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https://www.readbyqxmd.com/read/29334211/curcumin-and-quercetin-ameliorated-cypermethrin-and-deltamethrin-induced-reproductive-system-impairment-in-male-wistar-rats-by-upregulating-the-activity-of-pituitary-gonadal-hormones-and-steroidogenic-enzymes
#1
Poonam Sharma, Irshad Aslam Khan, Rambir Singh
Background: Dietary antioxidants protect tissues and organs against insecticides/xenobiotic-induced damage. In the present study, we evaluated the results of exposure to synthetic pyrethroid insecticides, cypermethrin (Cyp) and deltamethrin (Del) and possible protective effects of curcumin and quercetin on reproductive system in male Wistar rats. MATERIALS AND METHODS: In this controlled experimental study, 42 male Wistar rats were randomly divided into 7 groups of 6 animals...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29283676/the-effect-of-solithromycin-a-cationic-amphiphilic-drug-on-the-proliferation-and-differentiation-of-human-meibomian-gland-epithelial-cells
#2
Yang Liu, Wendy R Kam, Prabhavathi Fernandes, David A Sullivan
PURPOSE: We previously discovered that azithromycin (AZM) acts directly on immortalized human meibomian gland epithelial cells (IHMGECs) to stimulate their lipid and lysosome accumulation and overall differentiation. We hypothesize that this phospholipidosis-like effect is due to AZM's cationic amphiphilic drug (CAD) nature. If our hypothesis is correct, then other CADs (e.g., solithromycin [SOL]) should be able to duplicate AZM's action on IHMGECs. Our purpose was to test this hypothesis...
December 28, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29203053/insulin-like-growth-factor-1-mediates-adrenal-development-dysfunction-in-offspring-rats-induced-by-prenatal-food-restriction
#3
Zheng He, Feng Lv, Yufeng Ding, Chunyan Zhu, Hegui Huang, Li Zhang, Yu Guo, Hui Wang
BACKGROUND: Our previous study demonstrated that prenatal food restriction (PFR) could induce the dysfunction of the hypothalamic-pituitary-adrenal axis and glucocorticoid-related glucose and lipid metabolic alterations in adult offspring rats. AIM OF THE STUDY: To investigate the intrauterine programming mechanism of adrenal dysfunction in the PFR offspring rats. METHODS: From gestational days (GDs) 11-20, pregnant Wistar rats were fed a restricted diet (50% of the daily food intake of control rats, 60 g/kg·d)...
December 1, 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/29169197/sex-dependent-effect-of-metformin-on-serum-prolactin-levels-in-hyperprolactinemic-patients-with-type-2-diabetes-a-pilot-study
#4
Robert Krysiak, Witold Szkróbka, Bogusław Okopień
Background Metformin was found to reduce circulating levels of pituitary hormones. Objective The purpose of this study was to assess whether sex determines the effect of metformin on lactotroph secretory function. Methods The study population included 25 women and 12 men with mildly elevated serum prolactin levels (25-75 ng/mL). Because of concomitant type 2 diabetes, all participants were treated with metformin (3 g daily). Plasma levels of glucose and lipids, HOMA1-IR, serum levels of prolactin, thyrotropin and free thyroid hormones, as well as Jostel's, SPINA-GT and SPINA-GD indices were assessed at baseline and at the end of metformin treatment...
November 23, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29144802/lipid-accumulation-product-visceral-adiposity-index-and-chinese-visceral-adiposity-index-as-markers-of-cardiometabolic-risk-in-adult-growth-hormone-deficiency-patients-a-cross-sectional-study
#5
Xin Xie, Qing Li, Lingmin Zhang, Wei Ren
OBJECTIVE: Adult growth hormone deficiency (AGHD) is associated with cardiometabolic risk factors. Given that cardiovascular disease (CVD) is an important cause of morbidity and mortality in the AGHD population, there is a need for alternative, non-invasive methods of assessing cardiometabolic risk in this population. Chinese visceral adiposity index (CVAI) is a new marker of visceral fat dysfunction that is based on age, body mass index (BMI), waist circumference (WC) and metabolic parameters...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29136956/antagonistic-effect-of-oxytocin-and-tacrolimus-combination-on-adipose-tissue-derived-mesenchymal-stem-cells-antagonistic-effect-of-oxytocin-and-tacrolimus-antagonistic-effect-of-oxytocin-and-tacrolimus
#6
Gozde Sir, Bakiye Goker Bagca, Gurkan Yigitturk, Turker Cavusoglu, Cigir Biray Avci, Cumhur Gunduz, Yigit Uyanikgil
Tacrolimus (FK506) is a chemotherapeutic agent, which uses calcineurin pathway via inhibiting the stimulation of T cells to prevent the formation of immune response in the recipient individual in organ transplants. FK506 is mainly metabolized in the liver by cytochrome P450 enzyme system and is known that it has high toxic effects on different cells. Mesenchymal stem cells (MSCs) have recently gained importance since their potential to be used in cellular therapy and tissue regeneration. In some clinical cases, MSCs are transferred into the patient after the organ transplantations in order to support the treatment...
November 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29118400/differential-transcriptome-regulation-by-3-5-t2-and-3-3-5-t3-in-brain-and-liver-uncovers-novel-roles-for-thyroid-hormones-in-tilapia
#7
A Olvera, C J Martyniuk, N Buisine, V Jiménez-Jacinto, A Sanchez-Flores, L M Sachs, A Orozco
Although 3,5,3'-triiodothyronine (T3) is considered to be the primary bioactive thyroid hormone (TH) due to its high affinity for TH nuclear receptors (TRs), new data suggest that 3,5-diiodothyronine (T2) can also regulate transcriptional networks. To determine the functional relevance of these bioactive THs, RNA-seq analysis was conducted in the cerebellum, thalamus-pituitary and liver of tilapia treated with equimolar doses of T2 or T3. We identified a total of 169, 154 and 2863 genes that were TH-responsive (FDR < 0...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29089885/repetitive-transcranial-magnetic-stimulation-rtms-modulates-lipid-metabolism-in-aging-adults
#8
Weicong Ren, Jiang Ma, Juan Li, Zhijie Zhang, Mingwei Wang
Hyperlipidemia, one of the cardiovascular (CV) risk factors, is associated with an increase in the risk for dementia. Repetitive transcranial magnetic stimulation (rTMS) was applied over the right dorsolateral prefrontal cortex (DLPFC) to modulate serum lipid levels in older adults. Participants received 10 sessions of rTMS or sham stimulation intervention within 2 weeks. The serum lipid and thyroid hormone-related endocrine levels were assessed before and after the treatment. We found that rTMS significantly decreased serum lipid levels, including the total cholesterol (CHO) and triglyceride (TG); meanwhile, it also increased the thyroid-stimulating hormone (TSH) as well as thyroxine (T4) levels...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29070768/effect-of-growth-hormone-replacement-therapy-on-plasma-diacron-reactive-oxygen-metabolites-and-endothelial-function-in-japanese-patients-the-great-clinical-study
#9
Kunihiro Suzuki, Kazunori Yanagi, Masanori Shimizu, Sho Wakamatsu, Takafumi Niitani, Soichiro Hosonuma, Masaaki Sagara, Yoshimasa Aso
Patients with growth hormone deficiency (GHD) have an increased risk of atherosclerosis and vascular mortality. Evidence suggests that endothelial dysfunction is involved in all stages of atherogenesis. This study examined the effect of growth hormone (GH) replacement therapy on diacron-reactive oxygen metabolites (d-ROMs) and endothelial function in Japanese patients with GHD, using peripheral arterial tonometry. This was an open-label, prospective, case-control study. Nine patients with GHD who had not previously received any GH replacement therapy were enrolled...
October 25, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29065123/supplemental-arginine-vasopressin-during-the-resuscitation-of-severe-hemorrhagic-shock-preserves-renal-mitochondrial-function
#10
Carrie A Sims, Guan Yuxia, Khushboo Singh, Evan C Werlin, Patrick M Reilly, Joseph A Baur
Arginine vasopressin (AVP), a hormone secreted by the posterior pituitary, plays a vital role in maintaining vasomotor tone during acute blood loss. We hypothesized that decompensated hemorrhagic shock is associated with decreased AVP stores and supplementation during resuscitation would improve both blood pressure and renal function. Using a decompensated hemorrhagic shock model, male Long-Evans rats were bled to mean arterial blood pressure (MAP) of 40mmHg and maintained until the MAP could not be sustained without fluid...
2017: PloS One
https://www.readbyqxmd.com/read/29063103/influence-of-insulin-on-growth-hormone-secretion-level-and-growth-hormone-signalling
#11
Han Qiu, Jin-Kui Yang, Chen Chen
Growth hormone (GH), as a vital hormone, has to experience a series of processes to fulfill its function including secretion, entering the circulation to reach target tissues (pre-receptor process), binding on the GH receptor (GHR) and triggering signaling inside cells (post-GHR process). Insulin can directly or indirectly influence part of these processes. GH secretion from pituitary somatotropes is regulated by GH-releasing hormone (GHRH) and somatostatin (SS) from hypothalamus. Insulin may exert positive or negative effects on the neurons expressing GHRH and SS and somatotropes under healthy and pathological conditions including obesity and diabetes...
October 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/29025979/the-melatonin-receptor-agonist-piromelatine-ameliorates-impaired-glucose-metabolism-in-chronically-stressed-rats-fed-a-high-fat-diet
#12
Jun Zhou, Deng Wang, Xiaohong Luo, Xu Jia, Maoxing Li, Laudon Moshe, Ruxue Zhang, Zhengping Jia
Modern lifestyle factors (high-caloric food rich in fat) and daily chronic stress are important risk factors for metabolic disturbances. Increased hypothalamic-pituitary-adrenal (HPA) axis activity and the subsequent excess production of glucocorticoids (GCs) in response to chronic stress (CS) leads to increases in metabolic complications, such as type 2 diabetes and insulin resistance (IR). Melatonin (MLT), which protects several regulatory components of the HPA axis from GC-induced deterioration, might improve glucose homeostasis...
October 12, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28911811/an-intergenerational-effect-of-neuroendocrine-metabolic-programming-alteration-induced-by-prenatal-ethanol-exposure-in-rats
#13
Hao Kou, Lang Shen, Han-Wen Luo, Liao-Bin Chen, Dong-Fang Wu, Hui Wang
Prenatal ethanol exposure (PEE) induces hypothalamic-pituitary-adrenal (HPA) axis-related neuroendocrine metabolic programming alteration in the first generation (F1) rats. In this study, the HPA hormones and glucose/lipid phenotypes under basal state and stressed condition induced by a fortnight ice-water swimming were examined in F2 to verify the intergenerational effect. Under the basal state, serum corticosterone (CORT) and glucose of some PEE groups were lowered while those of serum triglycerides (TG) were increased comparing with controls...
September 12, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28910603/apolipoprotein-a-iv-constrains-hpa-and-behavioral-stress-responsivity-in-a-strain-dependent-manner
#14
Amy E B Packard, Jintao Zhang, Brent Myers, Chih-Wei Ko, Fei Wang, Patrick Tso, Yvonne M Ulrich-Lai
There is a critical gap in our knowledge of the mechanisms that govern interactions between daily life experiences (e.g., stress) and metabolic diseases, despite evidence that stress can have profound effects on cardiometabolic health. Apolipoprotein A-IV (apoA-IV) is a protein found in chylomicrons (lipoprotein particles that transport lipids throughout the body) where it participates in lipid handling and the regulation of peripheral metabolism. Moreover, apoA-IV is expressed in brain regions that regulate energy balance including the arcuate nucleus...
December 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28827316/rnf20-suppresses-tumorigenesis-by-inhibiting-srebp1c-pttg1-axis-in-kidney-cancer
#15
Jae Ho Lee, Yong Geun Jeon, Kyoung-Hwa Lee, Hye Won Lee, Jeu Park, Hagoon Jang, Minyong Kang, Hye Sun Lee, Hee Jin Cho, Do-Hyun Nam, Cheol Kwak, Jae Bum Kim
Elevated lipid metabolism promotes cancer cell proliferation. Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancers, characterized by ectopic lipid accumulation. However, the relationship between aberrant lipid metabolism and tumorigenesis in ccRCC is not thoroughly understood. Here, we demonstrate that ring finger protein 20 (RNF20) acts as a tumor suppressor in ccRCC. RNF20 overexpression repressed lipogenesis and cell proliferation by inhibiting sterol regulatory element-binding protein 1c (SREBP1c), and SREBP1 suppression by either knockdown or the pharmacological inhibitor betulin attenuated proliferation and cell cycle progression in ccRCC cells...
August 21, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28808144/particulate-matter-exposure-and-stress-hormone-levels-a-randomized-double-blind-crossover-trial-of-air-purification
#16
RANDOMIZED CONTROLLED TRIAL
Huichu Li, Jing Cai, Renjie Chen, Zhuohui Zhao, Zhekang Ying, Lin Wang, Jianmin Chen, Ke Hao, Patrick L Kinney, Honglei Chen, Haidong Kan
BACKGROUND: Exposure to ambient particulate matter (PM) is associated with a number of adverse health outcomes, but potential mechanisms are largely unknown. Metabolomics represents a powerful approach to study global metabolic changes in response to environmental exposures. We therefore conducted this study to investigate changes in serum metabolites in response to the reduction of PM exposure among healthy college students. METHODS: We conducted a randomized, double-blind crossover trial in 55 healthy college students in Shanghai, China...
August 15, 2017: Circulation
https://www.readbyqxmd.com/read/28780396/mobile-phone-1800mhz-radiation-impairs-female-reproduction-in-mice-mus-musculus-through-stress-induced-inhibition-of-ovarian-and-uterine-activity
#17
Saba Shahin, Surya Pal Singh, Chandra Mohini Chaturvedi
Present study investigated the long-term effects of mobile phone (1800MHz) radiation in stand-by, dialing and receiving modes on the female reproductive function (ovarian and uterine histo-architecture, and steroidogenesis) and stress responses (oxidative and nitrosative stress). We observed that mobile phone radiation induces significant elevation in ROS, NO, lipid peroxidation, total carbonyl content and serum corticosterone coupled with significant decrease in antioxidant enzymes in hypothalamus, ovary and uterus of mice...
August 2, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28763303/insights-into-the-potential-antidepressant-mechanisms-of-cilostazol-in-chronically-restraint-rats-impact-on-the-nrf2-pathway
#18
Sally A Abuelezz, Nevien Hendawy
Ample evidence has pointed to a close link between oxidative stress, mitochondrial dysfunction, and depression. Nuclear factor-erythroid 2-related factor-2 (Nrf2) is a master regulator of cellular redox homeostasis and affects mitochondrial function. Nrf2 holds promise for depression prevention and treatment. This study aimed to investigate the potential prophylactic antidepressant effect of cilostazol and the contribution of the Nrf2 pathway toward the putative neuroprotection. The behavioral and neurochemical effects of concomitant treatment of oral cilostazol at doses of 7...
July 31, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28751271/early-child-adversity-and-psychopathology-in-adulthood-hpa-axis-and-cognitive-dysregulations-as-potential-mechanisms
#19
REVIEW
Catherine Raymond, Marie-France Marin, Danie Majeur, Sonia Lupien
Early adversity (EA) has been shown to be a potent risk factor for developing a psychopathology in adulthood. Alterations of the stress system in addition to changes in brain development have been suggested to explain some of the psychopathologies associated with EA. The stress response involves the activation of the hypothalamic-pituitary-adrenal (HPA)-axis, which leads to the production of glucocorticoids (GCs; cortisol in humans). Being soluble in lipids, GCs easily cross the blood brain barrier and access GC receptors in the hippocampus, prefrontal cortex and amygdala...
July 25, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28729344/exogenous-stress-hormones-alter-energetic-and-nutrient-costs-of-development-and-metamorphosis
#20
Lucas J Kirschman, Marshall D McCue, Justin G Boyles, Robin W Warne
Variation in environmental conditions during larval life stages can shape development during critical windows and have lasting effects on the adult organism. Changes in larval developmental rates in response to environmental conditions, for example, can trade-off with growth to determine body size and condition at metamorphosis, which can affect adult survival and fecundity. However, it is unclear how use of energy and nutrients shape trade-offs across life stage transitions because no studies have quantified these costs of larval development and metamorphosis...
July 20, 2017: Journal of Experimental Biology
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