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https://www.readbyqxmd.com/read/29768638/gestational-trophoblastic-neoplasia-after-ectopic-molar-pregnancy-clinical-diagnostic-and-therapeutic-aspects
#1
Consuelo Lozoya López, Vania Gloria Silami Lopes, Fabiana Rodrigues Resende, Jessica Lara Steim, Lilian Padrón, Sue Yazaki Sun, Edward Araujo Júnior, Antonio Braga
This report presents the case of a patient with gestational trophoblastic neoplasia after a partial hydatidiform mole formed in the Fallopian tube. Ectopic molar pregnancy is a rare condition, with an estimated incidence of 1 in every 20,000 to 100,000 pregnancies; less than 300 cases of it have been reported in the Western literature. The present report is important because it presents current diagnostic criteria for this rare condition, which has been incorrectly diagnosed in the past, not only morphologically but also immunohistochemically...
May 16, 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29759106/stage-specific-feed-intake-restriction-differentially-regulates-placental-traits-and-proteome-of-goats
#2
Qiongxian Yan, Juanzhi Xu, Xiaosong Wu, Dingding Su, Zhiliang Tan
A total of twenty-four healthy twin-bearing Liuyang black goats were allocated to two trials. In Trial 1, twelve goats received either the control diet (CG, n 6, 100 % feed) or restricted diet (RG, n 6, 60 % feed of CG) from gestation days 26 to 65 after synchronisation. In Trial 2, the remaining goats were randomly and equally divided into two treatments: CG and RG from days 95 to 125 of gestation. Placental traits, fetal weight, serum parameters, nitric oxide (NO), angiogenesis gene expression and cotyledon proteome were measured at the end of each trial...
May 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29757875/surgery-and-platinum-etoposide-based-chemotherapy-for-the-treatment-of-epithelioid-trophoblastic-tumor
#3
Janelle Sobecki-Rausch, Abigail Winder, Kruti P Maniar, Anna V Hoekstra, Emily Berry, Karen Novak, John R Lurain
OBJECTIVE: Epithelioid trophoblastic tumor (ETT) is a rare variant of gestational trophoblastic neoplasia that develops from chorionic-type intermediate trophoblast, simulates carcinoma, presents years after a pregnancy event, is associated with low or normal human chorionic gonadotropin levels, and is relatively resistant to chemotherapy. Our aim was to identify the role of surgery in combination with platinum/etoposide-based chemotherapy in the management of both localized and metastatic ETT...
May 4, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29748248/bromodomain-protein-brd4-is-increased-in-human-placentas-from-women-with-early-onset-preeclampsia
#4
Stella Liong, Gillian Barker, Martha Lappas
Preeclampsia affects 5% of all pregnancies and is a serious disorder of pregnancy, characterised by high maternal blood pressure, placental hypoxia, fluid retention (oedema) and proteinuria. Women with preeclampsia are associated with exaggerated levels of pro-inflammatory cytokines, chemokines and anti-angiogenic factors such as soluble fms-like tyrosine kinase-1 (sFLT1). Studies in non-gestational tissues have described the bromodomain (BRD) and extraterminal family of proteins, in particular BRD4 to play a critical role in propagating inflammation and is currently a therapeutic target for treating cancer, lung inflammation and asthma...
June 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29740884/bovine-foetal-sex-determination-different-dna-extraction-and-amplification-approaches-for-efficient-livestock-production
#5
M Ristanic, Lj Stanisic, M Maletic, U Glavinic, V Draskovic, N Aleksic, Z Stanimirovic
Foetal sex determination using polymerase chain reaction (PCR) in mammals is based on the amplification of gender-specific foetal DNA sequences circulating in maternal blood. The bovine synepitheliochorial placenta does not allow a direct contact between the trophoblast and the maternal blood, resulting in difficult passage of foetal DNA and, consequently, its very small amounts in maternal bloodstream. Circulating cell-free foetal DNA (ccffDNA) encompasses short nucleotide fragments (300-600 bp) in maternal circulation...
May 8, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29740848/control-of-the-inflammatory-response-during-pregnancy-potential-role-of-vip-as-a-regulatory-peptide
#6
Rosanna Ramhorst, Guillermina Calo, Daniel Paparini, Daiana Vota, Vanesa Hauk, Lucila Gallino, Fatima Merech, Esteban Grasso, Claudia Pérez Leirós
A network of cell-cell communications through contact and soluble factors supports the maternal-placental interaction and provides a suitable environment for fetal growth. Trophoblast cells take center stage at these loops: they interact with maternal leukocytes to sustain the varying demands of gestation, and they synthesize hormones, cytokines among other factors that contribute to the maintenance of immune homeostasis. Here, we discuss vasoactive intestinal peptide (VIP) and its potential as a regulatory neuropeptide in pregnancy...
May 8, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29737470/recurrent-complete-hydatidiform-mole-where-we-are-is-there-a-safe-gestational-horizon-opinion-and-mini-review
#7
REVIEW
Ioannis Kalogiannidis, Kallirhoe Kalinderi, Michail Kalinderis, Dimosthenis Miliaras, Basil Tarlatzis, Apostolos Athanasiadis
Benign hydatidiform mole, complete or partial, is the most common type of gestational trophoblastic disease (GTD) characterised by excessive trophoblastic proliferation and abnormal embryonic development. Although most complete hydatidiform moles (CHMs) are diploid androgenetic, a few cases of CHMs are biparental, characterised by recurrence and familial clustering. In these rare cases, mutations in NLRP7 or KHDC3L genes, associated with maternal imprinting defects, have been implicated. Current data regarding future pregnancy options in hydatidiform moles are discussed and our opinion is presented based on an incidence that took place in our hospital with a woman with consecutive molar pregnancies...
May 8, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29724428/acr-appropriateness-criteria-%C3%A2-first-trimester-vaginal-bleeding
#8
Douglas L Brown, Ann Packard, Katherine E Maturen, Sandeep Prakash Deshmukh, Kika M Dudiak, Tara L Henrichsen, Benjamin J Meyer, Liina Poder, Elizabeth A Sadowski, Thomas D Shipp, Lynn Simpson, Therese M Weber, Carolyn M Zelop, Phyllis Glanc
Vaginal bleeding is not uncommon in the first trimester of pregnancy. The majority of such patients will have a normal intrauterine pregnancy (IUP), a nonviable IUP, or an ectopic pregnancy. Ultrasound (US) is the primary imaging modality in evaluation of these patients. US, along with clinical observations and serum human chorionic gonadotropin levels, can usually distinguish these causes. Although it is important to diagnose ectopic pregnancies and nonviable IUPs, one should also guard against injury to normal pregnancies due to inappropriate treatment with methotrexate or surgical intervention...
May 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29723645/a-novel-treatment-for-cervical-and-cesarean-section-scar-pregnancies-by-transvaginal-injection-of-absolute-ethanol-to-trophoblasts-its-efficacy-in-19-cases
#9
Hisao Osada, Shokichi Teramoto, Hirotsune Kaijima, Tomoya Segawa, Osamu Miyauchi, Masaji Nagaishi, Makio Shozu, Keiichi Kato, Victor Gomel
STUDY OBJECTIVE: To evaluate the efficacy of a non-surgical treatment for cervical pregnancies (CP) and cesarean section scar pregnancies (CSP) DESIGN: Canadian Task Force Classification III SETTING: Private assisted reproductive technology practice PATIENTS: Nineteen women with CP (16 cases) or CSP (3 cases), including 6 patients with positive fetal heartbeat INTERVENTION: Transvaginal local injection of absolute ethanol (AE) into the hyperechoic ring (lacunar space) around the gestational sac under ultrasound guidance MEASUREMENTS AND MAIN RESULTS: Serum beta-human chorionic gonadotropin (β-hCG) was measured at frequent intervals, and ultrasound and/or magnetic resonance imaging was used to observe the gestational sac...
April 30, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29707399/placental-histomorphology-in-a-case-of-double-trisomy-48-xxx-18
#10
Sujal I Shah, Lisa Dyer, Jerzy Stanek
Background: Approximately 50% of early spontaneous abortions are found to have chromosomal abnormalities. In these cases, certain histopathologic abnormalities are suggestive of, although not diagnostic for, the presence of chromosomal abnormalities. However, placental histomorphology in cases of complex chromosomal abnormalities, including double trisomies, is virtually unknown. Case Report: We present the case of a 27-year-old G3P22002 female presenting at 19 weeks and 1 day of gestation by last menstrual period for scheduled prenatal visit...
2018: Case Reports in Pathology
https://www.readbyqxmd.com/read/29697667/-features-of-the-pathogenesis-of-the-placenta-growing-in-the-scar-after-cesarean-section
#11
I V Barinova, N I Kondrikov, I N Voloshchuk, M A Chechneva, N A Shchukina, V A Petrukhin
OBJECTIVE: to investigate the structural and pathogenetic features of pathological placental attachment in the scar after cesarean section. MATERIAL AND METHODS: The investigators explored 12 uteri; 11 of which were removed with placentas at 9 to 38 weeks' gestation (one in the first trimester, three at 18-22 weeks, two at 32-35 weeks, and five at 37-38 weeks); one uterus was removed after an artificial abortion at 12 weeks' gestation in the scar, as well as the scars excised in the first trimester in non-developing (n=4) and progressive (n=2) pregnancies...
2018: Arkhiv Patologii
https://www.readbyqxmd.com/read/29688572/enhanced-expression-of-ifi16-and-rig-i-in-human-third-trimester-placentas-following-hsv-1-infection
#12
Agnieszka Jabłońska, Mirosława Studzińska, Patrycja Suski, Jarosław Kalinka, Edyta Paradowska
The innate immune response in the placenta depends on the ability of maternal immune cells and fetal trophoblast cells to detect and eliminate invading pathogens through germline-encoded pattern recognition receptors (PRRs). In the present study, we analyzed the transcripts and protein expression of IFI16, MDA5, RIG-I, and TLR3 in third-trimester human placentas and investigated cytokine profiles generated during herpes simplex type 1 (HSV-1) infection. Decidual and chorionic villous biopsies (38-42 week of gestation) were obtained from healthy women immediately after a cesarean section...
April 24, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29679053/pregnancy-associated-diamine-oxidase-originates-from-extravillous-trophoblasts-and-is-decreased-in-early-onset-preeclampsia
#13
Philipp Velicky, Karin Windsperger, Karin Petroczi, Sophie Pils, Birgit Reiter, Tamara Weiss, Sigrid Vondra, Robin Ristl, Sabine Dekan, Christian Fiala, David E Cantonwine, Thomas F McElrath, Bernd Jilma, Martin Knöfler, Thomas Boehm, Jürgen Pollheimer
Human extravillous trophoblast (EVT) invasion of the pregnant uterus constitutes a pivotal event for the establishment of the maternal-fetal interface. Compromised EVT function manifesting in inadequate arterial remodeling is associated with the severe pregnancy disorder early-onset preeclampsia (eoPE). Recent studies suggest that EVTs invade the entire uterine vasculature including arteries, veins and lymphatics in the first trimester of pregnancy. We therefore hypothesized that EVT-derived factors accumulate in the circulation of pregnant women early in gestation and may serve to predict eoPE...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29673680/two-cesarean-deliveries-after-hemi-hysterectomy-due-to-gestational-trophoblastic-neoplasia
#14
Kentaro Kai, Yasushi Kawano, Mitsutake Yano, Mamiko Okamoto, Eiichi Hori, Kaei Nasu, Hisashi Narahara
OBJECTIVE: Although uterine didelphys per se is not associated with an impaired ability to conceive, the association between uterine anomalies and gestational trophoblastic neoplasia (GTN) remains unclear. The management of chemotherapy-resistant GTN in women with uterine didelphys raises a new issue regarding whether to perform a hemi-hysterectomy. CASE REPORT: A 23-year-old, gravida 1, para 0 Japanese woman was referred with a failed intermittent cervical dilatation for hematometra...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29668580/metastatic-epithelioid-trophoblastic-tumor-of-the-lung-a-case-report
#15
Wangjun Lei, Fangbiao Zhang, Chunhui Zheng, Chun Zhao, Shaosong Tu, Yingwei Bao
RATIONALE: Epithelioid trophoblastic tumor (ETT) is a very rare form of gestational trophoblastic disease (GTD) which arises from neoplastic proliferation of intermediate trophoblasts. Metastatic ETT of the lung is extremely rare in postmenopausal women. PATIENT CONCERNS: Here we describe a 50-year-old woman with a metastatic ETT of the lung showing increasing tracer uptake at PET/CT. DIAGNOSIS: Hematoxylin-eosin staining showed a tumor composed of nests of epithelioid cells with necrotic debris and peritumoral hyaline-like material...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29659791/human-placental-growth-hormone-variant-in-pathological-pregnancies
#16
Shutan Liao, Mark H Vickers, Joanna L Stanley, Philip N Baker, Jo K Perry
Growth hormone (GH), an endocrine hormone primarily secreted from the anterior pituitary, stimulates growth, cell reproduction and regeneration and is a major regulator of postnatal growth. Humans have two GH genes which encode two versions of GH proteins: a pituitary version (GH-N/GH1), and a placental GH variant (GH-V/GH2) which is expressed in the syncytiotrophoblast and extravillous trophoblast cells of the placenta. During pregnancy, placental GH replaces pituitary GH in the maternal circulation at mid-late gestation as the major circulating form of GH...
April 6, 2018: Endocrinology
https://www.readbyqxmd.com/read/29659388/imaging-of-metastatic-epithelioid-trophoblastic-tumor-with-18f-fdg-pet-ct
#17
Tirth Patel, Jorge Oldan
Epithelioid trophoblastic tumors are exceptionally rare malignant forms of gestational trophoblastic neoplasia arising from the placenta. We present here a case of a 33-year-old woman with an epithelioid trophoblastic tumor with metastatic disease to the lungs that was initially thought to represent cervical carcinoma. After appropriate diagnosis and treatment, the tumor responded to therapy and was in remission. The cancer recurred 5 years later with new lung metastases. F-FDG PET/CT was used for initial tumor staging, to evaluate treatment response, and to help detect the recurrence...
April 13, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29629964/efficacy-and-safety-of-second-line-5-day-dactinomycin-in-case-of-methotrexate-failure-for-gestational-trophoblastic-neoplasia
#18
Catherine Prouvot, François Golfier, Jérôme Massardier, Benoit You, Jean-Pierre Lotz, Sophie Patrier, Mojgan Devouassoux, Anne-Marie Schott, Touria Hajri, Pierre-Adrien Bolze
OBJECTIVE: The objective of this study was to evaluate the characteristics and outcomes of patients treated for gestational trophoblastic neoplasia (GTN) with second-line 5-day dactinomycin after failed first-line 8-day methotrexate. METHODS: From 1999 to 2017, patients with methotrexate resistant GTN treated with second line dactinomycin were identified at the French Trophoblastic Disease Reference Center. Using univariate and multivariate analysis, we identified significant predictive factors of second line dactinomycin failure...
April 6, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29626977/ifn%C3%AF-mediates-chemotaxis-motility-metabolism-and-ck18-downregulation-in-bovine-trophoblast-cells-in-vitro-via-stat1-and-mapk42-44-signaling
#19
C Loch, J-D Haeger, C Pfarrer
INTRODUCTION: IFNτ is the ruminant pregnancy recognition signal. In the study we investigated the autocrine influence of IFNτ on bovine F3 trophoblast cells. In detail chemotaxis, motility, metabolism, cell polarisation (CK18; ezrin) and the underlying classical (STAT1) and non-classical (MAPK42/44) signaling pathways were examined. METHODS: Cellular signaling was analysed by densitometric Western blot (STAT1, MAPK42/44, proteinkinase B) and RT-PCR (IFNAR1, -2)...
April 2018: Placenta
https://www.readbyqxmd.com/read/29615475/micrornas-crucial-regulators-of-placental-development
#20
Heyam Hayder, Jacob O'Brien, Uzma Nadeem, Chun Peng
MicroRNAs (miRNAs) are small non-coding single-stranded RNA that are integral to a wide range of cellular processes mainly through the regulation of translation and mRNA stability of their target genes. The placenta is a transient organ that exists throughout gestation in mammals, facilitating nutrient and gas exchange and waste removal between the mother and the fetus. MiRNAs are expressed in the placenta and many studies have shown that miRNAs play an important role in regulating trophoblast differentiation, migration, invasion, proliferation, apoptosis, vasculogenesis/angiogenesis, and cellular metabolism...
April 3, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
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