keyword
MENU ▼
Read by QxMD icon Read
search

Goel, M

keyword
https://www.readbyqxmd.com/read/29202779/correlates-of-poor-mental-health-in-early-pregnancy-in-obese-european-women
#1
Matteo C Sattler, Judith G M Jelsma, Annick Bogaerts, David Simmons, Gernot Desoye, Rosa Corcoy, Juan M Adelantado, Alexandra Kautzky-Willer, Jürgen Harreiter, Frans A van Assche, Roland Devlieger, Goele Jans, Sander Galjaard, David Hill, Peter Damm, Elisabeth R Mathiesen, Ewa Wender-Ozegowska, Agnieszka Zawiejska, Kinga Blumska, Annunziata Lapolla, Maria G Dalfrà, Alessandra Bertolotto, Fidelma Dunne, Dorte M Jensen, Lise Lotte T Andersen, Frank J Snoek, Mireille N M van Poppel
BACKGROUND: Depression during pregnancy is associated with higher maternal morbidity and mortality, and subsequent possible adverse effects on the cognitive, emotional and behavioral development of the child. The aim of the study was to identify maternal characteristics associated with poor mental health, in a group of overweight/obese pregnant women in nine European countries, and thus, to contribute to better recognition and intervention for maternal depression. METHODS: In this cross-sectional observational study, baseline data from early pregnancy (< 20 weeks) of the DALI (Vitamin D and Lifestyle Intervention for gestational diabetes mellitus prevention) study were analyzed...
December 4, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29201462/efficacy-of-second-line-pemetrexed-carboplatin-in-egfr-activating-mutation-positive-nsclc-does-exon-19-deletion-differ-from-exon-21-mutation
#2
Amit Joshi, Vanita Noronha, Vijay M Patil, Anuradha Chougule, Atanu Bhattacharjee, Rajiv Kumar, Supriya Goud, Sucheta More, Anant Ramaswamy, Ashay Karpe, Nikhil Pande, Arun Chandrasekharan, Alok Goel, Vikas Talreja, Abhishek Mahajan, Amit Janu, Nilendu Purandare, Kumar Prabhash
Background: It is unknown whether the outcomes of second-line pemetrexed-carboplatin chemotherapy administered after progression on gefitinib are dependent on type of EGFR mutation present at baseline. Method: Adult non-small-cell lung cancer patients, with exon 19 deletion or exon 21 L858R mutation, who progressed on gefitinib and received pemetrexed-carboplatin chemotherapy were selected for this analysis. Result: 55 patients received pemetrexed-carboplatin as second-line treatment...
2017: Chemotherapy Research and Practice
https://www.readbyqxmd.com/read/29199663/robotic-resections-in-hepatobiliary-oncology-initial-experience-with-xi-da-vinci-system-in-india
#3
M Chandarana, S Patkar, A Tamhankar, S Garg, M Bhandare, M Goel
INTRODUCTION: Minimal invasive surgery has proven its advantages over open surgeries in the perioperative period. Food and Drug Administration approved da Vinci robot in 2000. The latest version, da Vinci Xi system has a mobile tower-based robot with several modifications to improve the functionality, versatility, and operative ease. None of the centers have reported exclusively on hepatobiliary oncology using the da Vinci Xi system. We report our initial experience. AIMS AND OBJECTIVES: To study the feasibility, advantages, and discuss the operative technique of da Vinci Xi system in hepatobiliary oncology...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29198293/comparison-of-subjective-sleep-quality-of-long-term-residents-at-low-and-high-altitudes-saraha-study
#4
Ravi Gupta, Jan Ulfberg, Richard P Allen, Deepak Goel
STUDY OBJECTIVES: To study the effect of altitude on subjective sleep quality in populations living at high and low altitudes after excluding cases of restless legs syndrome (RLS). METHODS: This population-based study was conducted at three different altitudes (400 m, 1,900-2,000 m, and 3,200 m above sea level). All consenting subjects available from random stratified sampling in the Himalayan and sub-Himalayan regions of India were included in the study (ages 18 to 84 years)...
November 29, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29193156/validating-and-implementing-the-use-of-an-infusion-pump-for-the-administration-of-thawed-hematopoietic-progenitor-cells-a-single-institution-experience
#5
Ronit Reich-Slotky, Melissa M Cushing, Yen-Michael S Hsu, Michael Ancharski, Johanna M Rojas, Lara M Scrimenti, Shawna Robilio, Dianna Assalone, Therese Roselli, Danielle Guarneri, Ljiljana V Vasovic, Ruchika Goel, Tsiporah Shore, Koen van Besien
BACKGROUND: Direct thaw and administration of previously cryopreserved peripheral blood stem cell products is a commonly used practice and should be performed rapidly to reduce cellular damage caused by dimethyl sulfoxide exposure. Cells are typically thawed at the bedside and infused by gravity through a high-flow-rate central venous catheter. An existing nontunneled catheter is occasionally used instead and often results in a slower infusion rate. To ensure expedient and consistent infusions, we validated and implemented the use of an infusion pump for thawed peripheral blood stem cells...
November 29, 2017: Transfusion
https://www.readbyqxmd.com/read/29184169/nmnat1-variants-cause-cone-and-cone-rod-dystrophy
#6
Benjamin M Nash, Richard Symes, Himanshu Goel, Marcel E Dinger, Bruce Bennetts, John R Grigg, Robyn V Jamieson
Cone and cone-rod dystrophies (CD and CRD, respectively) are degenerative retinal diseases that predominantly affect the cone photoreceptors. The underlying disease gene is not known in approximately 75% of autosomal recessive cases. Variants in NMNAT1 cause a severe, early-onset retinal dystrophy called Leber congenital amaurosis (LCA). We report two patients where clinical phenotyping indicated diagnoses of CD and CRD, respectively. NMNAT1 variants were identified, with Case 1 showing an extremely rare homozygous variant c...
November 28, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29178789/chelator-free-labeling-of-metal-oxide-nanostructures-with-zirconium-89-for-positron-emission-tomography-imaging
#7
Liang Cheng, Sida Shen, Dawei Jiang, Qiutong Jin, Paul A Ellison, Emily B Ehlerding, Shreya Goel, Guosheng Song, Peng Huang, Todd E Barnhart, Zhuang Liu, Weibo Cai
Radiolabeling of molecules or nanoparticles to form imaging probes is critical for positron emission tomography (PET) imaging, which, with high sensitivity and the ability for quantitative imaging, has been widely used in the clinic. While conventional radiolabeling often employs chelator molecules, a general method for chelator-free radiolabeling of a wide range of materials remains to be developed. Herein, we uncovered that ten different types of metal oxide (MxOy, M=Gd, Ti, Te, Eu, Ta, Er, Y, Yb, Ce, or Mo, x=1-2, y=2-5) nanomaterials with polyethylene glycol (PEG) modification could be labeled with 89Zr, a PET tracer, via a simple yet general chelator-free radiolabeling method upon simple mixing...
November 27, 2017: ACS Nano
https://www.readbyqxmd.com/read/29166613/niche-cadherins-control-the-quiescence-to-activation-transition-in-muscle-stem-cells
#8
Aviva J Goel, Marysia-Kolbe Rieder, Hans-Henning Arnold, Glenn L Radice, Robert S Krauss
Many adult stem cells display prolonged quiescence, promoted by cues from their niche. Upon tissue damage, a coordinated transition to the activated state is required because non-physiological breaks in quiescence often lead to stem cell depletion and impaired regeneration. Here, we identify cadherin-mediated adhesion and signaling between muscle stem cells (satellite cells [SCs]) and their myofiber niche as a mechanism that orchestrates the quiescence-to-activation transition. Conditional removal of N-cadherin and M-cadherin in mice leads to a break in SC quiescence, with long-term expansion of a regeneration-proficient SC pool...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29161504/solvent-and-temperature-effects-on-free-radical-formation-in-electronic-cigarette-aerosols
#9
Zachary T Bitzer, Reema Goel, Samantha M Reilly, Jonathan Foulds, Joshua Muscat, Ryan J Elias, John P Richie
The ever-evolving market of electronic cigarettes (e-cigarettes) presents a challenge for analyzing and characterizing the harmful products they can produce. Earlier we reported that e-cigarette aerosols can deliver high levels of reactive free radicals; however, there is little data characterizing the production of these potentially harmful oxidants. Thus, we have performed a detailed analysis of the different parameters affecting free radical production from e-cigarettes. Using a temperature controlled e-cigarette device and novel mechanism for reliably simulating e-cigarette usage conditions including coil activation and puff flow, we analyzed the effects of temperature, wattage, and e-liquid solvent composition of propylene glycol (PG) and glycerol (GLY) on radical production...
November 21, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29127067/understanding-the-structural-drivers-governing-glass-water-interactions-in-borosilicate-based-model-bioactive-glasses
#10
Nicholas Stone-Weiss, Eric M Pierce, Randall E Youngman, Ozgur Gulbiten, Nicholas J Smith, Jincheng Du, Ashutosh Goel
The past decade has witnessed a significant upsurge in the development of borate and borosilicate based resorbable bioactive glasses owing to their faster degradation rate in comparison to their silicate counterparts. However, due to our lack of understanding about the fundamental science governing the aqueous corrosion of these glasses, most of the borate/borosilicate based bioactive glasses reported in the literature have been designed by "trial-and-error" approach. With an ever-increasing demand for their application in treating a broad spectrum of non-skeletal health problems, it is becoming increasingly difficult to design advanced glass formulations using the same conventional approach...
November 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29104613/impact-of-exon-19-versus-exon-21-egfr-activating-mutation-on-outcomes-with-upfront-pemetrexed-carboplatin-chemotherapy
#11
Vanita Noronha, Vijay Patil, Amit Joshi, Anuradha Chougule, Atanu Bhattacharjee, Rajiv Kumar, Sucheta More, Supriya Goud, Ashay Karpe, Anant Ramaswamy, Nikhil Pande, Arun Chandrasekharan, Alok Goel, Vikas Talreja, Abhishek Mahajan, Amit Janu, Nilendu Purandare, Kumar Prabhash
Background: EGFR mutation subtype is a recognised factor impacting outcomes of patients receiving oral tyrosine kinase inhibitors (TKIs) in non-small-cell lung cancer (NSCLC). Evidence for the effect of this factor on outcomes in patients receiving pemetrexed is limited. Methods: We completed a study comparing pemetrexed-platinum combination versus oral TKI in EGFR mutation-positive patients in lung cancer. We analysed the impact of EGFR mutation subtype, specifically, exon 19 and 21 on the PFS and OS of patients treated with pemetrexed (500 mg/m(2) on day 1) and carboplatin (AUC 5 on day 1) as first-line therapy...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29101463/a-drug-drug-interaction-study-to-assess-the-effect-of-the-cyp1a2-inhibitor-fluvoxamine-on-the-pharmacokinetics-of-dovitinib-tki258-in-patients-with-advanced-solid-tumors
#12
Vincent A de Weger, Sanjay Goel, Roger von Moos, Jan H M Schellens, Nicholas Mach, Eugene Tan, Suraj Anand, Jeffrey W Scott, Ulrik Lassen
PURPOSE: Dovitinib is an orally available multi tyrosine kinase inhibitor which inhibits VEGFR 1-3, FGFR 1-3, and PDGFR. This study was performed to investigate the potential drug-drug interaction of dovitinib with the CYP1A2 inhibitor fluvoxamine in patients with advanced solid tumors. METHODS: Non-smoking patients of ≥ 18 years with advanced solid tumors, excluding breast cancer, were included. Patients were treated with a dose of 300 mg in 5 days on/2 days off schedule...
November 3, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29070841/an-apiap2-member-regulates-expression-of-clonally-variant-genes-of-the-human-malaria-parasite-plasmodium-falciparum
#13
Rafael M Martins, Cameron R Macpherson, Aurélie Claes, Christine Scheidig-Benatar, Hiroshi Sakamoto, Xue Yan Yam, Peter Preiser, Suchi Goel, Mats Wahlgren, Odile Sismeiro, Jean-Yves Coppée, Artur Scherf
Variegated surface antigen expression is key to chronic infection and pathogenesis of the human malaria parasite Plasmodium falciparum. This protozoan parasite expresses distinct surface molecules that are encoded by clonally variant gene families such as var, rif and stevor. The molecular mechanisms governing activation of individual members remain ill-defined. To investigate the molecular events of the initial transcriptional activation process we focused on a member of the apicomplexan ApiAP2 transcription factor family predicted to bind to the 5' upstream regions of the var gene family, AP2-exp (PF3D7_1466400)...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29063567/best-paper-selection
#14
(no author information available yet)
Agarwal V, Podchiyska T, Banda JM, Goel V, Leung TI, Minty EP, Sweeney TE, Gyang E, Shah NH. Learning statistical models of phenotypes using noisy labeled training data. J Am Med Inform Assoc 2016;23(6):1166-73 https://academic.oup.com/jamia/article-lookup/doi/10.1093/jamia/ocw028 Harmanci A, Gerstein M. Quantification of private information leakage from phenotype-genotype data: linking attacks. Nat Methods 2016;13(3):251-6 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834871/ Pfiffner PB, Pinyol I, Natter MD, Mandl KD...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29060446/design-and-development-of-a-customizable-telemedicine-platform-for-improving-access-to-healthcare-for-underserved-populations
#15
Neha A Goel, Amal A Alam, Emily M R Eggert, Soumyadipta Acharya
Telemedicine offers a method to bridge the healthcare access gap in low and middle income countries (LMICs) by connecting providers with patients using appropriate technology. Here we describe the design and development of a novel modular telemedicine platform, Intelehealth, that would enable health systems to connect remote doctors with patients in rural clinics using a customizable Android-based platform and a cloud-based electronic health record system at the backend (OpenMRS). This open source platform enables task shifting of medically relevant information gathering by a local health worker, transmission of this information to a remote doctor, and a telephonic conversation between the doctor and the patient that subsequently allows for delivery of an appropriate therapeutic plan...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29059441/a-survey-of-nicotine-yields-in-small-cigar-smoke-influence-of-cigar-design-and-smoking-regimens
#16
Reema Goel, Neil Trushin, Samantha M Reilly, Zachary Bitzer, Joshua Muscat, Jonathan Foulds, John P Richie
Introduction: While the popularity of small cigar brands that resemble cigarettes, including both little cigars (LC) and filtered cigars (FC), has been on the rise, little is known about the delivery of nicotine from these products. Our objective was to determine the nicotine yields of small cigars in comparison to cigarettes. Methods: Nicotine yields from LC, FC and 3R4F and 1R6F research cigarettes were determined from mainstream smoke generated on a smoking machine under the International Organization of Standardization (ISO) and Canadian Intense (CI) methods...
September 27, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29040868/identification-of-a-novel-proinsulin-associated-snp-and-demonstration-that-proinsulin-is-unlikely-to-be-a-causal-factor-in-subclinical-vascular-remodelling-using-mendelian-randomisation
#17
Rona J Strawbridge, Angela Silveira, Marcel den Hoed, Stefan Gustafsson, Jian'an Luan, Denis Rybin, Josée Dupuis, Ruifang Li-Gao, Maryam Kavousi, Abbas Dehghan, Kadri Haljas, Jari Lahti, Jesper R Gådin, Alexandra Bäcklund, Ulf de Faire, Karl Gertow, Phillipe Giral, Anuj Goel, Steve E Humphries, Sudhir Kurl, Claudia Langenberg, Lars L Lannfelt, Lars Lind, Cecilia C M Lindgren, Elmo Mannarino, Dennis O Mook-Kanamori, Andrew P Morris, Renée de Mutsert, Rainer Rauramaa, Peter Saliba-Gustafsson, Bengt Sennblad, Andries J Smit, Ann-Christine Syvänen, Elena Tremoli, Fabrizio Veglia, Björn Zethelius, Hanna M Björck, Johan G Eriksson, Albert Hofman, Oscar H Franco, Hugh Watkins, J Wouter Jukema, Jose C Florez, Nicholas J Wareham, James B Meigs, Erik Ingelsson, Damiano Baldassarre, Anders Hamsten
BACKGROUND AND AIMS: Increased proinsulin relative to insulin levels have been associated with subclinical atherosclerosis (measured by carotid intima-media thickness (cIMT)) and are predictive of future cardiovascular disease (CVD), independently of established risk factors. The mechanisms linking proinsulin to atherosclerosis and CVD are unclear. A genome-wide meta-analysis has identified nine loci associated with circulating proinsulin levels. Using proinsulin-associated SNPs, we set out to use a Mendelian randomisation approach to test the hypothesis that proinsulin plays a causal role in subclinical vascular remodelling...
November 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29037523/a-systematic-review-of-measurement-properties-of-patient-reported-outcome-measures-in-psoriatic-arthritis-a-grappa-omeract-initiative
#18
REVIEW
Pil Højgaard, Louise Klokker, Ana-Maria Orbai, Kim Holmsted, Else M Bartels, Ying Ying Leung, Niti Goel, Maarten de Wit, Dafna D Gladman, Philip Mease, Lene Dreyer, Lars E Kristensen, Oliver FitzGerald, William Tillett, Laure Gossec, Philip Helliwell, Vibeke Strand, Alexis Ogdie, Caroline B Terwee, Robin Christensen
BACKGROUND: An updated psoriatic arthritis (PsA) core outcome set (COS) for randomized controlled trials (RCTs) was endorsed at the Outcome Measures in Rheumatology (OMERACT) meeting in 2016. OBJECTIVES: To synthesize the evidence on measurement properties of patient reported outcome measures (PROMs) for PsA and thereby contribute to development of a PsA core outcome measurement set (COMS) as described by the OMERACT Filter 2.0. METHODS: A systematic literature search was performed in EMBASE, MEDLINE and PsycINFO on Jan 1, 2017 to identify full-text articles with an aim of assessing the measurement properties of PROMs in PsA...
September 9, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29024426/c-reactive-protein-gene-polymorphisms-rs1205-in-asian-indian-patients-with-takayasu-arteritis-associations-and-phenotype-correlations
#19
Aswin M Nair, Ruchika Goel, Mohan Hindhumati, Krati Shah, Puneet Chandana, Visalakshi Jayaseelan, Kabeerdoss Jayakanthan, George Joseph, Sumita Danda, Debashish Danda
BACKGROUND/PURPOSE: Normal C-reactive protein (CRP) in active Takayasu arteritis (TA) is a dilemma. We attempted to validate our pilot study finding of rs1205 in CRP gene being protective against TA. METHODS: Genomic DNA of 104 patients and 185 sex-matched healthy controls were genotyped for rs1205 by Taqman assay. Clinical details, demography, angiographic and activity scores (Indian Takayasu arteritis score 2010) were recorded prospectively at baseline and during follow-up visits for 12 months...
October 11, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29021270/benefits-of-cardiac-rehabilitation-on-cardiovascular-outcomes-in-patients-with-diabetes-mellitus-after-percutaneous-coronary-intervention
#20
Manuel F Jiménez-Navarro, Francisco Lopez-Jimenez, Luis M Pérez-Belmonte, Ryan J Lennon, Carlos Diaz-Melean, J P Rodriguez-Escudero, Kashish Goel, Daniel Crusan, Abhiram Prasad, Ray W Squires, Randal J Thomas
BACKGROUND: Participation in cardiac rehabilitation (CR) is an essential component of care for patients with coronary artery disease. However, little is known about its benefit on cardiovascular outcomes in patients with diabetes mellitus (DM) who have undergone percutaneous coronary intervention. The aim of our study was to evaluate the impact of CR in this high-risk group of patients. METHODS AND RESULTS: We performed a retrospective analysis of all patients with DM who underwent percutaneous coronary intervention in Olmsted County (Minnesota) between 1994 and 2010, assessing the impact of CR participation on clinical outcomes...
October 11, 2017: Journal of the American Heart Association
keyword
keyword
10341
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"