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https://www.readbyqxmd.com/read/27936280/application-of-the-combined-fibrometer-vcte-algorithm-in-chinese-patients-with-nonalcoholic-fatty-liver-disease
#1
Thomson Chi-Wang Loong, Jeremy Lok Wei, Jonathan Chung-Fai Leung, Grace Lai-Hung Wong, Sally She-Ting Shu, Angel Mei-Ling Chim, Anthony Wing-Hung Chan, Paul Cheung-Lung Choi, Yee-Kit Tse, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong
BACKGROUND AND AIM: The FM VCTE is a new formula combining the serum test FibroMeter (FM) and liver stiffness measurement (LSM) by vibration controlled transient elastography (VCTE). We tested the accuracy and utility of FM VCTE for fibrosis staging in patients with non-alcoholic fatty liver disease (NAFLD). METHODS: 215 NAFLD patients with LSM, FM NAFLD, FM VCTE and other serum tests (aspartate aminotransferase [AST]-to-platelet ratio index, FIB-4 index, BARD score, NAFLD fibrosis score and AST-to-alanine aminotransferase ratio) performed 1 day before liver biopsy were evaluated...
December 9, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27936141/hbs-binding-to-gp1b%C3%AE-activates-platelets-in-sickle-cell-disease
#2
Gowtham K Annarapu, Rashi Singhal, Avinash Gupta, Sheetal Chawla, Harish Batra, Tulika Seth, Prasenjit Guchhait
Intravascular hemolysis increases the risk of thrombosis in hemolytic disorders. Our previous study showed that the binding of adult hemoglobin (HbA) to glycoprotein (GP) 1bα induced the activation of platelets. The elevated plasma Hb or platelet surface bound Hb positively correlated with platelet activation in patients with paroxysmal nocturnal hemoglobinuria (PNH). Furthermore, this study shows that the sickle Hb [HbS, occurs due to single nucleotide polymorphism at A>T of β-globin gene of Hb and causes sickle cell disease (SCD)] also bound to GP1bα and activated platelets in a concentration-dependent manner...
2016: PloS One
https://www.readbyqxmd.com/read/27936091/development-of-serum-marker-models-to-increase-diagnostic-accuracy-of-advanced-fibrosis-in-nonalcoholic-fatty-liver-disease-the-new-linki-algorithm-compared-with-established-algorithms
#3
Byron Lykiardopoulos, Hannes Hagström, Mats Fredrikson, Simone Ignatova, Per Stål, Rolf Hultcrantz, Mattias Ekstedt, Stergios Kechagias
BACKGROUND AND AIM: Detection of advanced fibrosis (F3-F4) in nonalcoholic fatty liver disease (NAFLD) is important for ascertaining prognosis. Serum markers have been proposed as alternatives to biopsy. We attempted to develop a novel algorithm for detection of advanced fibrosis based on a more efficient combination of serological markers and to compare this with established algorithms. METHODS: We included 158 patients with biopsy-proven NAFLD. Of these, 38 had advanced fibrosis...
2016: PloS One
https://www.readbyqxmd.com/read/27936002/the-significance-of-prolonged-and-saddleback-fever-in-hospitalised-adult-dengue
#4
Deborah Hl Ng, Joshua Gx Wong, Tun-Linn Thein, Yee-Sin Leo, David C Lye
Dengue fever is gaining importance in Singapore with an increase in the number of cases and mortality in recent years. Although prolonged and saddleback fever have been reported in dengue fever, there are no specific studies on their significance in dengue. This study aims to examine the prevalence of prolonged and saddleback fever in dengue as well as their associations with dengue severity. A total of 2843 polymerase-chain reaction (PCR) confirmed dengue patients admitted to Tan Tock Seng Hospital from 2004 to 2008 were included in the study...
2016: PloS One
https://www.readbyqxmd.com/read/27935954/normal-wound-healing-and-tumor-angiogenesis-as-a-game-of-competitive-inhibition
#5
Irina Kareva, Abdo Abou-Slaybi, Oliver Dodd, Olga Dashevsky, Giannoula Lakka Klement
Both normal wound healing and tumor angiogenesis are mitigated by the sequential, carefully orchestrated release of growth stimulators and inhibitors. These regulators are released from platelet clots formed at the sites of activated endothelium in a temporally and spatially controlled manner, and the order of their release depends on their affinity to glycosaminoglycans (GAG) such as heparan sulfate (HS) within the extracellular matrix, and platelet open canallicular system. The formation of vessel sprouts, triggered by angiogenesis regulating factors with lowest affinities for heparan sulfate (e...
2016: PloS One
https://www.readbyqxmd.com/read/27935917/safety-and-efficacy-of-azathioprine-as-a-second-line-therapy-for-primary-immune-thrombocytopenic-purpura
#6
B S Poudyal, B Sapkota, G S Shrestha, S Thapalia, B Gyawali, S Tuladhar
INTRODUCTION: Immune thrombocytopenic purpura remains common blood disease in Nepal. Azathioprine is an oral immunosupressive medicine which has been used widely in various autoimmune disease and solid organ transplant patients. It is inexpensive, easily available and well tolerated medicine. This study was carried out to evaluate efficacy and safety of azathioprine as a second line medicine for primary ITP patients who were refractory to steroid therapy. METHODS: The observational, pre-post study was conducted at Government of Nepal Civil Service Hospital, Kathmandu from January to October 2014...
July 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27935899/-algorithm-for-selection-of-individual-therapy-with-clopidogrel-in-vascular-surgical-practice
#7
A I Shevela, A A Slepukhina, E M Zelenskaya, T A Seredina, G I Lifshits
For treatment of patients with diseases of lower limb arteries and prevention of cardiovascular complications in high-risk patients (those with diabetes mellitus, arterial hypertension, dyslipidemia, obesity) permanent antiplatelet therapy is indicated. A problem is variable individual sensitivity to therapeutic agents. For antiplatelet therapy in patients with atherosclerosis of lower limb arteries there has been obtained an evidence-supported base concerning efficacy of long-term administration of clopidogrel preparations, unlike patients with acute coronary syndrome, for whom there has been accumulated an evidence-confirmed base of administering clopidogrel preparations, as well as ticagrelor and prasugrel in various clinical situations...
2016: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/27935865/bronchial-airway-gene-expression-signatures-in-mouse-lung-squamous-cell-carcinoma-and-their-modulation-by-cancer-chemopreventive-agents
#8
Donghai Xiong, Jing Pan, Qi Zhang, Eva Szabo, Mark Steven Miller, Ronald A Lubet, Ming You, Yian Wang
Due to exposure to environmental toxicants, a "field cancerization" effect occurs in the lung resulting in the development of a field of initiated but morphologically normal appearing cells in the damaged epithelium of bronchial airways with dysregulated gene expression patterns. Using a mouse model of lung squamous cell carcinoma (SCC), we performed transcriptome sequencing (RNA-Seq) to profile bronchial airway gene expression and found activation of the PI3K and Myc signaling networks in cytologically normal bronchial airway epithelial cells of mice with preneopastic lung SCC lesions, which was reversed by treatment with the PI3K Inhibitor XL-147 and pioglitazone, respectively...
December 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27935296/graphene-montmorillonite-composite-sponge-for-safe-and-effective-hemostasis
#9
Guofeng Li, Kecheng Quan, Yuping Liang, Tianyi Li, Qipeng Yuan, Lei Tao, Qian Xie, Xing Wang
Montmorillonite (MMT) is considered to be the most effective hemostat among natural phyllosilicates. However, there is a barrier against using MMT for the commercial hemostatics because the invaded MMT powders might cause thrombosis in vessel. Till now, it is still a challenge to manage the release of MMT and eliminate its side effect. Herein, we present a graphene-MMT composite sponge (GMCS), synthesized under a hydrothermal reaction, fixing MMT powders into the cross-linked graphene sheets. We demonstrate that only a few embedded MMT can evoke remarkable platelet stimulation at the sponge interface, while maintaining fast plasma absorbency of the innate sponge...
December 9, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27935212/hemophilia-liver-transplantation-observational-study-hots
#10
Margaret V Ragni, Abhinav Humar, Peter G Stock, Emily A Blumberg, Bijan Eghtesad, John J Fung, Valentina Stosor, Nicholas Nissen, Michael T Wong, Kenneth E Sherman, Donald M Stablein, Burc Barin
: Hepatitis C (HCV) infection is the leading cause of liver disease in hemophilia. In those with HIV/HCV co-infection, the rate of liver disease progression is greater than in HCV mono-infected individuals. Despite antiretroviral therapy which slows HCV liver disease progression, some require transplantation. Whether transplant outcomes are worse in hemophilic (H) than non-hemophilic (NH) candidates is unknown. In order to determine rates and predictors of pre- and post-transplant survival, we conducted a retrospective observational study utilizing United Network for Organ Sharing (UNOS) national transplant registry data, comparing HCV+ H and NH candidates...
December 9, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27935168/effectiveness-and-safety-of-sofosbuvir-based-regimens-plus-an-ns5a-inhibitor-for-patients-with-hcv-genotype-3-infection-and-cirrhosis-results-of-a-multicenter-real-life-cohort
#11
S Alonso, M Riveiro-Barciela, I Fernandez, D Rincón, Y Real, S Llerena, F Gea, A Olveira, C Fernandez-Carrillo, B Polo, J A Carrión, A Gómez, M J Devesa, C Baliellas, Á Castro, J Ampuero, R Granados, J M Pascasio, A Rubín, J Salmeron, E Badia, J M M Planas, S Lens, J Turnes, J L Montero, M Buti, R Esteban, C M Fernández-Rodríguez
Patients with HCV genotype 3 (GT3) infection and cirrhosis are currently the most difficult to cure. We report our experience with sofosbuvir+daclatasvir (SOF+DCV) or sofosbuvir/ledipasvir (SOF/LDV), with or without ribavirin (RBV) in clinical practice in this population. This was a multicenter observational study including cirrhotic patients infected by HCV GT3, treated with sofosbuvir plus an NS5A inhibitor (May 2014-October 2015). In total, 208 patients were included: 98 (47%) treatment-experienced, 42 (20%) decompensated and 55 (27%) MELD score >10...
December 9, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27935164/kaolin-activated-thromboelastography-and-standard-coagulation-assays-in-cyanotic-and-acyanotic-infants-undergoing-complex-cardiac-surgery-a-prospective-cohort-study
#12
Alessandra Rizza, Zaccaria Ricci, Chiara Pezzella, Isabella Favia, Giovina Di Felice, Marco Ranucci, Paola Cogo
BACKGROUND AND AIMS: Several studies report the use of thromboelatography (TEG) to monitor coagulation in pediatric cardiac surgery. The aim of this study was to compare baseline and intraoperative TEG, TEG-functional fibrinogen, and standard coagulation assays in children with cyanotic and acyanotic congenital heart disease (CHD) undergoing cardiac surgery. METHODS: This is a prospective observational study of 63 children aged <24 months undergoing cardiac surgery with cardiopulmonary bypass (CPB)...
December 9, 2016: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/27935090/clinical-utility-of-closure-times-using-the-platelet-function-analyzer-pfa-100-200
#13
Emmanuel J Favaloro
The 'platelet function analyzer' (PFA)-100 was first introduced to us in 1995. Since then, the instrument has appeared in over 50 reviews and almost 1000 publications. Recently, the PFA-100 has been 'upgraded' to the PFA-200, which has transformed the user interface and electronic management, but retained the fundamental mechanics, and essentially provides the same results. The PFA-100/200 has conceivable clinical utility to screen for von Willebrand Disease (VWD) and platelet disorders, and in monitoring desmopressin (DDAVP) therapy in both, and possibly anti-platelet therapy...
December 9, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27934923/timosaponin-aiii-induces-antiplatelet-and-antithrombotic-activity-via-gq-mediated-signaling-by-the-thromboxane-a2-receptor
#14
Yue Cong, Limei Wang, Renjun Peng, Yang Zhao, Fan Bai, Chao Yang, Xiaolan Liu, Daqian Wang, Baiping Ma, Yuwen Cong
The thromboxane (Tx) A2 pathway is a major contributor to the amplification of initial platelet activation and is therefore a key drug target. To identify potent small-molecule inhibitors of the thromboxane prostaglandin (TP) receptor, we screened a small steroidal saponin library using U46619-induced rat platelet aggregation assays. Timosaponin AIII (TAIII) was identified as a potent inhibitor of U46619-induced rat platelet aggregation and exhibited superior selectivity for the TP receptor versus other G protein-coupled receptors and a PKC activator...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27934591/generation-of-a-human-induced-pluripotent-stem-cell-ipsc-line-from-a-bernard-soulier-syndrome-patient-with-the-mutation-p-asn45ser-in-the-gpix-gene
#15
Lourdes Lopez-Onieva, Candela Machuca, Mar Lamolda, Rosa Montes, Maria Luisa Lozano, Vicente Vicente, José Rivera, Verónica Ramos-Mejía, Pedro J Real
Bernard Soulier Syndrome (BSS) is an inherited rare platelet disorder characterized by mutations in the platelet glycoprotein complex GPIb-IX-V. We generated an induced pluripotent stem cell (iPSC) line from a BSS patient with a mutation p.Asn45Ser in the GPIX locus (BSS2-PBMC-iPS4F24). Peripheral blood mononuclear cells were reprogrammed using non-integrative viral transduction. Characterization of BSS2-PBMC-iPS4F24 included mutational analysis of GPIX locus, analysis of conventional pluripotency-associated factors at mRNA and protein level and in vitro and in vivo differentiation studies...
November 8, 2016: Stem Cell Research
https://www.readbyqxmd.com/read/27934233/modeling-membrane-protein-ligand-binding-interactions-the-human-purinergic-platelet-receptor
#16
D'Artagnan Greene, Wesley M Botello-Smith, Alec Follmer, Li Xiao, Eleftherios Lambros, Ray Luo
Membrane proteins, due to their roles as cell receptors and signaling mediators, make prime candidates for drug targets. The computational analysis of protein-ligand binding affinities has been widely employed as a tool in rational drug design efforts. Although efficient implicit solvent-based methods for modeling globular protein-ligand binding have been around for many years, the extension of such methods to membrane protein-ligand binding is still in its infancy. In this study, we extended the widely used Amber/MMPBSA method to model membrane protein-ligand systems, and we used it to analyze protein-ligand binding for the human purinergic platelet receptor (P2Y12R), a prominent drug target in the inhibition of platelet aggregation for the prevention of myocardial infarction and stroke...
December 8, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/27934188/nanostructured-montmorillonite-clay-for-controlling-the-lipase-mediated-digestion-of-medium-chain-triglycerides
#17
Tahnee J Dening, Paul Joyce, Shasha Rao, Nicky Thomas, Clive A Prestidge
Biocompatible lipid hybrid particles composed of montmorillonite and medium chain triglycerides were engineered for the first time by spray drying oil-in-water emulsions stabilized by montmorillonite platelets to form montmorillonite-lipid hybrid (MLH) microparticles containing up to 75% w/w lipid. In vitro lipolysis studies under simulated intestinal conditions indicated that the specific porous nanoarchitecture and surface chemistry of MLH particles significantly increased the rate (>10-fold) and extent of lipase-mediated digestion compared to that of coarse and homogenized submicrometer triglyceride emulsions...
December 7, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27933817/peptide-mediated-platelet-capture-at-gold-micropore-arrays
#18
Kellie Adamson, Elaine Spain, Una Prendergast, Niamh Moran, Robert J Forster, Tia E Keyes
Ordered spherical cap gold cavity arrays with 5.4, 1.6, and 0.98 μm diameter apertures were explored as capture surfaces for human blood platelets to investigate the impact of surface geometry and chemical modification on platelet capture efficiency and their potential as platforms for surface enhanced Raman spectroscopy of single platelets. The substrates were chemically modified with single-constituent self-assembled monolayers (SAM) or mixed SAMs comprised of thiol-functionalized arginine-glycine-aspartic acid (RGD, a platelet integrin target) with or without 1-octanethiol (adhesion inhibitor)...
November 30, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27933336/shp-1-activation-inhibits-vascular-smooth-muscle-cell-proliferation-and-intimal-hyperplasia-in-a-rodent-model-of-insulin-resistance-and-diabetes
#19
Weier Qi, Qian Li, Chong Wee Liew, Christian Rask-Madsen, Samuel M Lockhart, Lars Melholt Rasmussen, Yu Xia, Xuanchun Wang, Mogher Khamaisi, Kevin Croce, George L King
AIMS/HYPOTHESIS: Accelerated migration and proliferation of vascular smooth muscle cells (VSMCs) enhances arterial restenosis after angioplasty in insulin resistance and diabetes. Elevation of Src homology 2-containing protein tyrosine phosphatase 1 (SHP-1) induces apoptosis in the microvasculature. However, the role of SHP-1 in intimal hyperplasia and restenosis has not been clarified in insulin resistance and diabetes. METHODS: We used a femoral artery wire injury mouse model, rodent models with insulin resistance and diabetes, and patients with type 2 diabetes...
December 9, 2016: Diabetologia
https://www.readbyqxmd.com/read/27933268/autologous-platelet-lysates-local-injections-for-treatment-of-tibia-non-union-with-breakage-of-the-nickelclad-a-case-report
#20
Hong-Jiang Jiang, Xun-Xiang Tan, Hai-Yang Ju, Jin-Ping Su, Wei Yan, Xiu-Gang Song, Li-Wu Qin, Chang-Jun Ju, Ling-Shuang Wang, De-Bao Zou
BACKGROUND: Nonunions of the tibia represent challenging orthopedic problems, which require the surgeon to analyze numerous factors and choose an appropriate treatment. This article presents a case report of tibia and fibula fracture patient who failed the internal fixation surgery and successfully recovered after one course of percutaneous autologous platelet lysates injection. CASE DESCRIPTION: The patient received an internal nickelclad breakage at 9 months post-surgery but reluctant to accept a second surgery, then autologous platelet lysates (APL) injection which is a less invasive method was recommended...
2016: SpringerPlus
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