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Thermosensitive liposomes

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https://www.readbyqxmd.com/read/28721817/improvement-of-thermosensitive-liposome-stability-by-cerasome-forming-lipid-with-si-o-si-network-structure
#1
Qin Su, Ximing Pu, He Bai, Xianchun Chen, Xiaoming Liao, Zhongbing Huang, Guangfu Yin
BACKGROUND: Liposomes have been widely used in the gene transfection and the drug delivery systems due to their excellent biocompatibility and encapsulation ability, especially, the ability to deliver the gene/drug into the cells via the membrane fusion. Thermosensitive liposoems have been proven to be a precise and effective method for cancer treatment in many preclinical studies. But the imperfect crystalline arrangement between grains occurred, resulting in planar defects at the boundaries of membranes, compromising the stability of thermosensitive liposomes...
July 19, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28696100/thermosensitive-liposomal-co-delivery-of-hsa-paclitaxel-and-hsa-ellagic-acid-complexes-for-enhanced-drug-perfusion-and-efficacy-against-pancreatic-cancer
#2
Yan Wei, Yuxi Wang, Dengning Xia, Shiyan Guo, Feng Wang, Xinxin Zhang, Yong Gan
Fibrotic stroma and tumor-promoting pancreatic stellate cells (PSCs), critical characters in the pancreatic ductal adenocarcinoma (PDA) microenvironment, promote a tumor-facilitating environment that simultaneously prevents drug penetration into tumor foci and stimulates tumor growth. Nab-PTX, a human serum albumin (HSA) nanoparticle of paclitaxel (PTX), indicates enhanced matrix penetration in PDA probably due to its small size in vivo and high affinity of HSA with secreted protein acidic and rich in cysteine (SPARC), overexpressed in the PDA stroma...
July 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28654745/efficient-cancer-regression-by-a-thermosensitive-liposome-for-photoacoustic-imaging-guided-photothermal-chemo-combinatorial-therapy
#3
Yue Cao, Jingwen Yi, Xiaoguang Yang, Lei Liu, Chunlei Yu, Yanxin Huang, Luguo Sun, Yongli Bao, Yuxin Li
The capacity to specific destruction cancer cells while avoiding normal tissue is urgently desirable in cancer treatment. Herein, photothermal-trigger released system displays as photoacoustic imaging agent constructed by entrapping diketopyrrolopyrrole-based conjugated polymers and curcumin in PEG-protected thermoresponsive liposomal phospholipid bilayer. This lipid nanostructure can improve the bioavailability of hydrophobic agent for photothermal treatment with high efficiency and deliver anticancer drug curcumin to the tumor site actuated by near-infrared (NIR) irradiation...
June 27, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28652729/nir-responsive-liposomal-system-for-rapid-release-of-drugs-in-cancer-therapy
#4
Ming-Mao Chen, Yuan-Yuan Liu, Guang-Hao Su, Fei-Fei Song, Yan Liu, Qi-Qing Zhang
To design a rapid release liposomal system for cancer therapy, a NIR responsive bubble-generating thermosensitive liposome (BTSL) system combined with photothermal agent (Cypate), doxorubicin (DOX), and NH4HCO3 was developed. Cypate/DOX-BTSL exhibited a good aqueous stability, photostability, and photothermal effect. In vitro release suggested that the amounts of DOX released from BTSL were obviously higher than that of (NH4)2SO4 liposomes at 42°C. After NIR irradiation, the hyperthermic temperature induced by Cypate led to the decomposition of NH4HCO3 and the generation of a large number of CO2 bubbles, triggering a rapid release of drugs...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28648864/impact-of-plasma-protein-binding-on-cargo-release-by-thermosensitive-liposomes-probed-by-fluorescence-correlation-spectroscopy
#5
Judith J Mittag, Barbara Kneidl, Tobias Preiß, Martin Hossann, Gerhard Winter, Stefan Wuttke, Hanna Engelke, Joachim O Rädler
Thermosensitive liposomes (TSLs) whose phase-transition temperature (Tm) lies slightly above body temperature are ideal candidates for controlled drug release via local hyperthermia. Recent studies, however, have revealed disruptive shifts in the release temperature Tr in mouse plasma, which are attributed to undefined interactions with blood proteins. Here, we study the effects of four major plasma proteins - serum albumin (SA), transferrin (Tf), apolipoprotein A1 (ApoA1) and fibrinogen (Fib) - on the temperature-dependent release of fluorescein di-β-D-galactopyranoside (FDG) from TSLs...
June 22, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28584521/tranexamic-acid-encapsulating-thermosensitive-liposomes-for-site-specific-pharmaco-laser-therapy-of-port-wine-stains
#6
M Ingmar van Raath, Ruud Weijer, Gia Hung Nguyen, Bernard Choi, Anton I de Kroon, Michal Heger
Site-specific pharmaco-laser therapy (SSPLT) is a developmental stage treatment modality designed to non-invasively remove superficial vascular pathologies such as port wine stains (PWS) by combining conventional laser therapy with the prior administration of a prothrombotic and/or antifibrinolytic pharmaceutical-containing drug delivery system. For the antifibrinolytic SSPLT component, six different PEGylated thermosensitive liposomal formulations encapsulating tranexamic acid (TA), a potent antifibrinolytic lysine analogue, were characterized for drug:lipid ratio, encapsulation efficiency, size, endovesicular TA concentration (CTA), phase transition temperature (Tm), and assayed for heat-induced TA release...
August 2016: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/28540814/lyso-thermosensitive-liposomal-doxorubicin-for-treatment-of-bladder-cancer
#7
Andrew S Mikhail, Ayele H Negussie, William F Pritchard, Dieter Haemmerich, David Woods, Ivane Bakhutashvili, Juan Esparza-Trujillo, Sam J Brancato, John Karanian, Piyush K Agarwal, Bradford J Wood
PURPOSE: To evaluate lyso-thermosensitive liposomal doxorubicin (LTLD, ThermoDox(®)) in combination with loco-regional mild hyperthermia (HT) for targeted drug delivery to the bladder wall and potential treatment of bladder cancer. MATERIAL AND METHODS: Porcine in vivo studies were performed with the following groups: (i) intravenous (IV) LTLD with hyperthermia (LTLD + HT); (ii) IV doxorubicin (DOX) with hyperthermia (IV DOX + HT) and (iii) IV LTLD without hyperthermia (LTLD - HT)...
May 10, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28482173/evaluation-of-a-combination-tumor-treatment-using-thermo-triggered-liposomal-drug-delivery-and-carbon-ion-irradiation
#8
Daisuke Kokuryo, Ichio Aoki, Eiji Yuba, Kenji Kono, Sadahito Aoshima, Jeff Kershaw, Tsuneo Saga
The combination of radiotherapy with chemotherapy is one of the most promising strategies for cancer treatment. Here, a novel combination strategy utilizing carbon ion irradiation as a high-linear energy transfer (LET) radiotherapy and a thermo-triggered nanodevice is proposed, and drug accumulation in the tumor and treatment effects are evaluated using magnetic resonance imaging relaxometry and immunohistology (Ki-67, n = 15). The thermo-triggered liposomal anticancer nanodevice was administered into colon-26 tumor-grafted mice, and drug accumulation and efficacy was compared for 6 groups (n = 32) that received or did not receive the radiotherapy and thermo trigger...
April 21, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28479096/comparing-the-therapeutic-potential-of-thermosensitive-liposomes-and-hyperthermia-in-two-distinct-subtypes-of-breast-cancer
#9
Wouter J M Lokerse, Michiel Bolkestein, Simone U Dalm, Alexander M M Eggermont, Marion de Jong, Holger Grüll, Gerben A Koning
Local drug delivery of Doxorubicin (Dox) with thermosensitive liposomes (TSL) and hyperthermia (HT) has shown preclinically to achieve high local drug concentrations with good therapeutic efficacy. Currently, this is clinically studied for treatment of chest wall recurrence of breast cancer, however with various outcomes. This study examines the potency of neoadjuvant TSL HT combination therapy in two orthotopic mouse models of human breast cancer, MDA-MB-231 and T-47D, which morphologically correlate to mesenchymal and epithelial phenotypes, respectively...
July 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28458546/a-generic-89-zr-labeling-method-to-quantify-the-in-vivo-pharmacokinetics-of-liposomal-nanoparticles-with-positron-emission-tomography
#10
Nan Li, Zilin Yu, Truc Thuy Pham, Philip J Blower, Ran Yan
Liposomal nanoparticles are versatile drug delivery vehicles that show great promise in cancer therapy. In an effort to quantitatively measure their in vivo pharmacokinetics, we developed a highly efficient (89)Zr liposome-labeling method based on a rapid ligand exchange reaction between the membrane-permeable (89)Zr(8-hydroxyquinolinate)4 complex and the hydrophilic liposomal cavity-encapsulated deferoxamine (DFO). This novel (89)Zr-labeling strategy allowed us to prepare radiolabeled forms of a folic acid (FA)-decorated active targeting (89)Zr-FA-DFO-liposome, a thermosensitive (89)Zr-DFO-liposome, and a renal avid (89)Zr-PEG-DFO-liposome at room temperature with near-quantitative isolated radiochemical yields of 98%±1% (n=6), 98%±2% (n=5), and 97%±1% (n=3), respectively...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28417560/treatment-of-tumor-in-lymph-nodes-using-near-infrared-laser-light-activated-thermosensitive-liposome-encapsulated-doxorubicin-and-gold-nanorods
#11
Daisuke Matsuki, Oladipo Adewale, Sachiko Horie, Junnosuke Okajima, Atsuki Komiya, Oluwatobi Oluwafemi, Shigenao Maruyama, Shiro Mori, Tetsuya Kodama
Tumor metastasis to lymph nodes is an important contributory factor for cancer-related deaths despite recent developments in cancer therapy. In this study, we demonstrate that tumor in the proper axillary lymph node (PALN) of the mouse can be treated by the application of external laser light to trigger the unloading of doxorubicin (DOX) encapsulated in thermosensitive liposomes (TSLs) administered together with gold nanorods (GNRs). GNRs + DOX-TSLs were injected into a mouse lymph node containing cancer cells (malignant fibrous histiocytoma-like cells) and intranodal DOX release was activated using near-infrared (NIR) laser irradiation...
April 18, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28393017/photoacoustic-signal-characterization-of-cancer-treatment-response-correlation-with-changes-in-tumor-oxygenation
#12
Eno Hysi, Lauren A Wirtzfeld, Jonathan P May, Elijus Undzys, Shyh-Dar Li, Michael C Kolios
Frequency analysis of the photoacoustic radiofrequency signals and oxygen saturation estimates were used to monitor the in-vivo response of a novel, thermosensitive liposome treatment. The liposome encapsulated doxorubicin (HaT-DOX) releasing it rapidly (<20 s) when the tumor was exposed to mild hyperthermia (43 °C). Photoacoustic imaging (VevoLAZR, 750/850 nm, 40 MHz) of EMT-6 breast cancer tumors was performed 30 min pre- and post-treatment and up to 7 days post-treatment (at 2/5/24 h timepoints)...
March 2017: Photoacoustics
https://www.readbyqxmd.com/read/28377318/the-effect-of-thermosensitive-liposomal-formulations-on-loading-and-release-of-high-molecular-weight-biomolecules
#13
Xiaoyi Huang, Min Li, Riccardo Bruni, Piergiorgio Messa, Francesco Cellesi
Thermosensitive liposomes are clinically-relevant nanocarriers which have been used to deliver chemotherapeutic agents to tumors in combination with local hyperthermia. However, the encapsulation and release of macromolecular therapeutic agents (proteins, nucleic acids, bioactive polymers) is often hindered by their instability during the liposome formation as well as by the low encapsulation efficiency. The objective of this study was to investigate the influence of the thermosensitive liposomal formulation on the encapsulation and release of low and high molecular weight hydrophilic drugs, in order to identify the key parameters to control during nanocarrier design, depending on the specific drug delivery application...
April 2, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28371376/a-smart-responsive-dual-aptamers-targeted-bubble-generating-nanosystem-for-cancer-triplex-therapy-and-ultrasound-imaging
#14
Feifei Zhao, Jie Zhou, Xiangjie Su, Yuhui Wang, Xiaosa Yan, Shaona Jia, Bin Du
The absence of targeted, single treatment methods produces low therapeutic value for treating cancers. To increase the accumulation of drugs in tumors and improve the treatment effectiveness, near-infrared 808 nm photothermal responsive dual aptamers-targeted docetaxel (DTX)-containing nanoparticles is proposed. In this system, DTX and NH4 HCO3 are loaded in thermosensitive liposomes. The surface of liposomes is coated with gold nanoshells and connected with sulfydryl (SH) modified AS1411 and S2.2 aptamers...
March 30, 2017: Small
https://www.readbyqxmd.com/read/28361609/skin-cancer-symptoms-mechanistic-pathways-and-treatment-rationale-for-therapeutic-delivery
#15
Neha Goyal, Purva Thatai, Bharti Sapra
Cancer is a group of diseases categorized by abandoning escalation and multiplication of abnormal cells. Current topical treatments for skin cancer are mainly in the semisolid dosage forms of 5-fluorouracil, imiquimod, etc. Many surgical treatments are also available these days for the treatment of skin cancer, for example, photodynamic therapy, which is approved by the US FDA. The stratum corneum is the main barrier against permeation of topical formulations developed for skin cancer treatment. Liposomes, thermosensitive stealth liposomes, nanoemulsions and polymeric lipid nanoparticles have been used by several researchers to increase skin permeability...
March 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28282469/correction-photoacoustic-imaging-of-cancer-treatment-response-early-detection-of-therapeutic-effect-from-thermosensitive-liposomes
#16
Jonathan P May, Eno Hysi, Lauren A Wirtzfeld, Elijus Undzys, Shyh-Dar Li, Michael C Kolios
[This corrects the article DOI: 10.1371/journal.pone.0165345.].
2017: PloS One
https://www.readbyqxmd.com/read/28277004/fractional-laser-assisted-percutaneous-drug-delivery-via-temperature-responsive-liposomes
#17
Takahiro Fujimoto, Masayuki Ito, Shinobu Ito, Hideko Kanazawa
Liposomes are used for transdermal delivery of drugs and vaccines. Our objective was to develop temperature-responsive (TR) liposomes to achieve temperature-dependent, controlled release of an encapsulated drug, and use fractional laser irradiation to enhance transdermal permeability of these liposomes. TR-liposomes prepared using a thermosensitive polymer derived from poly-N-isopropylacrylamide, N,N-dimethylacrylamide, egg phosphatidylcholine, and dioleoylphosphatidylethanolamine, delivered fluorescein isothiocyanate-conjugated ovalbumin (OVA-FITC) as a model drug...
May 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28212859/docosahexaenoic-acid-phospholipid-differentially-modulates-the-conformation-of-g90v-and-n55k-rhodopsin-mutants-associated-with-retinitis-pigmentosa
#18
Xiaoyun Dong, María Guadalupe Herrera-Hernández, Eva Ramon, Pere Garriga
Rhodopsin is the visual photoreceptor of the retinal rod cells that mediates dim light vision and a prototypical member of the G protein-coupled receptor superfamily. The structural stability and functional performance of rhodopsin are modulated by membrane lipids. Docosahexaenoic acid has been shown to interact with native rhodopsin but no direct evidence has been established on the effect of such lipid on the stability and regeneration of rhodopsin mutants associated with retinal diseases. The stability and regeneration of two thermosensitive mutants G90V and N55K, associated with the retinal degenerative disease retinitis pigmentosa, have been analyzed in docosohexaenoic phospholipid (1,2-didocosa-hexaenoyl-sn-glycero-3-phosphocholine; DDHA-PC) liposomes...
February 16, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28159640/focused-ultrasound-triggered-release-of-tyrosine-kinase-inhibitor-from-thermosensitive-liposomes-for-treatment-of-renal-cell-carcinoma
#19
Caleb Abshire, Hakm Y Murad, Jaspreet S Arora, James Liu, Sree Harsha Mandava, Vijay T John, Damir B Khismatullin, Benjamin R Lee
This study reports, for the first time, development of tyrosine kinase inhibitor-loaded, thermosensitive liposomes (TKI/TSLs) and their efficacy for treatment of renal cell carcinoma when triggered by focused ultrasound (FUS). Uptake of these nanoparticles into renal cancer cells was visualized with confocal and fluorescent imaging of rhodamine B-loaded liposomes. The combination of TKI/TSLs and FUS was tested in an in vitro tumor model of renal cell carcinoma. According to MTT cytotoxic assay and flow cytometric analysis, the combined treatment led to the least viability (23...
February 1, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28135098/therapeutic-efficacy-of-cisplatin-thermosensitive-liposomes-upon-mild-hyperthermia-in-c26-tumor-bearing-balb-c-mice
#20
Seyedeh Hoda Alavizadeh, Fatemeh Gheybi, Amin Reza Nikpoor, Ali Badiee, Shiva Golmohammadzadeh, Mahmoud Reza Jaafari
This study reports on the activity of thermosensitive liposomes (TSLs) incorporating different HSPC ratios in DPPC/MSPC/PEG2000-DSPE matrix (90/10/4) plus mild hyperthermia (HT) (42 °C). TSLs were loaded with a poorly membrane permeable anticancer drug, cisplatin, through the passive equilibration method. The addition of HSPC to the corresponding DPPC lipid matrix increased the transition temperature. In vitro data demonstrated >90% cisplatin leakage from nanosized DPPC 90-lyso-TSL (LTSL) within 10 min at 42 °C, while other TSLs bearing HSPC showed greater stability...
February 14, 2017: Molecular Pharmaceutics
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