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JOURNAL ARTICLE
Poonam Sherwani, Devasenathipathy Kandasamy, Raju Sharma, Prabudh Goel, Manisha Jana, Nellai Krishnan
UNLABELLED: The trajectory from the clinical identification of a benign liver mass to establishing a precise diagnosis is perplexing and arduous. Related contributory factors are that such lesions are encountered infrequently and that there is a nonavailability of dedicated paediatric radiologists in the developing world. The objective of this study was to review the spectrum of benign liver lesions in children and their typical imaging features. Cross-sectional imaging of all paediatric patients (< 18 years) with liver lesions (single and multiple) performed in the institute from 01 January 2018 to 01 January 2019 as well as those acquired at outside institutions and referred to the institute for management was included...
2024: SA journal of radiology
#2
JOURNAL ARTICLE
Snigdha Singh, Tanya Goel, Aarushi Singh, Heerak Chugh, Nayanika Chakraborty, Indrajit Roy, Manisha Tiwari, Ramesh Chandra
Novel magnetic and metallic nanoparticles garner much attention of researchers due to their biological, chemical and catalytic properties in many chemical reactions. In this study, we have successfully prepared a core-shell Fe3 O4 @SiO2 @PDA nanocomposite wrapped with Ag using a simple synthesis method, characterised and tested on small cell lung cancer and antibacterial strains. Incorporating Ag in Fe3 O4 @SiO2 @PDA provides promising advantages in biomedical applications. The magnetic Fe3 O4 nanoparticles were coated with SiO2 to obtain negatively charged surface which is then coated with polydopamine (PDA)...
December 2024: Artificial Cells, Nanomedicine, and Biotechnology
#3
JOURNAL ARTICLE
Shashank Shekhar, Pratibha Singh, Jeewan R Vishnoi, Shuchita Goel, Puneet Pareek, Charu Sharma, Manu Goyal, Garima Yadav, Manisha Jhirwal, Sweta Soni, Sanjeev Misra
BACKGROUND: In advanced-stage epithelial ovarian cancer (EOC) standard of care is upfront debulking surgery (UDS) followed by adjuvant chemotherapy. Interval debulking surgery after neoadjuvant chemotherapy(NACT-IDS) is a reasonable alternative. METHODS: This study was a retrospective review of patients of Stage III/IV EOC treated either by UDS or NACT-IDS between January 2016 and December 2018 to report the comparison of progression-free survival(PFS) and overall survival(OS) of patients with advanced-stage EOC treated with either UDS or NACT-IDS...
August 7, 2023: Indian Journal of Cancer
#4
Jasleen Kaur, Nalin Sharma, Rimjhim Kanaujia, Kamlesh Bisht, Shriya Goel, Manisha Biswal, Navneet Sharma
Scrub typhus is a zoonotic disease caused by Orientia tsutsugamushi. Although the presence of eschar is considered pathognomic, diagnosis of scrub typhus is challenging due to overlapping presentation. The diagnosis is based on the serological and molecular assay. Here, we describe a case of a young male patient who was diagnosed with scrub typhus and developed complications in the course of the disease. We also performed molecular characterization of the strain which revealed a close relatedness to Karp-like Linh...
2023: Indian Journal of Medical Microbiology
#5
JOURNAL ARTICLE
Chetkar Chandra Keshavam, Saba Naz, Aanchal Gupta, Priyadarshini Sanyal, Manisha Kochar, Aakriti Gangwal, Nitika Sangwan, Nishant Kumar, Ekta Tyagi, Simran Goel, Nitesh Kumar Singh, Divya Tej Sowpati, Garima Khare, Munia Ganguli, Dominique Raze, Camille Locht, Sharmila Basu-Modak, Meetu Gupta, Vinay Kumar Nandicoori, Yogendra Singh
Nucleoid-associated proteins (NAPs) regulate multiple cellular processes such as gene expression, virulence, and dormancy throughout bacterial species. NAPs help in the survival and adaptation of Mycobacterium tuberculosis (Mtb) within the host. Fourteen NAPs have been identified in Escherichia coli (E. coli); however, only seven NAPs are documented in Mtb. Given its complex lifestyle, it is reasonable to assume that Mtb would encode for more NAPs. Using bioinformatics tools and biochemical experiments, we have identified the heparin-binding haemagglutinin (HbhA) protein of Mtb as a novel sequence-independent DNA-binding protein which has previously been characterised as an adhesion molecule required for extra-pulmonary dissemination...
October 19, 2023: Journal of Biological Chemistry
#6
JOURNAL ARTICLE
Gunjan Kumar, Ashish Bhalla, Aparna Mukherjee, Alka Turuk, Arunansu Talukdar, Subhasis Mukherjee, Pankaj Bhardwaj, Geetha R Menon, Damodar Sahu, Puspender Misra, Lokesh Kumar Sharma, Ritin Mohindra, Samita S, Vikas Suri, Himadri Das, Debasis Sarkar, Soumyadeep Ghosh, Priyanka Ghosh, Moumita Dutta, Shreetama Chakraborty, Deepak Kumar, Manoj Kumar Gupta, Akhil Dhanesh Goel, Tridip Dutta Baruah, Pankaj Kumar Kannauje, Arvind Kumar Shukla, Janakkumar R Khambholja, Amit Patel, Nitesh Shah, Sourin Bhuniya, Manoj Kumar Panigrahi, Prasanta Raghab Mohapatra, Ashish Pathak, Ashish Sharma, Mary John, Kiranpreet Kaur, Vijay Nongpiur, Star Pala, Sachin K Shivnitwar, Bobba Rohil Krishna, Naveen Dulhani, Balkishan Gupta, Jigyasa Gupta, Sudhir Bhandari, Abhishek Agrawal, H K Aggarwal, Deepak Jain, Arti D Shah, Parshwa Naik, Manisha Panchal, Mayank Anderpa, Nyanthung Kikon, Christina Nzani Humtsoe, Nikita Sharma, Rajaat Vohra, Lipilekha Patnaik, Jagdish Prasad Sahoo, Rajnish Joshi, Arun Kokane, Yogiraj Ray, Kruti Rajvansh, Hemang M Purohit, Nehal M Shah, Arun Madharia, Simmi Dube, Neha Shrivastava, Sushila Kataria, Mohammad Shameem, Nazish Fatima, Saumitra Ghosh, Avijit Hazra, Himanshu D, Veeresh B Salgar, Santosh Algur, Kala Yadhav M L, Pavan Kumar M, Samiran Panda, Mendu Vishnu Vardhana Rao, Balram Bhargava
INTRODUCTION: The effects of COVID-19 infection persist beyond the active phase. Comprehensive description and analysis of the post COVID sequelae in various population groups are critical to minimise the long-term morbidity and mortality associated with COVID-19. This analysis was conducted with an objective to estimate the frequency of post COVID sequelae and subsequently, design a framework for holistic management of post COVID morbidities. METHODS: Follow-up data collected as part of a registry-based observational study in 31 hospitals across India since September 2020-October 2022 were used for analysis...
October 2023: BMJ Global Health
#7
JOURNAL ARTICLE
Shriya Goel, Taruna Kaura, Kamlesh Bisht, Jasleen Kaur, Abhishek Mewara, P V M Lakshmi, Gagandeep Singh Grover, Manisha Biswal
BACKGROUND: Changing climatic conditions and invasion of ticks in urban areas have led to a greater number of cases of tick-borne diseases, thus, becoming a matter of increasing concern. Tick borne rickettsioses are one of the important emerging diseases worldwide. Knowledge of epidemiology of the vector and pathogen in the community is essential in order to understand and prevent the transmission of the disease to healthy population. METHODS: In our present study, we trapped rodents in selected areas of Chandigarh and Punjab in north India...
September 7, 2023: Indian Journal of Medical Microbiology
#8
JOURNAL ARTICLE
Manisha Goel, Jennifer A Bennett
No abstract text is available yet for this article.
September 1, 2023: International Journal of Gynecological Cancer
#9
JOURNAL ARTICLE
Yifu Han, Pragya Goel, Jiawen Chen, Sarah Perry, Nancy Tran, Samantha Nishimura, Manisha Sanjani, Chun Chien, Dion Dickman
Ionotropic glutamate receptors (GluRs) are targets for modulation in Hebbian and homeostatic synaptic plasticity and are remodeled by development, experience, and disease. We have probed the impact of synaptic glutamate levels on the two postsynaptic GluR subtypes at the Drosophila neuromuscular junction, GluRA and GluRB. We first demonstrate that GluRA and GluRB compete to establish postsynaptic receptive fields, and that proper GluR abundance and composition can be orchestrated in the absence of any synaptic glutamate release...
July 11, 2023: Cell Reports
#10
MULTICENTER STUDY
Suman Chaurasia, Pratima Anand, Akash Sharma, Sushma Nangia, Adhi Sivam, Kajal Jain, Rajni Gaind, Ravinder Kaur, Apurba S Sastry, Arti Kapil, Meenakshi Bhatt, Meetu Salhan, Ajay Dudeja, Nishad Plakkal, Ankit Verma, Manisha Jain, Sonal Saxena, Sarita Mohapatra, Archana Kashyap, Srishti Goel, Sindhu Sivanandan, Sugandha Arya, Savita Saini, Tapish Pande, Sumita Saluja, Monica Sharma, Sreenivas Vishnubhatla, Harish Chellani, M Jeeva Sankar, Ramesh Agarwal
INTRODUCTION: It is unclear if serum procalcitonin (PCT) estimated at sepsis suspicion can help detect culture-positive sepsis in neonates. We evaluated the diagnostic performance of PCT in culture-positive sepsis in neonates. METHODS: This was a prospective study (February 2016 to September 2020) conducted in four level-3 units in India. We enrolled neonates suspected of sepsis in the first 28 days of life. Neonates with birth weight <750 g, asphyxia, shock, and major malformations were excluded...
2023: Neonatology
#11
REVIEW
Sivanantham Krishnamoorthi, Shriya Goel, Jasleen Kaur, Kamlesh Bisht, Manisha Biswal
Rickettsial diseases (RD) are widely reported all over the world. Scrub typhus (ST) is a major tropical infection which is well documented all over India. Therefore, the index of suspicion of scrub typhus is high among physicians with regard to patients presenting with acute febrile illness (AFI) and acute undifferentiated febrile illness (AUFI) in India. Rickettsial diseases other than ST (non-ST RDs), which include spotted fever group (SFG) rickettsioses and typhus group (TG) rickettsioses are not uncommon in India, but the index of suspicion is not as high as ST unless there is a history of the presence of fever with rashes and/or recent arthropod bites...
May 16, 2023: Tropical Medicine and Infectious Disease
#12
JOURNAL ARTICLE
Pallavi Gulati, Ashish Singh, Manisha Goel, Swati Saha
DNA methylation events mediated by orphan methyltransferases modulate various cellular processes like replication, repair and transcription. Bacteria and archaea also harbor DNA methyltransferases that are part of restriction-modification systems, which serve to protect the host genome from being cleaved by the cognate restriction enzyme. While DNA methylation has been exhaustively investigated in bacteria it remains poorly understood in archaea. Picrophilus torridus is a euryarchaeon that can thrive under conditions of extremely low pH (0...
2023: Frontiers in Microbiology
#13
Aarti Yadav, Varshni Sharma, Jyoti Pal, Pallavi Gulati, Manisha Goel, Udita Chandra, Neha Bansal, Swati Saha
[This corrects the article DOI: 10.1371/journal.ppat.1008190.].
March 2023: PLoS Pathogens
#14
JOURNAL ARTICLE
Nikita Ray, Rahul Kumar Vishwakarma, Aakriti Jain, Manish Kumar, Manisha Goel
In early 1990s, several proteins were shown to depend on additional stretches of polypeptide (termed as prosequence/prodomain) for their folding. These regions of the protein were often termed as IMCs (Intra Molecular Chaperones), since they would be cleaved from the mature folded protein eventually. Such proteins were hypothesized to face a kinetic barrier to their folding, which was probably lowered by the prosequences. In last three decades, numerous examples of such proteins have accumulated in literature...
February 22, 2023: Journal of Molecular Biology
#15
JOURNAL ARTICLE
Krithika Rangarajan, Vishnu Prasad Pulappadi, Prabudh Goel, Manisha Jana, Raju Sharma, Shivanand Gamanagatti, Minu Bajpai, Devasenathipathy Kandasamy
AIMS: The conventional Seldinger and trocar techniques of percutaneous nephrostomy (PCN) have inherent limitations in infants and younger children. We studied the role of a novel coaxial technique of PCN in children under the age of 5 years in comparison to the conventional techniques. MATERIALS AND METHODS: This was a single-center feasibility trial based on 24 consecutive patients ( n = 24 kidneys) under the age of 5 years, conducted over 12 months, substratified into Group I ( n = 10): PCN with conventional Seldinger ( n = 2) and trocar ( n = 8) techniques and Group II ( n = 14): PCN with proposed coaxial technique...
2022: Journal of Indian Association of Pediatric Surgeons
#16
JOURNAL ARTICLE
Sarah Perry, Yifu Han, Chengjie Qiu, Chun Chien, Pragya Goel, Samantha Nishimura, Manisha Sajnani, Andreas Schmid, Stephan J Sigrist, Dion Dickman
Presynaptic homeostatic plasticity (PHP) adaptively enhances neurotransmitter release following diminished postsynaptic glutamate receptor (GluR) functionality to maintain synaptic strength. While much is known about PHP expression mechanisms, postsynaptic induction remains enigmatic. For over 20 years, diminished postsynaptic Ca2+ influx was hypothesized to reduce CaMKII activity and enable retrograde PHP signaling at the Drosophila neuromuscular junction. Here, we have interrogated inductive signaling and find that active CaMKII colocalizes with and requires the GluRIIA receptor subunit...
December 10, 2022: Nature Communications
#17
REVIEW
Manisha Goel, Anne Eugster, Johannes Schetelig, Ezio Bonifacio, Martin Bornhäuser, Cornelia S Link-Rachner
Graft-versus-host disease (GvHD) remains one of the major complications following allogeneic haematopoietic stem cell transplantation (allo-HSCT). GvHD can occur in almost every tissue, with the skin, liver, and intestines being the mainly affected organs. T cells are implicated in initiating GvHD. T cells identify a broad range of antigens and mediate the immune response through receptors on their surfaces (T cell receptors, TCRs). The composition of TCRs within a T cell population defines the TCR repertoire of an individual, and this repertoire represents exposure to self and non-self proteins...
March 2023: Bone Marrow Transplantation
#18
Manisha Madhai Beck, Susanna Thomas, S Sowmya, Ashish Goel, Sumita Danda
Niemann-Pick (NPD) is a rare autosomal recessive disease, caused by deficiency of acid sphingomyelinase enzyme leading to accumulation of lipids mainly in the reticuloendothelial system and lungs. We describe the case of a 29-year-old primigravida, recently diagnosed with NPD type B. At initial evaluation, her platelets were normal, liver enzymes slightly elevated and splenomegaly on scan. Pregnancy care was by a multidisciplinary team which routinely monitored her liver and pulmonary functions along with platelets...
December 2022: Journal of Obstetrics and Gynaecology of India
#19
JOURNAL ARTICLE
Mahip K Verma, Charudatt Samant, Ramesh Kale, Sukanya Patra, Nilesh Mahajan, Milind K Gholve, Ajitkumar Marisetti, Brahmam Sunkara, Aditya Naik, Manisha Shingare, Madhusudhan Reddy, Anand M Bokare, Atul Akarte, Sarita Koul, Prashant B Nigade, Vinod B Patil, Dipak Modi, Prajakta Ahirrao, Shashikant Pawar, Sandip Kuldharan, Lal Dinchhana, Maneesh Mehta, Jayasagar Gundu, Nirmal Jana, Prashant Vidhate, Sachin Jaysing Mahangare, Manojkumar R Shukla, Rajan N Goel, Mandar Bhonde, Rajender Kumar Kamboj, Venkata P Palle
Phosphoinositide 3-kinase (PI3K) pathway mediates key signaling events downstream to B-cell receptor (BCR) for survival of mature B-cells, and overexpression or overactivation of PI3Kδ is crucial for B-cell malignancies such as diffuse large B-cell lymphoma (DLBCL). Small molecule PI3Kδγ inhibitors, with a known potential to reduce activated B-cell (ABC)-DLBCL transformation, form an important class of therapeutics approved for follicular lymphoma (FL), chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL)...
December 31, 2022: Biochemical and Biophysical Research Communications
#20
JOURNAL ARTICLE
Archana Sharma, Vineeta Kaushik, Manisha Goel
l-Asparaginase catalyzes the hydrolysis of l-asparagine to aspartic acid and ammonia and is used in the medical and food industries. In this investigation, from the proteomes of 176 archaeal organisms (with completely sequenced genomes), 116 homologs of l-asparaginase were obtained from 86 archaeal organisms segregated into Asp1, Asp2, IaaA, Asp2like1, and Asp2like2 families based on the conserved domain. The similarities and differences in the structure of selected representatives from each family are discussed...
November 15, 2022: ACS Omega
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