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Meera Mohan, Bradley Fogel, Thomas Eluvathingal, Carolina Schinke, Atul Kothari
A 59-year-old patient with multiple myeloma on maintenance chemotherapy presented with fever, weight loss and night sweats. An F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) computed tomography (CT) showed intra-abdominal lymphadenopathy with a mesenteric mass that led to further work up and diagnosis of histoplamosis. The patient was treated with amphotericin B and subsequently switched to itraconazole. This exemplifies the usefulness of FDG PET CT in diagnosis of infectious complications...
October 1, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Mark A Gromski, Evan L Fogel, Raj Vuppalanchi
No abstract text is available yet for this article.
September 23, 2016: Clinical Gastroenterology and Hepatology
Hila Danino, Ronny Peri- Naor, Chen Fogel, Yael Ben-Harosh, Rotem Kadir, Hagit Salem, Ruth Birk
AIM: Pancreatic lipase (triacylglycerol lipase EC is an essential enzyme in hydrolysis of dietary fat. Dietary fat, especially polyunsaturated fatty acids (PUFA), regulate pancreatic lipase (PNLIP); however, the molecular mechanism underlying this regulation is mostly unknown. As PUFA are known to regulate expression of proliferator-activated receptor gamma (PPARγ), and as we identified in-silico putative PPARγ binding sites within the putative PNLIP promoter sequence, we hypothesized that PUFA regulation of PNLIP might be mediated by PPARγ...
September 20, 2016: Biochimica et Biophysica Acta
James M Whedon, Molly Punzo, Regina Dehen, Martha Brown Menard, David Fogel, Jennifer Olejownik
With the advent of new models for payment and delivery of healthcare services, the use of quality measures for continual improvement of clinical healthcare is now an integral feature of medical practice in the United States. However, quality measurement and quality improvement activities are not common practice among integrative health providers. This article discusses the import and application of quality measurement to the practice of integrative healthcare. It reviews developments in the healthcare quality improvement movement, explores the relevance of quality measures to integrative healthcare, describes examples of the current use of quality measures in integrative health practice, discusses discriminatory policies that may prevent participation in quality improvement by integrative health practitioners, and makes recommendations for practice and policy...
September 23, 2016: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Temel Tirkes, Evan L Fogel, Stuart Sherman, Chen Lin, Jordan Swensson, Fatih Akisik, Kumaresan Sandrasegaran
PURPOSE: To determine if T1-weighted MR signal of the pancreas can be used to detect early CP. METHODS: A retrospective analysis was performed on 51 suspected CP patients, who had both secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) and an intraductal secretin stimulation test (IDST). There were 29 patients in normal and 22 patients in the low bicarbonate group. Bicarbonate level, total pancreatic juice volume, and excretory flow rate were recorded during IDST...
September 23, 2016: Abdominal Radiology
Susanna L Lamers, Rebecca Rose, David J Nolan, Gary B Fogel, Andrew E Barbier, Marco Salemi, Michael S McGrath
Kaposi's sarcoma (KS) in HIV-infected individuals can have a wide range of clinical outcomes, from indolent skin tumors to a life-threatening visceral cancer. KS tumors contain endothelial-related cells and inflammatory cells that may be HIV-infected. In this study we tested if HIV evolutionary patterns distinguish KS tumor relatedness and progression. Multisite autopsies from participants who died from HIV-AIDS with KS prior to the availability of antiretroviral therapy were identified at the AIDS and Cancer Specimen Resource (ACSR)...
2016: Sarcoma
Zhuo Fang, Valya Sergeeva, Laura B Ray, Jeremy Viczko, Adrian M Owen, Stuart M Fogel
Sleep spindles-short, phasic, oscillatory bursts of activity that characterize non-rapid eye movement sleep-are one of the only electrophysiological oscillations identified as a biological marker of human intelligence (e.g., cognitive abilities commonly assessed using intelligence quotient tests). However, spindles are also important for sleep maintenance and are modulated by circadian factors. Thus, the possibility remains that the relationship between spindles and intelligence quotient may be an epiphenomenon of a putative relationship between good quality sleep and cognitive ability or perhaps modulated by circadian factors such as morningness-eveningness tendencies...
September 14, 2016: Journal of Cognitive Neuroscience
Catherine Vien, Arnaud Boré, Ovidiu Lungu, Habib Benali, Julie Carrier, Stuart Fogel, Julien Doyon
Older adults show impaired consolidation in motor sequence learning (MSL) tasks, failing to demonstrate the sleep-dependent performance gains usually seen in young individuals. To date, few studies have investigated the white-matter substrates of MSL in healthy aging, and none have addressed how fiber pathways differences may contribute to the age-related consolidation deficit. Accordingly, we used diffusion-weighted magnetic resonance imaging to explore how white-matter characteristics relate to performance using an explicit MSL task in young and older participants...
August 20, 2016: Neurobiology of Aging
Sofia Rubinstein, Rafael Franjul, Sikander Surana, Joshua Fogel
The 7.5% icodextrin solution is widely used for long-dwell in peritoneal dialysis (PD) regimens as an alternative osmotic agent to glucose. It has been defined as a biocompatible agent because of its iso-osmolarity and is generally safe and well tolerated. Icodextrin and its hydrolyzed metabolites are found in systemic circulation. In serum, icodextrin interferes with amylase determination causing a significantly decreased plasma amylase level making it unreliable for the diagnosis of acute pancreatitis. Lipase measurement provides an alternative and accurate method for diagnosing acute pancreatitis (AP) in patients using icodextrin...
November 2016: Clinical Nephrology
Andy M Tyrrell, Michael A Lones, Stephen L Smith, Gary B Fogel
No abstract text is available yet for this article.
August 2016: Bio Systems
Alexander L Fogel, Joyce Teng, Kavita Y Sarin
Direct-to-consumer teledermatology is radically changing the way some patients obtain dermatologic care. Many direct-to-consumer teledermatology services offer care to patients younger than 18 years, but policies and standards are nonuniform. For pediatric patients, direct-to-consumer teledermatology is a substantial departure from in-person care. More consensus, standards, and guidelines are necessary.
November 2016: Journal of the American Academy of Dermatology
David M Baker, Thaddeus J T Murdoch, Inga Conti-Jerpe, Marilyn Fogel
For centuries, Bermuda has been challenged with wastewater management for the protection of human and environmental health. By quantifying the δ(15)N of the common sea fan Gorgonia ventalina sampled from 30 sites throughout Bermuda we show that sewage-derived nitrogen is detectable on nearshore coral reefs and declines across the lagoon to the outer rim. We also sampled gorgonians from two museum collections representing a 50y time-series (1958-2008). These samples revealed an increase in δ(15)N of >4...
September 3, 2016: Marine Pollution Bulletin
Christian Brendel, Swaroopa Guda, Raffaele Renella, Daniel E Bauer, Matthew C Canver, Young-Jo Kim, Matthew M Heeney, Denise Klatt, Jonathan Fogel, Michael D Milsom, Stuart H Orkin, Richard I Gregory, David A Williams
Reducing expression of the fetal hemoglobin (HbF) repressor BCL11A leads to a simultaneous increase in γ-globin expression and reduction in β-globin expression. Thus, there is interest in targeting BCL11A as a treatment for β-hemoglobinopathies, including sickle cell disease (SCD) and β-thalassemia. Here, we found that using optimized shRNAs embedded within an miRNA (shRNAmiR) architecture to achieve ubiquitous knockdown of BCL11A profoundly impaired long-term engraftment of both human and mouse hematopoietic stem cells (HSCs) despite a reduction in nonspecific cellular toxicities...
October 3, 2016: Journal of Clinical Investigation
Joshua Fogel, Martin Kusz
OBJECTIVES: The only human Lyme disease vaccine of LYMErix was voluntarily removed from the market in the United States in 2002 for a number of reasons. A new human Lyme disease vaccine is currently being developed. We would like any future approved human Lyme disease vaccine to be of interest and marketable to consumers. METHODS: We surveyed 714 participants to determine variables associated with intentions to receive a Lyme disease vaccine. Predictor variables included demographics, protection motivational theory, Lyme disease knowledge, Lyme disease preventive behaviors, beliefs and perceived health...
January 2016: Therapeutic Advances in Vaccines
Susan H Eshleman, Sarah E Hudelson, Andrew D Redd, Ronald Swanstrom, San-San Ou, Xinyi Cindy Zhang, Li-Hua Ping, Estelle Piwowar-Manning, Stephen F Porcella, Matthew F Sievers, Craig A Martens, Daniel Bruno, Elena Dukhovlinova, Marybeth McCauley, Theresa Gamble, Jessica M Fogel, Devin Sabin, Thomas C Quinn, Laurence Gunde, Madalitso Maliwichi, Nehemiah Nhando, Victor Akelo, Sikhulile Moyo, Ravindre Panchia, Nagalingeswaran Kumarasamy, Nuntisa Chotirosniramit, Marineide Gonçalves de Melo, Jose Pilotto, Beatriz Grinsztejn, Kenneth Mayer, Ying Q Chen, James P Hughes, Myron S Cohen
HIV Prevention Trials Network (HPTN) 052 demonstrated that antiretroviral therapy (ART) prevents HIV transmission in serodiscordant couples. HIV from index-partner pairs was analyzed to determine the genetic linkage status of partner infections. Forty-six infections were classified as linked, indicating that the index was the likely source of the partner's infection. Lack of viral suppression and higher index viral load were associated with linked infection. Eight linked infections were diagnosed after the index started ART: four near the time of ART initiation and four after ART failure...
August 16, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Magdalena R Osburn, Katherine S Dawson, Marilyn L Fogel, Alex L Sessions
Hydrogen atoms from water and food are incorporated into biomass during cellular metabolism and biosynthesis, fractionating the isotopes of hydrogen-protium and deuterium-that are recorded in biomolecules. While these fractionations are often relatively constant in plants, large variations in the magnitude of fractionation are observed for many heterotrophic microbes utilizing different central metabolic pathways. The correlation between metabolism and lipid δ(2)H provides a potential basis for reconstructing environmental and ecological parameters, but the calibration dataset has thus far been limited mainly to aerobes...
2016: Frontiers in Microbiology
Harold A Fogel, Elissa S Finkler, Karen Wu, Adam P Schiff, Lukas M Nystrom
BACKGROUND: The intense competition for orthopedic surgery residency positions influences the interview process. The financial impact on residency applicants is less well understood. The purpose of the present study was to define the economic burden of the orthopedic surgery residency interview process while additionally describing how applicants finance the expense. METHODS: We distributed surveys to 48 nonrotating applicants at our institution's residency interview days for the 2015 match year...
2016: Iowa Orthopaedic Journal
Temel Tirkes, Chen Lin, Evan L Fogel, Stuart S Sherman, Qiushi Wang, Kumaresan Sandrasegaran
PURPOSE: To determine if the T1 relaxation time of the pancreas can detect parenchymal changes in mild chronic pancreatitis (CP). MATERIALS AND METHODS: This Institutional Review Board (IRB)-approved, Health Insurance Portability and Accountability Act (HIPAA)-compliant retrospective study analyzed 98 patients with suspected mild CP. Patients were grouped as normal (n = 53) or mild CP (n = 45) based on history, presenting symptomatology, and concordant findings on both the secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) and endoscopic retrograde cholangiopancreatography (ERCP)...
August 13, 2016: Journal of Magnetic Resonance Imaging: JMRI
Alexander L Fogel, Maria Miyar, Joyce M C Teng
Pediatric organ transplant recipients (POTRs) are at risk of developing malignancies due to a combination of immunosuppression, impaired DNA damage repair, and infection with oncogenic viruses. The most commonly developed malignancies in this population are skin cancers, which include nonmelanoma skin cancer, melanoma, Kaposi's sarcoma, and anogenital carcinoma. The literature shows that skin cancers account for 13% to 55% of all cancers that occur after transplantation. Given the increasing number and life expectancy of POTRs, prevention and management of skin cancer in these patients is essential, but there is a substantial knowledge gap in our understanding of the differences in skin cancer development, prevention, and management between POTRs and adult organ transplant recipients (AOTRs), for whom more data are available...
July 28, 2016: Pediatric Dermatology
Susanna L Lamers, Rebecca Rose, Ekaterina Maidji, Melissa Agsalda-Garcia, David J Nolan, Gary B Fogel, Marco Salemi, Debra L Garcia, Paige Bracci, William Yong, Deborah Commins, Jonathan Said, Negar Khanlou, Charles H Hinkin, Miguel Valdes Sueiras, Glenn Mathisen, Suzanne Donovan, Bruce Shiramizu, Cheryl A Stoddart, Michael S McGrath, Elyse J Singer
UNLABELLED: HIV infection treatment strategies have historically defined effectiveness through measuring patient plasma HIV RNA. While combined antiretroviral therapy (cART) can reduce plasma viral load (pVL) to undetectable levels, the degree that HIV is eliminated from other anatomical sites remains unclear. We investigated the HIV DNA levels in 229 varied autopsy tissues from 20 HIV-positive (HIV(+)) cART-treated study participants with low or undetectable plasma VL and cerebrospinal fluid (CSF) VL prior to death who were enrolled in the National Neurological AIDS Bank (NNAB) longitudinal study and autopsy cohort...
October 15, 2016: Journal of Virology
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