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https://www.readbyqxmd.com/read/29140725/reply-to-the-significance-of-eosinophilic-inflammation-in-copd
#1
Nicolas Roche, Kenneth R Chapman, Claus F Vogelmeier, Felix J F Herth, Chau Thach, Robert Fogel, Petter Olsson, Francesco Patalano, Donald Banerji, Jadwiga A Wedzicha
No abstract text is available yet for this article.
November 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29099609/dual-bronchodilation-response-by-exacerbation-history-and-eosinophilia-in-the-flame-study
#2
Alberto Papi, Konstantinos Kostikas, Jadwiga A Wedzicha, Claus F Vogelmeier, Nicolas Roche, Steven Shen, Donald Banerji, Robert Fogel, Francesco Patalano, Kenneth R Chapman
No abstract text is available yet for this article.
November 3, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29081212/low-serum-pancreatic-amylase-and-lipase-values-are-simple-and-useful-predictors-to-diagnose-chronic-pancreatitis
#3
Hyoung-Chul Oh, Chang-Il Kwon, Ihab I. El Hajj, Jeffrey J Easler, James Watkins, Evan L Fogel, Lee McHenry, Stuart Sherman, Michelle K Zimmerman, Glen A Lehman
Background/Aims: This study aimed to evaluate the diagnostic role of low serum amylase and lipase values in the detection of chronic pancreatitis. Methods: Patients underwent endoscopic retrograde cholangiopancreatography and were diagnosed with non-calcific chronic pancreatitis (NCCP; n=99) and calcific chronic pancreatitis (CCP; n=112). Patient serum amylase and lipase values were compared with those of healthy controls (H; n=170). Results: The median serum amylase (normal range, 19 to 86 U/L) and lipase values (7 to 59 U/L) (P₂₅-P₇₅) were 47...
November 15, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29079130/indacaterol-glycopyrronium-a-dual-bronchodilator-for-copd
#4
REVIEW
Donald Banerji, Robert Fogel, Francesco Patalano
Indacaterol/glycopyrronium (IND/GLY) 110/50mg was the first once-daily, long-acting β2-agonist (LABA)/long-acting muscarinic antagonist (LAMA) fixed-dose combination (FDC) approved in Europe for the treatment of chronic obstructive pulmonary disease (COPD). Development of IND/GLY was driven by the need to improve the standard of care for patients with this disease, in terms of symptom control and exacerbation frequency. IGNITE, an adaptive, comprehensive, and innovative Phase 3 development program, demonstrated the efficacy of IND/glycopyrronium in optimising bronchodilation, reducing symptoms, and reducing exacerbations in patients with COPD...
October 24, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/29073302/potential-clinical-benefits-of-a-two-bag-system-for-fluid-management-in-pediatric-intensive-care-unit-patients-with-diabetic-ketoacidosis
#5
Jacqueline P Velasco Md, Joshua Fogel PhD, Robert L Levine Md PhD, Peter Ciminera Md, David Fagan Md, Renee Bargman Md
INTRODUCTION: Diabetic ketoacidosis (DKA) is a life-threatening complication of diabetes mellitus (DM) that requires appropriate treatment with insulin and intravenous fluids. Both one-bag and two-bag systems of fluid management are used to treat pediatric diabetic ketoacidosis. AIM OF THE STUDY: We compare the one-bag and two-bag systems of fluid managementwith regard to incidence of hypoglycemia, serum bicarbonate correction, pH correction and discharge from the pediatric intensive care unit (PICU)...
2017: Pediatric Endocrinology, Diabetes, and Metabolism
https://www.readbyqxmd.com/read/29068314/a-minimally-sufficient-model-for-rib-proximal-distal-patterning-based-on-genetic-analysis-and-agent-based-simulations
#6
Jennifer L Fogel, Daniel L Lakeland, In Kyoung Mah, Francesca V Mariani
For decades, the mechanism of skeletal patterning along a proximal-distal axis has been an area of intense inquiry. Here, we examine the development of the ribs, simple structures that in most terrestrial vertebrates consist of two skeletal elements-a proximal bone and a distal cartilage portion. While the ribs have been shown to arise from the somites, little is known about how the two segments are specified. During our examination of genetically modified mice, we discovered a series of progressively worsening phenotypes that could not be easily explained...
October 25, 2017: ELife
https://www.readbyqxmd.com/read/29067563/using-a-novel-in-vitro-fontan-model-and-condition-specific-real-time-mri-data-to-examine-hemodynamic-effects-of-respiration-and-exercise
#7
Michael Tree, Zhenglun Alan Wei, Phillip M Trusty, Vrishank Raghav, Mark Fogel, Kevin Maher, Ajit Yoganathan
Several studies exist modeling the Fontan connection to understand its hemodynamic ties to patient outcomes (Chopski in: Experimental and Computational Assessment of Mechanical Circulatory Assistance of a Patient-Specific Fontan Vessel Configuration. Dissertation, 2013; Khiabani et al. in J Biomech 45:2376-2381, 2012; Taylor and Figueroa in Annu Rev Biomed 11:109-134, 2009; Vukicevic et al. in ASAIO J 59:253-260, 2013). The most patient-accurate of these studies include flexible, patient-specific total cavopulmonary connections...
October 24, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29063953/magnetic-resonance-myocardial-perfusion-imaging-safety-and-indications-in-pediatrics-and-young-adults
#8
David M Biko, R Thomas Collins, Sara L Partington, Matthew Harris, Kevin K Whitehead, Marc S Keller, Mark A Fogel
The purpose of this study was to assess the safety and indications for cardiac magnetic resonance (CMR) with myocardial perfusion imaging (MPI) in a cohort of children and young adults. A retrospective review of 178 children and young adults who underwent CMR with MPI was performed. Studies were categorized based on study protocols as MPI with resting perfusion only, adenosine stress MPI, exercise-induced stress MPI, and MPI for cardiac mass diagnosis. Relevant clinical history, exam indications, and adverse reactions following gadolinium-based contrast agent and adenosine administration were recorded...
October 24, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29063512/brain-specific-hiv-nef-identified-in-multiple-patients-with-neurological-disease
#9
Susanna L Lamers, Gary B Fogel, Enoch S Liu, Andrew E Barbier, Christopher W Rodriguez, Elyse J Singer, David J Nolan, Rebecca Rose, Michael S McGrath
HIV-1 Nef is a flexible, multifunctional protein with several cellular targets that is required for pathogenicity of the virus. This protein maintains a high degree of genetic variation among intra- and inter-host isolates. HIV Nef is relevant to HIV-associated neurological diseases (HAND) in patients treated with combined antiretroviral therapy because of the protein's role in promoting survival and migration of infected brain macrophages. In this study, we analyzed 2020 HIV Nef sequences derived from 22 different tissues and 31 subjects using a novel computational approach...
October 23, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/29042343/systems-based-training-in-graduate-medical-education-for-service-learning-in-the-state-legislature-in-the-united-states-pilot-study
#10
Shikhar H Shah, Maureen D Clark, Kimberly Hu, Jalene A Shoener, Joshua Fogel, William C Kling, James Ronayne
BACKGROUND: There is a dearth of advocacy training in graduate medical education in the United States. To address this void, the Legislative Education and Advocacy Development (LEAD) course was developed as an interprofessional experience, partnering a cohort of pediatrics residents, fourth-year medical students, and public health students to be trained in evidence-informed health policy making. OBJECTIVE: The objective of our study was to evaluate the usefulness and acceptability of a service-based legislative advocacy course...
October 17, 2017: JMIR Medical Education
https://www.readbyqxmd.com/read/28993871/dual-bronchodilation-with-indacaterol-maleate-glycopyrronium-bromide-compared-with-umeclidinium-bromide-vilanterol-in-patients-with-moderate-to-severe-copd-results-from-two-randomized-controlled-cross-over-studies
#11
Edward Kerwin, Gary T Ferguson, Shahin Sanjar, Thomas Goodin, Anthony Yadao, Robert Fogel, Samopriyo Maitra, Biswajit Sen, Tim Ayers, Donald Banerji
PURPOSE: To compare the efficacy and safety of two long-acting dual bronchodilator combinations: indacaterol/glycopyrrolate (IND/GLY) versus umeclidinium/vilanterol (UMEC/VI). METHODS: Studies A2349 and A2350 were replicate, randomized, double-blind, double-dummy, active-controlled, cross-over studies in patients with moderate-to-severe COPD. Patients were randomized to sequential 12-week treatments of twice-daily IND/GLY 27.5/15.6 μg and once-daily UMEC/VI 62...
December 2017: Lung
https://www.readbyqxmd.com/read/28988207/leg-lean-mass-correlates-with-exercise-systemic-output-in-young-fontan-patients
#12
Catherine M Avitabile, David J Goldberg, Mary B Leonard, Zhenglun Alan Wei, Elaine Tang, Stephen M Paridon, Ajit P Yoganathan, Mark A Fogel, Kevin K Whitehead
OBJECTIVE: We previously described lower leg lean mass Z-scores (LLMZ) in Fontan patients associated with worse peak oxygen consumption on metabolic exercise testing. We hypothesised that LLMZ correlates with indexed systemic flow (Qsi) and cardiac index (CI) on exercise cardiac magnetic resonance (eCMR). METHODS: Thirteen patients had LLM measured by dual-energy X-ray absorptiometry within mean 40 (range 0-258) days of eCMR. LLM was converted to sex and race-specific Z-scores based on healthy reference data...
October 7, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28987247/impact-of-autologous-stem-cell-transplantation-on-blood-pressure-and-renal-function-in-multiple-myeloma-patients
#13
Leah Balsam, Chadi Saad, Camelia Arsene, Joshua Fogel
BACKGROUND: Autologous stem cell transplantation (ASCT) reverses kidney failure in one-third of multiple myeloma (MM) patients, which may lead to blood pressure (BP) improvement. We evaluate the long term impact of ASCT on BP and renal function in MM patients. METHODS: We studied 192 MM patients that underwent ASCT. We compared BP readings and glomerular filtration rate (GFR) at 4 weeks before ASCT, on day of ASCT and post-ASCT at 30, 100 and 180 days. RESULTS: Mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) on day of ASCT and at both 30 and 100 days post-ASCT was significantly lower as compared to pre-ASCT SBP and DBP...
2017: Journal of the National Medical Association
https://www.readbyqxmd.com/read/28967494/maxillary-first-molars-with-2-distobuccal-canals-a-case-series
#14
Howard M Fogel, Rodrigo Sanches Cunha
An appreciation of the anatomic complexity of the root canal system is essential at every step of endodontic treatment. Endodontic treatment of teeth with unusual root canal anatomy presents a unique challenge. Eight patients underwent nonsurgical root canal treatment of 3-rooted maxillary first molars in a specialty endodontic private practice. Four cases of Weine type II and 4 cases of Weine type III canal configurations in the distobuccal root of maxillary first molars were presented.This article highlighted an uncommon anatomic variation of 2 canals in the distobuccal root of the maxillary first molar...
November 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28943992/go-along-interviewing-with-lgbtq-youth-in-canada-and-the-united-states
#15
Carolyn M Porta, Heather L Corliss, Jennifer M Wolowic, Abigail Z Johnson, Katie Fritz Fogel, Amy L Gower, Elizabeth M Saewyc, Marla E Eisenberg
Go-along interviews, which are interviews conducted whilst being in and moving within participant selected spaces, were conducted with 66 LGBTQ adolescents (14-19 years old) in their self-identified communities to explore perceived community attributes, including safe spaces, resources, and supports; this paper highlights methodological lessons learned. Successful recruitment in two countries and varied community settings required partnership with local LGBTQ supporting agencies, including school-based Gay Straight Alliances...
2017: Journal of LGBT Youth
https://www.readbyqxmd.com/read/28916184/role-of-the-il-12-il-35-balance-in-sj%C3%A3-gren-s-syndrome
#16
Olivier Fogel, Elodie Rivière, Raphaèle Seror, Gaetane Nocturne, Saida Boudaoud, Bineta Ly, Jacques-Eric Gottenberg, Véronique Le Guern, Jean-Jacques Dubost, Joanne Nititham, Kimberly E Taylor, Philippe Chanson, Philippe Dieudé, Lindsey A Criswell, Bernd Jagla, Alice Thai, Michael Mingueneau, Xavier Mariette, Corinne Miceli-Richard
BACKGROUND: An interferon (IFN) signature is involved in the pathogenesis of primary Sjögren's syndrome (pSS), but whether the signature is type 1 or 2 remains controversial. Mouse models and genetic studies suggested the involvement of T helper 1 and type 2 IFN pathways. Likewise, polymorphisms of interleukin 12A gene (IL-12A), which encodes for IL-12p35, have been associated with pSS. IL-12p35 subunit is shared by 2 heterodimers, IL-12 and IL-35. OBJECTIVE: To confirm the genetic association of IL-12A polymorphism and pSS and elucidate the involvement of the IL-12/IL-35 balance in pSS by functional studies...
September 12, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28915542/comparative-susceptibility-of-two-neotropical-predators-eriopis-connexa-and-chrysoperla-externa-to-acetamiprid-and-pyriproxyfen-short-and-long-term-effects-after-egg-exposure
#17
Federico Rimoldi, Marilina N Fogel, Alicia E Ronco, Marcela I Schneider
Compatibility assessments between selective insecticides and the natural enemies of pests are essential for integrated-pest-management programs. Chrysoperla externa and Eriopis connexa are two principal Neotropical predators of agricultural pests whose conservation in agroecosystems requires a toxicity evaluation of pesticides to minimize the impact on those beneficial insects on the environment. The objective of this work was to evaluate the toxicity of the insecticides pyriproxyfen and acetamiprid on C. externa and E...
December 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28893064/aqueous-raft-synthesis-of-glycopolymers-for-determination-of-saccharide-structure-and-concentration-effects-on-amyloid-%C3%AE-aggregation
#18
Pradipta K Das, Dexter N Dean, April L Fogel, Fei Liu, Brooks A Abel, Charles L McCormick, Eugenia Kharlampieva, Vijayaraghavan Rangachari, Sarah E Morgan
GM1 ganglioside is known to promote amyloid-β (Aβ) peptide aggregation in Alzheimer's disease. The roles of the individual saccharides and their distribution in this process are not understood. Acrylamide-based glycomonomers with either β-d-glucose or β-d-galactose pendant groups were synthesized to mimic the stereochemistry of saccharides present in GM1 and characterized via (1)H NMR and electrospray ionization mass spectrometry. Glycopolymers of different molecular weights were synthesized by aqueous reversible addition-fragmentation chain transfer (aRAFT) polymerization and characterized by NMR and GPC...
October 9, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28892464/network-wide-reorganization-of-procedural-memory-during-nrem-sleep-revealed-by-fmri
#19
Shahabeddin Vahdat, Stuart Fogel, Habib Benali, Julien Doyon
Sleep is necessary for the optimal consolidation of newly acquired procedural memories. However, the mechanisms by which motor memory traces develop during sleep remain controversial in humans, as this process has been mainly investigated indirectly by comparing pre- and post-sleep conditions. Here, we used functional magnetic resonance imaging and electroencephalography during sleep following motor sequence learning to investigate how newly-formed memory traces evolve dynamically over time. We provide direct evidence for transient reactivation followed by downscaling of functional connectivity in a cortically-dominant pattern formed during learning, as well as gradual reorganization of this representation toward a subcortically-dominant consolidated trace during non-rapid eye movement (NREM) sleep...
September 11, 2017: ELife
https://www.readbyqxmd.com/read/28839217/re-stepping-into-the-same-river-competition-problem-rather-than-a-reconsolidation-failure-in-an-established-motor-skill
#20
Ella Gabitov, Arnaud Boutin, Basile Pinsard, Nitzan Censor, Stuart M Fogel, Geneviève Albouy, Bradley R King, Habib Benali, Julie Carrier, Leonardo G Cohen, Avi Karni, Julien Doyon
Animal models suggest that consolidated memories return to their labile state when reactivated and need to be restabilized through reconsolidation processes to persist. Consistent with this notion, post-reactivation pharmacological protein synthesis blockage results in mnemonic failure in hippocampus-dependent memories. It has been proposed that, in humans, post-reactivation experience with a competitive task can also interfere with memory restabilization. However, several studies failed to induce performance deficit implementing this approach...
August 24, 2017: Scientific Reports
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