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https://www.readbyqxmd.com/read/28325089/the-need-to-develop-a-patient-centered-precision-medicine-model-for-adults-with-chronic-disability
#1
Susan M Wolf, Bharat Thyagarajan, Brent L Fogel
No abstract text is available yet for this article.
March 22, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28281411/abnormalities-in-serum-biomarkers-correlate-with-lower-cardiac-index-in-the-fontan-population
#2
MULTICENTER STUDY
Bradley S Marino, David J Goldberg, Adam L Dorfman, Eileen King, Heidi Kalkwarf, Babette S Zemel, Margaret Smith, Jesse Pratt, Mark A Fogel, Amanda J Shillingford, Barbara J Deal, Anitha S John, Caren S Goldberg, Timothy M Hoffman, Marshall L Jacobs, Asher Lisec, Susan Finan, Lazaros K Kochilas, Thomas W Pawlowski, Kathleen Campbell, Clinton Joiner, Stuart L Goldstein, Paul Stephens, Alvin J Chin
BACKGROUND: Fontan survivors have depressed cardiac index that worsens over time. Serum biomarker measurement is minimally invasive, rapid, widely available, and may be useful for serial monitoring. The purpose of this study was to identify biomarkers that correlate with lower cardiac index in Fontan patients. Methods and results This study was a multi-centre case series assessing the correlations between biomarkers and cardiac magnetic resonance-derived cardiac index in Fontan patients ⩾6 years of age with biochemical and haematopoietic biomarkers obtained ±12 months from cardiac magnetic resonance...
January 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28278391/blood-eosinophils-and-response-to-maintenance-copd-treatment-data-from-the-flame-trial
#3
Nicolas Roche, Kenneth R Chapman, Claus F Vogelmeier, Felix J F Herth, Chau Thach, Robert Fogel, Petter Olsson, Francesco Patalano, Donald Banerji, Jadwiga A Wedzicha
RATIONALE: Post-hoc analyses suggest that blood eosinophils have potential as a predictive biomarker of inhaled corticosteroid efficacy in the management of chronic obstructive pulmonary disease. OBJECTIVES: We prospectively investigated the value of blood eosinophils as a predictor of responsiveness to an inhaled corticosteroid/long-acting β2-agonist combination versus a long-acting β2-agonist/long-acting muscarinic antagonist combination for exacerbation prevention...
March 9, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28277487/a-randomized-controlled-trial-of-an-intervention-to-maintain-suppression-of-hiv-viremia-following-prison-release-the-impact-trial
#4
David Alain Wohl, Carol E Golin, Kevin Knight, Michele Gould, Jessica Carda-Auten, Jennifer S Groves, Sonia Napravnik, Stephen R Cole, Becky L White, Cathie Fogel, David L Rosen, Michael J Mugavaro, Brian W Pence, Patrick M Flynn
BACKGROUND: HIV-infected individuals transitioning from incarceration to the community are at risk for loss of viral suppression. We compared the effects of imPACT, a multi-dimensional intervention to promote care engagement after release, to standard care on sustaining viral suppression after community re-entry. METHODS: This trial randomized 405 HIV-infected inmates being released from prisons in Texas and North Carolina with HIV-1 RNA levels <400 copies/mL to imPACT versus standard care...
March 8, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28249626/association-between-an-ectoparasitic-copepod-caligus-sp-and-the-monogenean-udonella-cf-caligorum-johnston-1835-on-a-catfish-population
#5
D Fogel, J L Fuentes, L M Soto, C López
We analysed the association between a monogenean (Udonella cf. caligorum Johnston 1835) and its copepod host (Caligus sp.) living on a wild population of Arius herzbergii Bloch, 1794 in a north-eastern coastal lagoon from Venezuela. This study characterized infestation levels and analysed the effects of monogeneans on the fecundity and hatching success of the copepod host, as well as damage to its egg capsules and genital complex. A total of 218 Caligus specimens were analysed (94 males, 110 females and 14 immature stages) in which a total of 1017 monogeneans were found...
March 2, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28226278/quantitative-methylene-blue-decolourisation-assays-as-rapid-screening-tools-for-assessing-the-efficiency-of-catalytic-reactions
#6
Jan Kruid, Ronen Fogel, Janice Leigh Limson
Identifying the most efficient oxidation process to achieve maximum removal of a target pollutant compound forms the subject of much research. There exists a need to develop rapid screening tools to support research in this area. In this work we report on the development of a quantitative assay as a means for identifying catalysts capable of decolourising methylene blue through the generation of oxidising species from hydrogen peroxide. Here, a previously described methylene blue test strip method was repurposed as a quantitative, aqueous-based spectrophotometric assay...
May 2017: Chemosphere
https://www.readbyqxmd.com/read/28213204/a-description-of-an-obesogenic-eating-style-that-promotes-higher-energy-intake-and-is-associated-with-greater-adiposity-in-4-5year-old-children-results-from-the-gusto-cohort
#7
Anna Fogel, Ai Ting Goh, Lisa R Fries, Suresh Anand Sadananthan, S S Velan, Navin Michael, Mya Thway Tint, Marielle Valerie Fortier, Mei Jun Chan, Jia Ying Toh, Yap-Seng Chong, Kok Hian Tan, Fabian Yap, Lynette P Shek, Michael J Meaney, Birit F P Broekman, Yung Seng Lee, Keith M Godfrey, Mary Foong Fong Chong, Ciarán G Forde
Recent findings confirm that faster eating rates support higher energy intakes within a meal and are associated with increased body weight and adiposity in children. The current study sought to identify the eating behaviours that underpin faster eating rates and energy intake in children, and to investigate their variations by weight status and other individual differences. Children (N=386) from the Growing Up in Singapore towards Healthy Outcomes (GUSTO) cohort took part in a video-recorded ad libitum lunch at 4...
February 14, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28201840/clinical-response-to-dorsal-duct-drainage-via-the-minor-papilla-in-refractory-obstructing-chronic-calcific-pancreatitis
#8
Chang-Il Kwon, Mark A Gromski, Stuart Sherman, Ihab I El Hajj, Jeffrey J Easler, James Watkins, Lee McHenry, Glen A Lehman, Evan L Fogel
Background and study aims Complete stone removal from the main pancreatic duct might not be achieved in all patients with obstructive chronic calcific pancreatitis. We report our results for endoscopic dorsal pancreatic duct (DPD) bypass of obstructing stones in the ventral pancreatic duct (VPD). Patients and methods 16 patients with obstructive chronic calcific pancreatitis were treated with a DPD bypass. Clinical success was defined as significant pain relief and no hospital admissions for pain management during the ongoing treatment period...
February 15, 2017: Endoscopy
https://www.readbyqxmd.com/read/28198781/biomechanical-analysis-of-two-level-cervical-disc-replacement-with-a-stand-alone-u-shaped-disc-implant
#9
Yang Li, Guy R Fogel, Zhenhua Liao, Rajnesh Tyagi, Gaolong Zhang, Weiqiang Liu
STUDY DESIGN: Biomechanical study using a three-dimensional nonlinear finite element (FE) model. OBJECTIVE: To analyze biomechanical changes with three prostheses based on two-level arthroplasty and to verify the biomechanical efficiency of dynamic cervical implants (DCIs) with a stand-alone U-shaped structure. SUMMARY OF BACKGROUND DATA: Few studies have compared biomechanical behavior of various prostheses as they relate to clinical results after two-level total disc replacement (TDR)...
February 14, 2017: Spine
https://www.readbyqxmd.com/read/28193535/the-utility-of-nurse-managed-extracorporeal-life-support-in-an-adult%C3%A2-cardiac-intensive-care-unit
#10
Amy E Hackmann, Luke M Wiggins, Glenn P Grimes, Richard M Fogel, Felicia A Schenkel, Mark L Barr, Michael E Bowdish, Mark J Cunningham, Vaughn A Starnes
BACKGROUND: The use of extracorporeal life support (ECLS) worldwide has increased exponentially since 2009. The patient requiring ECLS demands an investment of hospital resources, including personnel. Educating bedside nurses to manage ECLS circuits broadens the availability of trained providers. METHODS: Experienced cardiothoracic intensive care unit (CTICU) nurses underwent training to manage ECLS circuits, including volume assessment, treatment of arterial blood gas values, the physiology of ECLS, and recognition of common emergencies...
February 10, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28178074/a-common-pro-nociceptive-pain-modulation-profile-typifying-subgroups-of-chronic-pelvic-pain-syndromes-is-interrelated-with-enhanced-clinical-pain
#11
Grinberg Keren, Granot Michal, Lowenstein Lior, Abramov Liora, Weissman-Fogel Irit
Provoked vestibulodynia (PVD) and painful bladder syndrome (PBS), subgroups of chronic pelvic pain syndromes (CPPS), are considered to share common bio-physiological peripheral mechanisms. In addition, indications of a pro-nociceptive pain profile co-existing with psychological vulnerability suggests common dysfunctional pain processing and pain modulation in these two subgroups of CPPS. We therefore aimed at comparing the pain profile and psychological traits of PVD and PBS patients to see whether the pain profile contributes to inter-subject variability of clinical pain symptoms...
February 7, 2017: Pain
https://www.readbyqxmd.com/read/28176893/indacaterol-glycopyrronium-versus-salmeterol-fluticasone-in-asian-patients-with-copd-at-a-high-risk-of-exacerbations-results-from-the-flame-study
#12
Jadwiga A Wedzicha, Nanshan Zhong, Masakazu Ichinose, Michael Humphries, Robert Fogel, Chau Thach, Francesco Patalano, Donald Banerji
BACKGROUND: The FLAME study demonstrated that indacaterol/glycopyrronium (IND/GLY), the fixed-dose combination of a long-acting β2-agonist (LABA, IND) and a long-acting muscarinic antagonist (LAMA, GLY), was superior to salmeterol/fluticasone combination (SFC) in preventing exacerbations in COPD patients with a high risk of exacerbations. In this study, we report a prespecified analysis of the efficacy and safety of IND/GLY versus SFC in Asian patients from the FLAME study. PATIENTS AND METHODS: Patients from Asian centers with moderate-to-very severe COPD and ≥1 exacerbation in the previous year from the 52-week, randomized FLAME study were included...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28175283/european-heart-rhythm-association-ehra-european-association-of-cardiovascular-prevention-and-rehabilitation-eacpr-position-paper-on-how-to-prevent-atrial-fibrillation-endorsed-by-the-heart-rhythm-society-hrs-and-asia-pacific-heart-rhythm-society-aphrs
#13
Bulent Gorenek, Antonio Pelliccia, Emelia J Benjamin, Giuseppe Boriani, Harry J Crijns, Richard I Fogel, Isabelle C Van Gelder, Martin Halle, Gulmira Kudaiberdieva, Deirdre A Lane, Torben Bjerregaard Larsen, Gregory Y H Lip, Maja-Lisa Løchen, Francisco Marín, Josef Niebauer, Prashanthan Sanders, Lale Tokgozoglu, Marc A Vos, David R Van Wagoner, Laurent Fauchier, Irina Savelieva, Andreas Goette, Stefan Agewall, Chern-En Chiang, Márcio Figueiredo, Martin Stiles, Timm Dickfeld, Kristen Patton, Massimo Piepoli, Ugo Corra, Pedro Manuel Marques-Vidal, Pompilio Faggiano, Jean-Paul Schmid, Ana Abreu
No abstract text is available yet for this article.
February 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28144689/the-impact-of-the-right-ventricular-outflow-tract-patch-on-right-ventricular-strain-in-tetralogy-of-fallot-a-comparison-with-valvar-pulmonary-stenosis-utilizing-cardiac-magnetic-resonance
#14
Shafkat Anwar, Matthew A Harris, Kevin K Whitehead, Marc S Keller, Elizabeth Goldmuntz, Mark A Fogel, Laura Mercer-Rosa
A non-contractile transannular patch (TAP) in the right ventricular outflow tract (RVOT) contributes to ventricular dysfunction after tetralogy of Fallot (TOF) repair. We compared regional right ventricular (RV) strain in repaired TOF with valvar pulmonary stenosis (VPS) after balloon valvuloplasty to investigate the effects of TAP. Retrospective review of 26 cardiac magnetic resonance studies of TOF (n = 13) and VPS (n = 13) subjects matched by degree and duration of pulmonary regurgitation (PR). Feature tracking strain analysis was performed...
January 31, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28139655/a-multidisciplinary-approach-to-pancreas-cancer-in-2016-a-review
#15
REVIEW
Evan L Fogel, Safi Shahda, Kumar Sandrasegaran, John DeWitt, Jeffrey J Easler, David M Agarwal, Mackenzie Eagleson, Nicholas J Zyromski, Michael G House, Susannah Ellsworth, Ihab El Hajj, Bert H O'Neil, Attila Nakeeb, Stuart Sherman
In this article, we review our multidisciplinary approach for patients with pancreatic cancer. Specifically, we review the epidemiology, diagnosis and staging, biliary drainage techniques, selection of patients for surgery, chemotherapy, radiation therapy, and discuss other palliative interventions. The areas of active research investigation and where our knowledge is limited are emphasized.Am J Gastroenterol advance online publication, 31 January 2017; doi:10.1038/ajg.2016.610.
January 31, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28129666/non-invasive-proteome-analysis-of-psoriatic-stratum-corneum-reflects-pathophysiological-pathways-and-is-useful-for-drug-profiling
#16
B Méhul, G Laffet, A Séraïdaris, L Russo, P Fogel, I Carlavan, C Pernin, P Andres, C Queille-Roussel, J J Voegel
BACKGROUND: Protein expression is disturbed in psoriatic stratum corneum. Non-invasive methods for the description of pathophysiological changes and drug profiling in psoriasis are desirable. OBJECTIVES: Undertake large scale non-invasive protein expression studies in psoriatic stratum corneum to identify biomarkers of pathophysiological processes and use them for drug profiling. METHODS: Psoriatic stratum corneum was harvested through repetitive tape-stripping...
January 27, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28095816/awareness-and-knowledge-among-internal-medicine-house-staff-for-dose-adjustment-of-commonly-used-medications-in-patients-with-ckd
#17
Sikander Surana, Neeru Kumar, Amita Vasudeva, Gulvahid Shaikh, Kenar D Jhaveri, Hitesh Shah, Deepa Malieckal, Joshua Fogel, Gurwinder Sidhu, Sofia Rubinstein
BACKGROUND: Drug dosing errors result in adverse patient outcomes and are more common in patients with chronic kidney disease (CKD). As internists treat the majority of patients with CKD, we study if Internal Medicine house-staff have awareness and knowledge about the correct dosage of commonly used medications for those with CKD. METHODS: A cross-sectional survey was performed and included 341 participants. The outcomes were the awareness of whether a medication needs dose adjustment in patients with CKD and whether there was knowledge for the level of glomerular filtration rate (GFR) a medication needs to be adjusted...
January 17, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28087134/factors-influencing-and-modifying-the-decision-to-pursue-genetic-testing-for-skin-cancer-risk
#18
Alexander L Fogel, Prajakta D Jaju, Shufeng Li, Bonnie Halpern-Felsher, Jean Y Tang, Kavita Y Sarin
BACKGROUND: Across cancers, the decision to pursue genetic testing is influenced more by subjective than objective factors. However, skin cancer, which is more prevalent, visual, and multifactorial than many other malignancies, may offer different motivations for pursuing such testing. OBJECTIVES: The primary objective was to determine factors influencing the decision to receive genetic testing for skin cancer risk. A secondary objective was to assess the impact of priming with health questions on the decision to receive testing...
January 10, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28071654/responsiveness-of-endoscopic-indices-of-disease-activity-for-crohn-s-disease
#19
Reena Khanna, GuangYong Zou, Larry Stitt, Brian G Feagan, William J Sandborn, Paul Rutgeerts, John W D McDonald, Elena Dubcenco, Ronald Fogel, Remo Panaccione, Vipul Jairath, Sigrid Nelson, Lisa M Shackelton, Bidan Huang, Qian Zhou, Anne M Robinson, Barrett G Levesque, Geert D'Haens
OBJECTIVES: The Crohn's Disease Endoscopic Index of Severity (CDEIS) and the Simple Endoscopic Score for Crohn's Disease (SES-CD) are commonly used to assess Crohn's disease (CD) activity; however neither instrument is fully validated. We evaluated the responsiveness to change of the SES-CD and CDEIS using data from a trial of adalimumab, a drug therapy of known efficacy. METHODS: Paired video recordings (N=112) of colonoscopies (baseline and week 8-12) obtained from patients with CD who participated in a trial of adalimumab therapy were reviewed in random order, in duplicate, by four central readers (56 pairs of videos by 2 groups of readers)...
January 10, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28057210/epigenetic-changes-in-chronic-inflammatory-diseases
#20
O Fogel, C Richard-Miceli, J Tost
The number of people diagnosed with chronic inflammatory diseases has increased noteworthy in the last 40 years. Spondyloarthritis (SpA), inflammatory bowel diseases (IBD), and psoriasis are the most frequent chronic inflammatory diseases, resulting from a combination of genetic predisposition and environmental factors. Epigenetic modifications include DNA methylation, histone modifications, and small and long noncoding RNAs. They are influenced by environmental exposure, life-style, and aging and have recently been shown to be altered in many complex diseases including inflammatory diseases...
2017: Advances in Protein Chemistry and Structural Biology
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