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https://www.readbyqxmd.com/read/28231628/the-lived-experience-of-recovery-during-the-first-six-months-after-colorectal-cancer-surgery
#1
Jenny Jakobsson, Ewa Idvall, Christine Kumlien
AIMS AND OBJECTIVES: The objective of this study was to describe the lived experience of recovery during the first six months after colorectal cancer surgery. BACKGROUND: Colorectal cancer is the third most common cancer-diagnose worldwide. Early discharge places demands on health care professionals to prepare patients for their return home and to provide them with appropriate support throughout the recovery process. This requires knowledge of what it is like to recover from colorectal cancer surgery...
February 23, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28230891/parathyroid-hormone-serum-concentration-in-central-european-patients-with-non-ischemic-heart-failure-as-a-potential-marker-of-disease-severity-and-poor-prognosis
#2
Grzegorz Marcin Kubiak, Agnieszka Kolaszko, Ewa Nowalany-Kozielska
IntroductionParathyroid hormone (PTH) might be considered as a potential marker of disease severity and worse prognosis in heart failure (HF) patients. ObjectivesTo assess PTH, vitamin D, phosphorus (P) and total calcium (Ca2+) serum concentrations in Central European patients suffering from HF of non-ischemic origin compared to non-HF volunteers.To evaluate potential correlations among the enumerated parameters, established markers of worse prognosis and declared sun exposure. Patients and methodsSerum intact-PTH, 25-OH vitamin D, P and total Ca2+ concentrations were assessed in a group of HF patients and non-HF volunteers...
February 23, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28229255/nordic-walking-training-attenuation-of-oxidative-stress-in-association-with-a-drop-in-body-iron-stores-in-elderly-women
#3
Jakub Kortas, Agnieszka Kuchta, Krzysztof Prusik, Katarzyna Prusik, Ewa Ziemann, Sandra Labudda, Agnieszka Ćwiklińska, Ewa Wieczorek, Maciej Jankowski, Jedrzej Antosiewicz
Excess body iron accumulation and oxidative stress has been associated with ageing. Regular exercise has been shown to reduce oxidative stress and induce some changes in iron metabolism. However, the effects of exercise on both of these parameters have been poorly investigated. In our study, 35 elderly women participated in 12 weeks of Nordic walking (NW) training (three times a week). We demonstrated that the training caused a significant reduction in malondialdehyde advanced oxidation protein products-markers of oxidative stress but had no effects on paraoxonase 1 activity...
February 22, 2017: Biogerontology
https://www.readbyqxmd.com/read/28229161/high-levels-of-latent-antithrombin-in-plasma-from-patients-with-antithrombin-deficiency
#4
María de la Morena-Barrio, Edna Sandoval, Pilar Llamas, Ewa Wypasek, Mara Toderici, José Navarro-Fernández, Agustín Rodríguez-Alen, Nuria Revilla, Raquel López-Gálvez, Antonia Miñano, José Padilla, Belén de la Morena-Barrio, Jorge Cuesta, Javier Corral, Vincente Vincente
Antithrombin is an anticoagulant serpin that efficiently inhibits multiple procoagulant proteases. The cost for the structural flexibility required for this function is the vulnerability to mutations that impact its folding pathway. Most conformational mutations identified in serpins cause polymerisation. Only three mutations in SERPINC1 affecting two residues have been found to favour transformation to the latent conformation of antithrombin, another hyperstable non-anticoagulant form with strong antiangiogenic activity that constitutes 3 % of plasma antithrombin in healthy subjects...
February 23, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28228751/prospects-of-phage-application-in-the-treatment-of-acne-caused-by-propionibacterium-acnes
#5
REVIEW
Ewa Jończyk-Matysiak, Beata Weber-Dąbrowska, Maciej Żaczek, Ryszard Międzybrodzki, Sławomir Letkiewicz, Marzanna Łusiak-Szelchowska, Andrzej Górski
Propionibacterium acnes is associated with purulent skin infections, and it poses a global problem for both patients and doctors. Acne vulgaris (acne) remains a problem due to its chronic character and difficulty of treatment, as well as its large impact on patients' quality of life. Due to the chronic course of the disease, treatment is long lasting, and often ineffective. Currently there are data regarding isolation of P. acnes phages, and there have been numerous studies on phage killing of P. acnes, but no data are available on phage application specifically in acne treatment...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28228471/novel-layers-of-rna-polymerase-iii-control-affecting-trna-gene-transcription-in-eukaryotes
#6
REVIEW
Ewa Leśniewska, Magdalena Boguta
RNA polymerase III (Pol III) transcribes a limited set of short genes in eukaryotes producing abundant small RNAs, mostly tRNA. The originally defined yeast Pol III transcriptome appears to be expanding owing to the application of new methods. Also, several factors required for assembly and nuclear import of Pol III complex have been identified recently. Models of Pol III based on cryo-electron microscopy reconstructions of distinct Pol III conformations reveal unique features distinguishing Pol III from other polymerases...
February 2017: Open Biology
https://www.readbyqxmd.com/read/28225795/multicenter-experiences-in-temporal-bone-cancer-surgery-based-on-89-cases
#7
Małgorzata Wierzbicka, Kazimierz Niemczyk, Antoni Bruzgielewicz, Marcin Durko, Janusz Klatka, Tomasz Kopeć, Ewa Osuch-Wójcikiewicz, Wioletta Pietruszewska, Marcin Szymański, Witold Szyfter
OBJECTIVE: To present outcomes of extensive surgery: lateral, subtotal, total petrosectomies in patients with temporal bone invasion resulting from specific primary cancers. STUDY DESIGN: Retrospective case review. SETTING: Four tertiary referral centers. MATERIAL: 89 patients with cancer of the temporal bone treated between January 2006 and December 2010. INTERVENTION: Multidisciplinary team approach including surgical resection, reconstruction, and postoperative radiotherapy...
2017: PloS One
https://www.readbyqxmd.com/read/28222606/flexible-porphyrinoids
#8
Bartosz Szyszko, Michał J Białek, Ewa Pacholska-Dudziak, Lechosław Latos-Grażyński
This review underscores the conformational flexibility of porphyrinoids, a unique class of functional molecules, starting from the smallest triphyrins(1.1.1) via [18]porphyrins(1.1.1.1) and concluding with a variety of expanded porphyrinoids and heteroporphyrinoids, including the enormous [96]tetracosaphyrin(1.0.1.0.1.0.1.0.1.0.1.0.1.0.1.0.1.0.1.0.1.0.1.0). The specific flexibility of porphyrinoids has been documented as instrumental in the designing or redesigning of macrocyclic frames, particularly in the search for adjustable platforms for coordination or organometallic chemistry, anion binding, or mechanistic switches in molecular devices...
February 22, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28222406/leydig-cell-clustering-and-reinke-crystal-distribution-in-relation-to-hormonal-function-in-adult-patients-with-testicular-dysgenesis-syndrome-tds-including-cryptorchidism
#9
Rikke R Soerensen, Trine H Johannsen, Niels E Skakkebaek, Ewa Rajpert-De Meyts
OBJECTIVE: Testicular dysgenesis syndrome (TDS) comprises testicular germ cell cancer, cryptorchidism and some cases of male infertility and hypospadias, which can be linked to impairment of intrauterine gonadal development. Among histological signs of TDS, large Leydig cell (LC) clusters (micronodules) are frequently present. This study aimed to investigate possible associations of LC micronodules with the presence of Reinke crystals and hormonal function of LCs, the latter primarily reflected by serum concentrations of luteinising hormone (LH) and testosterone, in patients with TDS...
October 2016: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28221965/explanatory-variables-associated-with-campylobacter-and-escherichia-coli-concentrations-on-broiler-chicken-carcasses-during-processing-in-two-slaughterhouses
#10
Ewa Pacholewicz, Arno Swart, Jaap A Wagenaar, Len J A Lipman, Arie H Havelaar
This study aimed at identifying explanatory variables that were associated with Campylobacter and Escherichia coli concentrations throughout processing in two commercial broiler slaughterhouses. Quantative data on Campylobacter and E. coli along the processing line were collected. Moreover, information on batch characteristics, slaughterhouse practices, process performance, and environmental variables was collected through questionnaires, observations, and measurements, resulting in data on 19 potential explanatory variables...
December 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28220912/shift-schedule-work-family-relationships-marital-communication-job-satisfaction-and-health-among-transport-service-shift-workers
#11
Irena Iskra-Golec, Lawrence Smith, Ewa Wilczek-Rużyczka, Patrycja Siemiginowska, Joanna Wątroba
OBJECTIVES: Existing research has documented that shiftwork consequences may depend on the shift system parameters. Fast rotating systems (1-3 shifts of the same kind in a row) and day work have been found to be less disruptive biologically and socially than slower rotating systems and afternoon and night work. The aim of this study was to compare day workers and shift workers of different systems in terms of rotation speed and shifts worked with regard to work-family and family-work positive and negative spillover, marital communication style, job satisfaction and health...
February 21, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28220212/rho-kinase-inhibition-ameliorates-cyclophosphamide-induced-cystitis-in-rats
#12
Andrzej Wróbel, Urszula Doboszewska, Ewa Rechberger, Karol Rojek, Anna Serefko, Ewa Poleszak, Krystyna Skalicka-Woźniak, Jarosław Dudka, Piotr Wlaź
Hemorrhagic cystitis often develops in patients treated with cyclophosphamide (CYP). Studies have indicated that Rho kinase (ROCK) inhibitors may suppress detrusor overactivity symptoms and possess anti-inflammatory properties. The aim of the present study was to investigate whether inhibition of ROCK reduces cystometric and histopathological changes associated with CYP-induced cystitis. The rats received GSK 269962, a ROCK inhibitor, at a dose of 30 mg/kg daily, or vehicle for 7 days. Then, acute chemical cystitis leading to bladder overactivity was induced by CYP injection (200 mg/kg i...
February 21, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28219697/effect-of-salvia-miltiorrhiza-root-extract-on-brain-acetylcholinesterase-and-butyrylcholinesterase-activities-their-mrna-levels-and-memory-evaluation-in-rats
#13
Marcin Ozarowski, Przemyslaw L Mikolajczak, Anna Piasecka, Radoslaw Kujawski, Joanna Bartkowiak-Wieczorek, Anna Bogacz, Michal Szulc, Ewa Kaminska, Malgorzata Kujawska, Agnieszka Gryszczynska, Piotr Kachlicki, Waldemar Buchwald, Andrzej Klejewski, Agnieszka Seremak-Mrozikiewicz
Salvia miltiorrhiza (Lamiaceae), one of the most important and popular plants of traditional medicine of Asia, is used for the prevention and treatment of cardiovascular diseases and in central nervous system disturbances. The main aim of this study was to assess the influence of subchronic (28-fold) administration of Salvia miltiorrhiza root extract (SE, 200mg/kg, p.o.) on behavioural activity and memory of rats and to evaluate the activities of cholinesterases (AChE and BuChE) and gene expression levels of AChE and BuChE as well as of beta-secretase (BACE1) in the hippocampus and frontal cortex in vivo...
February 17, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28219332/the-assessment-of-accessory-mental-foramen-in-a-selected-polish-population-a-cbct-study
#14
Ewa Zmysłowska-Polakowska, Mateusz Radwański, Michał Łęski, Sławomir Ledzion, Monika Łukomska-Szymańska, Michał Polguj
BACKGROUND: Accessory mental foramen (AMF) is a rare anatomical variation. When accessory mental foramen is present, the nerves and vessels that go through the mental foramen (MF) must follow alternative courses and special care must be taken during dental treatment planning. The purpose of this study was to evaluate the occurrence and the location of AMF in a selected Polish population using cone-beam computed tomography (CBCT). METHODS: Two hundred CBCT (105 males and 95 females) examinations were evaluated for the presence of AMFs...
February 20, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28218580/circulating-cathelicidin-ll-37-in-adult-patients-with-pulmonary-infectious-diseases
#15
Karol Majewski, Paulina Żelechowska, Ewa Brzezińska-Błaszczyk
PURPOSE: The antimicrobial peptide cathelicidin LL-37 plays a role in the immune response in the course of lung infections; however, the exact role of LL-37 in defense mechanisms against bacteria within the respiratory tract is has not been precisely described. The aim of our study was to evaluate LL-37 concentrations in the serum of pulmonary tuberculosis (TB) patients, patients with pneumonia caused by Gram-positive and Gram-negative bacteria and to compare them with those of healthy subjects...
February 19, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/28216215/direct-admission-versus-interhospital-transfer-for-primary-percutaneous-coronary-intervention-in-st-segment-elevation-myocardial-infarction
#16
Damian Kawecki, Marek Gierlotka, Beata Morawiec, Michał Hawranek, Mateusz Tajstra, Michał Skrzypek, Wojciech Wojakowski, Lech Poloński, Ewa Nowalany-Kozielska, Mariusz Gąsior
OBJECTIVES: This study sought to assess the influence of direct admission versus transfer via regional hospital to a percutaneous coronary intervention (PCI) center on time delays and 12-month mortality in ST-segment elevation myocardial infarction (STEMI) patients from a real-life perspective. BACKGROUND: Reduction of delays to reperfusion is crucial in a STEMI system of care. However, it is still debated whether direct admission to a PCI center is superior to interhospital transfer in terms of long-term prognosis...
February 9, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28216140/expression-profiles-of-cancer-stem-cell-markers-cd133-cd44-musashi-1-and-epcam-in-the-cardiac-mucosa-barrett-s-esophagus-early-esophageal-adenocarcinoma-advanced-esophageal-adenocarcinoma-sequence
#17
Anna Mokrowiecka, Lothar Veits, Christina Falkeis, Jacek Musial, Radzislaw Kordek, Mariusz Lochowski, Jozef Kozak, Agnieszka Wierzchniewska-Lawska, Michael Vieth, Ewa Malecka-Panas
INTRODUCTION: Barrett's esophagus (BE), which develops as a result of gastroesophageal reflux disease, is a preneoplastic condition for esophageal adenocarcinoma (EAC). A new hypothesis suggests that cancer is a disease of stem cells, however, their expression and pathways in BE - EAC sequence are not fully elucidated yet. AIMS: We used a panel of putative cancer stem cells markers to identify stem cells in consecutive steps of BE-related cancer progression. METHODS: Immunohistochemistry was performed on formalin-fixed, paraffin-embedded blocks from 58 patients with normal cardiac mucosa (n=5), BE (n=14), early EAC (pT1) from mucosal resection (n=17) and advanced EAC (pT1-T4) from postoperative specimens (n=22)...
December 30, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28216089/health-status-and-psychological-distress-among-in-hospital-cardiac-arrest-survivors-in-relation-to-gender
#18
Johan Israelsson, Anders Bremer, Johan Herlitz, Åsa B Axelsson, Tobias Cronberg, Therese Djärv, Marja-Leena Kristofferzon, Ing-Marie Larsson, Gisela Lilja, Katharina S Sunnerhagen, Ewa Wallin, Susanna Ågren, Eva Åkerman, Kristofer Årestedt
AIM: To describe health status and psychological distress among in-hospital cardiac arrest (IHCA) survivors in relation to gender. METHODS: This national register study consists of data from follow-up registration of IHCA survivors 3-6 months post cardiac arrest (CA) in Sweden. A questionnaire was sent to the survivors, including measurements of health status (EQ-5D-5L) and psychological distress (HADS). RESULTS: Between 2013 and 2015, 594 IHCA survivors were included in the study...
February 16, 2017: Resuscitation
https://www.readbyqxmd.com/read/28216084/vitamin-d-supplementation-guidelines
#19
Pawel Pludowski, Michael F Holick, William B Grant, Jerzy Konstantynowicz, Mario R Mascarenhas, Afrozul Haq, Vladyslav Povoroznyuk, Nataliya Balatska, Ana Paula Barbosa, Tatiana Karonova, Ema Rudenka, Waldemar Misiorowski, Irina Zakharova, Alena Rudenka, Jacek Łukaszkiewicz, Ewa Marcinowska-Suchowierska, Natalia Łaszcz, Pawel Abramowicz, Harjit P Bhattoa, Sunil J Wimalawansa
Research carried out during the past two-decades extended the understanding of actions of vitamin D, from regulating calcium and phosphate absorption and bone metabolism to many pleiotropic actions in organs and tissues in the body. Most observational and ecological studies report association of higher serum 25-hydroxyvitamin D [25(OH)D] concentrations with improved outcomes for several chronic, communicable and non-communicable diseases. Consequently, numerous agencies and scientific organizations have developed recommendations for vitamin D supplementation and guidance on optimal serum 25(OH)D concentrations...
February 12, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28215431/global-decrease-in-the-expression-of-signalling-pathways-genes-in-murine-uterus-during-preimplantation-pregnancy
#20
Katarzyna Buska, Anna Ewa Kedzierska, Anna Slawek, Anna Chelmonska-Soyta
Early preimplantation embryo-maternal communication is crucial for the establishment and development of pregnancy. Though the involvement of several candidate genes and proteins in this complex event has been described, the hierarchy of molecular networks governing this communication remains unknown. The primary objective of this study was to determine whether the presence of embryos in the uterine lumen stimulated or inhibited gene expression in the uterine tissue on day 3.5 post coitum. To answer this question, we investigated the gene expression of dedicated signal transduction pathways in the uterus of CD-1 mice during the preimplantation stage of pregnancy and compared this expression to mice with induced pseudopregnancy...
February 15, 2017: Reproductive Biology
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