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Anti-nutritional factors

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https://www.readbyqxmd.com/read/29446655/micrornas-as-molecular-targets-of-quercetin-and-its-derivatives-underlying-their-biological-effects-a-preclinical-strategy
#1
Dan Wang, Dongxiao Sun-Waterhouse, Feng Li, Li Xin, Dapeng Li
Quercetin is a well-known flavonoid naturally occurring in most of the plant foods and is often found in the human diet. It can act as a potent antioxidant and anti-inflammatory agent, and plays significant roles in the prevention of various chronic diseases. Recent findings revealed that quercetin could affect metabolic traits by regulating certain transcription factors or key proteins involved in cellular signal pathways and influencing the expression of functional genes along with related regulatory pathway(s), and that microRNAs (miRNAs) circulate in body fluids and are involved in post-transcriptional gene silencing and regulation of gene expression in various biological processes including development, proliferation, metabolism and inflammation...
February 15, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29431785/dietary-intake-of-glucono-%C3%AE-lactone-attenuates-skin-inflammation-and-contributes-to-maintaining-skin-condition
#2
Tetsuya Kuwano, Sawako Kawano, Daiji Kagawa, Yuka Yasuda, Yosuke Inoue, Takatoshi Murase
Skin properties are influenced by both external (e.g., ultraviolet [UV], chemicals, and bacteria) and internal factors (e.g., nutrition and hormones). Therefore, some dietary supplements are expected to improve skin conditions. Glucono-δ-lactone (GDL) is widely used as a food additive and is naturally present in wine, honey, and other foods. The aim of this study was to assess whether GDL improves skin condition and inflammation. In a double-blind, placebo-controlled study, 40 healthy Japanese male volunteers were randomly assigned to either the GDL (2000 mg day-1) or placebo group...
February 12, 2018: Food & Function
https://www.readbyqxmd.com/read/29408835/incidence-and-factors-correlating-with-incisional-hernia-following-open-bowel-resection-in-patients-with-inflammatory-bowel-disease-a-review-of-1000-patients
#3
Tomas M Heimann, Santosh Swaminathan, Adrian J Greenstein, Randolph M Steinhagen
OBJECTIVE: The aim of this study was to identify the incidence and factors associated with the development of incisional hernia (IH) in patients with inflammatory bowel disease (IBD) undergoing open bowel resections. BACKGROUND: Predisposing factors for IH have not been well studied in patients with IBD undergoing open bowel resection. The role of duration of the disease, nutritional factors, anti-inflammatory treatment, previous operative procedures, wound infection, and other complicating factors remains unclear...
March 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29392087/role-of-dietary-protein-and-muscular-fitness-on-longevity-and-aging
#4
REVIEW
Barbara Strasser, Konstantinos Volaklis, Dietmar Fuchs, Martin Burtscher
Muscle atrophy is an unfortunate effect of aging and many diseases and can compromise physical function and impair vital metabolic processes. Low levels of muscular fitness together with insufficient dietary intake are major risk factors for illness and mortality from all causes. Ultimately, muscle wasting contributes significantly to weakness, disability, increased hospitalization, immobility, and loss of independence. However, the extent of muscle wasting differs greatly between individuals due to differences in the aging process per se as well as physical activity levels...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29389614/identification-and-characterization-of-a-calcium-dependent-bacillopeptidase-from-bacillus-subtilis-cfr5-with-novel-kunitz-trypsin-inhibitor-degradation-activity
#5
Giliyaru Ramachandra Sharmila, Prakash Motiram Halami, Gonvindarajalu Venkateswaran
The cereals and pulses are considered to be an important component in the food chain due to their proteinaceous nature, but the presence of anti-nutritional factors (KTI) decreases their nutrient absorption rate. Kunitz trypsin inhibitors (KTI) reduce the bioavailability of trypsin and are the primary cause for the existence of various metabolic disorders. To overcome the inhibitory effect of KTI, a KTI degrading protein (BPC) was identified and characterized from Bacillus subtilis CFR5. BPC possesses 60% identity with bacillopeptidase of B...
January 2018: Food Research International
https://www.readbyqxmd.com/read/29388402/association-between-white-blood-cell-counts-within-normal-range-and-hemoglobin-a1c-in-a-korean-population
#6
Jae Won Hong, Jung Hyun Noh, Dong Jun Kim
BACKGROUND: We examined whether white blood cell (WBC) count levels within normal range, could be associated with hemoglobin A1c (HbA1c) levels. METHODS: Among the 11,472 people (≥19 years of age) who participated in the 2011 to 2012 Korea National Health and Nutrition Examination, subjects with chronic disease or illness, including 807 patients with diabetes currently taking anti-diabetic medications and/or 1,149 subjects with WBC levels <4,000 or >10,000/μL were excluded...
January 30, 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29371567/fungal-strategies-to-evade-the-host-immune-recognition
#7
REVIEW
Marco J Hernández-Chávez, Luis A Pérez-García, Gustavo A Niño-Vega, Héctor M Mora-Montes
The recognition of fungal cells by the host immune system is key during the establishment of a protective anti-fungal response. Even though the immune system has evolved a vast number of processes to control these organisms, they have developed strategies to fight back, avoiding the proper recognition by immune components and thus interfering with the host protective mechanisms. Therefore, the strategies to evade the immune system are as important as the virulence factors and attributes that damage the host tissues and cells...
September 23, 2017: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29362016/effects-of-fermented-soybean-meal-on-carbon-and-nitrogen-metabolisms-in-large-intestine-of-piglets
#8
Y T Zhang, D D Lu, J Y Chen, B Yu, J B Liang, J D Mi, S C L Candyrine, X D Liao
Fermented soybean meal (FSM), which has lower anti-nutritional factors and higher active enzyme, probiotic and oligosaccharide contents than its unfermented form, has been reported to improve the feeding value of soybean meal, and hence, the growth performance of piglets. However, whether FSM can affect the bacterial and metabolites in the large intestine of piglets remains unknown. This study supplemented wet-FSM (WFSM) or dry-FSM (DFSM) (5% dry matter basis) in the diet of piglets and investigated its effects on carbon and nitrogen metabolism in the piglets' large intestines...
January 24, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29356256/investigation-of-microalgal-carotenoid-content-using-coherent-anti-stokes-raman-scattering-cars-microscopy-and-spontaneous-raman-spectroscopy
#9
Jürgen Popp, Fisseha Bekele Legesse, Jan Rüger, Tobias Meyer, Michael Schmitt, Christoph Krafft
The yield of high-value products such as pigments that could be extracted from microalgae is affected by various nutritional and physical factors. Consequently, there is a need for fast visualization techniques that investigate the responses of individual microalgal cells to changing environmental conditions without introducing perturbations. Here we apply CARS microscopy to map the distribution of pigments in the diatoms Ditylum brightwellii and Stephanopyxis turris and report their relative change in response to varying light cycles using a marker based watershed analysis of the acquired images...
January 22, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29340580/population-specific-biomarkers-of-human-aging-a-big-data-study-using-south-korean-canadian-and-eastern-european-patient-populations
#10
Polina Mamoshina, Kirill Kochetov, Evgeny Putin, Franco Cortese, Alexander Aliper, Won-Suk Lee, Sung-Min Ahn, Lee Uhn, Neil Skjodt, Olga Kovalchuk, Morten Scheibye-Knudsen, Alex Zhavoronkov
Accurate and physiologically meaningful biomarkers for human aging are key to assessing anti-aging therapies. Given ethnic differences in health, diet, lifestyle, behaviour, environmental exposures and even average rate of biological aging, it stands to reason that aging clocks trained on datasets obtained from specific ethnic populations are more likely to account for these potential confounding factors, resulting in an enhanced capacity to predict chronological age and quantify biological age. Here we present a deep learning-based hematological aging clock modeled using the large combined dataset of Canadian, South Korean and Eastern European population blood samples that show increased predictive accuracy in individual populations compared to population-specific hematologic aging clocks...
January 11, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29331869/dietary-naringenin-supplementation-attenuates-experimental-autoimmune-encephalomyelitis-by-modulating-autoimmune-inflammatory-responses-in-mice
#11
Junpeng Wang, Ying Qi, Xinli Niu, Hua Tang, Simin Nikbin Meydani, Dayong Wu
Autoimmune disease is highly prevalent in humans. Since conventional therapies have limited efficacy and often come with significant side effects, nutrition may provide an alternative and complementary approach to improving autoimmune disorders. Naringenin, a flavonoid found in citrus fruits, has been shown to have anti-inflammatory and antioxidant properties. Using the experimental autoimmune encephalomyelitis (EAE), a rodent model of human multiple sclerosis, we determined the effect of dietary naringenin (0...
December 11, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29323428/enteral-nutrition-in-the-management-of-crohn-s-disease-reviewing-mechanisms-of-actions-and-highlighting-potential-venues-for-enhancing-the-efficacy
#12
REVIEW
Moftah H Alhagamhmad
Crohn's disease (CD) is a chronic condition that affects the gut and has adverse effects on growth and development. There is a global increase in the incidence and prevalence rates, and several factors are believed to contribute to this rise, including dietary habits. In contrast, the use of enteral nutrition (EN) as an exclusive source of nutrition is increasingly becoming the preferred induction treatment of pediatric CD patients in part to address the nutrition complications. However, EN therapy is considered less effective in adults with CD...
January 11, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29305994/impaired-intestinal-immune-barrier-and-physical-barrier-function-by-phosphorus-deficiency-regulation-of-tor-nf-%C3%AE%C2%BAb-mlck-jnk-and-nrf2-signalling-in-grass-carp-ctenopharyngodon-idella-after-infection-with-aeromonas-hydrophila
#13
Kang Chen, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Lin Feng
In aquaculture, the occurrence of enteritis has increased and dietary nutrition is considered as one of the major strategies to solve this problem. In the present study, we assume that dietary phosphorus might enhance intestinal immune barrier and physical barrier function to reduce the occurrence of enteritis in fish. To test this assumption, a total of 540 grass carp (Ctenopharyngodon idella) were investigated by feeding graded levels of available phosphorus (0.95-8.75 g/kg diet) and then infection with Aeromonas hydrophila...
January 3, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29305866/novel-and-rapid-osteoporosis-model-established-in-zebrafish-using-high-iron-stress
#14
Wenjuan Zhang, Jingjin Xu, Juhui Qiu, Cencan Xing, Xiumin Li, Bo Leng, Yi Su, Jinmei Lin, Jiaofen Lin, Xuqiao Mei, Yiqun Huang, Yutian Pan, Yu Xue
Osteoporosis is a global public health concern and, it can result from numerous pathogenic mechanisms, many of which are closely related with age, nutritional disorders, endocrine imbalance, or adverse drug side effects presented by glucocorticoids, heparin, and anti-epileptics. Given its wide range etiologies, it is crucial to establish an animal model of osteoporosis for use in screening potential drugs quickly and effectively. Previous research has reported that an accumulation of elevated iron in the body is an independent risk factor for osteoporosis...
January 3, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29244751/spirulina-extract-enhanced-a-protective-effect-in-type-1-diabetes-by-anti-apoptosis-and-anti-ros-production
#15
Jiyeong Lee, Arum Park, Mi Jeong Kim, Hee-Joung Lim, Young-Ah Rha, Hee-Gyoo Kang
Interest in the nutritional value and pharmacological activities of blue-green algae has gradually increased. Spirulina extracts show protective effects against apoptosis and inflammatory damage in various cell types. Here, we investigated the protective effects of extracts from Spirulina maxima in a cytokine-mediated type 1 diabetes model in vitro and in streptozotocin-induced diabetic Wistar rats in vivo. Interleukin-1β and interferon-gamma induced substantial cytotoxicity to RINm5F rat insulinoma cells, increasing nitric oxide (NO) production, nuclear factor-kappa B (NF-κB) activity, the expression of endoplasmic reticulum (ER) stress genes, and activation of mitogen-activated protein kinases and key genes related apoptosis...
December 15, 2017: Nutrients
https://www.readbyqxmd.com/read/29230097/the-molecular-mechanisms-of-regulation-on-usp2-s-alternative-splicing-and-the-significance-of-its-products
#16
REVIEW
Han-Qing Zhu, Feng-Hou Gao
Ubiquitin-specific protease 2 (USP2) has a regulatory function in cell growth or death and is involved in the pathogenesis of various diseases. USP2 gene can generate 7 splicing variants through alternative splicing, and 5 variants respectively as USP2-201, USP2-202, USP2-204, USP2-205, USP2-206 can encode proteins. The influence of circadian rhythm, nutrition and androgen on specific signaling molecules or cytokines can regulate the alternative splicing of USP2. Specifically, PKC activator, IL-1β, TNF-α, PDGF-BB, TGF-β1 are all regulatory factors for USP2's alternative splicing...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29229313/emerging-role-of-adipocytokines-in-type-2-diabetes-as-mediators-of-insulin-resistance-and-cardiovascular-disease
#17
REVIEW
Ravindran Jaganathan, Rajeswari Ravindran, Sugapriya Dhanasekaran
Adipose tissue is an enormously active endocrine organ, secreting various hormones, such as adiponectin, leptin, resistin and visfatin, together with classical cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). All these adipocytokines plays significant roles in the regulation of energy metabolism, glucose and lipid metabolism, reproduction, cardiovascular function and immunity. Adipocytokines are significantly regulated by nutritional status and can directly influence other organ systems, including brain, liver and skeletal muscle...
December 8, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29228436/the-effect-of-ventilator-mask-atomization-inhalation-of-ipratropium-bromide-and-budesonide-suspension-liquid-in-the-treatment-of-copd-in-acute-exacerbation-period-on-circulating-levels-of-inflammation-and-prognosis
#18
D-H Jiang, X Wang, L-S Liu, D-D Ji, N Zhang
OBJECTIVE: We investigated the effects of ventilator mask atomization inhalation of ipratropium bromide and budesonide suspension liquid in the treatment of acute exacerbation COPD (AECOPD) on circulating levels of inflammatory factors and prognosis. PATIENTS AND METHODS: A total of 86 cases of patients on ventilator support were randomly divided into control group and observation group with 43 cases each. The control group was administered routine treatment including basic disease treatment, anti-infection, maintenance of a stable internal environment, nutritional support, oxygen inhalation and so on...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29226031/sodium-salt-medium-chain-fatty-acids-and-bacillus-based-probiotic-strategies-to-improve-growth-and-intestinal-health-of-gilthead-sea-bream-sparus-aurata
#19
Paula Simó-Mirabet, M Carla Piazzon, Josep Alvar Calduch-Giner, Álvaro Ortiz, Mónica Puyalto, Ariadna Sitjà-Bobadilla, Jaume Pérez-Sánchez
Background: The increased demand for fish protein has led to the intensification of aquaculture practices which are hampered by nutritional and health factors affecting growth performance. To solve these problems, antibiotics have been used for many years in the prevention, control and treatment against disease as well as growth promoters to improve animal performance. Nowadays, the use of antibiotics in the European Union and other countries has been completely or partially banned as a result of the existence of antibiotic cross-resistance...
2017: PeerJ
https://www.readbyqxmd.com/read/29220416/the-effectiveness-and-limitation-of-the-national-childhood-hepatitis-a-vaccination-program-in-the-republic-of-korea-findings-from-the-korean-national-health-and-nutrition-examination-survey-knhanes-2015
#20
Juwon Lim, Kyuwoong Kim, Seulggie Choi, Sang Min Park
BACKGROUND: Vaccination for hepatitis A virus (HAV) has been implemented as one of the national vaccination programs despite the epidemiological transition of HAV in the Republic of Korea. While the national HAV vaccination program is largely associated with the shift of socioeconomic trend in the country, concerns have been raised on the effectiveness of the HAV immunization. The objective of this study was to examine the epidemiological trend of HAV and assess the effectiveness of the nationwide HAV vaccination policy based on a nationally representative sample of the Korean population collected in 2015...
2017: PloS One
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