drug delivery system, with doxorubicin wrapped in the hydropholic layer as the therapeutical agent and cypate doped in the hydrophobic layer as the diagnostic agent. A series of in vitro and in vivo characterization demonstrated the stability of synthesized liposome, as the DL% was 9 ± 1.5 and the EE% was 82.7 ± 2...
January 20, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28042085/sequential-hifu-heating-and-nanobubble-encapsulation-provide-efficient-drug-penetration-from-stealth-and-temperature-sensitive-liposomes-in-colon-cancer
#8
Joshua VanOsdol, Kalyani Ektate, Selvarani Ramasamy, Danny Maples, Willie Collins, Jerry Malayer, Ashish Ranjan
Mild hyperthermia generated using high intensity focused ultrasound (HIFU) and microbubbles (MBs) can improve tumor drug delivery from non-thermosensitive liposomes (NTSLs) and low temperature sensitive liposomes (LTSLs). However, MB and HIFU are limited by the half-life of the contrast agent and challenges in accurate control of large volume tumor hyperthermia for longer duration (>30min.). The objectives of this study were to: 1) synthesize and characterized long-circulating echogenic nanobubble encapsulated LTSLs (ELTSLs) and NTSLs (ENTSLs), 2) evaluate in vivo drug release following short duration (~20min each) HIFU treatments administered sequentially over an hour in a large volume of mouse xenograft colon tumor, and 3) determine the impact of the HIFU/nanobubble combination on intratumoral drug distribution...
February 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28042084/inhomogeneous-crystal-grain-formation-in-dppc-dspc-based-thermosensitive-liposomes-determines-content-release-kinetics
#9
Tao Lu, Timo L M Ten Hagen
Thermosensitive liposomes (TSL) receive attention due to their rapid externally controlled drug release at transition temperature in combination with hyperthermia. This rapid release feature of TSL occurs when the liposome membrane is going through a phase change which results in numerous interfaces, at so-called crystal grain boundaries. Based on experience with TSLs, our group found that thermosensitive liposomes formulated by binary compositions of DPPC and DSPC at proper ratios are able to exhibit rapid release without incorporation of release-promoting components...
December 29, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27863656/engineering-thermosensitive-liposome-nanoparticle-hybrids-loaded-with-doxorubicin-for-heat-triggered-drug-release
#10
Zahraa Al-Ahmady, Neus Lozano, Kuo-Ching Mei, Wafa' T Al-Jamal, Kostas Kostarelos
The engineering of responsive multifunctional delivery systems that combine therapeutic and diagnostic (theranostic) capabilities holds great promise and interest. We describe the design of thermosensitive liposome-nanoparticle (NP) hybrids that can modulate drug release in response to external heating stimulus. These hybrid systems were successfully engineered by the incorporation of gold, silver, and iron oxide NPs into the lipid bilayer of lysolipid-containing thermosensitive liposomes (LTSL). Structural characterization of LTSL-NP hybrids using cryo-EM and AFM revealed the incorporation of metallic NPs into the lipid membranes without compromising doxorubicin loading and retention capability...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27788199/photoacoustic-imaging-of-cancer-treatment-response-early-detection-of-therapeutic-effect-from-thermosensitive-liposomes
#11
Jonathan P May, Eno Hysi, Lauren A Wirtzfeld, Elijus Undzys, Shyh-Dar Li, Michael C Kolios
Imaging methods capable of indicating the potential for success of an individualized treatment course, during or immediately following the treatment, could improve therapeutic outcomes. Temperature Sensitive Liposomes (TSLs) provide an effective way to deliver chemotherapeutics to a localized tumoral area heated to mild-hyperthermia (HT). The high drug levels reached in the tumor vasculature lead to increased tumor regression via the cascade of events during and immediately following treatment. For a TSL carrying doxorubicin (DOX) these include the rapid and intense exposure of endothelial cells to high drug concentrations, hemorrhage, blood coagulation and vascular shutdown...
2016: PloS One
https://www.readbyqxmd.com/read/27773752/a-stimuli-responsive-liposome-loaded-hydrogel-provides-flexible-on-demand-release-of-therapeutic-agents
#12
Hugh S O'Neill, Caroline C Herron, Conn L Hastings, Roel Deckers, Adolfo Lopez Noriega, Helena M Kelly, Wim E Hennink, Ciarán O McDonnell, Fergal J O'Brien, Eduardo Ruiz-Hernández, Garry P Duffy
Lysolipid-based thermosensitive liposomes (LTSL) embedded in a chitosan-based thermoresponsive hydrogel matrix (denoted Lipogel) represents a novel approach for the spatiotemporal release of therapeutic agents. The entrapment of drug-loaded liposomes in an injectable hydrogel permits local liposome retention, thus providing a prolonged release in target tissues. Moreover, release can be controlled through the use of a minimally invasive external hyperthermic stimulus. Temporal control of release is particularly important for complex multi-step physiological processes, such as angiogenesis, in which different signals are required at different times in order to produce a robust vasculature...
October 20, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27722604/computational-insights-into-the-destabilization-of-%C3%AE-helical-conformations-formed-by-leucine-zipper-peptides-in-response-to-temperature
#13
Xiejun Xu, Xingqing Xiao, Shouhong Xu, Honglai Liu
Recent experiments in our lab (Phys. Chem. Chem. Phys., 2016, 18, 10129-10137) suggested using leucine zipper peptides to enhance the thermosensitivity of liposomes. To understand the mechanisms of temperature-responsive control by the leucine zipper peptide in liposomes, we firstly performed quantum mechanics calculations and implicit-solvent replica exchange molecular dynamics simulations to study the thermo-stability of two leucine zipper peptides, CH3(CH2)4-CO-[VAQLEVK-VAQLESK-VSKLESK-VSSLESK] (termed the capped peptide) and A-[VAQLEVK-VAQLESK-VSKLESK-VSSLESK] (termed the ALA peptide)...
September 14, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27667179/ultrasound-triggered-drug-delivery-for-cancer-treatment-using-drug-delivery-systems-from-theoretical-considerations-to-practical-applications
#14
Tanguy Boissenot, Alexandre Bordat, Elias Fattal, Nicolas Tsapis
Ultrasound-triggered drug delivery is now becoming a mature technology with first patients enrolling in clinical trials. Having a clear overview of the field is complicated as it mixes ultrasound physics and biological effects, particle formulation, and pharmacokinetics and biodistribution. The scope of this review is to move from basics to the latest developments of combined techniques using ultrasound for triggering drug release. Generalities on ultrasound are first given to better understand the parameters on which the clinician can operate to modulate the amount of delivered energy...
November 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27622711/magnetically-actuated-protease-sensors-for-in-vivo-tumor-profiling
#15
Simone Schuerle, Jaideep S Dudani, Michael G Christiansen, Polina Anikeeva, Sangeeta N Bhatia
Targeted cancer therapies require a precise determination of the underlying biological processes driving tumorigenesis within the complex tumor microenvironment. Therefore, new diagnostic tools that capture the molecular activity at the disease site in vivo are needed to better understand tumor behavior and ultimately maximize therapeutic responses. Matrix metalloproteinases (MMPs) drive multiple aspects of tumorigenesis, and their activity can be monitored using engineered peptide substrates as protease-specific probes...
October 12, 2016: Nano Letters
https://www.readbyqxmd.com/read/27592502/a-pilot-trial-of-doxorubicin-containing-phosphatidyldiglycerol-based-thermosensitive-liposomes-in-spontaneous-feline-soft-tissue-sarcoma
#16
Katja Zimmermann, Martin Hossann, Johannes Hirschberger, Karin Troedson, Michael Peller, Moritz Schneider, Andreas Brühschwein, Andrea Meyer-Lindenberg, Gerhard Wess, Melanie Wergin, René Dörfelt, Thomas Knösel, Markus Schwaiger, Christine Baumgartner, Johanna Brandl, Sabine Schwamberger, Lars H Lindner
PURPOSE: Doxorubicin (DOX)-loaded phosphatidyldiglycerol-based thermosensitive liposomes (DPPG2-TSL-DOX) combined with local hyperthermia (HT) were evaluated in cats with locally advanced spontaneous fibrosarcomas (soft tissue sarcoma, STS). The study was designed to evaluate the safety and pharmacokinetic profile of the drug. Results from four dose-levels are reported. METHODS: Eleven client-owned cats with advanced STS were enrolled. Five cats received escalating doses of 0...
September 4, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27570563/motion-compensated-ultrasound-imaging-allows-thermometry-and-image-guided-drug-delivery-monitoring-from-echogenic-liposomes
#17
Kalyani Ektate, Ankur Kapoor, Danny Maples, Ahmet Tuysuzoglu, Joshua VanOsdol, Selvarani Ramasami, Ashish Ranjan
Ultrasound imaging is widely used both for cancer diagnosis and to assess therapeutic success, but due to its weak tissue contrast and the short half-life of commercially available contrast agents, it is currently not practical for assessing motion compensated contrast-enhanced tumor imaging, or for determining time-resolved absolute tumor temperature while simultaneously reporting on drug delivery. The objectives of this study were to: 1) develop echogenic heat sensitive liposomes (E-LTSL) and non-thermosensitive liposomes (E-NTSL) to enhance half-life of contrast agents, and 2) measure motion compensated temperature induced state changes in acoustic impedance and Laplace pressure of liposomes to monitor temperature and doxorubicin (Dox) delivery to tumors...
2016: Theranostics
https://www.readbyqxmd.com/read/27446503/investigation-of-particle-accumulation-chemosensitivity-and-thermosensitivity-for-effective-solid-tumor-therapy-using-thermosensitive-liposomes-and-hyperthermia
#18
Wouter J M Lokerse, Michiel Bolkestein, Timo L M Ten Hagen, Marion de Jong, Alexander M M Eggermont, Holger Grüll, Gerben A Koning
Doxorubicin (Dox) loaded thermosensitive liposomes (TSLs) have shown promising results for hyperthermia-induced local drug delivery to solid tumors. Typically, the tumor is heated to hyperthermic temperatures (41-42 °C), which induced intravascular drug release from TSLs within the tumor tissue leading to high local drug concentrations (1-step delivery protocol). Next to providing a trigger for drug release, hyperthermia (HT) has been shown to be cytotoxic to tumor tissue, to enhance chemosensitivity and to increase particle extravasation from the vasculature into the tumor interstitial space...
2016: Theranostics
https://www.readbyqxmd.com/read/27434152/egfr-targeted-thermosensitive-liposomes-a-novel-multifunctional-platform-for-simultaneous-tumor-targeted-and-stimulus-responsive-drug-delivery
#19
Azadeh Haeri, Sara Zalba, Timo L M Ten Hagen, Simin Dadashzadeh, Gerben A Koning
The epidermal growth factor receptor (EGFR) is a promising target for anti-cancer therapy. The aim of this study was to design thermosensitive liposomes (TSL), functionalized with anti-EGFR ligands for targeted delivery and localized triggered release of chemotherapy. For targeting, EGFR specific peptide (GE11) and Fab' fragments of cetuximab were used and the effect of ligand density on in vitro tumor targeting was investigated. Ligand conjugation did not significantly change the physicochemical characteristics of liposomes...
October 1, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27429294/thermal-and-magnetic-dual-responsive-liposomes-with-a-cell-penetrating-peptide-sirna-conjugate-for-enhanced-and-targeted-cancer-therapy
#20
Yanfang Yang, Xiangyang Xie, Xueqing Xu, Xuejun Xia, Hongliang Wang, Lin Li, Wujun Dong, Panpan Ma, Yang Yang, Yuling Liu, Xingguo Mei
Due to the absence of effective in vivo delivery systems, the employment of small interfering RNA (siRNA) in the clinic has been hindered. Here, we describe a novel siRNA targeting system that combines features of biological (cell-permeable peptides, CPPs) and physical (magnetic) siRNA targeting for use in magnetic hyperthermia-triggered release. A siRNA-CPPs conjugate (siRNA-CPPs) was loaded into thermal and magnetic dual-responsive liposomes (TML) (siRNA-CPPs/TML), and in vitro siRNA-CPPs thermosensitive release activity, targeted cellular uptake, gene silencing efficiency, in vivo targeted delivery and in vivo antitumor activity were determined...
October 1, 2016: Colloids and Surfaces. B, Biointerfaces
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