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https://www.readbyqxmd.com/read/28928073/timing-of-food-intake-sounding-the-alarm-about-metabolic-impairments-a-systematic-review
#1
REVIEW
Beccuti Guglielmo, Monagheddu Chiara, Evangelista Andrea, Ciccone Giovannino, Broglio Fabio, Soldati Laura, Bo Simona
Growing evidence points to an association between timing of food intake and obesity in humans, raising the question if when to eat matters as much as what and how much to eat. Based on the new definition of obesity as a chronobiological disease, an unusual or late meal timing represent a circadian chronodisruption, leading to metabolic impairments. Preliminary data from cross-sectional and experimental studies suggest that changes in meal timing can influence obesity and success of weight loss therapy, independently from total energy intake, dietary composition and estimated energy expenditure...
September 16, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28912826/can-yesterday-s-smoking-research-inform-today-s-shiftwork-research-epistemological-consequences-for-exposures-and-doses-due-to-circadian-disruption-at-and-off-work
#2
Thomas C Erren, Philip Lewis
In 1950, landmark epidemiology studies by Wynder & Graham and Doll & Hill contributed to identifying smoking as a potent carcinogen. In 2007, IARC classified shiftwork involving circadian disruption (CD) as probably carcinogenic; however, epidemiological evidence in regards to the carcinogenicity of shiftwork that involves nightwork is conflicting. We hypothesize that shiftwork research is lacking chronobiological and methodological rigor and that lessons can be learned from comparison with smoking research...
2017: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/28904295/multidirectional-analyses-of-hepatic-chronotoxicity-induced-by-cadmium-in-mice
#3
Nobuhiko Miura, Hiroki Yoshioka, Atsushige Ashimori, Katsumi Ohtani, Tatsuya Hasegawa, Gi-Wook Hwang, Masayuki Ikeda, Tsunemasa Nonogaki
The expression levels or activities of biological defense factors can fluctuate daily following biological rhythms. We have focused on the relationship between injection timing and the degree of toxicity of cadmium (Cd) to promote the concept of "chronotoxicology," which introduces chronobiology to the field of toxicology. Our previous studies have clearly indicated that Cd may be subject to chronotoxicity. In this report, to confirm the character of the Cd-induced chronotoxicity, we performed multidirectional examinations...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28894915/chronobiological-theories-of-mood-disorder
#4
Nevin F W Zaki, David Warren Spence, Ahmed S BaHammam, Seithikurippu R Pandi-Perumal, Daniel P Cardinali, Gregory M Brown
Major depressive disorder (MDD) remains the most prevalent mental disorder and a leading cause of disability, affecting approximately 100 million adults worldwide. The disorder is characterized by a constellation of symptoms affecting mood, anxiety, neurochemical balance, sleep patterns, and circadian and/or seasonal rhythm entrainment. However, the mechanisms underlying the association between chronobiological parameters and depression remain unknown. A PubMed search was conducted to review articles from 1979 to the present, using the following search terms: "chronobiology," "mood," "sleep," and "circadian rhythms...
September 11, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28893103/what-s-next-for-chronobiology-and-drug-discovery
#5
Zheng Chen
No abstract text is available yet for this article.
September 11, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28884892/basic-research-chronobiology-ontogeny-and-clinical-sleep-medicine
#6
EDITORIAL
Dieter Riemann
No abstract text is available yet for this article.
October 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28868955/neurogenetics-of-drosophila-circadian-clock-expect-the-unexpected
#7
Patricia Jarabo, Francisco A Martin
Daily biological rhythms (i.e. circadian) are a fundamental part of animal behavior. Numerous reports have shown disruptions of the biological clock in neurodegenerative disorders and cancer. In the latter case, only recently we have gained insight into the molecular mechanisms. After 45 years of intense study of the circadian rhtythms, we find surprising similarities among species on the molecular clock that governs biological rhythms. Indeed, Drosophila is one of the most widely used models in the study of chronobiology...
September 4, 2017: Journal of Neurogenetics
https://www.readbyqxmd.com/read/28865786/a-journey-into-the-science-of-cardiovascular-chronobiology
#8
EDITORIAL
Roberto Manfredini, Eduardo Bossone
No abstract text is available yet for this article.
October 2017: Heart Failure Clinics
https://www.readbyqxmd.com/read/28865781/sex-and-circadian-periodicity-of-cardiovascular-diseases-are-women-sufficiently-represented-in-chronobiological-studies
#9
REVIEW
Roberto Manfredini, Raffaella Salmi, Rosaria Cappadona, Fulvia Signani, Stefania Basili, Niki Katsiki
Women are often excluded/underrepresented in clinical trials; sometimes, the number of men/women participants or separate analysis by sex are not reported. A robust body of evidence demonstrated that several life-threatening acute cardiovascular diseases, for example, acute myocardial infarction, sudden cardiac death, cardiac arrest, rupture or dissection of aortic aneurysms, and stroke, exhibit a circadian periodicity with a morning peak. An analysis of 20 years of chronobiologic studies (44% of them, accounting for 85% of total cases, with separate analysis by sex) confirmed that morning hours are a critical time of onset of acute cardiovascular diseases in men and women...
October 2017: Heart Failure Clinics
https://www.readbyqxmd.com/read/28865779/chronobiology-of-acute-aortic-syndromes
#10
REVIEW
Hasan K Siddiqi, Eduardo Bossone, Reed E Pyeritz, Kim A Eagle
Acute aortic syndromes are highly morbid conditions that require prompt diagnosis and management. Aortic dissections have rhythmic patterns, with notable peaks at certain points in every 24 hours as well as weekly and seasonal variations. Several retrospective studies have assessed the chronobiology of acute aortic dissections and there seems to be a winter seasonal peak and morning daily peak in incidence. Although the pathophysiology of this chronobiology is unclear, there are several environmental and physiologic possibilities...
October 2017: Heart Failure Clinics
https://www.readbyqxmd.com/read/28865778/chronobiologic-aspects-of-venous-thromboembolism
#11
REVIEW
Chiara Fantoni, Francesco Dentali, Walter Ageno
In recent years, several studies have consistently described the chronobiologic aspects of many cardiovascular diseases. Several studies have also assessed the circadian and circannual patterns of occurrence and mortality of deep vein thrombosis and pulmonary embolism, but the results have been less univocal. Different mechanisms have been proposed to explain these possible patterns, including oscillation of coagulation proteins, the role of meteorologic parameters, and air pollution. This article summarizes the available evidence on chronobiologic aspects of venous thromboembolism and discusses the casual mechanism...
October 2017: Heart Failure Clinics
https://www.readbyqxmd.com/read/28865126/circadian-control-of-pain-and-neuroinflammation
#12
REVIEW
Julia P Segal, Kaitlyn A Tresidder, Charvi Bhatt, Ian Gilron, Nader Ghasemlou
The importance of a neuroinflammatory response to the development and maintenance of inflammatory and neuropathic pain have been highlighted in recent years. Inflammatory cells contributing to this response include circulating immune cells such as monocytes, T and B lymphocytes, and neutrophils, as well as microglia in the central nervous system. Pain signals are transmitted via sensory neurons in the peripheral nervous system, which express various receptors and channels that respond to mediators secreted from these inflammatory cells...
September 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28862076/timing-the-microbes-the-circadian-rhythm-of-the-gut-microbiome
#13
Xue Liang, Garret A FitzGerald
The mammalian circadian clock system, which includes the master clock and peripheral clocks, times different biological processes in reaction to external cues, such as the light-dark cycle. However, the chronobiology of prokaryotic cells is less well understood, except for in cyanobacteria. The recent blooming of gut microbiome research has revealed a critical role for the trillions of microbes residing in the vertebrate gut in determining both health and disease in the host. The question of whether the gut microbiome exhibits circadian oscillation and how it synchronizes with the host circadian clock has attracted considerable interest...
August 1, 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/28843902/relationship-between-chronobiological-thyrotropin-and-prolactin-responses-to-protirelin-trh-and-suicidal-behavior-in-depressed-patients
#14
Fabrice Duval, Marie-Claude Mokrani, Alexis Erb, Felix Gonzalez Opera, Cécile Calleja, Véronique Paris
BACKGROUND: So far, investigations of the relationships between suicidality and the activity of the thyrotropic and lactotropic axes are scarce and have yielded conflicting results. METHODS: We studied the thyrotropin (TSH) and prolactin (PRL) responses to 0800h and 2300h protirelin (TRH) stimulation tests, carried out on the same day, in 122 euthyroid DSM-5 major depressed inpatients with suicidal behavior disorder (SBD) (either current [n=71], or in early remission [n=51]); and 50 healthy hospitalized controls...
July 28, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28799779/melatonin-intake-and-potential-chronobiological-effects-on-human-health
#15
Ana Luiza Gomes Domingos, Helen Hermana Miranda Hermsdorff, Josefina Bressan
Melatonin is an indolamine with a recognized chronobiotic role. In turn, the supplementation of melatonin through capsules has been shown to be efficient in the modulation of inflammatory markers, oxidative stress, as well as in the control of hypertension and metabolic syndrome. However, the science of nutrition is interested in the study of the food sources of this hormone and its possible therapeutic effects. Thus, this review aimed to identify and present scientific papers that quantified melatonin in foods and evaluated its application in intervention studies...
August 11, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28782461/a-meta-analysis-of-monthly-variation-in-occurrence-of-abdominal-aortic-aneurysm-rupture
#16
Hisato Takagi, Tomo Ando, Takuya Umemoto
BACKGROUND: We performed a meta-analysis to assess the presence of an annual rhythmic variability of ruptured abdominal aortic aneurysm (RAAA) onset. PATIENTS AND METHODS: Eligible studies were observational studies enrolling patients with RAAA and reporting monthly incidence of RAAA. Study-specific estimates, i. e. monthly incidence of RAAA, were combined using the random-effects model. Chronobiological analysis was performed by applying a partial Fourier series to pooled monthly incidence by using the weighted least-squares method...
August 7, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28780783/implications-of-circadian-rhythm-in-dopamine-and-mood-regulation
#17
REVIEW
Jeongah Kim, Sangwon Jang, Han Kyoung Choe, Sooyoung Chung, Gi Hoon Son, Kyungjin Kim
Mammalian physiology and behavior are regulated by an internal time-keeping system, referred to as circadian rhythm. The circadian timing system has a hierarchical organization composed of the master clock in the suprachiasmatic nucleus (SCN) and local clocks in extra-SCN brain regions and peripheral organs. The circadian clock molecular mechanism involves a network of transcription-translation feedback loops. In addition to the clinical association between circadian rhythm disruption and mood disorders, recent studies have suggested a molecular link between mood regulation and circadian rhythm...
July 31, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28777368/-melatonin-known-problems-and-perspectives-of-clinical-usage
#18
A V Zakharov, E V Khivintseva, V F Pytin, M S Sergeeva, O I Antipov
The article discusses well-known and ongoing studies of mechanisms of action of melatonin. The main clinical effects of melatonin are discussed. The emphasis on the chronobiological effect of melatonin, its adaptogenic and anti-carcinogenic properties has been done in the article. The most frequent manifestations of epiphyseal melatonin deficiency are various functional disorders in the form of insomnia, anxiety or depressive disorders. Recommendations on the effective use of melatonin in its deficiency due to pathology are given...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28775132/shift-work-that-involves-circadian-disruption-and-breast-cancer-a-first-application-of-chronobiological-theory-and-the-consequent-challenges
#19
Lin Fritschi, J Valérie Groß, Ursula Wild, Jane S Heyworth, Deborah C Glass, Thomas C Erren
OBJECTIVES: In 2007, the International Agency for Research on Cancer classified shift work involving circadian disruption (CD) as probably carcinogenic to humans. Circadian disruption could be conceptualised as the overlap of activity, such as work, with an individual's biological night. The latter can be approximated from a worker's chronotype (or morning/evening preference). Few previous studies have taken chronotype into account when assessing CD caused by shift work. Our objective was to test the hypothesis that women working during their biological night would be at increased risk of breast cancer...
August 3, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28669378/night-work-and-the-risk-of-depression
#20
Peter Angerer, Renate Schmook, Irina Elfantel, Jian Li
BACKGROUND: Working the night shift interferes with the circadian chronobiological rhythm, causing sleep disturbances, fatigue, and diminished wellbeing, and increases the risk of serious disease. The question whether night work increases the risk of depression has not been adequately studied to date. METHODS: We carried out a systematic, broadly conceived literature search in the PubMed, Scopus, PsycINFO, and PSYNDEX databases and the Medpilot search portal on the topic of nighttime shift work and mental illness...
July 16, 2017: Deutsches Ärzteblatt International
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