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Improving chronic disability

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https://www.readbyqxmd.com/read/29161722/the-impact-of-tumor-necrosis-factor-%C3%AE-and-interleukin-1%C3%AE-levels-and-polymorphisms-on-long-term-stroke-outcomes
#1
Ju-Wan Kim, Man-Seok Park, Joon-Tae Kim, Hee-Ju Kang, Kyung-Yeol Bae, Sung-Wan Kim, Myung-Geun Shin, Ki-Hyun Cho, Jae-Min Kim
BACKGROUND: The accuracy of predictions regarding disability that sets in after stroke could be improved by using blood biomarker measurements. This study aimed to investigate the roles of serum tumor necrosis factor alpha (TNF-α) and interleukin (IL)-1β concentrations and polymorphisms in stroke outcomes. METHODS: In total, 286 patients were evaluated at the time of admission and at 2 weeks after stroke, and 222 of these patients (78%) were followed up for 1 year to evaluate the consequences of stroke during both the acute and chronic stages...
November 21, 2017: European Neurology
https://www.readbyqxmd.com/read/29161622/on-denny-brown-s-spastic-dystonia-what-is-it-and-what-causes-it
#2
REVIEW
Jakob Lorentzen, Maud Pradines, Jean-Michel Gracies, Jens Bo Nielsen
In this review, we will work around two simple definitions of two different entities, which most often co-exist in patients with lesions to central motor pathways: Spasticity is "Enhanced excitability of velocity-dependent responses to phasic stretch at rest", which will not be the subject of this review, while Spastic dystonia is tonic, chronic, involuntary muscle contraction in the absence of any stretch or any voluntary command (Gracies, 2005). Spastic dystonia is a much less well understood entity that will be the subject this review...
November 4, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29160551/effects-of-pilates-and-yoga-in-patients-with-chronic-neck-pain-a-sonographic-study
#3
Naime Uluğ, Öznur Tunca Yılmaz, Murat Kara, Levent Özçakar
BACKGROUND: Various studies have shown the efficacy of conventional isometric, Pilates and yoga exercises. However, data on the effects and comparison of these specific exercises on the cervical muscle morphology are insufficient or lacking. OBJECTIVE: To investigate the effects of different exercise treatments on neck muscles in patients with chronic neck pain. DESIGN: A randomized study. METHODS: Fifty-six patients with chronic neck pain were randomized into 3 groups as follows: Pilates group (n = 20), yoga group (n = 18) and isometric group (n = 18)...
November 16, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29156985/isolated-lumbar-extension-resistance-training-improves-strength-pain-and-disability-but-not-spinal-height-or-shrinkage-creep-in-participants-with-chronic-low-back-pain
#4
James Steele, Stewart Bruce-Low, Dave Smith, David Jessop, Neil Osborne
OBJECTIVE: Loss of disc height is commonly associated with chronic low back pain (CLBP). Isolated lumbar extension (ILEX) exercise for the lumbar extensors is recommended to treat CLBP and is suggested such exercise might promote disc healing and regeneration. This study examined a 12-week ILEX intervention on indirect determination of disc height and shrinkage through seated stadiometry, strength, pain, and disability. DESIGN: A quasi-experimental wait-list controlled design was used...
February 1, 2017: Cartilage
https://www.readbyqxmd.com/read/29156166/allograft-bone-what-is-the-role-of-platelet-derived-growth-factor-in-hindfoot-and-ankle-fusions
#5
REVIEW
Ryan T Scott, Jeffrey E McAlister, Ryan B Rigby
Arthrodesis of the ankle or foot is a common procedure for chronic pain and disability. Nonunion remains a prevalent complication among arthrodesis procedures. Some patients present with an inherent risk of developing a nonunion. Allograft biologics have gained popularity in an effort to reduce complications such as nonunion. Various biologics bring unique properties while maintaining a singular purpose. Platelet-derived growth factor (PDGF) may be introduced into a fusion site to facilitate healthy bony consolidation...
January 2018: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/29154428/muscle-wasting-and-sarcopenia-in-heart-failure-and-beyond-update-2017
#6
REVIEW
Jochen Springer, Joshua-I Springer, Stefan D Anker
Sarcopenia (loss of muscle mass and muscle function) is a strong predictor of frailty, disability and mortality in older persons and may also occur in obese subjects. The prevalence of sarcopenia is increased in patients suffering from chronic heart failure. However, there are currently few therapy options. The main intervention is resistance exercise, either alone or in combination with nutritional support, which seems to enhance the beneficial effects of training. Also, testosterone has been shown to increased muscle power and function; however, a possible limitation is the side effects of testosterone...
November 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29150201/nations-within-a-nation-variations-in-epidemiological-transition-across-the-states-of-india-1990-2016-in-the-global-burden-of-disease-study
#7
(no author information available yet)
BACKGROUND: 18% of the world's population lives in India, and many states of India have populations similar to those of large countries. Action to effectively improve population health in India requires availability of reliable and comprehensive state-level estimates of disease burden and risk factors over time. Such comprehensive estimates have not been available so far for all major diseases and risk factors. Thus, we aimed to estimate the disease burden and risk factors in every state of India as part of the Global Burden of Disease (GBD) Study 2016...
November 13, 2017: Lancet
https://www.readbyqxmd.com/read/29143899/headache-in-resource-limited-settings
#8
REVIEW
Yohannes W Woldeamanuel
PURPOSE OF REVIEW: This review summarizes the unmet need of headache burden and management in resource-limited settings. It provides a general overview of the nuances and peculiarities of headache disorders in resource-limited settings. The review delivers perspectives and explanations for the emerging burden of both primary and secondary headache disorders. Important discussion on demographic and epidemiologic transition pertinent to low-resource settings is included. A critical analysis of headache disorders is made within the context of growing burden non-communicable disorders in low-resource countries...
November 16, 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29141662/safety-and-tolerability-of-intradiscal-implantation-of-combined-autologous-adipose-derived-mesenchymal-stem-cells-and-hyaluronic-acid-in-patients-with-chronic-discogenic-low-back-pain-1-year-follow-up-of-a-phase-i-study
#9
Hemant Kumar, Doo-Hoe Ha, Eun-Jong Lee, Jun Hee Park, Jeong Hyun Shim, Tae-Keun Ahn, Kyoung-Tae Kim, Alexander E Ropper, Seil Sohn, Chung-Hun Kim, Devang Kashyap Thakor, Soo-Hong Lee, In-Bo Han
BACKGROUND: Adipose tissue-derived mesenchymal stem cells (AT-MSCs) offer potential as a therapeutic option for chronic discogenic low back pain (LBP) because of their immunomodulatory functions and capacity for cartilage differentiation. The goal of this study was to assess the safety and tolerability of a single intradiscal implantation of combined AT-MSCs and hyaluronic acid (HA) derivative in patients with chronic discogenic LBP. METHODS: We performed a single-arm phase I clinical trial with a 12-month follow-up and enrolled 10 eligible chronic LBP patients...
November 15, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29140901/-state-of-the-art-techniques-in-treating-peripheral-nerve-injury
#10
Carrie A Kubiak, Theodore A Kung, David L Brown, Paul S Cederna, Stephen W P Kemp
BACKGROUND -: Peripheral nerve injuries remain a major clinical concern as they often lead to chronic disability and significant health care expenditures. Despite advancements in microsurgical techniques to enhance nerve repair, biologic approaches are needed to augment nerve regeneration and improve functional outcomes after injury. METHODS -: Presented herein is a review of the current literature on state of the art techniques to enhance functional recovery for patients with nerve injury...
November 11, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29137878/integration-of-medicare-and-medicaid-for-dually-eligible-beneficiaries-a-focus-group-study-examining-beneficiaries-early-experiences-in-california-s-dual-financial-alignment-demonstration
#11
Carrie L Graham, Holly C Stewart, Elaine Kurtovich, Pi-Ju Liu
BACKGROUND: In 2014 California implemented a federal dual alignment demonstration that used a capitated managed care health plans called Cal MediConnect (CMC) to integrate medical care and long term services and supports (LTSS) for beneficiaries with both Medicare and Medicaid. These beneficiaries often have complex care needs, including multiple chronic conditions and disabilities. By 2016, 120,000 eligible beneficiaries were enrolled in the program. OBJECTIVES: Focus groups with enrolled beneficiaries were conducted to gather rich data about their early experiences with quality of care, access to care, and coordination of care in CMC plans and to identify recommendations for program improvement...
July 21, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/29134513/current-concepts-and-unmet-needs-in-psoriatic-arthritis
#12
Farrouq Mahmood, Laura C Coates, Philip S Helliwell
Psoriatic arthritis is a chronic inflammatory arthritis that is part of the spondyloarthropathy group of rheumatic diseases and has associated co-morbidities. It can present with various clinical manifestations making diagnosis and treatment challenging, resulting in significant disability and reduced quality of life for patients. Whilst there have been advances in understanding the pathogenic mechanisms of the disease which have resulted in targeted therapies, there is still the need for further studies as some patients fail or are intolerant of current therapies...
November 13, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29131328/headache-education-active-waiting-directive-a-program-to-enhance-well-being-during-long-referral-wait-times
#13
Ana Marissa Lagman-Bartolome, Valerie Lawler, Christine Lay
OBJECTIVE: The aim of this initiative was to evaluate the clinical impact, patient acceptability, and sustainability of implementing a newly developed evidence-guided migraine education program in an academic headache center. BACKGROUND: Headache is the fifth most common reason for emergency department (ED) visits and accounts for more than 10 million physician visits annually. Successful management of headaches presents a challenge to both primary care providers and neurologists...
November 12, 2017: Headache
https://www.readbyqxmd.com/read/29127611/tacrolimus-as-an-adjunct-to-autologous-minced-muscle-grafts-for-the-repair-of-a-volumetric-muscle-loss-injury
#14
Benjamin T Corona, Jessica C Rivera, Joseph C Wenke, Sarah M Greising
BACKGROUND: Volumetric muscle loss (VML) following extremity orthopaedic trauma or surgery results in chronic functional deficits and disability. A current translational approach to address the devastating functional limitations due to VML injury is the use of an autologous minced muscle graft (~1 mm(3) pieces of muscle tissue) replacement into the injured defect area, although limitations related to donor site morbidity are still unaddressed. This study was designed to explore adjunct pharmacological immunomodulation to enhance graft efficacy and promote muscle function following VML injury, and thereby reduce the amount of donor tissue required...
November 10, 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29127076/tailored-web-based-interventions-for-pain-systematic-review-and-meta-analysis
#15
Geraldine Martorella, Madalina Boitor, Melanie Berube, Suzanne Fredericks, Sylvie Le May, Céline Gélinas
BACKGROUND: Efforts have multiplied in the past decade to underline the importance of pain management. For both acute and chronic pain management, various barriers generate considerable treatment accessibility issues, thereby providing an opportunity for alternative intervention formats to be implemented. Several systematic reviews on Web-based interventions with a large emphasis on chronic pain and cognitive behavioral therapy have been recently conducted to explore the influence of these interventions on pain management However, to our knowledge, the specific contribution of tailored Web-based interventions for pain management has not been described and their effect on pain has not been evaluated...
November 10, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29126981/therapeutic-effect-of-adjunctive-n-acetyl-cysteine-nac-on-symptoms-of-chronic-schizophrenia-a-double-blind-randomized-clinical-trial
#16
Zahra Sepehrmanesh, Mahsa Heidary, Negar Akasheh, Hossein Akbari, Mahshid Heidary
BACKGROUND: Schizophrenia is one of the most disabling psychiatric syndromes with the prevalence of 1% in the general population. Despite availability of various antipsychotics, negative symptoms and cognitive impairment are difficult to treat. In addition antipsychotic monotherapy is not effective in most of these patients. Current evidence indicates the roles of glutamatergic system in this disorder. N-acetyl cysteine (NAC) also increases extracellular glutamate. This study was conducted to evaluate the clinical effects of oral NAC as an add-on to maintenance medication for the treatment of chronic schizophrenia...
November 7, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29126081/multiple-chronic-condition-profiles-and-survival-among-oldest-old-male-patients-with-hip-fracture
#17
Jinmyoung Cho, Eileen M Stock, I-Chia Liao, John E Zeber, Brian K Ahmedani, Rashmita Basu, Charlene C Quinn, Laurel A Copeland
To improve understanding of survival among very elderly male patients with surgically repaired hip fractures, this study applied classification techniques to multiple chronic conditions (MCC) then modeled survival by latent class. Veterans Health Administration (VHA)'s electronic medical records on male inpatients age 85-100 years (n=896) with hip fracture diagnosis and repair were used. MCC defined by Charlson and Elixhauser disorders, medications, demographic covariates, and 5 years follow-up survival were included...
October 28, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29122462/yoga-may-be-noninferior-to-physical-therapy-for-disability-and-pain-at-12-weeks-and-both-might-improve-function-more-than-education-in-low-resource-adults-with-chronic-nonspecific-low-back-pain
#18
Daniel A Ostrovsky
No abstract text is available yet for this article.
October 12, 2017: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/29122255/the-medium-term-effects-of-diadynamic-currents-in-chronic-low-back-pain-tens-versus-diadynamic-currents-a-randomised-follow-up-study
#19
Selcuk Sayilir, Mustafa Turgut Yildizgoren
OBJECTIVE: The aims of the study were to evaluate the medium-term effects of diadynamic (DD) currents on relieving symptoms/improving physical functionality in patients with chronic low back pain (LBP) and to compare the efficacy of DD versus TENS. METHODS: The patients were divided into two groups as the TENS group (n = 26) and the DD group (n = 29). Additional treatment of hot pack + therapeutic ultrasound was applied to all patients. The therapy programs were administered as a total of 10 sessions over a period of 2 weeks...
November 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29119827/a-two-week-inpatient-programme-with-a-booster-improved-long-term-management-of-severe-chronic-paediatric-pain
#20
János Major, Zsófia K Varga, Andrea Gyimesi-Szikszai, Szilvia Ádám
In the context of limited healthcare resources and increasing demands for more cost-effective healthcare solutions, this study assessed the short- and long-term clinical outcomes and resource utilization of a two-week inpatient, interdisciplinary, pain treatment (IIPT) including individual and group cognitive behavioural, occupational, physical and recreational therapy, education and family intervention and a booster in the chronic paediatric pain setting. Using a longitudinal design with a two-year follow-up, two-week IIPT resulted in sustainable improvements in mean and maximum pain intensity, physical functioning and internalization and reductions in the mean number of medical visits, school absence and frequency of pain medication at year 2 following IIPT...
June 2017: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
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