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Unruptured cerebral aneurysm

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https://www.readbyqxmd.com/read/28101173/particularly-interesting-cys-his-rich-protein-is-highly-expressed-in-human-intracranial-aneurysms-and-resists-aneurysmal-rupture
#1
Yu-Tao Peng, Xiang-En Shi, Zhi-Qiang Li, Xin He, Yu-Ming Sun
Particularly interesting Cys-His-rich protein (PINCH) has several biological functions in cancer development, invasion and metastasis in malignant cells, and the expression of PINCH is upregulated in several cancer types, including breast cancer, gastric adenocarcinoma and rectal cancer. However, the contribution of PINCH to human cerebral aneurysms remains largely unknown. Therefore, the significance of PINCH expression in cerebral aneurysm growth and rupture was examined in the present study. The protein expression levels of alpha-smooth muscle actin, osteopontin (OPN), matrix metalloproteinase (MMP) 9 and PINCH were evaluated using immunohistochemistry and western blot analyses...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28091826/paradigms-for-single-patient-multimodality-treatment-for-cerebral-aneurysms-single-center-eleven-year-experience
#2
Abdullah Alobaid, Erez Nossek, Katherine Wagner, Avi Setton, Amir R Dehdashti, David Langer, David Chalif
Endovascular and surgical techniques are conventional options for treating intracranial aneurysms, but criteria for selecting an optimal approach for individual patients remain variable across practitioners and institutions. While endovascular and surgical approaches are generally used alone, both modalities combined in single patients can produce efficacious outcomes. The aim of this study was to evaluate outcomes of combined, concomitant endovascular and surgical modalities in the treatment of multiple and/or complex aneurysms in single patients...
January 14, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28061486/superficial-temporal-artery-sparing-mini-pterional-approach-for-cerebral-aneurysm-surgery
#3
Jun-Young Ahn, Sung-Tae Kim, Ki-Chang Yi, Won-Hee Lee, Sung Hwa Paeng, Young-Gyun Jeong
OBJECTIVE: The purposes of this study were to introduce a superficial temporal artery (STA)-sparing mini-pterional approach for the treatment of cerebral aneurysms and review the surgical results of this approach. METHODS: Between June 2010 and December 2015, we performed the STA-sparing mini-pterional approach for 117 patients with 141 unruptured intracranial aneurysms. We analyzed demographic, radiologic, and clinical variables including age, sex, craniotomy size, aneurysm location, height of STA bifurcation, and postoperative complications...
January 1, 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28057589/microsurgical-clipping-of-unruptured-intracranial-aneurysms-a-single-surgeon-s-experience-over-sixteen-years
#4
Anil Nanda, Devi Prasad Patra, Shyamal C Bir, Tanmoy K Maiti, Piyush Kalakoti, Papireddy Bollam
INTRODUCTION: Unruptured intracranial aneurysms (UIA) have become an issue of greater significance as their detection rates have increased over the years. We present the overall experience of microsurgical clipping of unruptured aneurysms by a single surgeon over a period of more than 16 years. METHODS: The clinical and radiological data were retrospectively reviewed. Clinical outcome at follow-up was assessed by Glasgow Outcome Scale (GOS), and angiograms were reviewed for the degree of occlusion...
January 2, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28028955/unruptured-intracranial-aneurysms-surgery-still-safe-as-a-treatment-option
#5
Marta Koźba-Gosztyła, Bogdan Czapiga, Włodzimierz Jarmundowicz, Łukasz Tomiałowicz
BACKGROUND: Despite a number of studies on the treatment of unruptured intracranial aneurysms (UIA), the optimal method still remains unclear. OBJECTIVES: The aim of the study was to demonstrate that UIA clipping is a safe procedure and can be a good alternative for patients not qualified for endovascular procedures and who have refused conservative management. MATERIAL AND METHODS: Results were gathered from a sample of 104 patients with UIA treated in our facility over a 9-year period starting January 2005...
September 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28017758/hemodynamic-differences-between-ruptured-and-unruptured-cerebral-aneurysms-simultaneously-existing-in-the-same-location-two-case-reports-and-proposal-of-a-novel-parameter-oscillatory-velocity-index
#6
Takanori Sano, Fujimaro Ishida, Masanori Tsuji, Kazuhiro Furukawa, Shinichi Shimosaka, Hidenori Suzuki
BACKGROUND: Recent studies have demonstrated certain hemodynamic characteristics featuring the rupture status of cerebral aneurysms using computational fluid dynamics. These studies were conducted based on the comparison of a large number of ruptured and unruptured aneurysms. However, not only aneurysm size and location but also perianeurysm environment such as hemorrhage and intracranial pressure would affect the hemodynamic changes. Therefore, we hypothesize that a case in which ruptured and unruptured cerebral aneurysms simultaneously exist in the same location would be an ideal model to reveal hemodynamic characteristics of the rupture status...
December 22, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28017223/parent-vessel-occlusion-for-treatment-of-cerebral-aneurysms-is-there-still-an-indication-a-series-of-17-patients
#7
Nishant Ganesh Kumar, Travis R Ladner, Imad S Kahn, Scott L Zuckerman, Christopher B Baker, Marybess Skaletsky, Deborah Cushing, Matthew R Sanborn, J Mocco, Robert D Ecker
INTRODUCTION/PURPOSE: Flow diversion has allowed cerebrovascular neurosurgeons and neurointerventionalists to treat complex, large aneurysms, previously treated with trapping, bypass, and/or parent vessel sacrifice. However, a minority of aneurysms remain that cannot be treated endovascularly, and microsurgical treatment is too dangerous. However, balloon test occlusion (macro and micro), micro WADA testing, ICG, intra-angiography and intra-operative monitoring are all available to clinically test the hypothesis that vessel sacrifice is safe...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27956171/endovascular-parent-artery-occlusion-of-large-or-giant-unruptured-internal-carotid-artery-aneurysms-a-long-term-single-center-experience
#8
Kampei Shimizu, Hirotoshi Imamura, Yohei Mineharu, Hidemitsu Adachi, Chiaki Sakai, Shoichi Tani, Koichi Arimura, Mikiya Beppu, Nobuyuki Sakai
The development of stent-like devices has increased treatment options for complex internal carotid artery (ICA) aneurysms, but the optimal treatment remains unclear. The purpose of this study was to evaluate the safety and efficacy of endovascular parent-artery occlusion (PAO) for ICA aneurysms. We retrospectively reviewed 28 patients with unruptured ICA aneurysms ⩾10mm treated with PAO between April 2002 and March 2015 at our institution. Patients who developed neurologic symptoms or with venous-phase delay >2s during balloon test occlusion were not treated by PAO...
December 9, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27942770/management-of-unruptured-saccular-aneurysms-of-the-m1%C3%A2-segment-with-flow-diversion-a%C3%A2-single-centre-experience
#9
Pervinder Bhogal, Rosa Martinez, Oliver Gansladt, Hansjörg Bäzner, Hans Henkes, Marta Aguilar
PURPOSE: The optimal strategy for the treatment of M1 segment aneurysms has not yet been determined as both standard microneurosurgical and endovascular techniques can pose challenges. We sought to determine the efficacy of flow diverting stents to treat small, unruptured aneurysms of the M1 segment. METHODS: We retrospectively reviewed our database of prospectively collected information for all patients treated with flow diversion for an unruptured saccular aneurysm of the middle cerebral artery (MCA) between February 2009 and February 2016...
December 11, 2016: Clinical Neuroradiology
https://www.readbyqxmd.com/read/27913802/combined-use-of-a-pconus-and-a-solitaire-stent-report-of-two-cases
#10
Pervinder Bhogal, Marta Aguilar Pérez, Rosa Martinez Moreno, Marcin Miś, Maciej Miś, Hans Henkes
OBJECTIVE: The aim of this study was to report our initial experience of the use of the pCONus neck protection device in conjunction with the Solitaire AB stent to assist in the endovascular management of complex intracranial aneurysms with arteries arising from both the neck and the dome of the aneurysm. METHODS: Two patients with unruptured aneurysms underwent elective endovascular management of their aneurysms, one arising from the middle cerebral artery bifurcation and one from the anterior communicating artery...
December 2, 2016: Interventional Neuroradiology
https://www.readbyqxmd.com/read/27911237/size-and-location-of-ruptured-intracranial-aneurysms-consecutive-series-of-1993-hospital-admitted-patients
#11
Miikka Korja, Riku Kivisaari, Behnam Rezai Jahromi, Hanna Lehto
OBJECTIVE Large consecutive series on the size and location of ruptured intracranial aneurysms (RIAs) are limited, and therefore it has been difficult to estimate population-wide effects of size-based treatment strategies of unruptured intracranial aneurysms. The authors' aim was to define the size and location of RIAs in patients diagnosed with subarachnoid hemorrhage due to aneurysm rupture in a high-volume academic center. METHODS Consecutive patients admitted to a large nonprofit academic hospital with saccular RIAs between 1995 and 2009 were identified, and the size, location, and multiplicity of RIAs were defined and reported by patient sex...
December 2, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27903923/stent-assisted-coil-embolization-of-a-recurrent-posterior-cerebral-artery-aneurysm-following-surgical-clipping
#12
Tomonori Takeshita, Tomoaki Nagamine, Kohei Ishihara, Yasuhiko Kaku
Posterior cerebral artery (PCA) aneurysms are rare, and direct surgery of these is considered difficult. Coil embolization of PCA aneurysms is becoming popular. However, it is difficult to completely obliterate the aneurysm while preserving the flow of the parent artery in large or giant PCA aneurysms with a wide neck with this technique. We report a case of a large and wide-necked PCA aneurysm with multiple recurrences following successful surgical clipping and coil embolization.A 77-year-old man with a large unruptured right PCA (P2) aneurysm was successfully treated by surgical clipping...
November 30, 2016: Neuroradiology Journal
https://www.readbyqxmd.com/read/27895300/thsd1-thrombospondin-type-1-domain-containing-protein-1-mutation-in-the-pathogenesis-of-intracranial-aneurysm-and-subarachnoid-hemorrhage
#13
Teresa Santiago-Sim, Xiaoqian Fang, Morgan L Hennessy, Stephen V Nalbach, Steven R DePalma, Ming Sum Lee, Steven C Greenway, Barbara McDonough, Georgene W Hergenroeder, Kyla J Patek, Sarah M Colosimo, Krista J Qualmann, John P Hagan, Dianna M Milewicz, Calum A MacRae, Susan M Dymecki, Christine E Seidman, J G Seidman, Dong H Kim
BACKGROUND AND PURPOSE: A ruptured intracranial aneurysm (IA) is the leading cause of a subarachnoid hemorrhage. This study seeks to define a specific gene whose mutation leads to disease. METHODS: More than 500 IA probands and 100 affected families were enrolled and clinically characterized. Whole exome sequencing was performed on a large family, revealing a segregating THSD1 (thrombospondin type 1 domain containing protein 1) mutation. THSD1 was sequenced in other probands and controls...
December 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27890748/small-unruptured-intracranial-aneurysm-%C3%A2-5-mm-associated-with-epilepsy-report-of-2-cases-and-literature-review
#14
Fuxin Lin, Hui Wan, Dezhi Kang, Yuanxiang Lin
BACKGROUND: Owing to the continuing improvements in imaging technology, an increasing number of epileptogenic small (≤5 mm) unruptured intracranial aneurysms (sUIAs) are being diagnosed. However, these sUIAs have not been systematically described and reviewed until now. CASE DESCRIPTION AND LITERATURE REVIEW: We report 2 patients with sUIAs who initially presented with complex partial seizures. Scalp electroencephalography identified the seizure activity as arising from the mesial temporal/frontal areas, but conventional magnetic resonance imaging (MRI) was normal in both patients...
November 24, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27888225/use-of-the-pipeline-embolization-device-for-recurrent-and-residual-cerebral-aneurysms-a-safety-and-efficacy-analysis-with-short-term-follow-up
#15
Anna Luisa Kühn, Katyucia de Macedo Rodrigues, J Diego Lozano, David E Rex, Francesco Massari, Takamitsu Tamura, Mary Howk, Christopher Brooks, Jenna L'Heureux, Matthew J Gounis, Ajay K Wakhloo, Ajit S Puri
OBJECTIVE: Evaluation of the safety and efficacy of the Pipeline embolization device (PED) when used as second-line treatment for recurrent or residual, pretreated ruptured and unruptured intracranial aneurysms (IAs). METHODS: Retrospective review of our database to include all patients who were treated with a PED for recurrent or residual IAs following surgical clipping or coiling. We evaluated neurological outcome and angiograms at discharge, 6- and 12-months' follow-up and assessed intimal hyperplasia at follow-up...
November 25, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/27880805/feasibility-of-quantification-of-intracranial-aneurysm-pulsation-with-4d-cta-with-manual-and-computer-aided-post-processing
#16
Till Illies, Dennis Saering, Manabu Kinoshita, Toshiyuki Fujinaka, Maxim Bester, Jens Fiehler, Noriyuki Tomiyama, Yoshiyuki Watanabe
BACKGROUND AND PURPOSE: The analysis of the pulsation of unruptured intracranial aneurysms might improve the assessment of their stability and risk of rupture. Pulsations can easily be concealed due to the small movements of the aneurysm wall, making post-processing highly demanding. We hypothesized that the quantification of aneurysm pulsation is technically feasible and can be improved by computer-aided post-processing. MATERIALS AND METHODS: Images of 14 cerebral aneurysms were acquired with an ECG-triggered 4D CTA...
2016: PloS One
https://www.readbyqxmd.com/read/27858574/quantitative-anatomical-analysis-and-clinical-experience-with-mini-pterional-and-mini-orbitozygomatic-approaches-for-intracranial-aneurysm-surgery
#17
Kaan Yagmurlu, Sam Safavi-Abbasi, Evgenii Belykh, M Yashar S Kalani, Peter Nakaji, Albert L Rhoton, Robert F Spetzler, Mark C Preul
OBJECTIVE The aim of this investigation was to modify the mini-pterional and mini-orbitozygomatic (mini-OZ) approaches in order to reduce the amount of tissue traumatization caused and to compare the use of the 2 approaches in the removal of circle of Willis aneurysms based on the authors' clinical experience and quantitative analysis. METHODS Three formalin-fixed adult cadaveric heads injected with colored silicone were examined. Surgical freedom and angle of attack of the mini-pterional and mini-OZ approaches were measured at 9 anatomical points, and the measurements were compared...
November 18, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27847767/the-benefits-of-navien%C3%A2-intracranial-support-catheter-for-endovascular-treatment
#18
Siwoo Lee, Tae-Sik Gong, Yong-Woo Lee, Hyo-Joon Kim, Chang-Young Kweon
OBJECTIVE: Endovascular treatment is one of the most important treatments along with open craniotomy for cerebrovascular surgery. The successful treatment of endovascular disease relies on appropriate instruments and the surgeon's skill. Endovascular treatment needs to provide safe and stable access to the catheter cavity. Additionally, it is important to maintain a round shape without changing to an oval shape. The catheter for endovascular treatment has to be flexible and accommodate at least 0...
September 2016: Journal of Cerebrovascular and Endovascular Neurosurgery
https://www.readbyqxmd.com/read/27847568/intradural-procedural-time-to-assess-technical-difficulty-of-superciliary-keyhole-and-pterional-approaches-for-unruptured-middle-cerebral-artery-aneurysms
#19
Yeon-Ju Choi, Wonsoo Son, Ki-Su Park, Jaechan Park
OBJECTIVE: This study used the intradural procedural time to assess the overall technical difficulty involved in surgically clipping an unruptured middle cerebral artery (MCA) aneurysm via a pterional or superciliary approach. The clinical and radiological variables affecting the intradural procedural time were investigated, and the intradural procedural time compared between a superciliary keyhole approach and a pterional approach. METHODS: During a 5.5-year period, patients with a single MCA aneurysm were enrolled in this retrospective study...
November 2016: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/27836403/surgical-treatment-of-unruptured-middle-cerebral-artery-aneurysms-complication-avoidance
#20
EDITORIAL
Dale Ding
No abstract text is available yet for this article.
November 6, 2016: Clinical Neurology and Neurosurgery
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