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asthma in adults

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https://www.readbyqxmd.com/read/28637230/perceived-stress-and-its-relationship-with-chronic-conditions-and-multimorbidity-among-229-293-community-dwelling-adults-in-44-low-and-middle-income-countries
#1
Davy Vancampfort, Ai Koyanagi, Philip B Ward, Nicola Veronese, André F Carvalho, Marco Solmi, James Mugisha, Simon Rosenbaum, Marc De Hert, Brendon Stubbs
This study assessed the association of chronic conditions and multimorbidity with perceived stress among community-dwelling adults in 44 low- and middle-income countries. Data were analyzed from the World Health Survey (2002-2004) including 229,293 adults. A perceived stress score [range 0 (lowest stress) -100 (highest stress)] was computed based on two questions from the Perceived Stress Scale. Eleven chronic conditions were assessed. Multivariable linear regression analyses were conducted to explore the associations...
June 16, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28636457/notch-signaling-in-lung-diseases
#2
Jiehan Jiang, Kui Xiao, Ping Chen
NOTCH is a fundamental signaling system that regulates normal embryonic development and tissue homeostasis in adult life. NOTCH receptor is a single-pass transmembrane protein normally triggered via direct cell-to-cell contact, in which NOTCH ligands bind the extracellular domain of the receptor, inducing γ-secretase cleavage and release of intracellular domain. The intracellular domain binds to the transcriptional effector RBPJκ to activate transcription of target genes that regulate cell differentiation, patterning, and morphogenesis during embryonic development and adult life...
June 21, 2017: Experimental Lung Research
https://www.readbyqxmd.com/read/28635546/physical-activity-and-asthma-a-longitudinal-and-multi-country-study
#3
Melissa A Russell, Christer Janson, Francisco Gómez Real, Ane Johannessen, Marie Waatevik, Bryndis Benediktsdóttir, Mathias Holm, Eva Lindberg, Vivi Schlünssen, Wasif Raza, Shyamali C Dharmage, Cecilie Svanes
OBJECTIVE: To investigate the impact of physical activity on asthma in middle-aged adults, in one longitudinal analysis, and one multi-centre cross-sectional analysis. METHODS: The Respiratory Health in Northern Europe (RHINE) is a population-based postal questionnaire cohort study. Physical activity, height and weight were self-reported in Bergen, Norway, at RHINE II (1999-2001) and all centres at RHINE III (2010-2012). A longitudinal analysis of Bergen data investigated the association of baseline physical activity with follow-up asthma, incident asthma and symptoms, using logistic and zero-inflated Poisson regression (n = 1782)...
February 16, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28634102/depression-and-asthma-outcomes-in-older-adults-results-from-the-national-health-and-nutrition-examination-survey
#4
Pooja O Patel, Minal R Patel, Alan P Baptist
BACKGROUND: Older adults have high rates of asthma morbidity and mortality, as well as increased rates of depression. There are no nationally representative studies describing the association of depression on key asthma outcomes such as emergency department (ED) visits among older adults. OBJECTIVE: The objective of this study was to determine the association of depression with asthma outcomes in older adults (age ≥ 55) from the National Health and Nutrition Examination Survey (NHANES)...
June 17, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28633906/respiratory-syncytial-virus-rsv-in-adult-emergency-department-patients-do-emergency-providers-consider-rsv-as-an-admission-diagnosis-a-retrospective-observational-study-carried-out-at-massachusetts-general-hospital-boston-ma
#5
William Binder, Jill Thorsen, Pierre Borczuk
BACKGROUND: Respiratory Syncytial Virus (RSV) has been recognized for over half a century as a cause of morbidity in infants and children. Over the past 20years, data has emerged linking RSV as a cause of illness in adults resulting in 177,000 annual hospitalizations and up to 14,000 deaths among older adults. OBJECTIVE: Characterize clinical variables in a cohort of adult RSV patients. We hypothesize that emergency physicians do not routinely consider RSV in the differential diagnosis (DDx) of influenza like illness...
June 11, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28629362/long-term-exposure-to-ambient-ultrafine-particles-and-respiratory-disease-incidence-in-in-toronto-canada-a-cohort-study
#6
Scott Weichenthal, Li Bai, Marianne Hatzopoulou, Keith Van Ryswyk, Jeffrey C Kwong, Michael Jerrett, Aaron van Donkelaar, Randall V Martin, Richard T Burnett, Hong Lu, Hong Chen
BACKGROUND: Little is known about the long-term health effects of ambient ultrafine particles (<0.1 μm) (UFPs) including their association with respiratory disease incidence. In this study, we examined the relationship between long-term exposure to ambient UFPs and the incidence of lung cancer, adult-onset asthma, and chronic obstructive pulmonary disease (COPD). METHODS: Our study cohort included approximately 1.1 million adults who resided in Toronto, Canada and who were followed for disease incidence between 1996 and 2012...
June 19, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28624716/seizure-related-hospital-admissions-readmissions-and-costs-comparisons-with-asthma-and-diabetes-in-south-australia
#7
Michelle L Bellon, Christopher Barton, Nikki McCaffrey, Denise Parker, Claire Hutchinson
PURPOSE: Seizures are listed as an Ambulatory Care Sensitive Condition (ACSC), where, in some cases, hospitalisation may be avoided with appropriate preventative and early management in primary care. We examined the frequencies, trends and financial costs of first and subsequent seizure-related hospital admissions in the adult and paediatric populations, with comparisons to bronchitis/asthma and diabetes admissions in South Australia between 2012 and 2014. METHODS: De-identified hospital separation data from five major public hospitals in metropolitan South Australia were analysed to determine the number of children and adults admitted for the following Australian Refined Diagnosis Related Groups: seizure related conditions; bronchitis/asthma; and diabetes...
June 10, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28620960/prevalence-of-chronic-obstructive-pulmonary-disease-in-independent-community-dwelling-older-adults-the-fujiwara-kyo-study
#8
Masanori Yoshikawa, Yoshifumi Yamamoto, Koichi Tomoda, Yukio Fujita, Motoo Yamauchi, Takao Osa, Hiroki Uyama, Nozomi Okamoto, Norio Kurumatani, Hiroshi Kimura
AIM: As the Japanese population ages, the number of older patients with chronic obstructive pulmonary disease (COPD) is expected to increase, but the prevalence of COPD in patients aged ≥80 years remains unclear. The purpose of the present study was to determine the prevalence of COPD in independent community-dwelling older adults aged ≥80 years. METHODS: We investigated the prevalence of COPD in 2862 independent community-dwelling older adults (1504 men, 1358 women, mean age 77...
June 16, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28620467/recent-advances-in-understanding-lung-function-development
#9
REVIEW
Erik Melén, Stefano Guerra
Recent years have witnessed critical contributions to our understanding of the determinants and long-term implications of lung function development. In this article, we review studies that have contributed to advances in understanding lung function development and its critical importance for lung health into adult life. In particular, we have focused on early life determinants that include genetic factors, perinatal events, environmental exposures, lifestyle, infancy lower respiratory tract infections, and persistent asthma phenotypes...
2017: F1000Research
https://www.readbyqxmd.com/read/28619712/targeting-acetylcholine-receptor-m3-prevents-the-progression-of-airway-hyperreactivity-in-a-mouse-model-of-childhood-asthma
#10
Kruti R Patel, Yan Bai, Kenneth G Trieu, Juliana Barrios, Xingbin Ai
Asthma often progresses into adulthood from early-life episodes of adverse environmental exposures. However, how the injury to developing lungs contributes to the pathophysiology of persistent asthma remains poorly understood. In this study, we identified an age-related mechanism along the cholinergic nerve-airway smooth muscle (ASM) axis that underlies prolonged airway hyperreactivity (AHR) in mice. We showed that ASM continued to mature until ∼3 wk after birth. Coinciding with postnatal ASM maturation, there was a critical time window for the development of ASM hypercontractility after cholinergic stimulation...
June 15, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28619271/the-impact-of-motivational-interviewing-on-adherence-and-symptom-severity-in-adolescents-and-young-adults-with-chronic-illness-a-systematic-review
#11
REVIEW
Megan R Schaefer, Jan Kavookjian
OBJECTIVE: Given the negative consequences associated with non-adherence in adolescents and young adults (AYAs) with chronic illness, it is important to identify interventions to address this issue. Therefore, this review's primary objective is to evaluate the impact of motivational interviewing (MI) on adherence and symptom level/severity in AYAs with chronic illness using a modified Cochrane method. METHOD: Four databases (e.g., CINAHL, Medline, PsychINFO, and International Pharmaceutical Abstracts) were systematically reviewed...
June 12, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28616286/severe-and-uncontrolled-asthma-in-china-a-cross-sectional-survey-from-the-australasian-severe-asthma-network
#12
Gang Wang, Fang Wang, Peter G Gibson, Michael Guo, Wei-Jie Zhang, Peng Gao, Hong-Ping Zhang, Erin S Harvey, Hui Li, Jie Zhang
BACKGROUND: Severe asthma is largely unexplored in the Chinese population. Patients with asthma underwent systematic evaluation, by investigating the characteristics of uncontrolled asthma and of asthma treated with three different controller therapies. METHODS: This multi-centre, real-world study was conducted from March 2014 to September 2015. Adults with stable asthma underwent assessment of medication use, asthma control, quality of life, psychological symptoms, work productivity and activity impairment, bronchodilator response and sputum induction...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28615272/what-do-adolescents-with-asthma-really-think-about-adherence-to-inhalers-insights-from-a-qualitative-analysis-of-a-uk-online-forum
#13
Anna De Simoni, Robert Horne, Louise Fleming, Andrew Bush, Chris Griffiths
OBJECTIVE: To explore the barriers and facilitators to inhaled asthma treatment in adolescents with asthma. DESIGN: Qualitative analysis of posts about inhaler treatment in adolescents from an online forum for people with asthma. Analysis informed by the Perceptions and Practicalities Approach. PARTICIPANTS: Fifty-four forum participants (39 adolescents ≥16 years, 5 parents of adolescents, 10 adults with asthma) identified using search terms 'teenager inhaler' and 'adolescent inhaler'...
June 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28613924/spirometry-reference-equations-from-the-hispanic-community-health-study-study-of-latinos-hchs-sol
#14
Lisa LaVange, Sonia M Davis, John Hankinson, Paul Enright, Rebbecca Wilson, R Graham Barr, Thomas K Aldrich, Ravi Kalhan, Hector Lemus, Ai Ni, Lewis J Smith, Gregory A Talavera
RATIONALE: Accurate reference values for spirometry are important, as the results are used for diagnosing common chronic lung diseases such as asthma and chronic obstructive pulmonary disease, estimating physiological impairment, and predicting all-cause mortality. Reference equations have been established for Mexican Americans but not for other Hispanic/Latino backgrounds. OBJECTIVES: To develop spirometry reference equations for adult Hispanic/Latino background groups in the United States...
June 14, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28609248/using-statewide-data-on-health-care-quality-to-assess-the-effect-of-a-patient-centered-medical-home-initiative-on-quality-of-care
#15
Nathan D Shippee, Michael Finch, Douglas Wholey
Patient-centered medical homes comprise a large portion of modern health care redesign. However, most efforts have reflected rigid, limited models of transformation. In addition, evaluations of their impact on quality of care have relied on data designed for other purposes. Minnesota's Health Care Home (HCH) initiative is a statewide medical home model relying on state-run, adaptive certification and supportive data infrastructure. This longitudinal study leverages a unique statewide system of clinic-reported, patient-level quality data (2010-2013) to assess the effect of being in a HCH clinic on health care quality...
June 13, 2017: Population Health Management
https://www.readbyqxmd.com/read/28606216/comparable-reductions-in-hyperpnoea-induced-bronchoconstriction-and-markers-of-airway-inflammation-after-supplementation-with-6%C3%A2-2-and-3%C3%A2-1-g-d-of-long-chain-n-3-pufa-in-adults-with-asthma
#16
Neil C Williams, Kirsty A Hunter, Dominick E Shaw, Kim G Jackson, Graham R Sharpe, Michael A Johnson
Although high dose n-3 PUFA supplementation reduces exercise- and hyperpnoea-induced bronchoconstriction (EIB/HIB), there are concurrent issues with cost, compliance and gastrointestinal discomfort. It is thus pertinent to establish the efficacy of lower n-3 PUFA doses. Eight male adults with asthma and HIB and eight controls without asthma were randomly supplemented with two n-3 PUFA doses (6·2 g/d (3·7 g EPA and 2·5 g DHA) and 3·1 g/d (1·8 g EPA and 1·3 g DHA)) and a placebo, each for 21 d followed by 14 d washout...
June 13, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28605691/psychiatric-outcomes-associated-with-chronic-illness-in-adolescence-a-systematic-review
#17
Ann Marie Brady, Jessica Deighton, Stephen Stansfeld
Recent years have seen an increased focus on the high rates of psychiatric comorbidities in adults with chronic illness. This systematic review explored whether chronic illness in adolescents was similarly associated with poor psychiatric outcomes. The literature search identified 129 articles, only 5 of which were indicated to be at a low risk of methodological bias. Four of these articles found a strong relationship between asthma in adolescence and an increase in the prevalence of anxiety and depressive disorders, while the remaining article, which focused on diabetes mellitus, indicated similarly increased rates of psychiatric illness...
June 9, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/28605206/the-effect-of-a-holistic-self-management-plan-on-asthma-control
#18
Eirini Grammatopoulou, Emmanouil K Skordilis, Aikaterini Haniotou, Zarotis John, Spyros Athanasopoulos
The holistic self-management plan includes lifelong actions that enable patients to cope with their disease. The present study was designed to evaluate the effect of a holistic self-management plan on asthma control. A 12-month controlled study was conducted. Adult patients with mild-to-moderate asthma (n = 24) who attended the emergency asthma department were randomized to two groups: One group followed four educational sessions and three personal home sessions (n = 12), while a second group received a short manual with asthma information (n = 12)...
June 12, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28603089/specific-allergen-immunotherapy-for-the-treatment-of-allergic-asthma-a-review-of-current-evidence
#19
J Dominguez-Ortega, J Delgado, C Blanco, L Prieto, E Arroabarren, M Cimarra, A Henriquez-Santana, J Iglesias-Souto, J M Vega-Chicote, A I Tabar
Asthma is frequently associated with atopy, characterized by the production of specific immunoglobulin E in response to environmental allergens. Currently, two types of allergen immunotherapy (AIT) are used in clinical practice: subcutaneous and sublingual immunotherapy, both accepted as key components of the therapeutic repertoire for allergic rhinitis and conjunctivitis. However, their role in asthma remains controversial. The present document is aimed at providing the clinicians with a review of the evidence on the use of AIT in asthma, focusing on the most relevant aspects of its mechanism of action, its efficacy, and existing data on safety, tolerability, and cost-effectivity, both in pediatric and adult populations...
June 2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28601684/b-cells-control-maternofetal-priming-of-allergy-and-tolerance-in-a-murine-model-of-allergic-airway-inflammation
#20
Christine Happle, Adan Chari Jirmo, Almut Meyer-Bahlburg, Anika Habener, Heinz Gerd Hoymann, Christian Hennig, Jelena Skuljec, Gesine Hansen
BACKGROUND: Allergic asthma is a chronic lung disease resulting from inappropriate immune responses to environmental antigens. Early tolerance induction is an attractive approach for primary prevention of asthma. OBJECTIVE: We analysed the mechanisms of perinatal tolerance induction to allergens with particular focus on the role of B cells in preconceptional and early intrauterine immune priming. METHODS: Wild type (WT) and B cell deficient mice received ovalbumin (OVA) intranasally before mating...
June 7, 2017: Journal of Allergy and Clinical Immunology
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