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JOURNAL ARTICLE
Sakcham Bairoliya, Apoorva Goel, Manisha Mukherjee, Jonas Koh Zhi Xiang, Bin Cao
Monochloramine (MCA) is a widely used secondary disinfectant to suppress microbial growth in drinking water distribution systems. In monochloraminated drinking water, a significant amount of extracellular DNA (eDNA) has been reported, which has many implications ranging from obscuring DNA-based drinking water microbiome analyses to posing potential health concerns. To address this, it is imperative for us to know the origin of the eDNA in drinking water. Using Pseudomonas aeruginosa as a model organism, we report for the first time that MCA induces the release of nucleic acids from both biofilms and planktonic cells...
October 10, 2022: Environmental Science & Technology
#22
JOURNAL ARTICLE
Ashwarya Kapoor, Rajiv Sindwani, Manisha Goel, Amit Shankar
This research aims to explore adoption intention towards mobile wallet (m-wallet) amid COVID-19 outbreak using mediated-moderation framework. This study, in its uniqueness, utilises the stimulus-organism-response (S-O-R) theory as its theoretical base. The study investigated the effect of relative advantage, ease of effort, favourable infrastructure conditions, security considerations, and touch-free transactions on m-wallet adoption. The model includes perceived values as a mediator and perceived critical mass (PCM), promotional benefits (PBs) and users' demographics as moderators for deeper understanding of the phenomenon...
October 2022: Computers & Industrial Engineering
#23
JOURNAL ARTICLE
Maryam Alsharqi, Vijay A Ismavel, Linda Arnold, Saswati S Choudhury, Carolin Solomi V, Sereesha Rao, Tina Nath, Anjali Rani, Isha Goel, Swapna D Kakoty, Pranabika Mahanta, Indrani Roy, Rupanjali Deka, Charles Opondo, Colin Baigent, Paul Leeson, Manisha Nair
BACKGROUND: Cardiac complications are a leading cause of maternal death. Cardiac imaging with echocardiography is important for prompt diagnosis, but it is not available in many low-resource settings. The aim of our study was to determine whether focused cardiac ultrasound performed by trained obstetricians and interpreted remotely by experts can identify cardiac abnormalities in pregnant women in low-resource settings. METHODS: Cross-sectional study of 301 pregnant and postpartum women recruited from ten hospitals across three States in India...
August 4, 2022: Journal of the American Society of Echocardiography
#24
Sanjoli Chugh, Priyanka Kumari, Shriya Goel, Manisha Biswal, Inderpaul Singh Sehgal, Aravind Sekar
Rickettsial diseases (RD) are a group of endotheliotropic infectious diseases caused by different species of genera Rickettsia . RD are not an uncommon disease and may be misdiagnosed during the evaluation of acute febrile illness due to a lack of reliable serological marker and diagnostic culture methods. Clinical manifestation of RD varies from febrile illness with rashes and myalgia to fatal complications such as shock and respiratory failure. We describe a case of a young male who presented initially with acute febrile illness, followed by shock and respiratory failure, and unfortunately succumbed to death...
2022: Autopsy & Case Reports
#25
JOURNAL ARTICLE
Amit Gupta, Priyanka Naranje, Zainab Vora, Raju Sharma, Manisha Jana, Ashu Seith Bhalla, Pallavi Sinha, Rohan Malik, Prabudh Goel, Anjan Dhua, Devasenathipathy Kandasamy
OBJECTIVE: To assess the effectiveness of intranodal lymphangiography using ethiodised oil (Lipiodol; Guerbet Japan, Tokyo, Japan) for the treatment of refractory cases of chylothorax and chylous ascites in the paediatric population. METHODS: Between 2016 and 2020, eight children having chyle leak resistant to conservative management underwent intranodal lymphangiography using lipiodol injection. After ethical approval by the Institutional Review Board, these patients' data were retrospectively analysed...
September 1, 2022: British Journal of Radiology
#26
JOURNAL ARTICLE
Tarun Bhatnagar, Sirshendu Chaudhuri, Manickam Ponnaiah, Pragya D Yadav, R Sabarinathan, Rima R Sahay, Faheem Ahmed, S Aswathy, Pankaj Bhardwaj, Anil Bilimale, M Santhosh Kumar, M Logaraj, Uday Narlawar, C Palanivel, Prakash Patel, Sanjay K Rai, Vartika Saxena, Arvind Singh, Jeromie Wv Thangaraj, Ashwini Agarwal, Yasir Alvi, Amoghashree, P Ashok, Dinesh Babu, Yogesh Bahurupi, Sangita Bhalavi, Priyamadhaba Behera, Priyanka Pandit Biswas, Jaykaran Charan, Nishant Kumar Chauhan, K B Chetak, Lalit Dar, Ayan Das, R Deepashree, Minakshi Dhar, Rahul Dhodapkar, T S Dipu, Mridu Dudeja, Manisha Dudhmal, Ravisekhar Gadepalli, Mahendra Kumar Garg, A V Gayathri, Akhil Dhanesh Goel, H Basavana Gowdappa, Randeep Guleria, Manoj Kumar Gupta, Farzana Islam, Mannu Jain, Vineet Jain, M Lanord Stanley Jawahar, Rajendra Joshi, Shashi Kant, Sitanshu Sekhar Kar, Deepjyoti Kalita, Meenakshi Khapre, Satyendra Khichar, Sarika Prabhakar Kombade, Sunil Kohli, Abhinendra Kumar, Anil Kumar, Deepak Kumar, Kiran G Kulirankal, K V Leela, Triparna Majumdar, Baijayantimala Mishra, Puneet Misra, Sanjeev Misra, Prasanta Raghab Mohapatra, M Narayana Murthy, Dimpal A Nyayanit, Manish Patel, Monika Pathania, Savita Patil, Binod Kumar Patro, Ramniwas, Pragati Rathod, Naimesh Shah, Anita Shete, Deepak Shukla, M Shwethashree, Smita Sinha, Ashish Surana, Anjan Trikha, A Tejashree, Mahalingam Venkateshan, G Vijaykrishnan, Sarita Wadhava, Naveet Wig, Nivedita Gupta, Priya Abraham, Manoj V Murhekar
BACKGROUND: India introduced BBV152/Covaxin and AZD1222/Covishield vaccines from January 2021. We estimated effectiveness of these vaccines against severe Coronavirus disease 2019 (COVID-19) among individuals aged ≥45 years. METHODS: We did a multi-centric, hospital-based, case-control study between May and July 2021. Cases were severe COVID-19 patients and controls were COVID-19 negative individuals from 11 hospitals. Vaccine effectiveness (VE) was estimated for full (2 doses ≥14days) and partial (1 dose ≥21 days) vaccination; duration between two vaccine doses and against the Delta variant...
July 14, 2022: International Journal of Infectious Diseases: IJID
#27
JOURNAL ARTICLE
Sandeep Agarwala, Vishesh Jain, Anjan Dhua, Madur Srinivas, Prabudh Goel, Sameer Bakhshi, Venkateswaran K Iyer, Rajni Yadav, Manisha Jana, Priyanka Naranje, Veereshwar Bhatnagar
Background: Recent SIOPEL studies have shown cisplatin monotherapy to be equally effective in management of Standard risk Hepatoblastoma (SRHB)as compared to PLADO. Aims and Objectives: To study the chemotherapy, response and outcomes in children with SRHB. Material and Methods: A retrospective study was conducted and all children with SRHB who presented to us from June 2007 to December 2017 were included. All patients with standard risk hepatoblastoma who had received at least 2 cycles of chemotherapy were included...
May 2022: Journal of Indian Association of Pediatric Surgeons
#28
JOURNAL ARTICLE
Aparajita Lahree, Sara de Jesus Santos Baptista, Sofia Marques, Veronika Perschin, Vanessa Zuzarte-Luís, Manisha Goel, Hadi Hasan Choudhary, Satish Mishra, Christian Stigloher, Marino Zerial, Varadharajan Sundaramurthy, Maria M Mota
Intracellular pathogens manipulate host cells to survive and thrive. Cellular sensing and signaling pathways are among the key host machineries deregulated to favor infection. In this study, we show that liver-stage Plasmodium parasites compete with the host to sequester a host endosomal-adaptor protein (APPL1) known to regulate signaling in response to endocytosis. The enrichment of APPL1 at the parasitophorous vacuole membrane (PVM) involves an atypical Plasmodium Rab5 isoform (Rab5b). Depletion of host APPL1 alters neither the infection nor parasite development; however, upon overexpression of a GTPase-deficient host Rab5 mutant (hRab5_Q79L), the parasites are smaller and their PVM is stripped of APPL1...
May 31, 2022: Cell Reports
#29
JOURNAL ARTICLE
Sambit Sagar, Geetanjali Arora, Nishikant Damle, Rajni Sharma, Vandana Jain, Manisha Jana, Madhavi Tripathi, Chandrasekhar Bal, Prabudh Goel
AIM: Persistent hyperinsulinemic hypoglycemia is a rare but life-threatening disease of infancy and childhood. 18F-DOPA PET/CT has been shown to be a useful modality in the localization of focal pancreatic lesions in these patients. We aimed to assess the role of 18F-DOPA PET/CT in such patients at our institution. MATERIALS AND METHODS: In this prospective study, 18F-DOPA PET/CT scans and clinical details of 20 children with clinical diagnosis of hyperinsulinemic hypoglycemia were reviewed...
April 1, 2022: Nuclear Medicine Communications
#30
JOURNAL ARTICLE
Vineeta Kaushik, Anchal, Manisha Goel
The Archaea constitute separate domain of life and show resemblance with bacteria in their metabolic pathways while showing similarity with eukaryotes at the level of molecular processes such as cell division, DNA replication, protein synthesis, and proteostasis. However, the molecular machinery of archaea can be considered a simpler version of that found in eukaryotes because of the absence of multiple paralogs for any given molecular factor. Therefore, archaeal systems can possibly be used as a model system for understanding the eukaryotic protein folding machinery and thereby may help to address the molecular mechanism of various protein (mis)foldings and diseases...
January 11, 2022: ACS Omega
#31
JOURNAL ARTICLE
Anchal, Vineeta Kaushik, Manisha Goel
Cis-trans isomerization of the peptide bond prior to proline is an intrinsically slow process but plays an essential role in protein folding. In vivo cis-trans isomerization reaction is catalyzed by Peptidyl-prolyl isomerase (PPIases), a category of proteins widely distributed among all the three domains of life. The present study is majorly focused on the distribution of different types of PPIases in the archaeal domain. All the three hitherto known families of PPIases (namely FKBP, Cyclophilin and parvulin) were studied to identify the evolutionary conservation across the phylum archaea...
2021: Frontiers in Microbiology
#32
JOURNAL ARTICLE
Neelja Singhal, Anjali Garg, Nirpendra Singh, Pallavi Gulati, Manish Kumar, Manisha Goel
Secretory proteins are important for microbial adaptation and survival in a particular environment. Till date, experimental secretomes have been reported for a few archaea. In this study, we have identified the experimental secretome of Picrophilous torridus and evaluated the efficacy of various signal peptide predictors (SPPs) in identifying signal peptides (SPs) in its experimental secretome. Liquid chromatography mass spectrometric (LC MS) analysis was performed for three independent P. torridus secretome samples and only those proteins which were common in the three experiments were selected for further analysis...
2021: PloS One
#33
REVIEW
Shashank Shekhar, Shuchita Goyal, Manu Goel, Charu Sharma, Manisha Jhirwal
BACKGROUND: Laparoscopic repair of female pelvic organ prolapse is a technically challenging surgery, especially for the beginners. METHODS: We performed a follow-up study of women who underwent laparoscopic sacrocolpopexy or sacrohysteropexy (LSCP/LSHP) for pelvic organ prolapse between January 2015 and October 2019. We analysed anatomical and subjective success rates, peri-operative complications and medium-term complications. RESULTS: Twenty women underwent LSCP/LSHP with average follow-up of 16 months...
February 2021: Journal of Obstetrics and Gynaecology of India
#34
JOURNAL ARTICLE
Usha Dutta, Anurag Sachan, Madhumita Premkumar, Tulika Gupta, Swapnajeet Sahoo, Sandeep Grover, Sugandhi Sharma, P V M Lakshmi, Shweta Talati, Manisha Biswal, Vikas Suri, Mini P Singh, Babita Ghai, Rajesh Chhabra, Bhavneet Bharti, Jayanta Samanta, Pankaj Arora, Ritin Mohindra, Sunita Malhotra, Gurmeet Singh, Rashmi Ranjan Guru, Navin Pandey, Vipin Koushal, Ashok Kumar, Ranjitpal Singh Bhogal, Arun K Aggarwal, Kapil Goel, Pankaj Malhotra, Narayana Yaddanapudi, Pranay Mahajan, J S Thakur, Rakesh Sehgal, Arnab Ghosh, Inderpaul Singh Sehgal, Ritesh Agarwal, Muralidharan Jayashree, Ashish Bhalla, Sanjay Jain, Rakesh Kochhar, Arunaloke Chakrabarti, Goverdhan Dutt Puri, Jagat Ram
OBJECTIVES: Healthcare personnel (HCP) are at an increased risk of acquiring COVID-19 infection especially in resource-restricted healthcare settings, and return to homes unfit for self-isolation, making them apprehensive about COVID-19 duty and transmission risk to their families. We aimed at implementing a novel multidimensional HCP-centric evidence-based, dynamic policy with the objectives to reduce risk of HCP infection, ensure welfare and safety of the HCP and to improve willingness to accept and return to duty...
February 22, 2021: BMJ Open
#35
JOURNAL ARTICLE
Archana Sharma, Shobha Kumari, Manisha Goel
CsaA is known to function as a protein secretion chaperone in bacteria. Homologs of CsaA are also found in archaea while they are absent in eukaryotes. This paper presents the biophysical, biochemical analysis and crystallographic structure determination of CsaA from a thermoacidophilic archaeon Picrophilus torridus (PtCsaA). The PtCsaA appears to prevent the aggregation of heat denatured Bovine Carbonic Anhydrase II (BCAII). Differential denaturation of PtCsaA by guanidine hydrochloride (Gdn-HCl) and urea indicates the stabilization of the protein via salt bridges...
May 2021: Biochimica et Biophysica Acta. Proteins and Proteomics
#36
JOURNAL ARTICLE
Kuldeep Sachdeva, Manisha Goel, Malvika Sudhakar, Mansi Mehta, Rajmani Raju, Karthik Raman, Amit Singh, Varadharajan Sundaramurthy
Intracellular pathogens commonly manipulate the host lysosomal system for their survival. However, whether this pathogen-induced alteration affects the organization and functioning of the lysosomal system itself is not known. Here, using in vitro and in vivo infections and quantitative image analysis, we show that the lysosomal content and activity are globally elevated in Mycobacterium tuberculosis (Mtb)-infected macrophages. We observed that this enhanced lysosomal state is sustained over time and defines an adaptive homeostasis in the infected macrophage...
July 3, 2020: Journal of Biological Chemistry
#37
JOURNAL ARTICLE
Ruchira Nandan, Manisha Jana, Devendra Kumar Yadav, Prabudh Goel
A 126-day female child presented with jaundice since day 7 of life. She was icteric and had hepatosplenomegaly. Radiological investigations revealed three extrahepatic and multiple intrahepatic biliary cysts, absent gall bladder and portal vein. These findings were confirmed on laparotomy. To the best of our knowledge, this is the first report of cystic biliary atresia associated with congenital absence of portal vein.
January 18, 2021: BMJ Case Reports
#38
JOURNAL ARTICLE
Manojkumar R Shukla, Sukanya Patra, Mahip Verma, Gayathri Sadasivam, Nirmal Jana, Sachin J Mahangare, Prashant Vidhate, Dipak Lagad, Anand Tarage, Murthy Cheemala, Chaitanya Kulkarni, Shankar Bhagwat, Vinod D Chaudhari, Majid Sayyed, Vipul Pachpute, Ramesh Phadtare, Gopal Gole, Samiron Phukan, Brahmam Sunkara, Charudatt Samant, Manisha Shingare, Aditya Naik, Sneha Trivedi, Ajit Kumar Marisetti, Madhusudhan Reddy, Milind Gholve, Nilesh Mahajan, Sudeep Sabde, Vinod Patil, Dipak Modi, Maneesh Mehta, Prashant Nigade, Kaustubh Tamane, Swati Tota, Hemant Goyal, Harish Volam, Shashikant Pawar, Prajakta Ahirrao, Lal Dinchhana, Sadanand Mallurwar, Atul Akarte, Anand Bokare, Rupesh Kanhere, Neetinkumar Reddy, Sarita Koul, Manoj Dandekar, Minakshi Singh, Peter R Bernstein, Lakshmi Narasimham, Mandar Bhonde, Jayasagar Gundu, Rajan Goel, Sanjeev Kulkarni, Sharad Sharma, Rajender Kumar Kamboj, Venkata P Palle
PI3Kδ inhibitors have been approved for B-cell malignancies like CLL, small lymphocytic lymphoma, and so forth. However, currently available PI3Kδ inhibitors are nonoptimal, showing weakness against at least one of the several important properties: potency, isoform selectivity, and/or pharmacokinetic profile. To come up with a PI3Kδ inhibitor that overcomes all these deficiencies, a pharmacophoric expansion strategy was employed. Herein, we describe a systematic transformation of a "three-blade propeller" shaped lead, 2,3-disubstituted quinolizinone 11 , through a 1,2-disubstituted quinolizinone 20 to a novel "four-blade propeller" shaped 1,2,3-trisubstituted quinolizinone 34 ...
December 10, 2020: Journal of Medicinal Chemistry
#39
JOURNAL ARTICLE
Identification of Binding Partners of CsaA - An Archaeal Chaperonic Protein of Picrophilus torridus.
Neelja Singhal, Archana Sharma, Manisha Aswal, Nirpendra Singh, Manish Kumar, Manisha Goel
BACKGROUND: CsaA is among the few chaperones which are present in both bacteria and archaea, but absent in eukaryotes. There are no reports on interactome analysis of CsaA from archaea, till date. Identification of binding partners of CsaA might be helpful in understanding CsaA-associated processes in Picrophilus torridus an extreme thermoacidophilic euryarchaeon. OBJECTIVES: The present study was conducted to identify the binding partners of CsaA of P. torridus (PtCsaA)...
2021: Protein and Peptide Letters
#40
JOURNAL ARTICLE
Manisha Goel, Girish Venkataraman
No abstract text is available yet for this article.
November 5, 2020: Blood
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