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https://www.readbyqxmd.com/read/29777306/respiratory-manifestations-in-lps-responsive-beige-like-anchor-lrba-protein-deficient-patients
#1
Oded Shamriz, Bella Shadur, Adeeb NaserEddin, Irina Zaidman, Natalia Simanovsky, Orly Elpeleg, Eitan Kerem, Joel Reiter, Polina Stepensky
Lipopolysaccharide (LPS)-responsive beige-like anchor (LRBA) protein deficiency is a rare syndrome of primary immune deficiency and immune dysregulation. In this study, we sought to summarize our experience with respiratory manifestations in LRBA-deficient patients. We conducted a retrospective analysis of the medical records of LRBA-deficient patients treated at Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Data retrieved included pulmonary workup, disease course, treatment, and outcome. Ten patients were included...
May 18, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29776376/hybrid-surgery-in-treatment-of-pulmonary-sequestration-with-abdominal-aorta-feeding-vessel-a-case-report
#2
Haining Zhou, Shoujun Tang, Quanshui Fu, Li Yu, Lunxu Liu
BACKGROUND: Pulmonary sequestration is a rare congenital pulmonary dysplasia, which requires surgical resection (either via open thoracotomy or video-assisted thoracoscopic surgery [VATS] or via endoluminal occlusion of the abnormal feeding vessel). CASE PRESENTATION: We described a 51-year-old female patient with a history of recurrent cough and repeated pneumonia. She was referred to our hospital for further work-up of pulmonary sequestration. We performed a hybrid surgery (i...
May 18, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29768566/pulmonary-paracoccidioidomycosis-a-case-report-of-reactivation-in-a-patient-receiving-biological-therapy
#3
Lúcia Carla Polaco Covre, Pâmela Mazzini Hombre, Aloísio Falqueto, Paulo Mendes Peçanha, Valéria Valim
Paracoccidioidomycosis is an endemic disease in Latin America that is rarely associated with immunosuppression and biological therapy. Herein, we report for the first time a case of pulmonary paracoccidioidomycosis reactivation after infliximab treatment. A 47-year-old man from Brazil received infliximab to treat psoriatic spondyloarthropathy and presented with cough, dyspnea, weight loss, and fever. Chest computed tomography revealed a pulmonary nodule and biopsy confirmed paracoccidioidomycosis. Treatment with sulfamethoxazole and trimethoprim was initiated for fungal infection and infliximab was reintroduced two months later...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29768381/tuberculous-pleurisy-mimicking-mycoplasma-pneumoniae-infection-in-a-previously-healthy-young-adult-a-case-report
#4
Daizo Yaguchi, Motoshi Ichikawa, Masato Shizu, Noriko Inoue, Daisuke Kobayashi, Naoyuki Imai, Masao Ito
RATONALE: Sometimes, pleural effusion accompanying an acute Mycoplasma pneumoniae infection or tuberculous pleurisy has similar analysis results. We report a case of tuberculous pleurisy which was initially diagnosed as acute M pneumoniae infection, which is of special interest because anti-Mycoplasma antibody results were positive, which served as a red herring. PATIENT CONCERNS: A 20-year-old woman visited the outpatient emergency romm of our hospital for chief complaints of high fever, dry cough, and pleuralgia persiting for 2 days...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29768356/late-distant-recurrence-of-breast-carcinoma-and-metastasis-to-the-main-bronchus-and-choroid-a-case-report
#5
Zhijie Luo, Qin Cai, Yuanyuan Zhao, Xiaochuan Wang, Siying Fu, Linzhu Zhai
RATIONALE: Metastases of breast carcinoma to the main bronchus and choroid are rare, but have been reported in relevant literature. Late distant recurrence of breast carcinoma after more than 20 years is extremely rare. Herein, we report a 57-year-old woman with late distant recurrence and metastasis to the main bronchus and choroid almost 28 years after surgery. PATIENT CONCERNS: At the age of 29, the patient underwent chemotherapy and endocrine treatment after a right side mastectomy to remove breast carcinoma...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29768342/mucosa-associated-lymphoid-tissue-lymphoma-of-the-trachea-associated-with-idiopathic-pulmonary-fibrosis-a-case-report-and-literature-review
#6
June Hong Ahn, Jin Hong Chung, Kyeong-Cheol Shin, Eun Young Choi, Hyun Jung Jin, Joon Hyuk Choi, Kwan Ho Lee
RATIONALE: Mucosa-associated lymphoid tissue (MALT) lymphoma of the trachea is a rare disease that has been shown to be associated with chronic antigenic stimulation. There have been few reports of MALT lymphoma of the trachea in association with idiopathic pulmonary fibrosis (IPF). PATIENT CONCERNS: A 73-year-old patient visited with a 2-year history of dyspnea on exertion and productive cough, which had worsened 1 month ago. DIAGNOSES: MALT lymphoma of the trachea associated with IPF...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29767829/homeopathy-in-the-age-of-antimicrobial-resistance-is-it-a-viable-treatment-for-upper-respiratory-tract-infections
#7
Alison Fixsen
BACKGROUND:  Acute upper respiratory tract infections (URTIs) and their complications are the most frequent cause of antibiotic prescribing in primary care. With multi-resistant organisms proliferating, appropriate alternative treatments to these conditions are urgently required. Homeopathy presents one solution; however, there are many methods of homeopathic prescribing. This review of the literature considers firstly whether homeopathy offers a viable alternative therapeutic solution for acute URTIs and their complications, and secondly how such homeopathic intervention might take place...
May 2018: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/29767468/central-adenosine-a-1-receptors-inhibit-cough-via-suppression-of-excitatory-glutamatergic-and-tachykininergic-neurotransmission
#8
Ahmed Z El-Hashim, Seena Mathews, Fajer Al-Shamlan
BACKGROUND AND PURPOSE: The A1 adenosine receptor is reported to mediate several excitatory effects in the airways and has inhibitory effects in the central nervous system. In this study, we investigated the role of peripheral and central A1 adenosine receptors in regulating cough and airway obstruction. EXPERIMENTAL APPROACH: Drugs were administered to guinea pigs via the inhaled or intracerebroventricular (i.c.v.) routes. Cough was induced by exposing guinea pigs to aerosolised 0...
May 16, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29765618/mediastinal-monophasic-synovial-sarcoma-with-pericardial-extension-causing-hemodynamic-instability
#9
Habib R Khan, Mohammad I Ansari, Andrew P Thain, Sadia Abdullah, Ramya Parasa, Richard W Varcoe
A 46-year-old man presented with mass on chest x-ray along with a 6-month history of weight loss, dyspnea and cough. He was hypotensive and an echocardiogram showed large extra-cardiac mass compressing the right ventricular outflow tract resulting in features of cardiac tamponade. Chest computed tomography revealed a mediastinal mass invading the pericardium adjacent to right ventricular outflow tract. Biopsy of the mass confirmed primary monophasic synovial sarcoma. Chemotherapy and radiotherapy along with anti-inflammatories were given as surgery was too high risk due to the location of the tumour and pericardial involvement...
May 2018: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29764875/efficacy-and-safety-of-ghx02-in-the-treatment-of-acute-bronchitis-protocol-of-a-phase-ii-double-blind-randomised-placebo-controlled-trial
#10
Yee Ran Lyu, Won-Kyung Yang, So Jung Park, Seung-Hyeong Kim, Wee-Chang Kang, In Chul Jung, Yang Chun Park
INTRODUCTION: Acute bronchitis is a self-limiting infection of the large airways; cough is the primary symptom, usually lasting for about 3 weeks. Annually, approximately 5% of adults develop acute bronchitis, and its economic burden is substantial. There are also problems of antibiotic abuse in public health systems and symptomatic therapies are commonly prescribed, for which there is insufficient supporting evidence. GHX02 contains four herbs originating from gwaruhaengryeon-hwan, which has been used in the treatment of patients with acute bronchitis in Korea...
May 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29764014/-comprehensive-treatment-of-335-patients-with-pyriform-sinus-carcinoma-by-surgery-via-the-paraglottic-space-approach
#11
W M Li, D M Wei, Y Qian, S D Cao, Y Xu, D Y Liu, D P Lei, X L Pan
Objective: To report the experience in comprehensive surgical treatment of pyriform sinus carcinoma via the paraglottic space approach. Methods: Three hundred and thirty-five cases with pyriform sinus carcinoma (according to UICC 2012 criteria, stage Ⅰ, 12 cases; Ⅱ, 36; Ⅲ, 79; Ⅳ, 208; T1, 26; T2, 139; T3, 121; T4, 49; cN0, 83; cN1, 61; cN2a-b, 118; cN2c, 71; cN3, 2) treated between 2006 and 2013 were retrospectively reviewed. There were 323 males and 12 females. Age aged from 36 to 80 years old with a median of 60 years old...
May 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29762255/ombitasvir-paritaprevir-ritonavir-dasabuvir-ribavirin-for-chronic-hepatitis-c-virus-genotype-1b-infected-cirrhotics-turquoise-iv
#12
Vasily Isakov, Dzmitry Paduta, Rolando M Viani, Jeffrey V Enejosa, Viktor Pasechnikov, Olga Znoyko, Pavel Ogurtsov, Pavel O Bogomolov, Marina V Maevskaya, Xiaotian Chen, Nancy S Shulman
OBJECTIVE: An estimated 336 per 100 000 people in Russia are infected with hepatitis C virus, including up to 75% with genotype (GT) 1b. In the TURQUOISE-II/-III trials, a 12-week regimen of the direct-acting antiviral agents ombitasvir (OBV), paritaprevir (PTV), ritonavir, and dasabuvir (DSV) in GT1b-infected patients with compensated cirrhosis resulted in 12-week sustained virologic response (SVR) rates of 100%. PATIENTS AND METHODS: In TURQUOISE-IV, GT1b-infected patients (n=36) from Russia and Belarus with compensated cirrhosis, who were treatment naive or previously treated with pegylated interferon/ribavirin (RBV), received OBV/PTV/ritonavir+DSV+RBV for 12 weeks...
May 14, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29756719/-pulmonary-hypertension-associated-with-the-human-immunodeficiency-virus-in-children-treatment-with-sildenafil-a-case-report
#13
Carolina Stepffer, Evelyn Gaynor, Mariela López, Norma E González, Micaela Arri, Ana Ms De Dios
Pulmonary hypertension associated with human immunodeficiency virus infection is an extremely rare disease in pediatrics; it requires a high clinical suspicion to reach a diagnosis. Its appearance poses an unfavorable prognostic, but early diagnosis and specific treatment can improve outcomes. We report the clinical case of a fifteen-year-old patient diagnosed with human immunodeficiency virus infection of vertical transmission, without antiretroviral treatment, with cough and progressive exertional dyspnea, associated with signs of right heart failure in which severe pulmonary hypertension was diagnosed...
June 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29755760/impact-of-measles-supplementary-immunisation-activities-on-utilisation-of-maternal-and-child-health-services-in-low-income-and-middle-income-countries
#14
Iryna Postolovska, Stéphane Helleringer, Margaret E Kruk, Stéphane Verguet
Background: Measles supplementary immunisation activities (SIAs) are an integral component of measles elimination in low-income and middle-income countries (LMICs). Despite their success in increasing vaccination coverage, there are concerns about their negative consequences on routine services. Few studies have conducted quantitative assessments of SIA impact on utilisation of health services. Methods: We analysed the impact of SIAs on utilisation of selected maternal and child health services using Demographic and Health Surveys and Multiple Indicator Cluster Surveys from 28 LMICs, where at least one SIA occurred over 2000-2014...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29755029/a-double-blind-placebo-controlled-trial-of-fennel-foeniculum-vulgare-on-menopausal-symptoms-a-high-placebo-response
#15
Masumeh Ghazanfarpour, Mona Najaf Najafi, Nosrat Baharian Sharghi, Mahsa Sadat Mousavi, Masoudeh Babakhanian, Hassan Rakhshanded
OBJECTIVE: The present study aimed to evaluate the oral fennel effects on the menopausal symptoms. MATERIAL AND METHODS: This double-blind, randomized, placebo-controlled trial was conducted on fifty postmenopausal women in Mashhad (Iran). Patients randomly divided into two groups of fennel ( n = 25) and placebo ( n= 25). The measurements were carried out at the baseline and after three months through Menopause-Specific Quality of Life (MENQOL) questionnaire. RESULTS: Both placebo and treatment groups revealed significant improvement in the hot flush score ( p< 0...
May 14, 2018: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29750825/cyclamen-europaeum-extract-for-acute-sinusitis
#16
REVIEW
Anca Zalmanovici Trestioreanu, Ankur Barua, Barak Pertzov
BACKGROUND: Acute sinusitis is a common reason for primary care encounters. It causes significant symptoms including facial pain, congested nose, headache, thick nasal mucus, fever, and cough and often results in time off work or school. Sinusitis treatment focuses on eliminating causative factors and controlling the inflammatory and infectious components. The frozen, dried, natural fluid extract of the Cyclamen europaeum plant delivered intranasally is thought to have beneficial effects in relieving congestion by facilitating nasal drainage, and has an anti-inflammatory effect...
May 11, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29749991/pulmonary-embolism-as-a-rare-complication-of-liver-hydatid-cyst-report-of-two-cases
#17
Omar Toumi, Randa Salem, Sadok Ben Jabra, Ghedira Abdesslem, Faouzi Noomen, Abdel Aziz Hamdi
Hydatid cyst is a helminth infection. The rupture of a hepatic hydatid cyst in inferior vena cava is a rare and lethal complication. Pulmonary embolism is the commonest manifestation. The diagnosis of hydatid cyst is made by histopathological or serological examination, and imaging may suggest the probability of hydatid cyst. Surgical treatment should be performed with caution and always under vascular control. We present two cases of hydatid cyst ruptured into the inferior vena cava. The patients also presented with dyspnea, hemoptysis, and intermittent cough at the time of admission...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29748881/anti-inflammatory-effects-of-ivy-leaves-dry-extract-influence-on-transcriptional-activity-of-nf%C3%AE%C2%BAb
#18
Janka Schulte-Michels, Christina Keksel, Hanns Häberlein, Sebastian Franken
EA 575® is an ivy leaves dry extract (DER 5-7.5:1, 30% ethanol) used against diseases of the lower respiratory tract associated with productive cough. EA 575® improves symptoms associated with chronic inflammatory bronchial conditions. Compared to its bronchospasmolytic and secretolytic properties, the anti-inflammatory effects of EA 575® are mostly untried. Therefore, we addressed the question of whether the anti-inflammatory effect of EA 575® is due to an impact on the NFκB pathway. NFκB nuclear translocation was visualized by immunofluorescence in J774...
May 11, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29745038/intralobar-pulmonary-sequestration-originating-from-the-intercostal-arteries-treated-with-surgical-resection
#19
Xin Li, Hui Du, Mujeeb Ur Rehman, Ming Dong, Minghui Liu, Hongyu Liu, Jun Chen
Intralobar pulmonary sequestration originating from the intercostal arteries is rarely reported. Herein, we report an unusual case of a 56-year-old male patient with intralobar pulmonary sequestration supplied from the intercostal arteries on the left lower lobe who presented after a month of a repeated cough and massive hemoptysis. Although transcatheter arterial embolization was performed three times, the patient's symptoms were not relieved. A left lower lobectomy was performed with video-assisted thoracic surgery...
May 9, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29744229/alk-positive-squamous-cell-carcinoma-dramatically-responded-to-alectinib
#20
Ray Sagawa, Takehiko Ohba, Eisaku Ito, Susumu Isogai
Anaplastic lymphoma kinase (ALK) rearrangement is usually observed in patients with adenocarcinoma. Herein, we report a case of squamous cell carcinoma (SCC) with ALK rearrangement treated with alectinib. The patient was a 73-year-old woman without a smoking history. She consulted us with nonproductive cough and loss of appetite. Computed tomography scan revealed a mass in the left lower lobe of the lung. According to the pathological examinations, we diagnosed the tumor as SCC. Because the patient had never smoked, we searched for driver mutations and found that the tumor harbored ALK rearrangement...
2018: Case Reports in Oncological Medicine
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