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https://www.readbyqxmd.com/read/28454241/transthyretin-regulates-the-migration-and-invasion-of-jeg-3-cells
#1
Liyun Gong, Lei Zhu, Shuzhen Wang, Zhenyu Zhang
Preeclampsia (PE) is a pregnancy-specific disorder characterized by new-onset hypertension and proteinuria that occurs after 20 weeks of gestation. It involves several organs and continues to be a leading cause of maternal and perinatal morbidity and mortality worldwide. Shallow trophoblast invasion is a common pathological feature of PE. Transthyretin (TTR) is a 56-kDa homotetrameric protein that binds thyroid hormone and retinol binding protein. Dysregulated TTR expression has been found in cases of PE. The aim of the present study was to determine the functional role of TTR in the migration and invasion of JEG-3 choriocarcinoma cells...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28442058/nuclear-transfer-alters-placental-gene-expression-and-associated-histone-modifications-of-the-placental-specific-imprinted-gene-pleckstrin-homology-like-domain-family-a-member-2-phlda2-in-cattle
#2
Daniel R Arnold, Roberta C Gaspar, Carlos V da Rocha, Juliano R Sangalli, Tiago H C de Bem, Carolina A P Corrêa, João C T Penteado, Flavio V Meirelles, Flavia L Lopes
Abnormal placental development is frequent in nuclear transfer (NT) pregnancies and is likely to be associated with altered epigenetic reprogramming. In the present study, fetal and placental measurements were taken on Day 60 of gestation in cows with pregnancies produced by AI, IVF and NT. Placentas were collected and subjected to histological evaluation, the expression of genes important in trophoblast differentiation and expression of the placental imprinted gene pleckstrin homology-like domain, family A, member 2 (PHLDA2), as well as chromatin immunoprecipitation (ChIP) for histone marks within the promoter of PHLDA2...
March 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28428943/pathogenic-variant-in-nlrp7-19q13-42-associated-with-recurrent-gestational-trophoblastic-disease-data-from-early-embryo-development-observed-during-in-vitro-fertilization
#3
E Scott Sills, Alexandra J Obregon-Tito, Harry Gao, Thomas K McWilliams, Anthony T Gordon, Catharine A Adams, Rima Slim
OBJECTIVE: To describe in vitro development of human embryos derived from an individual with a homozygous pathogenic variant in NLRP7 (19q13.42) and recurrent hydatidiform mole (HM), an autosomal recessive condition thought to occur secondary to an oocyte defect. METHODS: A patient with five consecutive HM pregnancies was genomically evaluated via next generation sequencing followed by controlled ovarian hyperstimulation, in vitro fertilization (IVF) with intracytoplasmic sperm injection, embryo culture, and preimplantation genetic screening...
March 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28427089/editor-s-highlight-exposure-to-crvi-during-early-pregnancy-increases-oxidative-stress-and-disrupts-the-expression-of-antioxidant-proteins-in-placental-compartments
#4
Sakhila K Banu, Jone A Stanley, Kirthiram K Sivakumar, Robert J Taylor, Joe A Arosh, Robert C Burghardt
Epidemiologic studies document relationships between chromium VI (CrVI) exposure and increased risk of spontaneous abortion, stillbirth, preterm birth, and neonatal death in pregnant women. Environmental contamination with CrVI is a growing problem both in the United States and developing countries. CrVI is widely used in numerous industries. This study was designed to understand the mechanism of CrVI toxicity on placental oxidative stress and antioxidant (AOX) machinery. Pregnant mother rats were treated with or without CrVI (50 ppm K2Cr2O7) through drinking water from gestational day (GD) 9...
February 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28425063/blastocyst-derived-stem-cell-populations-under-stress-impact-of-nutrition-and-metabolism-on-stem-cell-potency-loss-and-miscarriage
#5
REVIEW
Yu Yang, Alan Bolnick, Alexandra Shamir, Mohammed Abdulhasan, Quanwen Li, G C Parker, Elizabeth E Puscheck, D A Rappolee
Data from in vitro and in vivo models suggest that malnutrition and stress trigger adaptive responses, leading to small for gestational age (SGA) blastocysts with fewer cell numbers. These stress responses are initially adaptive, but become maladaptive with increasing stress exposures. The common stress responses of the blastocyst-derived stem cells, pluripotent embryonic and multipotent placental trophoblast stem cells (ESCs and TSCs), are decreased growth and potency, and increased, imbalanced and irreversible differentiation...
April 19, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28420522/successful-treatment-of-gestational-trophoblastic-neoplasia-in-the-uterine-cornus-with-laparoscopic-cornuostomy-and-postoperative-methotrexate-injection
#6
Pei-Ling Chen, Jie-Yang Jhuang, Ho-Hsiung Lin, Sheng-Mou Hsiao
OBJECTIVE: Management of cornual gestational trophoblastic neoplasia (GTN) has never been reported. Here, we describe the first case of cornual GTN. CASE REPORT: A 32-year-old woman was diagnosed with left cornual GTN after evacuation of a complete mole. Laparoscopic cornuostomy was performed with intramural vasopression injection and barbed sutures. Histopathology revealed hydropic chorionic villi. Complete hydatidiform mole was diagnosed, and treated with adjuvant methotrexate, to address the poor decline of β-human chorionic gonadotropin levels during follow-up...
April 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28413543/primary-intracranial-choriocarcinoma-presenting-as-a-ring-enhancing-lesion-a-case-report-and-review-of-literature
#7
Mayur Sharma, Vernon Velho, Rachana Binayake, Chandranath Tiwari
We report here a rare case of primary intracranial choriocarcinoma without evidence of tumor elsewhere, presenting as a ring-enhancing lesion managed successfully in our institute (Grant Medical College and Sir J. J. Group of Hospitals, Mumbai, Maharashtra, India). A 22-year-old, right-handed housewife presented with complaints of headache, vomiting, generalized tonic-clonic seizures, and right upper limb weakness of short duration. On neurological examination, the patient was conscious, cooperative, well-oriented in time, place, and person...
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28411623/hemoptysis-as-primary-manifestation-in-three-women-with-choriocarcinoma-with-pulmonary-metastasis-a-case-series
#8
Wenping Zhang, Bao Liu, Jizhen Wu, Beibei Sun
BACKGROUND: Gestational choriocarcinoma is the most common gestational trophoblastic neoplasia; it is often secondary to hydatidiform mole, as well as to abortion, ectopic pregnancy, premature delivery, or term delivery. Approximately 60% of patients with choriocarcinoma develop pulmonary metastases, but for patients with a respiratory condition, choriocarcinoma with lung metastasis is a relatively rare lung cancer diagnosis. Three cases of choriocarcinoma with pulmonary metastasis who had the primary symptom of hemoptysis are described...
April 16, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28402512/defective-trophoblast-invasion-underlies-fetal-growth-restriction-and-pre-eclampsia-like-symptoms-in-the-stroke-prone-spontaneously-hypertensive-rat
#9
G Barrientos, M Pussetto, M Rose, A C Staff, S M Blois, J E Toblli
STUDY QUESTION: What is the impact of chronic hypertension on placental development, fetal growth and maternal outcome in the stroke-prone spontaneously hypertensive rat (SHRSP)? SUMMARY ANSWER: SHRSP showed an impaired remodeling of the spiral arteries and abnormal pattern of trophoblast invasion during placentation, which were associated with subsequent maternal glomerular injury and increased baseline hypertension as well as placental insufficiency and asymmetric fetal growth restriction...
April 11, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28401076/presentation-of-placental-site-trophoblastic-tumor-with-amenorrhea
#10
Fariba Behnamfar, Safoura Rouholamin, Mahboubeh Esteki
Placental site throphoblastic tumor (PSTT) is a rare manifestation of gestational trophoblastic neoplasia that may complicate any type of pregnancy. The disease is unique from other type, and is defined by slow growth, low human chorionic gonadotropin (hCG) serum levels, the late-onset metastatic potential, and most significantly, insensitivity to chemotherapy. We describe a case of a 31-year-old woman with prolonged amenorrhea and slightly elevated serum beta hCG (βhCG) level, referred for termination of abnormal pregnancy...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28394035/rapid-conceptus-elongation-in-the-pig-an-interleukin-1-beta-2-and-estrogen-regulated-phenomenon
#11
REVIEW
Rodney D Geisert, Jeffrey J Whyte, Ashley E Meyer, Daniel J Mathew, María R Juárez, Matthew C Lucy, Randall S Prather, Thomas E Spencer
Establishment and maintenance of pregnancy in the pig involves activating many physiological, cellular, and molecular signaling pathways between the developing conceptus and hormonally regulated maternal endometrium. Rapid elongation of the pig trophoblast allows for the establishment of sufficient placental surface area for the transport of nutrients to the fetus throughout pregnancy. Estrogens secreted by the conceptus during elongation act on uterine epithelia to induce secretion of uterine factors required for conceptus development and for preventing endocrine secretion of prostaglandin F2α, which would cause luteolysis...
April 10, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28390821/the-added-value-of-hysterectomy-in-the-management-of-gestational-trophoblastic-neoplasia
#12
Y K Eysbouts, L F A G Massuger, J IntHout, C A R Lok, F C G J Sweep, P B Ottevanger
BACKGROUND: Despite the undoubted effectiveness of chemotherapeutic treatment in gestational trophoblastic neoplasia (GTN), problems related to toxicity of chemotherapy and chemo-resistant disease have led to reconsideration of the use of hysterectomy. Aim of the present study was to evaluate indications for and outcome of hysterectomy in patients with GTN in a nation-wide cohort. METHODS: Between 1977 and 2012, we identified all patients diagnosed with GTN and treated with hysterectomy from the Dutch national databases...
April 5, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28382860/dysregulation-of-lncrnas-in-placenta-and-pathogenesis-of-preeclampsia
#13
Xuejing Song, Xiucui Luo, Quansheng Gao, Yuhuan Wang, Qing Gao, Wei Long
Preeclampsia, a gestational disease characterized by hypertension and proteinuria twenty weeks into pregnancy, is one of the leading causes of fetal and maternal mortality. Although multiple genetic and environmental factors are found to be related to the preeclampsia risk, the pathogenic pathways remain largely undefined. The placenta plays a critical role in the fetal development by carrying out the barrier, fetal-maternal exchange, and endocrine functions during pregnancy. Accumulated data indicated that the expression of multiple long noncoding RNA (LncRNA) is dysregulated in preeclamptic placentas...
April 4, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28381180/follow-up-of-gestational-trophoblastic-disease-neoplasia-via-quantification-of-circulating-nucleic-acids-of-placental-origin-using-c19mc-micrornas-hypermethylated-rassf1a-and-sry-sequences
#14
Ilona Hromadnikova, Katerina Kotlabova, Ladislav Krofta, Filip Hron
The aim of the study was to evaluate the effectiveness of placental-specific markers, extracellular fetal DNA (sex-determining region Y and hypermethylated RASSF1A sequences) and circulating C19MC microRNAs (miR-516-5p, miR-517-5p, miR-518b, miR-520a-5p, miR-520h, miR-525, and miR-526a) for the diagnosis and consecutive follow-up of gestational trophoblastic disease/neoplasia. Increased levels of extracellular fetal DNA and C19MC microRNAs were detected in patients with active disease when compared with the period when the patients reached remission of the disease...
April 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28380526/inhibition-of-chemokine-c-x-c-motif-receptor-four-cxcr4-at-the-fetal-maternal-interface-during-early-gestation-in-sheep-alterations-in-expression-of-chemokines-angiogenic-factors-and-their-receptors
#15
K E Quinn, S Z Prosser, K K Kane, R L Ashley
<p>Chemokine (C-X-C motif) ligand 12 (CXCL12) and its receptor, chemokine (C-X-C motif) receptor 4 (CXCR4), are involved in significant biological processes associated with early pregnancy including increasing trophoblast invasion and stimulating placental vascularization. To further elucidate functions of CXCL12-CXCR4 signaling during early gestation, our objective was to inhibit CXCR4 in vivo using a CXCR4 antagonist, AMD3100. We hypothesized that inhibition of CXCR4 would negatively affect chemokine and angiogenic factor regulation imperative for placental development in sheep...
March 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28380025/effect-of-proline-rich-15-deficiency-on-trophoblast-viability-and-survival
#16
Katherine C Gates, Lindsey N Goetzmann, Jeremy D Cantlon, Kimberly M Jeckel, Russell V Anthony
Deviations from the normal program of gene expression during early pregnancy can lead to early embryonic loss as well as dysfunctional placentation, which can cause significant morbidity and mortality. Proline rich 15 (PRR15) is a low molecular weight nuclear protein expressed by the trophoblast during early gestation. Lentivirus-mediated knockdown of PRR15 mRNA in ovine trophectoderm led to demise of the embryo by gestational day 15, providing compelling evidence that PRR15 expression is critical during this precarious window of development...
2017: PloS One
https://www.readbyqxmd.com/read/28379296/relaxin-treatment-reduces-angiotensin-ii-induced-vasoconstriction-in-pregnancy-and-protects-against-endothelial-dysfunction
#17
Sarah A Marshall, Chen Huei Leo, Jane E Girling, Marianne Tare, Sally Beard, Natalie J Hannan, Laura J Parry
The peptide relaxin has gained considerable attention as a new vasoactive drug, largely through its beneficial therapeutic effects in cardiovascular disease. In this study, we tested the hypothesis that relaxin treatment alleviates systemic vascular dysfunction characteristic of hypertensive diseases of pregnancy. We investigated vascular effects and mechanisms of relaxin action in: i) pregnant relaxin-deficient (Rln-/-) mice with enhanced responses to angiotensin II (AngII), and ii) arteries pre-incubated ex vivo in trophoblast conditioned media (TCM) to induce endothelial dysfunction...
April 3, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28377901/unusual-presentation-of-invasive-mole-a-case-report
#18
Soheila Aminimoghaddam, Andisheh Maghsoudnia
BACKGROUND: Invasive mole is responsible for most cases of localized gestational trophoblastic neoplasia. Gestational trophoblastic disease describes a number of gynecologic tumors that originate in trophoblastic layer including hydatidiform mole (complete or partial), invasive mole, choriocarcinoma, placental site trophoblastic tumor and epitheloid trophoblastic tumor. Invasive mole may arise from any pregnancy event although in most cases is diagnosed after molar pregnancy. Overall cure rate in low risk patients is nearly 100% and in high-risk patient 90%...
January 2017: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/28371633/ovarian-torsion-and-spontaneous-ovarian-hyperstimulation-syndrome-in-a-twin-pregnancy-a-case-report
#19
Núria Gil Navarro, Emma Garcia Grau, Sílvia Pina Pérez, Laia Ribot Luna
INTRODUCTION: Ovarian hyperstimulation syndrome (OHSS) is extremely rare in spontaneous pregnancies. Spontaneous OHSS can result from glycoprotein hormones stimulating follicle-stimulating hormone receptors (FSHR). PRESENTATION OF CASE: We report a twin pregnancy in which ovarian torsion and hemoperitoneum complicating OHSS were treated with left adnexectomy and aspiration. The only trigger for spontaneous OHSS in this case was high levels of chorionic gonadotropin hormone...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28369440/extravillous-trophoblast-invasion-of-venous-as-well-as-lymphatic-vessels-is-altered-in-idiopathic-recurrent-spontaneous-abortions
#20
Karin Windsperger, Sabine Dekan, Sophie Pils, Carsten Golletz, Victoria Kunihs, Christian Fiala, Glen Kristiansen, Martin Knöfler, Jürgen Pollheimer
STUDY QUESTION: Do extravillous trophoblasts (EVTs) invade non-arterial decidual vessels in healthy and pathological pregnancies? SUMMARY ANSWER: Our results reveal that trophoblast invasion of venous and lymphatic vessels is a frequent event during the first trimester of pregnancy and is compromised in  recurrent spontaneous abortion (RSA). In addition, the present data suggest that EVTs populate regional lymph nodes during pregnancy. WHAT IS ALREADY KNOWN: Human trophoblasts remodel and invade decidual spiral arteries...
March 28, 2017: Human Reproduction
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