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Thermosensitive liposomes

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https://www.readbyqxmd.com/read/29723616/image-guided-thermosensitive-liposomes-for-focused-ultrasound-drug-delivery-using-nirf-labelled-lipids-and-topotecan-to-visualise-the-effects-of-hyperthermia-in-tumours
#1
Miguel N Centelles, Michael Wright, Po-Wah So, Maral Amrahli, Xiao Yun Xu, Justin Stebbing, Andrew D Miller, Wladyslaw Gedroyc, Maya Thanou
Image guided drug delivery using imageable thermosensitive liposomes (iTSLs) and high intensity focused ultrasound (FUS or HIFU) has attracted interest as a novel and non-invasive route to targeted delivery of anti-cancer therapeutics. FUS-induced hyperthermia is used as an externally applied "trigger" for the release of a drug cargo from within thermosensitive drug carriers. It is suggested that sub-ablative hyperthermia significantly modifies the permeability of tumour vasculature and enhances nanoparticle uptake...
April 30, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29697100/the-comparative-effect-of-wrapping-solid-gold-nanoparticles-and-hollow-gold-nanoparticles-with-doxorubicin-loaded-thermosensitive-liposomes-for-cancer-thermo-chemotherapy
#2
Yanan Li, Dongsheng He, Jiasheng Tu, Ru Wang, Chang Zu, You Chen, Wenqian Yang, Di Shi, Thomas J Webster, Yan Shen
Since conventional chemotherapy is a systemic treatment that affects the body globally and will not concentrate inside the tumor, it causes adverse side effects to patients. In this study, doxorubicin (DOX) together with solid gold nanoparticles (GNPs) or hollow gold nanoparticles (HGNPs), respectively, is loaded inside thermosensitive liposomes (GNPs&DOX-TLs and HGNPs&DOX-TLs), where the GNPs and HGNPs act as a "nanoswitch" for killing tumor cells directly by hyperthermia and triggering DOX release from TLs in the tumor quickly by near infrared laser (NIR) illumination...
April 26, 2018: Nanoscale
https://www.readbyqxmd.com/read/29673642/hyperthermia-mediated-drug-delivery-induces-biological-effects-at-the-tumor-and-molecular-levels-that-improve-cisplatin-efficacy-in-triple-negative-breast-cancer
#3
Michael Dunne, Yannan N Dou, Danielle M Drake, Tara Spence, Sávio M L Gontijo, Peter G Wells, Christine Allen
Triple negative breast cancer is an aggressive disease that accounts for at least 15% of breast cancer diagnoses, and a disproportionately high percentage of breast cancer related morbidity. Intensive research efforts are focused on the development of more efficacious treatments for this disease, for which therapeutic options remain limited. The high incidence of mutations in key DNA repair pathways in triple negative breast cancer results in increased sensitivity to DNA damaging agents, such as platinum-based chemotherapies...
April 16, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29671386/k237-modified-thermosensitive-liposome-enhanced-the-delivery-efficiency-and-cytotoxicity-of-paclitaxel-in-vitro
#4
Xudong Fu, Yuanyuan Lu, Jiaping Guo, Hui Liu, Aiping Deng, Changchun Kuang, Xiangyang Xie
This study aimed to develop novel temperature-sensitive liposomes loading paclitaxel (PTX-TSL) and evaluate them in vitro to improve the delivery efficiency and targeting of PTX. K237 peptide was conjugated to the terminal NHS of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[hydroxyl succinimidyl (polyethylene glycol)-(DSPE-PEG-NHS), and K237-modified PTX-TSL (K237-PTX-TSL) was prepared using a film dispersion method. K237-TSL encapsulation with calcein was synthesized and used to determine the cellular uptake of TSL...
April 19, 2018: Journal of Liposome Research
https://www.readbyqxmd.com/read/29651836/near-infrared-light-activated-thermosensitive-liposomes-as-efficient-agents-for-photothermal-and-antibiotic-synergistic-therapy-of-bacterial-biofilm
#5
Yu Zhao, Xiaomei Dai, Xiaosong Wei, Yunjian Yu, Xuelei Chen, Xinge Zhang, Chaoxing Li
Biofilm is closely related to chronic infections and is difficult to eradicate. Development of effective therapy strategies to control biofilm infection is still challenging. Aiming at biofilm architecture, we designed and prepared near infrared-activated thermosensitive liposomes with photothermal and antibiotic synergistic therapy capacity to eliminate P. aeruginosa biofilm. The liposomes with positive charge and small size aided to enter the biofilm microchannels and locally released antibiotics in infection site...
April 13, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29434709/effects-of-silibinin-loaded-thermosensitive-liposome-microbubble-complex-on-inhibiting-rabbit-liver-vx2-tumors-in-sub-hyperthermia-fields
#6
Lu Han, Kai Guo, Fen Gu, Yun-Fei Zhang, Ke Li, Xi-Xi Mu, Hai-Jing Liu, Xiao-Dong Zhou, Wen Luo
In the present study, the effects of silibinin-loaded thermosensitive liposome-microbubble complex (STLMC) on rabbit liver VX2 tumors in sub-hyperthermia fields were investigated using two-dimensional ultrasonography (2D US), contrast-enhanced US (CEUS), hematoxylin and eosin (H&E) staining, immunohistochemistry and ultrastructure observation. 50 rabbits with VX2 liver tumors were divided into five groups: Sub-hyperthermia microwave ablation group (SHM), STLMC injection group (STLMC), SHM ablation plus STLMC injection group (SHM + STLMC), microbubble injection group and blank control group without any treatment...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29350904/nanoplatform-assembled-from-a-cd44-targeted-prodrug-and-smart-liposomes-for-dual-targeting-of-tumor-microenvironment-and-cancer-cells
#7
Yaqi Lv, Chaoran Xu, Xiangmei Zhao, Chenshi Lin, Xin Yang, Xiaofei Xin, Li Zhang, Chao Qin, Xiaopeng Han, Lei Yang, Wei He, Lifang Yin
The tumor microenvironment (TME) plays a critical role in tumor initiation, progression, invasion, and metastasis. Therefore, a therapy that combines chemotherapeutic drugs with a TME modulator could be a promising route for cancer treatment. This paper reports a nanoplatform self-assembled from a hyaluronic acid (HA)-paclitaxel (PTX) (HA-PTX) prodrug and marimastat (MATT)-loaded thermosensitive liposomes (LTSLs) (MATT-LTSLs) for the dual targeting of the TME and cancer cells. Interestingly, the prodrug HA-PTX can self-assemble on both positively and negatively charged liposomes, forming hybrid nanoparticles (HNPs, 100 nm)...
February 27, 2018: ACS Nano
https://www.readbyqxmd.com/read/29325469/current-update-of-a-thermosensitive-liposomes-composed-of-dppc-and-brij78
#8
Laurence Ho, Mehrdad Bokharaei, Shyh-Dar Li
Thermosensitive liposomes (TSLs) have been a prominent area of study in the discipline of tumour-targeted chemotherapeutics. The representative product of TSLs is ThermoDox® (DPPC/lyso-PC/PEG-lipid), which has advanced to Phase III clinical trials. Various groups have sought to develop a new TSL to improve upon the LTSL (lyso-lipid temperature-sensitive liposomes) formulation that is used to prepare ThermoDOX® . This review focuses on the development and recent update of an innovative TSL formulation, HaT-liposomes composed of DPPC and Brij78...
June 2018: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29276824/theranostic-nanoplatform-triple-modal-imaging-guided-synergistic-cancer-therapy-based-on-liposome-conjugated-mesoporous-silica-nanoparticles
#9
Qi Sun, Qing You, Jinping Wang, Li Liu, Yidan Wang, Yilin Song, Yu Cheng, Siyu Wang, Fengping Tan, Nan Li
Mesoporous silica nanoparticles (MSNs) have long since been investigated to provide a versatile drug-delivery platform due to their multitudinous merits. Presently, gadolinium (Gd), a T1 magnetic resonance imaging (MRI) contrast agent, was doped into MSNs as a newly emerging theranostic nanocomposite, which has received much research attention. However, it is still concerned about the dispersibility and drug leakage of MSNs. Hence, in this project, we constructed an near-infrared (NIR) irradiation-triggered, triple-modal imaging-guided nanoplatform based on doxorubicin (DOX)@Gd-doped MSNs, conjugating with indocyanine green (ICG)-loaded thermosensitive liposomes (designated as DOX@GdMSNs-ICG-TSLs)...
January 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29126907/influence-of-cholesterol-inclusion-on-the-doxorubicin-release-characteristics-of-lysolipid-based-thermosensitive-liposomes
#10
Negar Sadeghi, Roel Deckers, Burcin Ozbakir, Sohail Akthar, Robbert Jan Kok, Twan Lammers, Gert Storm
Fast hyperthermia (i.e. 39-42 °C) triggered doxorubicin release from lysolipid-containing thermosensitive liposomes (LTSL) in the tumor vasculature has been demonstrated to result in considerable enhancement of bioavailable drug levels in heated tumor tissue in preclinical tumor models. However, there is also significant leakage of doxorubicin already at 37 °C in the bloodstream, making these LTSL less efficient and increasing the risk for systemic toxicity. In conventional liposomes, cholesterol is incorporated in the bilayer to increase the stability of the liposomes...
November 7, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29124936/in-vivo-computed-tomography-photoacoustic-imaging-and-nir-triggered-chemo-photothermal-combined-therapy-based-on-a-gold-nanostar-mesoporous-silica-and-thermosensitive-liposome-composited-nanoprobe
#11
Jie An, Xiao-Quan Yang, Kai Cheng, Xian-Lin Song, Lin Zhang, Cheng Li, Xiao-Shuai Zhang, Yang Xuan, Yuan-Yang Song, Bi-Yun Fang, Xiao-Lin Hou, Yuan-Di Zhao, Bo Liu
Safe multifunctional nanoplatforms that have multiple therapeutic functions integrated with imaging capabilities are highly desired for biomedical applications. In this paper, targeted chemo-photothermal synergistic therapy and photoacoustic/computed tomography imaging of tumors were achieved by one novel multifunctional nanoprobe (GMS/DOX@SLB-FA); it was composed of a gold nanostar core and a doxorubicin (DOX)-loaded mesoporous silica shell (GMS), which was coated with a folic acid (FA)-modified thermosensitively supported lipid bilayer (SLB-FA) as a gatekeeper...
December 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29118984/clinical-trial-protocol-for-tardox-a-phase-i-study-to-investigate-the-feasibility-of-targeted-release-of-lyso-thermosensitive-liposomal-doxorubicin-thermodox%C3%A2-using-focused-ultrasound-in-patients-with-liver-tumours
#12
Paul C Lyon, Lucy F Griffiths, Jenni Lee, Daniel Chung, Robert Carlisle, Feng Wu, Mark R Middleton, Fergus V Gleeson, Constantin C Coussios
Background: TARDOX is a Phase I single center study of ultrasound triggered targeted drug delivery in adult oncology patients with incurable liver tumours. This proof of concept study is designed to demonstrate the safety and feasibility of targeted drug release and enhanced delivery of doxorubicin from thermally sensitive liposomes (ThermoDox®) triggered by mild hyperthermia induced by focused ultrasound in liver tumours. A key feature of the study is the direct quantification of the doxorubicin concentration before and after ultrasound exposure from tumour biopsies, using high performance liquid chromatography (HPLC)...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/29109030/layer-by-layer-assembly-of-graphene-oxide-on-thermosensitive-liposomes-for-photo-chemotherapy
#13
Mohadeseh Hashemi, Meisam Omidi, Bharadwaj Muralidharan, Lobat Tayebi, Matthew J Herpin, Mohammad Ali Mohagheghi, Javad Mohammadi, Hugh D C Smyth, Thomas E Milner
Stimuli responsive polyelectrolyte nanoparticles have been developed for chemo-photothermal destruction of breast cancer cells. This novel system, called layer by layer Lipo-graph (LBL Lipo-graph), is composed of alternate layers of graphene oxide (GO) and graphene oxide conjugated poly (l-lysine) (GO-PLL) deposited on cationic liposomes encapsulating doxorubicin. Various concentrations of GO and GO-PLL were examined and the optimal LBL Lipo-graph was found to have a particle size of 267.9 ± 13 nm, zeta potential of +43...
January 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29032194/in-situ-mucoadhesive-thermosensitive-liposomal-gel-as-a-novel-vehicle-for-nasal-extended-delivery-of-opiorphin
#14
Paola Mura, Natascia Mennini, Cristina Nativi, Barbara Richichi
Previous studies proved the effectiveness of an intravenous PEGylated liposomal formulation of opiorphin (1mg/mL) in protecting the drug from enzymatic degradation, and improving intensity and duration of its painkilling effect. Therefore, considering the advantages of nasal administration, the aim of this work was the development of a liposomal mucoadhesive thermo-sensitive in situ gel for the extended nasal delivery of opiorphin. With this purpose, the potential of a series of combinations of different polymers (i...
January 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29018051/phase-iii-heat-study-adding-lyso-thermosensitive-liposomal-doxorubicin-to-radiofrequency-ablation-in-patients-with-unresectable-hepatocellular-carcinoma-lesions
#15
Won Young Tak, Shi-Ming Lin, Yijun Wang, Jiasheng Zheng, Aldo Vecchione, Soo Young Park, Min Hua Chen, Stephen Wong, Ruocai Xu, Cheng-Yuan Peng, Yi-You Chiou, Guan-Tarn Huang, Jianqiang Cai, Basri Johan Jeet Abdullah, June Sung Lee, Jae Young Lee, Jong-Young Choi, Julieta Gopez-Cervantes, Morris Sherman, Richard S Finn, Masao Omata, Michael O'Neal, Lukas Makris, Nicholas Borys, Ronnie Poon, Riccardo Lencioni
Purpose: Lyso-thermosensitive liposomal doxorubicin (LTLD) consists of doxorubicin contained within a heat-sensitive liposome. When heated to ≥40°C, LTLD locally releases a high concentration of doxorubicin. We aimed to determine whether adding LTLD improves the efficacy of radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) lesions with a maximum diameter ( d max ) of 3 to 7 cm. Experimental Design: The HEAT Study was a randomized, double-blind, dummy-controlled trial of RFA ± LTLD. The 701 enrolled patients had to have ≤4 unresectable HCC lesions, at least one of which had a d max of 3 to 7 cm...
January 1, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28937646/effects-of-liposomes-contained-in-thermosensitive-hydrogels-as-biomaterials-useful-in-neural-tissue-engineering
#16
Yusser Olguín, Cristian Campos, Javiera Catalán, Luís Velásquez, Fernando Osorio, Iván Montenegro, Alejandro Madrid, Cristian Acevedo
Advances in the generation of suitable thermosensitive hydrogels for the delivery of cells in neural tissue engineering demonstrate a delicate relationship between physical properties and capabilities to promote cell proliferation and differentiation. To improve the properties of these materials, it is possible to add liposomes for the controlled release of bioactive elements, which in turn can affect the physical and biological properties of the hydrogels. In the present investigation, different hydrogels based on Pluronic F127 have been formulated with the incorporation of chitosan and two types of liposomes of two different sizes...
September 22, 2017: Materials
https://www.readbyqxmd.com/read/28934281/smart-thermosensitive-liposomes-for-effective-solid-tumor-therapy-and-in-vivo-imaging
#17
Kevin Affram, Ofonime Udofot, Mandip Singh, Sunil Krishnan, Renee Reams, Jens Rosenberg, Edward Agyare
In numerous studies, liposomes have been used to deliver anticancer drugs such as doxorubicin to local heat-triggered tumor. Here, we investigate: (i) the ability of thermosensitive liposomal nanoparticle (TSLnp) as a delivery system to deliver poorly membrane-permeable anticancer drug, gemcitabine (Gem) to solid pancreatic tumor with the aid of local mild hyperthermia and, (ii) the possibility of using gadolinium (Magnevist®) loaded-TSLnps (Gd-TSLnps) to increase magnetic resonance imaging (MRI) contrast in solid tumor...
2017: PloS One
https://www.readbyqxmd.com/read/28920483/hydroxycamptothecin-liposomes-based-on-thermal-and-magnetic-dual-responsive-system-preparation-in-vitro-and-in-vivo-antitumor-activity-microdialysis-based-tumor-pharmacokinetics
#18
Hai-Mei Zhu, Jin-Hui Gu, Yi Xie, Bo Xie, Jia-Jun Ling
Due to the absence of lactone form of hydroxycamptothecin, the commercially available hydroxycamptothecin injection exhibits inefficient therapeutic effects. In this study, we constructed a novel delivery system (thermosensitive magnetic liposomes) that protects lactone form of hydroxycamptothecin from blood or water. After hydroxycamptothecin was loaded into the thermosensitive magnetic liposome (HCPT/TML), its in vitro and in vivo antitumor activity and microdialysis-based tumour pharmacokinetics were determined...
April 2018: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28843864/sustained-release-of-intravitreal-flurbiprofen-from-a-novel-drug-in-liposome-in-hydrogel-formulation
#19
K Pachis, S Blazaki, M Tzatzarakis, P Klepetsanis, E Naoumidi, M Tsilimbaris, S G Antimisiaris
A novel Flurbiprofen (FLB)-in-liposome-in-hydrogel formulation was developed, as a method to sustain the release and increase the ocular bioavailability of FLB following intravitreal injection. For this, FLB loading into liposomes was optimized and liposomes were entrapped in thermosensitive hydrogels consisted of Pluronic F-127 (P). FLB solution, liposomes, and FLB dissolved in hydrogel were also used as control formulations. Actively loaded liposomes were found to be optimal for high FLB loading and small size, while in vitro studies revealed that P concentration of 18% (w/v) was best to retain the integrity of the hydrogel-dispersed liposome, compared to a 20% concentration...
August 25, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28819458/focused-ultrasound-hyperthermia-mediated-drug-delivery-using-thermosensitive-liposomes-and-visualized-with-in-vivo-two-photon-microscopy
#20
Marc A Santos, David E Goertz, Kullervo Hynynen
The future of nanomedicines in oncology requires leveraging more than just the passive drug accumulation in tumors through the enhanced permeability and retention effect. Promising results combining mild hyperthermia (HT) with lyso-thermosensitive liposomal doxorubicin (LTSL-DOX) has led to improved drug delivery and potent antitumor effects in pre-clinical studies. The ultimate patient benefit from these treatments can only be realized when robust methods of HT can be achieved clinically. One of the most promising methods of non-invasive HT is the use of focused ultrasound (FUS) with MRI thermometry for anatomical targeting and feedback...
2017: Theranostics
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