Dorian R A Swarts, Mieke E R Henfling, Leander Van Neste, Robert-Jan van Suylen, Anne-Marie C Dingemans, Winand N M Dinjens, Annick Haesevoets, Martina Rudelius, Erik Thunnissen, Marco Volante, Wim Van Criekinge, Manon van Engeland, Frans C S Ramaekers, Ernst-Jan M Speel
PURPOSE: Pulmonary carcinoids are well-differentiated neuroendocrine tumors showing usually a favorable prognosis. However, there is a risk for late recurrence and/or distant metastasis. Because histologic classification in typical and atypical carcinoids is difficult and its reliability to predict disease outcome varies, we evaluated three genes as potential prognostic markers, that is, orthopedia homeobox (OTP), CD44, and rearranged during transfection (RET). EXPERIMENTAL DESIGN: These genes were analyzed in 56 frozen carcinoids by quantitative real-time PCR (qRT-PCR)...
April 15, 2013: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research