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https://www.readbyqxmd.com/read/28525403/genetic-diseases-associated-with-an-increased-risk-of-skin-cancer-development-in-childhood
#1
Alexander L Fogel, Kavita Y Sarin, Joyce M C Teng
PURPOSE OF REVIEW: Childhood skin cancers are relatively rare and may indicate an underlying genetic disorder. The increasing elucidation of genetic pathways is changing the diagnosis and management of genetic skin cancer susceptibility syndromes. In this review, we provide an overview of genetic conditions that predispose to skin cancer development in childhood and signs that providers should assess when evaluating affected individuals. RECENT FINDINGS: In basal cell nevus syndrome (BCNS), the patched2 (PTCH2) and suppressor of fused (SUFU) genes have been implicated in disease pathogenesis...
May 18, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28522658/effect-of-fontan-geometry-on-exercise-haemodynamics-and-its-potential-implications
#2
Elaine Tang, Zhenglun Alan Wei, Kevin K Whitehead, Reza H Khiabani, Maria Restrepo, Lucia Mirabella, James Bethel, Stephen M Paridon, Bradley S Marino, Mark A Fogel, Ajit P Yoganathan
OBJECTIVE: Exercise intolerance afflicts Fontan patients with total cavopulmonary connections (TCPCs) causing a reduction in quality of life. Optimising TCPC design is hypothesised to have a beneficial effect on exercise capacity. This study investigates relationships between TCPC geometries and exercise haemodynamics and performance. METHODS: This study included 47 patients who completed metabolic exercise stress test with cardiac magnetic resonance (CMR). Phase-contrast CMR images were acquired immediately following supine lower limb exercise...
May 18, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28506538/epitope-specific-immunotherapy-targeting-cd4-positive-t-cells-in-coeliac-disease-two-randomised-double-blind-placebo-controlled-phase-1-studies
#3
Gautam Goel, Tim King, A James Daveson, Jane M Andrews, Janakan Krishnarajah, Richard Krause, Gregor J E Brown, Ronald Fogel, Charles F Barish, Roger Epstein, Timothy P Kinney, Philip B Miner, Jason A Tye-Din, Adam Girardin, Juha Taavela, Alina Popp, John Sidney, Markku Mäki, Kaela E Goldstein, Patrick H Griffin, Suyue Wang, John L Dzuris, Leslie J Williams, Alessandro Sette, Ramnik J Xavier, Ludvig M Sollid, Bana Jabri, Robert P Anderson
BACKGROUND: A gluten-free diet is the only means to manage coeliac disease, a permanent immune intolerance to gluten. We developed a therapeutic vaccine, Nexvax2, designed to treat coeliac disease. Nexvax2 is an adjuvant-free mix of three peptides that include immunodominant epitopes for gluten-specific CD4-positive T cells. The vaccine is intended to engage and render gluten-specific CD4-positive T cells unresponsive to further antigenic stimulation. We assessed the safety and pharmacodynamics of the vaccine in patients with coeliac disease on a gluten-free diet...
May 11, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28496316/the-effect-of-indacaterol-glycopyrronium-versus-tiotropium-or-salmeterol-fluticasone-on-the-prevention-of-clinically-important-deterioration-in-copd
#4
Antonio R Anzueto, Claus F Vogelmeier, Konstantinos Kostikas, Karen Mezzi, Sebastian Fucile, Giovanni Bader, Steven Shen, Donald Banerji, Robert Fogel
BACKGROUND: Endpoints that evaluate deterioration rather than improvement of disease may have clinical utility in COPD. In this analysis, we compared the effects of different maintenance treatments on the prevention of clinically important deterioration (CID) in moderate-to-severe COPD patients. METHODS: Data were analyzed from three 26-week studies comparing indacaterol/glycopyrronium (IND/GLY) with tiotropium (TIO) or salmeterol/fluticasone (SFC). Two definitions of CID were used; each was a composite of three outcome measures typically associated with COPD...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28486656/canopy-gradients-in-leaf-functional-traits-for-species-that-differ-in-growth-strategies-and-shade-tolerance
#5
Adam P Coble, Marilyn L Fogel, Geoffrey G Parker
In temperate deciduous forests, vertical gradients in leaf mass per area (LMA) and area-based leaf nitrogen (Narea) are strongly controlled by gradients in light availability. While there is evidence that hydrostatic constraints on leaf development may diminish LMA and Narea responses to light, inherent differences among tree species may also influence leaf developmental and morphological response to light. We investigated vertical gradients in LMA, Narea and leaf carbon isotope composition (δ13C) for three temperate deciduous species (Carpinus caroliniana Walter, Fagus grandifolia Ehrh...
May 9, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28481902/association-of-hiv-diversity-and-virologic-outcomes-in-early-antiretroviral-treatment-hptn-052
#6
Philip J Palumbo, Ethan A Wilson, Estelle Piwowar-Manning, Marybeth McCauley, Theresa Gamble, Newton Kumwenda, Joseph Makhema, Nagalingeswaran Kumarasamy, Suwat Chariyalertsak, James G Hakim, Mina C Hosseinipour, Marineide G Melo, Sheela V Godbole, Jose H Pilotto, Beatriz Grinsztejn, Ravindre Panchia, Ying Q Chen, Myron S Cohen, Susan H Eshleman, Jessica M Fogel
Higher HIV diversity has been associated with virologic outcomes in children on antiretroviral treatment (ART). We examined the association of HIV diversity with virologic outcomes in adults from the HPTN 052 trial who initiated ART at CD4 cell counts of 350-550 cells/mm3. A high resolution melting (HRM) assay was used to analyze baseline (pre-treatment) HIV diversity in six regions in the HIV genome (two in gag, one in pol, and three in env) from 95 participants who failed ART. We analyzed the association of HIV diversity in each genomic region with baseline (pre-treatment) factors and three clinical outcomes: time to virologic suppression after ART initiation, time to ART failure, and emergence of HIV drug resistance at ART failure...
2017: PloS One
https://www.readbyqxmd.com/read/28471839/impact-of-early-antiretroviral-therapy-on-the-performance-of-hiv-rapid-tests-and-hiv-incidence-assays
#7
Jessica M Fogel, Estelle Piwowar-Manning, Barbara Debevec, Tamara Walsky, Katherine Schlusser, Oliver Laeyendecker, Ethan A Wilson, Marybeth McCauley, Theresa Gamble, Gerald Tegha, MTech Biomed, Dean Soko, Johnstone Kumwenda, Mina C Hosseinipour, Ying Q Chen, Myron S Cohen, Susan H Eshleman
BACKGROUND: Antiretroviral therapy (ART) can down-regulate antibody responses to HIV infection. We evaluated the impact of early vs. delayed ART on the performance of HIV diagnostic and incidence assays. METHODS: Samples were obtained from 207 participants in the HPTN 052 trial who were stably suppressed on ART for ≥4 years (Malawi sites; pre-ART CD4 cell count 350-550 cells/mm [early ART arm, N=180] or <250 cells/mm or an AIDS-defining illness [delayed ART arm, N=27])...
April 26, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28462734/faster-eating-rates-are-associated-with-higher-energy-intakes-during-an-ad-libitum-meal-higher-bmi-and-greater-adiposity-among-4%C3%A2-5-year-old-children-results-from-the-growing-up-in-singapore-towards-healthy-outcomes-gusto-cohort
#8
Anna Fogel, Ai Ting Goh, Lisa R Fries, Suresh A Sadananthan, S Sendhil Velan, Navin Michael, Mya-Thway Tint, Marielle V Fortier, Mei Jun Chan, Jia Ying Toh, Yap-Seng Chong, Kok Hian Tan, Fabian Yap, Lynette P Shek, Michael J Meaney, Birit F P Broekman, Yung Seng Lee, Keith M Godfrey, Mary F F Chong, Ciarán G Forde
Faster eating rates are associated with increased energy intake, but little is known about the relationship between children's eating rate, food intake and adiposity. We examined whether children who eat faster consume more energy and whether this is associated with higher weight status and adiposity. We hypothesised that eating rate mediates the relationship between child weight and ad libitum energy intake. Children (n 386) from the Growing Up in Singapore Towards Healthy Outcomes cohort participated in a video-recorded ad libitum lunch at 4·5 years to measure acute energy intake...
May 2, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28446492/hepatic-fibrosis-is-universal-following-fontan-operation-and-severity-is-associated-with-time-from-surgery-a-liver-biopsy-and-hemodynamic-study
#9
David J Goldberg, Lea F Surrey, Andrew C Glatz, Kathryn Dodds, Michael L O'Byrne, Henry C Lin, Mark Fogel, Jonathan J Rome, Elizabeth B Rand, Pierre Russo, Jack Rychik
BACKGROUND: Congestive hepatopathy is a recognized complication of Fontan physiology. Data regarding the incidence of hepatopathy and risk factors are lacking. METHODS AND RESULTS: Liver biopsies and cardiac catherizations were performed as part of an evaluation offered to all patients ≥10 years after Fontan. Quantitative determination of hepatic fibrosis was performed using Sirius red staining with automated calculation of collagen deposition per slide (%CD)...
April 26, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28442340/empathy-during-consoling-touch-is-modulated-by-mu-rhythm-an-eeg-study
#10
L Peled-Avron, P Goldstein, S Yellinek, I Weissman-Fogel, S G Shamay-Tsoory
The aim of the present study was to examine the mechanisms of empathy for pain that contribute to consoling touch, a distress-alleviating contact behavior carried out by an observer in response to the suffering of a target. We tested romantic couples in a paradigm that involves consoling touch and examined the attenuation of the mu/alpha rhythm (8-13Hz) in the consoling partner. During the task, the toucher either held the consoled partner's right hand (human touch) or held onto the armrest of the chair (non-human touch), while the consoled partner experienced inflicted pain (pain condition) or did not experience any pain (no-pain condition)...
April 22, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28433255/digital-cohorts-within-the-social-mediome-an-approach-to%C3%A2-circumvent-conventional-research-challenges
#11
Anand Kulanthaivel, Rachel Fogel, Josette Jones, Craig Lammert
No abstract text is available yet for this article.
May 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28431979/past-exposure-to-fruit-and-vegetable-variety-moderates-the-link-between-fungiform-papillae-density-and-current-variety-of-fv-consumed-by-children
#12
Anna Fogel, Jackie Blissett
Higher fungiform papillae density (FPD) has been associated with lower taste sensitivity thresholds and greater perceived taste intensity along with consumption of fewer fruit and vegetables (FV). Children exposed to greater variety of FV tend to habitually consume more FV, however, it is unknown whether exposure effects are attenuated by individual differences in FPD or whether these effects vary according to sensory properties of FV. This study examined the links between children's FPD, current variety of FV consumed, and past experiences with variety of fruit and vegetables...
April 19, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28422976/reactivation-or-transformation-motor-memory-consolidation-associated-with-cerebral-activation-time-locked-to-sleep-spindles
#13
Stuart Fogel, Genevieve Albouy, Bradley R King, Ovidiu Lungu, Catherine Vien, Arnaud Bore, Basile Pinsard, Habib Benali, Julie Carrier, Julien Doyon
Motor memory consolidation is thought to depend on sleep-dependent reactivation of brain areas recruited during learning. However, up to this point, there has been no direct evidence to support this assertion in humans, and the physiological processes supporting such reactivation are unknown. Here, simultaneous electroencephalographic and functional magnetic resonance imaging (EEG-fMRI) recordings were conducted during post-learning sleep to directly investigate the spindle-related reactivation of a memory trace formed during motor sequence learning (MSL), and its relationship to overnight enhancement in performance (reflecting consolidation)...
2017: PloS One
https://www.readbyqxmd.com/read/28417993/corrigendum-responsiveness-of-endoscopic-indices-of-disease-activity-for-crohn-s-disease
#14
Reena Khanna, GuangYong Zou, Larry Stitt, Brian G Feagan, William J Sandborn, Paul Rutgeerts, John W D McDonald, Elena Dubcenco, Ronald Fogel, Remo Panaccione, Vipul Jairath, Sigrid Nelson, Lisa M Shackelton, Bidan Huang, Qian Zhou, Anne M Robinson, Barrett G Levesque, Geert D'Haens
No abstract text is available yet for this article.
April 18, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28398316/mhealth-advances-clinical-research-bit-by-bit
#15
Joseph C Kvedar, Alexander L Fogel
No abstract text is available yet for this article.
April 11, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28392467/predicted-coreceptor-usage-at-end-stage-hiv-disease-in-tissues-derived-from-subjects-on-antiretroviral-therapy-with-an-undetectable-plasma-viral-load
#16
S L Lamers, G B Fogel, E S Liu, D J Nolan, M Salemi, A E Barbier, R Rose, E J Singer, M S McGrath
HIV cure research is increasingly focused on anatomical tissues as sites for residual HIV replication during combined antiretroviral therapy (cART). Tissue-based HIV could contribute to low-level immune activation and viral rebound over the course of infection and could also influence the development of diseases, such as atherosclerosis, neurological disorders and cancers. cART-treated subjects have a decreased and irregular presence of HIV among tissues, which has resulted in a paucity of actual evidence concerning how or if HIV persists, replicates and evolves in various anatomical sites during therapy...
April 6, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28389399/integrating-musculoskeletal-education-and-patient-care-at-medical%C3%A2-student-run-free-clinics
#17
Thomas McQuillan, Nate Wilcox-Fogel, Emily Kraus, Amy Ladd, Michael Fredericson
BACKGROUND: Student-run free clinics (SRFCs) have emerged as an important educational component of United States (US) medical schools. Despite the prevalence of musculoskeletal (MSK) problems presenting to SRFCs, students and clinics are often unprepared to diagnose and to treat common MSK complaints. OBJECTIVE: We sought to determine the scope of diagnosis and treatment at a medical student-run free clinic specializing in musculoskeletal care using physical medicine and rehabilitation (PM&R) residents...
April 5, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28389338/bi-phasic-activation-of-the-primary-motor-cortex-by-pain-and-its-relation-to-pain-evoked-potentials-an-exploratory-study
#18
Lee-Bareket Kisler, Irit Weissman-Fogel, Alon Sinai, Elliot Sprecher, Andrei V Chistyakov, Simone Shamay-Tsoory, Nadav Moscovitz, Yelena Granovsky
The primary motor cortex (M1) is a known target for brain stimulation aimed at pain alleviation in chronic pain patients, yet the mechanisms through which analgesia occurs, and the exact pain-motor interrelations are not fully understood. We used noxious contact heat evoked potentials (CHEPs) and cortical source analysis to further explore the relevance of M1 in pain processing. Twenty-four healthy young females received brief noxious heat stimuli to their left non-dominant volar forearm, simultaneously with CHEPs recordings...
April 4, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28385131/virologic-outcomes-in-early-antiretroviral-treatment-hptn-052
#19
Susan H Eshleman, Ethan A Wilson, Xinyi C Zhang, San-San Ou, Estelle Piwowar-Manning, Joseph J Eron, Marybeth McCauley, Theresa Gamble, Joel E Gallant, Mina C Hosseinipour, Nagalingeswaran Kumarasamy, James G Hakim, Ben Kalonga, Jose H Pilotto, Beatriz Grinsztejn, Sheela V Godbole, Nuntisa Chotirosniramit, Breno Riegel Santos, Emily Shava, Lisa A Mills, Ravindre Panchia, Noluthando Mwelase, Kenneth H Mayer, Ying Q Chen, Myron S Cohen, Jessica M Fogel
INTRODUCTION: The HIV Prevention Trials Network (HPTN) 052 trial demonstrated that early antiretroviral therapy (ART) prevented 93% of HIV transmission events in serodiscordant couples. Some linked infections were observed shortly after ART initiation or after virologic failure. OBJECTIVE: To evaluate factors associated with time to viral suppression and virologic failure in participants who initiated ART in HPTN 052. METHODS: 1566 participants who had a viral load (VL) > 400 copies/mL at enrollment were included in the analyses...
April 7, 2017: HIV Clinical Trials
https://www.readbyqxmd.com/read/28380305/integrative-literature-review-of-factors-related-to-breastfeeding-in-african-american-women-evidence-for-a-potential-paradigm-shift
#20
Stephanie DeVane-Johnson, Cheryl Woods-Giscombé, Suzanne Thoyre, Cathie Fogel, Ronald Williams
BACKGROUND: Human milk has widespread health benefits for infants, mothers, and society. However, not all populations of women, particularly African American women, engage in human milk feeding at high rates. Research aim: The purpose of this integrative literature review is twofold: (a) to examine factors that influence low rates of human milk feeding among African American women and (b) to introduce a need for a methodological paradigm shift to develop culturally relevant and effective interventions...
May 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
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