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Goel, M

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https://www.readbyqxmd.com/read/28714975/association-analyses-based-on-false-discovery-rate-implicate-new-loci-for-coronary-artery-disease
#1
Christopher P Nelson, Anuj Goel, Adam S Butterworth, Stavroula Kanoni, Tom R Webb, Eirini Marouli, Lingyao Zeng, Ioanna Ntalla, Florence Y Lai, Jemma C Hopewell, Olga Giannakopoulou, Tao Jiang, Stephen E Hamby, Emanuele Di Angelantonio, Themistocles L Assimes, Erwin P Bottinger, John C Chambers, Robert Clarke, Colin N A Palmer, Richard M Cubbon, Patrick Ellinor, Raili Ermel, Evangelos Evangelou, Paul W Franks, Christopher Grace, Dongfeng Gu, Aroon D Hingorani, Joanna M M Howson, Erik Ingelsson, Adnan Kastrati, Thorsten Kessler, Theodosios Kyriakou, Terho Lehtimäki, Xiangfeng Lu, Yingchang Lu, Winfried März, Ruth McPherson, Andres Metspalu, Mar Pujades-Rodriguez, Arno Ruusalepp, Eric E Schadt, Amand F Schmidt, Michael J Sweeting, Pierre A Zalloua, Kamal AlGhalayini, Bernard D Keavney, Jaspal S Kooner, Ruth J F Loos, Riyaz S Patel, Martin K Rutter, Maciej Tomaszewski, Ioanna Tzoulaki, Eleftheria Zeggini, Jeanette Erdmann, George Dedoussis, Johan L M Björkegren, Heribert Schunkert, Martin Farrall, John Danesh, Nilesh J Samani, Hugh Watkins, Panos Deloukas
Genome-wide association studies (GWAS) in coronary artery disease (CAD) had identified 66 loci at 'genome-wide significance' (P < 5 × 10(-8)) at the time of this analysis, but a much larger number of putative loci at a false discovery rate (FDR) of 5% (refs. 1,2,3,4). Here we leverage an interim release of UK Biobank (UKBB) data to evaluate the validity of the FDR approach. We tested a CAD phenotype inclusive of angina (SOFT; ncases = 10,801) as well as a stricter definition without angina (HARD; ncases = 6,482) and selected cases with the former phenotype to conduct a meta-analysis using the two most recent CAD GWAS...
July 17, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28681760/department-of-neurosurgery-seth-gordhandas-sunderdas-medical-college-and-king-edward-vii-memorial-k-e-m-hospital-mumbai
#2
Sunil Pandya, Atul Goel
Seth Gordhandas Sunderdas Medical College and King Edward VII Memorial (K.E.M.) Hospital, Mumbai were inaugurated in 1925. This article traces its illustrious history and of the eminent neurosurgeons who shaped its destiny.
July 2017: Neurology India
https://www.readbyqxmd.com/read/28676292/intestinal-permeability-biomarker-zonulin-is-elevated-in-healthy-aging
#3
YanFei Qi, Ruby Goel, Seungbum Kim, Elaine M Richards, Christy S Carter, Carl J Pepine, Mohan K Raizada, Thomas W Buford
INTRODUCTION: Increased gut permeability ("leaky gut") has been proposed as a potential contributor to age-related inflammation and gut dysbiosis. However, information on the relationship between a leaky gut and inflammation and physical frailty during aging are limited. OBJECTIVE: To investigate the hypothesis that an aging-associated leaky gut is linked to the age-related inflammation and frailty. METHODS: Two cohorts of healthy adults were studied: young (18-30 years old, n = 19) and older (≥70 years old, n = 18)...
July 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28667359/sensitivity-of-susceptibility-weighted-imaging-in-detecting-developmental-venous-anomalies-and-associated-cavernomas-and-microhemorrhages-in-children
#4
Allen Young, Andrea Poretti, Thangamadhan Bosemani, Reema Goel, Thierry A G M Huisman
PURPOSE: Developmental venous anomalies (DVA) are common neuroimaging abnormalities that are traditionally diagnosed by contrast-enhanced T1-weighted images as the gold standard. We aimed to evaluate the sensitivity of SWI in detecting DVA and associated cavernous malformations (CM) and microhemorrhages in children in order to determine if SWI may replace contrast-enhanced MRI sequences. METHODS: Contrast-enhanced T1-weighted images were used as diagnostic gold standard for DVA...
June 30, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28664365/comparative-in-situ-biodegradation-studies-of-polyhydroxybutyrate-film-composites
#5
Prasenjit Debbarma, Shikha Raghuwanshi, Jyoti Singh, Deep Chandra Suyal, M G H Zaidi, Reeta Goel
Application of polyhydroxybutyrate (PHB) to plastic industry has expanded over the last decades due to its attracting features over petro-based plastic, and therefore, its waste accumulation in nature is inevitable. In the present study, a total of four bacterial strains, viz., MK3, PN12, PW1, and Lna3, were formulated into a consortium and subsequently used as biological tool for degradation of biopolymers. The consortium was tested through λ max shifts under in vitro conditions for utilization of PHB as sole carbon source...
July 2017: 3 Biotech
https://www.readbyqxmd.com/read/28649808/development-of-a-real-time-loop-mediated-isothermal-amplification-assay-for-detection-of-burkholderia-mallei
#6
V Pal, A Saxena, S Singh, A K Goel, J S Kumar, M M Parida, G P Rai
Burkholderia mallei is the aetiological agent of glanders, a highly contagious and re-emerging zoonotic disease. Early diagnosis of glanders is critically important to ensure timely treatment with appropriate antibiotics in humans, and to prevent spread of infection in animals. Molecular detection of B. mallei has always been troublesome because of its genetic similarity with Burkholderia pseudomallei, the causative agent of melioidosis. In present investigation, a set of six B. mallei-specific primers were designed and a simple, rapid, specific and sensitive real-time loop-mediated isothermal amplification (LAMP) assay was developed for detection of B...
June 25, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28648066/effects-of-topography-related-puff-parameters-on-carbonyl-delivery-in-mainstream-cigarette-smoke
#7
Samantha M Reilly, Reema Goel, Zachary Bitzer, Ryan J Elias, Jonathan Foulds, Joshua Muscat, John P Richie
Smoking topography parameters differ substantially between individual smokers and may lead to significant variation in tobacco smoke exposure and risk for tobacco-caused diseases. However, to date, little is known regarding the impact of individual puff parameters on the delivery of many harmful smoke constituents including carbonyls. To examine this, we determined the effect of altering individual puff parameters on mainstream smoke carbonyl levels in machine-smoked reference cigarettes. Carbonyls including formaldehyde, acetaldehyde, crotonaldehyde, propionaldehyde, methyl ethyl ketone (MEK), acrolein, and acetone were determined in cigarette smoke by HPLC after derivatization with 2,4-dinitrophenylhydrazine (DNPH)...
July 5, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28635248/safety-feasibility-tips-and-tricks-of-permanent-pacemaker-implantation-in-patients-with-isolated-persistent-left-superior-vena-cava
#8
Santosh K Sinha, Vinay Krishna, Ramesh Thakur, Ashutosh Kumar, Karandeep Singh, Mukesh J Jha, Mahamdulla Razi, Vikas Mishra, Mohammad Asif, Nasar Abdali, Dibbendhu Khanra, Amit Goel, Umeshwar Pandey, Chandra M Varma
No abstract text is available yet for this article.
August 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28619185/high-prevalence-of-restless-legs-syndrome-willis-ekbom-disease-rls-wed-among-people-living-at-high-altitude-in-the-indian-himalaya
#9
Ravi Gupta, Jan Ulfberg, Richard P Allen, Deepak Goel
BACKGROUND: At high altitude, prevalence of restless legs syndrome has been found to be greater than expected in small population-based studies, which did not use validated tools for identification of RLS. However, it is not known as to whether this increased prevalence is associated with altitude or increased risk factors for RLS in these populations or errors in identification of RLS. METHOD: This population based, door-to-door study was conducted at low altitude (400 m above sea level) and high altitudes (1900-2000 m and 3200 m above sea level) using random stratified sampling in Himalayan and sub-Himalayan region of India...
July 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28588888/thioguanine-in-inflammatory-bowel-disease-long-term-efficacy-and-safety
#10
Mark G Ward, Kamal V Patel, Viraj C Kariyawasam, Rishi Goel, Ben Warner, Tim R Elliott, Paul A Blaker, Peter M Irving, Anthony M Marinaki, Jeremy D Sanderson
BACKGROUND: Thioguanine (TG) is efficacious in inflammatory bowel disease (IBD), but its toxicity, particularly nodular regenerative hyperplasia (NRH) of the liver, has limited its use. We assessed the long-term clinical outcomes and safety of TG in patients whom were intolerant or refractory to conventional immunomodulators. METHODS: This is a retrospective, single-centre study of IBD patients treated with TG from 2001-2013. Response was defined as clinical remission (Harvey-Bradshaw Index < 5 for Crohn's disease (CD), Simple Clinical Colitis Activity Index < 4 for ulcerative colitis (UC)) without corticosteroids or, if receiving anti-tumour-necrosis-factor (anti-TNF) therapy, absence of dose escalation...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28549702/iagg-iagg-garn-international-survey-of-end-of-life-care-in-nursing-homes
#11
Cara L Wallace, Daniel Swagerty, Mario Barbagallo, Bruno Vellas, Heung Bong Cha, Iva Holmerova, Birong Dong, Raymond Koopmans, Alfonso J Cruz-Jentoft, Luis Miguel Gutierrez Robledo, Juan Cuadros Moreno, Ramzi Hajjar, Jean Woo, Hidenori Arai, Jiro Okochi, Renuka Visvanathan, Samia A Abdul-Rahman, Ashish Goel, Andrea Moser, Yves Rolland, Angela M Abbatecola, Marcello Russo, John E Morley
This article reports the findings of a survey on end-of-life (EOL) care in nursing homes of 18 long-term care experts across 15 countries. The experts were chosen as a convenience-based sample of known experts in each country. The survey was administered in 2016 and included both open-ended responses for defining hospice care, palliative care, and "end of life," and a series of questions related to the following areas-attitudes toward EOL care, current practice and EOL interventions, structure of care, and routine barriers...
June 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28542124/virologic-monitoring-of-poliovirus-type-2-after-oral-poliovirus-vaccine-type-2-withdrawal-in-april-2016-worldwide-2016-2017
#12
Ousmane M Diop, Humayun Asghar, Evgeniy Gavrilin, Nicksy Gumede Moeletsi, Gloria Rey Benito, Fem Paladin, Sirima Pattamadilok, Yan Zhang, Ajay Goel, Arshad Quddus
The Global Polio Eradication Initiative (GPEI) has made substantial progress since its launch in 1988; only 37 wild poliovirus type 1 (WPV1) cases were detected in 2016, the lowest annual count ever. Wild poliovirus type 3 has not been detected since November 2012, and wild poliovirus type 2 was officially declared eradicated in September 2015. This success is attributable to the wide use of live oral poliovirus vaccines (OPVs). Since 2001, numerous outbreaks were caused by the emergence of genetically divergent vaccine-derived polioviruses (VDPVs) whose genetic drift from the parental OPV strains indicates prolonged replication or circulation (1)...
May 26, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28535802/n-blr-a-primate-specific-non-coding-transcript-leads-to-colorectal-cancer-invasion-and-migration
#13
Isidore Rigoutsos, Sang Kil Lee, Su Youn Nam, Simone Anfossi, Barbara Pasculli, Martin Pichler, Yi Jing, Cristian Rodriguez-Aguayo, Aristeidis G Telonis, Simona Rossi, Cristina Ivan, Tina Catela Ivkovic, Linda Fabris, Peter M Clark, Hui Ling, Masayoshi Shimizu, Roxana S Redis, Maitri Y Shah, Xinna Zhang, Yoshinaga Okugawa, Eun Jung Jung, Aristotelis Tsirigos, Li Huang, Jana Ferdin, Roberta Gafà, Riccardo Spizzo, Milena S Nicoloso, Anurag N Paranjape, Maryam Shariati, Aida Tiron, Jen Jen Yeh, Raul Teruel-Montoya, Lianchun Xiao, Sonia A Melo, David Menter, Zhi-Qin Jiang, Elsa R Flores, Massimo Negrini, Ajay Goel, Menashe Bar-Eli, Sendurai A Mani, Chang Gong Liu, Gabriel Lopez-Berestein, Ioana Berindan-Neagoe, Manel Esteller, Scott Kopetz, Giovanni Lanza, George A Calin
BACKGROUND: Non-coding RNAs have been drawing increasing attention in recent years as functional data suggest that they play important roles in key cellular processes. N-BLR is a primate-specific long non-coding RNA that modulates the epithelial-to-mesenchymal transition, facilitates cell migration, and increases colorectal cancer invasion. RESULTS: We performed multivariate analyses of data from two independent cohorts of colorectal cancer patients and show that the abundance of N-BLR is associated with tumor stage, invasion potential, and overall patient survival...
May 24, 2017: Genome Biology
https://www.readbyqxmd.com/read/28528972/brand-variation-in-oxidant-production-in-mainstream-cigarette-smoke-carbonyls-and-free-radicals
#14
Samantha M Reilly, Reema Goel, Neil Trushin, Ryan J Elias, Jonathan Foulds, Joshua Muscat, Jason Liao, John P Richie
Oxidative stress/damage resulting from exposure to cigarette smoke plays a critical role in the development of tobacco-caused diseases. Carbonyls and free radicals are two major classes of oxidants in tobacco smoke. There is little information on the combined delivery of these oxidants across different cigarette brands; thus, we set out to measure and compare their levels in mainstream smoke from popular US cigarettes. Mainstream smoke from 28 different cigarette brands produced by smoking (FTC protocol) was analyzed for five important, abundant carbonyls, and levels were compared to previously determined free radical for the same brands...
May 18, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28506538/epitope-specific-immunotherapy-targeting-cd4-positive-t-cells-in-coeliac-disease-two-randomised-double-blind-placebo-controlled-phase-1-studies
#15
Gautam Goel, Tim King, A James Daveson, Jane M Andrews, Janakan Krishnarajah, Richard Krause, Gregor J E Brown, Ronald Fogel, Charles F Barish, Roger Epstein, Timothy P Kinney, Philip B Miner, Jason A Tye-Din, Adam Girardin, Juha Taavela, Alina Popp, John Sidney, Markku Mäki, Kaela E Goldstein, Patrick H Griffin, Suyue Wang, John L Dzuris, Leslie J Williams, Alessandro Sette, Ramnik J Xavier, Ludvig M Sollid, Bana Jabri, Robert P Anderson
BACKGROUND: A gluten-free diet is the only means to manage coeliac disease, a permanent immune intolerance to gluten. We developed a therapeutic vaccine, Nexvax2, designed to treat coeliac disease. Nexvax2 is an adjuvant-free mix of three peptides that include immunodominant epitopes for gluten-specific CD4-positive T cells. The vaccine is intended to engage and render gluten-specific CD4-positive T cells unresponsive to further antigenic stimulation. We assessed the safety and pharmacodynamics of the vaccine in patients with coeliac disease on a gluten-free diet...
May 11, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28501948/corneal-tomography-and-biomechanics-in-primary-pterygium
#16
M Vanathi, Sahil Goel, Anita Ganger, Tushar Agarwal, T Dada, Sudarshan Khokhar
PURPOSE: To study the Scheimpflug's imaging and corneal biomechanics in primary pterygium. METHODS: A prospective observational study of 55 patients with unilateral primary nasal pterygium was done. The normal fellow eyes of patients with pterygium were taken as controls. Clinical parameters noted included visual acuity, values of corneal curvature by doing Scheimpflug imaging, wavefront aberrations in terms of higher and lower-order aberrations and corneal hysteresis (CH) as well as corneal resistance factor (CRF) values by using ocular response analyzer...
May 13, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28485336/efficacy-and-toxicity-of-cetuximab-with-chemotherapy-in-recurrent-and-metastatic-head-and-neck-cancer-a-prospective-observational-study
#17
S Tiwari, V Goel, M C John, N Patnaik, D C Doval
BACKGROUND: In squamous cell carcinoma of the head and neck (SCCHN), epidermal growth factor receptor is expressed at very high levels. Hence, we have done this study to assess the response and tolerability of cetuximab and platinum-based chemotherapy in recurrent and metastatic (R/M) head and neck squamous cell cancer (HNSCC) in view of paucity of data from the Indian subcontinent. MATERIALS AND METHODS: In this prospective study, patients of R/M SCCHN were randomly enrolled from September 2012 to April 2015...
October 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28480076/treatment-of-advanced-gall-bladder-cancer-in-the-real-world-can-continuation-chemotherapy-improve-outcomes
#18
Vikas Ostwal, Rakesh Pinninti, Anant Ramaswamy, Nitin Shetty, Mahesh Goel, Shraddha Patkar, Jimmy Mirani, Chaitali Nashikkar, Shripad Banavali
BACKGROUND: Gemcitabine-Platinum doublet chemotherapy is the standard of care in patients with locally advanced inoperable and metastatic (LA/M) Gall bladder cancers (GBC). METHODS: Consecutive patients with LA/M GBC treated with Gemcitabine-Cisplatin (GC) or Gemcitabine-Oxaliplatin (GO) as first line palliative chemotherapy from January 2013 to June 2015 were retrospectively analysed. Patients who were able to continue chemotherapy beyond 6-8 cycles were separately compared to those who were potential candidates for this approach, but chose not to continue chemotherapy...
April 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28472018/does-spanning-a-lateral-lumbar-interbody-cage-across-the-vertebral-ring-apophysis-increase-loads-required-for-failure-and-mitigate-endplate-violation
#19
David C Briski, Vijay K Goel, Bradford S Waddell, Hassan Serhan, Manoj K Kodigudla, Vivek Palepu, Anand K Agarwal, Joseph M Zavatsky
STUDY DESIGN: Randomized Biomechanical Cadaveric Study - Level II. OBJECTIVE: We aimed to elucidate that placing lateral lumbar interbody cages that span the stronger ring apophysis will require increasing loads for failure, decreasing rates of subsidence, regardless of bone density or endplate integrity. SUMMARY OF BACKGROUND DATA: There are several reports regarding the rates and grades of cage subsidence when utilizing the lateral lumbar interbody fusion technique...
May 2, 2017: Spine
https://www.readbyqxmd.com/read/28461624/loss-of-cardioprotective-effects-at-the-adamts7-locus-as-a-result-of-gene-smoking-interactions
#20
Danish Saleheen, Wei Zhao, Robin Young, Christopher P Nelson, WeangKee Ho, Jane F Ferguson, Asif Rasheed, Kristy Ou, Sylvia T Nurnberg, Robert C Bauer, Anuj Goel, Ron Do, Alexandre F R Stewart, Jaana Hartiala, Weihua Zhang, Gudmar Thorleifsson, Rona J Strawbridge, Juha Sinisalo, Stavroula Kanoni, Sanaz Sedaghat, Eirini Marouli, Kati Kristiansson, Jing Hua Zhao, Robert Scott, Dominique Gauguier, Svati H Shah, Albert Vernon Smith, Natalie van Zuydam, Amanda J Cox, Christina Willenborg, Thorsten Kessler, Lingyao Zeng, Michael A Province, Andrea Ganna, Lars Lind, Nancy L Pedersen, Charles C White, Anni Joensuu, Marcus Edi Kleber, Alistair S Hall, Winfried März, Veikko Salomaa, Christopher O'Donnell, Erik Ingelsson, Mary F Feitosa, Jeanette Erdmann, Donald W Bowden, Colin N A Palmer, Vilmundur Gudnason, Ulf De Faire, Pierre Zalloua, Nicholas Wareham, John R Thompson, Kari Kuulasmaa, George Dedoussis, Markus Perola, Abbas Dehghan, John C Chambers, Jaspal Kooner, Hooman Allayee, Panos Deloukas, Ruth McPherson, Kari Stefansson, Heribert Schunkert, Sekar Kathiresan, Martin Farrall, Philippe Marcel Frossard, Daniel J Rader, Nilesh J Samani, Muredach P Reilly
BACKGROUND: Common diseases such as coronary heart disease (CHD) are complex in etiology. The interaction of genetic susceptibility with lifestyle factors may play a prominent role. However, gene-lifestyle interactions for CHD have been difficult to identify. Here, we investigate interaction of smoking behavior, a potent lifestyle factor, with genotypes that have been shown to associate with CHD risk. METHODS: We analyzed data on 60 919 CHD cases and 80 243 controls from 29 studies for gene-smoking interactions for genetic variants at 45 loci previously reported to be associated with CHD risk...
June 13, 2017: Circulation
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