Giulia Brigante, Daniele Santi, Gisella Boselli, Gianluca Margiotta, Rossella Corleto, Maria Laura Monzani, Andrea Craparo, Michela Locaso, Samantha Sperduti, Neena Roy, Livio Casarini, Tommaso Trenti, Simonetta Tagliavini, Maria Cristina De Santis, Laura Roli, Vincenzo Rochira, Manuela Simoni
OBJECTIVE: Despite having normal thyroid-stimulating hormone levels, many hypothyroid patients are dissatisfied with the treatment. The primary aim of this study was to evaluate the effect of twice-daily, combination therapy with levothyroxine (LT4) and liothyronine (LT3), at doses adapted according to TSH-level, on peripheral tissues as reflected by sex hormone binding globulin (SHBG) levels in totally thyroidectomized patients. Changes in other tissue markers and quality of life considering DIO2-rs225014 and MCT10-rs17606253 genetic variants were also assessed...
January 3, 2024: European Journal of Endocrinology