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https://www.readbyqxmd.com/read/28087134/factors-influencing-and-modifying-the-decision-to-pursue-genetic-testing-for-skin-cancer-risk
#1
Alexander L Fogel, Prajakta D Jaju, Shufeng Li, Bonnie Halpern-Felsher, Jean Y Tang, Kavita Y Sarin
BACKGROUND: Across cancers, the decision to pursue genetic testing is influenced more by subjective than objective factors. However, skin cancer, which is more prevalent, visual, and multifactorial than many other malignancies, may offer different motivations for pursuing such testing. OBJECTIVES: The primary objective was to determine factors influencing the decision to receive genetic testing for skin cancer risk. A secondary objective was to assess the impact of priming with health questions on the decision to receive testing...
January 10, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28071654/responsiveness-of-endoscopic-indices-of-disease-activity-for-crohn-s-disease
#2
Reena Khanna, GuangYong Zou, Larry Stitt, Brian G Feagan, William J Sandborn, Paul Rutgeerts, John W D McDonald, Elena Dubcenco, Ronald Fogel, Remo Panaccione, Vipul Jairath, Sigrid Nelson, Lisa M Shackelton, Bidan Huang, Qian Zhou, Anne M Robinson, Barrett G Levesque, Geert D'Haens
OBJECTIVES: The Crohn's Disease Endoscopic Index of Severity (CDEIS) and the Simple Endoscopic Score for Crohn's Disease (SES-CD) are commonly used to assess Crohn's disease (CD) activity; however neither instrument is fully validated. We evaluated the responsiveness to change of the SES-CD and CDEIS using data from a trial of adalimumab, a drug therapy of known efficacy. METHODS: Paired video recordings (N=112) of colonoscopies (baseline and week 8-12) obtained from patients with CD who participated in a trial of adalimumab therapy were reviewed in random order, in duplicate, by four central readers (56 pairs of videos by 2 groups of readers)...
January 10, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28057210/epigenetic-changes-in-chronic-inflammatory-diseases
#3
O Fogel, C Richard-Miceli, J Tost
The number of people diagnosed with chronic inflammatory diseases has increased noteworthy in the last 40 years. Spondyloarthritis (SpA), inflammatory bowel diseases (IBD), and psoriasis are the most frequent chronic inflammatory diseases, resulting from a combination of genetic predisposition and environmental factors. Epigenetic modifications include DNA methylation, histone modifications, and small and long noncoding RNAs. They are influenced by environmental exposure, life-style, and aging and have recently been shown to be altered in many complex diseases including inflammatory diseases...
2017: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/28031423/neurologic-injury-and-cerebral-blood-flow-in-single-ventricles-throughout-staged-surgical-reconstruction
#4
Mark A Fogel, Christine J Li, Okan U Elci, Tom Pawlowski, Peter J Schwab, Felice B Wilson, Susan C Nicolson, Lisa M Montenegro, Laura Diaz, Thomas L Spray, J William Gaynor, Stephanie Fuller, Christopher E Mascio, Marc S Keller, Matthew A Harris, Kevin K Whitehead, James Bethel, Arastoo Vossough, Daniel J Licht
BACKGROUND: -Single ventricle patients experience a high rate of brain injury and adverse neurodevelopmental outcome, however, the incidence of brain abnormalities throughout surgical reconstruction and its relationship with cerebral blood flow, oxygen delivery and carbon dioxide reactivity remains unknown. METHODS: -Single ventricle patients were studied with MRI scans immediately prior to bidirectional Glenn (pre-BDG), prior to Fontan and then 3-9 months after Fontan reconstruction...
December 28, 2016: Circulation
https://www.readbyqxmd.com/read/28008244/indacaterol-glycopyrronium-in-symptomatic-patients-with-copd-gold-b-and-gold-d-versus-salmeterol-fluticasone-illuminate-lantern-pooled-analysis
#5
Claus Vogelmeier, Nanshan Zhong, Michael J Humphries, Karen Mezzi, Robert Fogel, Giovanni Bader, Francesco Patalano, Donald Banerji
BACKGROUND: Indacaterol/glycopyrronium (IND/GLY) is approved for maintenance treatment of adult patients with COPD. This post hoc analysis explored the efficacy and safety of IND/GLY versus salmeterol/fluticasone (SFC) in symptomatic (Global Initiative for Chronic Obstructive Lung Disease [GOLD] B and GOLD D) patients with moderate-to-severe COPD. PATIENTS AND METHODS: Data from LANTERN and ILLUMINATE studies were pooled and analyzed. In both studies, symptomatic COPD patients were randomized to once-daily IND/GLY 110 μg/50 μg or twice-daily SFC 50 μg/500 μg...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28003094/ecological-correlations-of-dietary-food-intake-and-mental-health-disorders
#6
Jordan Hoerr, Joshua Fogel, Benjamin Van Voorhees
This paper examines the ecological association of dietary food intake with mental health outcomes on the group level across countries. Published data from the World Mental Health Survey were used to compare lifetime prevalence of four categories of mental health disorders (anxiety disorders, mood disorders, impulse control disorders, and substance use disorders) with a country's fish/seafood and sugar/sweetener supply quantity using the Spearman rank correlation. Data were compared for 17 countries across the world...
December 18, 2016: Journal of Epidemiology and Global Health
https://www.readbyqxmd.com/read/27984444/advanced-imaging-lacks-clinical-utility-in-treating-geriatric-pelvic-ring-injuries-caused-by-low-energy-trauma
#7
Roman M Natoli, Harold A Fogel, Daniel Holt, Adam Schiff, Mitchell Bernstein, Hobie D Summers, William Lack
OBJECTIVES: Is advanced imaging necessary in evaluation of pelvic fractures caused by low energy trauma in elderly patients? DESIGN: Retrospective review SETTING:: Single institution, Level 1 Trauma Center PATIENTS:: Age ≥ 60 years old treated for low energy traumatic pelvic ring injuries INTERVENTION:: None MAIN OUTCOMES:: Posterior pelvic ring injuries diagnosed on advanced imaging, radiographic displacement, admission status, hospital length of stay, change in weight-bearing status recommendations, and whether operative treatment was pursued RESULTS:: Eighty-seven patients met the inclusion criteria of which 42 had advanced imaging to evaluate the posterior pelvic ring (10 MRIs, 32 CTs)...
November 24, 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27981804/md-logic-overnight-type-1-diabetes-control-in-home-settings-multicenter-multinational-single-blind-randomized-trial
#8
Revital Nimri, Natasa Bratina, Olga Kordonouri, Magdalena Avbelj Stefanija, Maryam Fath, Torben Biester, Ido Muller, Eran Atlas, Shahar Miller, Aviel Fogel, Moshe Phillip, Thomas Danne, Tadej Battelino
AIMS: To evaluate the safety, efficacy and need for remote-monitoring of the MD-logic closed-loop system during short term overnight use at home. METHODS: Seventy-five patients (38 males; aged 10-54 years; average A1c 7.8 ± 0.7%, 61.8 ± 7.2 mmol/mol) were enrolled from three clinical sites. Patients were randomly assigned to participate in two overnight crossover periods, each including 4 consecutive nights, one under closed-loop and the second under sensor-augmented pump (SAP) therapy in the patient's home...
December 16, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27932945/monoaminergic-and-histaminergic-strategies-and-treatments-in-brain-diseases
#9
REVIEW
Giuseppe Di Giovanni, Dubravka Svob Strac, Montse Sole, Mercedes Unzeta, Keith F Tipton, Dorotea Mück-Šeler, Irene Bolea, Laura Della Corte, Matea Nikolac Perkovic, Nela Pivac, Ilse J Smolders, Anna Stasiak, Wieslawa A Fogel, Philippe De Deurwaerdère
The monoaminergic systems are the target of several drugs for the treatment of mood, motor and cognitive disorders as well as neurological conditions. In most cases, advances have occurred through serendipity, except for Parkinson's disease where the pathophysiology led almost immediately to the introduction of dopamine restoring agents. Extensive neuropharmacological studies first showed that the primary target of antipsychotics, antidepressants, and anxiolytic drugs were specific components of the monoaminergic systems...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27914300/structure-based-analysis-of-bacilli-and-plasmid-dihydrofolate-reductase-evolution
#10
Mona Alotaibi, Ben Delos Reyes, Tin Le, Phuong Luong, Faramarz Valafar, Robert P Metzger, Gary B Fogel, David Hecht
Dihydrofolate reductase (DHFR), a key enzyme in tetrahydrofolate-mediated biosynthetic pathways, has a structural motif known to be highly conserved over a wide range of organisms. Given its critical role in purine and amino acid synthesis, DHFR is a well established therapeutic target for treating a wide range of prokaryotic and eukaryotic infections as well as certain types of cancer. Here we present a structural-based computer analysis of bacterial (Bacilli) and plasmid DHFR evolution. We generated a structure-based sequence alignment using 7 wild-type DHFR x-ray crystal structures obtained from the RCSB Protein Data Bank and 350 chromosomal and plasmid homology models we generated from sequences obtained from the NCBI Protein Database...
January 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/27911111/outcomes-of-scleral-buckle-removal-experience-from-the-last-decade
#11
Elad Moisseiev, Miri Fogel, Ido Didi Fabian, Adiel Barak, Joseph Moisseiev, Amir Alhalel
PURPOSE: To evaluate the indications, outcomes, and complications of scleral buckle removal over the past decade and compare to previously published data. METHODS: Forty nine eyes of 49 patients who underwent scleral buckle removal and had at least 6 months of follow-up were included in this retrospective study. Recorded parameters included demographic information, history of the retinal detachment, details of the scleral buckling surgery, indication for scleral buckle removal, time from scleral buckle placement to removal, culture results, length of follow up, visual acuity (VA) throughout the follow up, and the occurrence of any complications or need for additional surgery after scleral buckle removal...
December 2, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27891070/monoaminergic-mechanisms-in-epilepsy-may-offer-innovative-therapeutic-opportunity-for-monoaminergic-multi-target-drugs
#12
REVIEW
Dubravka Svob Strac, Nela Pivac, Ilse J Smolders, Wieslawa A Fogel, Philippe De Deurwaerdere, Giuseppe Di Giovanni
A large body of experimental and clinical evidence has strongly suggested that monoamines play an important role in regulating epileptogenesis, seizure susceptibility, convulsions, and comorbid psychiatric disorders commonly seen in people with epilepsy (PWE). However, neither the relative significance of individual monoamines nor their interaction has yet been fully clarified due to the complexity of these neurotransmitter systems. In addition, epilepsy is diverse, with many different seizure types and epilepsy syndromes, and the role played by monoamines may vary from one condition to another...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27886854/efficacy-and-safety-of-indacaterol-glycopyrronium-in-japanese-patients-with-copd-pooled-analysis-of-shine-and-arise
#13
Kazuhisa Asai, Kazuto Hirata, Shu Hashimoto, Yoshinosuke Fukuchi, Tetsuji Kitawaki, Kimitoshi Ikeda, Robert Fogel, Donald Banerji
BACKGROUND: To better evaluate the efficacy and safety of the indacaterol/glycopyrronium (IND/GLY) fixed-dose combination versus tiotropium in Japanese patients, a pooled data analysis was conducted from the SHINE and ARISE studies, which were part of the IND/GLY clinical trial program. METHODS: Japanese patients with moderate-to-severe COPD were included in the analysis. Efficacy in terms of pre-dose forced expiratory volume in one second (FEV1) at Week 12 and Week 24/26 (ARISE/SHINE) and FEV1 at 30min and 60min post-dose at Day 1, Week 12, and Week 24/26 was evaluated...
November 2016: Respiratory Investigation
https://www.readbyqxmd.com/read/27855985/can-time-averaged-flow-boundary-conditions-be-used-to-meet-the-clinical-timeline-for-fontan-surgical-planning
#14
Zhenglun Alan Wei, Phillip M Trusty, Mike Tree, Christopher M Haggerty, Elaine Tang, Mark Fogel, Ajit P Yoganathan
Cardiovascular simulations have great potential as a clinical tool for planning and evaluating patient-specific treatment strategies for those suffering from congenital heart diseases, specifically Fontan patients. However, several bottlenecks have delayed wider deployment of the simulations for clinical use; the main obstacle is simulation cost. Currently, time-averaged clinical flow measurements are utilized as numerical boundary conditions (BCs) in order to reduce the computational power and time needed to offer surgical planning within a clinical time frame...
January 4, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/27849650/programmed-cell-death-ligand-1-pd-l1-expression-in-anal-cancer
#15
Rangaswamy Govindarajan, Swetha Gujja, Eric R Siegel, Anu Batra, Anwaar Saeed, Keith Lai, Jennifer D James, Bradley J Fogel, Stephen Williamson
OBJECTIVE: To evaluate the expression of programmed cell death-ligand 1 (PD-L1) in anal cancer. PATIENTS AND METHODS: In a retrospective cohort analysis, subjects with squamous cell carcinoma of the anal canal were tested for PD-L1 expression, then followed for recurrence and survival. Crude recurrence rates (CRRs), crude mortality rates (CMRs), and crude event rates (CERs) were assessed for PD-L1-dependent differences using Poisson regression. All 3 types of crude rate were expressed as the number that occurred per hundred person-years (hPY) of follow-up...
November 15, 2016: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27837302/longitudinal-validation-of-the-diastolic-to-systolic-time-velocity-integral-ratio-as-a-doppler-derived-measure-of-pulmonary-regurgitation-in-patients-with-repaired-tetralogy-of-fallot
#16
Misha Bhat, Elizabeth Goldmuntz, Mark A Fogel, Jack Rychik, Laura Mercer-Rosa
Pulmonary regurgitation (PR) is a common residual lesion and major determinant of outcome following surgical repair for tetralogy of Fallot. We sought to longitudinally study a previously described echocardiographic index as a correlate of PR measured by cardiac magnetic resonance imaging (CMR). We conducted a retrospective longitudinal study of patients with baseline and follow-up echocardiogram and CMR. The baseline studies were obtained as part of a research protocol, while the follow-up studies were performed for clinical purposes...
November 11, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27828875/antiretroviral-drug-use-in-a-cross-sectional-population-survey-in-africa-nimh-project-accept-hptn-043
#17
Jessica M Fogel, William Clarke, Michal Kulich, Estelle Piwowar-Manning, Autumn Breaud, Matthew T Olson, Mark A Marzinke, Oliver Laeyendecker, Agnès Fiamma, Deborah Donnell, Jessie K K Mbwambo, Linda Richter, Glenda Gray, Michael Sweat, Thomas J Coates, Susan H Eshleman
BACKGROUND: Antiretroviral (ARV) drug treatment benefits the treated individual and can prevent HIV transmission. We assessed ARV drug use in a community-randomized trial that evaluated the impact of behavioral interventions on HIV incidence. METHODS: Samples were collected in a cross-sectional survey after a 3-year intervention period. ARV drug testing was performed using samples from HIV-infected adults at 4 study sites (Zimbabwe; Tanzania; KwaZulu-Natal and Soweto, South Africa; survey period 2009-2011) using an assay that detects 20 ARV drugs (6 nucleoside/nucleotide reverse transcriptase inhibitors, 3 nonnucleoside reverse transcriptase inhibitors, and 9 protease inhibitors; maraviroc; raltegravir)...
February 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27824485/the-value-of-secretin-enhanced-mrcp-in-patients-with-recurrent-acute-pancreatitis
#18
Kumar Sandrasegaran, Bilal Tahir, Udaykamal Barad, Evan Fogel, Fatih Akisik, Temel Tirkes, Stuart Sherman
OBJECTIVE: The purpose of this study is to assess the additional value of secretin-enhanced MRCP over conventional (non-secretin-enhanced) MRCP in diagnosing disease in patients with recurrent acute pancreatitis. MATERIALS AND METHODS: A retrospective review of a radiology database found 72 patients with recurrent acute pancreatitis who had secretin-enhanced MRCP and ERCP correlation within 3 months of each other between January 2007 and December 2011. Of these patients, 54 had no history of pancreatic tumor or surgery and underwent MRI more than 3 months after an episode of acute pancreatitis...
November 8, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27815989/sleep-spindles-a-physiological-marker-of-age-related-changes-in-gray-matter-in-brain-regions-supporting-motor-skill-memory-consolidation
#19
Stuart Fogel, Catherine Vien, Avi Karni, Habib Benali, Julie Carrier, Julien Doyon
Sleep is necessary for the optimal consolidation of procedural learning, and in particular, for motor sequential skills. Motor sequence learning remains intact with age, but sleep-dependent consolidation is impaired, suggesting that memory deficits for procedural skills are specifically impacted by age-related changes in sleep. Age-related changes in spindles may be responsible for impaired motor sequence learning consolidation, but the morphological basis for this deficit is unknown. Here, we found that gray matter in the hippocampus and cerebellum was positively correlated with both sleep spindles and offline improvements in performance in young participants but not in older participants...
January 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/27815538/european-heart-rhythm-association-ehra-european-association-of-cardiovascular-prevention-and-rehabilitation-eacpr-position-paper-on-how-to-prevent-atrial-fibrillation-endorsed-by-the-heart-rhythm-society-hrs-and-asia-pacific-heart-rhythm-society-aphrs
#20
Bulent Gorenek Chair, Antonio Pelliccia Co-Chair, Emelia J Benjamin, Giuseppe Boriani, Harry J Crijns, Richard I Fogel, Isabelle C Van Gelder, Martin Halle, Gulmira Kudaiberdieva, Deirdre A Lane, Torben Bjerregaard Larsen, Gregory Y H Lip, Maja-Lisa Løchen, Francisco Marin, Josef Niebauer, Prashanthan Sanders, Lale Tokgozoglu, Marc A Vos, David R Van Wagoner, Laurent Fauchier, Irina Savelieva, Andreas Goette, Stefan Agewall, Chern-En Chiang, Márcio Figueiredo, Martin Stiles, Timm Dickfeld, Kristen Patton, Massimo Piepoli, Ugo Corra, Pedro Manuel Marques-Vidal, Pompilio Faggiano, Jean-Paul Schmid, Ana Abreu
No abstract text is available yet for this article.
January 2017: European Journal of Preventive Cardiology
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