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Goel, M

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https://www.readbyqxmd.com/read/28542124/virologic-monitoring-of-poliovirus-type-2-after-oral-poliovirus-vaccine-type-2-withdrawal-in-april-2016-worldwide-2016-2017
#1
Ousmane M Diop, Humayun Asghar, Evgeniy Gavrilin, Nicksy Gumede Moeletsi, Gloria Rey Benito, Fem Paladin, Sirima Pattamadilok, Yan Zhang, Ajay Goel, Arshad Quddus
The Global Polio Eradication Initiative (GPEI) has made substantial progress since its launch in 1988; only 37 wild poliovirus type 1 (WPV1) cases were detected in 2016, the lowest annual count ever. Wild poliovirus type 3 has not been detected since November 2012, and wild poliovirus type 2 was officially declared eradicated in September 2015. This success is attributable to the wide use of live oral poliovirus vaccines (OPVs). Since 2001, numerous outbreaks were caused by the emergence of genetically divergent vaccine-derived polioviruses (VDPVs) whose genetic drift from the parental OPV strains indicates prolonged replication or circulation (1)...
May 26, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28535802/n-blr-a-primate-specific-non-coding-transcript-leads-to-colorectal-cancer-invasion-and-migration
#2
Isidore Rigoutsos, Sang Kil Lee, Su Youn Nam, Simone Anfossi, Barbara Pasculli, Martin Pichler, Yi Jing, Cristian Rodriguez-Aguayo, Aristeidis G Telonis, Simona Rossi, Cristina Ivan, Tina Catela Ivkovic, Linda Fabris, Peter M Clark, Hui Ling, Masayoshi Shimizu, Roxana S Redis, Maitri Y Shah, Xinna Zhang, Yoshinaga Okugawa, Eun Jung Jung, Aristotelis Tsirigos, Li Huang, Jana Ferdin, Roberta Gafà, Riccardo Spizzo, Milena S Nicoloso, Anurag N Paranjape, Maryam Shariati, Aida Tiron, Jen Jen Yeh, Raul Teruel-Montoya, Lianchun Xiao, Sonia A Melo, David Menter, Zhi-Qin Jiang, Elsa R Flores, Massimo Negrini, Ajay Goel, Menashe Bar-Eli, Sendurai A Mani, Chang Gong Liu, Gabriel Lopez-Berestein, Ioana Berindan-Neagoe, Manel Esteller, Scott Kopetz, Giovanni Lanza, George A Calin
BACKGROUND: Non-coding RNAs have been drawing increasing attention in recent years as functional data suggest that they play important roles in key cellular processes. N-BLR is a primate-specific long non-coding RNA that modulates the epithelial-to-mesenchymal transition, facilitates cell migration, and increases colorectal cancer invasion. RESULTS: We performed multivariate analyses of data from two independent cohorts of colorectal cancer patients and show that the abundance of N-BLR is associated with tumor stage, invasion potential, and overall patient survival...
May 24, 2017: Genome Biology
https://www.readbyqxmd.com/read/28528972/brand-variation-in-oxidant-production-in-mainstream-cigarette-smoke-carbonyls-and-free-radicals
#3
Samantha M Reilly, Reema Goel, Neil Trushin, Ryan J Elias, Jonathan Foulds, Joshua Muscat, Jason Liao, John P Richie
Oxidative stress/damage resulting from exposure to cigarette smoke plays a critical role in the development of tobacco-caused diseases. Carbonyls and free radicals are two major classes of oxidants in tobacco smoke. There is little information on the combined delivery of these oxidants across different cigarette brands; thus, we set out to measure and compare their levels in mainstream smoke from popular US cigarettes. Mainstream smoke from 28 different cigarette brands produced by smoking (FTC protocol) was analyzed for five important, abundant carbonyls, and levels were compared to previously determined free radical for the same brands...
May 18, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28506538/epitope-specific-immunotherapy-targeting-cd4-positive-t-cells-in-coeliac-disease-two-randomised-double-blind-placebo-controlled-phase-1-studies
#4
Gautam Goel, Tim King, A James Daveson, Jane M Andrews, Janakan Krishnarajah, Richard Krause, Gregor J E Brown, Ronald Fogel, Charles F Barish, Roger Epstein, Timothy P Kinney, Philip B Miner, Jason A Tye-Din, Adam Girardin, Juha Taavela, Alina Popp, John Sidney, Markku Mäki, Kaela E Goldstein, Patrick H Griffin, Suyue Wang, John L Dzuris, Leslie J Williams, Alessandro Sette, Ramnik J Xavier, Ludvig M Sollid, Bana Jabri, Robert P Anderson
BACKGROUND: A gluten-free diet is the only means to manage coeliac disease, a permanent immune intolerance to gluten. We developed a therapeutic vaccine, Nexvax2, designed to treat coeliac disease. Nexvax2 is an adjuvant-free mix of three peptides that include immunodominant epitopes for gluten-specific CD4-positive T cells. The vaccine is intended to engage and render gluten-specific CD4-positive T cells unresponsive to further antigenic stimulation. We assessed the safety and pharmacodynamics of the vaccine in patients with coeliac disease on a gluten-free diet...
May 11, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28501948/corneal-tomography-and-biomechanics-in-primary-pterygium
#5
M Vanathi, Sahil Goel, Anita Ganger, Tushar Agarwal, T Dada, Sudarshan Khokhar
PURPOSE: To study the Scheimpflug's imaging and corneal biomechanics in primary pterygium. METHODS: A prospective observational study of 55 patients with unilateral primary nasal pterygium was done. The normal fellow eyes of patients with pterygium were taken as controls. Clinical parameters noted included visual acuity, values of corneal curvature by doing Scheimpflug imaging, wavefront aberrations in terms of higher and lower-order aberrations and corneal hysteresis (CH) as well as corneal resistance factor (CRF) values by using ocular response analyzer...
May 13, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28485336/efficacy-and-toxicity-of-cetuximab-with-chemotherapy-in-recurrent-and-metastatic-head-and-neck-cancer-a-prospective-observational-study
#6
S Tiwari, V Goel, M C John, N Patnaik, D C Doval
BACKGROUND: In squamous cell carcinoma of the head and neck (SCCHN), epidermal growth factor receptor is expressed at very high levels. Hence, we have done this study to assess the response and tolerability of cetuximab and platinum-based chemotherapy in recurrent and metastatic (R/M) head and neck squamous cell cancer (HNSCC) in view of paucity of data from the Indian subcontinent. MATERIALS AND METHODS: In this prospective study, patients of R/M SCCHN were randomly enrolled from September 2012 to April 2015...
October 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28480076/treatment-of-advanced-gall-bladder-cancer-in-the-real-world-can-continuation-chemotherapy-improve-outcomes
#7
Vikas Ostwal, Rakesh Pinninti, Anant Ramaswamy, Nitin Shetty, Mahesh Goel, Shraddha Patkar, Jimmy Mirani, Chaitali Nashikkar, Shripad Banavali
BACKGROUND: Gemcitabine-Platinum doublet chemotherapy is the standard of care in patients with locally advanced inoperable and metastatic (LA/M) Gall bladder cancers (GBC). METHODS: Consecutive patients with LA/M GBC treated with Gemcitabine-Cisplatin (GC) or Gemcitabine-Oxaliplatin (GO) as first line palliative chemotherapy from January 2013 to June 2015 were retrospectively analysed. Patients who were able to continue chemotherapy beyond 6-8 cycles were separately compared to those who were potential candidates for this approach, but chose not to continue chemotherapy...
April 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28472018/does-spanning-a-lateral-lumbar-interbody-cage-across-the-vertebral-ring-apophysis-increase-loads-required-for-failure-and-mitigate-endplate-violation
#8
David C Briski, Vijay K Goel, Bradford S Waddell, Hassan Serhan, Manoj K Kodigudla, Vivek Palepu, Anand K Agarwal, Joseph M Zavatsky
STUDY DESIGN: Randomized Biomechanical Cadaveric Study - Level II. OBJECTIVE: We aimed to elucidate that placing lateral lumbar interbody cages that span the stronger ring apophysis will require increasing loads for failure, decreasing rates of subsidence, regardless of bone density or endplate integrity. SUMMARY OF BACKGROUND DATA: There are several reports regarding the rates and grades of cage subsidence when utilizing the lateral lumbar interbody fusion technique...
May 2, 2017: Spine
https://www.readbyqxmd.com/read/28461624/loss-of-cardio-protective-effects-at-the-adamts7-locus-due-to-gene-smoking-interactions
#9
Danish Saleheen, Wei Zhao, Robin Young, Christopher P Nelson, Weang Kee Ho, Jane F Ferguson, Asif Rasheed, Kristy Ou, Sylvia T Nurnberg, Robert C Bauer, Anuj Goel, Ron Do, Alexandre F R Stewart, Jaana Hartiala, Weihua Zhang, Gudmar Thorleifsson, Rona J Strawbridge, Juha Sinisalo, Stavroula Kanoni, Sanaz Sedaghat, Eirini Marouli, Kati Kristiansson, Jing Hua Zhao, Robert Scott, Dominique Gauguier, Svati H Shah, Albert Vernon Smith, Natalie Van Zuydam, Amanda J Cox, Christina Willenborg, Thorsten Kessler, Lingyao Zeng, Michael A Province, Andrea Ganna, Lars Lind, Nancy L Pedersen, Charles C White, Anni Joensuu, Marcus Edi Kleber, Alistair S Hall, Winfried März, Veikko Salomaa, Christopher O'Donnell, Erik Ingelsson, Mary F Feitosa, Jeanette Erdmann, Donald W Bowden, Colin N A Palmer, Vilmundur Gudnason, Ulf de Faire, Pierre Zalloua, Nicholas Wareham, John R Thompson, Kari Kuulasmaa, George Dedoussis, Markus Perola, Abbas Dehghan, John C Chambers, Jaspal Kooner, Hooman Allayee, Panos Deloukas, Ruth McPherson, Kari Stefansson, Heribert Schunkert, Sekar Kathiresan, Martin Farrall, Philippe M Frossard, Daniel J Rader, Nilesh Samani, Muredach P Reilly
Background -Common diseases such as coronary heart disease (CHD) are complex in etiology. The interaction of genetic susceptibility with lifestyle factors may play a prominent role. However, gene-environment interactions for CHD have been difficult to identify. Here, we investigate interaction of smoking behavior, a potent lifestyle factor, with genotypes that have been shown to associate with CHD risk. Methods -We analyzed data on 60,919 CHD cases and 80,243 controls from 29 studies for gene-smoking interactions for genetic variants at 45 loci previously reported to associate with CHD risk...
May 1, 2017: Circulation
https://www.readbyqxmd.com/read/28461522/proceedings-of-the-grappa-2016-retreat
#10
Deepak R Jadon, Dafna D Gladman, Philip J Mease, Oliver FitzGerald, Vinod Chandran, Niti Goel, Cheryl F Rosen, Walter P Maksymowych, Christopher T Ritchlin, Alexis Ogdie, Laura C Coates, Alberto Cauli, Enrique R Soriano, M Elaine Husni, Willemina Campbell, Valderilio F Azevedo, Kristina Callis Duffin, April W Armstrong, Alice B Gottlieb, Arthur Kavanaugh, Amit Garg, Philip S Helliwell
In advance of its 2016 annual meeting, members of the steering committee of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) convened for a strategic planning meeting. The purpose of this advance meeting was to review the work of GRAPPA since its inception in 2003, ascertain and review the current priorities of the group, and devise a strategy for proceeding. The key accomplishments of GRAPPA to date, priorities and objectives for the next 5 years, and goals and opportunities for the GRAPPA committees were discussed...
May 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28459806/identifying-systematic-heterogeneity-patterns-in-genetic-association-meta-analysis-studies
#11
Lerato E Magosi, Anuj Goel, Jemma C Hopewell, Martin Farrall
Progress in mapping loci associated with common complex diseases or quantitative inherited traits has been expedited by large-scale meta-analyses combining information across multiple studies, assembled through collaborative networks of researchers. Participating studies will usually have been independently designed and implemented in unique settings that are potential sources of phenotype, ancestry or other variability that could introduce between-study heterogeneity into a meta-analysis. Heterogeneity tests based on individual genetic variants (e...
May 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28414461/a-tetraphenylethene-naphthyridine-based-aiegen-tpen-with-dual-mechanochromic-and-chemosensing-properties
#12
Shahida Umar, Ajay Kumar Jha, Deepak Purohit, Atul Goel
Synthesis of new tetraphenylethene (TPE) conjugates via an innocuous route led to the revelation of a unique TPE-based aggregation-induced emissive fluorogen 3 (TPEN), which showed an interesting mechanochromic property when the emission was changed from blue to green upon grinding and green to blue upon fuming. The mechanochromic property of TPEN has been explored to prepare ink-free rewritable paper for security documentation. A detailed photophysical investigation of the TPE-naphthyridine scaffold led to the discovery of its high sensitivity to silver ions (Ag(+)) over other metal ions with a detection limit of 0...
May 5, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28411569/melamine-formaldehyde-derived-porous-carbons-for-adsorption-of-co2-capture
#13
Deepak Tiwari, Chitrakshi Goel, Haripada Bhunia, Pramod K Bajpai
In this work, we report carbon adsorbents obtained from high nitrogen content melamine-formaldehyde resin as starting material and mesoporous zeolite MCM-41 as template through nanocasting technique. To synthesize different carbon structure adsorbents with improved textural and surface properties, the material undergo carbonization followed by physical activation under CO2 atmosphere at different temperatures. Characterizations of the adsorbents using SEM, TEM, XPS, nitrogen sorption, CHN, TKN, and TPD have been carried out...
April 12, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28399412/cell-cycle-targeting-micrornas-as-therapeutic-tools-against-refractory-cancers
#14
Per Hydbring, Yinan Wang, Anne Fassl, Xiaoting Li, Veronica Matia, Tobias Otto, Yoon Jong Choi, Katharine E Sweeney, Jan M Suski, Hao Yin, Roman L Bogorad, Shom Goel, Haluk Yuzugullu, Kevin J Kauffman, Junghoon Yang, Chong Jin, Yingxiang Li, Davide Floris, Richard Swanson, Kimmie Ng, Ewa Sicinska, Lars Anders, Jean J Zhao, Kornelia Polyak, Daniel G Anderson, Cheng Li, Piotr Sicinski
Cyclins and cyclin-dependent kinases (CDKs) are hyperactivated in numerous human tumors. To identify means of interfering with cyclins/CDKs, we performed nine genome-wide screens for human microRNAs (miRNAs) directly regulating cell-cycle proteins. We uncovered a distinct class of miRNAs that target nearly all cyclins/CDKs, which are very effective in inhibiting cancer cell proliferation. By profiling the response of over 120 human cancer cell lines, we derived an expression-based algorithm that can predict the response of tumors to cell-cycle-targeting miRNAs...
April 10, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28394424/intrauterine-transfusions-for-severe-fetal-anemia-and-hydrops-due-to-de-novo-%C3%AE%C2%B5%C3%AE-%C3%AE-%C3%AE-thalassemia
#15
Ruchika Goel, Justin Snow, Shai M Pri-Paz, Melissa Cushing, Ljiljana V Vasovic
No abstract text is available yet for this article.
April 2017: Transfusion
https://www.readbyqxmd.com/read/28376547/changing-management-of-the-patent-ductus-arteriosus-effect-on-neonatal-outcomes-and-resource-utilization
#16
Valerie Y Chock, Veena V Goel, Jonathan P Palma, Thomas M Luh, Nichole A Wang, Shabnam Gaskari, Rajesh Punn, Norman H Silverman, William E Benitz
Objective This historical cohort study investigated how a shift toward a more conservative approach of awaiting spontaneous closure of the patent ductus arteriosus (PDA) in preterm infants has affected neonatal outcomes and resource utilization. Methods We retrospectively studied very low birth weight infants diagnosed with a PDA by echocardiogram (ECHO) in 2006-2008 (era 1), when medical or surgical PDA management was emphasized, to those born in 2010-2012 (era 2) when conservative PDA management was encouraged...
April 4, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28374414/systemic-inflammatory-response-syndrome-in-acute-on-chronic-liver-failure-relevance-of-golden-window-a-prospective-study
#17
A Choudhury, M Kumar, B C Sharma, R Maiwall, V Pamecha, R Moreau, Y K Chawla, A Duseja, M Mahtab, S Rahman, S S Hamid, A S Butt, W Jafri, S S Tan, H Devarbhavi, D Amarapurkar, Q Ning, C E Eapen, Ashish Goel, D J Kim, H Ghazinian, G Shiha, G H Lee, Z Abbas, D A Payawal, A K Dokmeci, M F Yuen, L A Lesmana, Ajit Sood, A Chan, G K Lau, J I Dong Jia, Z Duan, Yu Chen, O Yokosuka, P Jain, A S Bhadoria, G Kumar, S K Sarin
BACKGROUND: SIRS is an early marker of sepsis and ongoing inflammationand has been reported in large proportion of ACLF patients. Whether sepsis is the cause or the result of liver failure is unclear and is vital to know. To address this, we investigated the course and outcome of ACLF patients without SIRS/sepsis. METHODS: Consecutive ACLF patients were monitored for the development of SIRS/sepsis and associated complications and followed till 90 days, liver transplant or death...
April 3, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28370510/socioeconomic-burden-of-participation-in-clinical-trials-in-patients-with-myeloproliferative-neoplasms
#18
Swati Goel, Chiara Paoli, Alessandra Iurlo, Arturo Pereira, Fabio Efficace, Tiziano Barbui, Ayalew Tefferi, Alessandro M Vannucchi, Francisco Cervantes
OBJECTIVE: To determine the financial and psycho-social impact of participation in clinical trials of patients with BCR/ABL-negative myeloproliferative neoplasms (MPN). METHODS: An international, observational cross-sectional study was performed in 143 consecutive MPN patients (51% myelofibrosis, 36% polycythemia vera, 13% essential thrombocythemia), 68% from Italy, 17% from USA, and 15% from Spain. RESULTS: Thirty-five percent of patients reported having spent more money during the trial than in previous treatments and 21% having missed more workdays...
March 31, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28368388/methylation-of-wnt-target-genes-axin2-and-dkk1-as-robust-biomarkers-for-recurrence-prediction-in-stage-ii-colon-cancer
#19
R Kandimalla, J F Linnekamp, S van Hooff, A Castells, X Llor, M Andreu, R Jover, A Goel, J P Medema
Stage II colon cancer (CC) still remains a clinical challenge with patient stratification for adjuvant therapy (AT) largely relying on clinical parameters. Prognostic biomarkers are urgently needed for better stratification. Previously, we have shown that WNT target genes AXIN2, DKK1, APCDD1, ASCL2 and LGR5 are silenced by DNA methylation and could serve as prognostic markers in stage II CC patients using methylation-specific PCR. Here, we have extended our discovery cohort AMC90-AJCC-II (N=65) and methylation was analyzed by quantitative pyrosequencing...
April 3, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28364451/objective-measurements-of-energy-balance-are-associated-with-sleep-architecture-in-healthy-adults
#20
Andrea M Spaeth, David F Dinges, Namni Goel
Study Objectives: We objectively measured body composition, energy expenditure, caloric intake, and sleep in a large, diverse sample of healthy men and women and determined how energy balance and diet associated with sleep physiology. Methods: Healthy adults (n = 50; 21-50 years) participated in an in-laboratory study involving two baseline sleep nights (BL1-2, 10 hours time-in-bed/night, 2200-0800 hours). Polysomnography was recorded on BL2. Demographic information, body composition, and energy expenditure measurements were collected at study admittance and on BL1...
January 1, 2017: Sleep
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