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Goel, M

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https://www.readbyqxmd.com/read/29430735/reassembly-of-89-zr-labeled-cancer-cell-membranes-into-multicompartment-membrane-derived-liposomes-for-pet-trackable-tumor-targeted-theranostics
#1
Bo Yu, Shreya Goel, Dalong Ni, Paul A Ellison, Cerise M Siamof, Dawei Jiang, Liang Cheng, Lei Kang, Faquan Yu, Zhuang Liu, Todd E Barnhart, Qianjun He, Han Zhang, Weibo Cai
Nanoengineering of cell membranes holds great potential to revolutionize tumor-targeted theranostics, owing to their innate biocompatibility and ability to escape from the immune and reticuloendothelial systems. However, tailoring and integrating cell membranes with drug and imaging agents into one versatile nanoparticle are still challenging. Here, multicompartment membrane-derived liposomes (MCLs) are developed by reassembling cancer cell membranes with Tween-80, and are used to conjugate 89 Zr via deferoxamine chelator and load tetrakis(4-carboxyphenyl) porphyrin for in vivo noninvasive quantitative tracing by positron emission tomography imaging and photodynamic therapy (PDT), respectively...
February 12, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29406797/sequelae-of-index-complications-following-inpatient-head-and-neck-surgery-characterizing-secondary-complications
#2
Alexander N Goel, Karam W Badran, Alexander M Garrett, Maie A St John, Jennifer L Long
Objective To characterize patterns of secondary complications after inpatient head and neck surgery. Study Design Retrospective cohort study. Setting National Surgical Quality Improvement Program (2005-2015). Subjects and Methods We identified 18,584 patients who underwent inpatient otolaryngologic surgery. Four index complications were studied: pneumonia, bleeding or transfusion event (BTE), deep/organ space surgical site infection (SSI), and myocardial infarction (MI). Each patient with an index complication was matched to a control patient based on propensity for the index event and event-free days...
February 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29396516/rap80-is-an-independent-prognosis-biomarker-for-the-outcome-of-patients-with-esophageal-squamous-cell-carcinoma
#3
Qingyuan Yang, Wanrun Lin, Zhiwei Liu, Jiabei Zhu, Nan Huang, Zhongqi Cui, Zeping Han, Qiuhui Pan, Ajay Goel, Fenyong Sun
Esophageal squamous cell carcinoma (ESCC) is the most popular pathology of esophageal cancer (EC) in China, especially in Henan province, mid-east of China. Presently, targeting DNA damage repair (DDR) factors is a promising approach for cancer therapy. Our group has been focusing on exploring the DDR factors overexpressed in ESCC tissues to provide potential targets for therapies for many years. RAP80/UIMC1 (ubiquitin interaction motif containing 1), one of those DDR factors we tested, was highly overexpressed in ESCC tissues compared with adjacent normal tissues...
February 2, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29332394/compositional-dependence-of-solubility-retention-of-molybdenum-oxides-in-aluminoborosilicate-based-model-nuclear-waste-glasses
#4
Antoine Brehault, Deepak Patil, Hrishikesh Kamat, Randall E Youngman, Lynn M Thirion, John C Mauro, Claire Corkhill, John Stuart McCloy, Ashutosh Goel
Molybdenum oxides are an integral component of the high-level waste streams being generated from the nuclear reactors in several countries. Although borosilicate glass has been chosen as the baseline waste form by most of the countries to immobilize these waste streams, molybdate oxyanions (MoO42-) exhibit very low solubility (~ 1 mol.%) in these glass matrices. In the past 3-4 decades, several studies describing the compositional and structural dependence of molybdate anions in borosilicate and aluminoborosilicate glasses have been reported in the literature, providing a basis for our understanding of fundamental science that governs the solubility and retention of these species in the nuclear waste glasses...
January 14, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29314289/long-term-outcomes-post-chronic-total-occlusion-intervention-implications-of-completeness-of-revascularization
#5
Pravin K Goel, Roopali Khanna, C M Pandey, Fauzia Ashfaq
BACKGROUND: Long term clinical outcomes post chronic total occlusion (CTO) intervention may depend not only on CTO success/failure alone but also on Completeness of revascularization. OBJECTIVES: To determine long term outcomes post CTO intervention and relate them to both success versus failure and Complete Revascularization (CR) versus Incomplete Revascularization (IR). METHODS: Consecutive patients taken up for CTO intervention with at-least one CTO vessel between Jan 2006 to Dec 2015 were included...
January 4, 2018: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29313447/the-feasibility-of-putrescible-components-of-municipal-solid-waste-for-biomethane-production-at-hyderabad-pakistan
#6
Korai M Safar, Mahar R Bux, Uqaili M Aslam, Bhattacharjee A Shankar, Ramesh K Goel
This study analyzes the feasibility of putrescible components of municipal solid waste (PCMSW) such as food waste (FW) and yard waste (YW) for methane production in Pakistan. The batch experiments have been conducted at two different inoculums to substrate ratios (ISRs) by using various inoculums under mesophilic condition. The highest methane yield of FW and YW is achieved to be 428 Nml g-1 volatile solids (VS) added and 304 Nml g-1 VS added respectively by using buffalo dung inoculum at ISR-5. While, lowest methane yield of FW and YW is obtained as 236 Nml g-1 VS added and 151Nml g-1 VS added respectively by using effluent from a continuous stirrer tank reactor as inoculum at ISR-3...
January 1, 2018: Waste Management & Research
https://www.readbyqxmd.com/read/29302519/are-our-subcenters-equipped-enough-to-provide-primary-health-care-to-the-community-a-study-to-explore-the-gaps-in-workforce-and-infrastructure-in-the-subcenters-from-north-india
#7
M A Bashar, Sonu Goel
Background: A Sub-Centre (SC) is most peripheral and first point of contact between the primary healthcare system and the community in the rural areas. The success of any nationwide program largely depends on well-functioning SCs providing services of acceptable standards to people. Indian Public Health Standards (IPHS) for SCs was prepared keeping in view the minimum standards required to provide quality and need sensitive health care to the community. Materials and Methods: A cross-sectional study was conducted in Ambala District of Haryana to assess the availability of physical infrastructure, manpower, drugs and equipment in the SCs...
April 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29202779/correlates-of-poor-mental-health-in-early-pregnancy-in-obese-european-women
#8
Matteo C Sattler, Judith G M Jelsma, Annick Bogaerts, David Simmons, Gernot Desoye, Rosa Corcoy, Juan M Adelantado, Alexandra Kautzky-Willer, Jürgen Harreiter, Frans A van Assche, Roland Devlieger, Goele Jans, Sander Galjaard, David Hill, Peter Damm, Elisabeth R Mathiesen, Ewa Wender-Ozegowska, Agnieszka Zawiejska, Kinga Blumska, Annunziata Lapolla, Maria G Dalfrà, Alessandra Bertolotto, Fidelma Dunne, Dorte M Jensen, Lise Lotte T Andersen, Frank J Snoek, Mireille N M van Poppel
BACKGROUND: Depression during pregnancy is associated with higher maternal morbidity and mortality, and subsequent possible adverse effects on the cognitive, emotional and behavioral development of the child. The aim of the study was to identify maternal characteristics associated with poor mental health, in a group of overweight/obese pregnant women in nine European countries, and thus, to contribute to better recognition and intervention for maternal depression. METHODS: In this cross-sectional observational study, baseline data from early pregnancy (< 20 weeks) of the DALI (Vitamin D and Lifestyle Intervention for gestational diabetes mellitus prevention) study were analyzed...
December 4, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29201462/efficacy-of-second-line-pemetrexed-carboplatin-in-egfr-activating-mutation-positive-nsclc-does-exon-19-deletion-differ-from-exon-21-mutation
#9
Amit Joshi, Vanita Noronha, Vijay M Patil, Anuradha Chougule, Atanu Bhattacharjee, Rajiv Kumar, Supriya Goud, Sucheta More, Anant Ramaswamy, Ashay Karpe, Nikhil Pande, Arun Chandrasekharan, Alok Goel, Vikas Talreja, Abhishek Mahajan, Amit Janu, Nilendu Purandare, Kumar Prabhash
Background: It is unknown whether the outcomes of second-line pemetrexed-carboplatin chemotherapy administered after progression on gefitinib are dependent on type of EGFR mutation present at baseline. Method: Adult non-small-cell lung cancer patients, with exon 19 deletion or exon 21 L858R mutation, who progressed on gefitinib and received pemetrexed-carboplatin chemotherapy were selected for this analysis. Result: 55 patients received pemetrexed-carboplatin as second-line treatment...
2017: Chemotherapy Research and Practice
https://www.readbyqxmd.com/read/29199663/robotic-resections-in-hepatobiliary-oncology-initial-experience-with-xi-da-vinci-system-in-india
#10
M Chandarana, S Patkar, A Tamhankar, S Garg, M Bhandare, M Goel
INTRODUCTION: Minimal invasive surgery has proven its advantages over open surgeries in the perioperative period. Food and Drug Administration approved da Vinci robot in 2000. The latest version, da Vinci Xi system has a mobile tower-based robot with several modifications to improve the functionality, versatility, and operative ease. None of the centers have reported exclusively on hepatobiliary oncology using the da Vinci Xi system. We report our initial experience. AIMS AND OBJECTIVES: To study the feasibility, advantages, and discuss the operative technique of da Vinci Xi system in hepatobiliary oncology...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29198293/comparison-of-subjective-sleep-quality-of-long-term-residents-at-low-and-high-altitudes-saraha-study
#11
Ravi Gupta, Jan Ulfberg, Richard P Allen, Deepak Goel
STUDY OBJECTIVES: To study the effect of altitude on subjective sleep quality in populations living at high and low altitudes after excluding cases of restless legs syndrome (RLS). METHODS: This population-based study was conducted at three different altitudes (400 m, 1,900-2,000 m, and 3,200 m above sea level). All consenting subjects available from random stratified sampling in the Himalayan and sub-Himalayan regions of India were included in the study (ages 18 to 84 years)...
November 29, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29193156/validating-and-implementing-the-use-of-an-infusion-pump-for-the-administration-of-thawed-hematopoietic-progenitor-cells-a-single-institution-experience
#12
Ronit Reich-Slotky, Melissa M Cushing, Yen-Michael S Hsu, Michael Ancharski, Johanna M Rojas, Lara M Scrimenti, Shawna Robilio, Dianna Assalone, Therese Roselli, Danielle Guarneri, Ljiljana V Vasovic, Ruchika Goel, Tsiporah Shore, Koen van Besien
BACKGROUND: Direct thaw and administration of previously cryopreserved peripheral blood stem cell products is a commonly used practice and should be performed rapidly to reduce cellular damage caused by dimethyl sulfoxide exposure. Cells are typically thawed at the bedside and infused by gravity through a high-flow-rate central venous catheter. An existing nontunneled catheter is occasionally used instead and often results in a slower infusion rate. To ensure expedient and consistent infusions, we validated and implemented the use of an infusion pump for thawed peripheral blood stem cells...
November 29, 2017: Transfusion
https://www.readbyqxmd.com/read/29184169/nmnat1-variants-cause-cone-and-cone-rod-dystrophy
#13
Benjamin M Nash, Richard Symes, Himanshu Goel, Marcel E Dinger, Bruce Bennetts, John R Grigg, Robyn V Jamieson
Cone and cone-rod dystrophies (CD and CRD, respectively) are degenerative retinal diseases that predominantly affect the cone photoreceptors. The underlying disease gene is not known in approximately 75% of autosomal recessive cases. Variants in NMNAT1 cause a severe, early-onset retinal dystrophy called Leber congenital amaurosis (LCA). We report two patients where clinical phenotyping indicated diagnoses of CD and CRD, respectively. NMNAT1 variants were identified, with Case 1 showing an extremely rare homozygous variant c...
November 28, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29178789/chelator-free-labeling-of-metal-oxide-nanostructures-with-zirconium-89-for-positron-emission-tomography-imaging
#14
Liang Cheng, Sida Shen, Dawei Jiang, Qiutong Jin, Paul A Ellison, Emily B Ehlerding, Shreya Goel, Guosheng Song, Peng Huang, Todd E Barnhart, Zhuang Liu, Weibo Cai
Radiolabeling of molecules or nanoparticles to form imaging probes is critical for positron emission tomography (PET) imaging, which, with high sensitivity and the ability for quantitative imaging, has been widely used in the clinic. While conventional radiolabeling often employs chelator molecules, a general method for chelator-free radiolabeling of a wide range of materials remains to be developed. Herein, we uncovered that ten different types of metal oxide (MxOy, M=Gd, Ti, Te, Eu, Ta, Er, Y, Yb, Ce, or Mo, x=1-2, y=2-5) nanomaterials with polyethylene glycol (PEG) modification could be labeled with 89Zr, a PET tracer, via a simple yet general chelator-free radiolabeling method upon simple mixing...
November 27, 2017: ACS Nano
https://www.readbyqxmd.com/read/29166613/niche-cadherins-control-the-quiescence-to-activation-transition-in-muscle-stem-cells
#15
Aviva J Goel, Marysia-Kolbe Rieder, Hans-Henning Arnold, Glenn L Radice, Robert S Krauss
Many adult stem cells display prolonged quiescence, promoted by cues from their niche. Upon tissue damage, a coordinated transition to the activated state is required because non-physiological breaks in quiescence often lead to stem cell depletion and impaired regeneration. Here, we identify cadherin-mediated adhesion and signaling between muscle stem cells (satellite cells [SCs]) and their myofiber niche as a mechanism that orchestrates the quiescence-to-activation transition. Conditional removal of N-cadherin and M-cadherin in mice leads to a break in SC quiescence, with long-term expansion of a regeneration-proficient SC pool...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29161504/solvent-and-temperature-effects-on-free-radical-formation-in-electronic-cigarette-aerosols
#16
Zachary T Bitzer, Reema Goel, Samantha M Reilly, Jonathan Foulds, Joshua Muscat, Ryan J Elias, John P Richie
The ever-evolving market of electronic cigarettes (e-cigarettes) presents a challenge for analyzing and characterizing the harmful products they can produce. Earlier we reported that e-cigarette aerosols can deliver high levels of reactive free radicals; however, there is little data characterizing the production of these potentially harmful oxidants. Thus, we have performed a detailed analysis of the different parameters affecting free radical production from e-cigarettes. Using a temperature controlled e-cigarette device and novel mechanism for reliably simulating e-cigarette usage conditions including coil activation and puff flow, we analyzed the effects of temperature, wattage, and e-liquid solvent composition of propylene glycol (PG) and glycerol (GLY) on radical production...
November 21, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29127067/understanding-the-structural-drivers-governing-glass-water-interactions-in-borosilicate-based-model-bioactive-glasses
#17
Nicholas Stone-Weiss, Eric M Pierce, Randall E Youngman, Ozgur Gulbiten, Nicholas J Smith, Jincheng Du, Ashutosh Goel
The past decade has witnessed a significant upsurge in the development of borate and borosilicate based resorbable bioactive glasses owing to their faster degradation rate in comparison to their silicate counterparts. However, due to our lack of understanding about the fundamental science governing the aqueous corrosion of these glasses, most of the borate/borosilicate based bioactive glasses reported in the literature have been designed by "trial-and-error" approach. With an ever-increasing demand for their application in treating a broad spectrum of non-skeletal health problems, it is becoming increasingly difficult to design advanced glass formulations using the same conventional approach...
November 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29104613/impact-of-exon-19-versus-exon-21-egfr-activating-mutation-on-outcomes-with-upfront-pemetrexed-carboplatin-chemotherapy
#18
Vanita Noronha, Vijay Patil, Amit Joshi, Anuradha Chougule, Atanu Bhattacharjee, Rajiv Kumar, Sucheta More, Supriya Goud, Ashay Karpe, Anant Ramaswamy, Nikhil Pande, Arun Chandrasekharan, Alok Goel, Vikas Talreja, Abhishek Mahajan, Amit Janu, Nilendu Purandare, Kumar Prabhash
Background: EGFR mutation subtype is a recognised factor impacting outcomes of patients receiving oral tyrosine kinase inhibitors (TKIs) in non-small-cell lung cancer (NSCLC). Evidence for the effect of this factor on outcomes in patients receiving pemetrexed is limited. Methods: We completed a study comparing pemetrexed-platinum combination versus oral TKI in EGFR mutation-positive patients in lung cancer. We analysed the impact of EGFR mutation subtype, specifically, exon 19 and 21 on the PFS and OS of patients treated with pemetrexed (500 mg/m(2) on day 1) and carboplatin (AUC 5 on day 1) as first-line therapy...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29101463/a-drug-drug-interaction-study-to-assess-the-effect-of-the-cyp1a2-inhibitor-fluvoxamine-on-the-pharmacokinetics-of-dovitinib-tki258-in-patients-with-advanced-solid-tumors
#19
Vincent A de Weger, Sanjay Goel, Roger von Moos, Jan H M Schellens, Nicholas Mach, Eugene Tan, Suraj Anand, Jeffrey W Scott, Ulrik Lassen
PURPOSE: Dovitinib is an orally available multi tyrosine kinase inhibitor which inhibits VEGFR 1-3, FGFR 1-3, and PDGFR. This study was performed to investigate the potential drug-drug interaction of dovitinib with the CYP1A2 inhibitor fluvoxamine in patients with advanced solid tumors. METHODS: Non-smoking patients of ≥ 18 years with advanced solid tumors, excluding breast cancer, were included. Patients were treated with a dose of 300 mg in 5 days on/2 days off schedule...
November 3, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29070841/an-apiap2-member-regulates-expression-of-clonally-variant-genes-of-the-human-malaria-parasite-plasmodium-falciparum
#20
Rafael M Martins, Cameron R Macpherson, Aurélie Claes, Christine Scheidig-Benatar, Hiroshi Sakamoto, Xue Yan Yam, Peter Preiser, Suchi Goel, Mats Wahlgren, Odile Sismeiro, Jean-Yves Coppée, Artur Scherf
Variegated surface antigen expression is key to chronic infection and pathogenesis of the human malaria parasite Plasmodium falciparum. This protozoan parasite expresses distinct surface molecules that are encoded by clonally variant gene families such as var, rif and stevor. The molecular mechanisms governing activation of individual members remain ill-defined. To investigate the molecular events of the initial transcriptional activation process we focused on a member of the apicomplexan ApiAP2 transcription factor family predicted to bind to the 5' upstream regions of the var gene family, AP2-exp (PF3D7_1466400)...
October 25, 2017: Scientific Reports
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