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https://www.readbyqxmd.com/read/27915476/translational-research-for-pediatric-lower-urinary-tract-dysfunction
#1
REVIEW
Akihiro Kanematsu
This review provides a comprehensive view of translational research aimed at elucidating the pathophysiology of pediatric lower urinary tract dysfunction (LUTD). A web search was conducted according to combinations of keywords, and the significance of each article was defined by the author. The dramatic evolution of the mass analysis method of genomes, transcripts, and proteins has enabled a comprehensive analysis of molecular events underlying diseases, and these methodologies have also been applied to pediatric LUTD...
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27907092/unconjugated-bile-acids-influence-expression-of-circadian-genes-a-potential-mechanism-for-microbe-host-crosstalk
#2
Kalaimathi Govindarajan, John MacSharry, Patrick G Casey, Fergus Shanahan, Susan A Joyce, Cormac G M Gahan
Disruptions to circadian rhythm in mice and humans have been associated with an increased risk of obesity and metabolic syndrome. The gut microbiota is known to be essential for the maintenance of circadian rhythm in the host suggesting a role for microbe-host interactions in the regulation of the peripheral circadian clock. Previous work suggested a role for gut bacterial bile salt hydrolase (BSH) activity in the regulation of host circadian gene expression. Here we demonstrate that unconjugated bile acids, known to be generated through the BSH activity of the gut microbiota, are potentially chronobiological regulators of host circadian gene expression...
2016: PloS One
https://www.readbyqxmd.com/read/27890490/fragmentation-of-daily-rhythms-associates-with-obesity-and-cardiorespiratory-fitness-in-adolescents-the-helena-study
#3
Marta Garaulet, Antonio Martinez-Nicolas, Jonatan R Ruiz, Kenn Konstabel, Idoia Labayen, Marcela González-Gross, Ascensión Marcos, Dénes Molnar, Kurt Widhalm, Jose Antonio Casajús, Stefaan De Henauw, Anthony Kafatos, Christina Breidenassel, Michael Sjöström, Manuel J Castillo, Luis A Moreno, Juan A Madrid, Francisco B Ortega
BACKGROUND & AIMS: Chronobiology studies periodic changes in living organisms and it has been proposed as a promising approach to investigate obesity. We analyze the association of the characteristics of the rest-activity rhythms with obesity, cardiorespiratory fitness and metabolic risk in adolescents from nine European countries. METHODS: 1044 adolescents (12.5-17.5 y) were studied. Circadian health was evaluated by actigraphy with accelerometers (Actigraph GT1M)...
November 5, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27858294/sleep-quality-morningness-eveningness-preference-mood-profile-and-levels-of-serum-melatonin-in-migraine-patients-a-case-control-study
#4
Hasan Hüseyin Kozak, Murat Boysan, Ali Ulvi Uca, Adem Aydın, İbrahim Kılınç, Emine Genç, Mustafa Altaş, Dilara Cari Güngör, Keziban Turgut, Nejla Özer
The melatonin as the pineal gland's secretory product is implicated in the pathophysiology of migraine. Melatonin has critical functions in human physiology, and research underscores the importance of melatonin in circadian rhythm, sleep, and mood regulation. Clinical observations have indicated that migraine attacks have a seasonal, menstrual, and circadian timing, suggesting that chronobiological mechanisms and their alterations may causally involve in the etiology of the disease. However, the topic has received relatively little attention in the migraine literature...
November 17, 2016: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/27814712/chronobiology-sleep-related-risk-factors-and-light-therapy-in-perinatal-depression-the-life-on-project
#5
Simone Baiardi, Fabio Cirignotta, Alessandro Cicolin, Corrado Garbazza, Armando D'Agostino, Orsola Gambini, Alessandra Giordano, Mariapaola Canevini, Elena Zambrelli, Anna Maria Marconi, Susanna Mondini, Stefan Borgwardt, Christian Cajochen, Nicola Rizzo, Mauro Manconi
BACKGROUND: Perinatal depression (PND) has an overall estimated prevalence of roughly 12 %. Untreated PND has significant negative consequences not only on the health of the mothers, but also on the physical, emotional and cognitive development of their children. No certain risk factors are known to predict PND and no completely safe drug treatments are available during pregnancy and breastfeeding. Sleep and depression are strongly related to each other because of a solid reciprocal causal relationship...
November 4, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27800654/biological-hypotheses-and-biomarkers-of-bipolar-disorder
#6
REVIEW
Ekaterina Sigitova, Zdeněk Fišar, Jana Hroudová, Tereza Cikánková, Jiří Raboch
The most common mood disorders are major depressive disorders and bipolar disorders. The pathophysiology of bipolar disorder is complex, multifactorial, and not fully understood. Creation of new hypotheses in the field gives impetus for studies and searching new biomarkers of the bipolar disorder. Conversely, new biomarkers facilitate not only diagnosis of a disorder and monitoring of biological effects of treatment, but also formulation of new hypotheses of the causes and pathophysiology of the bipolar disorder...
October 31, 2016: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27771728/chronobiology-of-aging-a-mini-review
#7
Germaine Cornelissen, Kuniaki Otsuka
Aging is generally associated with weakening of the circadian system. The circadian amplitude is reduced and the circadian acrophase becomes more labile, tending to occur earlier with advancing age. As originally noted by Franz Halberg, similar features are observed in the experimental laboratory after bilateral lesioning of the suprachiasmatic nuclei, suggesting the involvement of clock genes in the aging process as they are in various disease conditions. Recent work has been shedding light on underlying pathways involved in the aging process, with the promise of interventions to extend healthy life spans...
October 22, 2016: Gerontology
https://www.readbyqxmd.com/read/27715325/social-jet-lag-chronotype-and-body-mass-index-in-14-17-year-old-adolescents
#8
Susan Kohl Malone, Babette Zemel, Charlene Compher, Margaret Souders, Jesse Chittams, Aleda Leis Thompson, Allan Pack, Terri H Lipman
The relationship between sleep duration and obesity in adolescents is inconclusive. This may stem from a more complex relationship between sleep and obesity than previously considered. Shifts toward evening preferences, later sleep-wake times and irregular sleep-wake patterns are typical during adolescence but their relationship to body mass index (BMI) has been relatively unexplored. This cross-sectional study examined associations between sleep duration, midpoint of sleep and social jet lag (estimated from 7 days of continuous actigraphy monitoring), and morningness/eveningness with BMIs (BMI z-scores) and waist-to-height ratios in 14-17-year-old adolescents...
August 11, 2016: Chronobiology International
https://www.readbyqxmd.com/read/27708112/unexpected-geographic-variability-of-the-free-running-period-in-the-linden-bug-pyrrhocoris-apterus
#9
Lenka Pivarciova, Hanka Vaneckova, Jan Provaznik, Bulah Chia-Hsiang Wu, Martin Pivarci, Olga Peckova, Olga Bazalova, Stepan Cada, Petr Kment, Joanna Kotwica-Rolinska, David Dolezel
Circadian clocks keep organisms in synchrony with external day-night cycles. The free running period (FRP) of the clock, however, is usually only close to-not exactly-24 h. Here, we explored the geographical variation in the FRP of the linden bug, Pyrrhocoris apterus, in 59 field-lines originating from a wide variety of localities representing geographically different environments. We have identified a remarkable range in the FRPs between field-lines, with the fastest clock at ~21 h and the slowest close to 28 h, a range comparable to the collections of clock mutants in model organisms...
October 5, 2016: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/27701007/time-is-ripe-maturation-of-metabolomics-in-chronobiology
#10
Seth D Rhoades, Arjun Sengupta, Aalim M Weljie
Sleep and circadian rhythms studies have recently benefited from metabolomics analyses, uncovering new connections between chronobiology and metabolism. From untargeted mass spectrometry to quantitative nuclear magnetic resonance spectroscopy, a diversity of analytical approaches has been applied for biomarker discovery in the field. In this review we consider advances in the application of metabolomics technologies which have uncovered significant effects of sleep and circadian cycles on several metabolites, namely phosphatidylcholine species, medium-chain carnitines, and aromatic amino acids...
October 1, 2016: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/27699758/-healthy-sleep-evidence-and-guidelines-for-action-official-document-of-the-spanish-sleep-society
#11
M Merino-Andreu, A Alvarez-Ruiz de Larrinaga, J A Madrid-Perez, M A Martinez-Martinez, F J Puertas-Cuesta, A J Asencio-Guerra, O Romero Santo-Tomas, M J Jurado-Luque, F J Segarra-Isern, T Canet-Sanz, P Gimenez-Rodriguez, J Teran-Santos, M L Alonso-Alvarez, D Garcia-Borreguero Diaz-Varela, B Barriuso-Esteban
One of the main objectives of the Spanish Sleep Society is to promote healthy sleep in both the general population and in health professionals. This document aims to conduct a review of the current scientific literature on sleep habits that can serve as the basis on which to establish a set of general recommendations, regarding healthy sleep, for use by the general population in Spain as well as to identify the main challenges faced by research into sleep habits. The document has been developed by a multidisciplinary team made up of members of the Spanish Sleep Society who are experts in paediatric sleep medicine, clinical neurophysiology, pulmonology, neurology, chronobiology, physiology and psychology...
October 3, 2016: Revista de Neurologia
https://www.readbyqxmd.com/read/27699644/chronotherapy-intuitive-sound-founded%C3%A2-but-not-broadly-applied
#12
Julia M Selfridge, Tetsuya Gotoh, Samuel Schiffhauer, JingJing Liu, Philip E Stauffer, Andrew Li, Daniel G S Capelluto, Carla V Finkielstein
Circadian rhythms are a collection of endogenously driven biochemical, physiological, and behavioral processes that oscillate in a 24-h cycle and can be entrained by external cues. Circadian clock molecules are responsible for the expression of regulatory components that modulate, among others, the cell's metabolism and energy consumption. In clinical practice, the regulation of clock mechanisms is relevant to biotransformation of therapeutics. Accordingly, xenobiotic metabolism and detoxification, the two processes that directly influence drug effectiveness and toxicity, are direct manifestations of the daily oscillations of the cellular and biochemical processes taking place within the gastrointestinal, hepatic/biliary, and renal/urologic systems...
October 3, 2016: Drugs
https://www.readbyqxmd.com/read/27638023/chronobiology-of-takotsubo-syndrome-and-myocardial-infarction-analogies-and-differences
#13
REVIEW
Roberto Manfredini, Fabio Manfredini, Fabio Fabbian, Raffaella Salmi, Massimo Gallerani, Eduardo Bossone, Abhishek J Deshmukh
Several pathophysiologic factors, not harmful if taken alone, are capable of triggering unfavorable events when presenting together within the same temporal window (chronorisk), and the occurrence of many cardiovascular events is not evenly distributed in time. Both acute myocardial infarction and takotsubo syndrome seem to exhibit a temporal preference in their onset, characterized by variations according to time of day, day of the week, and month of the year, although with both analogies and differences.
October 2016: Heart Failure Clinics
https://www.readbyqxmd.com/read/27617515/hormones-and-clocks-do-they-disrupt-the-locks-fluctuating-estrogen-levels-during-menopausal-transition-may-influence-clock-genes-and-trigger-chronic-telogen-effluvium
#14
Paradi Mirmirani
Chronic telogen effluvium describes the clinical condition noted mostly in middle-aged women of increased, diffuse scalp hair shedding that is prolonged and often presents with a fluctuating course that may continue for years but does not lead to visible hair thinning. Despite its description almost 20 years ago, the underlying pathologic cause of CTE is yet to be identified. However the culmination of research in the field of hair biology and the burgeoning field of chronobiology may lead to exciting breakthroughs in our understanding of CTE...
2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27611743/can-the-circadian-phase-be-estimated-from-self-reported-sleep-timing-in-patients-with-delayed-sleep-wake-phase-disorder-to-guide-timing-of-chronobiologic-treatment
#15
Nicole Lovato, Gorica Micic, Michael Gradisar, Sally A Ferguson, Helen J Burgess, David J Kennaway, Leon Lack
INTRODUCTION: The efficacy of bright light and/or melatonin treatment for Delayed Sleep Wake Phase Disorder (DSWPD) is contingent upon an accurate clinical assessment of the circadian phase. However, the process of determining this circadian phase can be costly and is not yet readily available in the clinical setting. The present study investigated whether more cost-effective and convenient estimates of the circadian phase, such as self-reported sleep timing, can be used to predict the circadian phase and guide the timing of light and/or melatonin treatment (i...
2016: Chronobiology International
https://www.readbyqxmd.com/read/27594289/molecular-characterization-and-chronobiology-of-hypodermosis-in-cattle-slaughtered-in-the-diyarbakir-province-of-turkey
#16
Duygu Neval Sayın İpek
OBJECTIVE: The aim of present study was to investigate the chronobiology and identification of Hypoderma species in cattle slaughtered in the Diyarbakir Province of Turkey. METHODS: In total, 736 hides and subcutaneous tissue of slaughtered cattle were examined for the presence of second- and third-instar larvae in the slaughterhouse between November 2012 and May 2013. Third-instar larvae were collected from the slaughterhouses, and gDNA isolates were examined by PCR-RFLP analysis of the cytochrome c oxidase I (COI) gene of mt-DNA using TaqI enzyme...
December 0: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/27549931/person-directed-non-pharmacological-interventions-for-sleepiness-at-work-and-sleep-disturbances-caused-by-shift-work
#17
REVIEW
Tracy E Slanger, J Valérie Gross, Andreas Pinger, Peter Morfeld, Miriam Bellinger, Anna-Lena Duhme, Rosalinde Amancay Reichardt Ortega, Giovanni Costa, Tim R Driscoll, Russell G Foster, Lin Fritschi, Mikael Sallinen, Juha Liira, Thomas C Erren
BACKGROUND: Shift work is often associated with sleepiness and sleep disorders. Person-directed, non-pharmacological interventions may positively influence the impact of shift work on sleep, thereby improving workers' well-being, safety, and health. OBJECTIVES: To assess the effects of person-directed, non-pharmacological interventions for reducing sleepiness at work and improving the length and quality of sleep between shifts for shift workers. SEARCH METHODS: We searched CENTRAL, MEDLINE Ovid, Embase, Web of Knowledge, ProQuest, PsycINFO, OpenGrey, and OSH-UPDATE from inception to August 2015...
August 23, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27542994/hiccups-attitude-in-otorhinolaryngology-towards-consulting-patients-a-diagnostic-and-therapeutic-approach
#18
Francisco Javier García Callejo, Jaume Redondo Martínez, Tomás Pérez Carbonell, Rafael Monzó Gandía, M Paz Martínez Beneyto, Inés Rincón Piedrahita
INTRODUCTION: Hiccup crises are generally benign and self-limiting, but longer episodes affect quality of life and must be treated. There are recognisable causes that otorhinolaryngologists must know and be aware for diagnosis and therapeutic alternatives. The main expression is a spasmodic glottic noise with characteristic neck alterations. PATIENTS AND METHODS: This was a retrospective study from 1979 with patients suffering persistent or recurrent hiccups. Chronobiology, comorbidity, findings from explorations, therapies and outcomes were noted...
August 16, 2016: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/27538446/genome-wide-profiling-of-24%C3%A2-hr-diel-rhythmicity-in-the-water-flea-daphnia-pulex-network-analysis-reveals-rhythmic-gene-expression-and-enhances-functional-gene-annotation
#19
Samuel S C Rund, Boyoung Yoo, Camille Alam, Taryn Green, Melissa T Stephens, Erliang Zeng, Gary F George, Aaron D Sheppard, Giles E Duffield, Tijana Milenković, Michael E Pfrender
BACKGROUND: Marine and freshwater zooplankton exhibit daily rhythmic patterns of behavior and physiology which may be regulated directly by the light:dark (LD) cycle and/or a molecular circadian clock. One of the best-studied zooplankton taxa, the freshwater crustacean Daphnia, has a 24 h diel vertical migration (DVM) behavior whereby the organism travels up and down through the water column daily. DVM plays a critical role in resource tracking and the behavioral avoidance of predators and damaging ultraviolet radiation...
2016: BMC Genomics
https://www.readbyqxmd.com/read/27538100/epidemiological-study-on-chronotype-among-preschool-children-in-japan-prevalence-sleep-wake-patterns-and-associated-factors
#20
Yuriko Doi, Kaneyoshi Ishihara, Makoto Uchiyama
Our current 24-h society and the weekday-weekend switch of our social clocks may affect young children's sleep and circadian rhythms. However, such evidence is scarce. We conducted a nationwide epidemiological study of sleep and health in preschool children aged 3-5 years attending kindergarten or childcare centers in Japan, using stratified one-stage cluster sampling. The target population was 2 969 627 individuals (as of 1 April 2013). The Children's ChronoType Questionnaire was used to measure chronotypes (morning (M)-type, neither (N)-type and evening (E)-type), and weekday and weekend sleep-wake parameters...
2016: Chronobiology International
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