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asthma in adults

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https://www.readbyqxmd.com/read/29777329/population-pharmacokinetics-of-theophylline-in-adult-chinese-patients-with-asthma-and-chronic-obstructive-pulmonary-disease
#1
Yanjiao Ma, Ling Xue, Xin Chen, Yingbo Kang, Yong Wang, Liqing Wang
Background Theophylline has a narrow therapeutic range and large interindividual variability in blood levels, so a thorough understanding of its pharmacokinetic characteristics is essential. Population pharmacokinetic (PPK) approaches could achieve it and many PPK studies of theophylline have been reported in infants. However, none was conducted in Chinese adults and none has explored the effect of CYP1A2 genotypes on the PPK characteristics of theophylline in adults. Objective To evaluate the PPK characteristics of theophylline and to assess the possible influence of covariates, including CYP1A2 genotypes, on theophylline clearance in Chinese adult patients...
May 18, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29777106/clinical-prediction-models-to-support-the-diagnosis-of-asthma-in-primary-care-a-systematic-review-protocol
#2
L Daines, S McLean, A Buelo, S Lewis, A Sheikh, H Pinnock
Substantial over-diagnosis and under-diagnosis of asthma in adults and children has recently been reported. As asthma is mostly diagnosed in non-specialist settings, a clinical prediction model (CPM) to aid the diagnosis of asthma in primary care may help improve diagnostic accuracy. We aim to systematically identify, describe, compare, and synthesise existing CPMs designed to support the diagnosis of asthma in children and adults presenting with symptoms suggestive of the disease, in primary care settings or equivalent populations...
May 18, 2018: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/29776621/relationship-between-sleep-duration-and-self-reported-health-related-quality-of-life-among-us-adults-with-or-without-major-chronic-diseases-2014
#3
Yong Liu, Anne G Wheaton, Janet B Croft, Fang Xu, Timothy J Cunningham, Kurt J Greenlund
OBJECTIVES: To assess the association between sleep duration and health-related quality of life (HRQOL) among adults with or without chronic conditions. METHODS: Using the 2014 Behavioral Risk Factor Surveillance System, we analyzed self-reported data from adult respondents aged ≥18 years with (n=277,757, unhealthy group) and without (n=172,052. healthy group) reported history of any of nine chronic conditions (coronary heart disease, stroke, cancer, chronic obstructive pulmonary disease, diabetes, asthma, arthritis, depression, chronic kidney disease)...
June 2018: Sleep Health
https://www.readbyqxmd.com/read/29771100/-people-living-with-chronic-asthma-needs-and-expectations-regarding-the-accompaniment-offered-by-belgian-health-professionals
#4
Jehan Seret, Magali Pirson, Florence Penson, Hélène Lefebvre, Dan Lecocq
INTRODUCTION: Asthma remains a major public health problem, with 300 million people affected worldwide and a low rate of adherence to treatment. CONTEXT: Few authors have considered one of the determinants of asthmatic patients' adherence to treatment : the accompaniment offered by health care professionals. AIM: To describe the expectations and needs of people living with chronic asthma regarding their accompaniment. METHODS: A descriptive qualitative approach with reasoned sampling...
March 2018: Recherche en Soins Infirmiers
https://www.readbyqxmd.com/read/29769601/urinary-polycyclic-aromatic-hydrocarbon-metabolites-and-adult-asthma-a-case-control-study
#5
Xiji Huang, Yun Zhou, Xiuqing Cui, Xiaojie Wu, Jing Yuan, Jungang Xie, Weihong Chen
Polycyclic aromatic hydrocarbons (PAHs) exposure was reported to be associated with childhood asthma. However, the quantitative relationship between PAHs exposure and adult asthma and possible inflammatory pathways are less clear. We aimed to investigate potential associations between urinary PAHs metabolites and adult asthma. We enrolled 507 adult asthma cases and 536 matched controls. The concentrations of 12 urinary PAHs metabolites and plasma cytokines of interleukin (IL)-9 and eotaxin were measured. Potential associations between urinary PAHs metabolites and adult asthma were analyzed by logistic regression...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29769485/changes-of-peak-expiratory-flow-rate-in-adult-asthmatic-patient
#6
S Nasreen, A Nessa, F Islam, A Khanam, R Sultana, R Rahman, M Hossain
Asthma is a common pulmonary disorder characterizerized by airway inflammation, airway- hyper reactivity, and reversible airflow obstruction. The classic triad of symptoms is wheezing, chronic episodic dyspnea and chronic cough. The prevalence of asthma increased steadily over the latter part of the last century, first in the developed and then in the developing world. The number of people with asthma in the world may be as high as 334 million. Asthma in Bangladesh appears to be a substantial public health problem: an estimated 11...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29769295/indoor-mould-exposure-asthma-and-rhinitis-findings-from-systematic-reviews-and-recent-longitudinal-studies
#7
REVIEW
Denis Caillaud, Benedicte Leynaert, Marion Keirsbulck, Rachel Nadif
Starting from the Institute of Medicine (IOM) and World Health Organization (WHO) reports, this review provides an overview of the literature published from 2006 to 2017 on the associations between indoor mould exposure and asthma and rhinitis separately in children and adults with a focus on longitudinal epidemiological studies.A systematic search of peer-reviewed literature was performed, including systematic reviews and meta-analyses, longitudinal, incident case-control and panel studies. 61 publications were identified reporting visible mould or mould odour or quantitative assessment of culturable fungi or mould species...
June 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29768620/association-between-chronic-diseases-and-handgrip-strength-in-older-adults-residents-of-florian%C3%A3-polis-sc-brazil
#8
Susana Cararo Confortin, Ana Lúcia Danielewicz, Danielle Ledur Antes, Lariane Mortean Ono, Eleonora d'Orsi, Aline Rodrigues Barbosa
This paper aims to verify the association between chronic diseases and handgrip strength (HS) in the older adults of Florianópolis, SC. This is a cross-sectional analysis of a longitudinal population-based study. HS was measured by dynamometer. Independent variables included 10 chronic diseases and falls. Simple and multiple linear regression analyses were performed. In the final model, in women, arthritis/rheumatism/arthrosis (β: -1.27; 95%CI: -2.55; -0.20) was associated with lower HS and bronchitis/ asthma (β: 1...
May 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29768270/associations-of-current-wheeze-and-body-mass-index-with-perennial-and-seasonal-allergic-rhinitis-in-young-adults
#9
Munehiro Matsumoto, Satoshi Konno, Hirokazu Kimura, Nozomu Takei, Hiroki Kimura, Kaoruko Shimizu, Houman Goudarzi, Masaru Suzuki, Satoshi Hashino, Masaharu Nishimura
BACKGROUND: The coexistence of asthma and allergic rhinitis (AR) and its distinct association with obesity have been reported. However, few studies have differentiated the two types of AR, i.e., perennial (PAR) and seasonal AR (SAR), with regard to their associations with asthma and obesity. The aim of this study was to evaluate the coexistence of current wheeze and two types of AR and the impact of body mass index (BMI) on these two conditions in Japanese young adults. METHODS: First-year students from Hokkaido University were enrolled into this study from 2011 to 2016...
May 16, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29764261/ragweed-sublingual-tablet-immunotherapy-part-ii-practical-considerations-and-pertinent-issues
#10
Oliver Pfaar, Peter Socrates Creticos
Sublingual allergen immunotherapy (SLIT) has been demonstrated to be both efficacious and safe for the treatment of respiratory allergies such as allergic rhinoconjunctivitis or allergic asthma. Based on the clinical documentation of SLIT ragweed tablets, they have gained marketing authorization in the USA by the US FDA in 2014 for adult patients. Following clinical data from (pivotal) multicenter Phase II and III trials as performed in the USA and Canada and real life experience after registration in 2014, SLIT ragweed tablets can be recommended as efficacious and safe treatment option with disease modifying potential when adequately indicated and performed...
May 16, 2018: Immunotherapy
https://www.readbyqxmd.com/read/29759659/the-global-development-and-clinical-efficacy-of-sublingual-tablet-immunotherapy-for-allergic-diseases
#11
REVIEW
Hendrik Nolte, Jennifer Maloney
Allergy immunotherapy (AIT) is a treatment option for respiratory allergy that is complementary to pharmacotherapy, with a distinct mechanism of action. Alternative methods to subcutaneous administration of AIT that enable patients to safely self-administer AIT is considered an unmet clinical need. The sublingual immunotherapy tablet (SLIT-tablet) is an orally disintegrating pharmaceutical formulation (oral lyophilisate) containing standardized allergens. SLIT-tablets have been developed for sublingual immunotherapy (SLIT) of cedar-pollen, grass-pollen, ragweed-pollen, tree-pollen, and house dust mite allergies...
May 12, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29758111/genetic-profiles-of-transcriptomic-clusters-of-childhood-asthma-determine-specific-severe-subtype
#12
Y-L Yeh, M-W Su, B-L Chiang, Y-H Yang, C-H Tsai, Y L Lee
BACKGROUND: Previous studies have defined transcriptomic subtypes of adult asthma using samples of induced sputum and bronchial epithelium; however, those procedures are not readily applicable in the clinic, especially for childhood asthma. OBJECTIVE: We aim to dissect the transcriptomic clusters of childhood asthma using highly variably expressed genes of peripheral blood mononuclear cells (PBMC) among patients. METHODS: Gene expression of PBMC from 133 asthmatic children and 11 healthy controls was measured with Illumina microarrays...
May 14, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29757842/asthma-action-plans-in-the-adult-population-rediscovering-an-invaluable-tool-in-today-s-health-care-domain
#13
Jack Mayeux, Krysten Lisella Arekapudi, Azita Amiri
BACKGROUND AND PURPOSE: Asthma in adults remains a leading cause of morbidity, mortality, and increased health care costs. Asthma action plans (AAPs) have demonstrated improved health outcomes in this populace; however, AAPs continue to be underused by providers. This article aims to re-emphasize the importance of AAPs for adults and refresh providers on the effectiveness and methods to use this indispensable tool. METHODS: A literature search of MEDLINE, PubMed, Google Scholar, and CINAHL was performed, and subsequent findings were reported...
May 2018: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29757585/ige-sensitization-to-inhalant-allergens-and-its-association-with-allergic-diseases-in-adults
#14
Raheleh Shokouhi Shoormasti, Mohammad Reza Fazlollahi, Anoshirvan Kazemnejad, Behnoosh Tayebi, Fatemeh Nadali, Maryam Sharif Shoushtari, Shamim Khandan Alamdari, Majid Moslemi, Masoud Movehdi, Adriano Mari, Zahra Pourpak, Mostafa Moin
Allergic sensitization to inhalant allergens could be considered as a predictor in allergic diseases. The objective of this study was to assess IgE-mediated sensitization to inhalant allergens in allergic and non-allergic adults as well as the evaluation of its association with allergic diseases. This cross-sectional study was conducted from 2013 to 2016 in 604 allergic and 102 non-allergic adults selected from blood donor volunteers in Tehran, Iran. After taking informed consent, a standard questionnaire was filled to determine asthma, allergic rhinitis and/or conjunctivitis and atopic dermatitis in participants...
April 2018: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29756989/under-diagnosis-and-over-diagnosis-of-asthma
#15
Shawn D Aaron, Louis Philippe Boulet, Helen K Reddel, Andrea Gershon
Asthma is diagnosed based on patients' respiratory symptoms of wheeze, cough, chest tightness and/or dyspnea together with physiologic evidence of variable and reversible expiratory airflow limitation. In the United States 7.6% of adults and 8.4% of children self-report a physician diagnosis of current asthma. Population-based studies in children, adults and the elderly suggest that from 20% to 70% of asthmatics in the community remain undiagnosed and hence untreated. Under-diagnosis of asthma has been found to be associated with under-reporting of respiratory symptoms by patients to their physicians as well as poor socio-economic status...
May 14, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29755730/having-concomitant-asthma-phenotypes-is-common-and-independently-relates-to-poor-lung-function-in-nhanes-2007-2012
#16
Rita Amaral, João A Fonseca, Tiago Jacinto, Ana M Pereira, Andrei Malinovschi, Christer Janson, Kjell Alving
Background: Evidence for distinct asthma phenotypes and their overlap is becoming increasingly relevant to identify personalized and targeted therapeutic strategies. In this study, we aimed to describe the overlap of five commonly reported asthma phenotypes in US adults with current asthma and assess its association with asthma outcomes. Methods: Data from the National Health and Nutrition Examination Surveys (NHANES) 2007-2012 were used (n = 30,442). Adults with current asthma were selected...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29755573/thymus-and-activation-regulated-chemokine-tarc-ccl17-and-ige-are-associated-with-elderly-asthmatics
#17
Kyung Mi Jo, Hyo Kyung Lim, Jae Woong Sull, Eugene Choi, Ji-Sook Lee, Mee Ae Cheong, Min Hwa Hong, Yoori Kim, In Sik Kim
Background: The pathogenesis of asthma, which is an allergic lung disease, is associated with a variety of allergens such as house dust mite, pollen, and mould, IgE containing serum IgE and allergen-specific-IgE, and inflammatory cytokines including thymus and activation-regulated chemokine (TARC)/CCL17. Because aging is an essential factor in the pathogenesis of asthma, we examined biomarkers related to asthmatic subjects depending on age. Results: Physiological indices such as FEV1(forced expiratory capacity in 1 s), FEV1 (% predicted), and FEV1/FVC(forced vital capacity) (%) in asthmatic subjects were lower than those in normal subjects...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29755346/a-multicenter-randomized-double-blind-placebo-controlled-study-of-the-effects-of-loki-zupa-in-patients-with-chronic-asthma
#18
Yubao Lv, Ying Wei, Muhammadjan Abduwaki, Tohti Jurat, Fengsen Li, Huaizhen Wang, Yuhua Wu, Zheng Li, Bo Liu, Hongjun Yin, Yuxue Cao, Mammat Nurahmat, Zihui Tang, Jingcheng Dong
The purpose of this study was to evaluate the efficacy and safety of Uyghur medical formula Loki zupa in patients with chronic asthma. Adult patients with chronic asthma randomly received placebo or Loki zupa as add-on to inhaled corticosteroids (ICS) maintenance treatment. Loki zupa or mimics was administered orally 10 ml per time, three times a day for 8 weeks. The primary endpoints were asthma control test (ACT) score and peak expiratory flow (PEF). The secondary endpoints were acute exacerbation rate, lung function, night waking days, and symptom-free days in the near 2 weeks, Asthma Quality of Life Questionnaire (AQLQ) score and some inflammatory cytokines in peripheral blood...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29751756/prevalence-of-asthma-among-the-adult-general-population-of-five-middle-eastern-countries-results-of-the-snapshot-program
#19
Hesham Tarraf, Omur Aydin, Dilsad Mungan, Mohammad Albader, Bassam Mahboub, Adam Doble, Aaicha Lahlou, Luqman Tariq, Fayaz Aziz, Abdelkader El Hasnaoui
BACKGROUND: Asthma is a common chronic respiratory disease leading to morbidity, mortality and impaired quality of life worldwide. Information on asthma prevalence in the Middle East is fragmented and relatively out-dated. The SNAPSHOT program was conducted to obtain updated information. METHODS: SNAPSHOT is a cross-sectional epidemiological program carried out in five Middle Eastern countries (Egypt, Turkey, Kuwait, Saudi Arabia, and the United Arab Emirates, the latter three grouped into a Gulf cluster) to collect data on asthma, allergic rhinitis, benign prostatic hyperplasia and bipolar disorder...
May 11, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29750772/the-ins-and-outs-of-an-outside-in-view-of-allergies-atopic-dermatitis-and-allergy-prevention
#20
Marcus Shaker, Robert G P Murray, Julianne A Mann
PURPOSE OF REVIEW: The skin barrier is a dynamic innate immune organ. This review summarizes the current understanding of how deficiencies associated with atopic dermatitis invite other atopic disorders of the allergic march. RECENT FINDINGS: Atopic dermatitis is characterized by skin barrier defects (such as mutations in filaggrin), intrinsic proallergic T-helper cell 2 immune dysregulation, and skin microbiome alterations. These factors promote the development of food allergy and asthma...
May 9, 2018: Current Opinion in Pediatrics
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