keyword
https://read.qxmd.com/read/38479927/metformin-use-is-associated-with-reduced-mortality-risk-in-diabetic-patients-with-parkinson-s-disease
#21
JOURNAL ARTICLE
Gianni Pezzoli, Emanuele Cereda, Daniela Calandrella, Michela Barichella, Salvatore Bonvegna, Ioannis U Isaias
INTRODUCTION: Parkinson's disease (PD) and type-2 diabetes (T2D) arguably share pathophysiologic mechanisms, resulting in a more severe phenotype and progression and diabetes is currently considered a risk factor of PD. Besides, research suggests antidiabetic therapies as potential disease-modifying strategies. The main aim was to assess the impact of a metformin-inclusive antidiabetic treatment on patient all-cause mortality. METHODS: A nested case-control prospective study including newly diagnosed PD patients reporting the onset of T2D within ±2 years from the onset of PD (n = 159) and matched (1:5; gender, year of PD onset and age at PD onset) non-diabetic cases (n = 795) followed until death or censoring...
April 2024: Clinical Nutrition ESPEN
https://read.qxmd.com/read/38476917/modulation-of-secretory-factors-by-lipofundin-contributes-to-its-anti%C3%A2-neuroinflammatory-effects
#22
JOURNAL ARTICLE
Ming-Shan Chen, Chia-Lin Hu, Shin-Kuang Jiang, Zhi-Yong Chong, Jui-Chieh Chen
As the global population ages, the prevalence of neuroinflammatory diseases such as Alzheimer's disease, Parkinson's disease and stroke continues to increase. Therefore, it is necessary to develop preventive and therapeutic methods against neuroinflammatory diseases. Lipofundin is a lipid emulsion commonly used in clinical anesthetic solvents and nutritional supplements. Lipid emulsions have been shown to possess anti-inflammatory properties. However, the potential beneficial effect of lipofundin against neuroinflammation requires elucidation...
April 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38474875/supplementing-ryegrass-ameliorates-commercial-diet-induced-gut-microbial-dysbiosis-associated-spleen-dysfunctions-by-gut-microbiota-spleen-axis
#23
JOURNAL ARTICLE
Qasim Ali, Sen Ma, Boshuai Liu, Jiakuan Niu, Mengqi Liu, Ahsan Mustafa, Defeng Li, Zhichang Wang, Hao Sun, Yalei Cui, Yinghua Shi
The type and composition of food strongly affect the variation and enrichment of the gut microbiota. The gut-microbiota-spleen axis has been developed, incorporating the spleen's function and maturation. However, how short-chain fatty-acid-producing gut microbiota can be considered to recover spleen function, particularly in spleens damaged by changed gut microbiota, is unknown in geese. Therefore, the gut microbial composition of the caecal chyme of geese was assessed by 16S rRNA microbial genes, and a Tax4Fun analysis identified the enrichment of KEGG orthologues involved in lipopolysaccharide production...
March 5, 2024: Nutrients
https://read.qxmd.com/read/38474781/high-density-lipoprotein-metabolism-and-function-in-cardiovascular-diseases-what-about-aging-and-diet-effects
#24
REVIEW
Mojgan Morvaridzadeh, Nada Zoubdane, Javad Heshmati, Mehdi Alami, Hicham Berrougui, Abdelouahed Khalil
Cardiovascular diseases (CVDs) have become the leading global cause of mortality, prompting a heightened focus on identifying precise indicators for their assessment and treatment. In this perspective, the plasma levels of HDL have emerged as a pivotal focus, given the demonstrable correlation between plasma levels and cardiovascular events, rendering them a noteworthy biomarker. However, it is crucial to acknowledge that HDLs, while intricate, are not presently a direct therapeutic target, necessitating a more nuanced understanding of their dynamic remodeling throughout their life cycle...
February 26, 2024: Nutrients
https://read.qxmd.com/read/38474770/cm1-a-chrysin-derivative-protects-from-endotoxin-induced-lethal-shock-by-regulating-the-excessive-activation-of-inflammatory-responses
#25
JOURNAL ARTICLE
Jae-Hyung Lee, Young-Bok Ko, Yong-Min Choi, Jinju Kim, Hwan-Doo Cho, Hyeonil Choi, Ha-Yeon Song, Jeong-Moo Han, Guang-Ho Cha, Young-Ha Lee, Jin-Man Kim, Woo-Sik Kim, Eui-Baek Byun, Jae-Min Yuk
Sepsis, a leading cause of death worldwide, is a harmful inflammatory condition that is primarily caused by an endotoxin released by Gram-negative bacteria. Effective targeted therapeutic strategies for sepsis are lacking. In this study, using an in vitro and in vivo mouse model, we demonstrated that CM1, a derivative of the natural polyphenol chrysin, exerts an anti-inflammatory effect by inducing the expression of the ubiquitin-editing protein TNFAIP3 and the NAD-dependent deacetylase sirtuin 1 (SIRT1). Interestingly, CM1 attenuated the Toll-like receptor 4 (TLR4)-induced production of inflammatory cytokines by inhibiting the extracellular-signal-regulated kinase (ERK)/MAPK and nuclear factor kappa B (NF-κB) signalling pathways...
February 25, 2024: Nutrients
https://read.qxmd.com/read/38474755/ethanolic-extract-of-propolis-and-cape-as-cardioprotective-agents-against-lps-and-ifn-%C3%AE-stressed-cardiovascular-injury
#26
JOURNAL ARTICLE
Anna Kurek-Górecka, Małgorzata Kłósek, Grażyna Pietsz, Radosław Balwierz, Paweł Olczyk, Zenon P Czuba
The inflammatory process is triggered by several factors such as toxins, pathogens, and damaged cells, promoting inflammation in various systems, including the cardiovascular system, leading to heart failure. The link between periodontitis as a chronic inflammatory disease and cardiovascular disease is confirmed. Propolis and its major component, caffeic acid phenethyl ester (CAPE), exhibit protective mechanisms and anti-inflammatory effects on the cardiovascular system. The objective of the conducted study was to assess the anti-inflammatory effects of the Polish ethanolic extract of propolis (EEP) and its major component-CAPE-in interferon-alpha (IFN-α), lipopolysaccharide (LPS), LPS + IFN-α-induced human gingival fibroblasts (HGF-1)...
February 23, 2024: Nutrients
https://read.qxmd.com/read/38474727/in-vitro-lactic-acid-bacteria-anti-hepatitis-b-virus-hbv-effect-and-modulation-of-the-intestinal-microbiota-in-fecal-cultures-from-hbv-associated-hepatocellular-carcinoma-patients
#27
JOURNAL ARTICLE
Juan Yang, He Gao, Tiantian Zhang, Yong Fan, Yuwei Wu, Xinyu Zhao, Ying Li, Lei Wu, Hui Zhao, Lingshuang Yang, Haojie Zhong, Longyan Li, Xinqiang Xie, Qingping Wu
Hepatocellular carcinoma (HCC), being ranked as the top fifth most prevalent cancer globally, poses a significant health challenge, with a considerable mortality rate. Hepatitis B virus (HBV) infection stands as the primary factor contributing to HCC, presenting substantial challenges in its treatment. This study aimed to identify lactic acid bacteria (LAB) with anti-HBV properties and evaluate their impact on the intestinal flora in HBV-associated HCC. Initially, two LAB strains, Levilactobacillus brevis SR52-2 ( L...
February 22, 2024: Nutrients
https://read.qxmd.com/read/38474557/novel-4-chromanone-derived-compounds-as-plant-immunity-inducers-against-cmv-disease-in-passiflora-spp-passion-fruit
#28
JOURNAL ARTICLE
Tianli Wu, Lu Yu, Lingling Xiao, Tao Wang, Pei Li, Bo Mu
This study involved the design and synthesis of a series of novel 4-chromanone-derived compounds. Their in vivo anti-cucumber mosaic virus (CMV) activity in field trials against CMV disease in Passiflora spp. was then assessed. Bioassay results demonstrated that compounds 7c and 7g exhibited remarkable curative effects and protection against CMV, with inhibition rates of 57.69% and 51.73% and 56.13% and 52.39%, respectively, surpassing those of dufulin and comparable to ningnanmycin. Field trials results indicated that compound 7c displayed significant efficacy against CMV disease in Passiflora spp...
February 28, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38472859/preparation-structural-identification-and-screening-of-egg-derived-peptides-with-facilitating-alcohol-metabolism-activity
#29
JOURNAL ARTICLE
Yali Tan, Yulin Wang, Yuan Wan, Yu Liang, Qiaocui Liu, Mengya Wei, Tao Hou
The aim of this study was to obtain egg-derived peptides with facilitating alcohol metabolism (EPs) by enzymolysis, to identify their structures, and screen small polypeptides with higher activity by molecular docking. The optimum conditions for preparing EPs with facilitating alcohol metabolism were obtained by a single factor experiment, adding 2% Protamex and performing enzymolysis for 3 h with a liquid-material ratio of 35:1. The dose-response relationship experiment showed that 800 mg/kg·bw EPs played a better role in facilitating alcohol metabolism...
February 28, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38472774/germination-a-powerful-way-to-improve-the-nutritional-functional-and-molecular-properties-of-white-and-red-colored-sorghum-grains
#30
JOURNAL ARTICLE
Cagla Kayisoglu, Ebrar Altikardes, Nihal Guzel, Secil Uzel
This study explored the effects of the germination of red and white sorghum grains ( Sorghum bicolor [Moench (L.)]) for up to seven days on various properties of the grain. Germination enriched sorghum's nutritional and sensory qualities while mitigating existing anti-nutritional factors. The study employed Fourier-transformed infrared spectroscopy (FT-IR) and scanning electron microscopy techniques to support its findings. Germination increased protein and lipid content but decreased starch content. White sorghum grains showed elevated calcium and magnesium but decreased iron, potassium, and zinc...
February 22, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38472768/a-comprehensive-study-from-cradle-to-grave-on-the-environmental-profile-of-malted-legumes
#31
JOURNAL ARTICLE
Mauro Moresi, Alessio Cimini
Three representative pulses from the Latium region of Italy (namely, Solco Dritto chickpeas, SDC, Gradoli Purgatory beans, GPB, and Onano lentils, OL) underwent malting to reduce their anti-nutrient content, such as phytic acid and flatulence-inducing oligosaccharides. This initiative targets the current low per capita consumption of pulses. Employing Life Cycle Analysis, their environmental impact was assessed, revealing an overall carbon footprint of 2.8 or 3.0 kg CO2e per kg of malted (M) and decorticated (D) SDCs or GPBs and OLs, respectively...
February 21, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38472764/development-of-a-green-quick-and-efficient-method-based-on-ultrasound-assisted-extraction-followed-by-hplc-dad-for-the-analysis-of-bioactive-glycoalkaloids-in-potato-peel-waste
#32
JOURNAL ARTICLE
Isabel Martínez-García, Carlos Gaona-Scheytt, Sonia Morante-Zarcero, Isabel Sierra
α-Solanine and α-chaconine are the two most predominant glycoalkaloids (GAs) present in potato. Potato peel contains a high concentration of GAs, which are especially interesting for application in the pharmaceutical industry due to their different beneficial properties (such as anticarcinogenic, anti-inflammatory, antiallergic, antipyretic, antiviral, fungicide, and antibiotic activities, among others); so, potato peel waste can be valorized by extracting these biologically active compounds. For this, a green, quick, and efficient miniaturized analytical approach based on ultrasound-assisted extraction (UAE) combined with HPLC-DAD was developed to quantify α-solanine and α-chaconine in potato peel...
February 21, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38468525/unveiling-the-compositional-analysis-of-green-coffee-beans-with-and-without-silver-skin
#33
JOURNAL ARTICLE
Shraddha Tripathi, Neha Mishra, Ritika Malviya, Arshi Ansari, Simran Shrimali, Neetu Mishra
BACKGROUND: Green Coffee Bean (GCB) is covered with silver skin that is shed as a by-product of the roasting process. For the first time, a comparative study was conducted to differentiate the compositional analysis of green coffee beans with silver skin and without silver skin. OBJECTIVE: The study aims comparatively assessing nutritional, anti-nutritional and fatty acids composition of green coffee beans with silver skin and without silver skin. The present study is also intended to find out various organic compounds of green coffee beans...
March 11, 2024: Recent Adv Food Nutr Agric
https://read.qxmd.com/read/38465786/exploring-the-impact-of-diet-and-nutrition-on-vitiligo-a-systematic-review-of-dietary-factors-and-nutritional-interventions
#34
REVIEW
Zeenat Hadi, Ravneet Kaur, Zahra Parekh, Sukul Khanna, Ahmed Bazil Bin Khalil, Haleema Qayyum Abbasi, Faiza Ashfaque, Dhruvi Shah, Vikaskumar Jitendrakumar Patel, Md Al Hasibuzzaman
BACKGROUND: Vitiligo, an autoimmune skin disorder linked to hormonal and genetic factors, results in reduced pigmentation due to a gradual decline in melanocyte activity. This systematic review delves into the role of dietary intervention and nutrition in managing vitiligo. METHODS: A comprehensive search on PubMed, Google Scholar, and European PMC identified 214 studies, with 14 meeting inclusion criteria post-screening. The selected studies primarily explored the impact of dietary supplements on disease activity...
March 11, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38464590/dietary-supplementation-of-astragalus-membranaceus-extract-affects-growth-performance-antioxidant-capacity-immune-response-and-energy-metabolism-of-largemouth-bass-micropterus-salmoides
#35
JOURNAL ARTICLE
Xuanshu He, Anqi Chen, Zhihong Liao, Jian Zhong, Anda Cheng, Xinghua Xue, Fuyuan Li, Mengdie Chen, Rong Yao, Wei Zhao, Jin Niu
The present study investigated the effects of Astragalus membranaceus extract (AME) on growth performance, immune response, and energy metabolism of juvenile largemouth bass ( Micropterus salmoides ). Seven diets containing 0%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, and 0.6% AME (Con, AME0.1, AME0.2, AME0.3, AME0.4, AME0.5, and AME0.6 groups) were formulated and fed to M. salmoides for 8 weeks. Final body weight (FBW), feed intake (FI), weight gain (WG), and specific growth rate (SGR) were all significantly higher in AME0...
2024: Aquaculture Nutrition
https://read.qxmd.com/read/38462971/natural-compounds-for-oxidative-stress-and-neuroprotection-in-schizophrenia-composition-mechanisms-and-therapeutic-potential
#36
REVIEW
Anam N Khan, Rahul D Jawarkar, Magdi E A Zaki, Aamal A Al Mutairi
OBJECTIVE: An imbalance between the generation of reactive oxygen species (ROS) and the body's antioxidant defense mechanisms is believed to be a critical factor in the development of schizophrenia (SCZ) like neurological illnesses. Understanding the roles of ROS in the development of SCZ and the potential activity of natural antioxidants against SCZ could lead to more effective therapeutic options for the prevention and treatment of the illness. METHODS: SCZ is a mental disorder characterised by progressive impairments in working memory, attention, and executive functioning...
March 11, 2024: Nutritional Neuroscience
https://read.qxmd.com/read/38457835/using-combination-of-albumin-to-fibrinogen-ratio-and-prognostic-nutritional-index-model-for-predicting-disease-activity-in-patients-with-systemic-lupus-erythematosus
#37
JOURNAL ARTICLE
Hongshuai Zhao, Zikun Huang, Shiqian Wang, Peng Fu, Biqi Fu, Yang Guo, Junming Li, Qing Luo
Background: Systemic lupus erythematosus (SLE) is chronic autoimmune disease with multiple organ damage and is associated with poor prognosis and high mortality. Identification of universal biomarkers to predict SLE activity is challenging due to the heterogeneity of the disease. This study aimed to identify the indicators that are sensitive and specific to predict activity of SLE. Methods: We retrospectively analyzed 108 patients with SLE. Patients were categorized into SLE with activity and without activity groups on the basis of SLE disease activity index...
March 8, 2024: Lupus
https://read.qxmd.com/read/38455223/therapeutic-potential-of-mangiferin-in-cancer-unveiling-regulatory-pathways-mechanisms-of-action-and-bioavailability-enhancements-an-updated-review
#38
REVIEW
Humaira Iqbal, Muhammad Inam-Ur-Raheem, Seemal Munir, Roshina Rabail, Sadia Kafeel, Arashi Shahid, Amin Mousavi Khaneghah, Rana Muhammad Aadil
Mangiferin (MGF) is a phenolic compound, which is a major source of MGF is the mango tree. MGF possesses some antioxidant, anti-inflammatory, and cytoprotective properties, enabling it to play its role against various diseases such as diabetes, obesity, lung injuries, and cancer. The word "Cancer" depicts an uncontrolled and abnormal growth of cells. This review paper reveals MGF's therapeutic, curative and protective potential impact against lung, liver, ovarian, prostate, breast, stomach, and oral cancers...
March 2024: Food Science & Nutrition
https://read.qxmd.com/read/38455162/co-treatment-with-the-seed-of-carthamus-tinctorius-l-and-the-aerial-part-of-taraxacum-coreanum-synergistically-suppresses-a%C3%AE-25-35-induced-neurotoxicity-by-altering-app-processing
#39
JOURNAL ARTICLE
Mei Tong He, Ji Hyun Kim, Eun Ju Cho
Accumulation of β-amyloid peptide (Aβ) induces neurotoxicity, which is the primary risk factor in the pathogenesis of Alzheimer's disease (AD). The cleavage of amyloid precursor protein (APP) by the β- (BACE) and γ- (PS1, PS2) secretases is a critical step in the amyloidogenic pathway. The induction of neuronal apoptosis by Aβ involves increased expression of B-cell lymphoma protein 2 (Bcl-2)-associated X (Bax) and decreased Bcl-2 expression. The seed of Carthamus tinctorius L...
March 2024: Food Science & Nutrition
https://read.qxmd.com/read/38455158/effect-of-allium-spices-garlic-and-onion-on-the-bioaccessibility-of-iron-from-moringa-oleifera-leaves
#40
JOURNAL ARTICLE
Saliou Mawouma, Florence Doudou Walko, Jude Mbyeya, Souaibou Hamidou Yaya, Emmanuel Awoudamkine, Carl Moses Mbofung Funtong
The aim of this study was to investigate the effect of garlic and onion, two Allium spices rich in sulfur compounds, on the bioaccessibility of iron from Moringa oleifera leaves. We first quantified anti-nutritional factors in various cooked mixtures of Moringa oleifera leaves and spices, with increasing level of incorporation of garlic or onion. We then assessed the iron bioaccessibility of the various mixtures using a simulated in vitro digestion method. Finally, we studied the speciation of bioaccessible iron...
March 2024: Food Science & Nutrition
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