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https://www.readbyqxmd.com/read/29346085/performance-of-the-bioplex-2200-hiv-ag-ab-assay-for-identifying-acute-hiv-infection
#1
Susan H Eshleman, Estelle Piwowar-Manning, Mariya V Sivay, Barbara Debevec, Stephanie Veater, Laura McKinstry, Linda-Gail Bekker, Sharon Mannheimer, Robert M Grant, Margaret A Chesney, Thomas J Coates, Beryl A Koblin, Jessica M Fogel
BACKGROUND: Assays that detect HIV antigen (Ag) and antibody (Ab) can be used to screen for HIV infection. OBJECTIVES: To compare the performance of the BioPlex 2200 HIV Ag-Ab assay and two other Ag/Ab combination assays for detection of acute HIV infection. STUDY DESIGN: Samples were obtained from 24 individuals (18 from the US, 6 from South Africa); these individuals were classified as having acute infection based on the following criteria: positive qualitative RNA assay; two negative rapid tests; negative discriminatory test...
January 11, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29340873/fontan-surgical-planning-previous-accomplishments-current-challenges-and-future-directions
#2
Phillip M Trusty, Timothy C Slesnick, Zhenglun Alan Wei, Jarek Rossignac, Kirk R Kanter, Mark A Fogel, Ajit P Yoganathan
The ultimate goal of Fontan surgical planning is to provide additional insights into the clinical decision-making process. In its current state, surgical planning offers an accurate hemodynamic assessment of the pre-operative condition, provides anatomical constraints for potential surgical options, and produces decent post-operative predictions if boundary conditions are similar enough between the pre-operative and post-operative states. Moving forward, validation with post-operative data is a necessary step in order to assess the accuracy of surgical planning and determine which methodological improvements are needed...
January 16, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29339558/does-sleep-facilitate-the-consolidation-of-allocentric-or-egocentric-representations-of-implicitly-learned-visual-motor-sequence-learning
#3
Jeremy Viczko, Valya Sergeeva, Laura B Ray, Adrian M Owen, Stuart M Fogel
Sleep facilitates the consolidation (i.e., enhancement) of simple, explicit (i.e., conscious) motor sequence learning (MSL). MSL can be dissociated into egocentric (i.e., motor) or allocentric (i.e., spatial) frames of reference. The consolidation of the allocentric memory representation is sleep-dependent, whereas the egocentric consolidation process is independent of sleep or wake for explicit MSL. However, it remains unclear the extent to which sleep contributes to the consolidation of implicit (i.e., unconscious) MSL, nor is it known what aspects of the memory representation (egocentric, allocentric) are consolidated by sleep...
February 2018: Learning & Memory
https://www.readbyqxmd.com/read/29335015/cryptic-diversity-in-an-atlantic-forest-malaria-vector-from-the-mountains-of-south-east-brazil
#4
Guilherme de Rezende Dias, Thais Tenorio Soares Fujii, Bernardo Fernandes Fogel, Ricardo Lourenço-de-Oliveira, Teresa Fernandes Silva-do-Nascimento, André Nóbrega Pitaluga, Carlos José Carvalho-Pinto, Antonio Bernardo Carvalho, Alexandre Afrânio Peixoto, Luísa Damazio Pitaluga Rona
BACKGROUND: Anopheles (Kerteszia) cruzii is the primary vector of human and simian malarias in Brazilian regions covered by the Atlantic Rainforest. Previous studies found that An. cruzii presents high levels of behavioural, chromosomal and molecular polymorphisms, which led to the hypothesis that it may be a complex of cryptic species. Here, An. cruzii specimens were collected in five sites in South-East Brazil located at different altitudes on the inner and coastal slopes of two mountain ranges covered by Atlantic Rainforest, known as Serra do Mar and Serra da Mantiqueria...
January 15, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29331629/growth-and-maturity-a-quantitative-systematic-review-and-network-analysis-in-anthropometric-history
#5
Gregori Galofré-Vilà
This paper reviews the current wealth of anthropometric history since the early efforts of Robert Fogel in the 1970s. The survey is based on a quantitative systematic review of the literature and counts a total of 447 peer-reviewed articles being published in the main leading journals in economic history, economics and biology. Data are analysed using network analysis by journal and author and the main contributions of anthropometric history are highlighted, pointing to future areas of inquiry. The contributions of books and book chapters are also quantified and analysed...
December 16, 2017: Economics and Human Biology
https://www.readbyqxmd.com/read/29325611/autosomal-recessive-cerebellar-ataxias
#6
Brent L Fogel
The autosomal-recessive cerebellar ataxias comprise more than half of the known genetic forms of ataxia and represent an extensive group of clinically heterogeneous disorders that can occur at any age but whose onset is typically prior to adulthood. In addition to ataxia, patients often present with polyneuropathy and clinical symptoms outside the nervous system. The most common of these diseases is Friedreich ataxia, caused by mutation of the frataxin gene, but recent advances in genetic analysis have greatly broadened the ever-expanding number of causative genes to over 50...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29325607/genetic-and-genomic-testing-for-neurologic-disease-in-clinical-practice
#7
Brent L Fogel
The influence of genetics on neurologic disease is broad and it is becoming more common that clinicians are presented with a patient whose disease is likely of genetic origin. In the search for mutations causing Mendelian disorders, advances in genetic testing methodology have propelled modern neurologic practice beyond single-gene testing into the realm of genomic medicine, where routine evaluations encompass hundreds or thousands of genes, or even the entire exome, representing all protein-coding genes in the genome...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29312568/transcriptional-response-to-hypoxic-stress-in-melanoma-and-prognostic-potential-of-gbe1-and-bnip3
#8
Stéphanie Buart, Stéphane Terry, Muhammad Z Noman, Emilie Lanoy, Céline Boutros, Paul Fogel, Philippe Dessen, Guillaume Meurice, Yann Gaston-Mathé, Philippe Vielh, Séverine Roy, Emilie Routier, Virginie Marty, Sophie Ferlicot, Luc Legrès, Morad El Bouchtaoui, Nyam Kamsu-Kom, Jane Muret, Eric Deutsch, Alexander Eggermont, Jean-Charles Soria, Caroline Robert, Salem Chouaib
Gradients of hypoxia occur in most solid tumors and cells found in hypoxic regions are associated with the most aggressive and therapy-resistant fractions of the tumor. Despite the ubiquity and importance of hypoxia responses, little is known about the variation in the global transcriptional response to hypoxia in melanoma. Using microarray technology, whole genome gene expression profiling was first performed on established melanoma cell lines. From gene set enrichment analyses, we derived a robust 35 probes signature (hypomel for HYPOxia MELanoma) associated with hypoxia-response pathways, including 26 genes up regulated, and 9 genes down regulated...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29288855/biomechanical-analysis-of-porous-additive-manufactured-cages-for-lateral-lumbar-interbody-fusion-a-finite-element-analysis
#9
Zhenjun Zhang, Hui Li, Guy R Fogel, Zhenhua Liao, Yang Li, Weiqiang Liu
BACKGROUND: A porous additive manufactured (AM) cage may provide stability similar to that of traditional solid cages, and may be beneficial to bone ingrowth. The biomechanical influence of various porous cages on stability, subsidence, stresses in cage, and facet contact force has not been fully described. The purpose of this study was to verify biomechanical effects of porous AM cages. METHODS: The surgical FE models with various cages were constructed. The partially porous titanium (PPT) cages and fully porous titanium (FPT) cages were applied...
December 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29285641/core-body-temperature-but-not-intraabdominal-pressure-predicts-postoperative-complications-following-closed-system-hyperthermic-intraperitoneal-chemotherapy-hipec-administration
#10
M Goldenshluger, D Zippel, A Ben-Yaacov, J Dux, T Yalon, A Zendel, S Rayman, E Mor, H Berkenstadt, H Fogel-Grinvald, M Ventorrero, A Nissan
BACKGROUND: Hyperthermic intraperitoneal chemotherapy (HIPEC) following cytoreductive surgery (CRS), performed using closed-abdomen technique (CAT), may affect intraabdominal pressure (IAP). High IAP may increase postoperative complications due to decreased venous return and hypoperfusion to vital organs. Elevated core body temperature (CBT) may cause multiorgan dysfunction. Low IAP or CBT could result in suboptimal HIPEC and potentially translate into early disease recurrence. The aim of the present study is to identify possible correlations between IAP or CBT and postoperative complications...
December 29, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29284064/policies-for-biosimilar-uptake-in-europe-an-overview
#11
Evelien Moorkens, Arnold G Vulto, Isabelle Huys, Pieter Dylst, Brian Godman, Simon Keuerleber, Barbara Claus, Maria Dimitrova, Guenka Petrova, Ljiljana Sović-Brkičić, Juraj Slabý, Robin Šebesta, Ott Laius, Allan Karr, Morgane Beck, Jaana E Martikainen, Gisbert W Selke, Susan Spillane, Laura McCullagh, Gianluca Trifirò, Patricia Vella Bonanno, Asbjørn Mack, Antra Fogele, Anita Viksna, Magdalena Władysiuk, Helder Mota-Filipe, Dmitry Meshkov, Marija Kalaba, Simona Mencej Bedrač, Jurij Fürst, Corrine Zara, Peter Skiöld, Einar Magnússon, Steven Simoens
BACKGROUND: Across European countries, differences exist in biosimilar policies, leading to variations in uptake of biosimilars and divergences in savings all over Europe. OBJECTIVES: The aim of this article is to provide an overview of different initiatives and policies that may influence the uptake of biosimilars in different European countries. Recommendations will be formulated on how to create sustainable uptake. METHODS: An overview of policies on biosimilars was obtained via a questionnaire, supplemented with relevant articles...
2017: PloS One
https://www.readbyqxmd.com/read/29277690/correlations-between-fev1-and-patient-reported-outcomes-a-pooled-analysis-of-23-clinical-trials-in-patients-with-chronic-obstructive-pulmonary-disease
#12
REVIEW
James F Donohue, Paul W Jones, Christian Bartels, Jessica Marvel, Peter D'Andrea, Donald Banerji, David G Morris, Francesco Patalano, Robert Fogel
BACKGROUND: In clinical trials of inhaled bronchodilators, chronic obstructive pulmonary disease (COPD) guidelines recommend that patient-reported outcomes (PROs) are assessed alongside lung function. How these endpoints are related is unclear. METHODS: Pooled longitudinal data from 23 randomised controlled COPD studies were analyzed (N = 23,213). Treatments included long-acting β2 agonists, long-acting muscarinic antagonists (LABAs or LAMAs) and the LABA/LAMA combination QVA149...
December 19, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29277652/transient-synchronization-of-hippocampo-striato-thalamo-cortical-networks-during-sleep-spindle-oscillations-induces-motor-memory-consolidation
#13
Arnaud Boutin, Basile Pinsard, Arnaud Boré, Julie Carrier, Stuart M Fogel, Julien Doyon
Sleep benefits motor memory consolidation. This mnemonic process is thought to be mediated by thalamo-cortical spindle activity during NREM-stage2 sleep episodes as well as changes in striatal and hippocampal activity. However, direct experimental evidence supporting the contribution of such sleep-dependent physiological mechanisms to motor memory consolidation in humans is lacking. In the present study, we combined EEG and fMRI sleep recordings following practice of a motor sequence learning (MSL) task to determine whether spindle oscillations support sleep-dependent motor memory consolidation by transiently synchronizing and coordinating specialized cortical and subcortical networks...
December 22, 2017: NeuroImage
https://www.readbyqxmd.com/read/29273175/variability-in-state-based-recommendations-for-management-of-alpha-thalassemia-trait-and-silent-carrier-detected-on-the-newborn-screen
#14
Benjamin N Fogel, Hong Loan T Nguyen, Gayle Smink, Deepa L Sekhar
We conducted an inventory of state-based recommendations for follow-up of alpha thalassemia silent carrier and trait identified on newborn screen. We found wide variability in the nature and timing of these recommendations. We recommend a standardized recommendation to guide pediatricians in evidenced-based care for this population.
December 20, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29260216/benefits-and-risks-of-machine-learning-decision-support-systems
#15
LETTER
Alexander L Fogel, Joseph C Kvedar
No abstract text is available yet for this article.
December 19, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29237202/a-double-reprocessing-high-level-disinfection-protocol-does-not-eliminate-positive-cultures-from-the-elevators-of-duodenoscopes
#16
Douglas K Rex, Marnie Sieber, Glen A Lehman, Douglas Webb, Bryan Schmitt, Amy Beth Kressel, Ji Young Bang, Jeffery Easler, Lee McHenry, Ihab El-Hajj, Evan Fogel, James Watkins, Stuart Sherman
Background and study aim Duodenoscopes have been the source of serious infection, despite correct performance of high-level disinfection (HLD). This study aimed to observe the impact of performing HLD twice on the rate of positive cultures from duodenoscope elevators. Methods We performed double HLD (DHLD; i. e. complete manual cleaning followed by automated reprocessing, with the entire process repeated) and then randomly cultured the elevators of our duodenoscopes on about 30 % of occasions. Results DHLD was associated with positive elevator cultures for any microorganism in 9...
December 13, 2017: Endoscopy
https://www.readbyqxmd.com/read/29228952/association-between-left-ventricular-mechanics-and-diffuse-myocardial-fibrosis-in-patients-with-repaired-tetralogy-of-fallot-a-cross-sectional-study
#17
Christopher M Haggerty, Jonathan D Suever, Arichanah Pulenthiran, Abba Mejia-Spiegeler, Gregory J Wehner, Linyuan Jing, Richard J Charnigo, Brandon K Fornwalt, Mark A Fogel
BACKGROUND: Patients with repaired tetralogy of Fallot (TOF) have progressive, adverse biventricular remodeling, leading to abnormal contractile mechanics. Defining the mechanisms underlying this dysfunction, such as diffuse myocardial fibrosis, may provide insights into poor long-term outcomes. We hypothesized that left ventricular (LV) diffuse fibrosis is related to impaired LV mechanics. METHODS: Patients with TOF were evaluated with cardiac magnetic resonance in which modified Look-Locker (MOLLI) T1-mapping and spiral cine Displacement encoding (DENSE) sequences were acquired at three LV short-axis positions...
December 11, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29222741/exploratory-study-of-barriers-to-successful-office-contacts-for-attention-deficit-hyperactivity-disorder
#18
Jayde T Hooven, Benjamin N Fogel, James G Waxmonsky, Deepa L Sekhar
The American Academy of Pediatrics published attention deficit hyperactivity disorder (ADHD) guidelines, but significant variability exists in care. This exploratory study aimed to understand barriers to compliance with primary care office contacts for ADHD medication management. The study was conducted at a single academic medical center via retrospective chart review between 6/1/15 and 5/31/16 in combination with telephone interviews. Participants included 306 children 6-12 years old with an ADHD-related ICD-9/ICD-10 diagnosis...
December 8, 2017: Attention Deficit and Hyperactivity Disorders
https://www.readbyqxmd.com/read/29221774/sleep-dependent-motor-sequence-memory-consolidation-in-individuals-with-periodic-limb-movements
#19
Valya Sergeeva, Jeremy Viczko, Laura B Ray, Adrian M Owen, Stuart M Fogel
Periodic limb movements (PLMs) during sleep increase with age and are associated with striatal neurodegeneration and dopamine deficiency. Limb movements are often associated with disruptions to non-rapid eye movement (NREM) sleep. Motor skill memory consolidation recruits the striatum, and learning-dependent striatal activation is associated with NREM sleep. Therefore, we investigated whether de novo individuals who significantly experience elevated levels of PLMs but have not been formally diagnosed with periodic limb movement disorder had learning and sleep-related memory deficits and whether these deficits were related to sleep quality and symptom severity...
December 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29212315/post-ercp-bleeding-in-the-era-of-multiple-antiplatelet-agents
#20
Hyoung-Chul Oh, Ihab I El Hajj, Jeffrey J Easler, James Watkins, Evan L Fogel, Lee McHenry, Glen A Lehman, Jung Sik Choi, Hyun Kang, Stuart Sherman
Background/Aims: This study aimed to determine the risk of post-endoscopic retrograde cholangiopancreatography (post-ERCP) bleeding among patients taking antiplatelet agents (APAs), particularly in the era of multiple APAs. Methods: The primary outcomes were the frequency, type, and severity of ERCP-related bleeding according to the use of APAs. Results: The frequencies of post-ERCP bleeding among the four different groups were 16 of 2,083 (0...
December 8, 2017: Gut and Liver
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