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Anti-nutritional factors

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https://www.readbyqxmd.com/read/28339732/exploring-the-in-vivo-digestion-of-plant-proteins-in-broiler-chickens
#1
E Recoules, H Sabboh-Jourdan, A Narcy, M Lessire, G Harichaux, V Labas, M J Duclos, S Réhault-Godbert
The use of various protein sources (industry by-products, proteaginous) in poultry diets requires a greater understanding of protein digestion mechanisms. The aim of this study was to characterize the molecular actors required for protein digestion in broilers fed 4 different diets containing soybean meal, rapeseed meal, pea, or corn distiller's dried grain with solubles as the only protein source. The digesta of the digestive tract segments were collected and soluble proteins were analyzed by SDS-PAGE. SDS-PAGE analyses revealed 5 ubiquitous bands in digesta of all digestive tract segments regardless of the diet, whereas 3 bands were diet-specific...
February 23, 2017: Poultry Science
https://www.readbyqxmd.com/read/28335094/growth-and-physiological-responses-of-broiler-chickens-to-diets-containing-raw-full-fat-soybean-meal-and-supplemented-with-a-high-impact-microbial-protease
#2
Mammo Mengesha Erdaw, Shubiao Wu, Paul A Iji, Rider A Perez-Maldonado
Objective: This study was to evaluate the change and function of the pancreas, and small intestine in relation to growth performance of broilers on diets supplemented with raw soybean meal (RSBM) and protease. Samples of test ingredients and diets, after mixing and prior to being used were also assessed on contents of anti-nutritional factors. Methods: A 3 x 3 factorial study was used, with three levels of RSBM (commercial SBM was replaced by RSBM at 0, 10 or 20%) and protease (0...
March 21, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28315697/the-role-of-the-tor-pathway-in-mediating-the-link-between-nutrition-and-longevity
#3
REVIEW
Oleh Lushchak, Olha Strilbytska, Veronika Piskovatska, Kenneth B Storey, Alexander Koliada, Alexander Vaiserman
The target of rapamycin (TOR) pathway integrates signals from extracellular and intracellular agents, such as growth factors, nutrients, mediators of energy balance, oxygen availability and other environmental cues. It allows the regulation of multiple cellular processes including protein and lipid synthesis, ribosome biogenesis, autophagy and metabolic processes. Being conserved across different phyla, TOR regulates longevity of various organisms in response to dietary conditions. In this review we described the main components of the TOR pathway and its upstream effectors and downstream processes in relation to aging...
March 15, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28314621/docosahexaenoic-acid-dha-an-essential-nutrient-and-a-nutraceutical-for-brain-health-and-diseases
#4
REVIEW
Grace Y Sun, Agnes Simonyi, Kevin L Fritsche, Dennis Y Chuang, Mark Hannink, Zezong Gu, C Michael Greenlief, Jeffrey K Yao, James C Lee, David Q Beversdorf
Docosahexaenoic acid (DHA), a polyunsaturated fatty acid (PUFA) enriched in phospholipids in the brain and retina, is known to play multi-functional roles in brain health and diseases. While arachidonic acid (AA) is released from membrane phospholipids by cytosolic phospholipase A2 (cPLA2), DHA is linked to action of the Ca(2+)-independent iPLA2. DHA undergoes enzymatic conversion by 15-lipoxygenase (Alox 15) to form oxylipins including resolvins and neuroprotectins, which are powerful lipid mediators. DHA can also undergo non-enzymatic conversion by reacting with oxygen free radicals (ROS), which cause the production of 4-hydoxyhexenal (4-HHE), an aldehyde derivative which can form adducts with DNA, proteins and lipids...
March 10, 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28303053/comparison-of-color-anti-nutritional-factors-minerals-phenolic-profile-and-protein-digestibility-between-hard-to-cook-and-easy-to-cook-grains-from-different-kidney-bean-phaseolus-vulgaris-accessions
#5
Naincy Parmar, Narpinder Singh, Amritpal Kaur, Sheetal Thakur
The present study was aimed to evaluate the differences among anti-nutritional factors in relation to mineral absorption and protein digestibility of Easy-to-cook (ETC) and Hard-to-cook (HTC) grains from different kidney bean (KB) accessions.HTC grains showed lower a* (redness to yellowness) and b* (greenness to blueness) values and L* value than ETC grains. HTC grains had significantly higher Ca and Zn and lower Cu, Mn and Fe than ETC grains. ETC and HTC grains showed significant variation in mineral, total phenolic content (TPC), tannin and phytic acid content...
March 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28303048/studies-on-physico-chemical-and-cooking-characteristics-of-rice-bean-varieties-grown-in-ne-region-of-india
#6
Rejaul Hoque Bepary, D D Wadikar, Seuji Borah Neog, P E Patki
Rice bean (Vigna umbellata) is grown in South and Southeast Asia, and the bean has gained importance due to its nutritional strength in terms of dietary fiber, quality protein and minerals. In current study, the nutritional and functional components, cooking and thermo-gravimetric properties of eleven rice bean varieties from NE India were investigated. Results revealed that the major nutrients among the varieties ranged as follows: 54.21-60.49% carbohydrates, 15.64-21.60% protein, 1.22-2.3% fat, 5.53-6.56% crude fibre, 3...
March 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28299573/mkrn3-levels-in-girls-with-central-precocious-puberty-and-correlation-with-sexual-hormone-levels-a-pilot-study
#7
Anna Grandone, Grazia Cirillo, Marcella Sasso, Carlo Capristo, Gianluca Tornese, Pierluigi Marzuillo, Caterina Luongo, Giuseppina Rosaria Umano, Adalgisa Festa, Ruggero Coppola, Emanuele Miraglia Del Giudice, Laura Perrone
PURPOSE: Recently, mutations of makorin RING-finger protein 3 (MKRN3) have been described in familial central precocious puberty. Serum levels of this protein decline before the pubertal onset in healthy girls and boys. The aim of the study is to investigate MKRN3 circulating levels in patients with central precocious puberty. METHODS: We performed an observational cross-sectional study. We enrolled 17 patients with central precocious puberty aged 7 years (range: 2-8 years) and breast development onset <8 years; 17 prepubertal control age-matched patients aged 6...
March 15, 2017: Endocrine
https://www.readbyqxmd.com/read/28294972/potential-impact-of-diet-on-treatment-effect-from-anti-tnf-drugs-in-inflammatory-bowel-disease
#8
REVIEW
Vibeke Andersen, Axel Kornerup Hansen, Berit Lilienthal Heitmann
We wanted to investigate the current knowledge on the impact of diet on anti-TNF response in inflammatory bowel diseases (IBD), to identify dietary factors that warrant further investigations in relation to anti-TNF treatment response, and, finally, to discuss potential strategies for such investigations. PubMed was searched using specified search terms. One small prospective study on diet and anti-TNF treatment in 56 patients with CD found similar remission rates after 56 weeks among 32 patients with good compliance that received concomitant enteral nutrition and 24 with poor compliance that had no dietary restrictions (78% versus 67%, p = 0...
March 15, 2017: Nutrients
https://www.readbyqxmd.com/read/28290237/multiple-nutritional-factors-and-the-risk-of-hashimoto-s-thyroiditis
#9
Shiqian Hu, Margaret P Rayman
Background Hashimoto's Thyroiditis (HT) is considered to be the most common autoimmune disease. It is currently accepted that genetic susceptibility, environmental factors and immune disorders contribute to its development. Regarding nutritional factors, evidence implicates high iodine intake, deficiencies of selenium and iron with a potential relevance of vitamin D status. To elucidate the role of nutritional factors in the risk, pathogenesis and treatment of Hashimoto's Thyroiditis (HT), PubMed and the Cochrane Library were searched for publications on iodine, iron, selenium and vitamin D and risk/treatment of HT...
March 14, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28286717/sorghum-and-wheat-differentially-affect-caecal-microbiota-and-associated-performance-characteristics-of-meat-chickens
#10
Eduardo Crisol-Martínez, Dragana Stanley, Mark S Geier, Robert J Hughes, Robert J Moore
This study compared the effects of wheat- and sorghum-based diets on broiler chickens. The growth performance and caecal microbial community of chickens were measured and correlations between productivity and specific gut microbes were observed. Cobb broilers 15 days of age were individually caged and two dietary treatments were used, one with a wheat-based diet (n = 48) and another one with a sorghum-based diet (n = 48). Growth performance measurements were taken over a 10 day period and samples for microbiota analysis were taken at the end of that period...
2017: PeerJ
https://www.readbyqxmd.com/read/28284063/soybean-polar-lipids-differently-impact-adipose-tissue-inflammation-and-the-endotoxin-transporters-lbp-and-scd14-in-flaxseed-vs-palm-oil-rich-diets
#11
Manon Lecomte, Leslie Couëdelo, Emmanuelle Meugnier, Emmanuelle Loizon, Pascale Plaisancié, Annie Durand, Alain Géloën, Florent Joffre, Carole Vaysse, Marie-Caroline Michalski, Fabienne Laugerette
Obesity and type 2 diabetes are nutritional pathologies, characterized by a subclinical inflammatory state. Endotoxins are now well recognized as an important factor implicated in the onset and maintain of this inflammatory state during fat digestion in high-fat diet. As a preventive strategy, lipid formulation could be optimized to limit these phenomena, notably regarding fatty acid profile and PL emulsifier content. Little is known about soybean polar lipid (SPL) consumption associated to oils rich in saturated FA vs...
February 21, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28279889/polysaccharide-from-angelica-sinensis-ameliorates-high-fat-diet-and-stz-induced-hepatic-oxidative-stress-and-inflammation-in-diabetic-mice-by-activating-the-sirt1-ampk-pathway
#12
Kaiping Wang, Zhuohong Tang, Jinglin Wang, Peng Cao, Qiang Li, Weizhi Shui, Hongjing Wang, Ziming Zheng, Yu Zhang
Polysaccharide from Angelica sinensis (Oliv.) Diels (ASP) possesses many bioactivities, such as hematopoiesis, anti-inflammation, antioxidation and metabolism regulation. The aim of this study was to investigate the mechanisms underlying the protection of a combination of high-fat diet and streptozotocin-induced liver damage in diabetic Balb/c mice by ASP. Results showed that ASP had beneficial effects on ameliorating hyperglycemia, dyslipidemia and liver injury. Moreover, mechanistic study for the liver-protective role in vivo demonstrated that ASP enhanced the activities of superoxide dismutase and glutathione peroxidase and increased the glutathione content, which resulted in the reduction of hepatic reactive oxygen species (ROS) and malondialdehyde, and reduced the protein expression levels of liver IKKα/NF-κB/p-IκBα and the concentrations of serum tumor necrosis factor-α/interleukin-6...
February 10, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28267434/dietary-phytochemicals-in-the-protection-against-oxysterol-induced-damage
#13
REVIEW
Antonio Cilla, Amparo Alegría, Alessandro Attanzio, Guadalupe Garcia-Llatas, Luisa Tesoriere, Maria A Livrea
The intake of fruits and vegetables is associated with reduced incidence of many chronic diseases. These foods contain phytochemicals that often possess antioxidant and free radical scavenging capacity and show anti-inflammatory action, which are also the basis of other bioactivities and health benefits, such as anticancer, anti-aging, and protective action for cardiovascular diseases, diabetes mellitus, obesity and neurodegenerative disorders. Many factors can be included in the etiopathogenesis of all of these multifactorial diseases that involve oxidative stress, inflammation and/or cell death processes, oxysterols, i...
March 3, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28263744/gpr120-in-adipocytes-has-differential-roles-in-the-production-of-pro-inflammatory-adipocytokines
#14
Arif Ul Hasan, Koji Ohmori, Takeshi Hashimoto, Kazuyo Kamitori, Fuminori Yamaguchi, Takahisa Noma, Junsuke Igarashi, Kazuhito Tsuboi, Masaaki Tokuda, Akira Nishiyama, Masakazu Kohno
How nutritional excess leads to inflammatory responses in metabolic syndrome is not well characterized. Here, we evaluated the effects of ω-3 polyunsaturated fatty acid specific G-protein coupled receptor 120 (GPR120) activation on inflammatory pathways in adipocytes, and the influence of this process on macrophage migration. Using 3T3-L1 adipocytes, we found that agonizing GPR120 using its synthetic ligand, GSK137647, attenuated both basal and lipopolysaccharide-induced production of interleukin-6 (IL-6) and C-C motif chemokine ligand 2 (CCL2)...
March 3, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28258980/in-situ-synthesis-of-exopolysaccharides-by-leuconostoc-spp-and-weissella-spp-and-their-rheological-impacts-in-fava-bean-flour
#15
Yan Xu, Yaqin Wang, Rossana Coda, Elina Säde, Päivi Tuomainen, Maija Tenkanen, Kati Katina
Fava bean flour is regarded as a potential plant-based protein source, but the addition of it at high concentration is restricted by its poor texture-improving ability and by anti-nutritional factors (ANF). Exopolysaccharides (EPS) produced by lactic acid bacteria (LAB) are regarded as good texture modifiers. In this study, fava bean flour was fermented with Leuconostoc spp. and Weissella spp. with or without sucrose addition, in order to evaluate their potential in EPS production. The contents of free sugars, organic acids, mannitol and EPS in all fermented fava bean doughs were measured...
February 21, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28258307/nutrition-for-diabetic-retinopathy-plummeting-the-inevitable-threat-of-diabetic-vision-loss
#16
REVIEW
Yashodhara Sharma, Sandeep Saxena, Arvind Mishra, Anita Saxena, Shankar Madhav Natu
Diabetic retinopathy (DR) is among the leading causes of preventable blindness. Hyperglycemia, hypertension, hyperlipidemia and anemia majorly predispose its pathogenesis. The current treatment modalities of DR include laser photocoagulation therapy, intravitreal corticosteroids, intravitreal anti-vascular endothelial growth factor (VEGF) agents and vitreo-retinal surgery which are costly, highly invasive, unproven for prolonged use and opted in advanced stages of DR. By then retina already encounters a vast damage...
March 3, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28243151/anemia-among-adult-hiv-patients-in-ethiopia-a-hospital-based-cross-sectional-study
#17
Hermela Melese, Molla Mesele Wassie, Haile Woldie, Abilo Tadesse, Nebiyu Mesfin
BACKGROUND: Anemia is a major public health problem in HIV patients around the world. It has a negative effect on the quality of life of HIV patients and progression of the HIV disease. In the sub-Saharan African setting, including Ethiopia where both HIV infection and under-nutrition are expected to be high, there is a paucity of data on the matter. This study was aimed to reveal the magnitude and factors associated with anemia among adult HIV patients in Debre-Tabor Hospital, northwest Ethiopia...
2017: HIV/AIDS: Research and Palliative Care
https://www.readbyqxmd.com/read/28225051/low-muscle-mass-at-initiation-of-anti-tnf-therapy-for-inflammatory-bowel-disease-is-associated-with-early-treatment-failure-a-retrospective-analysis
#18
D Q Holt, P Varma, B J G Strauss, A S Rajadurai, G T Moore
BACKGROUND/OBJECTIVES: Delayed treatment failure occurs in a significant proportion of inflammatory bowel disease (IBD) patients treated with tumor necrosis factor-alpha (TNF) antagonists. Identification of predictors of loss of response (LOR) may help to optimize therapy. We sought to determine whether body composition parameters at the commencement of anti-TNF therapy were associated with earlier treatment failure. SUBJECTS/METHODS: A retrospective cohort study was performed on 68 patients who had undergone cross-sectional abdominal imaging coincident with the commencement of anti-TNF drugs...
February 22, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28225048/thiamine-deficiency-oxidative-metabolic-pathways-and-ethanol-induced-neurotoxicity-how-poor-nutrition-contributes-to-the-alcoholic-syndrome-as-marchiafava-bignami-disease
#19
REVIEW
L M P Fernandes, F R Bezerra, M C Monteiro, M L Silva, F R de Oliveira, R R Lima, E A Fontes-Júnior, C S F Maia
Ethanol is an important risk factor for the occurrence of several brain disorders that depend on the amount, period and frequency of its consumption. Chronic use of ethanol often leads to the development of neurodegenerative syndromes, which cause morphological and functional impairments such as foetal alcohol syndrome in newborns exposed to ethanol during pregnancy, Wernicke-Korsakoff Syndrome and, more rarely, Marchiafava-Bignami disease (MBD). MBD is characterized by primary degeneration of the corpus callosum, without inflammation and is associated with oxidative stress and hypovitaminosis, as well as altered mental status, to mention dementia, seizures, depression and so on...
February 22, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28222496/the-integrins-involved-in-soybean-agglutinin-induced-cell-cycle-alterations-in-ipec-j2
#20
Li Pan, Yuan Zhao, Zhijie Yuan, Mohammed Hamdy Farouk, Shiyao Zhang, Nan Bao, Guixin Qin
Soybean agglutinin (SBA) is an anti-nutritional factor of soybean, affecting cell proliferation and inducing cytotoxicity. Integrins are transmembrane receptors, mediating a variety of cell biological processes. This research aims to study the effects of SBA on cell proliferation and cell cycle progression of the intestinal epithelial cell line from piglets (IPEC-J2), to identify the integrin subunits especially expressed in IPEC-J2s, and to analyze the functions of these integrins on IPEC-J2 cell cycle progression and SBA-induced IPEC-J2 cell cycle alteration...
February 2017: Molecules and Cells
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