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https://www.readbyqxmd.com/read/28623763/saturated-high-fat-feeding-independent-of-obesity-alters-hypothalamus-pituitary-adrenal-axis-function-but-not-anxiety-like-behaviour
#1
Cecile Hryhorczuk, Léa Décarie-Spain, Sandeep Sharma, Caroline Daneault, Christine Des Rosiers, Thierry Alquier, Stephanie Fulton
Overconsumption of dietary fat can elicit impairments in emotional processes and the response to stress. While excess dietary lipids have been shown to alter hypothalamus-pituitary-adrenal (HPA) axis function and promote anxiety-like behaviour, it is not known if such changes rely on elevated body weight and if these effects are specific to the type of dietary fat. The objective of this study was to investigate the effect of a saturated and a monounsaturated high-fat diet (HFD) on HPA axis function and anxiety-like behaviour in rats...
June 10, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28612976/lithium-ameliorates-sleep-deprivation-induced-mania-like-behavior-hypothalamic-pituitary-adrenal-hpa-axis-alterations-oxidative-stress-and-elevations-of-cytokine-concentrations-in-the-brain-and-serum-of-mice
#2
Samira S Valvassori, Wilson R Resende, Gustavo Dal-Pont, Heron Sangaletti-Pereira, Fernanda F Gava, Bruna R Peterle, Roger B Varela, Felipe Dal-Pizzol, João Quevedo
OBJECTIVES: The goal of the present study was to investigate the effects of lithium administration on behavior, oxidative stress parameters and cytokine levels in the periphery and brain of mice subjected to an animal model of mania induced by paradoxical sleep deprivation (PSD). METHODS: Male C57 mice were treated with saline or lithium for 7 days. The sleep deprivation protocol started on the 5th day during for the last 36 hours of the treatment period. Immediately after the sleep deprivation protocol, animals locomotor activity was evaluated and serum and brain samples was extracted to evaluation of corticosterone and adrenocorticotropic hormone circulating levels, oxidative stress parameters and citokynes levels...
June 14, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28599146/maternal-lipids-in-pregnancy-are-associated-with-increased-offspring-cortisol-reactivity-in-childhood
#3
Theresia H Mina, Marius Lahti, Amanda J Drake, Shareen Forbes, Fiona C Denison, Katri Räikkönen, Jane E Norman, Rebecca M Reynolds
Prenatal programming of hypothalamic-pituitary-adrenal (HPA) axis activity has long term implications for offspring health. Biological mechanisms underlying programming of the offspring HPA axis are poorly understood. We hypothesised that altered maternal metabolism including higher maternal obesity, glucose and lipids are novel programming factors for altered offspring HPA axis activity. Salivary cortisol levels were measured in 54 children aged 3-5 years under experimental conditions (before and after a delay of self-gratification test)...
May 31, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28586412/high-fat-diet-and-female-fertility
#4
Natalie M Hohos, Malgorzata E Skaznik-Wikiel
The prevalence of obesity is high among reproductive age women and is associated with impaired reproductive function. Obesity is multifactorial in origin, yet many cases of obesity result from overconsumption of a diet high in fat. Excess dietary fat increases both adipose and non-adipose tissue lipid content, and through lipotoxicity leads to cell dysfunction and death. High dietary fat intake, with or without the development of obesity, impairs female hypothalamic-pituitary-ovarian (HPO) axis functionality and fertility...
June 6, 2017: Endocrinology
https://www.readbyqxmd.com/read/28552719/regulation-of-longevity-by-fgf21-interaction-between-energy-metabolism-and-stress-responses
#5
REVIEW
Antero Salminen, Kai Kaarniranta, Anu Kauppinen
Fibroblast growth factor 21 (FGF21) is a hormone-like member of FGF family which controls metabolic multiorgan crosstalk enhancing energy expenditure through glucose and lipid metabolism. In addition, FGF21 acts as a stress hormone induced by endoplasmic reticulum stress and dysfunctions of mitochondria and autophagy in several tissues. FGF21 also controls stress responses and metabolism by modulating the functions of somatotropic axis and hypothalamic-pituitary-adrenal (HPA) pathway. FGF21 is a potent longevity factor coordinating interactions between energy metabolism and stress responses...
May 25, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28552377/influence-of-water-salinity-on-genes-implicated-in-somatic-growth-lipid-metabolism-and-food-intake-in-pejerrey-odontesthes-bonariensis
#6
Juan Ignacio Bertucci, Mario Oswaldo Tovar, Ayelén Melisa Blanco, Pedro Gómez-Requeni, Suraj Unniappan, Luis Fabián Canosa
Pejerrey, Odontesthes bonariensis, is an euryhaline fish of commercial importance in Argentina. This work aimed to determine if water salinity affects the expression of genes involved in somatic growth (gh; ghr-I; ghr-II; igf-I), lipid metabolism (Δ6-desaturase) and food intake (nucb2/nesfatin-1). First, we identified the full-length cDNA sequences of Δ6-desaturase (involved in lipid metabolism) and nesfatin-1 (an anorexigen). Then, pejerrey juveniles were reared during 8weeks in three different water salinity conditions: 2...
May 26, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28541489/respiratory-effects-and-systemic-stress-response-following-acute-acrolein-inhalation-in-rats
#7
Samantha J Snow, Marie A McGee, Andres Henriquez, Judy E Richards, Mette C Schladweiler, Allen D Ledbetter, Urmila P Kodavanti
Previous studies have demonstrated that exposure to the pulmonary irritant ozone causes myriad systemic metabolic and pulmonary effects attributed to sympathetic and hypothalamus-pituitary-adrenal (HPA) axis activation, which are exacerbated in metabolically-impaired models. We examined respiratory and systemic effects following exposure to a sensory irritant acrolein to elucidate the systemic and pulmonary consequences in healthy and diabetic rat models. Male Wistar and Goto Kakizaki (GK) rats, a non-obese type II diabetic Wistar-derived model, were exposed by inhalation to 0, 2, or 4 ppm acrolein, 4h/day for 1 or 2 days...
May 24, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28476050/influence-of-pilocarpine-and-timolol-on-human-meibomian-gland-epithelial-cells
#8
Yi Zhang, Wendy R Kam, Yang Liu, Xiaomin Chen, David A Sullivan
PURPOSE: Investigators have discovered that topical antiglaucoma drugs may induce meibomian gland dysfunction. This response may contribute to the dry eye disease commonly found in patients with glaucoma taking such medications. We hypothesize that drug action involves a direct effect on human meibomian gland epithelial cells (HMGECs). To test this hypothesis, we examined the influence of the antiglaucoma drugs, pilocarpine and timolol, on the morphology, survival, proliferation, and differentiation of HMGECs...
June 2017: Cornea
https://www.readbyqxmd.com/read/28473666/the-palmitoylation-of-the-n-terminal-extracellular-cys37-mediates-the-nuclear-translocation-of-vpac1-contributing-to-its-anti-apoptotic-activity
#9
Rongjie Yu, Hongyu Liu, Xinhe Peng, Yue Cui, Suqin Song, Like Wang, Huahua Zhang, An Hong, Tianhong Zhou
VPAC1 is class B G protein-coupled receptors (GPCR) shared by pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP). The first cysteine (Cys37) in the N-terminal extracellular domain of mature VPAC1 is a free Cys not involved in the formation of conserved intramolecular disulfide bonds. In order to investigate the biological role of this Cys37 in VPAC1, the wild-type VPAC1 and Cys37/Ala mutant (VPAC1-C37/A) were expressed stably as fusion proteins with enhanced yellow fluorescent protein (EYFP) respectively in Chinese hamster ovary (CHO) cells...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28470485/biomarkers-of-suicide-attempt-behavior-towards-a-biological-model-of-risk
#10
REVIEW
Katherin Sudol, J John Mann
PURPOSE OF REVIEW: The rising suicide rate in the USA will not be reversed without improved risk assessment and prevention practices. To date, the best method for clinicians to assess a patient's risk for suicide is screening for past suicide attempts in the patient and their family. However, neuroimaging, genomic, and biochemical studies have generated a body of findings that allow description of an initial heuristic biological model for suicidal behavior that may have predictive value...
June 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28457949/%C3%A3-ngstrom-size-exocytotic-fusion-pore-implications-for-pituitary-hormone-secretion
#11
REVIEW
Marko Kreft, Jernej Jorgačevski, Matjaž Stenovec, Robert Zorec
In the past, vesicle content release was thought to occur immediately and completely after triggering of exocytosis. However, vesicles may merge with the plasma membrane to form an Ångstrom diameter fusion pore that prevents the exit of secretions from the vesicle lumen. The advantage of such a narrow pore is to minimize the delay between the trigger and the release. Instead of stimulating a sequence of processes, leading to vesicle merger with the plasma membrane and a formation of a fusion pore, the stimulus only widens the pre-established fusion pore...
April 27, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28433506/heifers-express-g-protein-coupled-receptor-61-in-anterior-pituitary-gonadotrophs-in-stage-dependent-manner
#12
Kiran Pandey, Onalenna Kereilwe, Vitaliano Borromeo, Hiroya Kadokawa
Gonadotropin-releasing hormone receptors (GnRHRs) colocalize with insulin and glucocorticoid receptors in lipid rafts of the gonadotroph plasma membrane, where they facilitate downstream signaling. We recently found that orphan G-protein-coupled receptor (GPR)61 is expressed in the anterior pituitary (AP) of heifers, leading us to speculate that GPR61 colocalizes with GnRHR in the plasma membrane of gonadotroph and is expressed at specific times of the reproductive cycle. To test this hypothesis, we examined the coexpression of GnRHR, GPR61, and either luteinizing hormone (LH) β subunit or follicle-stimulating hormone (FSH) β subunit in AP tissue and cultured AP cells by immunofluorescence microscopy...
April 4, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28384517/biomarker-response-and-hypothalamus-pituitary-interrenal-axis-functioning-in-arctic-charr-from-bj%C3%A3-rn%C3%A3-ya-74%C3%A2-30-%C3%A2-n-norway-with-high-levels-of-organohalogenated-compounds
#13
Even H Jørgensen, Alec G Maule, Anita Evenset, Guttorm Christensen, Jenny Bytningsvik, Marianne Frantzen, Vladimir Nikiforov, Erin Faught, Mathilakath M Vijayan
The populations of Arctic charr (Salvelinus alpinus) residing in Lake Ellasjøen at Bjørnøya Island in the Norwegian Arctic (74° 30'N, 19° 00'E) possess substantially higher levels of organohalogenated compounds (strongly dominated by polychlorinated biphenyls, PCBs) than conspecifics residing in other, proximate lakes on the island. In the present study we sampled large (<400g), immature charr from Lake Ellasjøen (high PCB levels) and Lake Laksvatn (reference lake, low PCB levels) by hook and line for an immediate blood sampling, and blood and tissue sampling after a 1h confinement stressor...
June 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28379580/association-of-tsh-with-cardiovascular-disease-risk-in-overweight-and-obese-children-during-lifestyle-intervention
#14
Jesse M Rijks, Jogchum Plat, Elke Dorenbos, Bas Penders, Willem-Jan M Gerver, Anita C E Vreugdenhil
Context: Overweight and obese children have an increased risk to develop cardiovascular diseases (CVDs) in which thyroid-stimulating hormone (TSH) has been suggested as an intermediary factor. However, results of cross-sectional studies are inconclusive, and intervention studies investigating changes in TSH concentrations in association with changes in cardiovascular risk parameters in overweight and obese children are scarce. Objective: To gain insight in associations of circulating TSH concentrations and cardiovascular risk parameters in overweight and obese children...
June 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28356733/a-novel-selective-vpac2-agonist-peptide-conjugated-chitosan-modified-selenium-nanoparticles-with-enhanced-anti-type-2-diabetes-synergy-effects
#15
Shao-Jun Zhao, De-Hua Wang, Yan-Wei Li, Lei Han, Xing Xiao, Min Ma, David Chi-Cheong Wan, An Hong, Yi Ma
A novel neuroendocrine peptide, pituitary adenylate cyclase activating peptide (PACAP), was found to have an important role in carbohydrate or lipid metabolism and was susceptible to dipeptidyl peptidase IV degradation. It can not only mediate glucose-dependent insulin secretion and lower blood glucose by activating VPAC2 receptor, but also raise blood glucose by promoting glucagon production by VPAC1 receptor activation. Therefore, its therapeutic application is restricted by the exceedingly short-acting half-life and the stimulatory function for glycogenolysis...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28341876/consumption-of-green-tea-epigallocatechin-3-gallate-enhances-systemic-immune-response-antioxidative-capacity-and-hpa-axis-functions-in-aged-male-swiss-albino-mice
#16
Rohit Sharma, Anamika Sharma, Amita Kumari, Pankaj Markand Kulurkar, Rajneesh Raj, Ashu Gulati, Yogendra S Padwad
The present investigation assessed the potential of green tea phytochemical epigallocatechin-3-gallate (EGCG) in alleviating age-associated aberrations in immunity, hypothalamus-pituitary-adrenal (HPA) axis and redox homeostasis using 16 months old male Swiss albino mice. Four groups of animals (n = 6 per group) were supplemented with either aqueous EGCG at 25, 50 and 100 mg/kg/animal or vehicle control for 6 weeks. A concurrent analysis of CD4(+) and CD8(+) lymphocytes in splenocytes, differential leucocyte population, T cell differentiation markers in peripheral blood mononuclear cells (PBMCs), neutrophil functions, immunoglobulins profile in intestine, circulatory HPA axis hormonal levels as well as inflammatory and oxidative stress in the liver was performed...
June 2017: Biogerontology
https://www.readbyqxmd.com/read/28324017/a-novel-selective-bombesin-receptor-subtype-3-agonist-promotes-weight-loss-in-male-diet-induced-obese-rats-with-circadian-rhythm-change
#17
Yasunori Nio, Natsu Hotta, Minoru Maruyama, Kenichi Hamagami, Toshimi Nagi, Masaaki Funata, Junichi Sakamoto, Masanori Nakakariya, Nobuyuki Amano, Tomohiro Okawa, Yasuyoshi Arikawa, Shinobu Sasaki, Shoki Okuda, Shizuo Kasai, Yugo Habata, Yasutaka Nagisa
Bombesin receptor subtype 3 (BRS-3) is an orphan G-protein-coupled receptor. Based on the obese phenotype of male BRS-3-deficient mice, BRS-3 has been considered an attractive target for obesity treatment. Here, we developed a novel selective BRS-3 agonist (Compound-A) and evaluated its anti-obesity effects. Compound-A showed anorectic effects and enhanced energy expenditure in diet-induced obese (DIO)-F344 rats. Moreover, repeated oral administration of Compound-A for 7 days resulted in a significant body weight reduction in DIO-F344 rats...
March 16, 2017: Endocrinology
https://www.readbyqxmd.com/read/28319849/the-association-between-three-major-physiological-stress-systems-and-oxidative-dna-and-lipid-damage
#18
Catherine N Black, Mariska Bot, Dóra Révész, Peter G Scheffer, Brenda Penninx
BACKGROUND: Increased activity of the three major physiological stress systems (immune-inflammatory system, hypothalamic-pituitary-adrenal-axis [HPA-axis], and autonomic nervous system [ANS]) is part of the pathophysiology of various somatic and psychiatric diseases. Oxidative damage is a key mechanism in both ageing and disease. Elucidating the relationship between these stress systems and oxidative damage would contribute to the understanding of the role of physiological stress in disease...
June 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28261157/transcriptome-profile-of-rat-adrenal-evoked-by-gonadectomy-and-testosterone-or-estradiol-replacement
#19
Karol Jopek, Piotr Celichowski, Marta Szyszka, Marianna Tyczewska, Paulina Milecka, Ludwik K Malendowicz, Marcin Rucinski
Sex differences in adrenal cortex structure and function are well known in different species. In the rat, they are manifested as larger adrenal cortex and higher corticosterone secretion by females compared with males. These sex differences depend, among others, on functioning of the hypothalamic-pituitary-adrenal axis (HPA). In this aspect, it is widely accepted that testosterone exerts an inhibitory and estradiol stimulatory effect on the said axis. The molecular bases of these sex-related differences are poorly understood...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28239611/pleotropic-acute-and-chronic-effects-of-leptin-to-reverse-type-1-diabetes
#20
Rachel J Perry
Recent studies have demonstrated that leptin can prolong life chronically in rats with poorly-controlled type 1 diabetes (T1D). Multiple explanations have been proposed to explain leptin's chronic antihyperglycemic effect, including suppression of glucagon release and/or signaling, reductions in hyperphagia and ectopic lipid content, and improvements in insulin sensitivity; it is leptin's ability to reduce plasma glucose relies on all of these effects. In addition, leptin reverses hyperglycemia and diabetic ketoacidosis (DKA) acutely, within 6 hours of leptin infusion, by suppressing hypothalamic-pituitary-adrenal (HPA) axis activity in insulinopenic rats...
January 2017: Postdoc Journal
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