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A Tikvica Luetic, D Habek, M Stanojevic, D Miric Tesanic, R Padovan-Stern
A fetal epidural hematoma is a rare finding during the prenatal period, with different etiologies such as maternal trauma, infections, or maternal use of specific medications such as warfarin. Both ultrasonography and magnetic resonance imaging (MRI) have been used successfully to evaluate the fetal central nervous system. Although these methods are also useful in detecting and evaluating a fetal epidural hematoma, brain function of the neonate cannot be exactly predicted on the basis of the prenatal findings...
August 19, 2016: Zeitschrift Für Geburtshilfe und Neonatologie
Antoanela Čarija, Neira Puizina-Ivić, Dubravka Vuković, Lina Mirić Kovačević, Vesna Čapkun
BACKGROUND AND OBJECTIVE: To compare a single treatment of PDL-PDT with PDT for BCCs in terms of efficacy, aesthetic outcome, and pain in patients with multiple BCCs. STUDY DESIGN/MATERIALS AND METHODS: A prospective, controlled, intra-individual, investigator-blinded study was conducted on 15 patients with 62 BCCs. The BCCs on an individual patient were divided into two similarly-sized groups, and treated with PDT (630nm LED light source, fluence rate=30mW/cm(2), total dose of 150J/cm(2)) and 585 nm-PDL-PDT (spot size=7mm, fluence=10J/cm(2), pulse duration=10ms, 10% overlap, three passes, and cooling)...
August 8, 2016: Photodiagnosis and Photodynamic Therapy
Kara S Tanaka, Nina Lightdale-Miric
➤The prohibitive cost of cutting-edge prostheses prevents many children with a limb difference from obtaining them; however, new developments in 3-dimensional (3D) printing have the potential to increase the accessibility, customization, and procurement of such devices.➤Children with upper limb differences are ideal candidates for currently available 3D-printed devices because they quickly damage and outgrow prostheses, and the low cost of 3D printing makes repairs and upgrades substantially more affordable...
August 3, 2016: Journal of Bone and Joint Surgery. American Volume
Mirjana Miric, Sinisa Ristic, Bojan N Joksimovic, Snezana Medenica, Maja Racic, Slavica Ristic, Vedrana R Joksimovic, Mirjana Skipina
BACKGROUND: Benzodiazepines have a direct bronchodilatory effect. Methacholine is a non-selective muscarinic receptor agonist causing bronchoconstriction. AIM: To examine the effects of inhaled benzodiazepines, modulating bronchoconstriction induced by methacholine in patients with asthma. PATIENTS AND METHODS: Twelve patients with well controlled asthma were studied. On the first day, after determining the initial values of pulmonary function, a dose response curve was carried out with progressive doses of methacholine...
April 2016: Revista Médica de Chile
B Mikic, A Jotic, D Miric, M Nikolic, N Jankovic, N Arsovic
INTRODUCTION: Incidence of children with autism spectrum disorder (ASD) is rising through the years with estimated 1 in 68 in the US in 2014. This incidence is also rising in the population of congenitally deaf children. Favorable outcome after early cochlear implantation is expected due to plasticity and reorganization capacity of brain in infants and toddlers, but outcomes could be significantly modified in children with diagnosed ASD. Current methods of screening for autism have difficulties in establishing diagnosis in children who have both autism and other developmental delays, especially at such an early age...
June 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
S Sinoy, S M Fayaz, K D Charles, V K Suvanish, Josef P Kapfhammer, G K Rajanikant
MicroRNAs (miRNAs) are a group of small non-coding RNAs that regulate numerous signaling pathways involved in cerebral ischemia reperfusion injury. Recent finding demonstrated that miR-497 promotes ischemic neuronal death by negatively regulating anti-apoptotic proteins and therefore serves as a promising therapeutic target for cerebral ischemic injury. In this study, we present a systematic computational approach that includes 3D modeling, docking-based virtual screening, and molecular dynamics simulation to identify small-molecule inhibitors of pre-miR-497 maturation...
May 21, 2016: Molecular Neurobiology
Holly B Leshikar, Andrea S Bauer, Nina Lightdale-Miric, Fred Molitor, Peter M Waters
BACKGROUND: Brachial plexus birth palsy (BPBP) and clavicle fractures occur concurrently as well as in isolation during difficult deliveries. The concept that concurrent clavicle fracture may spare nerve injury has been advocated. Our aim was to compare those children with BPBP presenting to a tertiary care center with and without concurrent clavicle fractures and assess the utility of the presence of a clavicle fracture as a predictor of injury severity in children with BPBP. METHODS: Records of all patients belonging to a large prospective multicenter cohort study of infants with BPBP (Treatment and Outcomes of Brachial Plexus Injuries study) were analyzed for demographic information and birth information including risk factors, comorbidity, presence of clavicle fracture, and injury severity...
April 30, 2016: Journal of Pediatric Orthopedics
Bojana Kisic, Dijana Miric, Ilija Dragojevic, Julijana Rasic, Ljiljana Popovic
Chronic kidney disease (CKD) is a worldwide public health problem. Patients with CKD have a number of disorders in the organism, and the presence of oxidative stress and systemic inflammation in these patients is the subject of numerous studies. Chronic inflammation joined with oxidative stress contributes to the development of numerous complications: accelerated atherosclerosis process and cardiovascular disease, emergence of Type 2 diabetes mellitus, development of malnutrition, anaemia, hyperparathyroidism, and so forth, affecting the prognosis and quality of life of patients with CKD...
2016: Oxidative Medicine and Cellular Longevity
Sanja Ostojić, Sanja Djoković, Marina Radić-šestić, Mina Nikolić, Branka Mikić, Danica Mirić
BACKGROUND/AIM: Over the last 10 years more than 300 persons received cochlear implant in Serbia and more than 90% of the recipients were children under 10 years of age. The program of cochlear implantation includes postoperative rehabilitation in which cognitive, integrative and developmental methods are used. The study was conducted to reveal factors affecting communication performance (CP) of cochlear implanted (Cl) children. Special attention was focused on the influence of the duration and intensity of rehabilitation and hearing age on further development of communication skills...
August 2015: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Maria C S Inacio, Jennifer M Weiss, Alex Miric, Jessica J Hunt, Gary L Zohman, Elizabeth W Paxton
Cases of hip fracture recorded from 1/2009 to 12/2011 were ascertained using the Kaiser Permanente Hip Fracture Registry. The registry collects information on patient, procedure, surgeon, facility, and surgical outcomes. The population (N = 12,562) was predominantly white, women, and older (≥ 75 years), and 32% had at least 5 comorbidities. The average length of follow-up was 1.1 years. Hemiarthroplasty was the most common procedure (33.1%). Most fractures were treated by medium-volume surgeons at high-volume facilities...
2015: Permanente Journal
Deirdre D Ryan, Nina R Lightdale-Miric, Elizabeth R A Joiner, Tishya A L Wren, Lindsey Spragg, Michael J Heffernan, Robert M Kay, David L Skaggs
BACKGROUND: The anterior humeral line (AHL) is considered a valuable radiographic tool in the assessment of pediatric elbow sagittal plane alignment following injury. However, few studies exist that examine the validity of the AHL. The purpose of this study is to report the variability of the AHL in skeletally immature children with normal elbows. METHODS: A total of 124 true lateral elbow radiographs of normal pediatric elbows were retrospectively identified and examined for the relationship of the AHL to the capitellum...
March 2016: Journal of Pediatric Orthopedics
Nina Lightdale-Miric, Nicole M Mueske, Emily L Lawrence, Jennifer Loiselle, Jamie Berggren, Sudarshan Dayanidhi, Milan Stevanovic, Francisco J Valero-Cuevas, Tishya A L Wren
STUDY DESIGN: Retrospective Cohort INTRODUCTION: Important outcomes of polliciation to treat thumb hypoplasia/aplasia include strength, function, dexterity, and quality of life. PURPOSE OF THE STUDY: To evaluate outcomes and examine predictors of outcome after early childhood pollicization. METHODS: 8 children (10 hands) were evaluated 3-15 years after surgery. Physical examination, questionnaires, grip and pinch strength, Box and Blocks, 9-hole pegboard, and strength-dexterity (S-D) tests were performed...
April 2015: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
Alexander Miric, Maria C S Inacio, Matthew P Kelly, Robert S Namba
A greater number of patients aged 90 and over will become candidates for total hip arthroplasty (THA) as the nonagenarian population continues to grow. This study evaluated the patient characteristics and incidence of postoperative morbidity and mortality of 183 nonagenarian THA patients among 43,543 primary THA patients followed by a total joint replacement registry. Nonagenarians had a greater number of comorbidities preoperatively, experienced a higher one year mortality and had a longer hospital length of stay...
August 2015: Journal of Arthroplasty
Ljiljana M Popovic, Nebojsa R Mitic, Dijana Miric, Boban Bisevac, Mirjana Miric, Brankica Popovic
Exercise induces a multitude of physiological and biochemical changes in blood affecting its redox status. Tissue damage resulting from exercise induces activation of inflammatory cells followed by the increased activity of myeloperoxidase (MPO) in circulation. Vitamin C readily scavenges free radicals and may thereby prevent oxidative damage of important biological macromolecules. The aim of this study was to examine the effect of vitamin C supplementation on oxidative stress and neutrophil inflammatory response induced by acute and regular exercise...
2015: Oxidative Medicine and Cellular Longevity
D Miric Tesanic, D Habek, M Stanojevic, R Padovan-Štern
No abstract text is available yet for this article.
October 2015: Ultraschall in der Medizin
Nina Lightdale-Miric, Stephanie Iantorno, Erin Meisel
We present a case of primary tendon grafting in a 14-month-old infant for an index finger flexor digitorum profundus tendon laceration sustained during cesarean section with excellent functional results at 2-year follow-up.
December 2014: Journal of Hand Surgery
Slavica Ristić, Mirjana Mirić, Sladjana Jović, Sinisa Ristić, Jasmina Karić
BACKGROUND/AIM: The cell line C6 is a continuous cell line of rat glioma and, as a transplantable line, is frequently used for induction into in vivo model of primary brain tumor. It is believed that, pursuant to its histological traits and biological behavior, this experimental tumor corresponds to human anaplastic astrocytoma of grade II/III, which is characterized by proliferative and invasive potency, and marked cell differentiation. The aim of this study was to determine macroscopic analysis of rat brain with implanted tumor during tumorigenesis, histological features of tumor cells of induced brain tumor and markers of proliferation (proliferation cell nuclear antigen - PCNA, cytokeratin - CK 19) and differentiation (glial fibrillary acidic protein -GFAP) in rat brain with implanted tumor...
September 2014: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Nina Lightdale-Miric, Nicole M Mueske, Sudarshan Dayanidhi, Jennifer Loiselle, Jamie Berggren, Emily L Lawrence, Milan Stevanovic, Francisco J Valero-Cuevas, Tishya A L Wren
Dexterity after finger pollicization (reconstruction to thumb) is critical to functional outcomes. While most tests of hand function evaluate a combination of strength, coordination, and motor control, the Strength-Dexterity (S-D) paradigm focuses on the dynamic control of fingertip forces. We evaluated 10 pollicized and 5 non-pollicized hands from 8 participants ages 4-17 years (2 female, 6 male; 10.6 ± 4.5 years). Participants partially compressed and held an instrumented spring prone to buckling between the thumb and first finger to quantify dynamic control over the direction and magnitude of fingertip forces...
January 2015: Gait & Posture
Rade Grbic, Dijana J Miric, Bojana Kisic, Ljiljana Popovic, Vojkan Nestorovic, Aleksandar Vasic
In bacterial bone infections, excessively formed oxidants may result in local and systemic oxidative stress. Vitamin C is the major extracellular nonenzymatic antioxidant, also implicated in bone cells metabolism and viability. The physiological functions of vitamin C largely depend on its redox status. We sequentially assessed oxidative stress markers, hydroperoxides and malondialdehyde (MDA), total antioxidant activity (AOA), total vitamin C, ascorbic acid (Asc), and oxidized/reduced vitamin C ratio in 137 patients with acute osteomyelitis (OM)...
2014: Mediators of Inflammation
Christopher Lee, Nina Lightdale-Miric, Emory Chang, Robert Kay
UNLABELLED: Compartment syndrome does not always present classically in the pediatric population, making clinical diagnosis uniquely challenging. The purpose of this study was to identify signs and symptoms of compartment syndrome that may help risk-stratify pediatric patients upon presentation, as well as to report outcomes of 'silent' compartment syndrome in children. A retrospective review of cases of 'silent' compartment syndrome at a level I pediatric trauma center between 2000 and 2010 was conducted...
September 2014: Journal of Pediatric Orthopedics. Part B
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