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https://www.readbyqxmd.com/read/27933602/fish-tales-the-use-of-zebrafish-xenograft-human-cancer-cell-models
#1
REVIEW
Yvette Drabsch, B Ewa Snaar-Jagalska, Peter Ten Dijke
Advances in scientific techniques have provided researchers with exceptional new opportunities to identify and monitor changes between different cancer types, during different stages of progression, between individual tumor cells and in the surrounding stroma. The wealth of information that can be obtained from new scientific techniques places additional requirements on the conventional cancer models. New models that could be used to rapidly access the (potential) functional importance of newly identified (epi)genetic and proteomic changes and test the efficacy on emerging (combinatorial) therapies are desperately required...
December 9, 2016: Histology and Histopathology
https://www.readbyqxmd.com/read/27933341/intragenic-variations-in-btla-gene-influence-mrna-expression-of-btla-gene-in-chronic-lymphocytic-leukemia-patients-and-confer-susceptibility-to-chronic-lymphocytic-leukemia
#2
Lidia Karabon, Anna Partyka, Monika Jasek, Ewa Lech-Maranda, Olga Grzybowska-Izydorczyk, Agnieszka Bojarska-Junak, Edyta Pawlak-Adamska, Anna Tomkiewicz, Tadeusz Robak, Jacek Rolinski, Irena Frydecka
The aim of this study was to determine the association between polymorphisms in gene encoding B- and T-lymphocyte attenuator (BTLA) and susceptibility to chronic lymphocytic leukemia (CLL) and their influence on mRNA expression of BTLA gene in T and B cells from CLL patients (pts.). The following BTLA single-nucleotide polymorphisms (SNPs): rs2705511, rs1982809, rs9288952, rs76844316, rs16859633, rs9288953, rs2705535, rs1844089, rs2705565, rs2633580 were genotyped with use of TaqMan probes in 321 CLL pts. and in 470 controls...
December 8, 2016: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/27931173/cosmetic-wastewater-treatment-by-zvi-h2o2-process
#3
Jan Bogacki, Piotr Marcinowski, Ewa Zapałowska, Justyna Maksymiec, Jeremi Naumczyk
ZVI/H2O2 process was applied for cosmetic wastewater treatment. Two commercial zero valent iron (ZVI) types with different granulation were chosen: Hepure Ferrox PRB and Hepure Ferrox Target. In addition, the pH and stirring method influence on ZVI/H2O2 process efficiency was studied. Wastewater used in experiments was collected from the cosmetic factory located in central Poland, and was pretreated with the use of dissolved air flotation (DAF). The pretreated wastewater was characterized by Chemical Oxygen Demand (COD) of 796 mg/L...
December 9, 2016: Environmental Technology
https://www.readbyqxmd.com/read/27929586/new-methods-general-discussion
#4
Gonzalo Angulo, Raymond Dean Astumian, Vijay Beniwal, Peter G Bolhuis, Christoph Dellago, John Ellis, Bernd Ensing, David R Glowacki, Sharon Hammes-Schiffer, Johannes Kästner, Tony Lelièvre, Nancy Makri, David Manolopoulos, Georg Menzl, Thomas F Miller, Adrian Mulholland, Ewa Anna Oprzeska-Zingrebe, Michele Parrinello, Eli Pollak, Jonny Proppe, Markus Reiher, Jeremy Richardson, Priyadarshi Roy Chowdhury, Eduardo Sanz, Christof Schütte, Dmitry Shalashilin, Rafał Szabla, Srabani Taraphder, Ambuj Tiwari, Eric Vanden-Eijnden, Adithya Vijaykumar, Kirill Zinovjev
No abstract text is available yet for this article.
December 8, 2016: Faraday Discussions
https://www.readbyqxmd.com/read/27928822/-solanum-tuberosum-zpr1-encodes-a-light-regulated-nuclear-dna-binding-protein-adjusting-the-circadian-expression-of-stbbx24-to-light-cycle
#5
Agnieszka Kiełbowicz-Matuk, Jagoda Czarnecka, Ewa Banachowicz, Pascal Rey, Tadeusz Rorat
ZPR1 proteins belong to the C4-type of zinc finger coordinators known in animal cells to interact with other proteins and participate in cell growth and proliferation. In contrast, the current knowledge regarding plant ZPR1 proteins is very scarce. Here, we identify a novel potato nuclear factor belonging to this family and named StZPR1. StZPR1 is specifically expressed in photosynthetic organs during the light period and the ZPR1 protein is located in the nuclear chromatin fraction. Based on modeling and experimental analyses, we reveal the StZPR1 ability to bind the circadian DNA cis motif 'CAACAGCATC', named CIRC and present in the promoter of the clock-controlled double B-box StBBX24 gene, the expression of which peaks in the middle of the day...
December 8, 2016: Plant, Cell & Environment
https://www.readbyqxmd.com/read/27927170/erratum-to-in-vitro-and-in-vivo-activity-of-mir-92a-locked-nucleic-acid-lna-inhibitor-against-endometrial-cancer
#6
Anna Torres, Joanna Kozak, Agnieszka Korolczuk, Paulina Wdowiak, Ewa Domańska-Glonek, Ryszard Maciejewski, Kamil Torres
No abstract text is available yet for this article.
December 7, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27926809/public-health-physicians-and-dentists-in-poland-results-from-public-health-workforce-pilot-study
#7
Dorota Cianciara, Katarzyna Lewtak, Maria Piotrowicz, Małgorzata Gajewska, Ewa Urban, Katarzyna Brukało
Background: Monitoring public health workforce is one of the essential functions of the public health system. Objective: The aim of the study was to identify the specialities for physicians and dentists related to public health in the years 1951-2013, and analyse of available data on physicians and dentists certified as public health specialists (PHS) in 2003-2015. Material and Methods: The historical analysis covers a relevant regulations of a minister in charge of health...
2016: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/27925705/occurrence-of-pesticide-residues-in-fruiting-vegetables-from-production-farms-in-south-eastern-region-of-poland
#8
Magdalena Słowik-Borowiec, Ewa Szpyrka, Julian Rupar, Magdalena Podbielska, Aneta Matyaszek
Background: Considering the fact that pesticides are commonly used in agriculture, continuous monitoring of these substances in food products is of great significance. Residues of these substances can be present in crops after harvest. Objective: The aim of this study was to evaluate presence of pesticide residues in fruiting vegetables from production farms in south-eastern region of Poland in 2012–2015. Material and methods: 138 samples were tested using accredited test methods...
2016: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/27924059/an-open-label-phase-ii-study-evaluating-first-line-egfr-tyrosine-kinase-inhibitor-erlotinib-in-non-small-cell-lung-cancer-patients-with-tumors-showing-high-egfr-gene-copy-number
#9
Ewa Szutowicz-Zielińska, Krzysztof Konopa, Anna Kowalczyk, Małgorzata Suszko-Każarnowicz, Renata Duchnowska, Aleksandra Szczęsna, Magdalena Ratajska, Aleksander Sowa, Janusz Limon, Wojciech Biernat, Tomasz Burzykowski, Jacek Jassem, Rafał Dziadziuszko
BACKGROUND: First-line treatment with epidermal growth factor receptor (EGFR) inhibitors in NSCLC is effective in patients with activating EGFR mutations. The activity of erlotinib in patients harboring high EGFR gene copy number has been considered debatable. PATIENTS AND METHODS: A multicenter, open-label, single-arm phase II clinical trial was performed to test the efficacy of erlotinib in the first-line treatment of NSCLC patients harboring high EGFR gene copy number defined as ≥4 copies in ≥40% of cells...
December 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27923986/defense-responses-in-aspen-with-altered-pectin-methylesterase-activity-reveal-the-hormonal-inducers-of-tyloses
#10
Joanna Leśniewska, David Öhman, Magdalena Krzesłowska, Sunita Kushwah, Maria Barciszewska-Pacak, Leszek Kleczkowski, Bjorn Sundberg, Thomas Moritz, Ewa J Mellerowicz
Tyloses are ingrowths of parenchyma cells into the lumen of embolized xylem vessels, thereby protecting the remaining xylem from pathogens. They are found in heartwood, sapwood and in abscission zones, and can be induced by various stresses, but their molecular triggers are unknown. Here we report that down-regulation of PECTIN METHYLESTERASE 1 (PtxtPME1) in aspen triggers the formation of tyloses and activation of oxidative stress. We tested whether any of the oxidative-stress related hormones could induce tyloses in intact plantlets grown in sterile culture...
December 6, 2016: Plant Physiology
https://www.readbyqxmd.com/read/27918965/saponaria-officinalis-l-extract-surface-active-properties-and-impact-on-environmental-bacterial-strains
#11
Wojciech Smułek, Agata Zdarta, Amanda Pacholak, Agnieszka Zgoła-Grześkowiak, Łukasz Marczak, Maciej Jarzębski, Ewa Kaczorek
Plant-derived surfactants are characterised by low toxicity, high biodegradability and environmental compatibility. They therefore have many applications; for instance, they can be used in bioremediation to accelerate biodegradation processes, especially of hydrophobic pollutants. This paper analyses the properties of an extract from Saponaria officinalis L. containing saponins and its impact on bacterial strains isolated from soil, as well as its potential for application in hydrocarbon bioremediation. The tested extract from Saponaria officinalis L...
November 27, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27917126/perspectives-for-the-use-of-social-media-in-e-pharmamarketing
#12
Magdalena Syrkiewicz-Świtała, Piotr Romaniuk, Ewa Ptak
The Internet has become a common and global medium. It contains vast information resources and a wide range of communication instruments. One of the communication channels are social media, which increasingly are also used in the business field. Social media combined with mobile technology introduced new challenges to marketing activity. This trend is also observed on specific and highly regulated drug market. The aim of this article is to describe the perspectives for the use of social media in e-pharmamarketing...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27917012/enhanced-photocatalytic-electrochemical-and-photoelectrochemical-properties-of-tio2-nanotubes-arrays-modified-with-cu-agcu-and-bi-nanoparticles-obtained-via-radiolytic-reduction
#13
Michał Nischk, Paweł Mazierski, Zhishun Wei, Katarzyna Siuzdak, Natalie Amoin Kouame, Ewa Kowalska, Hynd Remita, Adriana Zaleska-Medynska
TiO2 nanotubes arrays (NTs), obtained via electrochemical anodization of Ti foil, were modified with monometallic (Cu, Bi) and bimetallic (AgCu) nanoparticles. Different amounts of metals' precursors were deposited on the surface of NTs by the spin-coating technique, and the reduction of metals was performed via gamma radiolysis. Surface modification of titania was studied by EDS and XPS analysis. The results show that AgCu nanoparticles exist in a Agcore-Cushell form. Photocatalytic activity was examined under UV irradiation and phenol was used as a model pollutant of water...
November 30, 2016: Applied Surface Science
https://www.readbyqxmd.com/read/27914767/smad-4-gene-expression-in-human-colorectal-cancer-comparison-with-some-clinical-and-pathological-parameters
#14
Agnieszka Wosiak, Damian Wodziński, Marcin Kolasa, Aleksandra Sałagacka-Kubiak, Ewa Balcerczak
The aim of this study was to evaluate the expression of SMAD-4 gene in cases of colorectal cancer and to link the obtained data with the development of this disease. SMAD-4 gene is responsible for the control of many important cellular processes, for example prevention of excessive epithelial cell growth and divisions. This suppressor gene is located on chromosome 18 within the region with frequent genetic losses in colorectal cancer. Inactivation of this gene is commonly found in pancreatic cancer where the SMAD-4 gene lost in the expression has been associated with a poor prognosis in this cancer...
October 26, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27914035/mobilization-of-peripheral-blood-stem-cells-and-changes-in-the-concentration-of-plasma-factors-influencing-their-movement-in-patients-with-panic-disorder
#15
Marcin Jabłoński, Jolanta Kucharska Mazur, Maciej Tarnowski, Barbara Dołęgowska, Daniel Pędziwiatr, Ewa Kubiś, Marta Budkowska, Daria Sałata, Justyna Pełka Wysiecka, Arkadiusz Kazimierczak, Artur Reginia, Mariusz Z Ratajczak, Jerzy Samochowiec
In this paper we examined whether stem cells and factors responsible for their movement may serve as new biological markers of anxiety disorders. The study was carried out on a group of 30 patients diagnosed with panic disorder (examined before and after treatment), compared to 30 healthy individuals forming the control group. We examined the number of circulating HSCs (hematopoetic stem cells) (Lin-/CD45 +/CD34 +) and HSCs (Lin-/CD45 +/AC133 +), the number of circulating VSELs (very small embryonic-like stem cells) (Lin-/CD45-/CD34 +) and VSELs (Lin-/CD45-/AC133 +), as well as the concentration of complement components: C3a, C5a and C5b-9, SDF-1 (stromal derived factor) and S1P (sphingosine-1-phosphate)...
December 2, 2016: Stem Cell Reviews
https://www.readbyqxmd.com/read/27913959/reaction-of-complement-factors-and-proteasomes-in-experimental-encephalitis
#16
Stefan Lange, Tomas Bergström, Ewa Johansson, Merna Oshalim, Ivar Lönnroth
Herpes simplex virus type 1 (HSV-1) encephalitis causes a deleterious inflammation and elevated intracranial pressure. As a step towards examining the origin of the inflammation, we here report the response of circulating proteasomes and complement factors in blood and cerebrospinal fluid (CSF) in rats infected with HSV-1. Infection was via the nasal route, with 1.1 × 10(4) plaque-forming units of HSV-1 strain 2762 given in one or both nostrils. A sandwich enzyme-linked immunosorbent assay was used to study the level of 26S proteasomes and their complex formation with complement factors 3 and 4...
December 2, 2016: Journal of Neurovirology
https://www.readbyqxmd.com/read/27913363/detecting-breathing-and-snoring-episodes-using-a-wireless-tracheal-sensor-a-feasibility-study
#17
Marcel Mlynczak, Ewa Migacz, Maciej Migacz, Wojciech Kukwa
OBJECTIVE: Sleep-disordered breathing is both a clinical and a social problem. This implies the need for convenient solutions to simplify screening and diagnosis. The aim of the study was to investigate the sensitivity and specificity of a novel wireless system in detecting breathing and snoring episodes during sleep. METHODS: A wireless acoustic sensor was elaborated and implemented. Segmentation (based on spectral thresholding and heuristics) and classification of all breathing episodes during recording were implemented through a mobile application...
November 29, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/27910808/magnesium-and-depression
#18
Anna Serefko, Aleksandra Szopa, Ewa Poleszak
Magnesium is one of the most important elements in the human body and is involved in a number of biochemical processes crucial for the proper functioning of the cardiovascular, alimentary, endocrine, and osteoarticular systems. It also plays a vital modulatory role in brain biochemistry, influencing several neurotransmission pathways associated with the development of depression. Personality changes, including apathy, depression, agitation, confusion, anxiety, and delirium are observed when there is a deficiency of this element...
March 1, 2016: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/27910300/a-new-missense-mutation-p-arg719leu-of-the-beta-myosin-heavy-chain-gene-in-a-patient-with-familial-hypertrophic-cardiomyopathy
#19
Monika Gawor, Zofia T Bilińska, Maria Franaszczyk, Ewa Michalak, Płoski Rafał, Jacek Grzybowski
No abstract text is available yet for this article.
February 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/27909437/differentially-methylated-dna-regions-in-monozygotic-twin-pairs-discordant-for-rheumatoid-arthritis-an-epigenome-wide-study
#20
Anders J Svendsen, Kristina Gervin, Robert Lyle, Lene Christiansen, Kirsten Kyvik, Peter Junker, Christian Nielsen, Gunnar Houen, Qihua Tan
OBJECTIVES: In an explorative epigenome-wide association study (EWAS) to search for gene independent, differentially methylated DNA positions and regions (DMRs) associated with rheumatoid arthritis (RA) by studying monozygotic (MZ) twin pairs discordant for RA. METHODS: Genomic DNA was isolated from whole blood samples from 28 MZ twin pairs discordant for RA. DNA methylation was measured using the HumanMethylation450 BeadChips. Smoking, anti-cyclic citrullinated peptide antibodies, and immunosuppressive treatment were included as covariates...
2016: Frontiers in Immunology
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