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Alendronate cinacalcet

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https://www.readbyqxmd.com/read/25162668/medical-management-of-primary-hyperparathyroidism-proceedings-of-the-fourth-international-workshop-on-the-management-of-asymptomatic-primary-hyperparathyroidism
#1
Claudio Marcocci, Jens Bollerslev, Aliya Aziz Khan, Dolores Marie Shoback
OBJECTIVE: Asymptomatic primary hyperparathyroidism (PHPT) is a common clinical problem. The only available definitive therapy is parathyroidectomy, which is appropriate to consider in all patients. The purpose of this report is to provide an update on calcium and vitamin D supplementation and medical management for those patients with PHPT who cannot or do not want to undergo surgery. METHODS: Questions were developed by the International Task Force on PHPT. A comprehensive literature search was undertaken, and relevant articles published between 2008 and 2013 were reviewed in detail...
October 2014: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/23024712/bone-disease-in-primary-hyperparathyrodism
#2
Claudio Marcocci, Luisella Cianferotti, Filomena Cetani
Nowadays, primary hyperparathyroidism (PHPT) is mostly a mild disease. Overt skeletal manifestations are rare but decreased bone mineral density (BMD) can still be demonstrated. Even in mild cases, excess parathyroid hormone (PTH) increases bone turnover leading to bone loss particularly at cortical sites. Conversely, a relative preservation of cancellous bone has been shown by histomorphometric analyses and advanced imaging techniques. An increased fracture rate has been demonstrated in untreated patients with PHPT at peripheral sites and in the spine...
October 2012: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/21445714/cinacalcet-hydrochloride-in-combination-with-alendronate-normalizes-hypercalcemia-and-improves-bone-mineral-density-in-patients-with-primary-hyperparathyroidism
#3
COMPARATIVE STUDY
A Faggiano, C Di Somma, V Ramundo, R Severino, L Vuolo, A Coppola, F Panico, S Savastano, G Lombardi, A Colao, M Gasperi
Cinacalcet is effective in controlling the biochemical abnormalities in patients with primary hyperparathyroidism (PHPT) but it seems to be less effective on bone mineral density (BMD). In the same patients, bisphosphonates are reported to be effective on bone resorption but less effective on calcium and PTH excess. In this study, the efficacy of cinacalcet in combination with alendronate has been retrospectively evaluated in patients with PHPT. Twenty-three patients with PHPT who had not been operated were retrospectively investigated...
June 2011: Endocrine
https://www.readbyqxmd.com/read/16801985/gateways-to-clinical-trials
#4
M BayƩs, X Rabasseda, J R Prous
Gateways to Clinical Trials are a guide to the most recent clinical trials in current literature and congresses. The data in the following tables have been retrieved from the Clinical Trials Knowledge Area of Prous Science Integrity, the drug discovery and development portal, http://integrity.prous.com/. This issue focuses on the following selection of drugs: Adalimumab, adenosine triphosphate, alemtuzumab, alendronate sodium/cholecalciferol, aliskiren fumarate, AMGN-0007, aminolevulinic acid methyl ester, anakinra, anidulafungin, aripiprazole, atomoxetine hydrochloride; Bevacizumab, bosentan; Calcipotriol/beta methasone dipropionate, caldaret hydrate, caspofungin acetate, cetuximab, cinacalcet hydrochloride, clopidogrel, cocaine-BSA conjugate, conivaptan hydrochloride, Cypher; Darbepoetin alfa, delmitide, desloratadine, desmoteplase, desoxyepothilone B, disufenton sodium, DU-176b, duloxetine hydrochloride, dutasteride; EBV-specific CTLs, ecogramostim, edodekin alfa, efalizumab, eletriptan, emtricitabine, entecavir, erlotinib hydrochloride, ertapenem sodium, escitalopram oxalate, etoricoxib, everolimus, ezetimibe; Fanapanel, fondaparinux sodium; Gefitinib, GTI-2040, GW-501516; Her2 E75-peptide vaccine, human insulin; Ibogaine, icatibant acetate, Id-KLH vaccine, imatinib mesylate, immune globulin subcutaneous [human], indacaterol, inolimomab, ipilimumab, i...
May 2006: Methods and Findings in Experimental and Clinical Pharmacology
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