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https://www.readbyqxmd.com/read/29785100/gender-specific-estimates-of-copd-prevalence-a-systematic-review-and-meta-analysis
#1
Georgios Ntritsos, Jacob Franek, Lazaros Belbasis, Maria A Christou, Georgios Markozannes, Pablo Altman, Robert Fogel, Tobias Sayre, Evangelia E Ntzani, Evangelos Evangelou
Rationale: COPD has been perceived as being a disease of older men. However, >7 million women are estimated to live with COPD in the USA alone. Despite a growing body of literature suggesting an increasing burden of COPD in women, the evidence is limited. Objectives: To assess and synthesize the available evidence among population-based epidemiologic studies and calculate the global prevalence of COPD in men and women. Materials and methods: A systematic review and meta-analysis reporting gender-specific prevalence of COPD was undertaken...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29779986/photodynamic-therapy-corrects-abnormal-cancer-associated-gene-expression-observed-in-actinic-keratosis-lesions-and-induces-a-remodeling-effect-in-photodamaged-skin
#2
Florence Joly, Sophie Deret, Bastien Gamboa, Corinne Menigot, Paul Fogel, Carine Mounier, Pascale Reiniche, Farzaneh Sidou, Jérome Aubert, John Lear, Anthony A Fryer, Francesca Zolezzi, Johannes J Voegel
BACKGROUND: Actinic keratoses (AK) are proliferations of neoplastic keratinocytes in the epidermis resulting from cumulative exposure to ultraviolet radiation (UVR), which are liable to transform into squamous cell carcinoma (SCC). Organ Transplant Recipients (OTR) have an increased risk of developing SCC as a consequence of long-term immunosuppressive therapy. The aim of this study was to determine the molecular signature of AKs from OTR prior to treatment with methyl aminolevulinate-photodynamic therapy (MAL-PDT), and to assess what impact the treatment has on promoting remodeling of the photo-damaged skin...
May 17, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29779416/long-term-triple-therapy-de-escalation-to-indacaterol-glycopyrronium-in-copd-patients-sunset-a-randomized-double-blind-triple-dummy-clinical-trial
#3
Kenneth R Chapman, John R Hurst, Stefan-Marian Frent, Michael Larbig, Robert Fogel, Tadhg Guerin, Donald Banerji, Francesco Patalano, Pankaj Goyal, Pascal Pfister, Konstantinos Kostikas, Jadwiga A Wedzicha
RATIONALE: There are no studies on ICS withdrawal in patients on long-term triple therapy in the absence of frequent exacerbations. OBJECTIVE: To evaluate the efficacy and safety of the direct de-escalation from long-term triple therapy to indacaterol/glycopyrronium in non-frequently exacerbating COPD patients. METHODS: This 26-week, randomized, double-blind, triple-dummy study assessed the direct change from long-term triple therapy to indacaterol/glycopyrronium (110/50μg once daily) or continuation of triple therapy (tiotropium 18μg once daily plus combination of salmeterol/fluticasone propionate [50/500μg] twice daily) in non-frequently exacerbating patients with moderate-to-severe COPD...
May 20, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29776718/high-urinary-ferritin-reflects-myoglobin-iron-evacuation-in-dmd-patients
#4
Jérémy Rouillon, Thibaud Lefebvre, Jérôme Denard, Vincent Puy, Raed Daher, Jérôme Ausseil, Aleksandar Zocevic, Paul Fogel, Katell Peoc'h, Brenda Wong, Laurent Servais, Thomas Voit, Herve Puy, Zoubida Karim, Fedor Svinartchouk
Duchenne muscular dystrophy (DMD) is an X-linked disease caused by mutations in the dystrophin gene leading to the absence of the normal dystrophin protein. The efforts of many laboratories brought new treatments of DMD to the reality, but ongoing and forthcoming clinical trials suffer from absence of valuable biomarkers permitting to follow the outcome of the treatment day by day and to adjust the treatment if needed. In the present study the levels of 128 urinary proteins including growth factors, cytokines and chemokines were compared in urine of DMD patients and age related control subjects by antibody array approach...
March 20, 2018: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29776653/accuracy-of-phase-contrast-velocity-mapping-proximal-and-distal-to-stent-artifact-during-cardiac-magnetic-resonance-imaging
#5
Catherine M Avitabile, Matthew A Harris, Ravi S Doddasomayajula, Steven G Chopski, Matthew J Gillespie, Yoav Dori, Andrew C Glatz, Mark A Fogel, Kevin K Whitehead
Little data are available on the accuracy of phase-contrast magnetic resonance imaging (PC-MRI) velocity mapping in the vicinity of intravascular metal stents other than nitinol stents. Therefore, we sought to determine this accuracy using in vitro experiments. An in vitro flow phantom was used with 3 stent types: (1) 316L stainless steel, (2) nitinol self-expanding, and (3) platinum-iridium. Steady and pulsatile flow was delivered with a magnetic resonance imaging-compatible pump (CardioFlow 5000, Shelley Medical, London, Ontario, Canada)...
April 20, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29753200/substance-exposed-newborn-infants-and-public-health-law-differences-in-addressing-the-legal-mandate-to-report
#6
Jordan J Hoerr, Anthony M Heard, Meredith M Baker, Joshua Fogel, Anne Elizabeth Glassgow, William C Kling, Maureen D Clark, James P Ronayne
Prenatal exposure to illicit substances is a finding that typically requires reporting to a child protective services agency. We examine whether there is differential reporting to two public agencies, and whether it varies by race/ethnicity and region. We also study predictors of indicating a maltreatment report as credible. Data on positive neonatal toxicology reports were obtained from the Illinois Department of Public Health (IDPH) and the Illinois Department of Children and Family Services (DCFS). Variation in reporting rates by race/ethnicity and region were compared with Pearson chi-square analysis...
May 9, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29729878/2018-acc-hrs-nasci-scai-scct-expert-consensus-document-on-optimal-use-of-ionizing-radiation-in-cardiovascular-imaging-best-practices-for-safety-and-effectiveness-part-2-radiological-equipment-operation-dose-sparing-methodologies-patient-and-medical-personnel
#7
John W Hirshfeld, Victor A Ferrari, Frank M Bengel, Lisa Bergersen, Charles E Chambers, Andrew J Einstein, Mark J Eisenberg, Mark A Fogel, Thomas C Gerber, David E Haines, Warren K Laskey, Marian C Limacher, Kenneth J Nichols, Daniel A Pryma, Gilbert L Raff, Geoffrey D Rubin, Donnette Smith, Arthur E Stillman, Suma A Thomas, Thomas T Tsai, Louis K Wagner, L Samuel Wann
No abstract text is available yet for this article.
April 30, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29729877/2018-acc-hrs-nasci-scai-scct-expert-consensus-document-on-optimal-use-of-ionizing-radiation-in-cardiovascular-imaging-best-practices-for-safety-and-effectiveness-a-report-of-the-american-college-of-cardiology-task-force-on-expert-consensus-decision-pathways
#8
John W Hirshfeld, Victor A Ferrari, Frank M Bengel, Lisa Bergersen, Charles E Chambers, Andrew J Einstein, Mark J Eisenberg, Mark A Fogel, Thomas C Gerber, David E Haines, Warren K Laskey, Marian C Limacher, Kenneth J Nichols, Daniel A Pryma, Gilbert L Raff, Geoffrey D Rubin, Donnette Smith, Arthur E Stillman, Suma A Thomas, Thomas T Tsai, Louis K Wagner, L Samuel Wann
No abstract text is available yet for this article.
April 30, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29729876/2018-acc-hrs-nasci-scai-scct-expert-consensus-document-on-optimal-use-of-ionizing-radiation-in-cardiovascular-imaging-best-practices-for-safety-and-effectiveness-part-1-radiation-physics-and-radiation-biology
#9
John W Hirshfeld, Victor A Ferrari, Frank M Bengel, Lisa Bergersen, Charles E Chambers, Andrew J Einstein, Mark J Eisenberg, Mark A Fogel, Thomas C Gerber, David E Haines, Warren K Laskey, Marian C Limacher, Kenneth J Nichols, Daniel A Pryma, Gilbert L Raff, Geoffrey D Rubin, Donnette Smith, Arthur E Stillman, Suma A Thomas, Thomas T Tsai, Louis K Wagner, L Samuel Wann
No abstract text is available yet for this article.
April 30, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29727315/autopsy-features-of-fatal-donkey-attack
#10
Lajos Fogel, Gyula Varga, Marta Hubay, Endre Felszeghy, Peter Varga, Roger W Byard
Lethal donkey attacks have very rarely been described. The case of a 65-year-old man who was found deceased on a country road with 2 domestic donkeys nearby is, therefore, reported. Examination of the body revealed contusions and lacerations of the face and scalp, a comminuted fracture of the left maxilla, comminuted fracturing of the right radius and ulna and of the left anterior superior iliac spine, a flail chest, and pulmonary contusions. In addition, there were bite marks on the left thigh, right buttock, right axilla/upper arm, and left cheek which corresponded to the dental arcades of the donkeys...
May 2, 2018: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/29724225/towards-development-of-aptamers-that-specifically-bind-to-lactate-dehydrogenase-of-plasmodium-falciparum-through-epitopic-targeting
#11
Kelly-Anne Frith, Ronen Fogel, J P Dean Goldring, Robert G E Krause, Makobetsa Khati, Heinrich Hoppe, Mary E Cromhout, Meesbah Jiwaji, Janice L Limson
BACKGROUND: Early detection is crucial for the effective treatment of malaria, particularly in those cases infected with Plasmodium falciparum. There is a need for diagnostic devices with the capacity to distinguish P. falciparum from other strains of malaria. Here, aptamers generated against targeted species-specific epitopes of P. falciparum lactate dehydrogenase (rPfLDH) are described. RESULTS: Two classes of aptamers bearing high binding affinity and specificity for recombinant P...
May 3, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29723082/microbial-analysis-of-donor-corneoscleral-rims-and-storage-media
#12
Edmund Tsui, Preston M Luong, Jessa Fogel, Erin S Fogel, Michael E Zegans
PURPOSE: We aim to investigate bacterial and fungal cultures of hypothermic donor corneal storage media (Optisol-GS) and donor rims. METHODS: All corneal transplants performed from January 1, 2015 to June 30, 2016 by a single surgeon at a single facility were retrospectively reviewed. Aerobic, anaerobic, and fungal cultures were routinely obtained from all donor rims and cornea storage media. Culture results and clinical courses were recorded. RESULTS: Eighty-four corneal transplants were performed...
May 3, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29713156/indacaterol-glycopyrronium-reduces-the-risk-of-clinically-important-deterioration-after-direct-switch-from-baseline-therapies-in-patients-with-moderate-copd-a-post-hoc-analysis-of-the-crystal-study
#13
Timm Greulich, Konstantinos Kostikas, Mina Gaga, Maryam Aalamian-Mattheis, Nadine S Lossi, Francesco Patalano, Xavier Nunez, Veronica A Pagano, Robert Fogel, Claus F Vogelmeier, Andreas Clemens
Purpose: COPD is a progressive disease characterized by exacerbations and a decline in health status and lung function. Clinically important deterioration (CID) is a composite endpoint used to evaluate treatment efficacy. This analysis evaluated the impact of a direct switch to once-daily indacaterol/glycopyrronium 110/50 µg (IND/GLY) from previous monotherapy with a long-acting β2 -agonist (LABA) or long-acting muscarinic antagonist (LAMA) or with an LABA and an inhaled corticosteroid (LABA + ICS) on reducing CID...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29698982/a-fast-track-to-hypoalgesia-the-anaerobic-exercise-effect-on-pain-sensitivity
#14
Gil Samuelly-Leichtag, Einat Kodesh, Yoav Meckel, Irit Weissman-Fogel
Maximal anaerobic exercise, is a short high intensity effort, involves activation of the hypothalamus-pituitary-adrenal axis, and may suggest hypoalgesic effects. In addition, this exercise-induced muscle pain may contribute to hypoalgesia via the pain inhibits pain phenomenon, which is related to the diffuse noxious inhibitory control (DNIC) mechanism. We aimed to investigate whether: 1) a single bout of 30 s maximal anaerobic exercise has an analgesic effect on experimental pain sensitivity; 2) DNIC is the underlying mechanism of anaerobic exercise-induced hypoalgesia (EIH)...
April 26, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29692607/exacerbation-heterogeneity-in-copd-subgroup-analyses-from-the-flame-study
#15
Claus F Vogelmeier, Kenneth R Chapman, Marc Miravitlles, Nicolas Roche, Jørgen Vestbo, Chau Thach, Donald Banerji, Robert Fogel, Francesco Patalano, Petter Olsson, Konstantinos Kostikas, Jadwiga A Wedzicha
Background: The FLAME study compared once-daily indacaterol/glycopyrronium (IND/GLY) 110/50 μg with twice-daily salmeterol/fluticasone (SFC) 50/500 μg in symptomatic patients with moderate to very severe COPD and a history of exacerbations in the previous year. Methods: This prespecified and post hoc subgroup analysis evaluated treatment efficacy on 1) moderate/severe exacerbations according to prior exacerbation history and treatment, and 2) types of exacerbations according to health care resource utilization (HCRU) during 1-year follow-up...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29687402/verbal-and-spatial-working-memory-among-drug-using-hiv-infected-men-and-women
#16
Eileen Martin, M K Keutmann, J S Fogel, P M Maki, R Gonzalez, J Vassileva, L H Rubin, D Hardy
Working memory (WM) is a critical component of many neurocognitive functions. The literature has demonstrated consistently that WM impairment is more frequent and severe among substance-dependent individuals (SDIs) infected with HIV compared with uninfected SDIs; however, the SDIs who participated in these previous studies were primarily male. There are few published data on WM performance among HIV+ women with or without substance use disorders, and essentially no direct comparisons of WM performance between HIV+ men and women, regardless of substance use...
April 23, 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29671795/4-hydroxypiperidines-and-their-flexible-3-amino-propyloxy-analogues-as-non-imidazole-histamine-h%C3%A2-receptor-antagonist-further-structure%C3%A2-activity-relationship-exploration-and-in-vitro-and-in-vivo-pharmacological-evaluation
#17
Beata Olszewska, Anna Stasiak, Daniel McNaught Flores, Wiesława Agnieszka Fogel, Rob Leurs, Krzysztof Walczyński
Presynaptic histamine H₃ receptors (H₃R) act as auto- or heteroreceptors controlling, respectively, the release of histamine and of other neurotransmitters in the central nervous system (CNS). The extracellular levels of several neurotransmitters are enhanced by H₃R antagonists, and there is a great interest for potent, brain-penetrating H₃ receptor antagonists/inverse agonists to compensate for the neurotransmitter deficits present in various neurological disorders. We have shown that 1-[(benzylfuran-2-yl)methyl]piperidinyl-4-oxyl- and benzyl- derivatives of N -propylpentan-1-amines exhibit high in vitro potencies toward the guinea pig H₃ receptor (jejunum), with pA₂ = 8...
April 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29663317/atrophic-scar-formation-in-acne-patients-involves-long-acting-immune-responses-with-plasma-cells-and-alteration-of-sebaceous-glands
#18
I Carlavan, B Bertino, M Rivier, P Martel, V Bourdes, M Motte, S Déret, P Reiniche, C Menigot, A Khammari, B Dreno, P Fogel, J J Voegel
BACKGROUND: Possible outcomes of acne lesions are atrophic scars which may cause serious psychological distress. Current treatments of post-acne scarring often require invasive procedures. Pathophysiological studies on acne scarring investigated only the first week of papule life. OBJECTIVES: Study the pathophysiology of atrophic scar formation to identify molecular and cellular pathways that can lead to new therapies for the prevention of acne scarring. METHODS: Large-scale gene expression profiling and immunohistochemistry analysis were performed on uninvolved skin and papules in both, scar-prone (SP) and non-scar-prone (NSP) acne patients, at different time points...
April 16, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29658810/early-changes-in-ediary-copd-symptoms-predict-clinically-relevant-treatment-response-at-12-weeks-analysis-from-the-crystal-study
#19
Konstantinos Kostikas, Maryam Aalamian-Mattheis, Veronica Anna Pagano, Xavier Nunez, Robert Fogel, Francesco Patalano, Andreas Clemens
Early detection of treatment response is important in the long-term treatment and management of patients with chronic obstructive pulmonary disease (COPD). This analysis evaluated whether early improvement in symptoms, recorded in the first 7 or 14 days via an electronic diary (eDiary) compared with baseline, can predict clinically meaningful treatment responders at 12 weeks. CRYSTAL was a 12-week, randomized, open-label study that demonstrated the increased effectiveness of indacaterol/glycopyrronium (IND/GLY) or glycopyrronium (GLY), after a direct switch from on-going baseline therapies, in patients with symptomatic COPD and moderate airflow obstruction...
April 16, 2018: COPD
https://www.readbyqxmd.com/read/29644874/impact-of-a-no-mobile-device-policy-on-developmental-surveillance-in-a-pediatric-clinic
#20
Paul A Regan, Benjamin S Fogel, Steven D Hicks
Children commonly use mobile devices at pediatric office visits. This practice may affect patient-provider interaction and undermine accuracy of developmental surveillance. A randomized, provider-blinded, controlled trial examined whether a policy prohibiting mobile device use in a pediatric clinic improved accuracy of pediatricians' developmental surveillance. Children, aged 18 to 36 months, were randomized to device-prohibited (intervention; n = 58) or device-allowed (control; n = 54) groups. After a 30-minute well-visit, development was evaluated as "normal," "borderline," or "delayed" in 5 categories using the Ages and Stages Questionnaire (ASQ-3)...
April 1, 2018: Clinical Pediatrics
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